Hub : Genes

Aldh3b3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Aldh3b3 0.57 0.18 1.3e-08 0.2 0.28 0.32 0.31 1.4e-05 2.0e-07 1.9e-08 3.4e-08
2 OFC isoform ratio XM_039101315.2 0.2 0.14 6.3e-03 0.05 0.09 0.12 0.09 2.5e-02 4.6e-03 8.3e-04 3.4e-03
3 OFC isoform ratio XM_039101314.2 0.2 0.14 7.7e-03 0.04 0.08 0.13 0.09 3.2e-02 6.0e-03 6.6e-04 4.5e-03
4 NAcc isoform ratio XM_039101314.2 0.05 0.04 2.2e-05 0.04 0.04 0.04 0.04 1.5e-06 2.3e-06 1.6e-06 2.0e-06
5 PL isoform ratio XM_039101315.2 0.09 0.06 2.9e-07 0.06 0.07 0.06 0.07 5.4e-07 8.3e-08 1.8e-07 8.6e-08
6 PL isoform ratio XM_039101314.2 0.09 0.06 3.7e-07 0.06 0.07 0.06 0.07 8.1e-07 1.0e-07 2.5e-07 1.1e-07
7 NAcc gene expression Aldh3b3 0.07 0.05 4.3e-08 0.04 0.06 0.05 0.06 1.7e-07 4.1e-09 1.6e-08 6.1e-09
8 OFC intron excision ratio chr1_210644761_210646067 0.3 0.17 3.8e-04 0.08 0.11 0.13 0.12 6.0e-03 1.3e-03 4.8e-04 7.1e-04
9 OFC intron excision ratio chr1_210661540_210662846 0.3 0.17 4.0e-04 0.08 0.11 0.13 0.13 6.3e-03 1.4e-03 5.0e-04 6.4e-04
10 OFC intron excision ratio chr1_210627982_210629288 0.3 0.17 3.3e-04 0.08 0.12 0.14 0.13 5.0e-03 1.0e-03 4.2e-04 6.2e-04
11 PL gene expression Aldh3b3 0.48 0.16 0.0e+00 0.26 0.45 0.45 0.45 1.1e-28 6.4e-54 1.1e-53 1.3e-53
12 BLA gene expression Aldh3b3 0.4 0.16 0.0e+00 0.2 0.31 0.32 0.31 6.6e-11 1.1e-16 7.8e-18 4.3e-17
13 OFC intron excision ratio chr1_210678203_210679509 0.3 0.17 3.8e-04 0.08 0.11 0.07 0.12 6.8e-03 1.4e-03 9.4e-03 8.4e-04
14 IC gene expression Aldh3b3 0.59 0.16 0.0e+00 0.33 0.35 0.34 0.32 2.7e-14 1.2e-15 3.3e-15 6.6e-14
15 Brain intron excision ratio chr1_210624747_210625093 0.04 0.03 2.4e-03 0.01 0.02 0.02 0.01 6.4e-02 6.8e-03 9.0e-03 3.3e-02
16 Brain intron excision ratio chr1_210624747_210625152 0.04 0.03 2.7e-03 0.01 0.02 0.02 0.01 6.8e-02 8.4e-03 1.1e-02 4.0e-02
17 Brain gene expression Aldh3b3 0.31 0.15 0.0e+00 0.16 0.21 0.22 0.21 8.2e-15 3.2e-19 5.4e-20 1.5e-19
18 IC isoform ratio XM_039101314.2 0.25 0.14 6.9e-06 0.05 0.07 0.07 0.07 4.1e-03 8.6e-04 9.5e-04 8.2e-04
19 IL gene expression Aldh3b3 0.43 0.19 9.7e-06 0.11 0.18 0.2 0.21 1.4e-03 3.6e-05 1.3e-05 9.6e-06
20 pVTA gene expression Aldh3b3 0.04 0.03 2.4e-03 0.04 0.02 0.01 0.02 4.5e-04 1.2e-02 3.0e-02 4.6e-03
21 IC isoform ratio XM_039101315.2 0.26 0.15 4.8e-06 0.08 0.07 0.06 0.07 2.3e-04 7.7e-04 1.2e-03 6.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density2.34.37.41.1-0.60.50.52.1-2.1-2.12.02.02.0-2.21.8-2.2-2.42.5-2.52.2-2.2-2.72.7-2.4
Area under the delay curve0.40.51.30.3-0.50.50.00.6-0.6-0.60.60.60.6-0.70.6-0.7-0.90.9-0.90.8-0.9-1.01.1-1.0
BMI with tail3.311.514.32.8-3.33.32.13.4-3.4-3.43.43.43.4-3.53.2-3.5-3.63.6-3.63.7-3.8-3.33.4-3.6
BMI without tail1.15.76.42.5-2.42.52.02.5-2.5-2.52.52.52.5-2.52.4-2.4-2.42.4-2.42.5-2.5-2.02.0-2.1
Body weight2.812.518.14.1-4.24.33.73.8-3.8-3.73.73.73.7-3.73.8-3.6-3.43.2-3.23.4-3.1-2.42.4-2.3
Weight adjusted by age0.20.61.61.0-1.21.21.30.8-0.8-0.80.90.90.9-0.71.0-0.8-0.60.5-0.50.7-0.5-0.20.1-0.1
Bone surface4.58.811.02.4-2.12.01.83.2-3.2-3.23.13.13.1-3.32.9-3.2-3.33.3-3.33.1-3.0-3.23.1-2.8
Bone volume2.04.06.11.2-0.90.80.72.1-2.1-2.12.02.02.0-2.21.8-2.1-2.32.4-2.42.1-2.1-2.52.5-2.2
Breakpoint value in progressive ratio session1.22.22.91.6-1.71.71.71.6-1.6-1.61.61.61.6-1.51.6-1.5-1.41.3-1.31.6-1.3-1.00.8-0.9
Number of licking bursts0.00.10.2-0.20.4-0.5-0.20.3-0.3-0.30.10.10.1-0.30.2-0.2-0.30.4-0.40.1-0.0-0.40.4-0.1
Context. condit. distance diff. score0.50.61.7-1.11.2-1.3-1.3-0.80.80.8-0.8-0.8-0.80.7-0.80.80.5-0.40.4-0.50.40.1-0.10.0
Locomotion velocity, session 10.00.00.0-0.00.0-0.0-0.10.0-0.0-0.10.00.00.0-0.10.10.0-0.10.1-0.10.1-0.2-0.10.1-0.2
Locomotion distance, session 11.62.13.10.9-0.80.80.51.4-1.5-1.51.41.41.4-1.51.4-1.5-1.61.7-1.71.6-1.6-1.71.7-1.7
Locomotion velocity, session 21.51.83.21.8-1.81.81.71.5-1.5-1.41.41.41.4-1.31.5-1.3-1.11.0-1.01.2-1.0-0.60.6-0.6
Locomotion distance, session 21.31.92.11.2-1.31.31.11.5-1.5-1.51.41.41.4-1.51.4-1.4-1.41.4-1.41.5-1.4-1.31.2-1.2
Locomotion velocity, session 31.01.22.60.3-0.30.3-0.10.9-0.9-1.00.90.90.9-1.10.8-1.0-1.21.3-1.31.2-1.4-1.51.5-1.6
Locomotion distance, session 30.10.10.50.1-0.00.0-0.20.2-0.2-0.30.20.20.2-0.30.3-0.2-0.30.4-0.40.5-0.6-0.40.4-0.7
Stereotopy head waving bouts, day 30.40.51.5-0.10.1-0.1-0.40.4-0.4-0.40.50.50.5-0.50.3-0.6-0.80.9-0.90.7-0.9-1.21.2-1.2
Stereotopy head waving duration, day 30.20.20.9-0.80.7-0.8-0.9-0.40.30.3-0.2-0.2-0.20.2-0.50.1-0.00.2-0.2-0.1-0.1-0.50.6-0.4
Locomotion velocity, session 70.70.71.80.3-0.30.3-0.00.7-0.7-0.80.70.80.8-0.80.6-0.8-1.01.0-1.01.0-1.2-1.21.2-1.3
Locomotion distance, session 70.40.60.80.7-0.60.60.50.8-0.8-0.80.70.70.7-0.80.8-0.7-0.80.8-0.80.9-0.9-0.70.7-0.8
Stereotopy head waving bouts, day 70.50.51.70.00.1-0.1-0.40.5-0.5-0.50.50.60.6-0.60.2-0.7-0.81.0-1.00.7-0.9-1.31.3-1.1
Stereotopy head waving duration, day 71.62.03.01.1-0.90.90.61.4-1.4-1.41.51.51.5-1.51.1-1.5-1.61.6-1.61.4-1.4-1.71.7-1.4
Locomotion velocity, session 81.01.22.01.4-1.21.11.31.3-1.3-1.31.21.21.2-1.21.3-1.2-1.01.0-1.01.0-0.8-0.70.6-0.5
Locomotion distance, session 80.10.10.6-0.50.7-0.8-0.8-0.10.10.1-0.2-0.2-0.2-0.0-0.10.1-0.10.2-0.20.1-0.2-0.50.4-0.5
Degree of sensitization distance0.60.60.80.6-0.60.60.60.9-0.9-0.90.90.90.9-0.90.7-0.9-0.90.9-0.90.9-0.8-0.80.8-0.8
Degree of sensitization stereotypy0.60.71.20.7-0.50.40.30.8-0.8-0.90.90.90.9-0.90.6-0.9-1.01.0-1.00.8-0.8-1.11.1-0.8
Conditioned locomotion0.50.62.71.3-1.11.21.60.5-0.5-0.40.40.40.4-0.30.6-0.20.1-0.30.3-0.10.50.9-0.91.1
Cocaine response after cond. corrected0.00.00.1-0.20.2-0.2-0.4-0.20.20.2-0.2-0.2-0.20.1-0.20.10.1-0.00.0-0.0-0.0-0.10.1-0.1
Cocaine response after cond. not corrected0.00.10.2-0.20.2-0.2-0.40.1-0.1-0.10.10.10.1-0.1-0.0-0.1-0.30.3-0.30.2-0.3-0.50.5-0.4
Cocaine response before conditioning0.10.10.20.1-0.0-0.00.10.4-0.4-0.40.40.40.4-0.40.2-0.4-0.40.4-0.40.2-0.2-0.50.5-0.2
Saline control response2.12.94.72.1-2.02.02.21.9-1.9-1.91.91.91.9-1.81.8-1.8-1.61.5-1.51.3-1.0-1.01.0-0.5
Bone: connectivity density5.18.110.52.3-1.71.61.63.0-3.1-3.13.03.03.0-3.12.8-3.1-3.23.2-3.23.0-2.9-3.13.1-2.8
Bone: cortical apparent density0.10.10.40.4-0.50.50.60.2-0.1-0.10.10.10.1-0.10.30.00.1-0.20.20.00.10.4-0.50.3
Bone: cortical area0.10.20.70.6-0.50.50.90.3-0.3-0.30.20.20.2-0.20.3-0.10.0-0.10.1-0.20.40.4-0.50.8
Bone: cortical porosity0.10.10.20.2-0.40.40.20.3-0.3-0.30.30.30.3-0.30.2-0.3-0.30.3-0.30.2-0.2-0.30.3-0.1
Bone: cortical porosity0.20.30.60.6-0.70.70.60.5-0.5-0.50.60.60.6-0.50.5-0.5-0.50.4-0.40.3-0.3-0.30.3-0.1
Bone: cortical thickness1.01.77.42.2-2.12.12.71.2-1.2-1.11.01.01.0-0.91.3-0.8-0.30.0-0.00.20.30.9-1.01.3
Bone: cortical thickness0.50.72.51.4-1.01.01.60.9-0.9-0.90.90.90.9-0.80.9-0.7-0.50.3-0.30.4-0.10.1-0.20.4
Bone: cortical tissue density0.10.10.60.6-0.70.70.80.3-0.3-0.30.20.20.2-0.20.4-0.10.0-0.10.10.2-0.00.4-0.50.3
Condit. Reinf. active minus inactive responses0.40.50.90.4-0.40.40.10.6-0.7-0.70.60.60.6-0.70.6-0.6-0.80.8-0.80.8-0.9-0.80.8-1.0
Condit. Reinf. active-inactive response ratio0.10.10.50.0-0.10.1-0.10.2-0.2-0.20.30.30.3-0.30.2-0.3-0.40.4-0.40.5-0.6-0.50.5-0.7
Condit. Reinf. active responses0.00.00.20.0-0.10.1-0.10.1-0.1-0.20.10.10.1-0.20.2-0.1-0.20.2-0.20.3-0.4-0.20.2-0.4
Condit. Reinf. inactive responses0.10.20.2-0.40.4-0.3-0.3-0.40.40.4-0.4-0.4-0.40.4-0.40.40.4-0.40.4-0.40.30.4-0.40.3
Incentive salience index mean0.30.40.70.4-0.30.30.10.6-0.6-0.70.60.60.6-0.70.6-0.5-0.70.7-0.70.8-0.8-0.70.7-0.8
Condit. Reinf. lever presses0.00.00.1-0.00.2-0.2-0.20.1-0.1-0.1-0.1-0.1-0.1-0.00.10.2-0.0-0.00.0-0.00.10.1-0.10.1
Condit. Reinf. active minus inactive responses0.20.31.3-0.50.5-0.5-0.90.1-0.1-0.20.10.10.1-0.30.0-0.3-0.60.7-0.70.6-0.7-1.01.0-1.1
Condit. Reinf. active-inactive response ratio0.40.62.5-1.41.3-1.3-1.6-0.80.80.7-0.8-0.8-0.80.6-0.80.60.3-0.20.2-0.30.1-0.30.3-0.4
Condit. Reinf. active responses0.81.12.60.2-0.30.2-0.20.8-0.9-0.90.90.90.9-1.00.7-1.0-1.21.3-1.31.2-1.3-1.51.6-1.6
Condit. Reinf. inactive responses1.52.22.61.4-1.31.31.11.5-1.5-1.61.61.61.6-1.61.4-1.6-1.61.6-1.61.5-1.5-1.51.5-1.4
Condit. Reinf. lever presses1.31.92.61.0-0.80.80.71.5-1.5-1.51.41.41.4-1.51.3-1.5-1.61.6-1.61.4-1.3-1.61.6-1.3
Condit. Reinf. lever reinforcers received1.11.52.90.5-0.50.50.11.1-1.1-1.21.11.11.1-1.31.0-1.2-1.41.5-1.51.4-1.5-1.71.7-1.7
Conditioned reinforcement - actives0.31.01.5-0.70.6-0.4-0.4-1.01.11.1-1.0-1.0-1.01.1-0.91.11.2-1.21.2-1.01.11.2-1.11.1
Conditioned reinforcement - inactives0.92.45.3-2.32.3-2.2-2.1-1.71.71.6-1.6-1.6-1.61.5-1.71.51.2-1.11.1-1.00.90.6-0.60.3
Conditioned locomotion7.210.717.3-4.23.9-3.9-3.6-3.63.53.5-3.5-3.5-3.53.4-3.53.43.1-2.92.9-2.92.62.2-2.21.8
Patch foraging indifference point 0 sec0.10.20.6-0.50.1-0.0-0.6-0.50.50.5-0.4-0.4-0.40.4-0.80.40.3-0.30.3-0.50.40.1-0.10.3
Patch foraging indifference point AUC0.10.20.70.5-0.80.80.90.4-0.4-0.40.20.20.2-0.30.6-0.1-0.1-0.10.10.20.00.5-0.50.4
Delay disc. indifference point, 0s delay0.91.02.70.2-0.80.8-0.10.8-0.9-0.90.90.90.9-1.00.6-1.0-1.21.3-1.30.9-1.1-1.51.6-1.2
Delay disc. indifference point, 16s delay0.40.61.4-1.20.8-0.9-1.1-0.90.80.8-0.8-0.8-0.80.7-0.90.70.6-0.50.5-0.70.50.2-0.10.2
Delay disc. indifference point, 2s delay0.20.20.7-0.80.7-0.8-0.7-0.10.10.1-0.1-0.1-0.1-0.0-0.1-0.0-0.20.3-0.30.1-0.2-0.60.6-0.5
Delay disc. indifference point, 24s delay0.10.10.40.6-0.40.50.3-0.10.10.1-0.1-0.1-0.10.2-0.10.10.3-0.30.3-0.40.40.4-0.50.5
Delay disc. indifference point, 4s delay0.40.40.80.1-0.60.50.10.6-0.6-0.60.50.50.5-0.70.7-0.6-0.70.8-0.80.8-0.9-0.70.9-0.9
Delay disc. indifference point, 8s delay0.20.40.60.8-0.80.80.30.6-0.6-0.60.60.60.6-0.60.6-0.6-0.70.7-0.70.5-0.7-0.70.8-0.7
Indifference point function ln k1.44.36.8-2.42.6-2.5-2.4-2.32.32.3-2.2-2.2-2.22.2-2.32.11.9-1.81.8-1.91.61.2-1.01.0
Indifference point function log k1.44.36.8-2.42.6-2.5-2.4-2.32.32.3-2.2-2.2-2.22.2-2.32.11.9-1.81.8-1.91.61.2-1.01.0
Patch foraging total patch changes 0 sec0.10.20.5-0.2-0.10.2-0.2-0.50.50.5-0.5-0.5-0.50.5-0.70.40.5-0.50.5-0.60.70.4-0.50.7
Patch foraging total patch changes 12 sec1.41.94.01.7-2.02.01.71.6-1.6-1.51.41.41.4-1.51.5-1.3-1.21.1-1.11.2-1.0-0.60.6-0.4
Patch foraging total patch changes 18 sec0.10.30.60.4-0.70.70.60.6-0.6-0.60.60.60.6-0.60.6-0.6-0.60.5-0.50.5-0.4-0.40.4-0.3
Patch foraging total patch changes 24 sec0.10.30.90.9-0.91.00.90.5-0.5-0.50.40.40.4-0.40.6-0.3-0.20.1-0.10.3-0.20.3-0.20.1
Patch foraging total patch changes 6 sec1.11.83.51.3-1.81.91.11.4-1.4-1.41.41.41.4-1.41.2-1.4-1.41.3-1.31.2-1.1-1.11.2-0.9
Patch foraging time to switch 0 sec1.35.06.41.6-1.41.21.42.3-2.3-2.32.42.42.4-2.42.2-2.5-2.52.5-2.52.3-2.4-2.52.5-2.3
Patch foraging water rate 0 sec2.911.013.1-2.92.8-2.7-2.5-3.53.53.5-3.6-3.6-3.63.5-3.43.63.5-3.53.5-3.43.43.3-3.23.1
Patch foraging water rate 12 sec3.514.317.2-3.53.3-3.2-3.2-4.04.04.1-4.1-4.1-4.14.1-3.74.14.0-3.93.9-3.83.63.5-3.53.1
Patch foraging water rate 18 sec1.12.52.9-1.41.7-1.7-1.5-1.71.71.7-1.7-1.7-1.71.7-1.51.61.6-1.61.6-1.61.51.2-1.31.2
Patch foraging water rate 24 sec4.05.87.0-1.81.6-1.5-1.7-2.52.52.5-2.6-2.6-2.62.6-2.42.62.6-2.62.6-2.52.52.5-2.52.3
Patch foraging water rate 6 sec3.45.06.1-1.82.1-2.1-1.4-2.32.32.3-2.3-2.3-2.32.4-2.02.32.4-2.52.5-2.32.42.3-2.32.2
Seeking ratio, delayed vs. immediate footshock0.50.71.30.5-0.70.80.20.7-0.7-0.70.80.80.8-0.80.7-0.9-0.91.0-1.00.8-1.1-1.11.1-1.1
Distance traveled before self-admin0.20.40.70.4-0.1-0.00.10.6-0.6-0.60.60.60.6-0.60.5-0.6-0.70.8-0.80.7-0.8-0.80.8-0.9
Distance traveled after self-admin0.00.00.10.20.2-0.30.10.2-0.2-0.20.20.20.2-0.20.2-0.2-0.20.2-0.20.1-0.2-0.30.2-0.2
Extensor digitorum longus weight3.815.233.15.2-5.55.55.84.3-4.2-4.14.24.24.2-3.84.5-3.8-3.12.6-2.63.2-2.5-1.21.0-0.9
Bone: elastic displacement1.62.04.2-0.40.2-0.2-0.1-1.21.21.3-1.3-1.3-1.31.4-1.11.51.7-1.81.8-1.51.72.0-2.01.9
Bone: elastic work0.50.72.61.4-1.51.51.60.7-0.7-0.60.60.60.6-0.50.8-0.4-0.1-0.10.10.10.20.6-0.70.7
Bone: endosteal estimation0.30.73.4-1.51.4-1.4-1.8-0.70.60.6-0.6-0.6-0.60.4-0.80.40.00.2-0.2-0.1-0.2-0.70.8-0.8
Bone: endosteal perimeter0.61.57.2-2.12.0-2.0-2.7-1.01.00.9-0.9-0.9-0.90.6-1.20.60.10.2-0.2-0.1-0.3-1.01.2-1.3
Epididymis fat weight2.211.319.5-4.44.2-4.2-4.0-3.73.73.7-3.5-3.5-3.53.5-3.73.43.0-2.82.8-3.12.71.9-1.61.8
Delta time in closed arm before/after self-admin0.50.51.71.0-1.31.31.10.8-0.7-0.70.70.70.6-0.60.8-0.6-0.40.3-0.30.5-0.20.0-0.10.1
Delta time in open arm before/after self-admin0.10.10.40.40.1-0.1-0.10.3-0.3-0.30.30.30.3-0.30.1-0.4-0.40.5-0.50.4-0.5-0.60.6-0.6
Diff in mean of infusions in LGA sessions0.20.30.90.8-0.60.61.00.7-0.7-0.70.70.70.6-0.60.6-0.6-0.40.4-0.40.5-0.4-0.10.1-0.1
Delay discount exponential model param0.30.51.0-0.30.4-0.4-0.1-0.60.60.6-0.6-0.6-0.60.7-0.60.60.8-0.80.8-0.70.80.9-1.00.9
Extinction: sum of active levers before priming2.03.03.92.0-1.41.41.51.9-1.9-1.91.91.91.9-1.91.8-1.8-1.81.8-1.81.7-1.7-1.51.5-1.4
Active lever presses in extinction session 60.50.51.50.9-1.21.21.10.7-0.7-0.60.60.60.6-0.61.0-0.6-0.30.2-0.20.8-0.6-0.1-0.3-0.3
Bone: final force1.21.92.51.5-1.31.31.51.6-1.6-1.51.51.51.5-1.51.5-1.5-1.41.3-1.31.2-1.1-1.01.0-0.7
Bone: final moment1.11.72.31.5-1.31.31.51.5-1.5-1.51.51.51.5-1.41.5-1.4-1.31.2-1.21.2-1.0-0.90.9-0.7
Food consumed during 24 hour testing period0.40.81.2-0.91.1-1.1-0.7-0.80.80.8-0.9-0.9-0.90.8-0.80.90.9-0.80.8-1.01.10.8-0.71.0
Glucose0.50.83.1-1.41.6-1.6-1.8-0.40.40.3-0.3-0.3-0.30.1-0.40.0-0.30.6-0.60.3-0.7-1.21.2-1.4
Heart weight0.40.72.3-0.30.1-0.2-0.40.5-0.5-0.60.70.70.7-0.70.3-0.8-1.01.1-1.10.8-1.0-1.41.5-1.3
Delay discount hyperbolic model param0.30.41.0-0.20.3-0.30.0-0.50.60.6-0.5-0.5-0.50.6-0.60.60.8-0.80.8-0.80.90.8-1.01.0
Intermittent access intake day 1-15 change0.84.26.6-2.62.5-2.5-2.2-2.22.22.2-2.1-2.1-2.12.1-2.12.11.9-1.81.8-2.01.81.3-1.21.3
Intermittent access intake escalation0.73.95.8-2.42.4-2.4-2.0-2.12.12.1-2.0-2.0-2.02.0-2.02.01.9-1.71.7-2.01.81.3-1.31.4
Intermittent access intake escalation 21.52.64.7-2.21.8-1.8-1.8-1.81.81.8-1.7-1.7-1.71.7-1.71.61.5-1.41.4-1.61.41.0-0.91.1
Intermitt. access day 1 inactive lever presses0.00.00.20.4-0.30.5-0.0-0.10.10.1-0.1-0.1-0.10.1-0.20.10.1-0.10.1-0.20.00.1-0.20.0
Intermitt. access day 15 inactive lever presses0.10.51.9-1.41.2-1.1-1.3-0.80.80.8-0.6-0.6-0.60.6-0.70.50.3-0.20.2-0.50.2-0.20.4-0.2
Intermitt. access escalation Index1.44.35.9-2.42.2-2.2-2.0-2.22.22.2-2.2-2.2-2.22.1-2.12.22.0-2.02.0-2.02.01.6-1.61.6
Intermittent access day 1 total infusions0.20.62.4-1.20.6-0.6-1.2-0.10.10.00.10.10.1-0.2-0.2-0.3-0.60.8-0.80.7-1.0-1.31.4-1.5
Intermittent access day 15 total infusions1.53.79.2-3.02.7-2.6-2.8-2.22.22.1-2.0-2.0-2.01.9-2.21.81.5-1.31.3-1.51.10.6-0.40.3
Intermittent access terminal intake (last 3 days)1.12.07.2-2.71.9-1.9-2.4-1.61.61.5-1.4-1.4-1.41.3-1.61.20.9-0.60.6-0.80.4-0.00.2-0.3
Intermittent access total infusions0.70.83.8-2.01.1-1.1-1.7-1.00.90.9-0.8-0.8-0.80.7-1.00.60.3-0.10.1-0.2-0.1-0.40.5-0.7
Intermittent access day 1 locomotion0.10.31.1-0.90.4-0.3-0.9-0.20.20.2-0.1-0.1-0.10.0-0.4-0.0-0.20.4-0.40.5-0.6-0.70.7-1.1
Intermittent access day 15 total locomotion0.93.410.5-3.22.8-2.8-2.7-2.02.02.0-1.8-1.8-1.81.8-1.91.71.3-1.11.1-1.20.90.4-0.30.2
Intermittent access total locomotion3.03.612.9-3.62.8-2.8-3.1-2.12.02.0-1.9-1.9-1.91.8-2.11.71.2-1.01.0-1.10.70.1-0.0-0.2
Intermittent access standard deviation0.10.51.6-1.30.8-0.8-1.0-0.90.90.8-0.7-0.7-0.70.8-0.80.70.6-0.50.5-0.60.50.2-0.20.2
Left kidney weight0.32.85.2-2.21.9-1.9-2.3-1.91.91.9-1.8-1.8-1.81.8-2.01.71.5-1.31.3-1.61.30.8-0.70.7
Right kidney weight0.53.44.0-2.02.0-2.0-1.9-2.02.01.9-1.9-1.9-1.91.9-2.01.91.7-1.71.7-2.01.81.3-1.21.5
Cocaine induced anxiety0.00.10.8-0.00.8-0.9-0.30.1-0.1-0.10.00.00.0-0.20.1-0.1-0.20.3-0.30.1-0.2-0.30.3-0.3
Post-drug Anxiety0.40.51.01.0-0.30.20.70.8-0.8-0.80.80.80.8-0.80.7-0.8-0.70.7-0.70.5-0.5-0.60.6-0.4
Baseline Anxiety0.20.41.51.0-1.21.21.00.6-0.5-0.50.60.60.6-0.50.6-0.5-0.40.3-0.30.3-0.3-0.10.10.0
Tail length0.10.73.31.6-1.21.21.80.7-0.7-0.70.60.60.6-0.50.7-0.5-0.1-0.10.10.10.30.7-0.70.9
Length with tail0.94.011.63.1-3.03.03.42.2-2.1-2.12.12.12.1-1.82.3-1.9-1.31.0-1.01.2-0.7-0.20.00.3
Length without tail0.73.69.32.7-3.03.12.92.0-2.0-1.92.02.02.0-1.72.1-1.8-1.31.1-1.11.2-0.9-0.40.3-0.0
Times rat made contact with spout1.01.11.50.9-0.70.70.61.2-1.2-1.21.11.11.1-1.21.1-1.1-1.21.2-1.21.0-1.0-1.21.2-0.9
Lifetime Intake0.30.41.8-1.30.5-0.4-1.2-0.70.70.7-0.5-0.5-0.50.5-0.70.40.2-0.10.1-0.0-0.2-0.30.4-0.7
Liver weight, left0.81.31.8-0.90.9-0.8-0.7-1.21.21.2-1.2-1.2-1.21.2-1.11.21.3-1.31.3-1.31.21.2-1.21.2
Liver weight, right1.32.32.7-1.41.5-1.5-1.4-1.71.71.7-1.7-1.7-1.71.6-1.61.61.6-1.51.5-1.61.51.3-1.21.2
Locomotor activity1.11.72.1-1.21.5-1.4-1.2-1.31.31.3-1.4-1.4-1.41.3-1.31.41.3-1.31.3-1.31.31.1-1.01.1
Locomotor testing distance0.82.12.6-1.21.3-1.2-1.3-1.51.51.5-1.6-1.6-1.61.5-1.51.61.5-1.51.5-1.51.41.3-1.11.2
Locomotor testing rearing0.10.51.8-1.11.3-1.3-1.3-0.70.70.7-0.7-0.7-0.70.6-0.70.60.4-0.30.3-0.30.1-0.00.0-0.3
Locomotion in novel chamber3.24.39.0-3.03.0-3.0-2.9-2.32.32.2-2.1-2.1-2.12.1-2.42.01.7-1.41.4-1.71.30.7-0.60.6
Locomotion in novel chamber post-restriction1.13.36.7-2.62.3-2.3-2.5-2.02.01.9-1.9-1.9-1.91.8-2.11.81.5-1.31.3-1.51.40.8-0.70.8
Fecal boli incidents, locomotor time 10.00.10.1-0.3-0.10.1-0.3-0.30.30.3-0.4-0.4-0.40.3-0.30.40.3-0.30.3-0.10.20.3-0.20.2
Change in fecal boli incidents, locomotor task0.20.20.40.7-0.40.40.30.4-0.4-0.40.40.40.4-0.40.5-0.4-0.40.4-0.40.4-0.5-0.40.4-0.5
Time >=10cm from walls, locomotor time 10.40.51.9-1.30.9-0.9-1.4-0.30.30.2-0.3-0.3-0.30.0-0.30.1-0.30.5-0.50.5-0.7-0.81.1-1.2
Bouts of movement, locomotor time 10.20.20.70.7-0.80.80.80.3-0.3-0.20.10.10.1-0.10.30.00.1-0.20.2-0.10.40.6-0.50.7
Total resting periods, locomotor time 10.10.20.60.3-0.40.40.4-0.10.10.1-0.2-0.2-0.20.2-0.00.30.4-0.40.4-0.40.50.7-0.60.8
Rest time, locomotor task time 11.93.03.6-1.71.5-1.4-1.5-1.91.91.9-1.9-1.9-1.91.9-1.81.91.8-1.71.7-1.81.71.6-1.41.5
Distance moved, locomotor task time 10.41.11.80.4-0.30.20.31.0-1.0-1.01.01.01.0-1.11.0-1.1-1.21.2-1.21.2-1.2-1.31.3-1.3
Vertical activity count, locomotor time 10.00.31.4-0.71.2-1.2-0.9-0.30.30.3-0.3-0.3-0.20.2-0.40.20.00.1-0.1-0.20.0-0.40.5-0.3
Time >=10cm from walls, locomotor time 20.10.40.6-0.80.4-0.3-0.4-0.70.70.7-0.8-0.8-0.80.7-0.50.80.7-0.70.7-0.50.50.8-0.60.4
Bouts of movement, locomotor time 20.10.41.91.1-1.31.40.70.6-0.6-0.50.50.50.5-0.50.5-0.4-0.40.3-0.30.4-0.4-0.10.1-0.1
Total resting periods, locomotor time 20.10.21.10.8-1.01.10.40.4-0.4-0.40.30.30.3-0.40.3-0.3-0.30.3-0.30.3-0.3-0.20.2-0.2
Rest time, locomotor task time 20.40.82.4-1.61.2-1.3-1.6-0.90.90.9-0.8-0.8-0.80.8-1.10.70.5-0.30.3-0.60.4-0.10.2-0.1
Distance moved, locomotor task time 20.20.21.10.9-0.60.61.10.4-0.4-0.30.30.30.3-0.20.6-0.20.0-0.10.10.10.10.5-0.50.4
Vertical activity count, locomotor time 20.41.02.50.30.2-0.10.3-0.70.80.8-0.8-0.8-0.80.9-0.60.91.2-1.31.3-1.21.31.6-1.61.6
Light reinforcement 10.31.42.1-1.41.4-1.4-1.0-1.31.21.2-1.2-1.2-1.21.2-1.11.21.2-1.11.1-1.11.11.0-1.00.9
Light reinforcement 21.43.14.1-2.01.8-1.8-1.6-2.02.02.0-1.8-1.8-1.82.0-1.91.81.8-1.71.7-1.71.61.3-1.31.2
Bone: marrow area0.30.73.6-1.51.4-1.4-1.9-0.70.70.6-0.6-0.6-0.60.4-0.80.40.00.2-0.2-0.1-0.2-0.70.9-0.8
Bone: maximum diameter0.20.30.6-0.60.7-0.7-0.5-0.50.50.5-0.6-0.6-0.60.5-0.60.60.5-0.50.5-0.70.70.4-0.40.7
Bone: maximum force2.65.16.01.9-1.91.91.52.4-2.4-2.42.32.32.3-2.42.3-2.4-2.42.4-2.42.3-2.3-2.32.3-2.1
Bone: maximum moment2.44.55.31.9-1.91.81.42.2-2.2-2.32.22.22.2-2.32.2-2.2-2.32.3-2.32.2-2.2-2.12.1-2.0
Mean time between licks in bursts0.10.40.80.9-0.90.90.90.7-0.7-0.70.70.70.7-0.70.8-0.7-0.60.5-0.50.6-0.4-0.30.2-0.2
Mean num. licks in bursts0.10.20.40.5-0.60.70.30.3-0.3-0.30.40.40.4-0.30.3-0.4-0.30.3-0.30.4-0.6-0.40.4-0.6
Cd content in liver1.31.42.8-1.61.6-1.6-1.7-1.31.31.3-1.3-1.3-1.31.2-1.21.21.0-0.90.9-0.90.80.5-0.40.3
Co content in liver1.82.13.4-1.00.7-0.7-0.5-1.41.41.5-1.4-1.4-1.41.5-1.31.51.7-1.71.7-1.41.41.9-1.81.5
Cu content in liver0.00.00.1-0.1-0.10.1-0.1-0.30.30.3-0.2-0.2-0.20.3-0.20.20.3-0.30.3-0.0-0.10.3-0.2-0.1
Fe content in liver0.10.10.40.6-0.60.70.50.3-0.3-0.30.30.30.3-0.30.3-0.3-0.20.2-0.20.3-0.3-0.00.0-0.2
K content in liver0.90.91.00.9-0.90.80.70.9-0.9-0.91.01.01.0-0.90.9-1.0-1.00.9-0.91.0-1.0-0.90.9-0.9
Mg content in liver0.10.10.4-0.50.4-0.4-0.6-0.20.20.2-0.1-0.1-0.10.1-0.20.1-0.00.1-0.10.0-0.2-0.30.4-0.4
Mn content in liver1.61.72.71.6-1.61.61.61.5-1.5-1.41.41.41.4-1.41.5-1.3-1.21.1-1.11.3-1.1-0.70.7-0.8
Na content in liver0.50.51.0-0.40.4-0.4-0.1-0.60.60.6-0.7-0.7-0.70.7-0.50.70.8-0.90.9-0.80.91.0-1.01.0
Rb content in liver0.20.31.4-1.00.8-0.8-1.2-0.40.40.3-0.3-0.3-0.30.2-0.40.2-0.00.2-0.20.0-0.2-0.50.7-0.6
Se content in liver0.10.10.5-0.30.1-0.2-0.40.0-0.0-0.00.10.10.1-0.10.0-0.1-0.30.3-0.30.3-0.5-0.50.6-0.7
Sr content in liver0.50.52.11.1-1.21.21.40.6-0.6-0.50.60.60.6-0.40.7-0.4-0.10.0-0.00.20.00.4-0.50.5
Zn content in liver0.10.10.50.6-0.60.60.70.2-0.2-0.10.20.20.2-0.10.3-0.10.1-0.20.20.00.10.4-0.40.3
Bone: minimum diameter0.30.62.2-0.90.8-0.9-1.5-0.0-0.0-0.1-0.0-0.0-0.0-0.3-0.2-0.2-0.60.8-0.80.5-0.7-1.31.4-1.3
Time in familiar zone, hab. session 10.20.20.8-0.70.7-0.7-0.9-0.30.30.3-0.4-0.4-0.40.2-0.30.30.10.0-0.00.1-0.3-0.20.3-0.6
Time in novel zone, hab. session 10.00.00.30.2-0.20.20.30.0-0.0-0.00.10.10.10.0-0.1-0.00.1-0.10.1-0.30.40.2-0.20.5
Total zone transitions, hab. session 10.40.60.80.7-0.60.60.80.9-0.9-0.90.90.90.9-0.90.8-0.9-0.80.8-0.80.7-0.6-0.70.6-0.4
Total locomotion distance, hab. session 10.20.30.8-0.90.9-0.9-0.9-0.50.50.5-0.5-0.5-0.50.4-0.60.40.3-0.20.2-0.40.20.00.00.0
Locomotion velocity, hab. session 10.00.10.2-0.50.5-0.5-0.4-0.20.20.2-0.3-0.3-0.20.2-0.20.20.1-0.10.1-0.20.10.0-0.00.0
Time in familiar zone, hab. session 20.10.10.30.4-0.20.10.50.2-0.2-0.20.00.00.0-0.10.30.10.1-0.20.2-0.10.30.4-0.50.5
Time in novel zone, hab. session 20.40.51.10.2-0.30.4-0.00.5-0.5-0.50.60.60.7-0.60.4-0.7-0.80.8-0.80.7-0.9-1.01.1-1.0
Total zone transitions, hab. session 24.45.67.61.7-1.71.61.12.3-2.4-2.42.42.42.4-2.52.1-2.5-2.62.7-2.72.5-2.6-2.82.7-2.6
Total locomotion distance, hab. session 20.71.02.10.2-0.30.2-0.10.8-0.8-0.90.90.90.9-1.00.7-1.0-1.21.2-1.21.1-1.2-1.41.4-1.4
Locomotion velocity, hab. session 20.40.61.7-0.10.0-0.0-0.40.5-0.5-0.60.60.60.6-0.70.4-0.7-0.91.0-1.00.9-1.0-1.31.3-1.3
Novel to familiar place preference ratio0.40.50.70.5-0.50.50.40.7-0.7-0.70.80.80.8-0.70.6-0.8-0.80.8-0.80.6-0.6-0.90.8-0.6
Novelty place preference0.20.30.60.2-0.20.20.10.4-0.4-0.40.50.50.5-0.50.3-0.6-0.60.6-0.60.4-0.5-0.80.8-0.5
Time in novel zone, NPP test0.20.30.70.2-0.30.30.20.5-0.5-0.50.60.60.6-0.50.4-0.7-0.60.7-0.70.4-0.5-0.80.8-0.6
Total zone transitions, NPP test1.62.43.01.2-1.11.00.91.7-1.7-1.71.61.61.6-1.71.6-1.6-1.71.7-1.71.7-1.6-1.61.6-1.5
Total locomotion distance, NPP test0.20.20.8-0.10.1-0.1-0.30.3-0.3-0.30.30.30.3-0.40.4-0.3-0.50.6-0.60.7-0.7-0.70.7-0.9
Locomotion velocity, NPP test0.10.10.5-0.20.1-0.2-0.30.2-0.2-0.20.10.10.1-0.30.3-0.2-0.30.4-0.40.5-0.6-0.50.5-0.7
Intraocular pressure1.21.92.7-0.90.7-0.7-0.8-1.41.41.4-1.5-1.5-1.51.4-1.41.51.5-1.61.6-1.61.61.6-1.51.6
Delta distance traveled before/after self-admin0.10.10.20.10.3-0.30.1-0.20.20.2-0.2-0.2-0.20.2-0.10.20.3-0.30.3-0.40.40.3-0.50.4
Delta ambulatory time before/after self-admin0.00.10.30.30.00.00.3-0.10.10.2-0.1-0.1-0.10.2-0.00.10.3-0.40.4-0.30.30.4-0.50.4
Parametrial fat weight1.43.38.8-2.92.9-3.0-2.7-1.91.91.8-1.8-1.8-1.81.7-2.01.61.2-1.01.0-1.30.90.2-0.20.2
Pavlov. Cond. lever latency0.30.30.5-0.50.4-0.3-0.4-0.70.70.7-0.6-0.6-0.60.7-0.70.60.6-0.60.6-0.70.60.5-0.50.5
Pavlov. Cond. magazine entry latency0.30.41.2-0.20.3-0.4-0.60.4-0.5-0.50.40.40.4-0.60.4-0.5-0.70.8-0.80.6-0.7-1.11.1-1.0
Pavlov. Cond. change in total contacts0.10.20.8-0.60.7-0.7-0.9-0.20.20.2-0.2-0.2-0.20.1-0.30.1-0.10.2-0.20.0-0.1-0.50.5-0.4
Pavlov. Cond. index score0.10.10.5-0.40.6-0.7-0.6-0.10.10.1-0.2-0.2-0.20.0-0.10.20.00.0-0.0-0.10.1-0.10.1-0.0
Pavlov. Cond. latency score0.10.10.2-0.20.4-0.5-0.40.1-0.1-0.20.00.00.0-0.20.2-0.1-0.20.3-0.30.2-0.2-0.40.4-0.3
Pavlov. Cond. lever contacts0.10.10.20.10.0-0.1-0.00.4-0.4-0.40.30.30.3-0.40.4-0.3-0.40.4-0.40.4-0.3-0.40.4-0.4
Pavlov. Cond. magazine entry number0.10.20.60.5-0.70.80.60.3-0.3-0.30.40.40.4-0.20.3-0.4-0.20.2-0.20.4-0.4-0.10.1-0.3
Pavlov. Cond. intertrial magazine entries0.60.71.2-0.40.4-0.3-0.2-0.90.90.9-0.9-0.9-0.90.9-0.80.91.0-1.01.0-0.90.91.1-1.10.9
Pavlov. Cond. lever-magazine prob. diff.0.00.10.4-0.30.5-0.6-0.5-0.00.00.0-0.2-0.2-0.2-0.0-0.00.1-0.10.1-0.1-0.00.0-0.20.2-0.1
Pavlov. Cond. response bias0.10.20.5-0.50.7-0.7-0.5-0.30.30.3-0.4-0.4-0.40.3-0.30.40.3-0.20.2-0.40.50.1-0.10.4
Pavlov. Cond. lever latency0.00.00.20.1-0.40.40.0-0.10.10.10.00.00.00.10.00.00.0-0.00.00.2-0.40.0-0.0-0.4
Pavlov. Cond. magazine entry latency3.95.56.72.2-2.01.91.92.6-2.6-2.62.52.52.5-2.62.4-2.5-2.52.5-2.52.3-2.2-2.22.2-1.8
Pavlov. Cond. change in total contacts0.30.81.50.4-0.20.20.31.0-1.0-1.00.90.90.9-1.00.7-1.0-1.11.2-1.20.9-0.7-1.21.2-0.8
Pavlov. Cond. index score0.91.52.01.0-0.70.60.81.4-1.4-1.41.31.31.3-1.41.2-1.4-1.41.4-1.41.1-1.0-1.31.3-0.8
Pavlov. Cond. latency score0.61.01.40.8-0.50.50.71.2-1.2-1.21.11.11.1-1.21.0-1.1-1.21.2-1.20.9-0.8-1.11.1-0.6
Pavlov. Cond. lever contacts0.00.00.1-0.00.3-0.40.00.2-0.2-0.20.10.10.1-0.20.1-0.2-0.20.2-0.2-0.10.2-0.20.20.2
Pavlov. Cond. magazine entry number5.06.57.9-2.52.3-2.2-2.1-2.82.82.8-2.7-2.7-2.72.8-2.62.82.7-2.62.6-2.52.32.3-2.32.0
Pavlov. Cond. intertrial magazine entries0.91.92.6-1.51.3-1.2-1.4-1.61.61.6-1.5-1.5-1.51.6-1.41.51.4-1.41.4-1.31.11.1-1.10.8
Pavlov. Cond. lever-magazine prob. diff.1.31.92.51.2-1.00.91.11.6-1.6-1.61.51.51.5-1.61.4-1.6-1.61.5-1.51.3-1.1-1.41.4-1.0
Pavlov. Cond. response bias1.11.52.11.0-0.80.70.81.4-1.4-1.41.31.31.3-1.41.2-1.4-1.41.4-1.41.1-1.0-1.31.3-0.9
Time in closed arm before self-admin0.10.20.9-1.00.6-0.6-0.9-0.50.50.4-0.3-0.3-0.30.3-0.50.20.1-0.00.00.1-0.3-0.40.3-0.6
Time in closed arm after self-admin0.10.10.3-0.60.00.0-0.2-0.30.30.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3-0.20.20.3-0.40.2
Time in open arm before self-admin0.10.10.60.6-0.20.20.80.4-0.4-0.30.20.20.2-0.20.5-0.1-0.0-0.10.1-0.10.40.5-0.40.7
Time in open arm after self-admin0.50.61.21.1-0.50.40.80.9-0.9-0.90.90.90.9-0.90.9-0.8-0.80.8-0.80.7-0.6-0.60.6-0.4
Bone: periosteal estimation0.00.10.4-0.50.5-0.5-0.6-0.30.30.2-0.3-0.3-0.30.2-0.30.20.1-0.00.0-0.30.2-0.10.20.0
Bone: periosteal perimeter0.10.20.7-0.30.3-0.3-0.60.2-0.2-0.20.20.20.2-0.30.0-0.3-0.50.6-0.60.4-0.5-0.80.8-0.7
Bone: post-yield work3.15.413.60.4-0.50.4-0.61.8-1.8-1.91.91.91.9-2.21.6-2.2-2.72.9-2.92.6-3.0-3.53.6-3.7
Progressive ratio test 1 active lever presses0.00.10.1-0.1-0.20.4-0.1-0.30.30.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3-0.00.00.4-0.3-0.0
Progressive ratio test 1 breakpoint0.00.10.2-0.1-0.30.4-0.1-0.20.20.3-0.3-0.3-0.30.2-0.20.30.3-0.30.3-0.00.00.4-0.3-0.0
Progressive ratio test 1 inactive lever presses0.00.00.20.0-0.30.5-0.0-0.10.10.2-0.1-0.1-0.10.1-0.10.10.1-0.10.10.2-0.30.2-0.2-0.3
Progressive ratio test 2 active lever presses0.60.92.2-1.51.0-0.9-1.4-1.11.11.1-1.0-1.0-1.01.0-1.10.90.8-0.70.7-0.60.30.3-0.2-0.1
Progressive ratio test 2 breakpoint0.70.92.2-1.51.0-0.9-1.3-1.21.11.1-1.0-1.0-1.01.0-1.11.00.8-0.70.7-0.60.40.4-0.30.0
Progressive ratio test 2 inactive lever presses1.54.812.2-3.52.7-2.6-3.0-2.52.52.5-2.3-2.3-2.32.3-2.52.11.8-1.61.6-1.61.30.9-0.60.4
Incentive Sensitization - Responses0.20.41.00.0-0.30.30.10.5-0.5-0.50.60.60.6-0.60.6-0.6-0.70.8-0.80.8-0.9-0.80.9-1.0
Incentive Sensitization - Breakpoint0.10.30.9-0.2-0.10.1-0.10.3-0.3-0.30.40.40.4-0.40.4-0.5-0.50.6-0.60.7-0.8-0.70.8-0.9
Sum of active levers in priming session hrs 5-62.22.14.4-0.40.8-0.8-0.1-1.21.21.3-1.4-1.4-1.41.4-1.01.51.7-1.81.8-1.61.72.1-2.12.0
Progressive ratio1.95.58.21.6-1.41.41.02.3-2.3-2.42.42.42.4-2.52.0-2.5-2.72.7-2.72.5-2.6-2.92.8-2.6
Food seeking constrained by brief footshock0.20.30.30.6-0.40.40.40.6-0.6-0.60.60.60.6-0.60.5-0.6-0.60.6-0.60.4-0.5-0.50.5-0.5
Seeking ratio, punishment vs. effort1.63.64.8-1.51.3-1.3-0.9-1.91.92.0-2.0-2.0-2.02.0-1.72.02.1-2.22.2-2.02.12.2-2.22.0
Retroperitoneal fat weight5.424.143.6-6.56.6-6.6-6.1-5.45.45.3-5.2-5.2-5.25.0-5.54.84.2-3.83.8-4.53.82.3-2.12.3
Reaction time number correct0.00.10.40.4-0.20.20.40.1-0.1-0.1-0.0-0.0-0.00.00.30.20.2-0.30.3-0.10.20.5-0.60.5
Reaction time mean minus median0.53.45.32.1-2.32.31.62.1-2.1-2.01.81.81.8-2.01.8-1.8-1.91.8-1.81.8-1.6-1.41.4-1.3
Reaction time mean minus median AUC0.31.83.81.8-1.91.91.41.6-1.6-1.51.31.31.3-1.51.4-1.2-1.31.2-1.21.3-1.0-0.60.7-0.7
Reaction time num false alarms0.30.51.8-0.10.2-0.20.2-0.40.50.5-0.6-0.6-0.60.6-0.50.70.7-0.80.8-0.81.11.1-1.11.3
Reaction time num false alarms AUC0.10.20.80.7-0.50.50.90.3-0.3-0.30.10.10.1-0.20.2-0.00.1-0.20.2-0.20.50.6-0.60.9
Reaction time trials correct on left0.00.10.40.4-0.20.20.40.1-0.1-0.1-0.0-0.0-0.00.00.30.20.2-0.30.3-0.10.20.5-0.60.5
Reaction time trials on left0.00.10.40.5-0.30.30.50.2-0.2-0.10.00.00.0-0.00.30.10.2-0.30.3-0.10.20.5-0.70.5
Reaction time mean0.10.30.6-0.00.1-0.10.00.5-0.5-0.50.40.40.4-0.60.4-0.5-0.70.7-0.70.5-0.5-0.70.8-0.6
Reaction time mean AUC0.10.30.7-0.10.1-0.1-0.10.4-0.5-0.50.40.40.4-0.50.3-0.5-0.60.7-0.70.5-0.5-0.70.8-0.7
Median of all reaction times0.10.20.6-0.60.7-0.7-0.40.1-0.2-0.20.20.20.2-0.30.1-0.3-0.40.5-0.50.2-0.4-0.70.8-0.6
Reaction time omissions1.52.43.81.9-1.91.91.81.8-1.8-1.71.61.61.6-1.71.7-1.5-1.41.3-1.31.4-1.2-0.90.7-0.7
Reaction time false alarm rate0.10.10.70.2-0.20.30.4-0.00.00.1-0.1-0.1-0.10.1-0.20.20.2-0.30.3-0.40.60.5-0.50.8
Reaction time premature initiation rate1.82.85.22.3-2.12.22.01.9-1.9-1.81.71.71.7-1.81.8-1.6-1.51.3-1.31.6-1.4-0.80.8-0.9
Reaction time premature initiations0.92.86.52.5-2.32.42.31.9-1.9-1.81.61.61.6-1.71.9-1.4-1.31.1-1.11.5-1.1-0.40.3-0.4
Std. dev. reaction times0.41.21.71.2-1.21.30.81.3-1.3-1.31.01.01.0-1.31.0-1.0-1.21.2-1.21.1-1.0-0.91.0-0.8
Reaction time trials completed0.00.10.40.5-0.30.30.50.2-0.2-0.10.00.00.0-0.00.30.10.2-0.30.3-0.10.20.5-0.70.5
Reaction time trials AUC0.00.10.30.4-0.20.20.40.1-0.1-0.10.00.00.0-0.00.30.10.2-0.30.3-0.10.20.5-0.60.4
Run reversals in cocaine runway, females1.61.82.40.9-0.90.90.91.4-1.4-1.41.41.41.4-1.41.4-1.4-1.41.4-1.41.5-1.5-1.31.3-1.5
Run reversals in cocaine runway, males0.20.30.80.3-0.30.30.3-0.30.30.4-0.3-0.3-0.30.4-0.30.40.6-0.70.7-0.70.60.8-0.90.9
Latency to leave start box in cocaine runway0.30.41.2-0.20.4-0.5-0.40.4-0.4-0.40.40.40.4-0.50.3-0.6-0.70.8-0.80.7-0.8-1.11.1-1.1
Latency to leave start box in cocaine runway, F0.40.51.1-0.20.1-0.3-0.20.5-0.5-0.50.60.60.6-0.60.5-0.6-0.80.9-0.90.8-0.9-1.11.1-1.0
Latency to leave start box in cocaine runway, M0.00.00.10.20.3-0.30.00.1-0.1-0.10.10.10.1-0.20.1-0.2-0.20.2-0.20.1-0.2-0.20.2-0.2
Std. dev. time between licks in bursts0.10.21.00.4-0.20.20.70.0-0.00.0-0.2-0.2-0.20.10.20.30.4-0.60.6-0.30.60.9-1.00.9
Total sessions with >9 infusions0.30.41.00.6-0.91.00.50.5-0.5-0.50.60.60.6-0.50.5-0.6-0.50.5-0.50.8-0.9-0.50.5-0.9
Short access day 1 total inactive lever presses0.71.42.7-1.61.5-1.4-1.5-1.31.31.3-1.3-1.3-1.31.2-1.31.21.0-0.90.9-1.00.80.6-0.50.5
Short access day 10 total inactive lever presses0.00.00.10.2-0.10.1-0.00.1-0.1-0.10.10.10.1-0.10.1-0.1-0.10.2-0.2-0.0-0.0-0.20.1-0.0
Short access day 1 total infusions0.20.30.8-0.90.3-0.1-0.8-0.80.80.8-0.6-0.6-0.60.7-0.80.50.5-0.40.4-0.40.00.20.1-0.2
Short access day 10 total infusions0.61.13.3-0.1-0.70.7-0.10.7-0.7-0.70.80.80.8-0.90.7-0.9-1.11.2-1.21.4-1.5-1.41.5-1.8
Short access total infusions0.30.41.30.1-0.70.90.10.4-0.4-0.40.50.50.5-0.50.4-0.6-0.60.7-0.70.8-1.0-0.80.9-1.1
Short access day 1 locomotion0.30.41.3-1.10.9-0.9-1.1-0.70.70.7-0.7-0.7-0.70.6-0.70.60.4-0.40.4-0.20.10.1-0.1-0.3
Short access day 10 total locomotion0.00.20.8-0.90.6-0.6-0.8-0.20.20.2-0.1-0.1-0.10.1-0.4-0.0-0.10.2-0.20.3-0.5-0.60.4-0.8
Short access total locomotion0.20.31.0-1.00.8-0.8-1.0-0.50.50.5-0.4-0.4-0.40.4-0.60.30.2-0.10.10.1-0.3-0.30.2-0.6
One hour access (0.3 mA shock)2.12.55.5-2.31.9-1.8-2.3-1.91.91.8-1.7-1.7-1.71.7-2.01.51.3-1.21.1-1.30.90.6-0.50.3
Compulsive drug intake0.91.36.32.5-2.02.11.91.1-1.1-1.01.01.01.0-0.91.0-0.8-0.50.3-0.30.5-0.30.2-0.30.3
One hour access (shock baseline)1.84.711.2-3.42.7-2.7-3.0-2.52.52.4-2.3-2.3-2.32.3-2.62.11.8-1.61.6-1.71.30.8-0.80.5
Social response proportion0.81.01.30.9-0.70.60.61.1-1.1-1.11.01.01.0-1.21.0-1.0-1.11.1-1.11.1-1.0-1.01.1-0.9
Social responses0.10.20.40.7-0.50.50.60.5-0.5-0.50.30.30.3-0.50.6-0.3-0.30.2-0.20.5-0.30.1-0.0-0.2
Social time0.50.82.01.2-1.41.41.00.9-0.8-0.80.80.80.8-0.80.9-0.8-0.70.6-0.60.8-0.8-0.40.5-0.6
Soleus weight4.613.716.4-4.03.9-3.8-3.6-4.04.04.0-4.0-4.0-4.03.9-3.93.93.7-3.53.5-3.63.32.9-2.82.6
Bone: stiffness2.03.64.81.4-1.41.41.01.9-2.0-2.02.02.02.0-2.01.8-2.1-2.12.2-2.21.9-1.9-2.22.2-1.9
Tibialis anterior weight2.910.134.24.9-5.45.45.83.2-3.2-3.03.13.13.1-2.63.6-2.6-1.61.1-1.11.8-1.00.5-0.80.8
Time to tail flick, vehicle, before self-admin1.31.62.70.5-0.50.40.51.2-1.2-1.21.31.31.3-1.31.1-1.3-1.41.5-1.51.3-1.5-1.61.6-1.5
Time to tail flick, vehicle, after self-admin1.83.74.51.8-1.91.91.41.9-1.9-2.02.02.02.0-2.01.8-2.0-2.02.0-2.02.1-2.1-1.91.8-2.0
Time to tail flick, test, before self-admin0.50.52.1-0.80.3-0.3-0.80.2-0.3-0.30.30.30.3-0.40.1-0.4-0.70.9-0.90.8-1.0-1.21.3-1.4
Time to tail flick, test, after self-admin0.00.10.3-0.5-0.0-0.0-0.2-0.20.20.2-0.2-0.2-0.20.20.00.20.2-0.20.2-0.20.30.2-0.30.3
Delta time to tail flick, vehicle, before/after SA0.91.02.01.1-1.41.40.91.0-1.0-1.01.01.01.0-1.01.0-1.0-0.90.9-0.91.1-1.0-0.70.6-0.9
Delta time to tail flick, test, before/after SA1.01.24.10.5-0.50.50.8-0.60.60.6-0.7-0.7-0.70.8-0.30.81.2-1.41.4-1.21.51.8-1.92.0
Tibia length0.20.72.6-0.00.2-0.20.5-0.40.50.5-0.5-0.5-0.50.6-0.50.70.9-1.01.0-1.01.31.3-1.31.6
Ambulatory time before self-admin0.20.51.20.40.0-0.1-0.00.6-0.7-0.70.60.60.6-0.70.5-0.7-0.90.9-0.90.8-0.8-1.01.1-1.0
Ambulatory time after self-admin0.10.21.0-0.71.0-1.0-0.9-0.30.20.2-0.2-0.2-0.20.1-0.30.0-0.10.2-0.20.0-0.2-0.60.5-0.6
Bone: tissue strength0.00.00.2-0.20.2-0.2-0.40.0-0.0-0.0-0.0-0.0-0.0-0.1-0.1-0.0-0.20.2-0.20.1-0.2-0.40.4-0.3
Total heroin consumption3.03.57.12.4-2.62.72.42.0-2.0-1.91.91.91.9-1.82.0-1.8-1.61.4-1.41.8-1.6-0.90.8-1.0
Bone: trabecular number2.24.26.81.2-0.70.60.62.1-2.1-2.12.02.02.0-2.21.8-2.2-2.42.5-2.52.2-2.2-2.62.6-2.3
Bone: trabecular spacing0.81.11.8-0.70.00.0-0.4-1.21.21.2-1.1-1.1-1.11.2-0.91.21.3-1.31.3-1.01.01.3-1.31.0
Bone: trabecular thickness0.50.72.1-0.10.6-0.7-0.60.5-0.5-0.60.50.50.6-0.70.3-0.7-0.91.1-1.10.8-0.9-1.41.4-1.2
Bone: trabecular tissue density6.110.712.5-3.53.3-3.2-3.0-3.53.53.5-3.5-3.5-3.53.5-3.53.43.3-3.23.2-3.33.12.7-2.62.5
Water consumed over 24 hours0.71.41.81.2-1.11.01.11.3-1.3-1.31.31.31.3-1.31.1-1.3-1.31.2-1.21.0-0.9-1.11.1-0.7
Number of responses in last shaping day0.00.00.30.3-0.40.50.30.1-0.1-0.0-0.0-0.0-0.0-0.00.20.00.1-0.10.10.3-0.20.2-0.2-0.2