Hub : Genes

Lgi3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Lgi3 0.17 0.13 4.9e-03 0 0.07 0 0.02 2.8e-01 1.0e-02 3.3e-01 9.4e-02
2 NAcc gene expression Lgi3 0.03 0.02 8.8e-05 0.02 0.02 0.02 0.02 1.9e-04 1.1e-04 4.2e-04 1.9e-04
3 IC gene expression Lgi3 0.11 0.07 5.9e-05 0.07 0.08 0.08 0.08 7.0e-04 3.8e-04 2.5e-04 2.7e-04
4 Brain gene expression Lgi3 0.09 0.06 1.4e-09 0.11 0.11 0.11 0.11 2.9e-10 4.4e-10 4.0e-10 4.0e-10
5 PL gene expression Lgi3 0.05 0.04 7.2e-07 0.05 0.05 0.05 0.05 2.3e-06 1.5e-06 5.2e-06 4.0e-06
6 OFC gene expression Lgi3 0.3 0.19 1.6e-03 0.06 0.05 0.05 0.05 1.9e-02 2.8e-02 2.4e-02 2.7e-02
7 pVTA gene expression Lgi3 0.04 0.03 4.8e-04 0.04 0.04 0.04 0.04 2.6e-04 2.8e-04 5.0e-04 5.9e-04
8 BLA gene expression Lgi3 0.14 0.09 7.5e-07 0.08 0.09 0.08 0.08 3.7e-05 2.3e-05 4.4e-05 5.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.92.21.51.4-1.4-1.41.4-1.3-1.31.3
Area under the delay curve0.00.10.1-0.0-0.20.20.2-0.30.30.3-0.3
BMI with tail0.41.52.8-1.7-1.31.11.1-1.21.11.1-1.0
BMI without tail0.00.10.3-0.6-0.1-0.2-0.10.1-0.3-0.30.3
Body weight0.62.73.0-1.7-1.71.61.6-1.71.61.6-1.7
Weight adjusted by age0.72.22.3-1.3-1.51.51.5-1.51.51.5-1.5
Bone surface0.50.91.71.31.1-0.9-1.01.0-0.7-0.70.8
Bone volume0.61.11.81.31.1-1.0-1.11.1-0.9-0.90.9
Breakpoint value in progressive ratio session0.00.10.1-0.2-0.30.30.3-0.30.30.3-0.3
Number of licking bursts0.00.00.0-0.10.0-0.1-0.10.0-0.1-0.10.1
Context. condit. distance diff. score1.01.22.2-0.00.9-1.2-1.11.1-1.2-1.21.5
Locomotion velocity, session 10.20.20.2-0.3-0.40.50.5-0.40.50.5-0.5
Locomotion distance, session 10.10.10.60.70.3-0.2-0.20.1-0.3-0.3-0.1
Locomotion velocity, session 20.00.10.20.50.2-0.2-0.10.1-0.2-0.20.0
Locomotion distance, session 20.10.21.11.00.3-0.2-0.10.1-0.2-0.2-0.3
Locomotion velocity, session 30.60.61.5-1.2-0.80.80.7-0.70.80.8-0.5
Locomotion distance, session 30.00.00.1-0.20.1-0.1-0.20.2-0.1-0.10.4
Stereotopy head waving bouts, day 30.60.70.8-0.8-0.90.80.9-0.90.80.8-0.9
Stereotopy head waving duration, day 32.22.83.0-1.5-1.71.71.7-1.71.61.6-1.7
Locomotion velocity, session 73.94.26.70.91.9-2.1-2.12.3-2.1-2.12.6
Locomotion distance, session 73.03.85.51.11.9-2.0-2.02.1-2.0-2.02.4
Stereotopy head waving bouts, day 71.51.82.1-1.0-1.31.41.4-1.41.41.4-1.4
Stereotopy head waving duration, day 72.22.73.0-1.4-1.61.71.6-1.61.71.7-1.7
Locomotion velocity, session 80.00.00.1-0.3-0.0-0.00.00.1-0.0-0.00.2
Locomotion distance, session 80.71.11.40.91.0-1.1-0.91.0-1.2-1.21.0
Degree of sensitization distance4.04.35.21.62.0-2.1-2.12.2-2.1-2.12.3
Degree of sensitization stereotypy1.11.21.3-1.0-1.11.11.1-1.11.11.1-1.2
Conditioned locomotion0.00.00.1-0.20.1-0.2-0.20.2-0.2-0.20.3
Cocaine response after cond. corrected0.30.41.5-1.2-0.70.60.6-0.50.50.5-0.2
Cocaine response after cond. not corrected0.20.20.8-0.9-0.50.40.4-0.40.40.4-0.2
Cocaine response before conditioning0.20.31.01.00.5-0.4-0.40.4-0.5-0.50.1
Saline control response0.10.20.60.80.4-0.3-0.30.3-0.2-0.20.1
Bone: connectivity density2.23.63.71.91.9-1.9-1.91.9-1.9-1.91.9
Bone: cortical apparent density0.10.10.4-0.40.2-0.3-0.30.4-0.3-0.30.6
Bone: cortical area0.00.00.10.30.10.10.00.00.10.1-0.1
Bone: cortical porosity1.11.21.8-0.6-1.11.11.1-1.21.11.1-1.3
Bone: cortical porosity0.60.71.2-0.3-0.80.90.9-0.90.80.8-1.1
Bone: cortical thickness0.00.00.00.20.10.0-0.00.10.10.10.0
Bone: cortical thickness0.00.10.2-0.4-0.0-0.2-0.00.1-0.3-0.30.3
Bone: cortical tissue density0.10.20.4-0.40.2-0.3-0.30.4-0.4-0.40.7
Condit. Reinf. active minus inactive responses0.40.40.7-0.4-0.70.70.7-0.70.60.6-0.8
Condit. Reinf. active-inactive response ratio2.12.22.5-1.6-1.51.51.6-1.51.41.4-1.4
Condit. Reinf. active responses0.00.00.30.50.1-0.00.0-0.1-0.0-0.0-0.2
Condit. Reinf. inactive responses2.53.25.92.41.9-1.7-1.71.6-1.7-1.71.4
Incentive salience index mean0.60.71.4-0.3-0.80.91.0-1.00.80.8-1.2
Condit. Reinf. lever presses0.20.30.80.1-0.50.50.7-0.70.40.4-0.9
Condit. Reinf. active minus inactive responses0.30.40.40.60.7-0.6-0.70.7-0.6-0.60.7
Condit. Reinf. active-inactive response ratio0.00.10.2-0.4-0.30.30.2-0.20.30.3-0.1
Condit. Reinf. active responses0.91.21.31.11.1-1.1-1.11.1-1.1-1.11.1
Condit. Reinf. inactive responses1.82.63.11.81.6-1.6-1.61.6-1.7-1.71.5
Condit. Reinf. lever presses0.20.30.90.90.5-0.5-0.50.4-0.6-0.60.2
Condit. Reinf. lever reinforcers received0.70.91.11.01.0-1.0-1.01.0-0.9-0.90.9
Conditioned reinforcement - actives0.41.71.91.01.3-1.3-1.31.3-1.3-1.31.4
Conditioned reinforcement - inactives1.74.76.42.52.2-2.1-2.12.1-2.1-2.11.9
Conditioned locomotion0.10.20.20.30.4-0.4-0.40.4-0.4-0.40.5
Patch foraging indifference point 0 sec1.13.07.52.71.9-1.5-1.71.6-1.2-1.21.3
Patch foraging indifference point AUC0.10.30.8-0.9-0.60.50.5-0.50.50.5-0.3
Delay disc. indifference point, 0s delay0.40.51.21.10.7-0.6-0.70.6-0.5-0.50.4
Delay disc. indifference point, 16s delay0.20.30.30.60.5-0.5-0.50.5-0.5-0.50.5
Delay disc. indifference point, 2s delay1.41.51.9-0.8-1.21.31.2-1.31.31.3-1.4
Delay disc. indifference point, 24s delay0.10.20.4-0.6-0.40.40.3-0.40.30.3-0.3
Delay disc. indifference point, 4s delay1.71.81.8-1.3-1.31.31.3-1.31.31.3-1.3
Delay disc. indifference point, 8s delay0.00.00.10.40.2-0.2-0.20.2-0.2-0.20.2
Indifference point function ln k0.00.00.20.50.1-0.10.0-0.0-0.2-0.2-0.2
Indifference point function log k0.00.00.20.50.1-0.10.0-0.0-0.2-0.2-0.2
Patch foraging total patch changes 0 sec0.82.26.12.51.7-1.3-1.51.4-1.0-1.01.0
Patch foraging total patch changes 12 sec0.60.82.21.51.0-0.7-0.90.8-0.5-0.50.6
Patch foraging total patch changes 18 sec0.82.02.71.61.5-1.4-1.51.4-1.2-1.21.3
Patch foraging total patch changes 24 sec0.00.10.40.60.10.2-0.0-0.10.30.3-0.3
Patch foraging total patch changes 6 sec0.20.30.50.70.6-0.4-0.60.5-0.3-0.30.5
Patch foraging time to switch 0 sec0.31.11.20.91.0-1.1-1.01.1-1.1-1.11.1
Patch foraging water rate 0 sec0.10.50.8-0.4-0.70.70.7-0.80.70.7-0.9
Patch foraging water rate 12 sec0.21.01.2-0.7-1.01.01.0-1.01.01.0-1.1
Patch foraging water rate 18 sec1.94.24.8-2.2-2.12.12.1-2.12.02.0-2.0
Patch foraging water rate 24 sec0.20.20.7-0.8-0.60.40.5-0.50.30.3-0.4
Patch foraging water rate 6 sec1.92.83.6-1.1-1.61.71.7-1.71.81.8-1.9
Seeking ratio, delayed vs. immediate footshock0.71.01.41.21.1-1.0-1.01.0-1.0-1.00.9
Distance traveled before self-admin0.51.01.5-0.4-0.91.01.0-1.01.11.1-1.2
Distance traveled after self-admin1.83.23.5-1.9-1.81.81.8-1.81.71.7-1.7
Extensor digitorum longus weight12.549.951.4-7.0-7.27.27.1-7.17.07.0-7.0
Bone: elastic displacement0.50.61.21.10.8-0.7-0.70.7-0.8-0.80.5
Bone: elastic work0.30.41.61.30.7-0.5-0.50.5-0.5-0.50.2
Bone: endosteal estimation0.10.20.2-0.0-0.30.40.4-0.40.50.5-0.5
Bone: endosteal perimeter0.00.10.20.2-0.20.30.3-0.30.40.4-0.5
Epididymis fat weight0.62.93.51.51.6-1.8-1.71.6-1.9-1.91.6
Delta time in closed arm before/after self-admin4.13.95.42.32.0-2.0-1.91.9-1.9-1.91.7
Delta time in open arm before/after self-admin0.10.10.1-0.4-0.30.30.2-0.20.20.2-0.2
Diff in mean of infusions in LGA sessions0.61.01.1-0.9-1.01.01.0-1.01.01.0-1.0
Delay discount exponential model param0.30.30.40.40.6-0.6-0.60.6-0.6-0.60.6
Extinction: sum of active levers before priming1.52.32.51.61.6-1.5-1.51.5-1.5-1.51.5
Active lever presses in extinction session 60.70.70.80.60.8-0.9-0.80.9-0.9-0.90.9
Bone: final force0.10.20.2-0.2-0.40.50.4-0.40.50.5-0.5
Bone: final moment0.10.10.20.0-0.30.40.4-0.40.40.4-0.5
Food consumed during 24 hour testing period0.20.41.01.00.7-0.6-0.60.5-0.7-0.70.4
Glucose0.00.00.1-0.4-0.10.1-0.00.10.10.10.2
Heart weight0.30.51.01.00.8-0.6-0.70.8-0.5-0.50.7
Delay discount hyperbolic model param0.30.40.50.50.6-0.7-0.70.7-0.7-0.70.7
Intermittent access intake day 1-15 change0.63.53.61.81.9-1.9-1.91.9-1.9-1.91.9
Intermittent access intake escalation0.73.73.92.01.9-1.9-1.91.9-1.9-1.91.9
Intermittent access intake escalation 21.01.71.81.11.3-1.3-1.31.3-1.3-1.31.3
Intermitt. access day 1 inactive lever presses0.00.00.0-0.00.1-0.1-0.10.1-0.1-0.10.2
Intermitt. access day 15 inactive lever presses0.00.00.10.30.2-0.2-0.20.2-0.2-0.20.2
Intermitt. access escalation Index0.00.00.1-0.0-0.20.20.2-0.20.20.2-0.3
Intermittent access day 1 total infusions0.00.00.00.0-0.00.00.0-0.00.00.0-0.0
Intermittent access day 15 total infusions1.02.53.01.71.6-1.6-1.61.6-1.6-1.61.5
Intermittent access terminal intake (last 3 days)0.81.41.51.01.2-1.2-1.21.2-1.2-1.21.2
Intermittent access total infusions1.21.41.51.11.2-1.2-1.21.2-1.2-1.21.2
Intermittent access day 1 locomotion0.00.00.20.40.1-0.1-0.10.1-0.0-0.0-0.0
Intermittent access day 15 total locomotion0.10.40.50.50.6-0.7-0.60.7-0.7-0.70.7
Intermittent access total locomotion0.10.10.10.40.4-0.4-0.30.4-0.4-0.40.3
Intermittent access standard deviation0.10.30.50.70.6-0.6-0.50.6-0.5-0.50.5
Left kidney weight0.00.20.4-0.0-0.40.40.4-0.50.40.4-0.6
Right kidney weight0.00.20.40.5-0.20.50.2-0.40.70.7-0.6
Cocaine induced anxiety0.00.10.50.70.10.10.0-0.10.20.2-0.4
Post-drug Anxiety0.91.12.71.61.1-0.9-1.00.9-0.9-0.90.7
Baseline Anxiety0.30.50.70.40.7-0.8-0.70.7-0.8-0.80.9
Tail length0.42.03.41.81.5-1.4-1.41.3-1.3-1.31.2
Length with tail0.10.30.50.2-0.30.50.4-0.50.60.6-0.7
Length without tail1.47.48.2-2.2-2.72.82.7-2.72.92.9-2.8
Times rat made contact with spout0.60.70.80.60.8-0.9-0.80.8-0.9-0.90.8
Lifetime Intake0.70.80.90.80.9-0.9-0.90.9-0.9-0.91.0
Liver weight, left1.52.63.8-1.1-1.61.61.7-1.81.51.5-2.0
Liver weight, right0.40.71.0-1.0-1.00.80.9-0.90.60.6-0.9
Locomotor activity1.62.54.7-0.2-1.41.61.7-1.71.61.6-2.2
Locomotor testing distance0.20.42.51.60.5-0.2-0.20.1-0.2-0.2-0.4
Locomotor testing rearing0.20.74.22.00.8-0.4-0.40.3-0.4-0.4-0.2
Locomotion in novel chamber0.50.60.91.00.8-0.8-0.70.8-0.8-0.80.7
Locomotion in novel chamber post-restriction0.41.21.3-1.1-1.11.11.1-1.11.11.1-1.0
Fecal boli incidents, locomotor time 10.51.31.6-0.9-1.11.21.1-1.21.21.2-1.3
Change in fecal boli incidents, locomotor task0.30.30.6-0.8-0.50.50.5-0.50.50.5-0.4
Time >=10cm from walls, locomotor time 10.91.11.31.21.1-1.1-1.01.1-1.0-1.01.0
Bouts of movement, locomotor time 14.05.26.2-2.5-2.32.32.4-2.32.22.2-2.1
Total resting periods, locomotor time 14.45.16.8-2.6-2.32.22.3-2.22.22.2-2.0
Rest time, locomotor task time 11.42.33.2-1.8-1.61.51.5-1.51.51.5-1.3
Distance moved, locomotor task time 11.23.43.51.91.9-1.9-1.71.9-1.9-1.91.8
Vertical activity count, locomotor time 10.21.12.41.51.1-1.0-1.01.0-0.9-0.90.8
Time >=10cm from walls, locomotor time 20.20.50.6-0.8-0.70.70.7-0.70.70.7-0.7
Bouts of movement, locomotor time 21.55.16.0-2.4-2.32.32.3-2.22.22.2-2.1
Total resting periods, locomotor time 21.45.66.7-2.6-2.42.42.4-2.32.32.3-2.2
Rest time, locomotor task time 20.81.32.5-1.6-1.21.11.1-1.11.01.0-0.9
Distance moved, locomotor task time 22.83.75.42.32.0-1.9-1.81.9-1.8-1.81.7
Vertical activity count, locomotor time 20.20.61.61.20.8-0.7-0.70.7-0.6-0.60.5
Light reinforcement 11.25.46.51.92.2-2.5-2.32.3-2.5-2.52.3
Light reinforcement 20.61.42.20.31.0-1.3-1.31.2-1.3-1.31.5
Bone: marrow area0.00.10.10.1-0.20.30.2-0.30.40.4-0.4
Bone: maximum diameter0.40.71.0-0.7-0.80.90.8-0.81.01.0-0.8
Bone: maximum force0.30.50.7-0.3-0.60.80.7-0.70.90.9-0.8
Bone: maximum moment0.20.40.60.0-0.40.70.6-0.60.70.7-0.7
Mean time between licks in bursts0.53.24.11.81.7-1.9-1.71.6-2.0-2.01.5
Mean num. licks in bursts0.10.30.30.50.6-0.6-0.50.6-0.6-0.60.6
Cd content in liver1.11.21.5-0.7-1.01.21.1-1.11.21.2-1.2
Co content in liver5.16.07.2-2.7-2.52.52.4-2.32.52.5-2.2
Cu content in liver0.40.50.6-0.8-0.70.70.7-0.60.80.8-0.6
Fe content in liver1.41.72.01.41.4-1.3-1.41.4-1.1-1.11.3
K content in liver1.11.01.30.91.0-1.0-1.11.1-1.0-1.01.1
Mg content in liver2.42.72.81.51.6-1.7-1.71.7-1.6-1.61.7
Mn content in liver2.42.73.21.81.7-1.6-1.71.7-1.6-1.61.6
Na content in liver0.91.01.7-0.2-0.81.11.0-1.11.11.1-1.3
Rb content in liver0.00.00.1-0.20.1-0.1-0.10.2-0.0-0.00.3
Se content in liver1.21.43.92.01.2-1.1-1.01.0-1.0-1.00.6
Sr content in liver0.00.00.10.30.2-0.1-0.20.10.00.00.1
Zn content in liver0.20.20.60.80.5-0.3-0.40.4-0.2-0.20.2
Bone: minimum diameter0.20.30.50.1-0.40.60.5-0.50.70.7-0.7
Time in familiar zone, hab. session 10.00.00.1-0.4-0.20.20.2-0.10.20.2-0.1
Time in novel zone, hab. session 11.11.21.7-1.3-1.11.11.1-1.11.11.1-0.9
Total zone transitions, hab. session 10.10.20.4-0.0-0.40.40.5-0.50.40.4-0.6
Total locomotion distance, hab. session 10.00.10.40.70.2-0.1-0.10.0-0.1-0.1-0.2
Locomotion velocity, hab. session 10.20.31.41.20.5-0.4-0.40.3-0.4-0.40.0
Time in familiar zone, hab. session 22.02.34.2-2.0-1.61.51.5-1.41.41.4-1.1
Time in novel zone, hab. session 20.70.81.51.20.9-0.8-0.90.8-0.8-0.80.7
Total zone transitions, hab. session 21.11.52.5-0.6-1.21.21.3-1.41.11.1-1.6
Total locomotion distance, hab. session 20.20.20.6-0.0-0.40.50.5-0.60.40.4-0.7
Locomotion velocity, hab. session 20.50.61.2-0.2-0.70.80.8-0.90.70.7-1.1
Novel to familiar place preference ratio1.31.72.31.51.3-1.3-1.31.2-1.3-1.31.1
Novelty place preference1.01.31.91.41.2-1.1-1.21.1-1.1-1.11.0
Time in novel zone, NPP test0.60.71.11.00.9-0.8-0.90.8-0.8-0.80.7
Total zone transitions, NPP test0.30.41.11.00.6-0.6-0.50.4-0.6-0.60.2
Total locomotion distance, NPP test2.84.06.32.52.0-2.0-1.91.8-2.0-2.01.6
Locomotion velocity, NPP test2.73.96.22.52.0-2.0-1.91.8-2.0-2.01.6
Intraocular pressure0.61.01.51.00.9-1.1-0.90.8-1.2-1.20.8
Delta distance traveled before/after self-admin3.03.36.1-2.5-1.91.71.8-1.71.61.6-1.4
Delta ambulatory time before/after self-admin2.03.56.0-2.4-2.01.81.9-1.81.71.7-1.5
Parametrial fat weight1.74.04.52.02.1-2.0-2.12.0-1.9-1.92.0
Pavlov. Cond. lever latency0.00.00.1-0.4-0.10.0-0.00.00.10.10.2
Pavlov. Cond. magazine entry latency0.00.00.00.20.2-0.2-0.20.2-0.2-0.20.2
Pavlov. Cond. change in total contacts0.91.01.5-0.7-1.01.01.1-1.10.90.9-1.2
Pavlov. Cond. index score0.10.10.10.0-0.20.20.3-0.30.20.2-0.4
Pavlov. Cond. latency score0.00.00.10.2-0.10.10.2-0.20.10.1-0.3
Pavlov. Cond. lever contacts0.00.00.20.40.2-0.2-0.10.1-0.2-0.2-0.0
Pavlov. Cond. magazine entry number0.30.40.50.50.7-0.6-0.70.7-0.6-0.60.7
Pavlov. Cond. intertrial magazine entries0.10.20.70.80.4-0.3-0.40.3-0.2-0.20.1
Pavlov. Cond. lever-magazine prob. diff.0.10.20.3-0.2-0.40.40.5-0.50.40.4-0.6
Pavlov. Cond. response bias0.10.10.2-0.3-0.40.40.5-0.40.30.3-0.5
Pavlov. Cond. lever latency0.30.41.00.00.6-0.6-0.70.8-0.6-0.61.0
Pavlov. Cond. magazine entry latency0.10.20.60.80.4-0.3-0.30.3-0.3-0.30.1
Pavlov. Cond. change in total contacts0.71.62.3-0.9-1.31.31.3-1.41.21.2-1.5
Pavlov. Cond. index score0.30.40.9-0.0-0.60.60.6-0.70.60.6-1.0
Pavlov. Cond. latency score0.20.30.70.1-0.40.50.5-0.60.40.4-0.8
Pavlov. Cond. lever contacts0.10.20.60.2-0.30.40.4-0.50.30.3-0.8
Pavlov. Cond. magazine entry number0.10.10.3-0.5-0.30.20.2-0.10.30.3-0.0
Pavlov. Cond. intertrial magazine entries3.67.88.22.82.8-2.9-2.82.8-2.9-2.92.7
Pavlov. Cond. lever-magazine prob. diff.0.30.51.0-0.2-0.70.70.7-0.80.60.6-1.0
Pavlov. Cond. response bias0.20.20.70.2-0.40.40.5-0.60.40.4-0.8
Time in closed arm before self-admin1.22.13.0-1.7-1.51.41.4-1.41.41.4-1.3
Time in closed arm after self-admin0.00.00.0-0.2-0.20.20.2-0.20.20.2-0.2
Time in open arm before self-admin0.00.00.10.30.1-0.0-0.00.00.00.0-0.1
Time in open arm after self-admin0.10.10.20.40.3-0.2-0.20.2-0.2-0.20.1
Bone: periosteal estimation0.10.10.20.1-0.20.40.3-0.30.50.5-0.4
Bone: periosteal perimeter0.00.10.20.1-0.20.30.2-0.30.40.4-0.4
Bone: post-yield work0.10.20.30.10.4-0.5-0.40.5-0.5-0.50.6
Progressive ratio test 1 active lever presses0.10.10.6-0.7-0.40.30.3-0.30.20.2-0.1
Progressive ratio test 1 breakpoint0.10.20.7-0.9-0.50.40.4-0.40.30.3-0.2
Progressive ratio test 1 inactive lever presses0.41.21.40.81.0-1.1-1.11.1-1.1-1.11.2
Progressive ratio test 2 active lever presses0.00.00.1-0.10.1-0.2-0.20.2-0.2-0.20.3
Progressive ratio test 2 breakpoint0.00.00.1-0.10.1-0.2-0.10.2-0.2-0.20.2
Progressive ratio test 2 inactive lever presses0.10.40.40.60.6-0.7-0.60.7-0.7-0.70.7
Incentive Sensitization - Responses0.10.30.40.60.6-0.6-0.60.6-0.6-0.60.5
Incentive Sensitization - Breakpoint0.20.50.60.80.7-0.7-0.70.7-0.7-0.70.6
Sum of active levers in priming session hrs 5-60.10.10.20.00.3-0.4-0.30.4-0.4-0.40.5
Progressive ratio0.00.00.1-0.2-0.10.10.1-0.10.10.1-0.0
Food seeking constrained by brief footshock2.32.97.3-2.7-1.81.61.6-1.51.41.4-1.1
Seeking ratio, punishment vs. effort0.51.12.2-1.5-1.11.01.0-1.00.90.9-0.8
Retroperitoneal fat weight0.10.30.60.40.6-0.5-0.70.7-0.3-0.30.7
Reaction time number correct0.30.91.6-1.3-1.10.91.0-1.00.80.8-0.9
Reaction time mean minus median0.00.20.3-0.0-0.30.40.3-0.40.50.5-0.5
Reaction time mean minus median AUC0.00.10.1-0.1-0.20.30.2-0.30.30.3-0.4
Reaction time num false alarms0.10.10.2-0.2-0.40.30.4-0.40.10.1-0.5
Reaction time num false alarms AUC0.00.10.2-0.2-0.30.10.4-0.3-0.0-0.0-0.4
Reaction time trials correct on left0.30.91.6-1.3-1.10.91.0-1.00.80.8-0.9
Reaction time trials on left0.20.71.3-1.2-0.90.80.8-0.90.60.6-0.8
Reaction time mean0.10.20.3-0.3-0.40.40.5-0.40.30.3-0.5
Reaction time mean AUC0.10.40.5-0.4-0.60.60.7-0.70.50.5-0.7
Median of all reaction times0.10.10.2-0.3-0.40.30.4-0.40.20.2-0.4
Reaction time omissions1.62.73.01.51.6-1.7-1.61.6-1.7-1.71.6
Reaction time false alarm rate0.10.10.20.40.3-0.3-0.20.2-0.4-0.40.2
Reaction time premature initiation rate1.62.54.0-2.0-1.71.51.8-1.61.31.3-1.4
Reaction time premature initiations1.23.66.3-2.5-2.11.82.1-1.91.51.5-1.7
Std. dev. reaction times0.00.10.2-0.1-0.30.30.3-0.40.30.3-0.5
Reaction time trials completed0.20.71.3-1.2-0.90.80.8-0.90.60.6-0.8
Reaction time trials AUC0.20.61.2-1.1-0.90.70.8-0.80.60.6-0.7
Run reversals in cocaine runway, females2.93.23.51.91.8-1.8-1.81.8-1.8-1.81.7
Run reversals in cocaine runway, males1.82.02.1-1.3-1.41.41.4-1.41.41.4-1.4
Latency to leave start box in cocaine runway0.40.50.6-0.7-0.70.70.7-0.70.70.7-0.7
Latency to leave start box in cocaine runway, F1.31.61.6-1.2-1.31.31.2-1.31.31.3-1.3
Latency to leave start box in cocaine runway, M0.10.10.10.30.3-0.3-0.30.3-0.3-0.30.2
Std. dev. time between licks in bursts1.22.34.32.11.4-1.5-1.31.2-1.7-1.70.9
Total sessions with >9 infusions0.00.00.1-0.3-0.20.20.2-0.20.20.2-0.2
Short access day 1 total inactive lever presses0.10.20.50.70.4-0.4-0.40.3-0.3-0.30.2
Short access day 10 total inactive lever presses0.00.20.20.40.5-0.5-0.50.5-0.5-0.50.5
Short access day 1 total infusions0.00.10.3-0.5-0.30.20.3-0.20.20.2-0.1
Short access day 10 total infusions0.20.40.5-0.3-0.60.60.6-0.60.70.7-0.7
Short access total infusions0.00.00.1-0.2-0.20.20.2-0.20.20.2-0.2
Short access day 1 locomotion0.61.01.3-0.7-1.01.11.0-1.01.11.1-1.1
Short access day 10 total locomotion0.00.00.10.30.10.0-0.1-0.00.00.0-0.1
Short access total locomotion0.10.20.30.1-0.30.40.4-0.40.40.4-0.6
One hour access (0.3 mA shock)0.70.81.31.10.9-0.9-0.90.8-0.8-0.80.7
Compulsive drug intake0.50.71.51.20.9-0.8-0.90.8-0.7-0.70.6
One hour access (shock baseline)0.00.00.00.10.0-0.00.00.0-0.0-0.0-0.0
Social response proportion0.20.31.2-1.1-0.50.40.4-0.30.50.50.0
Social responses0.91.21.60.91.1-1.0-1.21.2-0.9-0.91.3
Social time0.30.41.31.10.7-0.5-0.50.6-0.5-0.50.4
Soleus weight1.23.44.5-2.1-2.01.81.9-1.91.61.6-1.8
Bone: stiffness0.71.21.5-0.9-1.01.21.1-1.01.21.2-1.1
Tibialis anterior weight8.027.628.8-4.9-5.35.45.3-5.35.35.3-5.3
Time to tail flick, vehicle, before self-admin0.91.11.10.91.0-1.1-1.11.0-1.0-1.01.1
Time to tail flick, vehicle, after self-admin1.02.03.9-2.0-1.51.31.4-1.31.31.3-1.1
Time to tail flick, test, before self-admin2.73.14.12.01.8-1.8-1.81.7-1.7-1.71.6
Time to tail flick, test, after self-admin2.32.43.20.91.4-1.6-1.51.6-1.6-1.61.8
Delta time to tail flick, vehicle, before/after SA0.30.41.0-1.0-0.60.50.6-0.50.50.5-0.3
Delta time to tail flick, test, before/after SA0.10.10.6-0.8-0.1-0.2-0.10.2-0.2-0.20.4
Tibia length1.33.58.93.02.0-1.7-1.81.7-1.5-1.51.3
Ambulatory time before self-admin0.10.30.6-0.1-0.50.60.6-0.60.60.6-0.8
Ambulatory time after self-admin3.96.26.4-2.5-2.52.52.5-2.52.52.5-2.4
Bone: tissue strength0.00.00.10.30.2-0.1-0.20.2-0.0-0.00.1
Total heroin consumption0.60.70.8-0.6-0.80.90.8-0.80.80.8-0.9
Bone: trabecular number1.83.53.92.01.9-1.9-1.91.9-1.8-1.81.8
Bone: trabecular spacing2.13.03.2-1.8-1.81.81.7-1.71.81.8-1.7
Bone: trabecular thickness1.11.52.01.41.2-1.2-1.21.2-1.2-1.21.1
Bone: trabecular tissue density1.11.92.1-1.1-1.31.41.4-1.41.41.4-1.4
Water consumed over 24 hours0.81.61.8-1.1-1.31.31.3-1.31.31.3-1.3
Number of responses in last shaping day0.50.60.7-0.7-0.80.80.8-0.80.80.8-0.8