Hub : Genes

LOC120094195

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression LOC120094195 0.45 0.2 0.0e+00 0.43 0.43 0.42 0.42 1.2e-43 2.8e-43 6.4e-43 7.4e-43
2 Brain intron excision ratio chr8_79333582_79345088 0.08 0.08 9.4e-07 0.07 0.07 0.08 0.07 2.3e-07 3.7e-07 1.1e-07 3.2e-07
3 Brain intron excision ratio chr8_79333582_79344382 0.03 0.03 5.3e-03 0.02 0.02 0.01 0.02 2.9e-03 7.9e-03 1.2e-02 6.5e-03
4 BLA gene expression LOC120094195 0.14 0.12 6.1e-07 0.12 0.12 0.11 0.11 1.0e-06 1.0e-06 1.3e-06 1.4e-06
5 pVTA mRNA stability LOC120094195 0.08 0.07 1.3e-05 0.05 0.05 0.04 0.05 6.5e-05 8.5e-05 3.3e-04 1.1e-04
6 NAcc gene expression LOC120094195 0.04 0.04 2.0e-06 0.04 0.04 0.04 0.04 9.3e-07 1.4e-06 9.2e-07 1.3e-06
7 Brain alternative TSS XR_010054429.1 0.03 0.03 4.8e-03 0.02 0.02 0.01 0.02 9.1e-03 4.9e-03 2.0e-02 8.7e-03
8 Brain alternative TSS XR_005488280.2 0.03 0.04 4.7e-03 0.02 0.02 0.02 0.02 8.0e-03 5.3e-03 7.0e-03 9.4e-03
9 pVTA intron excision ratio chr8_79333582_79344382 0.07 0.06 3.7e-05 0.05 0.06 0.05 0.05 8.2e-05 3.2e-05 5.3e-05 5.7e-05
10 LHb gene expression LOC120094195 0.73 0.2 1.2e-15 0.35 0.41 0.36 0.37 4.5e-09 9.6e-11 1.4e-09 9.7e-10
11 pVTA gene expression LOC120094195 0.41 0.17 0.0e+00 0.39 0.4 0.41 0.4 2.2e-33 1.6e-34 8.5e-35 2.2e-34
12 RMTg gene expression LOC120094195 0.17 0.16 6.7e-04 0.09 0.11 0.11 0.11 2.4e-03 9.5e-04 9.2e-04 8.4e-04
13 pVTA intron excision ratio chr8_79333582_79345088 0.07 0.07 5.0e-05 0.05 0.05 0.03 0.05 5.5e-05 7.4e-05 1.1e-03 9.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.50.91.31.1-1.11.11.11.10.8-0.90.90.90.90.90.9-0.7
Area under the delay curve0.10.10.2-0.40.2-0.2-0.2-0.2-0.30.3-0.3-0.3-0.2-0.3-0.20.1
BMI with tail7.224.926.0-5.15.1-5.0-5.1-5.1-4.94.9-4.9-4.9-5.0-5.1-4.95.0
BMI without tail3.09.09.4-2.93.0-2.9-3.0-3.0-3.03.1-3.1-3.0-3.0-3.0-3.03.1
Body weight4.921.522.0-4.74.7-4.7-4.7-4.7-4.64.6-4.6-4.6-4.6-4.6-4.64.6
Weight adjusted by age4.87.38.0-2.82.7-2.7-2.7-2.7-2.82.6-2.6-2.6-2.6-2.7-2.72.8
Bone surface0.00.10.3-0.10.1-0.2-0.2-0.2-0.40.3-0.3-0.3-0.3-0.3-0.30.5
Bone volume0.00.00.10.3-0.20.20.20.2-0.0-0.00.00.00.0-0.00.00.2
Breakpoint value in progressive ratio session0.91.11.5-1.01.0-1.0-1.1-1.1-1.21.1-1.1-1.1-1.0-1.0-1.10.9
Number of licking bursts2.13.53.71.7-1.81.81.91.91.9-1.91.91.91.91.81.9-1.9
Context. condit. distance diff. score0.91.11.31.1-1.11.11.21.21.1-1.11.11.01.01.01.1-0.9
Locomotion velocity, session 10.40.40.7-0.80.7-0.8-0.6-0.6-0.50.5-0.5-0.6-0.6-0.6-0.60.6
Locomotion distance, session 10.50.70.80.7-0.80.70.80.80.9-0.90.90.90.90.90.9-0.8
Locomotion velocity, session 20.00.00.1-0.20.2-0.2-0.1-0.1-0.00.1-0.1-0.1-0.1-0.3-0.10.0
Locomotion distance, session 20.00.00.0-0.10.0-0.2-0.0-0.00.00.0-0.0-0.0-0.0-0.0-0.00.0
Locomotion velocity, session 30.20.20.20.5-0.40.40.50.50.4-0.40.40.40.40.40.4-0.4
Locomotion distance, session 32.83.03.11.7-1.71.71.71.71.7-1.81.81.81.81.71.8-1.7
Stereotopy head waving bouts, day 31.11.31.5-1.21.2-1.2-1.2-1.2-1.11.1-1.1-1.1-1.1-1.1-1.21.1
Stereotopy head waving duration, day 31.31.61.7-1.31.3-1.3-1.3-1.3-1.31.2-1.2-1.2-1.2-1.3-1.31.1
Locomotion velocity, session 72.52.73.41.6-1.81.81.71.71.6-1.61.61.61.61.61.7-1.5
Locomotion distance, session 72.32.93.21.7-1.81.81.81.81.7-1.71.71.71.71.71.7-1.6
Stereotopy head waving bouts, day 72.52.83.2-1.61.7-1.5-1.8-1.8-1.71.7-1.7-1.7-1.7-1.7-1.71.5
Stereotopy head waving duration, day 72.22.73.1-1.51.7-1.5-1.8-1.8-1.71.7-1.7-1.7-1.6-1.6-1.71.5
Locomotion velocity, session 80.00.00.1-0.1-0.10.10.10.10.2-0.20.20.20.10.00.2-0.2
Locomotion distance, session 81.11.61.81.2-1.31.21.31.31.3-1.31.31.21.21.21.3-1.2
Degree of sensitization distance0.10.10.10.2-0.30.30.30.30.2-0.20.20.20.20.20.2-0.1
Degree of sensitization stereotypy1.51.61.8-1.11.3-1.1-1.3-1.3-1.31.3-1.3-1.3-1.3-1.3-1.31.2
Conditioned locomotion0.10.20.30.3-0.30.30.40.40.5-0.40.40.40.40.40.4-0.5
Cocaine response after cond. corrected2.93.54.0-1.91.9-1.9-1.9-1.9-1.91.9-1.9-1.9-1.9-2.0-1.81.7
Cocaine response after cond. not corrected1.61.92.2-1.41.4-1.3-1.4-1.4-1.51.4-1.4-1.4-1.4-1.5-1.31.3
Cocaine response before conditioning0.91.11.51.2-1.11.21.01.00.9-1.01.01.01.01.11.0-0.9
Saline control response0.10.10.1-0.30.3-0.3-0.3-0.3-0.30.3-0.3-0.2-0.2-0.2-0.30.1
Bone: connectivity density0.91.41.71.2-1.31.31.31.31.0-1.11.11.21.21.21.2-1.0
Bone: cortical apparent density1.21.62.01.3-1.31.31.31.31.2-1.21.21.21.31.21.3-1.4
Bone: cortical area0.20.40.50.5-0.60.70.60.60.6-0.60.60.60.60.50.6-0.5
Bone: cortical porosity1.01.01.31.1-1.01.01.01.01.0-1.01.01.01.01.11.0-1.0
Bone: cortical porosity1.51.61.91.4-1.31.31.31.31.3-1.31.31.31.31.31.2-1.1
Bone: cortical thickness2.54.24.92.0-2.02.12.02.02.0-2.02.02.02.01.92.1-2.2
Bone: cortical thickness1.21.41.91.0-1.11.11.21.21.3-1.21.21.21.21.11.3-1.4
Bone: cortical tissue density1.11.51.91.2-1.21.31.31.31.1-1.21.21.21.21.11.3-1.4
Condit. Reinf. active minus inactive responses0.00.00.00.2-0.10.10.10.10.1-0.00.00.00.0-0.00.00.2
Condit. Reinf. active-inactive response ratio0.50.50.60.8-0.70.70.80.80.7-0.70.70.70.70.60.7-0.6
Condit. Reinf. active responses0.40.50.9-0.60.6-0.7-0.6-0.6-0.70.8-0.8-0.8-0.8-0.7-0.71.0
Condit. Reinf. inactive responses1.21.51.6-1.21.2-1.3-1.2-1.2-1.21.2-1.2-1.2-1.2-1.1-1.31.2
Incentive salience index mean0.00.00.00.1-0.20.00.20.20.2-0.10.10.10.10.10.10.1
Condit. Reinf. lever presses0.10.20.20.3-0.40.20.40.40.5-0.40.40.40.40.50.4-0.3
Condit. Reinf. active minus inactive responses2.63.33.9-1.71.8-1.7-1.8-1.8-1.81.8-1.8-1.9-1.9-1.9-1.82.0
Condit. Reinf. active-inactive response ratio1.11.21.5-1.11.1-1.1-1.1-1.1-1.11.1-1.1-1.1-1.1-1.2-1.11.1
Condit. Reinf. active responses1.21.62.1-1.21.3-1.2-1.3-1.3-1.21.3-1.3-1.3-1.3-1.3-1.31.4
Condit. Reinf. inactive responses0.10.10.10.3-0.30.30.20.20.3-0.30.30.30.30.40.2-0.1
Condit. Reinf. lever presses0.81.11.41.2-1.11.21.01.01.1-1.01.01.01.01.11.0-0.9
Condit. Reinf. lever reinforcers received0.71.01.4-0.91.0-0.9-1.0-1.0-1.01.0-1.0-1.0-1.0-1.0-1.01.2
Conditioned reinforcement - actives0.50.91.3-1.01.0-1.1-1.0-1.0-0.90.9-0.9-0.9-0.9-0.9-1.00.7
Conditioned reinforcement - inactives0.00.00.00.1-0.1-0.00.20.20.1-0.20.20.20.10.10.1-0.1
Conditioned locomotion0.00.00.0-0.10.0-0.10.00.00.00.0-0.0-0.0-0.00.0-0.0-0.0
Patch foraging indifference point 0 sec0.20.30.5-0.60.5-0.5-0.5-0.5-0.60.6-0.6-0.6-0.6-0.4-0.60.7
Patch foraging indifference point AUC0.00.10.10.3-0.30.40.30.30.2-0.20.20.20.20.10.3-0.1
Delay disc. indifference point, 0s delay0.10.10.20.2-0.30.30.30.30.4-0.40.40.40.40.30.4-0.3
Delay disc. indifference point, 16s delay0.00.00.0-0.2-0.0-0.00.10.10.0-0.00.00.10.10.00.1-0.2
Delay disc. indifference point, 2s delay0.00.00.1-0.20.1-0.2-0.0-0.0-0.20.2-0.2-0.2-0.2-0.2-0.20.0
Delay disc. indifference point, 24s delay0.10.10.30.2-0.30.30.40.40.3-0.30.30.40.40.40.3-0.5
Delay disc. indifference point, 4s delay0.00.00.0-0.1-0.10.10.20.2-0.20.1-0.1-0.1-0.1-0.1-0.10.0
Delay disc. indifference point, 8s delay0.10.10.2-0.50.3-0.3-0.3-0.3-0.50.4-0.4-0.4-0.3-0.4-0.30.2
Indifference point function ln k0.40.70.9-1.00.8-0.9-0.8-0.8-0.80.9-0.9-0.9-0.9-0.8-0.90.7
Indifference point function log k0.40.70.9-1.00.8-0.9-0.8-0.8-0.80.9-0.9-0.9-0.9-0.8-0.90.7
Patch foraging total patch changes 0 sec0.20.40.6-0.60.5-0.5-0.6-0.6-0.70.6-0.6-0.6-0.6-0.4-0.70.8
Patch foraging total patch changes 12 sec0.00.00.10.2-0.20.30.20.20.0-0.10.10.10.10.10.1-0.0
Patch foraging total patch changes 18 sec0.10.10.2-0.10.3-0.3-0.3-0.3-0.30.3-0.3-0.3-0.4-0.3-0.30.5
Patch foraging total patch changes 24 sec0.00.00.10.2-0.10.10.10.1-0.10.0-0.0-0.0-0.00.1-0.00.3
Patch foraging total patch changes 6 sec0.40.51.2-0.50.5-0.5-0.6-0.6-0.90.8-0.8-0.8-0.8-0.6-0.81.1
Patch foraging time to switch 0 sec0.71.41.71.3-1.21.21.21.21.2-1.21.21.21.21.21.1-1.1
Patch foraging water rate 0 sec1.63.43.8-1.81.8-1.8-1.9-1.9-2.01.9-1.9-1.9-1.8-1.9-1.81.9
Patch foraging water rate 12 sec2.34.85.5-2.32.3-2.3-2.3-2.3-2.12.2-2.2-2.2-2.2-2.1-2.12.0
Patch foraging water rate 18 sec0.30.50.5-0.70.6-0.6-0.7-0.7-0.70.7-0.7-0.7-0.7-0.6-0.70.5
Patch foraging water rate 24 sec0.20.30.4-0.60.5-0.6-0.6-0.6-0.40.5-0.5-0.5-0.5-0.5-0.50.5
Patch foraging water rate 6 sec1.31.92.2-1.51.4-1.5-1.4-1.4-1.41.4-1.4-1.4-1.4-1.4-1.31.3
Seeking ratio, delayed vs. immediate footshock0.50.60.8-0.80.7-0.8-0.7-0.7-0.90.8-0.8-0.8-0.8-0.8-0.70.6
Distance traveled before self-admin0.30.40.6-0.80.7-0.7-0.7-0.7-0.60.6-0.6-0.6-0.6-0.6-0.60.6
Distance traveled after self-admin1.41.81.8-1.31.4-1.3-1.4-1.4-1.31.3-1.3-1.3-1.3-1.3-1.31.3
Extensor digitorum longus weight8.432.933.7-5.85.8-5.7-5.7-5.7-5.75.7-5.7-5.7-5.8-5.8-5.85.8
Bone: elastic displacement0.50.50.7-0.80.7-0.8-0.7-0.7-0.80.8-0.8-0.7-0.7-0.8-0.70.5
Bone: elastic work0.00.00.00.1-0.10.10.10.10.1-0.00.00.00.0-0.10.1-0.0
Bone: endosteal estimation2.14.55.8-2.22.1-2.1-2.0-2.0-2.12.1-2.1-2.1-2.1-2.2-2.12.4
Bone: endosteal perimeter2.86.06.9-2.52.5-2.4-2.4-2.4-2.42.4-2.4-2.4-2.5-2.5-2.42.6
Epididymis fat weight0.00.00.1-0.20.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.2-0.2-0.10.1
Delta time in closed arm before/after self-admin1.71.61.91.2-1.21.21.21.21.1-1.31.31.31.31.41.3-1.4
Delta time in open arm before/after self-admin0.30.30.40.5-0.40.50.40.40.6-0.50.50.50.50.50.5-0.5
Diff in mean of infusions in LGA sessions1.41.72.3-1.21.3-1.3-1.3-1.3-1.51.4-1.4-1.3-1.3-1.3-1.31.2
Delay discount exponential model param0.10.20.30.6-0.30.40.30.30.5-0.50.50.40.40.50.4-0.2
Extinction: sum of active levers before priming0.50.51.0-0.70.7-0.7-0.7-0.7-1.00.8-0.8-0.8-0.7-0.6-0.70.8
Active lever presses in extinction session 60.70.71.0-0.90.9-1.0-1.0-1.0-0.80.8-0.8-0.8-0.8-0.8-0.90.6
Bone: final force0.00.00.1-0.10.1-0.2-0.1-0.1-0.10.1-0.1-0.1-0.1-0.2-0.10.3
Bone: final moment0.10.10.10.4-0.30.30.30.30.3-0.30.30.30.30.30.3-0.1
Food consumed during 24 hour testing period1.11.51.7-1.21.2-1.3-1.1-1.1-1.21.2-1.2-1.3-1.3-1.3-1.31.2
Glucose0.61.01.1-1.11.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.0-1.0-1.00.8
Heart weight1.82.83.3-1.61.7-1.6-1.6-1.6-1.71.7-1.7-1.7-1.7-1.8-1.71.6
Delay discount hyperbolic model param0.10.10.20.4-0.20.20.20.20.4-0.30.30.30.30.30.3-0.1
Intermittent access intake day 1-15 change0.20.30.40.6-0.60.50.60.60.6-0.60.60.60.60.60.6-0.3
Intermittent access intake escalation0.10.30.30.5-0.60.50.50.50.6-0.60.50.50.50.50.5-0.3
Intermittent access intake escalation 20.10.10.1-0.30.3-0.4-0.3-0.3-0.30.3-0.3-0.3-0.3-0.3-0.30.3
Intermitt. access day 1 inactive lever presses1.03.63.81.8-1.91.81.91.91.9-1.91.91.91.91.91.9-1.8
Intermitt. access day 15 inactive lever presses0.20.50.6-0.70.7-0.7-0.7-0.7-0.70.7-0.7-0.7-0.7-0.7-0.80.7
Intermitt. access escalation Index0.30.50.6-0.50.6-0.6-0.7-0.7-0.70.7-0.7-0.7-0.7-0.7-0.70.8
Intermittent access day 1 total infusions0.50.80.90.9-0.90.90.90.90.9-0.90.90.90.90.90.9-0.9
Intermittent access day 15 total infusions0.81.21.41.1-1.21.11.11.11.1-1.11.11.11.11.21.1-1.0
Intermittent access terminal intake (last 3 days)0.20.30.30.5-0.60.50.50.50.5-0.50.50.50.50.60.5-0.5
Intermittent access total infusions0.10.10.20.4-0.40.30.40.40.4-0.40.40.40.40.40.3-0.3
Intermittent access day 1 locomotion1.82.32.61.5-1.51.51.61.61.5-1.51.51.51.51.61.5-1.4
Intermittent access day 15 total locomotion0.81.41.61.1-1.21.11.21.21.3-1.21.21.21.21.31.2-1.2
Intermittent access total locomotion0.10.10.1-0.30.2-0.3-0.2-0.2-0.20.3-0.3-0.3-0.3-0.2-0.30.3
Intermittent access standard deviation0.10.10.30.2-0.40.20.40.40.4-0.40.40.40.40.40.4-0.5
Left kidney weight2.19.910.5-3.23.2-3.2-3.2-3.2-3.13.2-3.2-3.2-3.2-3.1-3.23.0
Right kidney weight2.812.913.4-3.63.6-3.7-3.6-3.6-3.63.6-3.6-3.6-3.6-3.6-3.63.4
Cocaine induced anxiety0.00.00.10.2-0.20.20.20.20.1-0.10.10.10.10.20.1-0.3
Post-drug Anxiety2.32.42.61.6-1.61.61.61.61.5-1.51.51.51.51.51.5-1.5
Baseline Anxiety1.21.41.51.2-1.21.21.11.11.2-1.21.21.21.21.11.2-1.1
Tail length0.00.00.10.0-0.00.00.00.0-0.30.2-0.2-0.2-0.1-0.1-0.20.0
Length with tail0.52.32.6-1.51.5-1.5-1.5-1.5-1.61.6-1.6-1.5-1.5-1.4-1.61.4
Length without tail3.310.811.3-3.33.3-3.4-3.3-3.3-3.23.2-3.2-3.3-3.3-3.3-3.33.2
Times rat made contact with spout0.10.20.30.3-0.40.30.50.50.4-0.40.40.40.40.30.4-0.5
Lifetime Intake0.10.20.20.4-0.40.40.50.50.4-0.40.40.40.40.40.4-0.3
Liver weight, left3.35.45.8-2.32.3-2.2-2.3-2.3-2.42.4-2.4-2.3-2.3-2.3-2.32.4
Liver weight, right0.50.81.1-1.01.0-1.0-0.9-0.9-0.80.9-0.9-0.9-0.9-1.0-0.80.9
Locomotor activity7.211.211.9-3.43.4-3.4-3.4-3.4-3.33.3-3.3-3.3-3.4-3.3-3.43.2
Locomotor testing distance4.48.08.4-2.92.9-2.9-2.9-2.9-2.82.8-2.8-2.8-2.8-2.7-2.82.7
Locomotor testing rearing2.24.44.9-2.02.0-2.1-2.1-2.1-2.12.1-2.1-2.1-2.1-2.0-2.12.2
Locomotion in novel chamber0.10.10.20.4-0.40.30.40.40.2-0.30.30.30.40.50.4-0.4
Locomotion in novel chamber post-restriction0.40.70.90.9-0.90.91.01.00.7-0.80.80.80.80.70.9-0.6
Fecal boli incidents, locomotor time 10.00.00.1-0.0-0.00.00.10.1-0.10.0-0.0-0.00.0-0.00.1-0.3
Change in fecal boli incidents, locomotor task0.00.00.00.1-0.10.10.00.00.2-0.10.10.10.10.20.2-0.1
Time >=10cm from walls, locomotor time 10.20.20.3-0.50.5-0.5-0.6-0.6-0.50.4-0.4-0.4-0.4-0.5-0.30.4
Bouts of movement, locomotor time 10.10.10.3-0.50.4-0.4-0.4-0.4-0.20.1-0.1-0.1-0.1-0.1-0.10.2
Total resting periods, locomotor time 10.10.10.2-0.50.4-0.4-0.4-0.4-0.20.1-0.1-0.2-0.2-0.2-0.20.4
Rest time, locomotor task time 10.00.00.0-0.10.0-0.0-0.0-0.0-0.0-0.10.10.10.10.00.10.1
Distance moved, locomotor task time 10.10.10.20.4-0.40.30.40.40.4-0.30.30.30.30.40.3-0.3
Vertical activity count, locomotor time 10.00.10.20.4-0.30.30.30.30.4-0.30.30.30.30.30.2-0.4
Time >=10cm from walls, locomotor time 20.00.00.10.3-0.20.20.10.10.2-0.20.20.20.20.10.3-0.1
Bouts of movement, locomotor time 21.72.64.2-1.81.7-1.7-1.7-1.7-1.41.4-1.4-1.5-1.5-1.6-1.52.0
Total resting periods, locomotor time 21.72.94.3-1.91.8-1.8-1.8-1.8-1.51.5-1.5-1.6-1.6-1.6-1.62.1
Rest time, locomotor task time 20.20.20.50.2-0.30.30.30.30.5-0.50.50.50.50.50.5-0.7
Distance moved, locomotor task time 20.10.10.20.4-0.30.30.40.40.4-0.30.30.30.20.20.2-0.0
Vertical activity count, locomotor time 20.20.20.40.6-0.50.50.50.50.5-0.50.50.50.40.40.4-0.2
Light reinforcement 11.84.54.9-2.12.1-2.1-2.1-2.1-2.22.1-2.1-2.1-2.1-2.2-2.12.0
Light reinforcement 20.30.40.50.6-0.70.70.60.60.5-0.60.60.60.70.70.7-0.6
Bone: marrow area2.04.45.7-2.12.1-2.1-2.0-2.0-2.02.1-2.1-2.1-2.1-2.1-2.12.4
Bone: maximum diameter1.42.63.1-1.81.6-1.6-1.5-1.5-1.51.6-1.6-1.6-1.6-1.7-1.61.7
Bone: maximum force0.00.10.1-0.20.3-0.2-0.2-0.2-0.20.2-0.2-0.2-0.2-0.3-0.20.3
Bone: maximum moment0.00.00.10.2-0.10.10.10.10.2-0.20.20.10.10.10.1-0.1
Mean time between licks in bursts0.20.40.50.5-0.60.60.60.60.7-0.70.70.70.60.60.6-0.7
Mean num. licks in bursts1.32.12.3-1.41.4-1.5-1.4-1.4-1.51.5-1.5-1.5-1.5-1.5-1.41.4
Cd content in liver1.11.21.31.1-1.11.11.11.11.1-1.11.11.11.11.11.1-1.0
Co content in liver1.31.51.61.2-1.21.21.31.31.2-1.21.21.21.21.11.3-1.3
Cu content in liver0.10.10.20.2-0.30.30.30.30.5-0.40.40.40.40.40.3-0.4
Fe content in liver0.20.20.3-0.40.5-0.5-0.4-0.4-0.40.4-0.4-0.4-0.5-0.5-0.40.6
K content in liver1.51.41.5-1.21.2-1.1-1.2-1.2-1.21.2-1.2-1.2-1.2-1.2-1.20.9
Mg content in liver1.51.51.7-1.31.3-1.2-1.2-1.2-1.21.2-1.2-1.2-1.2-1.2-1.21.1
Mn content in liver0.00.10.20.1-0.20.20.20.20.2-0.20.20.20.20.20.3-0.5
Na content in liver6.46.97.5-2.62.6-2.5-2.5-2.5-2.72.7-2.7-2.7-2.7-2.7-2.62.7
Rb content in liver0.60.70.9-0.90.9-0.9-0.9-0.9-0.80.8-0.8-0.8-0.8-0.9-0.90.8
Se content in liver0.00.00.10.2-0.10.20.20.20.0-0.10.10.10.10.00.10.0
Sr content in liver0.10.00.10.3-0.20.30.30.30.2-0.20.20.20.20.10.2-0.1
Zn content in liver0.00.00.0-0.20.1-0.1-0.1-0.10.00.0-0.0-0.1-0.1-0.0-0.10.1
Bone: minimum diameter0.00.10.20.4-0.30.40.20.20.1-0.20.20.20.20.20.2-0.0
Time in familiar zone, hab. session 10.10.10.30.5-0.30.50.30.30.3-0.20.20.20.30.30.2-0.2
Time in novel zone, hab. session 10.00.00.0-0.1-0.0-0.10.10.10.1-0.20.20.10.10.00.2-0.2
Total zone transitions, hab. session 10.91.31.41.1-1.11.01.21.21.2-1.11.11.11.11.11.2-1.1
Total locomotion distance, hab. session 10.10.20.30.3-0.40.30.50.50.4-0.50.50.40.40.40.5-0.2
Locomotion velocity, hab. session 10.00.00.0-0.0-0.1-0.00.20.20.1-0.10.10.10.10.10.10.1
Time in familiar zone, hab. session 20.20.20.30.5-0.30.50.30.30.4-0.40.40.40.40.40.4-0.5
Time in novel zone, hab. session 20.00.00.0-0.20.0-0.20.00.0-0.10.1-0.1-0.1-0.1-0.0-0.00.1
Total zone transitions, hab. session 20.00.00.1-0.20.2-0.3-0.1-0.1-0.00.1-0.1-0.1-0.1-0.1-0.10.1
Total locomotion distance, hab. session 20.40.60.8-0.90.8-0.9-0.7-0.7-0.70.7-0.7-0.7-0.7-0.8-0.70.8
Locomotion velocity, hab. session 20.10.20.3-0.60.5-0.6-0.4-0.4-0.40.4-0.4-0.4-0.4-0.4-0.40.5
Novel to familiar place preference ratio1.61.72.1-1.11.2-1.1-1.3-1.3-1.41.4-1.4-1.4-1.4-1.3-1.41.5
Novelty place preference1.61.72.1-1.11.2-1.1-1.3-1.3-1.31.4-1.4-1.3-1.3-1.3-1.41.4
Time in novel zone, NPP test1.92.02.5-1.21.3-1.2-1.4-1.4-1.51.5-1.5-1.5-1.5-1.4-1.51.6
Total zone transitions, NPP test0.10.20.3-0.50.4-0.5-0.4-0.4-0.30.4-0.4-0.4-0.4-0.3-0.40.4
Total locomotion distance, NPP test0.60.81.0-1.00.8-1.0-0.8-0.8-0.80.8-0.8-0.9-0.9-0.9-0.81.0
Locomotion velocity, NPP test0.20.30.5-0.70.5-0.7-0.5-0.5-0.50.5-0.5-0.5-0.5-0.5-0.50.7
Intraocular pressure0.00.00.2-0.0-0.10.00.10.1-0.10.0-0.0-0.0-0.0-0.20.00.4
Delta distance traveled before/after self-admin0.60.60.7-0.70.7-0.7-0.8-0.8-0.70.8-0.8-0.8-0.8-0.8-0.80.8
Delta ambulatory time before/after self-admin0.10.20.2-0.30.4-0.4-0.4-0.4-0.20.4-0.4-0.5-0.5-0.4-0.50.4
Parametrial fat weight1.63.84.61.8-1.91.92.02.02.0-2.02.02.02.01.82.1-2.1
Pavlov. Cond. lever latency0.10.10.20.3-0.30.40.30.30.3-0.30.30.30.30.30.3-0.4
Pavlov. Cond. magazine entry latency0.91.21.31.0-1.11.11.11.11.1-1.11.11.11.11.11.1-1.0
Pavlov. Cond. change in total contacts0.00.00.1-0.20.2-0.2-0.1-0.1-0.10.1-0.1-0.1-0.1-0.2-0.10.2
Pavlov. Cond. index score0.60.80.90.8-0.90.80.90.90.9-0.90.90.90.90.90.9-0.9
Pavlov. Cond. latency score0.30.30.40.6-0.60.50.60.60.6-0.60.60.60.60.60.6-0.5
Pavlov. Cond. lever contacts0.00.00.00.2-0.10.10.20.20.2-0.10.10.10.10.10.2-0.1
Pavlov. Cond. magazine entry number1.21.51.6-1.21.2-1.2-1.2-1.2-1.21.2-1.3-1.2-1.2-1.2-1.21.2
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.00.2-0.2-0.3-0.3-0.30.3-0.3-0.3-0.3-0.2-0.30.2
Pavlov. Cond. lever-magazine prob. diff.0.40.50.50.6-0.70.60.70.70.7-0.70.70.70.70.70.7-0.7
Pavlov. Cond. response bias0.40.60.60.7-0.70.70.80.80.7-0.80.80.80.80.80.8-0.7
Pavlov. Cond. lever latency0.40.60.8-0.90.8-0.9-0.7-0.7-0.80.8-0.8-0.8-0.8-0.8-0.70.6
Pavlov. Cond. magazine entry latency3.84.65.12.1-2.12.22.12.12.2-2.12.12.12.12.12.1-2.3
Pavlov. Cond. change in total contacts0.40.70.80.9-0.80.90.80.80.9-0.80.80.80.80.80.8-0.8
Pavlov. Cond. index score1.31.72.01.4-1.31.41.21.21.4-1.31.31.31.31.31.2-1.2
Pavlov. Cond. latency score0.81.01.21.1-1.01.11.01.01.1-1.01.01.01.01.01.0-1.0
Pavlov. Cond. lever contacts0.40.60.70.8-0.80.80.70.70.8-0.80.80.70.70.80.7-0.5
Pavlov. Cond. magazine entry number4.35.35.8-2.42.3-2.4-2.3-2.3-2.42.3-2.3-2.3-2.3-2.3-2.32.3
Pavlov. Cond. intertrial magazine entries0.91.31.7-1.11.1-1.0-1.1-1.1-1.31.2-1.2-1.2-1.1-1.1-1.11.2
Pavlov. Cond. lever-magazine prob. diff.1.52.02.31.5-1.41.51.31.31.5-1.41.41.41.41.41.4-1.3
Pavlov. Cond. response bias1.82.42.71.7-1.61.61.51.51.6-1.51.51.51.51.61.5-1.4
Time in closed arm before self-admin0.00.10.2-0.30.3-0.4-0.3-0.30.10.1-0.1-0.1-0.2-0.2-0.2-0.1
Time in closed arm after self-admin0.40.41.20.6-0.50.50.50.50.7-0.60.60.70.70.70.7-1.1
Time in open arm before self-admin0.50.61.1-0.60.6-0.5-0.7-0.7-1.00.8-0.8-0.8-0.8-0.7-0.81.0
Time in open arm after self-admin0.20.20.5-0.40.4-0.4-0.5-0.5-0.50.5-0.5-0.5-0.5-0.5-0.50.7
Bone: periosteal estimation0.71.52.0-1.31.2-1.1-1.2-1.2-1.21.2-1.2-1.2-1.2-1.3-1.21.4
Bone: periosteal perimeter1.32.22.6-1.51.5-1.4-1.4-1.4-1.51.5-1.5-1.5-1.5-1.6-1.51.6
Bone: post-yield work0.10.10.1-0.20.4-0.3-0.4-0.4-0.10.2-0.2-0.2-0.3-0.2-0.30.2
Progressive ratio test 1 active lever presses0.10.10.20.3-0.30.30.40.40.3-0.30.30.30.30.30.3-0.2
Progressive ratio test 1 breakpoint0.10.10.20.4-0.40.30.50.50.4-0.40.40.40.40.40.4-0.3
Progressive ratio test 1 inactive lever presses2.73.94.22.0-2.02.02.12.12.0-2.02.02.02.01.92.0-1.7
Progressive ratio test 2 active lever presses0.30.40.6-0.50.5-0.6-0.5-0.5-0.60.6-0.6-0.6-0.6-0.6-0.60.7
Progressive ratio test 2 breakpoint0.30.30.5-0.50.5-0.6-0.5-0.5-0.60.6-0.6-0.6-0.6-0.6-0.60.7
Progressive ratio test 2 inactive lever presses0.00.10.10.1-0.30.20.30.30.2-0.20.20.20.20.20.20.0
Incentive Sensitization - Responses0.40.60.7-0.60.7-0.7-0.8-0.8-0.80.8-0.8-0.8-0.8-0.8-0.80.8
Incentive Sensitization - Breakpoint0.30.40.5-0.50.6-0.6-0.7-0.7-0.70.7-0.7-0.7-0.7-0.7-0.70.7
Sum of active levers in priming session hrs 5-60.20.20.3-0.30.4-0.4-0.5-0.5-0.50.5-0.5-0.5-0.5-0.5-0.50.5
Progressive ratio0.20.30.70.3-0.50.40.50.50.8-0.80.80.70.60.60.5-0.4
Food seeking constrained by brief footshock0.20.20.3-0.50.5-0.5-0.5-0.5-0.50.4-0.4-0.4-0.3-0.4-0.50.3
Seeking ratio, punishment vs. effort2.13.04.0-1.61.7-1.6-1.7-1.7-2.01.9-1.9-1.8-1.8-1.8-1.71.5
Retroperitoneal fat weight0.20.60.90.6-0.70.70.80.80.8-0.80.80.80.80.60.9-0.9
Reaction time number correct1.22.42.6-1.61.5-1.6-1.6-1.6-1.51.5-1.5-1.5-1.5-1.5-1.51.5
Reaction time mean minus median0.00.10.20.1-0.20.30.20.20.4-0.30.30.30.30.40.2-0.1
Reaction time mean minus median AUC0.30.91.20.8-0.91.00.80.81.1-1.01.01.00.91.00.9-0.8
Reaction time num false alarms1.01.31.61.1-1.11.11.21.21.1-1.21.21.21.21.11.2-1.3
Reaction time num false alarms AUC0.50.71.20.8-0.80.80.80.80.9-0.90.90.90.80.80.8-1.1
Reaction time trials correct on left1.22.42.6-1.61.5-1.6-1.6-1.6-1.51.5-1.5-1.5-1.5-1.5-1.51.5
Reaction time trials on left1.32.52.8-1.71.6-1.6-1.6-1.6-1.51.6-1.6-1.6-1.6-1.6-1.51.6
Reaction time mean2.54.04.52.0-2.02.12.02.02.1-2.02.02.02.02.02.0-1.8
Reaction time mean AUC1.82.83.21.6-1.71.81.71.71.8-1.71.71.71.61.71.6-1.4
Median of all reaction times4.96.97.42.6-2.72.72.72.72.7-2.62.62.62.62.62.6-2.4
Reaction time omissions0.10.20.3-0.50.4-0.4-0.4-0.4-0.40.4-0.4-0.4-0.4-0.3-0.40.4
Reaction time false alarm rate2.02.83.41.6-1.61.61.71.71.7-1.71.71.71.71.61.6-1.8
Reaction time premature initiation rate1.42.02.5-1.61.4-1.6-1.3-1.3-1.51.4-1.4-1.4-1.4-1.3-1.41.2
Reaction time premature initiations2.03.54.3-2.11.9-2.1-1.8-1.8-1.91.9-1.9-1.8-1.8-1.8-1.81.7
Std. dev. reaction times0.71.31.71.0-1.11.21.11.11.3-1.21.21.21.11.21.1-1.0
Reaction time trials completed1.32.52.8-1.71.6-1.6-1.6-1.6-1.51.6-1.6-1.6-1.6-1.6-1.51.6
Reaction time trials AUC1.12.12.3-1.51.5-1.5-1.5-1.5-1.41.4-1.4-1.4-1.4-1.4-1.41.5
Run reversals in cocaine runway, females0.10.10.30.2-0.20.20.20.2-0.1-0.10.10.20.20.20.3-0.5
Run reversals in cocaine runway, males0.00.00.0-0.10.1-0.2-0.2-0.20.1-0.00.00.0-0.0-0.10.0-0.0
Latency to leave start box in cocaine runway3.54.04.2-2.02.0-2.0-2.0-2.0-2.02.1-2.1-2.0-2.0-1.9-2.01.9
Latency to leave start box in cocaine runway, F1.21.41.6-1.21.2-1.2-1.2-1.2-1.21.2-1.2-1.2-1.2-1.1-1.11.3
Latency to leave start box in cocaine runway, M6.86.37.0-2.72.6-2.6-2.6-2.6-2.52.5-2.5-2.5-2.5-2.4-2.72.0
Std. dev. time between licks in bursts0.20.20.3-0.40.4-0.3-0.5-0.5-0.50.5-0.5-0.5-0.5-0.4-0.50.6
Total sessions with >9 infusions0.40.40.50.7-0.60.60.70.70.7-0.70.70.70.70.60.7-0.5
Short access day 1 total inactive lever presses0.60.81.01.0-0.90.91.01.00.9-0.90.90.90.90.80.9-0.6
Short access day 10 total inactive lever presses0.30.80.90.9-0.91.00.80.81.0-0.90.90.90.90.90.9-0.8
Short access day 1 total infusions0.10.10.10.3-0.30.30.40.40.3-0.30.30.30.30.30.3-0.2
Short access day 10 total infusions1.31.71.81.3-1.31.31.41.41.3-1.31.31.31.31.31.3-1.1
Short access total infusions0.60.80.90.9-0.90.80.90.90.8-0.90.90.90.90.90.9-0.8
Short access day 1 locomotion0.10.10.20.4-0.40.40.50.50.3-0.30.30.30.30.30.3-0.1
Short access day 10 total locomotion0.30.60.70.7-0.80.80.80.80.8-0.80.80.80.80.90.8-0.8
Short access total locomotion0.50.60.70.7-0.70.70.80.80.8-0.80.80.80.80.80.8-0.8
One hour access (0.3 mA shock)0.91.11.4-1.11.1-1.2-1.1-1.1-1.01.0-1.0-1.0-1.0-1.0-1.00.8
Compulsive drug intake0.81.01.2-0.91.1-1.0-1.0-1.0-1.01.0-1.0-1.0-1.0-1.0-1.00.7
One hour access (shock baseline)0.00.10.10.2-0.30.20.20.20.2-0.20.20.20.20.30.2-0.2
Social response proportion0.00.00.10.2-0.10.10.10.10.1-0.10.10.10.10.20.1-0.3
Social responses0.00.00.0-0.10.1-0.2-0.2-0.2-0.10.2-0.2-0.1-0.10.0-0.1-0.0
Social time0.10.10.1-0.40.3-0.4-0.3-0.3-0.40.4-0.4-0.3-0.3-0.2-0.40.1
Soleus weight16.849.552.2-7.07.0-7.0-7.0-7.0-7.07.0-7.1-7.1-7.1-7.0-7.17.2
Bone: stiffness0.50.81.0-0.70.9-0.9-0.9-0.9-0.90.9-0.9-0.9-0.9-0.9-0.91.0
Tibialis anterior weight13.445.446.4-6.76.8-6.7-6.7-6.7-6.76.7-6.7-6.7-6.8-6.8-6.76.8
Time to tail flick, vehicle, before self-admin0.40.40.70.5-0.50.40.50.50.7-0.70.70.70.60.60.6-0.8
Time to tail flick, vehicle, after self-admin0.20.30.50.3-0.40.30.40.40.7-0.60.60.60.50.60.5-0.6
Time to tail flick, test, before self-admin2.62.72.81.7-1.61.61.61.61.6-1.71.71.71.71.61.6-1.6
Time to tail flick, test, after self-admin1.11.21.51.1-1.01.00.90.91.2-1.11.11.11.11.11.0-1.2
Delta time to tail flick, vehicle, before/after SA0.20.20.30.4-0.40.40.40.40.6-0.50.50.50.40.50.4-0.3
Delta time to tail flick, test, before/after SA0.40.50.7-0.80.7-0.8-0.8-0.8-0.50.6-0.6-0.6-0.7-0.6-0.60.5
Tibia length0.00.00.10.3-0.20.20.30.30.2-0.20.20.20.20.20.2-0.2
Ambulatory time before self-admin0.00.00.1-0.30.2-0.2-0.2-0.2-0.20.1-0.1-0.1-0.1-0.2-0.10.2
Ambulatory time after self-admin0.50.60.6-0.80.8-0.8-0.8-0.8-0.60.7-0.7-0.7-0.8-0.7-0.70.8
Bone: tissue strength1.41.51.71.3-1.21.21.21.21.2-1.21.21.21.21.21.2-1.3
Total heroin consumption2.22.62.8-1.51.6-1.5-1.7-1.7-1.61.6-1.6-1.6-1.6-1.6-1.61.5
Bone: trabecular number1.52.53.01.7-1.71.71.71.71.5-1.51.51.61.61.51.6-1.4
Bone: trabecular spacing0.00.10.1-0.30.3-0.3-0.3-0.3-0.10.2-0.2-0.2-0.2-0.2-0.30.2
Bone: trabecular thickness0.70.91.10.9-1.01.01.11.10.8-0.90.90.90.90.81.0-0.9
Bone: trabecular tissue density3.55.25.7-2.42.3-2.3-2.3-2.3-2.22.3-2.3-2.3-2.3-2.3-2.32.0
Water consumed over 24 hours0.10.20.30.4-0.40.40.50.50.4-0.40.40.40.40.40.5-0.5
Number of responses in last shaping day0.10.20.4-0.50.3-0.4-0.3-0.3-0.30.3-0.3-0.4-0.4-0.3-0.40.7