Hub : Genes

Nedd4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Nedd4 0.11 0.05 7.4e-10 0.07 0.09 0.1 0.09 1.3e-08 7.2e-10 8.3e-11 2.4e-10
2 Brain mRNA stability Nedd4 0.17 0.08 1.8e-08 0.08 0.09 0.09 0.09 3.7e-08 7.7e-09 1.4e-08 2.4e-08
3 BLA mRNA stability Nedd4 0.17 0.11 1.5e-04 0.04 0.04 0.03 0.04 3.8e-03 3.2e-03 1.6e-02 2.2e-03
4 Brain gene expression Nedd4 0.09 0.06 2.6e-07 0.07 0.07 0.08 0.07 6.5e-07 1.8e-07 5.6e-08 1.8e-07
5 NAcc mRNA stability Nedd4 0.03 0.03 2.3e-03 0.03 0.01 0.01 0.01 3.5e-04 1.3e-02 1.9e-02 8.3e-03
6 PL isoform ratio XM_039080889.1 0.04 0.03 8.7e-04 0.03 0.02 0 0.03 1.8e-04 2.6e-03 1.7e-01 7.9e-04
7 Adipose mRNA stability Nedd4 0.28 0.12 7.2e-16 0.12 0.13 0.13 0.12 8.3e-13 7.3e-14 4.9e-14 1.4e-13
8 Adipose alternative polyA NM_012986.1 0.04 0.03 3.2e-05 0.03 0.04 0.03 0.03 1.5e-04 7.5e-05 1.6e-04 2.8e-04
9 Adipose alternative polyA XM_017595479.2 0.04 0.03 2.6e-05 0.03 0.04 0.03 0.03 1.5e-04 6.0e-05 1.6e-04 2.7e-04
10 NAcc gene expression Nedd4 0.07 0.04 3.9e-08 0.07 0.06 0.06 0.06 2.9e-08 8.0e-08 9.4e-08 5.4e-08
11 Adipose gene expression Nedd4 0.39 0.14 5.1e-15 0.12 0.11 0.11 0.12 1.2e-13 1.2e-12 1.4e-12 6.3e-13
12 Liver gene expression Nedd4 0.07 0.04 6.2e-07 0.04 0.04 0.04 0.04 4.1e-05 8.4e-06 6.6e-05 4.3e-05
13 Adipose alternative TSS XM_039080889.1 0.02 0.02 8.5e-03 0 0 -0 -0 2.9e-01 1.2e-01 6.4e-01 3.7e-01
14 Adipose alternative TSS NM_012986.1 0.02 0.02 9.4e-03 0 0 -0 0 2.9e-01 9.5e-02 8.8e-01 3.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.10.40.2-0.2-0.0-0.40.2-0.6-0.00.1-0.1-0.2-0.2-0.40.5-0.5
Area under the delay curve1.01.12.5-0.40.50.5-0.9-0.1-0.3-0.91.1-1.1-1.2-1.2-1.51.6-1.6
BMI with tail5.116.624.6-4.44.14.2-4.5-4.53.9-3.95.0-4.9-4.1-3.6-3.92.6-2.6
BMI without tail0.61.25.9-0.70.40.7-1.6-1.62.40.51.1-1.1-1.30.1-0.0-0.60.6
Body weight3.916.423.5-4.33.84.1-4.6-3.93.9-3.54.8-4.8-4.5-4.1-4.02.9-2.9
Weight adjusted by age2.32.69.4-2.31.71.9-1.7-2.03.1-1.01.6-1.6-1.3-0.8-0.6-0.20.3
Bone surface0.20.30.7-0.70.60.7-0.9-0.70.5-0.50.6-0.6-0.3-0.5-0.40.2-0.2
Bone volume0.40.71.1-0.90.91.0-1.1-0.80.3-0.90.9-0.9-0.5-0.8-0.80.6-0.6
Breakpoint value in progressive ratio session0.10.10.20.4-0.3-0.30.00.20.40.50.2-0.2-0.5-0.2-0.20.2-0.2
Number of licking bursts2.83.35.01.9-1.8-2.02.21.8-1.22.0-2.12.11.61.91.8-1.31.3
Context. condit. distance diff. score0.20.30.70.00.20.1-0.30.1-0.8-0.60.3-0.3-0.2-0.7-0.70.9-0.9
Locomotion velocity, session 10.60.72.9-0.80.80.6-0.0-1.11.7-0.20.1-0.10.30.60.7-1.21.2
Locomotion distance, session 10.70.92.20.8-0.7-1.01.20.5-0.50.6-1.01.01.11.51.1-1.01.0
Locomotion velocity, session 20.10.10.60.3-0.6-0.50.10.30.80.3-0.10.1-0.10.30.3-0.30.3
Locomotion distance, session 20.20.30.80.6-0.9-0.70.20.00.60.7-0.30.30.10.90.6-0.70.7
Locomotion velocity, session 31.92.24.31.4-1.2-1.11.30.4-0.41.1-1.61.61.71.82.0-2.12.1
Locomotion distance, session 32.93.25.02.2-2.1-2.12.11.9-1.61.8-1.91.91.51.71.6-1.01.0
Stereotopy head waving bouts, day 30.50.61.8-1.21.31.2-0.7-1.20.5-1.10.5-0.50.0-0.2-0.2-0.30.3
Stereotopy head waving duration, day 31.11.33.3-1.71.81.6-1.1-1.81.0-1.70.9-0.9-0.1-0.5-0.4-0.20.2
Locomotion velocity, session 70.80.81.71.1-0.9-1.01.31.0-1.10.4-1.01.01.10.80.7-0.40.4
Locomotion distance, session 72.02.53.61.9-1.7-1.71.81.4-1.21.5-1.81.81.61.61.6-1.21.2
Stereotopy head waving bouts, day 70.30.30.8-0.30.40.4-0.3-0.90.8-0.20.1-0.10.10.50.5-0.90.9
Stereotopy head waving duration, day 70.40.41.3-0.30.40.5-0.3-1.01.1-0.2-0.00.00.40.50.7-1.11.1
Locomotion velocity, session 80.20.30.80.2-0.3-0.2-0.3-0.30.80.6-0.20.20.10.40.7-0.90.9
Locomotion distance, session 80.60.92.41.4-1.6-1.40.60.9-0.51.3-0.80.80.30.90.7-0.40.4
Degree of sensitization distance0.00.00.20.2-0.1-0.10.20.1-0.1-0.0-0.30.30.50.10.2-0.20.2
Degree of sensitization stereotypy0.20.20.8-0.30.30.4-0.4-0.80.9-0.20.2-0.2-0.00.20.2-0.60.6
Conditioned locomotion1.61.93.8-1.00.80.8-1.2-0.4-0.0-1.81.5-1.5-1.2-1.5-1.92.0-2.0
Cocaine response after cond. corrected3.74.18.5-2.82.92.9-2.0-2.81.7-2.81.8-1.8-0.4-1.7-1.10.2-0.1
Cocaine response after cond. not corrected3.13.47.6-2.62.72.6-1.7-2.41.4-2.81.6-1.6-0.3-1.6-1.10.3-0.3
Cocaine response before conditioning0.40.51.51.0-1.0-1.10.71.2-0.80.7-0.40.4-0.10.2-0.10.6-0.6
Saline control response0.50.61.9-0.20.40.10.7-0.30.1-0.3-0.70.71.40.91.0-1.21.2
Bone: connectivity density1.52.43.51.9-1.9-1.71.31.5-1.41.8-1.71.71.21.71.5-1.11.1
Bone: cortical apparent density0.30.41.60.6-0.4-0.61.10.8-1.30.2-0.70.70.80.40.4-0.20.2
Bone: cortical area2.43.610.7-2.52.82.4-1.1-1.70.4-3.31.6-1.6-0.2-2.0-1.71.3-1.3
Bone: cortical porosity0.20.31.00.0-0.1-0.10.00.6-0.3-0.50.1-0.1-0.1-0.8-0.71.0-1.0
Bone: cortical porosity0.40.51.50.5-0.6-0.50.11.1-0.8-0.1-0.00.0-0.2-0.8-0.71.2-1.2
Bone: cortical thickness0.61.04.3-0.91.30.80.4-0.1-1.4-2.10.3-0.30.7-1.0-0.91.0-1.0
Bone: cortical thickness0.30.31.2-0.60.80.40.40.0-0.7-1.1-0.10.10.8-0.5-0.30.3-0.3
Bone: cortical tissue density0.40.51.60.7-0.5-0.71.10.8-1.30.3-0.70.70.70.40.5-0.30.3
Condit. Reinf. active minus inactive responses0.91.02.11.0-1.4-1.10.11.2-0.41.10.3-0.4-1.5-0.4-0.81.4-1.4
Condit. Reinf. active-inactive response ratio0.91.03.4-0.30.30.2-0.10.5-0.7-0.60.8-0.8-1.0-1.2-1.51.8-1.9
Condit. Reinf. active responses1.01.34.61.7-2.1-1.70.31.20.12.1-0.20.2-1.10.60.20.3-0.3
Condit. Reinf. inactive responses2.83.47.82.2-2.6-2.10.90.80.62.8-1.41.40.52.32.0-2.02.0
Incentive salience index mean1.01.23.20.7-1.2-0.9-0.31.00.10.70.7-0.8-1.7-0.7-1.21.8-1.8
Condit. Reinf. lever presses0.60.82.10.8-1.1-0.8-0.30.90.30.40.6-0.6-1.2-0.6-1.01.5-1.5
Condit. Reinf. active minus inactive responses2.12.65.9-1.61.21.7-2.4-1.71.9-0.81.8-1.8-2.0-1.4-1.30.8-0.8
Condit. Reinf. active-inactive response ratio2.72.94.6-2.02.02.1-2.0-1.81.3-1.81.8-1.8-1.4-1.7-1.51.0-0.9
Condit. Reinf. active responses1.62.25.3-1.20.81.3-2.2-1.21.4-0.51.8-1.8-2.3-1.4-1.51.2-1.2
Condit. Reinf. inactive responses0.60.72.41.2-1.5-1.1-0.10.9-0.31.6-0.10.1-0.90.3-0.10.4-0.5
Condit. Reinf. lever presses0.20.20.6-0.30.50.30.00.1-0.7-0.80.2-0.2-0.1-0.4-0.60.7-0.7
Condit. Reinf. lever reinforcers received1.62.24.7-1.20.81.3-2.1-1.11.1-0.71.7-1.8-2.2-1.5-1.61.4-1.4
Conditioned reinforcement - actives0.20.20.40.3-0.3-0.30.20.1-0.10.3-0.40.40.50.60.5-0.60.6
Conditioned reinforcement - inactives0.10.10.5-0.10.50.50.1-0.4-0.3-0.5-0.20.20.70.10.3-0.50.5
Conditioned locomotion0.70.82.40.10.00.1-0.40.5-0.8-0.50.7-0.7-0.9-1.3-1.31.6-1.6
Patch foraging indifference point 0 sec0.20.20.6-0.30.30.00.6-0.20.8-0.4-0.20.20.70.30.5-0.70.7
Patch foraging indifference point AUC1.61.85.62.1-2.4-2.00.81.6-0.62.3-0.80.8-0.51.00.6-0.00.0
Delay disc. indifference point, 0s delay0.70.82.21.4-1.5-1.30.51.2-0.91.2-0.40.3-0.40.4-0.00.5-0.5
Delay disc. indifference point, 16s delay1.21.22.9-0.70.70.6-0.6-0.0-0.7-1.31.0-1.0-0.8-1.5-1.51.7-1.7
Delay disc. indifference point, 2s delay0.10.10.60.3-0.1-0.20.20.2-0.80.2-0.30.30.30.20.1-0.10.1
Delay disc. indifference point, 24s delay0.10.10.30.10.0-0.1-0.20.3-0.5-0.30.2-0.2-0.2-0.4-0.50.6-0.6
Delay disc. indifference point, 4s delay0.50.51.70.4-0.2-0.2-0.60.6-0.9-0.10.5-0.5-0.9-0.6-1.01.3-1.3
Delay disc. indifference point, 8s delay0.60.61.3-0.30.30.4-1.0-0.50.2-0.41.0-1.0-1.1-0.6-1.00.9-0.9
Indifference point function ln k1.52.16.0-2.42.42.1-0.8-1.81.3-2.01.1-1.00.1-0.7-0.6-0.10.1
Indifference point function log k1.52.16.0-2.42.42.1-0.8-1.81.3-2.01.1-1.00.1-0.7-0.6-0.10.1
Patch foraging total patch changes 0 sec0.20.30.9-0.60.60.30.5-0.41.0-0.7-0.00.00.70.20.4-0.70.7
Patch foraging total patch changes 12 sec0.50.61.61.3-1.1-1.10.90.9-0.60.9-0.70.70.40.50.6-0.30.3
Patch foraging total patch changes 18 sec0.00.00.2-0.00.0-0.20.50.10.3-0.0-0.10.10.10.20.2-0.10.1
Patch foraging total patch changes 24 sec1.01.22.21.3-1.2-1.21.20.70.01.5-1.01.00.61.31.3-1.21.2
Patch foraging total patch changes 6 sec0.40.61.81.2-1.4-1.20.60.60.21.3-0.50.5-0.10.70.7-0.50.5
Patch foraging time to switch 0 sec0.30.42.11.0-0.7-0.50.20.9-1.50.1-0.60.50.5-0.3-0.00.4-0.4
Patch foraging water rate 0 sec1.21.95.1-2.11.91.7-1.1-1.82.3-1.41.3-1.3-0.7-0.5-0.5-0.10.1
Patch foraging water rate 12 sec1.42.26.1-2.01.92.0-1.2-2.32.5-1.00.9-0.9-0.2-0.00.3-1.31.3
Patch foraging water rate 18 sec0.30.30.9-0.90.90.8-0.2-0.81.0-0.60.4-0.4-0.0-0.00.0-0.40.4
Patch foraging water rate 24 sec0.71.02.60.5-0.5-0.70.90.50.21.2-1.01.00.61.61.2-1.31.3
Patch foraging water rate 6 sec0.30.41.6-0.90.80.7-0.2-0.81.30.10.3-0.3-0.30.40.3-0.70.7
Seeking ratio, delayed vs. immediate footshock0.50.51.5-0.90.50.8-1.2-1.01.2-0.30.8-0.8-0.6-0.3-0.40.0-0.0
Distance traveled before self-admin0.10.10.2-0.10.30.4-0.3-0.10.4-0.50.3-0.3-0.2-0.5-0.30.3-0.3
Distance traveled after self-admin1.71.94.8-1.82.22.0-1.1-2.01.7-1.90.9-0.90.2-0.8-0.4-0.30.3
Extensor digitorum longus weight4.718.533.0-4.84.14.7-5.7-5.45.4-3.14.9-4.9-4.5-3.5-3.21.6-1.6
Bone: elastic displacement0.10.10.6-0.30.20.2-0.4-0.20.20.20.4-0.5-0.8-0.2-0.40.4-0.4
Bone: elastic work0.60.81.8-0.60.40.5-0.9-0.10.2-0.40.9-1.0-1.3-1.0-1.21.3-1.3
Bone: endosteal estimation1.83.88.6-2.52.22.3-2.1-2.42.9-1.92.1-2.0-1.3-1.4-1.30.5-0.5
Bone: endosteal perimeter3.87.811.5-3.22.83.2-3.4-3.03.1-2.73.1-3.1-2.5-2.6-2.41.6-1.6
Epididymis fat weight0.41.01.81.2-1.3-1.10.90.8-0.11.3-1.01.00.71.01.2-1.11.1
Delta time in closed arm before/after self-admin0.50.51.1-0.91.10.8-0.4-0.40.3-0.90.8-0.8-0.6-0.6-0.80.6-0.6
Delta time in open arm before/after self-admin2.72.64.01.6-1.5-1.21.41.0-1.31.4-2.02.01.81.71.9-1.71.7
Diff in mean of infusions in LGA sessions1.11.22.7-0.20.20.2-1.4-0.60.8-0.11.3-1.3-1.6-1.2-1.41.4-1.4
Delay discount exponential model param0.80.92.00.4-0.5-0.50.80.10.20.8-1.11.11.11.11.3-1.41.4
Extinction: sum of active levers before priming1.51.53.60.8-0.7-1.01.91.0-0.50.8-1.41.41.51.21.4-1.31.3
Active lever presses in extinction session 60.20.20.50.4-0.4-0.40.30.20.10.7-0.40.40.30.30.5-0.50.5
Bone: final force1.93.15.1-2.02.02.0-1.8-1.61.3-2.31.8-1.8-1.1-1.9-1.81.4-1.4
Bone: final moment2.03.26.2-2.12.12.0-1.7-1.51.0-2.51.8-1.8-1.0-1.9-1.91.5-1.5
Food consumed during 24 hour testing period1.01.23.8-1.92.01.4-0.3-1.51.3-1.30.5-0.50.3-0.10.0-0.60.6
Glucose0.20.30.9-0.60.70.5-0.3-0.81.00.10.2-0.2-0.20.30.3-0.70.7
Heart weight1.52.14.5-1.00.71.2-2.1-0.91.1-0.71.7-1.7-1.9-1.8-1.71.5-1.5
Delay discount hyperbolic model param0.60.61.50.3-0.4-0.40.60.00.40.7-0.80.80.80.91.1-1.21.2
Intermittent access intake day 1-15 change2.32.34.51.1-0.8-0.81.30.2-0.51.0-1.61.72.01.92.0-2.12.1
Intermittent access intake escalation2.72.64.71.4-0.9-1.01.60.4-0.71.2-1.81.82.12.02.1-2.22.2
Intermittent access intake escalation 20.50.51.40.10.1-0.00.8-0.20.10.1-0.60.61.20.90.9-1.11.1
Intermitt. access day 1 inactive lever presses0.30.31.2-0.10.90.30.80.0-1.1-0.7-0.30.30.9-0.10.1-0.10.1
Intermitt. access day 15 inactive lever presses0.40.51.1-0.10.30.3-0.6-0.0-0.3-0.30.7-0.7-0.8-1.0-1.01.1-1.1
Intermitt. access escalation Index2.01.82.7-1.60.91.2-1.3-0.61.5-1.11.5-1.5-1.6-1.5-1.41.2-1.2
Intermittent access day 1 total infusions0.30.31.2-0.20.60.20.70.3-1.0-0.6-0.50.51.10.00.3-0.30.3
Intermittent access day 15 total infusions1.51.64.40.9-0.4-0.61.50.6-1.30.3-1.61.62.11.21.5-1.41.4
Intermittent access terminal intake (last 3 days)0.40.41.70.30.0-0.20.80.4-1.3-0.3-0.80.81.30.30.5-0.40.4
Intermittent access total infusions1.31.54.80.30.3-0.11.60.3-1.0-0.2-1.41.42.21.11.4-1.51.5
Intermittent access day 1 locomotion0.60.62.10.6-0.4-0.51.01.0-1.50.2-1.01.01.20.40.6-0.40.3
Intermittent access day 15 total locomotion0.30.31.1-0.20.60.50.60.4-1.1-0.8-0.30.30.8-0.5-0.10.1-0.1
Intermittent access total locomotion0.20.20.7-0.30.50.40.60.0-0.2-0.4-0.40.40.80.10.5-0.60.6
Intermittent access standard deviation0.91.03.20.6-0.0-0.31.60.4-1.00.1-1.11.21.80.81.1-1.01.0
Left kidney weight2.36.410.8-3.33.03.1-2.8-3.12.8-2.42.7-2.7-1.9-2.3-1.91.0-1.0
Right kidney weight1.23.24.9-1.81.51.8-2.2-1.92.2-1.12.2-2.2-2.2-1.8-1.61.1-1.1
Cocaine induced anxiety0.30.41.01.0-1.0-1.00.60.8-0.80.6-0.20.2-0.10.1-0.10.4-0.4
Post-drug Anxiety3.13.47.72.7-2.8-2.71.62.0-1.72.5-1.71.60.71.51.2-0.50.5
Baseline Anxiety1.51.63.61.6-1.7-1.40.91.1-0.61.9-1.31.30.61.31.3-1.01.0
Tail length1.13.48.41.7-2.0-1.71.21.30.42.9-1.91.90.92.12.3-2.22.1
Length with tail0.31.12.6-1.20.91.1-1.3-0.81.6-0.31.1-1.1-1.5-1.2-0.80.6-0.6
Length without tail5.912.919.5-4.04.03.8-3.2-2.81.8-4.43.9-3.9-2.9-4.2-3.93.3-3.3
Times rat made contact with spout0.20.20.6-0.40.6-0.00.8-0.2-0.3-0.7-0.20.20.60.70.2-0.30.3
Lifetime Intake1.21.34.10.50.1-0.31.50.4-1.1-0.0-1.41.42.01.01.3-1.41.4
Liver weight, left0.40.61.6-0.70.60.4-0.3-1.01.20.20.0-0.00.01.00.7-1.31.3
Liver weight, right0.50.83.3-0.70.50.6-1.2-1.41.80.20.7-0.7-0.90.20.1-0.70.7
Locomotor activity4.36.911.6-3.43.23.2-3.1-2.92.8-3.02.8-2.7-1.9-2.2-1.91.0-1.0
Locomotor testing distance2.64.38.3-2.92.82.7-2.4-2.52.0-2.52.1-2.1-1.2-1.6-1.40.5-0.5
Locomotor testing rearing0.50.72.5-1.00.81.0-1.6-1.01.0-0.30.9-0.9-1.1-0.4-0.40.0-0.0
Locomotion in novel chamber0.30.31.4-0.00.50.10.90.2-1.2-0.7-0.40.40.9-0.10.00.1-0.1
Locomotion in novel chamber post-restriction0.20.20.40.5-0.5-0.4-0.20.6-0.40.50.0-0.1-0.5-0.2-0.30.5-0.6
Fecal boli incidents, locomotor time 10.30.30.80.0-0.5-0.30.30.7-0.3-0.10.2-0.3-0.5-0.6-0.60.9-0.9
Change in fecal boli incidents, locomotor task1.81.76.3-1.92.51.9-0.6-1.91.0-1.80.7-0.70.4-0.3-0.2-0.50.5
Time >=10cm from walls, locomotor time 11.01.01.4-0.90.90.9-1.1-1.00.5-1.01.1-1.1-0.7-1.2-1.21.0-1.0
Bouts of movement, locomotor time 10.10.10.5-0.40.1-0.00.10.00.7-0.10.4-0.4-0.4-0.0-0.20.2-0.2
Total resting periods, locomotor time 10.00.10.4-0.30.1-0.00.30.10.6-0.10.2-0.2-0.10.1-0.10.1-0.1
Rest time, locomotor task time 10.30.31.1-0.70.70.20.90.30.1-1.10.2-0.20.2-0.3-0.40.6-0.5
Distance moved, locomotor task time 10.70.81.81.2-1.2-0.7-0.00.3-0.71.4-0.90.90.50.71.0-0.90.9
Vertical activity count, locomotor time 10.20.20.80.6-0.9-0.4-0.60.4-0.60.9-0.20.2-0.3-0.10.2-0.00.0
Time >=10cm from walls, locomotor time 20.20.20.4-0.70.60.4-0.1-0.20.3-0.60.6-0.6-0.4-0.4-0.60.6-0.6
Bouts of movement, locomotor time 20.20.21.2-0.1-0.10.0-0.1-0.51.10.40.2-0.2-0.20.50.3-0.50.5
Total resting periods, locomotor time 20.20.21.5-0.1-0.10.00.1-0.51.20.40.1-0.1-0.10.60.4-0.60.6
Rest time, locomotor task time 20.20.21.3-0.30.5-0.11.10.3-0.5-0.4-0.20.20.50.1-0.00.2-0.2
Distance moved, locomotor task time 20.70.82.01.1-1.3-0.6-0.10.3-0.11.4-0.90.90.40.91.1-1.11.1
Vertical activity count, locomotor time 21.21.32.01.1-1.4-1.00.71.1-0.91.2-1.41.41.11.01.3-1.11.1
Light reinforcement 12.13.86.0-2.01.51.7-2.3-1.72.3-1.42.4-2.4-2.4-1.6-2.01.5-1.5
Light reinforcement 20.30.51.8-0.91.10.51.1-0.0-0.6-1.3-0.00.00.6-0.2-0.30.4-0.4
Bone: marrow area2.04.38.7-2.72.42.5-2.2-2.63.0-2.12.2-2.1-1.4-1.6-1.40.6-0.6
Bone: maximum diameter3.76.812.8-3.63.63.4-2.3-3.02.4-3.52.6-2.5-1.1-2.3-2.01.1-1.1
Bone: maximum force2.13.64.9-2.11.92.1-2.2-1.71.4-2.22.1-2.0-1.5-2.1-2.01.6-1.6
Bone: maximum moment2.23.86.3-2.22.12.1-2.1-1.61.2-2.52.0-2.0-1.3-2.2-2.11.7-1.7
Mean time between licks in bursts0.30.51.40.8-0.7-0.70.61.0-1.21.0-0.60.6-0.00.50.3-0.0-0.0
Mean num. licks in bursts2.63.17.1-2.32.42.1-1.6-2.01.1-2.71.8-1.8-1.0-1.2-1.51.0-1.0
Cd content in liver0.40.51.60.7-1.2-0.6-0.40.70.01.30.1-0.1-1.1-0.2-0.30.5-0.5
Co content in liver1.01.23.20.00.0-0.1-0.40.3-0.5-0.31.1-1.1-1.7-1.2-1.51.8-1.8
Cu content in liver1.01.22.6-0.50.30.7-1.6-0.50.6-0.41.3-1.3-1.6-1.4-1.31.3-1.3
Fe content in liver2.12.53.61.4-1.6-1.61.11.1-0.61.4-1.91.91.81.91.9-1.71.7
K content in liver1.01.02.1-0.90.81.0-1.4-1.01.2-0.61.1-1.1-1.2-1.2-0.90.5-0.5
Mg content in liver2.82.95.3-1.71.41.7-2.3-1.62.2-1.11.9-1.9-1.9-1.7-1.51.0-1.0
Mn content in liver1.92.24.2-1.61.91.6-1.1-1.00.5-2.11.4-1.4-0.8-2.0-1.61.4-1.4
Na content in liver0.60.62.9-1.00.80.7-0.9-1.11.7-0.70.7-0.7-0.2-0.3-0.2-0.20.2
Rb content in liver0.50.72.1-0.80.60.9-1.1-1.51.4-0.30.5-0.5-0.3-0.10.2-0.80.8
Se content in liver0.50.61.30.6-0.7-0.50.60.7-0.50.5-1.01.01.20.70.9-0.80.8
Sr content in liver0.30.31.00.7-0.9-0.80.30.9-0.31.0-0.20.2-0.50.20.00.3-0.3
Zn content in liver1.01.13.3-0.20.30.3-0.70.2-0.4-0.51.0-1.0-1.4-1.1-1.61.8-1.8
Bone: minimum diameter2.03.88.3-2.12.11.9-1.5-1.10.6-2.92.0-2.0-1.1-2.3-2.32.1-2.1
Time in familiar zone, hab. session 10.50.41.2-0.10.20.0-0.50.0-0.2-0.50.8-0.8-0.8-0.8-1.01.1-1.1
Time in novel zone, hab. session 10.40.41.00.0-0.10.10.40.1-0.20.1-0.80.81.00.50.8-0.90.9
Total zone transitions, hab. session 11.31.83.01.4-1.3-1.41.60.8-0.71.2-1.41.41.21.71.5-1.41.4
Total locomotion distance, hab. session 10.81.12.61.2-1.2-1.11.00.5-0.21.2-1.01.00.61.61.2-1.21.2
Locomotion velocity, hab. session 10.50.82.10.8-0.8-0.80.90.20.00.9-0.70.70.51.51.1-1.11.1
Time in familiar zone, hab. session 20.40.50.80.6-0.5-0.60.40.3-0.30.9-0.70.70.60.90.8-0.80.8
Time in novel zone, hab. session 20.70.72.5-1.01.21.0-0.4-0.70.1-1.60.7-0.7-0.1-1.0-0.80.7-0.7
Total zone transitions, hab. session 20.50.62.11.2-1.5-1.1-0.20.7-0.11.40.0-0.0-1.00.40.00.2-0.2
Total locomotion distance, hab. session 20.40.62.10.8-1.2-0.7-0.60.30.21.20.4-0.5-1.50.2-0.40.6-0.6
Locomotion velocity, hab. session 20.40.51.80.7-1.0-0.6-0.60.30.01.00.4-0.5-1.30.0-0.50.7-0.7
Novel to familiar place preference ratio1.51.53.1-1.20.81.1-1.8-0.90.9-1.01.4-1.4-1.4-1.5-1.31.1-1.1
Novelty place preference1.81.83.6-1.31.01.3-1.9-1.10.8-1.21.6-1.6-1.5-1.6-1.41.2-1.2
Time in novel zone, NPP test2.12.13.8-1.61.41.6-2.0-1.30.9-1.51.6-1.6-1.4-1.7-1.41.1-1.1
Total zone transitions, NPP test0.20.30.70.6-0.8-0.70.20.20.60.8-0.00.0-0.50.70.2-0.20.2
Total locomotion distance, NPP test0.30.41.20.6-0.9-0.70.10.00.71.1-0.30.3-0.21.00.6-0.70.7
Locomotion velocity, NPP test0.71.02.61.2-1.5-1.20.60.50.41.6-0.70.70.21.41.0-0.90.9
Intraocular pressure0.10.10.6-0.1-0.2-0.0-0.4-0.00.60.8-0.10.1-0.40.20.2-0.20.2
Delta distance traveled before/after self-admin1.81.95.2-2.02.21.9-1.1-2.31.6-1.60.9-0.80.2-0.3-0.1-0.70.7
Delta ambulatory time before/after self-admin1.71.95.6-2.02.42.0-1.1-2.11.1-1.80.8-0.80.3-0.6-0.3-0.40.4
Parametrial fat weight1.32.66.61.2-0.9-1.32.60.9-0.31.2-1.71.71.42.21.9-1.91.8
Pavlov. Cond. lever latency0.60.72.3-1.11.51.20.0-1.1-0.0-1.1-0.20.21.0-0.00.4-0.80.8
Pavlov. Cond. magazine entry latency2.93.810.91.6-2.0-1.6-0.72.2-1.10.80.9-1.0-2.4-1.6-2.23.3-3.3
Pavlov. Cond. change in total contacts1.11.23.30.9-1.1-0.9-0.41.0-0.40.50.7-0.7-1.5-0.7-1.31.8-1.8
Pavlov. Cond. index score1.72.25.82.0-2.4-2.00.22.2-0.91.5-0.0-0.0-1.3-0.3-0.91.8-1.8
Pavlov. Cond. latency score1.41.85.21.9-2.3-2.00.32.0-0.71.5-0.10.0-1.2-0.1-0.61.4-1.5
Pavlov. Cond. lever contacts0.70.82.11.1-1.4-1.1-0.11.3-0.30.90.3-0.3-1.1-0.3-0.71.2-1.2
Pavlov. Cond. magazine entry number2.32.87.3-1.82.11.70.2-2.21.3-0.9-0.40.51.71.11.6-2.72.7
Pavlov. Cond. intertrial magazine entries1.72.14.61.1-1.1-1.00.90.1-0.01.6-1.41.41.12.02.0-2.22.1
Pavlov. Cond. lever-magazine prob. diff.1.72.15.21.9-2.3-1.90.02.1-0.71.40.1-0.2-1.5-0.4-1.01.9-1.9
Pavlov. Cond. response bias2.12.57.21.3-1.7-1.3-0.61.8-0.90.70.8-0.8-2.0-1.3-1.82.7-2.7
Pavlov. Cond. lever latency0.30.40.9-0.70.70.6-0.2-1.00.9-0.2-0.00.00.50.20.5-0.90.9
Pavlov. Cond. magazine entry latency2.02.34.71.7-1.5-1.72.22.0-2.11.3-1.61.61.11.40.9-0.20.2
Pavlov. Cond. change in total contacts0.30.51.30.9-0.9-0.90.61.2-1.00.7-0.50.5-0.00.30.10.3-0.4
Pavlov. Cond. index score0.60.82.01.2-1.2-1.11.01.4-1.20.9-0.70.70.10.50.20.3-0.3
Pavlov. Cond. latency score0.40.41.20.8-0.7-0.80.91.1-1.00.6-0.60.60.20.40.20.2-0.2
Pavlov. Cond. lever contacts0.20.30.80.5-0.6-0.60.20.8-0.80.20.1-0.1-0.6-0.1-0.50.9-0.9
Pavlov. Cond. magazine entry number1.92.34.1-1.81.71.7-1.9-1.92.0-1.51.6-1.6-1.1-1.3-1.00.3-0.3
Pavlov. Cond. intertrial magazine entries0.30.41.2-0.70.80.8-0.5-1.10.9-0.50.2-0.20.3-0.10.2-0.70.7
Pavlov. Cond. lever-magazine prob. diff.0.70.92.41.3-1.2-1.21.11.6-1.31.0-0.80.80.20.50.20.3-0.4
Pavlov. Cond. response bias0.71.02.61.3-1.4-1.30.61.6-1.50.8-0.30.3-0.50.1-0.41.1-1.1
Time in closed arm before self-admin0.30.31.00.6-0.5-0.4-0.40.5-1.00.10.2-0.2-0.5-0.6-0.60.9-0.9
Time in closed arm after self-admin0.10.10.10.10.30.2-0.4-0.2-0.3-0.30.3-0.3-0.3-0.3-0.40.3-0.3
Time in open arm before self-admin1.61.73.9-1.91.91.6-0.9-1.62.0-1.51.2-1.2-0.6-0.9-0.70.1-0.1
Time in open arm after self-admin0.40.41.2-0.20.40.40.6-0.30.2-0.2-0.60.61.10.50.8-1.01.0
Bone: periosteal estimation2.65.49.9-3.13.02.9-2.1-2.72.5-3.12.4-2.3-1.1-2.1-1.81.0-1.0
Bone: periosteal perimeter2.74.57.2-2.72.52.7-2.2-2.42.2-2.52.2-2.2-1.3-2.0-1.71.0-0.9
Bone: post-yield work0.10.10.50.1-0.20.1-0.6-0.30.30.20.4-0.4-0.7-0.2-0.20.1-0.1
Progressive ratio test 1 active lever presses0.40.41.1-0.20.60.50.2-0.6-0.1-0.4-0.40.41.10.40.7-0.90.9
Progressive ratio test 1 breakpoint0.30.31.2-0.00.40.20.5-0.3-0.5-0.4-0.50.51.10.40.6-0.70.7
Progressive ratio test 1 inactive lever presses2.32.56.40.9-0.1-0.61.90.4-1.30.7-1.81.92.51.61.9-2.02.0
Progressive ratio test 2 active lever presses0.40.40.9-0.81.01.0-0.6-0.90.2-1.00.3-0.30.5-0.2-0.0-0.30.3
Progressive ratio test 2 breakpoint0.50.61.5-1.01.21.2-0.7-1.10.5-1.10.3-0.30.5-0.20.0-0.50.5
Progressive ratio test 2 inactive lever presses0.20.31.4-0.20.70.50.40.1-1.2-0.8-0.30.30.9-0.30.0-0.00.0
Incentive Sensitization - Responses2.02.14.1-1.71.71.7-2.0-1.40.8-1.71.5-1.5-0.9-1.3-1.30.9-0.9
Incentive Sensitization - Breakpoint1.71.73.7-1.51.41.5-1.9-1.20.7-1.51.4-1.4-0.8-1.2-1.20.9-0.9
Sum of active levers in priming session hrs 5-60.10.10.3-0.30.30.30.0-0.50.3-0.3-0.10.10.6-0.00.2-0.30.3
Progressive ratio0.91.03.50.4-0.6-0.6-0.50.8-1.0-0.10.7-0.7-1.2-0.8-1.41.9-1.9
Food seeking constrained by brief footshock0.50.62.0-0.20.00.00.3-0.51.00.4-0.40.40.51.11.0-1.41.4
Seeking ratio, punishment vs. effort1.51.85.3-1.21.01.2-0.3-1.72.3-0.0-0.10.10.60.91.3-2.22.2
Retroperitoneal fat weight0.10.20.60.5-0.4-0.40.8-0.1-0.30.6-0.30.30.10.70.5-0.60.6
Reaction time number correct0.60.93.1-1.00.71.2-1.7-1.41.3-0.20.9-0.9-1.0-0.5-0.2-0.30.3
Reaction time mean minus median0.71.02.10.8-0.6-0.91.40.9-0.80.3-1.21.21.41.01.1-0.90.9
Reaction time mean minus median AUC1.92.54.81.3-1.1-1.42.21.3-1.20.6-1.91.92.11.71.7-1.51.5
Reaction time num false alarms0.81.01.70.8-0.9-0.81.10.5-0.41.0-1.21.21.31.11.2-1.11.1
Reaction time num false alarms AUC0.81.12.30.5-0.6-0.50.90.00.30.9-1.11.11.41.31.4-1.51.5
Reaction time trials correct on left0.60.93.1-1.00.71.2-1.7-1.41.3-0.20.9-0.9-1.0-0.5-0.2-0.30.3
Reaction time trials on left0.60.92.9-0.90.71.1-1.7-1.41.3-0.10.8-0.8-1.0-0.5-0.2-0.40.4
Reaction time mean2.12.96.41.7-1.3-1.72.52.0-2.50.8-2.02.02.01.41.3-0.70.7
Reaction time mean AUC2.33.16.41.7-1.4-1.82.52.0-2.40.9-2.02.02.01.51.4-0.80.8
Median of all reaction times2.23.07.51.8-1.4-1.82.52.1-2.70.9-2.02.01.81.31.2-0.50.5
Reaction time omissions0.30.41.40.4-0.5-0.40.40.30.31.2-0.60.60.30.70.9-0.90.9
Reaction time false alarm rate1.21.73.41.0-1.0-1.21.80.9-0.60.9-1.51.51.81.51.4-1.21.1
Reaction time premature initiation rate0.20.30.9-0.30.20.4-0.9-0.81.00.20.5-0.5-0.60.0-0.1-0.20.2
Reaction time premature initiations0.70.92.8-0.90.71.1-1.7-1.51.5-0.11.0-1.0-1.1-0.4-0.3-0.20.2
Std. dev. reaction times1.82.65.01.6-1.3-1.62.21.7-1.81.0-1.91.91.81.51.5-1.11.1
Reaction time trials completed0.60.92.9-0.90.71.1-1.7-1.41.3-0.10.8-0.8-1.0-0.5-0.2-0.40.4
Reaction time trials AUC0.50.82.7-0.90.71.1-1.6-1.31.2-0.10.8-0.8-0.9-0.5-0.2-0.30.3
Run reversals in cocaine runway, females0.20.20.6-0.50.40.50.2-0.70.8-0.2-0.10.10.30.30.4-0.60.6
Run reversals in cocaine runway, males0.80.71.60.8-1.2-0.80.10.20.11.3-0.70.70.51.01.1-1.11.1
Latency to leave start box in cocaine runway1.01.02.7-1.50.91.2-0.9-1.01.6-0.71.2-1.2-1.0-0.8-0.70.3-0.3
Latency to leave start box in cocaine runway, F0.10.10.9-0.2-0.10.1-0.2-0.30.90.40.1-0.1-0.20.30.3-0.50.5
Latency to leave start box in cocaine runway, M3.43.36.0-2.51.82.0-1.4-1.61.8-2.02.0-2.0-1.5-1.8-1.71.3-1.3
Std. dev. time between licks in bursts0.60.72.40.0-0.30.3-1.5-0.10.30.80.8-0.8-1.6-0.8-0.80.9-0.9
Total sessions with >9 infusions1.01.12.90.50.30.10.7-0.6-0.40.2-1.11.11.71.01.3-1.61.6
Short access day 1 total inactive lever presses1.11.23.0-1.11.61.40.1-1.30.1-1.1-0.40.51.70.20.9-1.51.5
Short access day 10 total inactive lever presses0.80.92.40.4-0.1-0.31.30.6-0.80.3-1.11.11.61.01.1-1.11.1
Short access day 1 total infusions0.40.41.70.00.30.20.7-0.0-0.5-0.2-0.70.71.30.30.7-0.80.8
Short access day 10 total infusions0.80.92.80.40.1-0.31.50.5-1.1-0.1-1.11.11.70.61.0-1.01.0
Short access total infusions1.61.84.90.8-0.2-0.61.80.6-1.40.2-1.61.62.21.21.5-1.51.5
Short access day 1 locomotion0.10.10.2-0.20.20.30.2-0.4-0.0-0.1-0.20.20.50.20.3-0.40.4
Short access day 10 total locomotion0.30.41.2-1.01.10.80.6-0.40.2-0.6-0.10.20.7-0.10.4-0.60.6
Short access total locomotion0.70.72.20.20.1-0.21.50.6-1.0-0.0-1.11.11.50.60.9-0.80.8
One hour access (0.3 mA shock)0.50.62.1-1.21.41.0-0.2-0.70.1-1.40.6-0.50.2-0.7-0.60.4-0.4
Compulsive drug intake0.50.51.5-0.91.20.9-0.5-1.00.5-0.90.6-0.6-0.2-0.4-0.50.3-0.2
One hour access (shock baseline)0.10.10.60.00.0-0.10.80.6-0.5-0.3-0.40.40.6-0.10.2-0.00.0
Social response proportion1.92.13.6-1.31.21.4-1.5-0.90.7-1.51.6-1.6-1.3-1.9-1.71.6-1.6
Social responses0.10.10.4-0.30.10.3-0.6-0.30.5-0.20.4-0.4-0.4-0.5-0.40.3-0.3
Social time0.20.30.6-0.40.50.50.3-0.60.4-0.7-0.20.20.80.20.5-0.80.8
Soleus weight8.424.749.5-5.64.85.6-6.6-6.47.0-3.45.6-5.6-4.8-3.8-3.41.4-1.3
Bone: stiffness0.71.23.0-1.41.41.5-1.2-1.71.6-1.20.8-0.70.0-0.6-0.1-0.50.5
Tibialis anterior weight7.826.551.6-6.56.06.4-6.3-7.26.8-4.45.3-5.3-3.9-3.6-3.00.7-0.6
Time to tail flick, vehicle, before self-admin2.02.17.42.0-2.4-2.10.81.3-0.32.7-0.90.9-0.31.30.9-0.50.5
Time to tail flick, vehicle, after self-admin0.70.81.7-1.31.31.2-0.9-1.10.7-1.20.7-0.7-0.2-0.7-0.60.3-0.3
Time to tail flick, test, before self-admin0.90.81.91.0-1.2-0.9-0.31.2-0.80.70.2-0.2-1.1-0.5-0.81.4-1.4
Time to tail flick, test, after self-admin2.02.13.71.4-1.0-1.21.91.2-1.31.0-1.71.71.81.51.5-1.31.3
Delta time to tail flick, vehicle, before/after SA1.91.86.0-2.02.31.9-0.7-1.10.1-2.50.9-0.80.2-1.2-1.00.7-0.7
Delta time to tail flick, test, before/after SA1.11.03.2-0.51.00.51.2-0.5-0.2-0.6-0.80.81.80.81.1-1.51.5
Tibia length1.13.27.3-2.12.21.6-1.0-0.90.4-2.71.7-1.7-1.0-1.9-2.22.1-2.1
Ambulatory time before self-admin0.10.10.30.5-0.3-0.20.40.5-0.10.1-0.30.30.3-0.10.10.1-0.1
Ambulatory time after self-admin1.61.85.4-1.92.32.1-0.9-1.91.2-2.00.7-0.70.5-0.7-0.3-0.40.4
Bone: tissue strength0.60.61.90.7-0.5-0.71.10.9-1.40.0-0.80.80.90.60.4-0.20.2
Total heroin consumption0.30.31.8-0.30.10.3-0.6-0.81.40.20.3-0.3-0.30.10.3-0.70.7
Bone: trabecular number0.40.71.51.2-1.2-1.00.31.1-1.01.1-0.80.80.30.60.4-0.10.0
Bone: trabecular spacing0.10.10.80.3-0.2-0.30.90.30.00.0-0.30.30.40.30.3-0.10.1
Bone: trabecular thickness0.91.02.9-1.41.71.4-0.8-1.1-0.2-1.70.7-0.70.1-1.0-0.70.4-0.4
Bone: trabecular tissue density7.610.721.3-4.54.64.6-3.2-4.22.9-4.03.1-3.0-1.4-3.1-2.10.8-0.8
Water consumed over 24 hours0.10.10.5-0.40.5-0.00.50.1-0.3-0.7-0.10.10.40.1-0.20.2-0.2
Number of responses in last shaping day0.10.10.3-0.00.10.10.2-0.2-0.30.1-0.30.30.50.30.3-0.40.4