Hub : Genes

C15h8orf58

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	NM_001134571.3	0.02	0.02	8.7e-03	0.01	0.01	0.01	0.01	4.1e-02	6.2e-02	3.4e-02	7.2e-02
2	IL	alternative TSS	XM_063274432.1	0.17	0.16	5.2e-03	0.05	0.04	0.05	0.04	2.4e-02	3.9e-02	2.5e-02	3.4e-02
3	IL	alternative TSS	NM_001134571.3	0.17	0.15	6.4e-03	0.05	0.04	0.04	0.04	3.0e-02	4.9e-02	3.2e-02	4.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.3	2.3	2.5	-1.6	-1.6	1.4
Area under the delay curve	0.1	0.1	0.1	0.4	0.3	-0.3
BMI with tail	0.4	1.5	1.7	1.1	1.2	-1.3
BMI without tail	0.0	0.0	0.0	0.1	0.1	-0.0
Body weight	0.6	2.8	3.2	1.6	1.6	-1.8
Weight adjusted by age	0.7	2.2	2.2	1.5	1.5	-1.5
Bone surface	0.6	1.2	1.3	-1.1	-1.2	1.1
Bone volume	0.7	1.3	1.4	-1.2	-1.2	1.1
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.2	0.5	-0.2
Number of licking bursts	0.0	0.0	0.0	0.1	-0.0	0.0
Context. condit. distance diff. score	0.8	1.0	1.0	-1.0	-1.0	1.0
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	0.4	-0.4
Locomotion distance, session 1	0.0	0.0	0.0	0.0	-0.0	0.1
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	-0.3	0.2
Locomotion distance, session 2	0.0	0.0	0.1	-0.1	-0.2	0.3
Locomotion velocity, session 3	0.5	0.6	0.7	0.9	0.8	-0.7
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	-0.1	0.2
Stereotopy head waving bouts, day 3	0.8	0.9	1.0	1.0	1.0	-0.8
Stereotopy head waving duration, day 3	2.5	3.1	3.2	1.8	1.8	-1.7
Locomotion velocity, session 7	4.2	4.6	4.7	-2.1	-2.2	2.2
Locomotion distance, session 7	3.4	4.3	4.5	-2.0	-2.1	2.1
Stereotopy head waving bouts, day 7	1.3	1.5	1.6	1.2	1.2	-1.3
Stereotopy head waving duration, day 7	1.9	2.4	2.6	1.5	1.5	-1.6
Locomotion velocity, session 8	0.0	0.0	0.0	0.0	-0.1	0.2
Locomotion distance, session 8	0.6	0.9	1.1	-0.9	-1.0	1.0
Degree of sensitization distance	4.5	4.8	4.9	-2.2	-2.2	2.2
Degree of sensitization stereotypy	0.9	1.0	1.2	1.0	1.0	-1.1
Conditioned locomotion	0.0	0.0	0.0	-0.2	-0.2	0.2
Cocaine response after cond. corrected	0.2	0.3	0.4	0.5	0.7	-0.5
Cocaine response after cond. not corrected	0.1	0.2	0.3	0.4	0.5	-0.4
Cocaine response before conditioning	0.2	0.2	0.2	-0.4	-0.5	0.4
Saline control response	0.1	0.1	0.2	-0.4	-0.3	0.4
Bone: connectivity density	2.6	4.1	4.4	-2.1	-2.1	1.9
Bone: cortical apparent density	0.1	0.1	0.1	-0.3	-0.2	0.4
Bone: cortical area	0.0	0.0	0.0	-0.1	-0.1	0.1
Bone: cortical porosity	1.1	1.2	1.3	1.1	1.1	-1.1
Bone: cortical porosity	0.6	0.7	0.7	0.9	0.8	-0.8
Bone: cortical thickness	0.0	0.0	0.0	-0.0	-0.0	0.2
Bone: cortical thickness	0.0	0.0	0.0	-0.0	-0.0	0.1
Bone: cortical tissue density	0.1	0.1	0.2	-0.3	-0.3	0.4
Condit. Reinf. active minus inactive responses	0.6	0.7	0.8	0.9	0.9	-0.7
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.1	1.8	1.7	-1.4
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	0.1	0.0
Condit. Reinf. inactive responses	2.3	3.0	3.3	-1.8	-1.8	1.6
Incentive salience index mean	0.8	1.1	1.3	1.1	1.1	-0.9
Condit. Reinf. lever presses	0.3	0.5	0.7	0.8	0.7	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.4	0.4	-0.7	-0.6	0.7
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	0.3	0.3	-0.2
Condit. Reinf. active responses	0.9	1.3	1.3	-1.1	-1.1	1.1
Condit. Reinf. inactive responses	1.8	2.6	2.6	-1.6	-1.6	1.6
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.4	-0.5	0.4
Condit. Reinf. lever reinforcers received	0.7	1.0	1.0	-1.0	-1.0	1.0
Conditioned reinforcement - actives	0.4	1.7	1.8	-1.3	-1.3	1.3
Conditioned reinforcement - inactives	1.7	4.7	4.9	-2.2	-2.1	2.2
Conditioned locomotion	0.1	0.2	0.3	-0.4	-0.4	0.5
Patch foraging indifference point 0 sec	1.2	3.3	3.7	-1.9	-1.7	1.8
Patch foraging indifference point AUC	0.2	0.4	0.5	0.7	0.7	-0.6
Delay disc. indifference point, 0s delay	0.2	0.3	0.3	-0.5	-0.5	0.5
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.4	-0.4	0.6
Delay disc. indifference point, 2s delay	1.5	1.7	1.7	1.3	1.3	-1.3
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	0.5	0.5	-0.5
Delay disc. indifference point, 4s delay	1.9	2.0	2.1	1.5	1.4	-1.4
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	-0.1	0.2
Indifference point function ln k	0.0	0.0	0.0	-0.2	-0.1	0.1
Indifference point function log k	0.0	0.0	0.0	-0.2	-0.1	0.1
Patch foraging total patch changes 0 sec	0.8	2.4	2.7	-1.7	-1.5	1.5
Patch foraging total patch changes 12 sec	0.5	0.7	0.8	-0.9	-0.8	0.9
Patch foraging total patch changes 18 sec	0.7	1.7	1.9	-1.3	-1.3	1.4
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	0.1	0.2	-0.0
Patch foraging total patch changes 6 sec	0.2	0.3	0.3	-0.6	-0.5	0.5
Patch foraging time to switch 0 sec	0.3	1.1	1.1	-1.0	-1.1	1.1
Patch foraging water rate 0 sec	0.1	0.4	0.5	0.5	0.7	-0.7
Patch foraging water rate 12 sec	0.2	0.9	1.0	0.9	0.9	-1.0
Patch foraging water rate 18 sec	1.6	3.7	4.2	1.8	1.9	-2.0
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.1	0.3	-0.5
Patch foraging water rate 6 sec	1.9	2.8	2.9	1.7	1.6	-1.7
Seeking ratio, delayed vs. immediate footshock	0.9	1.3	1.5	-1.2	-1.2	1.0
Distance traveled before self-admin	0.5	1.0	1.1	1.0	1.0	-1.0
Distance traveled after self-admin	1.8	3.1	3.3	1.8	1.7	-1.8
Extensor digitorum longus weight	12.9	51.5	52.8	7.1	7.3	-7.1
Bone: elastic displacement	0.3	0.4	0.5	-0.6	-0.6	0.7
Bone: elastic work	0.2	0.3	0.3	-0.5	-0.5	0.6
Bone: endosteal estimation	0.0	0.1	0.1	0.3	0.2	-0.4
Bone: endosteal perimeter	0.0	0.0	0.1	0.2	0.1	-0.3
Epididymis fat weight	0.5	2.7	3.0	-1.6	-1.6	1.7
Delta time in closed arm before/after self-admin	3.8	3.6	3.6	-1.9	-1.9	1.9
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	0.2	-0.1
Diff in mean of infusions in LGA sessions	0.7	1.2	1.6	1.1	1.3	-0.9
Delay discount exponential model param	0.4	0.5	0.6	-0.7	-0.7	0.6
Extinction: sum of active levers before priming	1.5	2.2	2.4	-1.5	-1.4	1.5
Active lever presses in extinction session 6	0.4	0.4	0.7	-0.6	-0.4	0.8
Bone: final force	0.1	0.1	0.2	0.4	0.4	-0.3
Bone: final moment	0.1	0.1	0.1	0.3	0.3	-0.3
Food consumed during 24 hour testing period	0.2	0.3	0.3	-0.5	-0.6	0.6
Glucose	0.0	0.0	0.0	0.1	-0.0	0.1
Heart weight	0.5	0.8	0.8	-0.9	-0.9	0.9
Delay discount hyperbolic model param	0.5	0.6	0.7	-0.8	-0.8	0.7
Intermittent access intake day 1-15 change	0.6	3.6	3.7	-1.9	-1.9	1.9
Intermittent access intake escalation	0.7	3.7	3.9	-1.9	-1.9	2.0
Intermittent access intake escalation 2	1.0	1.7	1.8	-1.3	-1.3	1.3
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.1	-0.1	0.1
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.2	-0.2	0.2
Intermitt. access escalation Index	0.0	0.1	0.1	0.3	0.2	-0.2
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.0	0.0	-0.0
Intermittent access day 15 total infusions	1.0	2.5	2.6	-1.6	-1.6	1.6
Intermittent access terminal intake (last 3 days)	0.8	1.4	1.5	-1.2	-1.2	1.2
Intermittent access total infusions	1.2	1.4	1.5	-1.2	-1.2	1.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	-0.1	0.1
Intermittent access day 15 total locomotion	0.1	0.4	0.5	-0.6	-0.6	0.7
Intermittent access total locomotion	0.1	0.1	0.2	-0.3	-0.3	0.4
Intermittent access standard deviation	0.1	0.3	0.4	-0.5	-0.5	0.6
Left kidney weight	0.0	0.1	0.2	0.3	0.3	-0.5
Right kidney weight	0.0	0.0	0.1	0.1	0.1	-0.3
Cocaine induced anxiety	0.0	0.0	0.0	0.1	0.1	-0.0
Post-drug Anxiety	0.8	0.9	1.0	-0.9	-0.9	1.0
Baseline Anxiety	0.3	0.5	0.5	-0.6	-0.6	0.7
Tail length	0.4	1.9	2.0	-1.3	-1.4	1.4
Length with tail	0.0	0.2	0.2	0.4	0.4	-0.4
Length without tail	1.3	7.0	7.4	2.6	2.6	-2.7
Times rat made contact with spout	0.5	0.6	0.6	-0.7	-0.8	0.8
Lifetime Intake	0.7	0.9	0.9	-0.9	-0.9	1.0
Liver weight, left	1.8	3.1	3.2	1.8	1.8	-1.7
Liver weight, right	0.5	0.8	0.8	0.9	0.9	-0.9
Locomotor activity	1.6	2.5	2.6	1.5	1.5	-1.6
Locomotor testing distance	0.0	0.0	0.1	-0.2	-0.3	0.2
Locomotor testing rearing	0.1	0.3	0.3	-0.5	-0.5	0.4
Locomotion in novel chamber	0.5	0.6	0.6	-0.8	-0.8	0.8
Locomotion in novel chamber post-restriction	0.3	1.0	1.3	0.9	0.9	-1.2
Fecal boli incidents, locomotor time 1	0.6	1.5	1.6	1.3	1.3	-1.1
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.5	0.5	-0.5
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.2	-0.9	-0.9	1.1
Bouts of movement, locomotor time 1	4.3	5.6	5.7	2.4	2.4	-2.3
Total resting periods, locomotor time 1	4.7	5.5	5.5	2.4	2.4	-2.3
Rest time, locomotor task time 1	1.5	2.5	2.5	1.6	1.6	-1.6
Distance moved, locomotor task time 1	1.2	3.4	3.7	-1.8	-1.8	1.9
Vertical activity count, locomotor time 1	0.2	1.2	1.3	-1.1	-1.1	1.0
Time >=10cm from walls, locomotor time 2	0.2	0.5	0.6	0.6	0.6	-0.8
Bouts of movement, locomotor time 2	1.6	5.2	5.2	2.3	2.3	-2.3
Total resting periods, locomotor time 2	1.4	5.6	5.7	2.3	2.3	-2.4
Rest time, locomotor task time 2	0.7	1.2	1.6	1.0	1.0	-1.3
Distance moved, locomotor task time 2	2.8	3.7	3.9	-1.9	-1.9	2.0
Vertical activity count, locomotor time 2	0.2	0.5	0.5	-0.7	-0.7	0.7
Light reinforcement 1	1.2	5.6	5.8	-2.4	-2.4	2.3
Light reinforcement 2	0.6	1.3	1.4	-1.1	-1.1	1.2
Bone: marrow area	0.0	0.0	0.1	0.1	0.1	-0.2
Bone: maximum diameter	0.2	0.5	0.5	0.7	0.7	-0.7
Bone: maximum force	0.2	0.4	0.5	0.7	0.7	-0.6
Bone: maximum moment	0.1	0.2	0.3	0.5	0.5	-0.4
Mean time between licks in bursts	0.4	2.6	2.7	-1.6	-1.6	1.6
Mean num. licks in bursts	0.1	0.3	0.4	-0.6	-0.5	0.6
Cd content in liver	1.2	1.4	1.5	1.2	1.2	-1.1
Co content in liver	5.1	6.0	6.2	2.5	2.5	-2.4
Cu content in liver	0.5	0.6	0.7	0.7	0.8	-0.6
Fe content in liver	1.6	2.0	2.1	-1.4	-1.4	1.4
K content in liver	1.1	1.1	1.2	-1.1	-1.0	1.1
Mg content in liver	2.4	2.7	2.8	-1.7	-1.6	1.7
Mn content in liver	2.5	2.8	2.8	-1.7	-1.7	1.7
Na content in liver	0.9	1.1	1.1	1.0	1.1	-1.0
Rb content in liver	0.0	0.0	0.1	-0.2	-0.2	0.2
Se content in liver	1.0	1.1	1.2	-1.1	-1.0	1.1
Sr content in liver	0.0	0.0	0.0	-0.1	-0.0	0.2
Zn content in liver	0.1	0.1	0.2	-0.3	-0.2	0.4
Bone: minimum diameter	0.1	0.2	0.2	0.4	0.4	-0.5
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.1	0.1	-0.2
Time in novel zone, hab. session 1	1.2	1.3	1.4	1.1	1.2	-1.1
Total zone transitions, hab. session 1	0.2	0.3	0.4	0.6	0.6	-0.4
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	0.0	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.2	-0.3	0.4
Time in familiar zone, hab. session 2	1.8	2.0	2.1	1.5	1.4	-1.4
Time in novel zone, hab. session 2	0.6	0.7	0.7	-0.9	-0.8	0.8
Total zone transitions, hab. session 2	1.5	1.9	1.9	1.4	1.4	-1.4
Total locomotion distance, hab. session 2	0.3	0.4	0.4	0.6	0.6	-0.6
Locomotion velocity, hab. session 2	0.6	0.8	0.8	0.9	0.9	-0.9
Novel to familiar place preference ratio	1.2	1.6	1.7	-1.3	-1.3	1.2
Novelty place preference	1.0	1.3	1.3	-1.2	-1.1	1.1
Time in novel zone, NPP test	0.5	0.6	0.7	-0.8	-0.8	0.8
Total zone transitions, NPP test	0.1	0.2	0.2	-0.4	-0.4	0.4
Total locomotion distance, NPP test	2.4	3.3	3.4	-1.8	-1.8	1.8
Locomotion velocity, NPP test	2.3	3.3	3.4	-1.8	-1.8	1.8
Intraocular pressure	0.4	0.6	0.8	-0.7	-0.7	0.9
Delta distance traveled before/after self-admin	2.9	3.2	3.3	1.8	1.7	-1.8
Delta ambulatory time before/after self-admin	1.9	3.3	3.6	1.8	1.7	-1.9
Parametrial fat weight	2.0	4.8	5.2	-2.3	-2.3	2.0
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.0	0.0	-0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.2	0.3
Pavlov. Cond. change in total contacts	1.0	1.1	1.3	1.1	1.0	-0.9
Pavlov. Cond. index score	0.0	0.1	0.1	0.3	0.2	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	0.1	-0.0
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	-0.1	0.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	-0.7	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	0.5	0.4	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	0.4	-0.3
Pavlov. Cond. lever latency	0.4	0.5	0.6	-0.8	-0.7	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.2	-0.3	0.3
Pavlov. Cond. change in total contacts	0.8	1.9	2.1	1.4	1.3	-1.4
Pavlov. Cond. index score	0.3	0.5	0.6	0.8	0.7	-0.7
Pavlov. Cond. latency score	0.2	0.3	0.4	0.6	0.5	-0.6
Pavlov. Cond. lever contacts	0.2	0.2	0.3	0.6	0.4	-0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	3.6	7.9	8.1	-2.8	-2.9	2.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.7	0.8	0.9	0.8	-0.8
Pavlov. Cond. response bias	0.2	0.3	0.4	0.6	0.5	-0.5
Time in closed arm before self-admin	0.9	1.6	1.8	1.3	1.1	-1.3
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	0.0	-0.2
Time in open arm before self-admin	0.0	0.0	0.0	0.2	0.2	-0.0
Time in open arm after self-admin	0.0	0.0	0.1	-0.1	0.1	0.2
Bone: periosteal estimation	0.0	0.0	0.0	0.2	0.1	-0.2
Bone: periosteal perimeter	0.0	0.0	0.1	0.1	0.1	-0.3
Bone: post-yield work	0.1	0.2	0.3	-0.5	-0.5	0.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.3	0.3	-0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.2	0.4	0.4	-0.4
Progressive ratio test 1 inactive lever presses	0.4	1.2	1.2	-1.1	-1.1	1.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.2	-0.2	0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.2	-0.1	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.5	0.5	-0.7	-0.6	0.7
Incentive Sensitization - Responses	0.1	0.3	0.4	-0.6	-0.6	0.6
Incentive Sensitization - Breakpoint	0.2	0.5	0.5	-0.7	-0.7	0.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.2	-0.1	0.2
Progressive ratio	0.0	0.0	0.0	0.1	0.1	-0.1
Food seeking constrained by brief footshock	2.1	2.6	2.7	1.6	1.6	-1.6
Seeking ratio, punishment vs. effort	0.5	1.0	1.0	1.0	1.0	-1.0
Retroperitoneal fat weight	0.1	0.5	0.6	-0.8	-0.7	0.6
Reaction time number correct	0.3	0.9	1.1	1.0	0.9	-1.1
Reaction time mean minus median	0.0	0.2	0.2	0.5	0.4	-0.5
Reaction time mean minus median AUC	0.0	0.1	0.1	0.3	0.3	-0.4
Reaction time num false alarms	0.0	0.1	0.1	0.3	0.3	-0.3
Reaction time num false alarms AUC	0.0	0.0	0.1	0.2	0.2	-0.3
Reaction time trials correct on left	0.3	0.9	1.1	1.0	0.9	-1.1
Reaction time trials on left	0.2	0.7	0.9	0.9	0.7	-0.9
Reaction time mean	0.1	0.3	0.3	0.6	0.5	-0.5
Reaction time mean AUC	0.2	0.5	0.6	0.8	0.7	-0.7
Median of all reaction times	0.1	0.2	0.3	0.5	0.5	-0.4
Reaction time omissions	1.5	2.4	2.5	-1.6	-1.6	1.6
Reaction time false alarm rate	0.1	0.1	0.1	-0.4	-0.3	0.3
Reaction time premature initiation rate	1.6	2.5	2.9	1.5	1.7	-1.6
Reaction time premature initiations	1.2	3.7	3.8	1.8	2.0	-1.9
Std. dev. reaction times	0.1	0.2	0.2	0.5	0.4	-0.5
Reaction time trials completed	0.2	0.7	0.9	0.9	0.7	-0.9
Reaction time trials AUC	0.2	0.6	0.8	0.8	0.7	-0.9
Run reversals in cocaine runway, females	2.8	3.1	3.3	-1.7	-1.8	1.8
Run reversals in cocaine runway, males	1.8	2.0	2.0	1.4	1.4	-1.4
Latency to leave start box in cocaine runway	0.3	0.5	0.6	0.6	0.6	-0.8
Latency to leave start box in cocaine runway, F	1.2	1.5	1.8	1.2	1.2	-1.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	-0.3	0.3
Std. dev. time between licks in bursts	0.9	1.7	1.7	-1.3	-1.3	1.3
Total sessions with >9 infusions	0.0	0.0	0.0	0.2	0.2	-0.2
Short access day 1 total inactive lever presses	0.1	0.2	0.2	-0.4	-0.4	0.4
Short access day 10 total inactive lever presses	0.0	0.2	0.3	-0.5	-0.5	0.4
Short access day 1 total infusions	0.0	0.1	0.1	0.2	0.2	-0.2
Short access day 10 total infusions	0.2	0.3	0.4	0.6	0.6	-0.6
Short access total infusions	0.0	0.0	0.0	0.2	0.2	-0.2
Short access day 1 locomotion	0.6	1.0	1.0	1.0	1.0	-1.0
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	-0.1	-0.1
Short access total locomotion	0.1	0.1	0.1	0.3	0.3	-0.3
One hour access (0.3 mA shock)	0.7	0.8	0.8	-0.9	-0.9	0.9
Compulsive drug intake	0.5	0.7	0.8	-0.9	-0.9	0.8
One hour access (shock baseline)	0.0	0.0	0.0	0.0	0.0	0.1
Social response proportion	0.1	0.1	0.1	0.2	0.3	-0.3
Social responses	1.1	1.4	1.5	-1.2	-1.2	1.1
Social time	0.4	0.7	0.7	-0.9	-0.8	0.8
Soleus weight	1.3	3.8	3.9	1.9	2.0	-1.9
Bone: stiffness	0.5	1.0	1.1	1.0	1.0	-0.9
Tibialis anterior weight	8.4	28.8	29.6	5.3	5.4	-5.3
Time to tail flick, vehicle, before self-admin	0.6	0.8	0.9	-0.9	-0.8	1.0
Time to tail flick, vehicle, after self-admin	0.9	1.9	2.2	1.4	1.5	-1.2
Time to tail flick, test, before self-admin	2.5	2.8	3.0	-1.7	-1.7	1.7
Time to tail flick, test, after self-admin	2.2	2.3	2.6	-1.5	-1.6	1.5
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.2	0.4	0.5	-0.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	-0.1	-0.2	0.1
Tibia length	1.4	3.8	4.1	-1.9	-2.0	1.9
Ambulatory time before self-admin	0.1	0.4	0.5	0.7	0.7	-0.6
Ambulatory time after self-admin	3.8	6.1	6.4	2.5	2.4	-2.5
Bone: tissue strength	0.1	0.1	0.1	-0.3	-0.3	0.2
Total heroin consumption	0.4	0.5	0.6	0.6	0.8	-0.8
Bone: trabecular number	2.1	4.0	4.2	-2.0	-2.1	1.9
Bone: trabecular spacing	2.1	3.1	3.1	1.7	1.8	-1.8
Bone: trabecular thickness	1.0	1.4	1.5	-1.2	-1.2	1.2
Bone: trabecular tissue density	1.2	2.0	2.2	1.5	1.4	-1.4
Water consumed over 24 hours	0.9	1.7	1.9	1.4	1.3	-1.3
Number of responses in last shaping day	0.5	0.6	0.7	0.8	0.8	-0.7