Hub : Genes

Nedd4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Nedd4 0.24 0.13 1.2e-05 0.04 0.07 0.09 0.08 4.7e-03 8.1e-05 1.4e-05 5.6e-05
2 PL mRNA stability Nedd4 0.1 0.05 7.7e-09 0.07 0.08 0.08 0.07 1.5e-08 8.9e-09 6.9e-09 1.3e-08
3 pVTA mRNA stability Nedd4 0.07 0.05 3.1e-05 0.06 0.04 0.05 0.05 1.3e-05 1.5e-04 4.6e-05 4.9e-05
4 NAcc mRNA stability Nedd4 0.05 0.03 9.7e-07 0.04 0.04 0.04 0.04 2.3e-07 8.1e-07 7.6e-07 8.3e-07
5 OFC alternative TSS XM_039080889.1 0.22 0.13 9.0e-03 0.09 0.01 -0 0.04 3.6e-03 1.8e-01 4.3e-01 4.6e-02
6 Brain mRNA stability Nedd4 0.19 0.09 5.4e-09 0.09 0.1 0.11 0.1 1.8e-08 1.5e-09 3.5e-10 9.5e-10
7 Brain gene expression Nedd4 0.1 0.07 3.8e-08 0.07 0.09 0.08 0.08 4.8e-07 1.0e-08 6.8e-08 8.4e-08
8 Adipose mRNA stability Nedd4 0.24 0.11 2.0e-14 0.1 0.11 0.1 0.1 1.4e-11 1.3e-12 1.7e-11 1.3e-11
9 NAcc gene expression Nedd4 0.05 0.03 2.3e-06 0.04 0.04 0.03 0.04 3.2e-07 3.7e-07 5.1e-06 7.1e-07
10 Adipose gene expression Nedd4 0.45 0.14 1.1e-16 0.14 0.13 0.12 0.14 5.6e-15 2.1e-14 4.0e-13 4.7e-15
11 Brain alternative TSS XM_063264950.1 0.03 0.02 2.4e-03 0.03 0.02 0.02 0.02 6.0e-04 2.9e-03 4.8e-03 2.8e-03
12 Liver gene expression Nedd4 0.07 0.05 9.1e-07 0.04 0.04 0.03 0.04 1.3e-05 1.1e-05 1.2e-04 8.8e-05
13 Adipose isoform ratio XM_039080889.1 0.04 0.03 2.2e-03 0 0 0 0 1.2e-01 7.5e-02 7.5e-02 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.3-0.5-0.5-0.4-0.50.5-0.5-0.0-0.40.10.0-0.6-0.10.3
Area under the delay curve0.40.51.30.30.20.00.20.10.40.70.80.80.8-1.1-1.11.2
BMI with tail5.117.528.14.14.95.05.1-5.13.45.34.34.23.51.1-3.82.4
BMI without tail1.02.96.01.31.92.32.4-2.40.72.51.42.00.81.1-1.30.4
Body weight3.816.526.04.44.54.24.2-4.13.45.14.14.64.30.2-4.23.2
Weight adjusted by age2.33.58.02.12.62.82.4-2.61.51.71.41.00.72.2-0.6-0.2
Bone surface0.00.10.20.30.30.40.4-0.50.10.40.10.20.10.2-0.1-0.1
Bone volume0.10.20.50.40.50.50.5-0.50.30.70.40.50.6-0.1-0.50.4
Breakpoint value in progressive ratio session0.10.10.3-0.5-0.2-0.40.1-0.2-0.50.3-0.00.50.2-0.0-0.20.4
Number of licking bursts2.23.55.4-2.0-1.9-1.9-1.91.9-1.8-2.3-2.1-1.7-2.20.31.9-1.8
Context. condit. distance diff. score0.30.31.30.10.0-0.1-0.00.00.70.40.60.40.7-1.2-0.80.9
Locomotion velocity, session 10.91.04.40.71.01.21.2-1.20.40.10.0-0.3-0.62.10.7-1.2
Locomotion distance, session 10.70.91.9-1.0-0.7-0.7-0.50.5-0.8-1.1-0.8-1.2-1.40.81.1-1.1
Locomotion velocity, session 20.10.11.0-0.5-0.3-0.2-0.30.2-1.00.1-0.40.0-0.30.30.3-0.0
Locomotion distance, session 20.30.51.8-1.1-0.5-0.2-0.20.1-1.3-0.1-0.7-0.2-1.00.80.6-0.7
Locomotion velocity, session 32.02.34.2-1.8-1.3-0.5-0.60.5-1.7-1.3-1.5-1.8-2.01.62.0-1.8
Locomotion distance, session 33.23.55.8-2.4-2.2-1.9-2.02.0-2.3-2.0-2.0-1.5-2.00.01.6-1.3
Stereotopy head waving bouts, day 30.80.92.11.31.31.21.2-1.21.50.51.0-0.00.60.8-0.20.1
Stereotopy head waving duration, day 31.61.93.81.81.81.81.7-1.72.01.01.40.11.01.0-0.40.3
Locomotion velocity, session 70.70.81.2-1.0-1.1-1.1-1.11.1-0.9-1.0-0.5-1.1-0.6-0.50.6-0.3
Locomotion distance, session 72.02.54.1-2.0-1.8-1.6-1.51.5-1.8-1.7-1.6-1.5-1.70.01.5-1.2
Stereotopy head waving bouts, day 70.40.41.70.30.61.10.9-0.90.20.40.2-0.0-0.31.30.2-0.7
Stereotopy head waving duration, day 70.50.62.70.30.51.10.9-0.90.20.2-0.0-0.5-0.51.70.7-1.0
Locomotion velocity, session 80.20.20.7-0.2-0.10.20.3-0.3-0.50.1-0.5-0.2-0.50.90.7-0.7
Locomotion distance, session 80.71.03.0-1.7-1.3-1.0-0.90.9-1.5-0.6-1.2-0.2-1.1-0.30.7-0.5
Degree of sensitization distance0.00.00.1-0.2-0.2-0.2-0.10.1-0.1-0.2-0.1-0.4-0.2-0.10.3-0.2
Degree of sensitization stereotypy0.30.31.50.10.40.90.7-0.7-0.00.30.0-0.0-0.41.20.3-0.7
Conditioned locomotion1.61.85.00.90.80.40.4-0.40.71.41.81.21.8-1.5-2.02.2
Cocaine response after cond. corrected3.64.47.52.62.72.72.7-2.72.61.82.20.71.41.5-0.90.2
Cocaine response after cond. not corrected3.03.56.22.42.42.32.4-2.42.51.52.00.61.31.2-0.90.2
Cocaine response before conditioning0.50.61.4-1.0-1.0-1.2-1.21.1-0.9-0.5-0.60.2-0.3-1.0-0.10.3
Saline control response0.40.61.90.00.10.30.3-0.30.2-0.7-0.3-1.4-0.81.31.1-1.1
Bone: connectivity density1.82.84.6-2.2-2.0-1.5-1.71.6-2.1-1.6-2.1-1.3-1.90.11.6-1.2
Bone: cortical apparent density0.60.81.7-0.9-0.9-1.0-1.11.1-0.5-1.3-0.7-0.9-0.8-0.10.8-0.5
Bone: cortical area2.13.27.02.62.21.61.5-1.42.61.02.6-0.22.1-0.3-1.31.5
Bone: cortical porosity0.40.41.6-0.1-0.5-0.9-0.80.8-0.1-0.20.2-0.30.5-1.3-0.40.9
Bone: cortical porosity0.80.94.0-0.2-0.7-1.2-1.11.1-0.30.00.20.10.8-2.0-0.71.4
Bone: cortical thickness0.40.72.01.00.6-0.0-0.00.11.4-0.31.4-1.11.0-0.7-0.51.0
Bone: cortical thickness0.30.41.10.80.50.00.1-0.11.1-0.11.0-0.80.9-0.4-0.30.8
Bone: cortical tissue density0.70.91.8-1.1-1.0-1.1-1.11.1-0.7-1.4-0.8-0.9-0.9-0.10.8-0.5
Condit. Reinf. active minus inactive responses1.41.53.3-1.4-1.3-1.4-1.41.4-1.70.1-0.91.4-0.1-1.8-0.70.9
Condit. Reinf. active-inactive response ratio0.90.93.70.30.0-0.6-0.60.60.40.30.61.01.1-1.9-1.31.6
Condit. Reinf. active responses1.62.06.1-2.2-1.8-1.4-1.31.3-2.5-0.1-1.71.0-1.1-0.80.2-0.3
Condit. Reinf. inactive responses2.93.58.1-2.7-2.0-0.9-0.80.8-2.8-0.8-2.4-0.6-2.51.41.9-2.3
Incentive salience index mean1.21.54.3-1.2-1.1-1.2-1.21.1-1.40.6-0.41.70.3-2.1-1.11.3
Condit. Reinf. lever presses0.71.03.3-1.1-0.9-1.0-0.90.9-1.10.6-0.21.20.3-1.8-1.01.1
Condit. Reinf. active minus inactive responses1.31.73.71.41.41.41.5-1.51.01.90.61.91.20.4-1.00.5
Condit. Reinf. active-inactive response ratio2.22.64.72.22.01.61.7-1.61.81.71.51.41.80.2-1.31.0
Condit. Reinf. active responses0.91.34.90.81.00.91.0-1.00.51.80.42.21.1-0.3-1.30.8
Condit. Reinf. inactive responses0.81.02.3-1.5-1.3-1.0-1.11.0-1.5-0.1-1.30.9-0.7-0.9-0.0-0.2
Condit. Reinf. lever presses0.30.41.00.60.2-0.1-0.20.20.90.20.60.31.0-1.0-0.60.9
Condit. Reinf. lever reinforcers received0.91.24.20.80.90.80.8-0.90.61.70.62.11.3-0.5-1.31.0
Conditioned reinforcement - actives0.00.10.20.20.10.20.4-0.40.40.00.3-0.30.40.40.10.2
Conditioned reinforcement - inactives0.20.31.00.50.20.60.7-0.71.0-0.20.5-0.80.20.60.2-0.2
Conditioned locomotion0.50.62.00.1-0.2-0.4-0.20.20.30.50.70.61.1-1.4-1.01.4
Patch foraging indifference point 0 sec0.10.21.10.20.40.50.1-0.2-0.3-0.20.0-0.3-0.51.10.6-0.6
Patch foraging indifference point AUC2.02.87.4-2.5-2.3-1.9-1.71.7-2.7-0.7-2.20.6-1.5-0.80.5-0.5
Delay disc. indifference point, 0s delay1.41.53.2-1.8-1.7-1.5-1.31.8-1.7-0.6-1.20.3-0.6-1.10.10.3
Delay disc. indifference point, 16s delay1.11.23.20.70.5-0.0-0.10.20.90.81.30.91.4-1.8-1.61.8
Delay disc. indifference point, 2s delay0.10.10.2-0.1-0.3-0.20.10.40.1-0.4-0.2-0.4-0.2-0.10.2-0.1
Delay disc. indifference point, 24s delay0.10.10.6-0.0-0.2-0.3-0.20.30.10.20.30.10.4-0.8-0.50.6
Delay disc. indifference point, 4s delay0.60.62.5-0.4-0.6-0.7-0.50.7-0.10.40.30.80.7-1.6-1.01.2
Delay disc. indifference point, 8s delay0.30.30.90.10.30.30.5-0.30.20.80.51.00.3-0.5-0.90.6
Indifference point function ln k2.13.78.62.82.72.22.2-2.12.91.12.2-0.01.51.2-0.80.5
Indifference point function log k2.13.78.62.82.72.22.2-2.12.91.12.2-0.01.51.2-0.80.5
Patch foraging total patch changes 0 sec0.20.31.30.40.60.70.3-0.4-0.0-0.20.2-0.4-0.41.20.5-0.6
Patch foraging total patch changes 12 sec0.91.12.7-1.4-1.3-1.0-1.00.9-1.6-0.8-1.2-0.6-1.3-0.10.9-0.9
Patch foraging total patch changes 18 sec0.10.20.5-0.3-0.2-0.3-0.40.3-0.7-0.6-0.4-0.3-0.70.30.4-0.3
Patch foraging total patch changes 24 sec1.01.83.6-1.4-1.1-0.7-0.90.7-1.8-1.2-1.6-0.8-1.91.21.6-1.8
Patch foraging total patch changes 6 sec1.11.65.2-1.7-1.3-0.8-0.90.9-2.3-0.6-1.70.2-1.70.50.9-1.2
Patch foraging time to switch 0 sec0.30.52.2-0.5-0.9-1.0-1.00.9-0.2-0.20.1-0.50.4-1.5-0.20.6
Patch foraging water rate 0 sec0.81.73.81.61.91.91.8-1.81.30.90.90.60.51.5-0.3-0.2
Patch foraging water rate 12 sec1.63.48.02.02.42.72.6-2.51.71.00.70.5-0.02.80.3-1.3
Patch foraging water rate 18 sec0.40.71.51.11.21.21.0-1.01.00.30.40.10.11.00.1-0.4
Patch foraging water rate 24 sec0.70.93.2-0.4-0.3-0.10.10.0-0.4-1.0-1.3-0.8-1.51.11.3-1.8
Patch foraging water rate 6 sec0.40.62.40.81.01.01.0-1.00.60.1-0.10.1-0.31.50.3-0.9
Seeking ratio, delayed vs. immediate footshock0.50.61.20.81.10.81.0-1.00.41.00.61.10.50.3-0.60.3
Distance traveled before self-admin0.00.00.10.20.1-0.0-0.00.0-0.0-0.20.0-0.3-0.00.20.2-0.0
Distance traveled after self-admin1.62.04.01.91.81.71.8-1.82.00.71.5-0.40.41.5-0.1-0.5
Extensor digitorum longus weight4.819.131.24.75.15.55.6-5.63.65.63.84.43.51.7-3.31.9
Bone: elastic displacement0.20.20.90.20.30.10.2-0.20.10.50.11.00.4-0.3-0.60.5
Bone: elastic work0.60.82.00.70.50.10.00.00.60.90.71.21.3-1.2-1.31.4
Bone: endosteal estimation1.53.35.82.22.42.42.2-2.31.92.01.81.21.40.8-1.20.6
Bone: endosteal perimeter3.06.49.42.93.03.02.8-2.82.53.12.52.22.40.1-2.21.7
Epididymis fat weight0.20.71.7-1.3-1.2-0.4-0.40.6-1.2-0.3-1.0-0.3-0.80.30.8-0.7
Delta time in closed arm before/after self-admin0.10.10.40.1-0.2-0.5-0.30.30.2-0.10.3-0.00.4-0.6-0.30.5
Delta time in open arm before/after self-admin1.01.02.2-0.7-0.8-0.4-0.60.6-0.7-1.2-1.1-1.4-1.10.81.5-1.3
Diff in mean of infusions in LGA sessions1.51.85.00.20.40.30.7-0.80.51.91.12.21.7-1.5-1.91.7
Delay discount exponential model param0.30.41.0-0.3-0.3-0.1-0.3-0.0-0.4-0.6-0.7-0.7-0.70.91.0-1.0
Extinction: sum of active levers before priming0.40.41.4-0.3-0.10.1-0.10.0-0.6-0.6-0.5-0.8-0.61.21.0-0.7
Active lever presses in extinction session 60.20.20.60.30.40.20.7-0.80.20.60.20.50.50.5-0.20.2
Bone: final force1.32.23.61.91.71.31.3-1.21.91.51.90.71.8-0.5-1.41.4
Bone: final moment1.52.34.32.01.71.21.2-1.12.11.42.10.51.9-0.7-1.51.6
Food consumed during 24 hour testing period1.21.63.81.92.01.51.5-1.51.70.20.9-0.20.11.60.2-0.5
Glucose0.30.52.4-0.10.30.60.6-0.60.0-0.2-0.4-0.4-0.91.60.8-1.2
Heart weight0.50.85.20.00.30.60.6-0.6-0.41.5-0.02.30.5-0.6-1.10.6
Delay discount hyperbolic model param0.40.41.2-0.2-0.20.0-0.2-0.2-0.4-0.6-0.7-0.7-0.71.01.0-1.1
Intermittent access intake day 1-15 change0.20.51.3-0.1-0.30.30.5-0.60.5-0.5-0.2-1.1-0.71.00.9-1.1
Intermittent access intake escalation0.20.30.70.2-0.00.50.8-0.80.8-0.00.2-0.7-0.30.70.5-0.8
Intermittent access intake escalation 20.60.71.91.11.00.91.1-1.11.40.61.10.00.50.5-0.40.1
Intermitt. access day 1 inactive lever presses0.10.21.00.0-0.3-0.2-0.30.31.0-0.40.4-0.60.2-0.6-0.10.3
Intermitt. access day 15 inactive lever presses0.30.61.20.90.70.71.0-1.01.10.80.80.51.00.2-0.60.5
Intermitt. access escalation Index0.40.61.80.61.00.80.00.0-0.30.80.51.30.6-0.4-1.01.1
Intermittent access day 1 total infusions0.40.62.4-0.3-0.8-0.9-0.70.8-0.1-1.4-0.4-1.6-0.6-0.10.9-0.4
Intermittent access day 15 total infusions0.30.41.5-0.4-0.9-0.7-0.40.40.1-0.9-0.3-1.2-0.4-0.10.7-0.4
Intermittent access terminal intake (last 3 days)0.10.20.60.2-0.3-0.4-0.10.00.7-0.40.4-0.80.3-0.5-0.00.3
Intermittent access total infusions0.40.42.40.0-0.5-0.3-0.20.20.3-1.1-0.1-1.6-0.40.50.9-0.5
Intermittent access day 1 locomotion0.91.12.4-0.8-1.3-1.2-1.21.3-0.5-1.5-0.8-1.6-0.6-0.60.9-0.3
Intermittent access day 15 total locomotion0.10.30.90.6-0.1-0.2-0.20.20.9-0.50.6-0.80.6-0.5-0.10.5
Intermittent access total locomotion0.10.10.50.40.20.30.3-0.20.7-0.30.2-0.60.20.30.3-0.0
Intermittent access standard deviation0.20.41.30.80.40.40.6-0.61.1-0.40.7-1.20.10.90.3-0.2
Left kidney weight1.67.212.53.43.53.53.5-3.43.22.62.41.51.82.0-1.40.4
Right kidney weight0.93.98.72.02.43.02.8-2.71.81.91.11.40.62.5-0.5-0.5
Cocaine induced anxiety0.30.41.5-0.3-0.2-0.5-0.50.5-0.40.30.40.50.7-1.1-0.81.2
Post-drug Anxiety2.62.84.8-2.2-2.1-2.1-1.91.9-1.9-1.7-1.7-1.2-1.6-0.41.2-0.7
Baseline Anxiety4.14.88.4-2.2-2.0-1.4-1.61.4-2.1-2.4-2.8-1.9-2.91.52.8-2.7
Tail length0.62.55.0-1.6-1.8-1.5-1.51.5-1.8-1.7-2.2-1.0-1.50.71.8-1.4
Length with tail0.10.31.01.00.60.50.4-0.30.40.50.00.70.80.6-0.20.3
Length without tail3.210.415.74.03.83.23.0-2.93.23.63.23.43.80.2-3.22.8
Times rat made contact with spout0.20.20.60.40.50.10.1-0.20.5-0.60.3-0.8-0.50.50.2-0.5
Lifetime Intake0.30.42.1-0.1-0.5-0.2-0.20.20.2-1.0-0.2-1.4-0.40.50.9-0.5
Liver weight, left1.42.45.01.51.92.22.2-2.21.11.50.81.60.41.8-0.6-0.4
Liver weight, right0.61.02.70.70.91.51.6-1.60.91.20.60.80.31.0-0.3-0.4
Locomotor activity4.26.611.13.33.33.22.9-2.82.62.82.71.82.41.0-1.91.4
Locomotor testing distance2.74.98.92.93.02.92.6-2.62.42.12.11.21.71.5-1.30.6
Locomotor testing rearing0.40.81.61.01.11.21.2-1.20.81.10.31.00.30.9-0.4-0.2
Locomotion in novel chamber0.20.20.80.60.2-0.00.0-0.10.9-0.10.9-0.40.7-0.2-0.40.6
Locomotion in novel chamber post-restriction0.20.41.8-0.6-0.7-0.8-0.60.7-0.40.1-0.20.50.2-1.4-0.40.4
Fecal boli incidents, locomotor time 10.30.41.1-0.7-0.4-0.7-0.70.7-0.8-0.2-0.20.20.0-1.1-0.30.9
Change in fecal boli incidents, locomotor task1.91.84.91.91.61.61.4-1.62.20.21.3-0.70.61.70.1-0.4
Time >=10cm from walls, locomotor time 10.80.81.30.60.80.60.6-1.10.71.01.10.81.1-0.6-1.11.0
Bouts of movement, locomotor time 10.00.10.1-0.20.30.10.1-0.1-0.30.20.20.4-0.20.3-0.30.2
Total resting periods, locomotor time 10.00.00.2-0.10.30.00.0-0.0-0.3-0.00.20.2-0.30.4-0.10.1
Rest time, locomotor task time 10.40.52.50.50.60.1-0.50.10.30.11.10.30.9-0.6-1.01.6
Distance moved, locomotor task time 10.50.81.7-1.2-1.2-0.6-0.40.8-1.1-0.5-1.3-0.5-0.70.21.0-1.0
Vertical activity count, locomotor time 10.10.30.7-0.5-0.6-0.7-0.30.8-0.7-0.1-0.80.4-0.1-0.50.2-0.2
Time >=10cm from walls, locomotor time 20.20.21.00.30.60.50.1-0.30.30.30.70.30.7-0.0-0.61.0
Bouts of movement, locomotor time 20.20.20.8-0.30.30.60.3-0.4-0.50.3-0.30.3-0.80.90.3-0.7
Total resting periods, locomotor time 20.20.31.1-0.30.30.70.4-0.5-0.50.2-0.30.2-1.01.10.4-0.9
Rest time, locomotor task time 20.10.10.30.30.1-0.3-0.50.00.3-0.50.5-0.6-0.3-0.3-0.00.2
Distance moved, locomotor task time 20.70.82.0-1.1-0.9-0.3-0.40.7-1.3-0.4-1.4-0.5-0.70.81.1-1.0
Vertical activity count, locomotor time 20.81.02.0-0.9-0.9-0.9-0.81.4-1.1-1.2-1.4-1.0-0.70.41.3-0.7
Light reinforcement 11.33.27.11.51.91.81.8-1.81.02.51.72.71.6-0.2-2.11.4
Light reinforcement 20.30.51.51.10.7-0.10.0-0.11.2-0.41.1-0.60.7-0.2-0.40.8
Bone: marrow area1.73.66.42.42.52.52.3-2.42.02.01.91.21.50.7-1.20.7
Bone: maximum diameter3.76.912.73.63.53.13.0-2.93.22.33.20.92.40.6-1.81.4
Bone: maximum force1.32.33.71.81.71.41.2-1.21.81.61.90.91.9-0.7-1.51.5
Bone: maximum moment1.42.54.32.01.71.31.2-1.12.01.52.10.72.1-0.8-1.61.6
Mean time between licks in bursts0.10.30.8-0.1-0.4-0.9-0.80.8-0.1-0.7-0.6-0.3-0.1-0.50.20.1
Mean num. licks in bursts2.33.65.82.42.42.12.0-2.12.31.82.40.91.90.3-1.61.4
Cd content in liver1.21.33.5-1.4-1.5-1.5-1.41.5-1.9-0.4-1.10.5-0.3-1.2-0.10.4
Co content in liver1.11.23.8-0.4-0.6-1.1-1.11.2-0.70.20.31.20.9-1.9-1.31.8
Cu content in liver0.30.41.00.20.20.10.1-0.10.30.80.70.80.9-0.7-1.01.0
Fe content in liver0.30.41.2-0.00.30.50.5-0.5-0.1-0.3-0.2-0.8-1.01.10.8-1.0
K content in liver0.50.51.30.60.60.80.9-0.80.31.20.31.00.60.3-0.50.2
Mg content in liver0.50.51.40.60.60.70.8-0.70.31.10.31.20.70.2-0.70.2
Mn content in liver2.32.65.42.21.71.11.2-1.12.31.22.20.52.1-0.6-1.51.7
Na content in liver1.51.73.51.21.71.81.9-1.90.71.60.91.20.41.2-0.60.0
Rb content in liver0.40.41.30.40.50.91.0-1.00.20.60.2-0.1-0.21.10.3-0.6
Se content in liver0.40.51.4-0.1-0.2-0.1-0.10.1-0.1-0.8-0.5-1.2-0.81.11.1-1.0
Sr content in liver0.70.61.5-0.9-0.9-1.0-1.01.1-1.2-0.6-1.00.1-0.5-0.60.40.1
Zn content in liver0.60.72.60.20.20.0-0.10.10.01.10.41.61.1-1.0-1.31.1
Bone: minimum diameter1.73.05.72.01.71.00.8-0.81.91.52.40.92.3-1.6-2.12.3
Time in familiar zone, hab. session 10.50.41.10.30.3-0.10.2-0.10.20.70.80.80.9-0.9-1.01.0
Time in novel zone, hab. session 10.30.31.1-0.2-0.20.0-0.20.20.1-0.7-0.4-1.0-0.50.60.8-0.6
Total zone transitions, hab. session 11.31.83.4-1.7-1.2-0.8-0.80.8-1.7-1.4-1.4-1.2-1.91.11.5-1.5
Total locomotion distance, hab. session 10.91.32.7-1.4-1.1-0.5-0.50.5-1.5-0.9-1.4-0.7-1.61.11.2-1.5
Locomotion velocity, hab. session 10.60.92.0-1.1-0.7-0.2-0.20.2-1.1-0.7-1.1-0.5-1.41.21.0-1.4
Time in familiar zone, hab. session 20.40.50.9-0.6-0.6-0.5-0.30.3-0.5-0.8-0.7-0.7-0.90.70.9-0.9
Time in novel zone, hab. session 20.80.91.61.21.20.80.7-0.71.20.61.30.21.1-0.4-0.90.9
Total zone transitions, hab. session 20.60.72.7-1.4-0.9-0.5-0.50.5-1.70.2-1.11.0-0.9-0.1-0.0-0.4
Total locomotion distance, hab. session 20.40.51.8-1.1-0.6-0.2-0.30.3-1.30.5-0.81.3-0.6-0.4-0.4-0.1
Locomotion velocity, hab. session 20.30.41.4-1.0-0.5-0.3-0.30.3-1.10.5-0.61.2-0.4-0.5-0.50.0
Novel to familiar place preference ratio1.31.42.61.01.11.11.0-1.00.81.61.21.41.4-0.7-1.41.3
Novelty place preference1.61.73.11.21.31.21.1-1.11.01.71.41.51.6-0.7-1.51.5
Time in novel zone, NPP test1.92.13.11.51.61.41.3-1.41.31.81.61.41.6-0.4-1.51.4
Total zone transitions, NPP test0.30.41.2-0.9-0.3-0.2-0.10.1-1.1-0.1-0.70.4-1.00.60.2-0.6
Total locomotion distance, NPP test0.50.61.8-1.0-0.40.00.0-0.0-1.1-0.2-1.00.1-1.30.90.7-1.2
Locomotion velocity, NPP test0.91.33.0-1.6-1.0-0.5-0.50.5-1.7-0.6-1.5-0.2-1.70.91.1-1.5
Intraocular pressure0.10.10.3-0.1-0.2-0.3-0.40.2-0.5-0.1-0.50.2-0.20.00.2-0.2
Delta distance traveled before/after self-admin2.42.66.12.11.91.92.2-2.12.51.11.50.10.61.5-0.4-0.5
Delta ambulatory time before/after self-admin2.12.67.22.31.81.82.0-2.02.71.11.8-0.00.91.1-0.5-0.3
Parametrial fat weight1.43.25.0-1.9-2.0-2.0-2.12.2-2.0-2.2-2.0-1.6-1.70.11.6-0.9
Pavlov. Cond. lever latency0.81.13.51.51.21.01.0-1.01.9-0.30.9-1.00.41.00.4-0.4
Pavlov. Cond. magazine entry latency3.64.616.5-1.9-2.0-2.4-2.32.2-1.90.6-0.52.00.9-4.1-1.92.6
Pavlov. Cond. change in total contacts1.41.55.1-1.2-1.1-1.2-1.11.1-1.20.6-0.21.40.5-2.3-1.31.5
Pavlov. Cond. index score2.73.57.4-2.3-2.2-2.3-2.32.2-2.5-0.1-1.21.1-0.2-2.7-0.81.3
Pavlov. Cond. latency score2.32.96.0-2.3-2.1-2.1-2.12.0-2.4-0.1-1.31.0-0.4-2.3-0.61.0
Pavlov. Cond. lever contacts1.11.32.9-1.4-1.2-1.3-1.21.2-1.70.4-0.61.2-0.0-1.7-0.81.0
Pavlov. Cond. magazine entry number3.24.014.21.92.02.42.3-2.21.9-0.30.7-1.6-0.63.81.6-2.2
Pavlov. Cond. intertrial magazine entries1.72.15.8-1.3-0.9-0.1-0.10.1-1.2-1.1-1.7-1.0-2.02.01.9-2.4
Pavlov. Cond. lever-magazine prob. diff.2.73.37.3-2.3-2.1-2.2-2.22.1-2.40.1-1.21.4-0.1-2.7-0.91.4
Pavlov. Cond. response bias2.83.512.8-1.6-1.6-2.0-1.91.8-1.70.7-0.32.00.8-3.6-1.82.3
Pavlov. Cond. lever latency0.40.51.90.40.50.70.8-0.80.5-0.10.0-0.8-0.51.40.7-0.9
Pavlov. Cond. magazine entry latency1.82.14.5-1.3-1.6-2.0-2.12.1-1.4-2.0-1.2-1.1-0.9-0.80.8-0.2
Pavlov. Cond. change in total contacts0.40.61.4-0.7-0.9-1.0-1.11.2-0.8-0.7-0.7-0.1-0.1-0.90.10.4
Pavlov. Cond. index score0.60.82.0-0.8-1.0-1.2-1.41.4-1.0-0.8-0.7-0.1-0.1-1.00.10.4
Pavlov. Cond. latency score0.30.51.2-0.5-0.7-0.9-1.11.1-0.7-0.8-0.5-0.1-0.1-0.70.10.3
Pavlov. Cond. lever contacts0.30.41.4-0.4-0.5-0.6-0.80.8-0.5-0.0-0.10.60.4-1.2-0.50.8
Pavlov. Cond. magazine entry number1.72.14.21.41.61.92.1-2.01.41.91.31.31.00.7-1.00.2
Pavlov. Cond. intertrial magazine entries0.30.41.30.00.20.70.9-0.90.30.4-0.2-0.0-0.51.10.5-1.1
Pavlov. Cond. lever-magazine prob. diff.0.81.02.5-0.9-1.2-1.4-1.51.6-1.1-1.0-0.8-0.2-0.2-1.00.20.4
Pavlov. Cond. response bias1.11.53.3-1.2-1.4-1.6-1.81.8-1.3-0.6-0.80.50.0-1.8-0.30.8
Time in closed arm before self-admin0.20.31.2-0.5-0.5-0.4-0.30.3-0.20.30.10.40.6-1.1-0.60.9
Time in closed arm after self-admin0.10.10.4-0.6-0.7-0.4-0.30.4-0.2-0.1-0.0-0.10.3-0.5-0.20.4
Time in open arm before self-admin1.41.53.01.71.61.01.3-1.21.41.21.31.01.30.3-1.00.8
Time in open arm after self-admin0.40.51.31.11.00.90.8-0.80.90.40.70.10.40.6-0.2-0.1
Bone: periosteal estimation2.34.89.03.02.92.62.4-2.42.71.92.70.72.00.5-1.51.2
Bone: periosteal perimeter2.95.08.52.92.92.62.5-2.42.72.22.60.82.20.4-1.61.4
Bone: post-yield work0.00.10.3-0.10.00.20.2-0.2-0.00.60.00.50.3-0.2-0.20.1
Progressive ratio test 1 active lever presses0.40.51.6-0.5-0.7-0.4-0.40.4-0.5-1.0-0.6-1.3-0.70.51.0-0.7
Progressive ratio test 1 breakpoint0.40.51.6-0.5-0.8-0.4-0.50.5-0.4-1.0-0.6-1.3-0.80.41.0-0.7
Progressive ratio test 1 inactive lever presses2.23.110.0-1.4-1.8-1.1-1.21.2-0.4-2.7-1.5-3.2-1.60.92.4-1.7
Progressive ratio test 2 active lever presses0.40.51.01.00.80.90.9-0.90.80.30.7-0.20.30.7-0.1-0.1
Progressive ratio test 2 breakpoint0.40.41.01.00.70.90.9-0.90.80.30.7-0.20.30.7-0.1-0.1
Progressive ratio test 2 inactive lever presses0.20.41.41.00.40.40.4-0.41.2-0.30.8-0.90.60.20.00.3
Incentive Sensitization - Responses1.62.23.71.91.81.61.7-1.61.71.51.81.11.4-0.2-1.41.0
Incentive Sensitization - Breakpoint1.51.93.21.81.61.41.5-1.51.51.41.61.01.3-0.2-1.41.0
Sum of active levers in priming session hrs 5-60.10.10.50.10.30.30.2-0.30.0-0.20.1-0.6-0.20.70.5-0.3
Progressive ratio0.91.35.4-0.7-0.7-1.3-1.11.0-0.90.50.11.10.9-2.3-1.31.6
Food seeking constrained by brief footshock0.80.92.9-0.3-0.00.50.4-0.2-0.4-0.6-0.7-0.9-1.61.71.3-1.7
Seeking ratio, punishment vs. effort1.92.710.11.21.52.42.0-1.91.00.3-0.0-0.4-1.03.21.2-2.1
Retroperitoneal fat weight0.62.74.2-1.7-1.5-1.0-1.11.3-1.6-1.9-1.8-1.8-2.01.52.0-1.7
Reaction time number correct0.40.72.10.60.81.31.4-1.20.81.00.30.50.10.7-0.2-0.4
Reaction time mean minus median0.41.11.9-1.2-1.0-0.8-0.60.8-1.0-1.3-0.9-1.4-1.20.71.3-0.9
Reaction time mean minus median AUC0.92.24.6-1.6-1.5-1.2-1.01.1-1.3-1.9-1.3-2.1-1.70.91.8-1.4
Reaction time num false alarms0.60.91.6-1.0-0.8-0.5-0.90.8-0.9-1.1-1.0-1.2-1.10.51.2-1.1
Reaction time num false alarms AUC0.60.92.2-0.7-0.4-0.0-0.50.3-0.7-0.9-1.0-1.2-1.21.21.5-1.5
Reaction time trials correct on left0.40.72.10.60.81.31.4-1.20.81.00.30.50.10.7-0.2-0.4
Reaction time trials on left0.40.72.10.60.81.31.4-1.20.71.00.20.50.10.8-0.1-0.5
Reaction time mean1.52.44.8-1.6-1.8-2.0-1.71.8-1.2-2.2-1.2-2.0-1.4-0.31.3-0.6
Reaction time mean AUC1.62.54.8-1.6-1.8-2.0-1.81.8-1.3-2.2-1.3-2.0-1.5-0.21.4-0.6
Median of all reaction times1.92.75.2-1.6-2.0-2.3-2.02.0-1.1-2.3-1.2-2.0-1.3-0.81.2-0.3
Reaction time omissions0.40.61.3-0.6-0.5-0.3-0.20.2-0.7-0.7-0.9-0.7-1.00.81.1-1.1
Reaction time false alarm rate0.91.22.1-1.0-0.9-0.8-1.31.0-1.0-1.5-1.0-1.4-1.20.61.4-1.0
Reaction time premature initiation rate0.20.20.70.00.20.50.7-0.80.00.6-0.30.8-0.30.50.1-0.6
Reaction time premature initiations0.40.72.00.40.61.11.4-1.30.51.10.11.00.00.6-0.1-0.5
Std. dev. reaction times1.22.33.9-1.7-1.7-1.5-1.41.5-1.4-2.0-1.4-1.8-1.50.31.6-0.9
Reaction time trials completed0.40.72.10.60.81.31.4-1.20.71.00.20.50.10.8-0.1-0.5
Reaction time trials AUC0.30.51.70.50.71.21.3-1.00.60.90.10.50.00.7-0.1-0.5
Run reversals in cocaine runway, females0.20.20.90.20.20.3-0.00.00.2-0.4-0.2-0.6-0.50.90.6-0.6
Run reversals in cocaine runway, males0.60.61.6-1.0-0.6-0.1-0.00.1-1.3-0.2-1.1-0.4-1.20.60.9-1.1
Latency to leave start box in cocaine runway0.70.82.20.91.41.51.1-1.10.40.90.60.90.60.9-0.40.3
Latency to leave start box in cocaine runway, F0.30.31.5-0.20.20.50.4-0.4-0.4-0.1-0.6-0.1-0.41.20.8-0.8
Latency to leave start box in cocaine runway, M4.34.07.82.42.82.62.0-2.11.82.12.11.71.70.4-1.81.4
Std. dev. time between licks in bursts0.30.41.90.0-0.0-0.1-0.10.1-0.20.9-0.31.40.6-1.0-0.80.6
Total sessions with >9 infusions1.31.65.1-0.7-1.1-0.4-0.40.4-0.6-1.6-1.1-2.3-1.31.11.9-1.6
Short access day 1 total inactive lever presses0.60.72.41.20.70.70.6-0.61.5-0.50.7-1.60.50.60.5-0.3
Short access day 10 total inactive lever presses0.10.20.80.0-0.10.1-0.30.30.5-0.8-0.3-0.9-0.20.20.6-0.3
Short access day 1 total infusions0.20.31.70.40.00.40.1-0.10.2-0.70.0-1.3-0.10.80.8-0.5
Short access day 10 total infusions0.91.23.3-0.8-1.2-1.1-1.11.1-0.7-1.7-0.7-1.8-0.8-0.11.1-0.5
Short access total infusions1.01.34.1-0.7-1.2-0.8-0.80.8-0.6-1.6-0.9-2.0-1.00.51.5-1.0
Short access day 1 locomotion0.00.10.20.40.20.10.0-0.00.10.10.3-0.00.5-0.2-0.20.4
Short access day 10 total locomotion0.20.42.20.40.20.1-0.00.00.6-1.0-0.0-1.5-0.30.90.9-0.6
Short access total locomotion0.30.31.9-0.0-0.4-0.2-0.40.50.0-1.0-0.2-1.4-0.10.20.8-0.2
One hour access (0.3 mA shock)1.61.94.22.01.71.11.4-1.41.80.91.80.31.50.3-1.01.1
Compulsive drug intake1.01.22.91.61.51.01.5-1.51.70.51.0-0.30.50.9-0.1-0.2
One hour access (shock baseline)0.10.10.70.20.0-0.1-0.30.30.00.00.40.20.7-0.3-0.40.9
Social response proportion1.82.14.41.51.20.80.8-0.91.31.61.81.12.1-1.2-1.81.8
Social responses0.10.10.30.10.20.30.4-0.30.20.50.40.40.3-0.3-0.30.2
Social time0.30.41.20.50.50.70.7-0.50.6-0.10.4-0.9-0.21.10.5-0.7
Soleus weight8.825.843.65.46.26.56.6-6.64.36.44.35.03.82.7-3.61.5
Bone: stiffness0.61.02.01.11.11.31.4-1.31.00.50.6-0.50.11.40.4-0.7
Tibialis anterior weight8.428.653.06.36.77.17.2-7.35.35.94.53.93.53.5-2.90.7
Time to tail flick, vehicle, before self-admin2.42.56.6-2.6-2.0-1.8-1.71.6-2.5-0.6-1.90.3-1.2-0.70.6-0.4
Time to tail flick, vehicle, after self-admin0.20.20.80.90.60.20.1-0.20.90.10.6-0.20.5-0.2-0.20.2
Time to tail flick, test, before self-admin1.51.66.3-0.8-0.9-1.4-1.31.4-0.80.2-0.11.01.0-2.5-1.11.8
Time to tail flick, test, after self-admin1.51.52.5-1.4-1.5-1.5-1.51.5-1.1-1.6-1.1-1.4-0.9-0.21.1-0.3
Delta time to tail flick, vehicle, before/after SA0.90.83.11.71.10.80.6-0.51.8-0.11.1-0.70.70.3-0.10.2
Delta time to tail flick, test, before/after SA0.70.72.40.90.80.80.6-0.71.1-0.60.5-1.2-0.31.50.7-0.7
Tibia length1.13.15.62.31.70.70.8-0.82.11.32.41.02.3-1.6-2.12.4
Ambulatory time before self-admin0.20.30.8-0.4-0.4-0.5-0.70.7-0.5-0.9-0.5-0.8-0.40.10.7-0.2
Ambulatory time after self-admin1.61.94.82.21.81.51.7-1.62.20.41.4-0.60.51.30.0-0.4
Bone: tissue strength0.30.30.8-0.4-0.6-0.8-0.70.8-0.1-0.8-0.1-0.9-0.3-0.60.30.0
Total heroin consumption0.20.30.70.10.40.10.7-0.8-0.60.6-0.20.6-0.20.70.2-0.5
Bone: trabecular number0.81.32.5-1.6-1.6-1.3-1.41.3-1.5-0.7-1.3-0.3-0.8-0.90.5-0.1
Bone: trabecular spacing0.00.00.10.00.10.00.0-0.0-0.1-0.20.1-0.3-0.10.30.1-0.1
Bone: trabecular thickness0.40.61.61.10.90.70.7-0.61.30.31.0-0.30.80.2-0.40.5
Bone: trabecular tissue density7.310.719.94.54.13.93.9-3.94.22.83.61.03.11.7-1.81.2
Water consumed over 24 hours0.10.10.20.30.2-0.3-0.20.20.3-0.50.3-0.3-0.1-0.3-0.10.1
Number of responses in last shaping day0.10.10.20.30.10.40.3-0.30.30.20.2-0.00.4-0.0-0.10.2