Hub : Genes

RGD1559600

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr1_173974388_173985543	0.5	0.3	1.1e-04	0.02	0.01	0.01	0.02	1.1e-03	1.3e-02	1.2e-02	5.2e-03
2	Liver	intron excision ratio	chr1_173974388_173987413	0.39	0.33	3.3e-03	0	-0	0	0.01	1.1e-01	7.8e-01	2.9e-01	5.8e-02
3	Adipose	gene expression	RGD1559600	0.24	0.1	0.0e+00	0.16	0.18	0.17	0.17	1.3e-17	2.4e-19	7.1e-19	8.9e-19
4	Brain	gene expression	RGD1559600	0.05	0.04	5.4e-03	0.01	0.01	0.02	0.01	4.7e-02	3.2e-02	1.2e-02	3.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.1	1.7	-1.3	-1.2	1.1	-0.0
Area under the delay curve	0.1	0.1	0.1	0.4	0.2	-0.3	0.2
BMI with tail	1.7	5.4	8.4	-2.9	-2.6	2.6	0.1
BMI without tail	5.5	11.4	18.2	-4.3	-3.9	3.4	0.9
Body weight	1.6	6.8	10.7	-3.3	-3.1	2.2	1.3
Weight adjusted by age	0.1	0.2	0.4	-0.1	-0.2	0.4	-0.7
Bone surface	0.8	1.4	3.0	-1.3	-1.7	0.5	0.8
Bone volume	1.2	2.0	3.5	-1.7	-1.9	1.2	0.4
Breakpoint value in progressive ratio session	0.6	0.7	1.7	0.6	1.3	-0.7	0.2
Number of licking bursts	4.2	5.0	8.1	2.9	2.5	-2.3	-0.3
Context. condit. distance diff. score	0.4	0.5	1.2	1.1	0.6	-0.6	-0.5
Locomotion velocity, session 1	0.1	0.1	0.4	0.0	-0.6	0.1	-0.1
Locomotion distance, session 1	0.5	0.7	1.3	-0.8	-1.1	0.9	-0.2
Locomotion velocity, session 2	0.0	0.0	0.0	0.2	-0.1	-0.2	0.0
Locomotion distance, session 2	1.4	1.9	3.4	-1.6	-1.8	1.2	0.5
Locomotion velocity, session 3	0.3	0.4	1.0	-0.5	-1.0	0.4	0.4
Locomotion distance, session 3	0.8	0.9	1.9	-0.3	-1.2	-0.3	1.4
Stereotopy head waving bouts, day 3	0.4	0.4	1.0	0.6	1.0	-0.5	-0.3
Stereotopy head waving duration, day 3	0.2	0.3	0.7	0.4	0.8	-0.2	-0.4
Locomotion velocity, session 7	2.2	2.5	5.4	-0.7	-2.3	-0.3	2.0
Locomotion distance, session 7	0.6	0.8	1.2	0.8	-0.6	-1.0	1.1
Stereotopy head waving bouts, day 7	0.5	0.6	1.3	-1.1	-0.6	0.6	0.6
Stereotopy head waving duration, day 7	1.8	2.2	4.1	-2.0	-1.6	1.3	0.8
Locomotion velocity, session 8	0.1	0.1	0.2	-0.1	-0.5	0.0	0.4
Locomotion distance, session 8	0.1	0.2	0.6	-0.0	-0.8	0.3	-0.1
Degree of sensitization distance	1.2	1.2	2.3	0.9	1.2	0.1	-1.5
Degree of sensitization stereotypy	2.2	2.4	4.2	-2.1	-1.7	1.1	1.2
Conditioned locomotion	1.1	1.3	3.7	0.1	-0.3	-1.1	1.9
Cocaine response after cond. corrected	0.2	0.2	0.4	0.6	0.4	-0.3	-0.3
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.0	-0.4	0.0	0.2
Cocaine response before conditioning	2.0	2.4	4.1	-1.7	-2.0	0.6	1.5
Saline control response	0.2	0.3	0.8	0.3	0.9	0.1	-0.6
Bone: connectivity density	0.3	0.5	1.0	-0.8	-1.0	0.6	0.2
Bone: cortical apparent density	0.5	0.7	1.3	1.0	1.1	-0.6	-0.3
Bone: cortical area	2.6	4.0	6.5	-2.6	-2.4	1.8	0.8
Bone: cortical porosity	0.7	0.8	1.3	-1.1	-1.1	0.5	0.7
Bone: cortical porosity	0.2	0.3	0.4	-0.5	-0.6	0.1	0.6
Bone: cortical thickness	1.2	2.0	3.5	-1.9	-1.5	1.6	0.2
Bone: cortical thickness	0.3	0.3	0.8	-0.7	-0.2	0.9	-0.3
Bone: cortical tissue density	0.5	0.7	1.3	1.0	1.1	-0.6	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.4	0.5	-0.3	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.1	0.1	-0.2	0.3
Condit. Reinf. active responses	0.3	0.4	0.6	0.5	0.7	0.0	-0.8
Condit. Reinf. inactive responses	0.5	0.6	1.6	0.5	0.7	0.4	-1.3
Incentive salience index mean	0.0	0.0	0.1	0.1	-0.2	-0.3	0.2
Condit. Reinf. lever presses	0.2	0.2	0.5	0.5	-0.1	-0.7	0.4
Condit. Reinf. active minus inactive responses	1.0	1.2	2.9	-0.2	0.2	1.3	-1.7
Condit. Reinf. active-inactive response ratio	1.6	1.7	4.6	0.5	1.0	0.9	-2.2
Condit. Reinf. active responses	0.4	0.5	1.0	-0.4	-0.2	1.0	-1.0
Condit. Reinf. inactive responses	1.4	1.8	3.0	-1.2	-1.7	0.1	1.6
Condit. Reinf. lever presses	0.8	1.1	1.6	-1.3	-1.0	1.3	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	-0.1	0.2	0.7	-0.9
Conditioned reinforcement - actives	0.6	0.6	1.5	-1.2	-0.3	0.9	0.2
Conditioned reinforcement - inactives	0.2	0.3	0.7	-0.3	0.8	0.4	-0.2
Conditioned locomotion	0.5	0.6	1.8	-0.4	0.1	-0.5	1.4
Patch foraging indifference point 0 sec	0.6	1.0	1.7	-1.3	-0.2	1.3	-0.8
Patch foraging indifference point AUC	1.2	1.4	2.5	-0.8	-0.2	1.6	-1.5
Delay disc. indifference point, 0s delay	0.8	0.9	1.3	-0.9	-1.1	0.4	1.2
Delay disc. indifference point, 16s delay	3.2	3.3	5.7	2.1	2.4	-1.4	-0.9
Delay disc. indifference point, 2s delay	2.8	3.2	5.6	-2.0	-2.4	1.6	0.6
Delay disc. indifference point, 24s delay	2.0	1.9	2.9	1.6	1.7	-1.4	-0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.1	-0.1	0.5	-0.4
Delay disc. indifference point, 8s delay	0.3	0.3	0.9	-0.3	-0.5	-0.2	0.9
Indifference point function ln k	0.6	0.8	1.4	-1.2	-0.8	0.5	0.9
Indifference point function log k	0.6	0.8	1.4	-1.2	-0.8	0.5	0.9
Patch foraging total patch changes 0 sec	0.9	1.4	2.4	-1.5	-0.1	1.5	-1.0
Patch foraging total patch changes 12 sec	0.2	0.3	0.5	-0.6	-0.1	0.7	-0.6
Patch foraging total patch changes 18 sec	0.3	0.3	0.9	-0.1	0.6	0.4	-0.9
Patch foraging total patch changes 24 sec	0.8	1.0	1.5	-0.9	-0.3	1.2	-1.2
Patch foraging total patch changes 6 sec	1.9	2.9	7.3	-0.0	1.5	1.4	-2.7
Patch foraging time to switch 0 sec	2.8	4.3	8.8	2.1	0.6	-3.0	1.9
Patch foraging water rate 0 sec	0.2	0.3	0.6	-0.7	-0.2	0.8	-0.2
Patch foraging water rate 12 sec	0.8	1.2	2.4	-1.3	-0.6	1.6	-0.5
Patch foraging water rate 18 sec	0.1	0.2	0.5	-0.4	-0.3	0.7	-0.1
Patch foraging water rate 24 sec	0.2	0.3	0.5	-0.5	-0.5	0.7	-0.0
Patch foraging water rate 6 sec	0.7	1.0	2.2	-0.3	0.7	1.2	-1.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.2	-0.0	-0.1	-0.6
Distance traveled before self-admin	0.1	0.1	0.2	-0.3	-0.5	0.2	0.1
Distance traveled after self-admin	0.7	0.8	2.0	-0.8	-1.4	0.7	0.0
Extensor digitorum longus weight	3.9	15.3	26.9	-4.5	-5.2	1.9	3.2
Bone: elastic displacement	0.4	0.4	0.8	0.4	0.9	-0.0	-0.8
Bone: elastic work	0.3	0.3	0.5	-0.7	-0.7	0.6	-0.2
Bone: endosteal estimation	1.2	2.5	4.5	-1.8	-2.1	0.9	1.1
Bone: endosteal perimeter	0.8	1.7	3.2	-1.3	-1.8	0.3	1.3
Epididymis fat weight	0.7	1.6	3.1	-1.5	-0.7	1.7	-0.7
Delta time in closed arm before/after self-admin	0.8	0.8	1.7	0.5	-0.1	-1.1	1.3
Delta time in open arm before/after self-admin	2.9	2.8	5.7	-1.5	-0.7	2.4	-1.7
Diff in mean of infusions in LGA sessions	1.9	2.1	5.4	0.4	1.4	0.9	-2.3
Delay discount exponential model param	0.1	0.1	0.2	-0.5	-0.2	0.4	-0.2
Extinction: sum of active levers before priming	0.3	0.3	0.5	0.7	0.7	-0.3	-0.5
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.2	0.6	0.4	-0.5
Bone: final force	4.5	7.2	12.0	-3.5	-3.0	2.8	0.5
Bone: final moment	3.8	6.1	10.1	-3.2	-2.7	2.6	0.3
Food consumed during 24 hour testing period	1.5	1.8	3.0	-1.7	-1.3	1.6	-0.2
Glucose	0.3	0.4	0.8	-0.4	0.3	0.8	-0.9
Heart weight	0.7	1.0	2.0	-0.1	0.9	1.1	-1.4
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2
Intermittent access intake day 1-15 change	0.2	0.2	0.5	0.4	0.7	-0.3	0.4
Intermittent access intake escalation	0.2	0.2	0.4	0.4	0.6	-0.2	0.1
Intermittent access intake escalation 2	0.5	0.5	1.1	1.0	0.8	-0.4	-0.3
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	0.2	0.6	-0.0	0.3
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.5	-1.2	-1.1	0.6	1.2
Intermitt. access escalation Index	1.2	1.1	2.3	-1.0	-0.6	1.5	-0.9
Intermittent access day 1 total infusions	0.8	0.9	1.8	-1.3	-1.0	0.8	0.5
Intermittent access day 15 total infusions	0.3	0.3	0.6	-0.8	-0.1	0.7	0.2
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	-0.8	-0.0	0.8	0.1
Intermittent access total infusions	1.1	1.2	2.6	-1.6	-0.8	1.2	0.6
Intermittent access day 1 locomotion	0.9	0.9	1.7	-1.1	-0.4	1.3	-0.7
Intermittent access day 15 total locomotion	1.7	1.8	3.6	-0.1	1.9	1.0	-1.6
Intermittent access total locomotion	1.6	1.8	3.7	-1.2	0.4	1.9	-1.4
Intermittent access standard deviation	0.2	0.2	0.4	-0.3	-0.4	0.6	0.1
Left kidney weight	3.1	8.7	13.8	-3.7	-3.3	3.1	0.6
Right kidney weight	3.1	8.7	13.5	-3.7	-3.5	2.9	0.7
Cocaine induced anxiety	0.9	1.0	2.9	0.6	0.8	0.5	-1.7
Post-drug Anxiety	1.3	1.4	3.8	0.9	0.9	0.4	-2.0
Baseline Anxiety	0.3	0.3	0.6	-0.6	-0.8	0.3	0.2
Tail length	1.9	5.8	9.0	-3.0	-2.9	2.1	1.1
Length with tail	0.4	1.5	2.6	-1.3	-1.6	0.6	1.1
Length without tail	0.6	1.2	2.5	1.2	0.7	-1.6	0.7
Times rat made contact with spout	1.6	1.8	2.7	-1.5	-1.7	0.7	1.3
Lifetime Intake	1.7	1.9	3.8	-2.0	-1.2	1.4	0.8
Liver weight, left	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.1
Liver weight, right	0.2	0.4	0.9	-0.3	-0.8	-0.1	0.9
Locomotor activity	0.0	0.0	0.1	0.2	0.2	-0.2	0.3
Locomotor testing distance	0.1	0.2	0.4	-0.5	0.1	0.7	-0.4
Locomotor testing rearing	0.1	0.1	0.3	0.5	0.5	-0.2	-0.2
Locomotion in novel chamber	1.0	1.2	2.3	-0.8	-0.1	1.3	-1.5
Locomotion in novel chamber post-restriction	1.9	2.3	5.4	1.0	1.7	0.5	-2.3
Fecal boli incidents, locomotor time 1	0.8	0.8	1.9	0.7	0.1	-1.4	1.0
Change in fecal boli incidents, locomotor task	0.9	0.8	1.6	-0.7	-0.1	1.3	-1.1
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.9	-1.4	-1.1	0.9	0.5
Bouts of movement, locomotor time 1	2.7	2.9	4.6	2.1	2.0	-1.1	-1.3
Total resting periods, locomotor time 1	2.8	3.1	5.4	2.3	2.0	-1.6	-0.7
Rest time, locomotor task time 1	2.0	2.2	4.8	1.5	0.2	-2.2	1.4
Distance moved, locomotor task time 1	2.5	2.7	5.7	-1.7	-0.3	2.4	-1.4
Vertical activity count, locomotor time 1	3.9	4.1	8.6	-2.2	-0.7	2.9	-1.6
Time >=10cm from walls, locomotor time 2	3.0	3.2	5.0	-2.2	-2.0	1.0	1.6
Bouts of movement, locomotor time 2	0.4	0.4	0.9	-0.1	-0.8	-0.4	1.0
Total resting periods, locomotor time 2	0.6	0.6	1.1	-0.3	-1.1	-0.4	1.0
Rest time, locomotor task time 2	0.0	0.1	0.1	-0.0	-0.3	-0.2	0.3
Distance moved, locomotor task time 2	0.4	0.5	0.9	-1.0	-0.5	0.9	-0.0
Vertical activity count, locomotor time 2	0.9	1.0	2.1	-1.0	-0.1	1.5	-0.8
Light reinforcement 1	0.1	0.3	0.5	0.4	0.7	0.0	-0.6
Light reinforcement 2	0.1	0.2	0.3	-0.2	0.5	0.5	-0.5
Bone: marrow area	1.0	2.2	3.9	-1.7	-2.0	0.8	1.1
Bone: maximum diameter	1.4	2.6	4.2	-2.0	-1.9	1.4	0.6
Bone: maximum force	3.6	6.2	9.9	-3.2	-3.0	2.4	0.4
Bone: maximum moment	3.0	5.1	8.3	-2.9	-2.6	2.3	0.3
Mean time between licks in bursts	0.0	0.0	0.1	0.1	0.2	-0.1	-0.0
Mean num. licks in bursts	6.2	7.5	12.2	-3.5	-3.2	2.6	1.0
Cd content in liver	3.6	4.0	7.4	2.3	2.7	-1.4	-1.2
Co content in liver	1.0	1.2	2.4	0.7	1.4	0.4	-1.6
Cu content in liver	0.9	1.1	2.0	-0.5	0.1	1.4	-1.4
Fe content in liver	1.0	1.2	2.0	1.2	1.2	0.1	-1.4
K content in liver	0.2	0.2	0.3	-0.2	0.3	0.5	-0.6
Mg content in liver	0.1	0.1	0.3	0.3	0.6	-0.2	-0.0
Mn content in liver	0.3	0.3	0.7	-0.5	-0.6	-0.2	0.8
Na content in liver	3.7	4.0	7.1	-2.2	-2.7	0.9	1.7
Rb content in liver	1.8	2.3	4.7	0.6	1.8	0.8	-2.2
Se content in liver	0.1	0.1	0.3	-0.2	-0.3	0.6	-0.4
Sr content in liver	0.4	0.3	0.6	-0.8	-0.6	0.5	0.4
Zn content in liver	1.8	2.0	3.4	-1.9	-1.7	1.3	0.4
Bone: minimum diameter	1.7	3.2	5.6	-2.1	-2.4	1.0	1.2
Time in familiar zone, hab. session 1	1.6	1.5	3.5	0.6	1.3	0.6	-1.9
Time in novel zone, hab. session 1	3.8	3.7	9.5	-0.8	-1.9	-1.0	3.1
Total zone transitions, hab. session 1	2.5	3.5	5.4	-2.1	-1.9	2.3	-0.6
Total locomotion distance, hab. session 1	4.5	6.3	9.5	-3.0	-2.5	3.1	-0.8
Locomotion velocity, hab. session 1	3.7	5.3	9.0	-2.5	-1.9	3.0	-1.4
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.6	-0.3	0.8	-0.4
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.1	-0.2	-0.1
Total zone transitions, hab. session 2	2.0	2.6	3.8	-1.9	-1.6	1.9	-0.6
Total locomotion distance, hab. session 2	2.5	3.2	4.7	-2.1	-1.8	2.2	-0.8
Locomotion velocity, hab. session 2	2.9	3.9	5.4	-2.3	-2.0	2.3	-0.7
Novel to familiar place preference ratio	0.8	0.8	1.8	0.6	1.4	-0.2	-1.0
Novelty place preference	0.7	0.7	1.6	0.7	1.3	-0.2	-0.9
Time in novel zone, NPP test	0.8	0.8	1.7	0.6	1.3	-0.1	-1.0
Total zone transitions, NPP test	1.5	2.1	3.2	-1.8	-1.5	1.7	0.1
Total locomotion distance, NPP test	1.4	1.9	3.3	-1.6	-1.2	1.8	-0.7
Locomotion velocity, NPP test	1.1	1.5	2.6	-1.4	-1.1	1.6	-0.6
Intraocular pressure	0.1	0.1	0.3	-0.2	-0.6	-0.1	0.4
Delta distance traveled before/after self-admin	0.7	0.7	1.5	-0.9	-1.2	0.6	0.4
Delta ambulatory time before/after self-admin	0.6	0.7	1.5	-0.9	-1.2	0.6	0.3
Parametrial fat weight	2.7	5.3	9.7	-2.6	-1.8	3.1	-1.1
Pavlov. Cond. lever latency	0.8	1.0	1.9	0.2	1.2	0.6	-1.4
Pavlov. Cond. magazine entry latency	1.2	1.5	3.4	-1.1	-1.8	0.1	1.3
Pavlov. Cond. change in total contacts	2.0	2.1	5.0	0.0	-1.4	-1.2	2.2
Pavlov. Cond. index score	1.0	1.2	2.4	-0.4	-1.4	-0.6	1.6
Pavlov. Cond. latency score	0.7	0.9	1.8	-0.4	-1.3	-0.4	1.3
Pavlov. Cond. lever contacts	1.3	1.5	2.9	-0.4	-1.6	-0.6	1.7
Pavlov. Cond. magazine entry number	1.4	1.7	3.7	0.4	1.5	0.8	-1.9
Pavlov. Cond. intertrial magazine entries	1.3	1.6	3.2	0.8	1.8	0.2	-1.6
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	2.5	-0.6	-1.6	-0.4	1.5
Pavlov. Cond. response bias	1.9	2.3	5.1	-0.4	-1.7	-1.0	2.3
Pavlov. Cond. lever latency	0.7	0.9	1.4	1.2	0.9	-1.2	0.2
Pavlov. Cond. magazine entry latency	1.5	1.7	3.4	1.5	0.6	-1.8	0.9
Pavlov. Cond. change in total contacts	0.6	0.8	2.1	0.1	0.8	0.8	-1.5
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	0.2	-0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	-0.0	-0.2	0.0
Pavlov. Cond. lever contacts	0.7	0.9	1.5	-1.2	-1.0	1.1	-0.0
Pavlov. Cond. magazine entry number	1.5	1.8	2.9	-1.7	-1.4	1.5	0.2
Pavlov. Cond. intertrial magazine entries	1.8	2.3	3.6	-1.9	-1.7	1.7	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.5	0.3	-0.4	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.3
Time in closed arm before self-admin	0.8	0.9	1.4	-1.2	-0.7	1.2	-0.5
Time in closed arm after self-admin	0.6	0.6	1.2	0.7	1.1	-0.3	-0.7
Time in open arm before self-admin	2.1	2.2	4.0	2.0	1.4	-1.7	0.1
Time in open arm after self-admin	0.7	0.8	1.4	-0.9	-0.9	1.2	-0.5
Bone: periosteal estimation	2.4	5.0	7.9	-2.8	-2.8	1.7	1.2
Bone: periosteal perimeter	1.2	2.0	3.5	-1.7	-1.9	1.0	0.7
Bone: post-yield work	1.5	2.0	3.5	-1.9	-1.5	1.6	0.0
Progressive ratio test 1 active lever presses	0.4	0.4	1.0	-1.0	-0.3	0.8	0.1
Progressive ratio test 1 breakpoint	0.3	0.4	0.8	-0.9	-0.3	0.7	0.2
Progressive ratio test 1 inactive lever presses	0.9	1.0	2.5	-1.6	-0.3	1.0	0.6
Progressive ratio test 2 active lever presses	0.5	0.6	1.1	-1.1	-0.4	0.3	1.0
Progressive ratio test 2 breakpoint	0.6	0.7	1.4	-1.2	-0.3	0.4	1.1
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.1	-1.0	0.3	0.5	0.7
Incentive Sensitization - Responses	1.3	1.3	3.9	-1.0	-0.3	-0.4	2.0
Incentive Sensitization - Breakpoint	1.3	1.3	4.0	-1.1	-0.3	-0.2	2.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.3	0.3	-0.3	-0.0
Progressive ratio	0.4	0.5	1.2	-0.0	0.7	0.4	-1.1
Food seeking constrained by brief footshock	1.1	1.3	2.5	1.3	1.6	-0.9	-0.6
Seeking ratio, punishment vs. effort	0.3	0.3	0.9	0.1	-0.5	-0.4	0.9
Retroperitoneal fat weight	0.5	1.5	2.9	-0.5	0.4	1.6	-1.7
Reaction time number correct	0.8	1.1	1.7	1.3	0.9	-1.3	0.4
Reaction time mean minus median	0.3	0.5	0.8	-0.6	0.1	0.9	-0.9
Reaction time mean minus median AUC	0.5	0.6	1.1	-0.4	0.6	0.9	-1.0
Reaction time num false alarms	0.9	1.2	1.8	1.3	1.3	-0.7	-0.9
Reaction time num false alarms AUC	0.6	0.9	1.5	1.2	1.0	-0.7	-0.7
Reaction time trials correct on left	0.8	1.1	1.7	1.3	0.9	-1.3	0.4
Reaction time trials on left	0.8	1.1	1.7	1.3	0.9	-1.3	0.4
Reaction time mean	0.4	0.5	0.9	-0.4	-0.3	0.9	-0.9
Reaction time mean AUC	0.1	0.2	0.3	-0.1	-0.2	0.5	-0.5
Median of all reaction times	0.2	0.3	0.5	-0.2	-0.4	0.7	-0.7
Reaction time omissions	0.2	0.3	0.7	0.7	0.2	-0.8	0.2
Reaction time false alarm rate	0.1	0.1	0.3	0.4	0.4	-0.1	-0.5
Reaction time premature initiation rate	1.6	2.1	3.5	-1.3	-1.8	-0.1	1.9
Reaction time premature initiations	1.3	1.8	4.7	-0.5	-1.2	-1.0	2.2
Std. dev. reaction times	0.4	0.6	1.0	-0.6	-0.2	1.0	-0.9
Reaction time trials completed	0.8	1.1	1.7	1.3	0.9	-1.3	0.4
Reaction time trials AUC	0.6	0.8	1.3	1.2	0.8	-1.1	0.4
Run reversals in cocaine runway, females	4.0	3.9	8.7	-2.1	-2.9	1.5	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.0	0.5	-0.4	0.3
Latency to leave start box in cocaine runway	0.4	0.5	0.9	-0.1	0.7	0.7	-1.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.3	0.4	-0.4	0.2
Latency to leave start box in cocaine runway, M	1.0	0.9	2.0	-0.3	0.7	1.1	-1.4
Std. dev. time between licks in bursts	0.2	0.2	0.5	-0.1	0.3	0.5	-0.7
Total sessions with >9 infusions	4.5	5.0	8.0	-2.8	-2.7	1.5	1.7
Short access day 1 total inactive lever presses	0.2	0.3	0.8	-0.5	-0.0	0.1	0.9
Short access day 10 total inactive lever presses	0.4	0.4	1.0	0.7	1.0	-0.4	0.1
Short access day 1 total infusions	1.1	1.2	1.9	-1.4	-1.1	0.7	1.1
Short access day 10 total infusions	2.1	2.3	4.1	-2.0	-1.6	0.8	1.4
Short access total infusions	2.5	2.8	5.4	-2.3	-1.6	1.5	1.0
Short access day 1 locomotion	0.3	0.4	0.6	-0.8	-0.5	0.1	0.8
Short access day 10 total locomotion	1.5	1.7	3.5	-1.4	-0.9	1.9	-0.8
Short access total locomotion	2.1	2.2	4.4	-1.8	-0.7	2.1	-0.9
One hour access (0.3 mA shock)	1.8	2.1	4.3	-1.6	-1.0	2.1	-0.8
Compulsive drug intake	0.1	0.1	0.1	-0.1	0.2	0.3	-0.3
One hour access (shock baseline)	0.3	0.3	0.8	0.0	0.4	0.7	-0.9
Social response proportion	0.7	0.8	1.8	0.2	1.0	0.5	-1.3
Social responses	0.6	0.8	1.9	0.7	1.4	-0.4	-0.8
Social time	0.6	0.7	1.6	0.9	1.3	-0.7	-0.5
Soleus weight	1.6	4.7	7.4	-2.7	-2.3	2.5	-0.1
Bone: stiffness	3.0	4.8	7.9	-2.8	-2.5	2.3	0.2
Tibialis anterior weight	5.3	18.3	30.8	-5.6	-5.1	3.7	1.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.2	-0.5	0.3	-0.2
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.0	1.0	0.5	-1.0	0.5
Time to tail flick, test, before self-admin	0.5	0.5	1.0	-0.8	-0.3	-0.0	1.0
Time to tail flick, test, after self-admin	0.3	0.3	0.6	0.8	0.3	-0.8	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.4	0.2	-0.3	0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.4	-0.1	-0.1	-0.3
Tibia length	0.2	0.4	1.1	0.2	0.6	0.5	-1.1
Ambulatory time before self-admin	0.0	0.0	0.1	-0.1	-0.0	0.1	-0.2
Ambulatory time after self-admin	0.8	0.9	2.9	-0.7	-1.7	0.5	0.2
Bone: tissue strength	0.1	0.1	0.2	-0.0	-0.4	-0.2	0.1
Total heroin consumption	0.3	0.3	0.6	0.6	0.8	-0.5	0.2
Bone: trabecular number	0.5	0.8	1.3	-1.1	-0.9	1.0	-0.2
Bone: trabecular spacing	0.7	0.9	1.5	1.0	0.8	-1.2	0.7
Bone: trabecular thickness	2.8	3.3	6.0	-1.7	-0.9	2.5	-1.9
Bone: trabecular tissue density	0.1	0.1	0.2	-0.2	0.1	0.4	-0.3
Water consumed over 24 hours	1.3	1.6	3.4	0.7	-0.3	-1.6	1.8
Number of responses in last shaping day	0.5	0.5	0.9	-0.5	-0.9	-0.1	0.9