Hub : Genes

Nedd4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Nedd4 0.24 0.13 1.2e-05 0.04 0.07 0.09 0.08 4.7e-03 8.1e-05 1.4e-05 6.4e-05
2 PL mRNA stability Nedd4 0.1 0.05 7.7e-09 0.07 0.08 0.08 0.07 1.5e-08 8.9e-09 7.0e-09 1.4e-08
3 pVTA mRNA stability Nedd4 0.07 0.05 3.1e-05 0.06 0.04 0.05 0.05 1.3e-05 1.5e-04 4.6e-05 5.6e-05
4 NAcc mRNA stability Nedd4 0.05 0.03 9.7e-07 0.04 0.04 0.04 0.04 2.3e-07 8.1e-07 7.6e-07 9.6e-07
5 OFC alternative TSS XM_039080889.1 0.22 0.13 9.0e-03 0.09 0.01 -0 0.04 3.6e-03 1.8e-01 4.2e-01 4.4e-02
6 Brain mRNA stability Nedd4 0.19 0.09 5.4e-09 0.09 0.1 0.11 0.1 1.8e-08 1.5e-09 3.7e-10 8.6e-10
7 Brain gene expression Nedd4 0.1 0.07 3.8e-08 0.07 0.09 0.08 0.08 4.8e-07 1.0e-08 6.8e-08 8.6e-08
8 Adipose mRNA stability Nedd4 0.24 0.11 2.0e-14 0.1 0.11 0.1 0.1 1.4e-11 1.3e-12 1.7e-11 1.3e-11
9 NAcc gene expression Nedd4 0.05 0.03 2.3e-06 0.04 0.04 0.03 0.04 3.2e-07 3.7e-07 5.1e-06 6.6e-07
10 Adipose gene expression Nedd4 0.45 0.14 1.1e-16 0.14 0.13 0.12 0.14 5.6e-15 2.1e-14 4.0e-13 4.8e-15
11 Brain alternative TSS XM_063264950.1 0.03 0.02 2.4e-03 0.03 0.02 0.02 0.02 6.0e-04 2.9e-03 4.8e-03 2.7e-03
12 Liver gene expression Nedd4 0.07 0.05 9.1e-07 0.04 0.04 0.03 0.04 1.3e-05 1.1e-05 1.2e-04 8.5e-05
13 Adipose isoform ratio XM_039080889.1 0.04 0.03 2.2e-03 0 0 0 0 1.2e-01 7.5e-02 7.5e-02 1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.30.50.50.40.5-0.50.5-0.0-0.4-0.10.00.6-0.1-0.3
Area under the delay curve0.30.51.3-0.3-0.2-0.0-0.2-0.1-0.40.70.8-0.80.81.1-1.1-1.2
BMI with tail5.017.528.1-4.1-4.9-5.0-5.15.1-3.45.34.3-4.23.5-1.1-3.8-2.4
BMI without tail0.52.96.0-1.3-1.9-2.3-2.42.4-0.72.51.4-2.00.8-1.1-1.3-0.4
Body weight3.816.626.0-4.4-4.5-4.2-4.24.1-3.45.14.1-4.64.3-0.2-4.2-3.2
Weight adjusted by age1.23.58.0-2.1-2.6-2.8-2.42.6-1.51.71.4-1.00.7-2.2-0.60.2
Bone surface0.00.10.2-0.3-0.3-0.4-0.40.5-0.10.40.1-0.20.1-0.2-0.10.1
Bone volume0.10.20.5-0.4-0.5-0.5-0.50.5-0.30.70.4-0.50.60.1-0.5-0.4
Breakpoint value in progressive ratio session0.10.10.30.50.20.4-0.10.20.50.3-0.0-0.50.20.0-0.2-0.4
Number of licking bursts1.23.55.42.01.91.91.9-1.91.8-2.3-2.11.7-2.2-0.31.91.8
Context. condit. distance diff. score0.30.31.3-0.1-0.00.10.0-0.0-0.70.40.6-0.40.71.2-0.8-0.9
Locomotion velocity, session 10.91.04.4-0.7-1.0-1.2-1.21.2-0.40.10.00.3-0.6-2.10.71.2
Locomotion distance, session 10.70.91.91.00.70.70.5-0.50.8-1.1-0.81.2-1.4-0.81.11.1
Locomotion velocity, session 20.10.11.00.50.30.20.3-0.21.00.1-0.4-0.0-0.3-0.30.30.0
Locomotion distance, session 20.30.51.81.10.50.20.2-0.11.3-0.1-0.70.2-1.0-0.80.60.7
Locomotion velocity, session 32.02.34.21.81.30.50.6-0.51.7-1.3-1.51.8-2.0-1.62.01.8
Locomotion distance, session 33.13.55.82.42.21.92.0-2.02.3-2.0-2.01.5-2.0-0.01.61.3
Stereotopy head waving bouts, day 30.80.92.1-1.3-1.3-1.2-1.21.2-1.50.51.00.00.6-0.8-0.2-0.1
Stereotopy head waving duration, day 31.51.93.8-1.8-1.8-1.8-1.71.7-2.01.01.4-0.11.0-1.0-0.4-0.3
Locomotion velocity, session 70.70.81.21.01.11.11.1-1.10.9-1.0-0.51.1-0.60.50.60.3
Locomotion distance, session 71.92.54.12.01.81.61.5-1.51.8-1.7-1.61.5-1.7-0.01.51.2
Stereotopy head waving bouts, day 70.40.41.7-0.3-0.6-1.1-0.90.9-0.20.40.20.0-0.3-1.30.20.7
Stereotopy head waving duration, day 70.50.62.7-0.3-0.5-1.1-0.90.9-0.20.2-0.00.5-0.5-1.70.71.0
Locomotion velocity, session 80.20.20.70.20.1-0.2-0.30.30.50.1-0.50.2-0.5-0.90.70.7
Locomotion distance, session 80.71.03.01.71.31.00.9-0.91.5-0.6-1.20.2-1.10.30.70.5
Degree of sensitization distance0.00.00.10.20.20.20.1-0.10.1-0.2-0.10.4-0.20.10.30.2
Degree of sensitization stereotypy0.30.31.5-0.1-0.4-0.9-0.70.70.00.30.00.0-0.4-1.20.30.7
Conditioned locomotion1.51.85.0-0.9-0.8-0.4-0.40.4-0.71.41.8-1.21.81.5-2.0-2.2
Cocaine response after cond. corrected2.94.47.5-2.6-2.7-2.7-2.72.7-2.61.82.2-0.71.4-1.5-0.9-0.2
Cocaine response after cond. not corrected2.43.56.2-2.4-2.4-2.3-2.42.4-2.51.52.0-0.61.3-1.2-0.9-0.2
Cocaine response before conditioning0.50.61.41.01.01.21.2-1.10.9-0.5-0.6-0.2-0.31.0-0.1-0.3
Saline control response0.40.61.9-0.0-0.1-0.3-0.30.3-0.2-0.7-0.31.4-0.8-1.31.11.1
Bone: connectivity density1.82.84.62.22.01.51.7-1.62.1-1.6-2.11.3-1.9-0.11.61.2
Bone: cortical apparent density0.50.81.70.90.91.01.1-1.10.5-1.3-0.70.9-0.80.10.80.5
Bone: cortical area2.03.27.0-2.6-2.2-1.6-1.51.4-2.61.02.60.22.10.3-1.3-1.5
Bone: cortical porosity0.40.41.60.10.50.90.8-0.80.1-0.20.20.30.51.3-0.4-0.9
Bone: cortical porosity0.80.94.00.20.71.21.1-1.10.30.00.2-0.10.82.0-0.7-1.4
Bone: cortical thickness0.40.72.0-1.0-0.60.00.0-0.1-1.4-0.31.41.11.00.7-0.5-1.0
Bone: cortical thickness0.30.41.1-0.8-0.5-0.0-0.10.1-1.1-0.11.00.80.90.4-0.3-0.8
Bone: cortical tissue density0.60.91.81.11.01.11.1-1.10.7-1.4-0.80.9-0.90.10.80.5
Condit. Reinf. active minus inactive responses1.31.53.31.41.31.41.4-1.41.70.1-0.9-1.4-0.11.8-0.7-0.9
Condit. Reinf. active-inactive response ratio0.90.93.7-0.3-0.00.60.6-0.6-0.40.30.6-1.01.11.9-1.3-1.6
Condit. Reinf. active responses1.52.06.12.21.81.41.3-1.32.5-0.1-1.7-1.0-1.10.80.20.3
Condit. Reinf. inactive responses2.73.58.12.72.00.90.8-0.82.8-0.8-2.40.6-2.5-1.41.92.3
Incentive salience index mean1.21.54.31.21.11.21.2-1.11.40.6-0.4-1.70.32.1-1.1-1.3
Condit. Reinf. lever presses0.71.03.31.10.91.00.9-0.91.10.6-0.2-1.20.31.8-1.0-1.1
Condit. Reinf. active minus inactive responses1.11.73.7-1.4-1.4-1.4-1.51.5-1.01.90.6-1.91.2-0.4-1.0-0.5
Condit. Reinf. active-inactive response ratio1.62.64.7-2.2-2.0-1.6-1.71.6-1.81.71.5-1.41.8-0.2-1.3-1.0
Condit. Reinf. active responses0.91.34.9-0.8-1.0-0.9-1.01.0-0.51.80.4-2.21.10.3-1.3-0.8
Condit. Reinf. inactive responses0.71.02.31.51.31.01.1-1.01.5-0.1-1.3-0.9-0.70.9-0.00.2
Condit. Reinf. lever presses0.30.41.0-0.6-0.20.10.2-0.2-0.90.20.6-0.31.01.0-0.6-0.9
Condit. Reinf. lever reinforcers received0.91.24.2-0.8-0.9-0.8-0.80.9-0.61.70.6-2.11.30.5-1.3-1.0
Conditioned reinforcement - actives0.00.10.2-0.2-0.1-0.2-0.40.4-0.40.00.30.30.4-0.40.1-0.2
Conditioned reinforcement - inactives0.10.31.0-0.5-0.2-0.6-0.70.7-1.0-0.20.50.80.2-0.60.20.2
Conditioned locomotion0.40.62.0-0.10.20.40.2-0.2-0.30.50.7-0.61.11.4-1.0-1.4
Patch foraging indifference point 0 sec0.10.21.1-0.2-0.4-0.5-0.10.20.3-0.20.00.3-0.5-1.10.60.6
Patch foraging indifference point AUC1.22.87.32.52.31.91.7-1.72.7-0.7-2.2-0.6-1.50.80.50.5
Delay disc. indifference point, 0s delay1.31.53.21.81.71.51.3-1.81.7-0.6-1.2-0.3-0.61.10.1-0.3
Delay disc. indifference point, 16s delay0.81.23.2-0.7-0.50.00.1-0.2-0.90.81.3-0.91.41.8-1.6-1.8
Delay disc. indifference point, 2s delay0.10.10.20.10.30.2-0.1-0.4-0.1-0.4-0.20.4-0.20.10.20.1
Delay disc. indifference point, 24s delay0.10.10.60.00.20.30.2-0.3-0.10.20.3-0.10.40.8-0.5-0.6
Delay disc. indifference point, 4s delay0.60.62.50.40.60.70.5-0.70.10.40.3-0.80.71.6-1.0-1.2
Delay disc. indifference point, 8s delay0.20.30.9-0.1-0.3-0.3-0.50.3-0.20.80.5-1.00.30.5-0.9-0.6
Indifference point function ln k1.23.78.6-2.8-2.7-2.2-2.22.1-2.91.12.20.01.5-1.2-0.8-0.5
Indifference point function log k1.23.78.6-2.8-2.7-2.2-2.22.1-2.91.12.20.01.5-1.2-0.8-0.5
Patch foraging total patch changes 0 sec0.10.31.3-0.4-0.6-0.7-0.30.40.0-0.20.20.4-0.4-1.20.50.6
Patch foraging total patch changes 12 sec0.91.22.71.41.31.01.0-0.91.6-0.8-1.20.6-1.30.10.90.9
Patch foraging total patch changes 18 sec0.10.20.50.30.20.30.4-0.30.7-0.6-0.40.3-0.7-0.30.40.3
Patch foraging total patch changes 24 sec0.51.83.61.41.10.70.9-0.71.8-1.2-1.60.8-1.9-1.21.61.8
Patch foraging total patch changes 6 sec1.01.65.21.71.30.80.9-0.92.3-0.6-1.7-0.2-1.7-0.50.91.2
Patch foraging time to switch 0 sec0.10.52.20.50.91.01.0-0.90.2-0.20.10.50.41.5-0.2-0.6
Patch foraging water rate 0 sec0.51.73.8-1.6-1.9-1.9-1.81.8-1.30.90.9-0.60.5-1.5-0.30.2
Patch foraging water rate 12 sec0.93.48.0-2.0-2.4-2.7-2.62.5-1.71.00.7-0.50.0-2.80.31.3
Patch foraging water rate 18 sec0.30.71.5-1.1-1.2-1.2-1.01.0-1.10.30.4-0.10.1-1.00.10.4
Patch foraging water rate 24 sec0.60.93.20.40.30.1-0.1-0.00.4-1.0-1.30.8-1.5-1.11.31.8
Patch foraging water rate 6 sec0.40.62.4-0.8-1.0-1.0-1.01.0-0.60.1-0.1-0.1-0.3-1.50.30.9
Seeking ratio, delayed vs. immediate footshock0.40.61.2-0.8-1.1-0.8-1.01.0-0.41.00.6-1.10.5-0.3-0.6-0.3
Distance traveled before self-admin0.00.00.1-0.2-0.10.00.0-0.00.0-0.20.00.3-0.0-0.20.20.0
Distance traveled after self-admin1.12.04.0-1.9-1.8-1.7-1.81.8-2.00.71.50.40.4-1.5-0.10.5
Extensor digitorum longus weight4.819.131.2-4.7-5.1-5.5-5.65.6-3.65.63.8-4.43.5-1.7-3.3-1.9
Bone: elastic displacement0.10.20.9-0.2-0.3-0.1-0.20.2-0.10.50.1-1.00.40.3-0.6-0.5
Bone: elastic work0.60.82.0-0.7-0.5-0.1-0.0-0.0-0.60.90.7-1.21.31.2-1.3-1.4
Bone: endosteal estimation1.43.35.8-2.2-2.4-2.4-2.22.3-1.92.01.8-1.21.4-0.8-1.2-0.6
Bone: endosteal perimeter2.66.49.4-2.9-3.0-3.0-2.82.8-2.53.12.5-2.22.4-0.1-2.2-1.7
Epididymis fat weight0.10.71.71.31.20.40.4-0.61.2-0.3-1.00.3-0.8-0.30.80.7
Delta time in closed arm before/after self-admin0.10.10.4-0.10.20.50.3-0.3-0.2-0.10.30.00.40.6-0.3-0.5
Delta time in open arm before/after self-admin0.81.02.20.70.80.40.6-0.60.7-1.2-1.11.4-1.1-0.81.51.3
Diff in mean of infusions in LGA sessions1.01.85.0-0.2-0.4-0.3-0.70.8-0.51.91.1-2.21.71.5-1.9-1.7
Delay discount exponential model param0.30.41.00.30.30.10.30.00.4-0.6-0.70.7-0.7-0.91.01.0
Extinction: sum of active levers before priming0.30.41.40.30.1-0.10.1-0.00.6-0.6-0.50.8-0.6-1.21.00.7
Active lever presses in extinction session 60.20.20.6-0.3-0.4-0.2-0.70.8-0.20.60.2-0.50.5-0.5-0.2-0.2
Bone: final force1.32.23.6-1.9-1.7-1.3-1.31.2-1.91.51.9-0.71.80.5-1.4-1.4
Bone: final moment1.52.34.2-2.0-1.7-1.2-1.21.1-2.11.42.1-0.51.90.7-1.5-1.6
Food consumed during 24 hour testing period0.81.63.8-1.9-2.0-1.5-1.51.5-1.70.20.90.20.2-1.60.20.5
Glucose0.30.52.40.1-0.3-0.6-0.60.6-0.0-0.2-0.40.4-0.9-1.60.81.2
Heart weight0.50.85.2-0.0-0.3-0.6-0.60.60.41.5-0.0-2.30.50.6-1.1-0.6
Delay discount hyperbolic model param0.30.41.20.20.2-0.00.20.20.4-0.6-0.70.7-0.7-1.01.01.1
Intermittent access intake day 1-15 change0.10.51.30.10.3-0.3-0.50.6-0.5-0.5-0.21.1-0.7-1.00.91.1
Intermittent access intake escalation0.10.30.7-0.20.0-0.5-0.80.8-0.8-0.00.20.7-0.3-0.70.50.8
Intermittent access intake escalation 20.40.71.9-1.1-1.0-0.9-1.11.1-1.40.61.1-0.00.5-0.5-0.4-0.1
Intermitt. access day 1 inactive lever presses0.00.21.0-0.00.30.20.3-0.3-1.0-0.40.40.60.20.6-0.1-0.3
Intermitt. access day 15 inactive lever presses0.10.61.2-0.9-0.7-0.7-1.01.0-1.10.80.8-0.51.0-0.2-0.6-0.5
Intermitt. access escalation Index0.20.61.8-0.6-1.0-0.8-0.0-0.00.30.80.5-1.30.60.4-1.0-1.1
Intermittent access day 1 total infusions0.20.62.40.30.80.90.7-0.80.1-1.4-0.41.6-0.60.10.90.4
Intermittent access day 15 total infusions0.20.41.50.40.90.70.4-0.4-0.1-0.9-0.31.2-0.40.10.70.4
Intermittent access terminal intake (last 3 days)0.10.20.6-0.20.30.40.1-0.0-0.7-0.40.40.80.30.5-0.0-0.3
Intermittent access total infusions0.40.42.4-0.00.50.30.2-0.2-0.3-1.1-0.11.6-0.4-0.50.90.5
Intermittent access day 1 locomotion0.61.12.40.81.31.21.2-1.30.5-1.5-0.81.6-0.60.60.90.3
Intermittent access day 15 total locomotion0.10.30.9-0.60.10.20.2-0.2-0.9-0.50.60.80.60.5-0.1-0.5
Intermittent access total locomotion0.10.10.5-0.4-0.2-0.3-0.30.2-0.7-0.30.20.60.3-0.30.30.0
Intermittent access standard deviation0.10.41.3-0.8-0.4-0.4-0.60.6-1.1-0.40.71.20.1-0.90.30.2
Left kidney weight0.97.212.5-3.4-3.5-3.5-3.53.4-3.22.62.4-1.51.8-2.0-1.4-0.4
Right kidney weight0.63.98.7-2.0-2.4-3.0-2.82.7-1.81.91.1-1.40.6-2.5-0.50.5
Cocaine induced anxiety0.20.41.50.30.20.50.5-0.50.40.30.4-0.50.71.1-0.8-1.2
Post-drug Anxiety2.42.84.82.22.12.11.9-1.91.9-1.7-1.71.2-1.60.41.20.7
Baseline Anxiety2.94.88.42.22.01.41.6-1.42.1-2.4-2.81.9-2.9-1.52.82.7
Tail length0.52.55.01.61.81.51.5-1.51.8-1.7-2.21.0-1.5-0.71.81.4
Length with tail0.10.31.0-1.0-0.6-0.5-0.40.3-0.40.50.0-0.70.8-0.6-0.2-0.3
Length without tail2.010.415.7-4.0-3.8-3.2-3.02.9-3.23.63.2-3.43.8-0.2-3.2-2.8
Times rat made contact with spout0.20.20.6-0.4-0.5-0.1-0.10.2-0.5-0.60.30.8-0.5-0.50.20.5
Lifetime Intake0.30.42.10.10.50.20.2-0.2-0.1-1.0-0.21.4-0.4-0.50.90.5
Liver weight, left1.42.45.0-1.5-1.9-2.2-2.22.2-1.11.50.8-1.60.4-1.8-0.60.4
Liver weight, right0.61.02.7-0.7-0.9-1.5-1.61.6-0.91.20.6-0.80.3-1.0-0.30.4
Locomotor activity4.26.611.1-3.3-3.3-3.2-2.92.8-2.62.82.7-1.82.4-1.0-1.9-1.4
Locomotor testing distance2.04.98.9-2.9-3.0-2.9-2.62.6-2.42.12.1-1.21.7-1.5-1.3-0.6
Locomotor testing rearing0.20.81.6-1.0-1.1-1.2-1.21.2-0.81.10.3-1.00.3-0.9-0.40.2
Locomotion in novel chamber0.20.20.8-0.6-0.20.0-0.00.1-0.9-0.10.90.40.70.2-0.4-0.6
Locomotion in novel chamber post-restriction0.10.41.80.60.70.80.6-0.70.40.1-0.2-0.50.21.4-0.4-0.4
Fecal boli incidents, locomotor time 10.10.41.10.60.40.70.7-0.70.8-0.2-0.2-0.20.01.1-0.3-0.9
Change in fecal boli incidents, locomotor task1.71.84.9-1.9-1.6-1.6-1.41.6-2.20.21.30.70.6-1.70.10.4
Time >=10cm from walls, locomotor time 10.70.81.3-0.6-0.8-0.6-0.61.1-0.71.01.1-0.81.10.6-1.1-1.0
Bouts of movement, locomotor time 10.00.10.10.2-0.3-0.1-0.10.10.30.20.2-0.4-0.2-0.3-0.3-0.2
Total resting periods, locomotor time 10.00.00.20.1-0.3-0.0-0.00.00.3-0.00.2-0.2-0.3-0.4-0.1-0.1
Rest time, locomotor task time 10.30.52.5-0.5-0.6-0.10.5-0.1-0.30.11.1-0.30.90.6-1.0-1.6
Distance moved, locomotor task time 10.30.81.71.21.20.60.4-0.81.1-0.5-1.30.5-0.7-0.21.01.0
Vertical activity count, locomotor time 10.00.30.70.50.60.70.3-0.80.7-0.1-0.8-0.4-0.10.50.20.2
Time >=10cm from walls, locomotor time 20.10.21.0-0.3-0.6-0.5-0.10.3-0.30.30.7-0.30.70.0-0.6-1.0
Bouts of movement, locomotor time 20.10.20.80.3-0.3-0.6-0.30.40.50.3-0.3-0.3-0.8-0.90.30.7
Total resting periods, locomotor time 20.10.31.10.3-0.3-0.7-0.40.50.50.2-0.3-0.2-1.0-1.10.40.9
Rest time, locomotor task time 20.10.10.3-0.3-0.10.30.5-0.0-0.3-0.50.50.6-0.30.3-0.0-0.2
Distance moved, locomotor task time 20.60.82.01.10.90.30.4-0.71.3-0.4-1.40.5-0.7-0.81.11.0
Vertical activity count, locomotor time 20.41.02.00.90.90.90.8-1.41.1-1.2-1.41.0-0.7-0.41.30.7
Light reinforcement 10.73.27.1-1.5-1.9-1.8-1.81.8-1.02.51.7-2.71.60.2-2.1-1.4
Light reinforcement 20.20.51.5-1.1-0.70.1-0.00.1-1.2-0.41.10.60.70.2-0.4-0.8
Bone: marrow area1.53.76.4-2.4-2.5-2.5-2.32.4-2.02.01.9-1.21.5-0.7-1.2-0.7
Bone: maximum diameter3.46.912.7-3.6-3.5-3.1-3.02.9-3.22.33.2-0.92.5-0.6-1.8-1.4
Bone: maximum force1.12.33.7-1.8-1.7-1.4-1.21.2-1.81.61.9-0.91.90.7-1.5-1.5
Bone: maximum moment1.32.54.3-2.0-1.7-1.3-1.21.1-2.01.52.1-0.72.10.8-1.6-1.6
Mean time between licks in bursts0.00.30.80.10.40.90.8-0.80.1-0.7-0.60.3-0.10.50.2-0.1
Mean num. licks in bursts1.43.65.8-2.4-2.4-2.1-2.02.1-2.31.82.4-0.91.9-0.3-1.6-1.4
Cd content in liver1.21.33.51.41.51.51.4-1.51.9-0.4-1.1-0.5-0.31.2-0.1-0.4
Co content in liver1.01.23.80.40.61.11.1-1.20.70.20.3-1.20.91.9-1.3-1.8
Cu content in liver0.30.41.0-0.2-0.2-0.1-0.10.1-0.30.80.7-0.80.90.7-1.0-1.0
Fe content in liver0.30.41.20.0-0.3-0.5-0.50.50.1-0.3-0.20.8-1.0-1.10.81.0
K content in liver0.50.51.3-0.6-0.6-0.8-0.90.8-0.31.20.3-1.00.6-0.3-0.5-0.2
Mg content in liver0.40.51.4-0.6-0.6-0.7-0.80.7-0.31.10.3-1.20.7-0.2-0.7-0.2
Mn content in liver2.32.65.3-2.2-1.7-1.1-1.21.1-2.31.22.2-0.52.10.6-1.5-1.7
Na content in liver1.51.73.5-1.2-1.7-1.8-1.91.9-0.71.60.9-1.20.4-1.2-0.6-0.0
Rb content in liver0.40.41.3-0.4-0.5-0.9-1.01.0-0.20.60.20.1-0.2-1.10.30.6
Se content in liver0.40.51.40.10.20.10.1-0.10.1-0.8-0.51.2-0.8-1.11.11.0
Sr content in liver0.70.61.50.90.91.01.0-1.11.2-0.6-1.0-0.1-0.50.60.4-0.1
Zn content in liver0.60.72.6-0.2-0.2-0.00.1-0.1-0.01.10.4-1.61.11.0-1.3-1.1
Bone: minimum diameter1.63.05.7-2.0-1.7-1.0-0.80.8-1.91.52.4-0.92.31.6-2.1-2.3
Time in familiar zone, hab. session 10.40.41.1-0.3-0.30.1-0.20.1-0.20.70.8-0.80.90.9-1.0-1.0
Time in novel zone, hab. session 10.20.31.10.20.2-0.00.2-0.2-0.1-0.7-0.41.0-0.5-0.60.80.6
Total zone transitions, hab. session 11.31.83.41.71.20.80.8-0.81.7-1.4-1.41.2-1.9-1.11.51.5
Total locomotion distance, hab. session 10.91.32.71.41.10.50.5-0.51.5-0.9-1.40.7-1.6-1.11.21.5
Locomotion velocity, hab. session 10.60.92.01.10.70.20.2-0.21.1-0.7-1.10.5-1.4-1.21.01.4
Time in familiar zone, hab. session 20.40.50.90.60.60.50.3-0.30.5-0.8-0.70.7-0.9-0.70.90.9
Time in novel zone, hab. session 20.80.91.6-1.2-1.2-0.8-0.70.7-1.20.61.3-0.21.10.4-0.9-0.9
Total zone transitions, hab. session 20.60.72.71.40.90.50.5-0.51.70.2-1.1-1.0-0.90.1-0.00.4
Total locomotion distance, hab. session 20.40.51.81.10.60.20.3-0.31.30.5-0.8-1.3-0.60.4-0.40.1
Locomotion velocity, hab. session 20.30.41.41.00.50.30.3-0.31.10.5-0.6-1.2-0.40.5-0.5-0.0
Novel to familiar place preference ratio1.11.42.6-1.0-1.1-1.1-1.01.0-0.81.61.2-1.41.40.7-1.4-1.3
Novelty place preference1.31.73.1-1.2-1.3-1.2-1.11.1-1.01.71.4-1.51.60.7-1.5-1.5
Time in novel zone, NPP test1.72.13.1-1.5-1.6-1.4-1.31.4-1.31.81.6-1.41.60.4-1.5-1.4
Total zone transitions, NPP test0.20.41.20.90.30.20.1-0.11.1-0.1-0.7-0.4-1.0-0.60.20.6
Total locomotion distance, NPP test0.40.61.81.00.4-0.0-0.00.01.1-0.2-1.0-0.1-1.3-0.90.71.2
Locomotion velocity, NPP test0.91.33.01.61.00.50.5-0.51.7-0.6-1.50.2-1.7-0.91.11.5
Intraocular pressure0.00.10.30.10.20.30.4-0.20.5-0.1-0.5-0.2-0.2-0.00.20.2
Delta distance traveled before/after self-admin2.32.66.1-2.1-1.9-1.9-2.22.1-2.51.11.5-0.10.6-1.5-0.40.5
Delta ambulatory time before/after self-admin1.52.67.2-2.3-1.8-1.8-2.02.0-2.71.11.80.00.9-1.1-0.50.3
Parametrial fat weight1.43.25.01.92.02.02.1-2.22.0-2.2-2.01.6-1.7-0.11.60.9
Pavlov. Cond. lever latency0.81.13.5-1.5-1.2-1.0-1.01.0-1.9-0.30.91.00.4-1.00.40.4
Pavlov. Cond. magazine entry latency3.64.616.51.92.02.42.3-2.21.90.6-0.5-2.00.94.1-1.9-2.6
Pavlov. Cond. change in total contacts1.41.55.11.21.11.21.1-1.11.20.6-0.2-1.40.52.3-1.3-1.5
Pavlov. Cond. index score2.73.57.42.32.22.32.3-2.22.5-0.1-1.2-1.1-0.22.7-0.8-1.3
Pavlov. Cond. latency score2.32.96.02.32.12.12.1-2.02.4-0.1-1.3-1.0-0.42.3-0.6-1.0
Pavlov. Cond. lever contacts1.11.32.91.41.21.31.2-1.21.70.4-0.6-1.2-0.01.7-0.8-1.0
Pavlov. Cond. magazine entry number3.24.014.2-1.9-2.0-2.4-2.32.2-1.9-0.30.71.6-0.6-3.81.62.2
Pavlov. Cond. intertrial magazine entries1.72.15.81.30.90.10.1-0.11.2-1.1-1.71.0-2.0-2.01.92.4
Pavlov. Cond. lever-magazine prob. diff.2.73.37.32.22.12.22.2-2.12.40.1-1.2-1.4-0.12.7-0.9-1.4
Pavlov. Cond. response bias2.83.512.81.61.62.01.9-1.81.70.7-0.3-2.00.83.6-1.8-2.3
Pavlov. Cond. lever latency0.40.51.9-0.4-0.5-0.7-0.80.8-0.5-0.10.00.8-0.5-1.40.70.9
Pavlov. Cond. magazine entry latency1.52.14.51.31.62.02.1-2.11.4-2.0-1.21.1-0.90.80.80.2
Pavlov. Cond. change in total contacts0.20.61.40.70.91.01.1-1.20.8-0.7-0.70.1-0.10.90.1-0.4
Pavlov. Cond. index score0.50.82.00.81.01.21.4-1.41.0-0.8-0.70.1-0.11.00.1-0.4
Pavlov. Cond. latency score0.30.51.20.50.70.91.1-1.10.7-0.8-0.50.1-0.10.70.1-0.3
Pavlov. Cond. lever contacts0.30.41.40.40.50.60.8-0.80.5-0.0-0.1-0.60.41.2-0.5-0.8
Pavlov. Cond. magazine entry number1.62.14.2-1.4-1.6-1.9-2.12.0-1.41.91.3-1.31.0-0.7-1.0-0.2
Pavlov. Cond. intertrial magazine entries0.20.41.3-0.0-0.2-0.7-0.90.9-0.30.4-0.20.0-0.5-1.10.51.1
Pavlov. Cond. lever-magazine prob. diff.0.71.02.50.91.21.41.5-1.61.1-1.0-0.80.2-0.21.00.2-0.4
Pavlov. Cond. response bias1.11.53.31.21.41.61.8-1.81.3-0.6-0.8-0.50.01.8-0.3-0.8
Time in closed arm before self-admin0.20.31.20.50.50.40.3-0.30.20.30.1-0.40.61.1-0.6-0.9
Time in closed arm after self-admin0.10.10.40.60.70.40.3-0.40.2-0.1-0.00.10.30.5-0.2-0.4
Time in open arm before self-admin1.21.53.0-1.7-1.6-1.0-1.31.2-1.41.21.3-1.01.3-0.3-1.0-0.8
Time in open arm after self-admin0.40.51.3-1.1-1.0-0.9-0.80.8-0.80.40.7-0.10.4-0.6-0.20.1
Bone: periosteal estimation2.04.89.0-3.0-2.9-2.6-2.42.4-2.71.92.7-0.72.0-0.5-1.5-1.2
Bone: periosteal perimeter2.55.08.6-2.9-2.9-2.6-2.52.4-2.72.22.6-0.82.2-0.4-1.6-1.4
Bone: post-yield work0.00.10.30.1-0.0-0.2-0.20.20.00.60.0-0.50.30.2-0.2-0.1
Progressive ratio test 1 active lever presses0.30.51.60.50.70.40.4-0.40.5-1.0-0.61.3-0.7-0.51.00.7
Progressive ratio test 1 breakpoint0.30.51.60.50.80.40.5-0.50.4-1.0-0.61.3-0.8-0.41.00.7
Progressive ratio test 1 inactive lever presses1.23.110.01.41.81.11.2-1.20.4-2.7-1.53.2-1.6-0.92.41.7
Progressive ratio test 2 active lever presses0.30.51.0-1.0-0.8-0.9-0.90.9-0.80.30.70.20.3-0.7-0.10.1
Progressive ratio test 2 breakpoint0.40.41.0-1.0-0.7-0.9-0.90.9-0.80.30.70.20.3-0.7-0.10.1
Progressive ratio test 2 inactive lever presses0.10.41.3-1.0-0.4-0.4-0.40.4-1.2-0.30.80.90.6-0.20.0-0.3
Incentive Sensitization - Responses0.82.23.7-1.9-1.8-1.6-1.71.6-1.71.51.8-1.11.40.2-1.4-1.0
Incentive Sensitization - Breakpoint0.81.93.2-1.8-1.6-1.4-1.51.5-1.51.41.6-1.01.30.2-1.4-1.0
Sum of active levers in priming session hrs 5-60.10.10.5-0.1-0.3-0.3-0.20.3-0.0-0.20.10.6-0.2-0.70.50.3
Progressive ratio0.51.35.40.70.71.31.1-1.00.90.50.1-1.10.92.3-1.3-1.6
Food seeking constrained by brief footshock0.80.92.90.30.0-0.5-0.40.20.4-0.6-0.70.9-1.6-1.71.31.7
Seeking ratio, punishment vs. effort1.22.710.1-1.2-1.5-2.4-2.01.9-1.00.3-0.00.4-1.0-3.21.22.1
Retroperitoneal fat weight0.62.74.21.71.51.01.1-1.31.6-1.9-1.81.8-2.0-1.52.01.7
Reaction time number correct0.20.72.1-0.6-0.8-1.3-1.41.2-0.81.00.3-0.50.1-0.7-0.20.4
Reaction time mean minus median0.21.11.91.21.00.80.6-0.81.0-1.3-0.91.4-1.2-0.71.30.9
Reaction time mean minus median AUC0.32.24.61.61.51.21.0-1.11.3-1.9-1.32.1-1.7-0.91.81.4
Reaction time num false alarms0.50.91.61.00.80.50.9-0.80.9-1.1-1.01.2-1.1-0.51.21.1
Reaction time num false alarms AUC0.40.92.20.70.40.00.5-0.30.7-0.9-1.01.2-1.2-1.21.51.5
Reaction time trials correct on left0.20.72.1-0.6-0.8-1.3-1.41.2-0.81.00.3-0.50.1-0.7-0.20.4
Reaction time trials on left0.20.72.1-0.6-0.8-1.3-1.41.2-0.71.00.2-0.50.1-0.8-0.10.5
Reaction time mean1.12.44.81.61.82.01.7-1.81.2-2.2-1.22.0-1.40.31.30.6
Reaction time mean AUC1.12.54.81.61.82.01.8-1.81.3-2.2-1.32.0-1.50.21.40.6
Median of all reaction times1.72.75.21.62.02.32.0-2.01.1-2.3-1.22.0-1.30.81.20.3
Reaction time omissions0.30.61.30.60.50.30.2-0.20.7-0.7-0.90.7-1.0-0.81.11.1
Reaction time false alarm rate0.91.22.11.00.90.81.3-1.01.1-1.5-1.01.4-1.2-0.61.41.0
Reaction time premature initiation rate0.20.20.7-0.0-0.2-0.5-0.70.8-0.00.6-0.3-0.8-0.3-0.50.10.6
Reaction time premature initiations0.20.72.0-0.4-0.6-1.1-1.41.3-0.51.10.1-1.00.0-0.6-0.10.5
Std. dev. reaction times0.72.33.91.71.71.51.4-1.51.4-2.0-1.41.8-1.5-0.31.60.9
Reaction time trials completed0.20.72.1-0.6-0.8-1.3-1.41.2-0.71.00.2-0.50.1-0.8-0.10.5
Reaction time trials AUC0.20.51.7-0.5-0.7-1.2-1.31.0-0.60.90.1-0.50.0-0.7-0.10.5
Run reversals in cocaine runway, females0.20.20.9-0.2-0.2-0.30.0-0.0-0.2-0.4-0.20.6-0.5-0.90.60.6
Run reversals in cocaine runway, males0.60.61.61.00.60.10.0-0.11.3-0.2-1.10.4-1.2-0.60.91.1
Latency to leave start box in cocaine runway0.60.82.2-0.9-1.4-1.5-1.11.1-0.40.90.6-0.90.6-0.9-0.4-0.3
Latency to leave start box in cocaine runway, F0.20.31.50.2-0.2-0.5-0.40.40.4-0.1-0.60.1-0.4-1.20.80.8
Latency to leave start box in cocaine runway, M4.24.07.8-2.4-2.8-2.6-2.02.1-1.82.12.1-1.71.7-0.4-1.8-1.4
Std. dev. time between licks in bursts0.20.41.9-0.00.00.10.1-0.10.10.9-0.3-1.40.61.0-0.8-0.6
Total sessions with >9 infusions1.31.65.10.71.10.40.4-0.40.6-1.6-1.12.3-1.3-1.11.91.6
Short access day 1 total inactive lever presses0.40.72.4-1.2-0.7-0.7-0.60.6-1.5-0.50.71.60.5-0.60.50.3
Short access day 10 total inactive lever presses0.00.20.8-0.00.1-0.10.3-0.3-0.5-0.8-0.30.9-0.2-0.20.60.3
Short access day 1 total infusions0.20.31.7-0.4-0.0-0.4-0.10.1-0.2-0.70.01.3-0.1-0.80.80.5
Short access day 10 total infusions0.71.23.30.81.21.11.1-1.10.7-1.7-0.71.8-0.80.11.10.5
Short access total infusions0.91.34.10.71.20.80.8-0.80.6-1.6-0.92.0-1.0-0.51.51.0
Short access day 1 locomotion0.00.10.2-0.4-0.2-0.1-0.00.0-0.10.10.30.00.50.2-0.2-0.4
Short access day 10 total locomotion0.10.42.2-0.4-0.2-0.10.0-0.0-0.6-1.0-0.01.5-0.3-0.90.90.6
Short access total locomotion0.20.31.90.00.40.20.4-0.5-0.0-1.0-0.21.4-0.1-0.20.80.2
One hour access (0.3 mA shock)1.61.94.2-2.0-1.7-1.1-1.41.4-1.80.91.8-0.31.5-0.3-1.0-1.1
Compulsive drug intake0.81.22.9-1.6-1.5-1.0-1.51.5-1.70.51.00.30.5-0.9-0.10.2
One hour access (shock baseline)0.10.10.7-0.2-0.00.10.3-0.3-0.00.00.4-0.20.70.3-0.4-0.9
Social response proportion1.62.14.4-1.5-1.2-0.8-0.80.9-1.31.61.8-1.12.11.2-1.8-1.8
Social responses0.10.10.3-0.1-0.2-0.3-0.40.3-0.20.50.4-0.40.30.3-0.3-0.2
Social time0.20.41.2-0.5-0.5-0.7-0.70.5-0.6-0.10.40.9-0.2-1.10.50.7
Soleus weight8.825.843.6-5.4-6.2-6.5-6.66.6-4.46.44.3-5.03.8-2.7-3.6-1.5
Bone: stiffness0.51.02.0-1.1-1.1-1.3-1.41.3-1.00.50.60.50.1-1.40.40.7
Tibialis anterior weight8.328.653.0-6.3-6.7-7.1-7.27.3-5.35.94.5-3.93.5-3.5-2.9-0.7
Time to tail flick, vehicle, before self-admin2.02.56.62.62.01.81.7-1.62.5-0.6-1.9-0.3-1.30.70.60.4
Time to tail flick, vehicle, after self-admin0.10.20.8-0.9-0.6-0.2-0.10.2-0.90.10.60.20.50.2-0.2-0.2
Time to tail flick, test, before self-admin1.41.66.30.80.91.41.3-1.40.80.2-0.1-1.00.92.5-1.1-1.8
Time to tail flick, test, after self-admin1.51.52.51.41.51.51.5-1.51.1-1.6-1.11.4-0.90.21.10.3
Delta time to tail flick, vehicle, before/after SA0.80.83.1-1.7-1.1-0.8-0.60.5-1.8-0.11.10.70.7-0.3-0.1-0.2
Delta time to tail flick, test, before/after SA0.60.72.4-0.9-0.8-0.8-0.60.7-1.1-0.60.51.2-0.3-1.50.70.7
Tibia length1.13.15.6-2.3-1.7-0.7-0.80.8-2.11.32.4-1.02.31.6-2.1-2.4
Ambulatory time before self-admin0.10.30.80.40.40.50.7-0.70.5-0.9-0.50.8-0.4-0.10.70.2
Ambulatory time after self-admin1.21.94.8-2.2-1.8-1.5-1.71.6-2.20.41.40.60.5-1.30.00.4
Bone: tissue strength0.30.30.80.40.60.80.7-0.80.1-0.8-0.10.9-0.30.60.3-0.0
Total heroin consumption0.20.30.7-0.1-0.4-0.1-0.70.80.60.6-0.2-0.6-0.2-0.70.20.5
Bone: trabecular number0.71.32.51.61.61.31.4-1.31.5-0.7-1.30.3-0.80.90.50.1
Bone: trabecular spacing0.00.00.1-0.0-0.1-0.0-0.00.00.1-0.20.10.3-0.1-0.30.10.1
Bone: trabecular thickness0.40.61.6-1.1-0.9-0.7-0.70.6-1.30.31.00.30.8-0.2-0.4-0.5
Bone: trabecular tissue density6.110.719.9-4.5-4.1-3.9-3.93.9-4.22.83.6-1.03.2-1.7-1.8-1.2
Water consumed over 24 hours0.00.10.2-0.3-0.20.30.2-0.2-0.3-0.50.30.3-0.10.3-0.1-0.1
Number of responses in last shaping day0.00.10.2-0.3-0.1-0.4-0.30.3-0.30.20.20.00.40.0-0.1-0.2