Hub : Genes

Kank4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Kank4	0.21	0.16	2.2e-11	0.07	0.07	0.07	0.07	3.3e-08	8.6e-08	1.9e-08	5.9e-08
2	PL	gene expression	Kank4	0.31	1	2.4e-09	0.1	0.08	0.09	0.09	9.1e-11	1.6e-09	1.7e-10	2.3e-10
3	pVTA	gene expression	Kank4	0.09	0.09	1.9e-03	0.07	0.05	0.06	0.06	6.5e-04	2.8e-03	2.1e-03	2.0e-03
4	BLA	gene expression	Kank4	0.17	0.13	9.3e-09	0.07	0.15	0.12	0.12	1.2e-04	1.7e-08	5.7e-07	8.3e-07
5	NAcc	gene expression	Kank4	0.04	0.04	1.9e-05	0.04	0.04	0.04	0.04	1.4e-05	1.1e-05	2.3e-05	1.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.3	0.4	0.5	0.5	-0.5	-0.5
Area under the delay curve	0.5	0.6	0.7	0.7	0.8	0.7	-0.8	-0.7
BMI with tail	0.1	0.2	0.4	-0.2	-0.6	-0.5	0.4	0.4
BMI without tail	0.3	0.5	0.6	-0.7	-0.7	-0.7	0.7	0.7
Body weight	0.1	0.2	0.4	0.2	0.7	0.5	-0.5	-0.5
Weight adjusted by age	2.1	2.4	3.0	-1.3	-1.7	-1.5	1.6	1.6
Bone surface	2.2	3.9	4.0	-2.0	-1.9	-2.0	2.0	2.0
Bone volume	0.6	1.1	1.1	-1.0	-1.0	-1.1	1.0	1.0
Breakpoint value in progressive ratio session	0.2	0.2	0.5	0.3	0.7	0.3	-0.5	-0.5
Number of licking bursts	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.2	0.2
Context. condit. distance diff. score	2.9	3.5	3.6	1.8	1.9	1.9	-1.9	-1.9
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	0.3
Locomotion distance, session 1	0.6	0.8	0.9	0.8	1.0	0.9	-0.9	-0.9
Locomotion velocity, session 2	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	0.6
Locomotion distance, session 2	0.2	0.2	0.5	-0.7	-0.3	-0.5	0.4	0.4
Locomotion velocity, session 3	0.0	0.0	0.0	0.1	-0.0	0.0	-0.0	-0.0
Locomotion distance, session 3	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0
Stereotopy head waving bouts, day 3	0.4	0.5	0.5	0.7	0.7	0.7	-0.7	-0.7
Stereotopy head waving duration, day 3	0.7	0.9	0.9	0.9	0.9	0.9	-0.9	-0.9
Locomotion velocity, session 7	0.3	0.4	0.4	0.6	0.6	0.6	-0.6	-0.6
Locomotion distance, session 7	0.3	0.4	0.4	0.7	0.6	0.6	-0.6	-0.6
Stereotopy head waving bouts, day 7	1.2	1.3	1.5	-1.2	-1.1	-1.2	1.1	1.1
Stereotopy head waving duration, day 7	1.1	1.4	1.5	-1.2	-1.1	-1.2	1.2	1.2
Locomotion velocity, session 8	0.5	0.5	0.6	0.7	0.7	0.8	-0.7	-0.7
Locomotion distance, session 8	0.8	1.2	1.5	0.9	1.2	1.1	-1.1	-1.1
Degree of sensitization distance	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.2	0.2
Degree of sensitization stereotypy	1.3	1.4	1.5	-1.2	-1.2	-1.2	1.2	1.2
Conditioned locomotion	0.0	0.0	0.0	0.1	0.2	0.1	-0.1	-0.1
Cocaine response after cond. corrected	0.8	0.9	1.1	-1.0	-0.9	-0.9	0.9	0.9
Cocaine response after cond. not corrected	0.6	0.7	0.7	-0.9	-0.9	-0.8	0.8	0.8
Cocaine response before conditioning	0.0	0.0	0.0	0.1	0.0	0.1	-0.0	-0.0
Saline control response	0.1	0.2	0.3	0.4	0.5	0.4	-0.5	-0.4
Bone: connectivity density	1.8	2.8	2.8	-1.7	-1.7	-1.7	1.7	1.7
Bone: cortical apparent density	7.9	10.4	10.6	3.2	3.2	3.3	-3.2	-3.2
Bone: cortical area	0.1	0.2	0.3	-0.5	-0.3	-0.4	0.4	0.4
Bone: cortical porosity	0.4	0.5	0.5	-0.7	-0.6	-0.7	0.7	0.7
Bone: cortical porosity	0.6	0.7	0.8	-0.9	-0.7	-0.9	0.8	0.8
Bone: cortical thickness	0.3	0.5	0.5	0.6	0.7	0.7	-0.7	-0.7
Bone: cortical thickness	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.0	0.0
Bone: cortical tissue density	7.7	10.2	10.4	3.2	3.2	3.2	-3.2	-3.2
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.4	0.3	0.4	-0.3	-0.3
Condit. Reinf. active responses	0.3	0.4	0.5	-0.7	-0.4	-0.6	0.6	0.6
Condit. Reinf. inactive responses	0.3	0.3	0.5	-0.7	-0.4	-0.6	0.5	0.5
Incentive salience index mean	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	0.2
Condit. Reinf. lever presses	0.2	0.2	0.3	0.3	0.6	0.4	-0.5	-0.4
Condit. Reinf. active minus inactive responses	1.4	1.7	1.7	1.3	1.3	1.3	-1.3	-1.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.6	0.7	0.7	0.8	-0.7	-0.7
Condit. Reinf. active responses	1.1	1.5	1.5	1.2	1.2	1.2	-1.2	-1.2
Condit. Reinf. inactive responses	1.8	2.2	2.3	1.5	1.5	1.4	-1.5	-1.4
Condit. Reinf. lever presses	2.8	3.8	3.9	-1.9	-1.9	-2.0	2.0	2.0
Condit. Reinf. lever reinforcers received	0.4	0.6	0.6	0.8	0.8	0.8	-0.8	-0.7
Conditioned reinforcement - actives	0.3	0.3	0.5	0.3	0.7	0.5	-0.5	-0.5
Conditioned reinforcement - inactives	0.7	0.8	1.8	0.3	1.3	0.8	-0.9	-0.9
Conditioned locomotion	0.2	0.2	0.4	0.4	0.7	0.3	-0.5	-0.4
Patch foraging indifference point 0 sec	6.1	9.8	11.5	-3.1	-3.0	-3.4	3.1	3.1
Patch foraging indifference point AUC	0.9	1.0	1.6	-1.3	-0.8	-1.0	1.0	1.0
Delay disc. indifference point, 0s delay	2.7	2.9	3.3	1.8	1.6	1.7	-1.7	-1.7
Delay disc. indifference point, 16s delay	0.5	0.6	0.7	-0.9	-0.6	-0.8	0.7	0.7
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	0.8	0.4	0.6	-0.5	-0.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.4	0.5	0.4	-0.4	-0.4
Delay disc. indifference point, 4s delay	3.3	3.5	4.0	1.7	2.0	1.8	-1.9	-1.9
Delay disc. indifference point, 8s delay	2.0	2.0	2.5	1.3	1.6	1.4	-1.5	-1.4
Indifference point function ln k	0.2	0.2	0.5	0.7	0.3	0.4	-0.5	-0.5
Indifference point function log k	0.2	0.2	0.5	0.7	0.3	0.4	-0.5	-0.5
Patch foraging total patch changes 0 sec	5.6	9.0	10.8	-3.0	-2.8	-3.3	2.9	3.0
Patch foraging total patch changes 12 sec	0.8	1.0	1.5	-1.0	-0.9	-1.2	1.0	1.0
Patch foraging total patch changes 18 sec	1.8	2.4	3.1	-1.6	-1.3	-1.8	1.5	1.5
Patch foraging total patch changes 24 sec	1.7	2.1	2.7	-1.5	-1.4	-1.7	1.4	1.4
Patch foraging total patch changes 6 sec	2.1	3.1	3.6	-1.9	-1.6	-1.8	1.7	1.7
Patch foraging time to switch 0 sec	1.8	2.7	3.2	1.6	1.6	1.8	-1.6	-1.6
Patch foraging water rate 0 sec	1.8	2.9	3.2	-1.7	-1.6	-1.8	1.7	1.7
Patch foraging water rate 12 sec	3.7	5.6	6.3	-2.4	-2.2	-2.5	2.3	2.3
Patch foraging water rate 18 sec	0.2	0.2	0.3	-0.5	-0.4	-0.4	0.5	0.5
Patch foraging water rate 24 sec	0.0	0.1	0.1	-0.3	-0.1	-0.3	0.2	0.2
Patch foraging water rate 6 sec	0.3	0.4	0.5	-0.5	-0.7	-0.7	0.6	0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	-0.5	0.3	-0.2	-0.1	-0.1
Distance traveled before self-admin	0.0	0.0	0.1	-0.3	-0.0	0.0	0.1	0.1
Distance traveled after self-admin	0.7	0.8	2.0	-1.4	-0.3	-0.8	0.8	0.9
Extensor digitorum longus weight	0.6	2.5	2.6	1.6	1.6	1.6	-1.6	-1.6
Bone: elastic displacement	0.9	1.0	1.2	1.1	0.9	1.0	-1.0	-1.0
Bone: elastic work	1.3	1.7	1.8	1.3	1.3	1.2	-1.3	-1.3
Bone: endosteal estimation	0.7	1.5	1.6	-1.3	-1.2	-1.2	1.2	1.2
Bone: endosteal perimeter	1.4	2.9	3.2	-1.8	-1.6	-1.7	1.7	1.7
Epididymis fat weight	2.2	5.1	5.6	2.1	2.3	2.4	-2.3	-2.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.2	-0.7	-0.2	0.4	0.4
Delta time in open arm before/after self-admin	1.5	1.5	2.9	-1.7	-0.8	-1.3	1.0	1.1
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	0.2	0.7	0.5	-0.4	-0.4
Delay discount exponential model param	0.5	0.6	0.7	-0.7	-0.9	-0.7	0.8	0.7
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.4	0.5	0.3	-0.4	-0.4
Active lever presses in extinction session 6	0.0	0.0	0.1	0.0	0.3	0.1	-0.1	-0.1
Bone: final force	0.3	0.5	0.6	0.8	0.7	0.7	-0.7	-0.7
Bone: final moment	0.0	0.0	0.0	0.1	0.1	0.0	-0.1	-0.1
Food consumed during 24 hour testing period	0.2	0.3	0.3	0.5	0.6	0.5	-0.5	-0.5
Glucose	0.0	0.0	0.0	-0.0	-0.2	-0.2	0.2	0.2
Heart weight	3.1	4.4	4.9	2.2	2.0	2.2	-2.1	-2.1
Delay discount hyperbolic model param	0.7	0.7	0.8	-0.8	-0.9	-0.8	0.9	0.8
Intermittent access intake day 1-15 change	0.6	0.6	0.8	0.5	0.9	0.8	-0.8	-0.8
Intermittent access intake escalation	0.5	0.5	0.6	0.5	0.8	0.7	-0.7	-0.7
Intermittent access intake escalation 2	0.5	0.5	0.7	0.6	0.7	0.8	-0.7	-0.7
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.2	-1.5	-1.2	-1.2	1.1	1.2
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.6	0.5	1.3	0.7	-1.1	-1.0
Intermitt. access escalation Index	1.2	1.0	2.2	-0.3	-1.5	-0.9	1.0	1.0
Intermittent access day 1 total infusions	0.1	0.1	0.4	-0.1	0.6	0.2	-0.4	-0.4
Intermittent access day 15 total infusions	0.4	0.4	0.7	0.4	0.8	0.6	-0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	-0.2	0.6	0.2	-0.3	-0.3
Intermittent access total infusions	0.2	0.3	0.5	0.3	0.7	0.4	-0.6	-0.6
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.4	-0.2	-0.5	0.3	0.3
Intermittent access day 15 total locomotion	0.1	0.1	0.1	-0.3	0.1	-0.3	0.1	0.2
Intermittent access total locomotion	0.2	0.2	0.5	-0.7	-0.2	-0.5	0.4	0.4
Intermittent access standard deviation	1.2	1.2	1.5	1.2	1.0	1.1	-1.1	-1.1
Left kidney weight	0.3	1.0	1.3	0.8	1.1	1.0	-1.0	-1.0
Right kidney weight	0.2	0.6	0.9	0.5	1.0	0.9	-0.7	-0.7
Cocaine induced anxiety	0.1	0.1	0.2	0.3	0.3	0.3	-0.4	-0.4
Post-drug Anxiety	1.1	1.2	1.3	1.1	1.0	1.1	-1.1	-1.1
Baseline Anxiety	0.6	0.6	1.2	1.1	0.4	0.9	-0.6	-0.6
Tail length	0.4	1.3	2.4	0.6	1.5	1.1	-1.1	-1.1
Length with tail	0.4	1.4	2.6	0.6	1.6	1.2	-1.2	-1.1
Length without tail	0.1	0.1	0.3	0.0	0.5	0.3	-0.3	-0.3
Times rat made contact with spout	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1
Lifetime Intake	0.1	0.1	0.3	-0.0	0.5	0.1	-0.4	-0.3
Liver weight, left	2.1	3.3	3.7	1.8	1.9	1.7	-1.8	-1.8
Liver weight, right	6.4	10.6	10.7	3.2	3.3	3.3	-3.3	-3.2
Locomotor activity	0.0	0.0	0.0	0.1	0.1	0.2	-0.0	-0.0
Locomotor testing distance	1.4	2.4	2.5	-1.4	-1.5	-1.5	1.6	1.6
Locomotor testing rearing	0.0	0.0	0.0	0.2	0.1	0.0	-0.1	-0.1
Locomotion in novel chamber	1.6	2.0	2.1	-1.4	-1.4	-1.4	1.4	1.4
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.4	0.1	0.4	-0.2	-0.2
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1	0.1
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.2	0.4	0.5	-0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.4	0.4
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.3	-0.1	-0.2	0.2	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	-0.1	-0.2	0.2	0.2
Rest time, locomotor task time 1	0.2	0.2	0.6	-0.8	-0.0	-0.4	0.2	0.2
Distance moved, locomotor task time 1	0.4	0.4	1.5	1.2	0.0	0.7	-0.3	-0.4
Vertical activity count, locomotor time 1	0.1	0.1	0.3	0.0	-0.5	-0.2	0.4	0.4
Time >=10cm from walls, locomotor time 2	2.7	2.8	4.2	2.0	1.4	1.6	-1.6	-1.6
Bouts of movement, locomotor time 2	0.4	0.5	0.5	-0.7	-0.7	-0.7	0.7	0.7
Total resting periods, locomotor time 2	0.6	0.6	0.8	-0.9	-0.7	-0.8	0.8	0.7
Rest time, locomotor task time 2	1.2	1.4	3.0	-1.7	-0.8	-1.2	1.0	1.0
Distance moved, locomotor task time 2	1.9	2.2	4.9	2.2	0.9	1.5	-1.2	-1.3
Vertical activity count, locomotor time 2	0.5	0.6	1.4	1.2	0.4	0.7	-0.6	-0.6
Light reinforcement 1	0.5	0.8	0.9	0.9	0.9	0.7	-1.0	-1.0
Light reinforcement 2	0.3	0.4	0.4	0.7	0.6	0.6	-0.6	-0.6
Bone: marrow area	0.6	1.3	1.5	-1.2	-1.1	-1.2	1.1	1.1
Bone: maximum diameter	0.5	1.0	1.2	-1.1	-0.9	-1.0	1.0	1.0
Bone: maximum force	0.1	0.1	0.2	0.3	0.4	0.3	-0.4	-0.4
Bone: maximum moment	0.1	0.1	0.2	-0.4	-0.3	-0.4	0.3	0.3
Mean time between licks in bursts	6.6	9.2	9.5	3.1	3.0	3.1	-3.0	-3.0
Mean num. licks in bursts	0.0	0.0	0.1	0.3	0.0	0.1	-0.0	-0.0
Cd content in liver	1.3	1.4	1.5	-1.2	-1.1	-1.2	1.2	1.2
Co content in liver	0.1	0.1	0.1	0.3	0.4	0.3	-0.4	-0.4
Cu content in liver	0.3	0.4	0.4	0.6	0.6	0.6	-0.7	-0.7
Fe content in liver	0.7	0.8	0.9	-0.9	-0.9	-0.9	0.9	0.9
K content in liver	0.7	0.7	0.8	0.9	0.9	0.8	-0.9	-0.9
Mg content in liver	0.6	0.6	0.7	-0.7	-0.8	-0.8	0.8	0.8
Mn content in liver	0.0	0.0	0.1	0.2	0.2	0.1	-0.2	-0.2
Na content in liver	3.3	3.5	3.6	1.9	1.8	1.9	-1.8	-1.8
Rb content in liver	0.5	0.6	0.8	0.9	0.7	0.8	-0.8	-0.8
Se content in liver	1.1	1.3	1.4	-1.2	-1.1	-1.2	1.1	1.1
Sr content in liver	0.1	0.1	0.1	-0.2	-0.2	-0.2	0.2	0.2
Zn content in liver	0.9	1.0	1.0	-0.9	-1.0	-1.0	1.0	1.0
Bone: minimum diameter	1.6	3.0	3.7	-1.9	-1.6	-1.8	1.7	1.7
Time in familiar zone, hab. session 1	2.9	2.7	2.7	1.6	1.6	1.6	-1.6	-1.6
Time in novel zone, hab. session 1	7.4	7.2	7.5	-2.7	-2.7	-2.7	2.7	2.7
Total zone transitions, hab. session 1	1.6	2.2	2.5	1.3	1.6	1.5	-1.5	-1.5
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.1	0.3	0.2	-0.2	-0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.1	0.2	0.4	0.3	-0.3	-0.3
Time in familiar zone, hab. session 2	0.6	0.6	0.6	0.8	0.8	0.8	-0.8	-0.8
Time in novel zone, hab. session 2	1.2	1.2	1.2	-1.1	-1.1	-1.1	1.1	1.1
Total zone transitions, hab. session 2	4.3	5.6	5.8	2.3	2.4	2.4	-2.4	-2.4
Total locomotion distance, hab. session 2	1.6	2.1	2.2	1.4	1.5	1.5	-1.5	-1.5
Locomotion velocity, hab. session 2	1.3	1.8	1.9	1.3	1.4	1.3	-1.4	-1.4
Novel to familiar place preference ratio	1.1	1.2	1.3	-1.0	-1.1	-1.1	1.1	1.1
Novelty place preference	0.8	0.8	0.9	-0.8	-1.0	-0.9	0.9	0.9
Time in novel zone, NPP test	1.2	1.2	1.4	-1.0	-1.2	-1.1	1.1	1.1
Total zone transitions, NPP test	1.6	2.3	2.7	1.4	1.6	1.5	-1.5	-1.5
Total locomotion distance, NPP test	0.1	0.1	0.2	0.2	0.4	0.3	-0.4	-0.4
Locomotion velocity, NPP test	0.2	0.3	0.5	0.4	0.7	0.5	-0.6	-0.6
Intraocular pressure	0.0	0.0	0.0	0.2	-0.1	-0.0	0.0	0.0
Delta distance traveled before/after self-admin	1.1	1.2	2.3	-1.5	-0.6	-1.1	1.0	1.0
Delta ambulatory time before/after self-admin	0.6	0.7	1.5	-1.2	-0.4	-0.8	0.7	0.8
Parametrial fat weight	5.0	9.8	10.2	-3.0	-3.2	-3.2	3.1	3.1
Pavlov. Cond. lever latency	0.2	0.3	0.3	0.5	0.6	0.5	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.7	0.8	0.9	0.9	0.9	0.9	-0.9	-0.9
Pavlov. Cond. change in total contacts	0.3	0.3	0.3	-0.6	-0.6	-0.6	0.6	0.6
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.1	-0.1	0.0	0.0	0.0
Pavlov. Cond. magazine entry number	0.8	1.0	1.1	-1.0	-1.0	-1.0	1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	0.8	0.9	0.9	0.9	-0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1
Pavlov. Cond. response bias	0.3	0.4	0.4	0.6	0.6	0.6	-0.6	-0.6
Pavlov. Cond. lever latency	1.0	1.3	1.4	1.1	1.2	1.1	-1.2	-1.2
Pavlov. Cond. magazine entry latency	1.3	1.5	1.5	-1.2	-1.2	-1.2	1.2	1.2
Pavlov. Cond. change in total contacts	1.9	2.6	2.8	-1.6	-1.7	-1.6	1.6	1.7
Pavlov. Cond. index score	1.4	1.8	1.9	-1.3	-1.4	-1.3	1.4	1.4
Pavlov. Cond. latency score	1.1	1.4	1.4	-1.2	-1.2	-1.2	1.2	1.2
Pavlov. Cond. lever contacts	1.9	2.6	2.7	-1.5	-1.7	-1.6	1.6	1.7
Pavlov. Cond. magazine entry number	0.3	0.3	0.3	0.5	0.6	0.5	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	1.2	1.6	1.7	1.3	1.3	1.2	-1.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	1.8	-1.3	-1.3	-1.3	1.3	1.3
Pavlov. Cond. response bias	1.4	1.9	2.1	-1.3	-1.4	-1.3	1.4	1.4
Time in closed arm before self-admin	0.1	0.1	0.2	0.5	0.3	0.2	-0.3	-0.3
Time in closed arm after self-admin	0.2	0.2	0.9	1.0	-0.5	0.2	-0.0	-0.0
Time in open arm before self-admin	0.4	0.4	1.4	-1.2	-0.0	-0.4	0.5	0.5
Time in open arm after self-admin	3.3	3.7	7.7	-2.8	-1.1	-1.9	1.6	1.7
Bone: periosteal estimation	0.7	1.4	1.7	-1.3	-1.1	-1.2	1.2	1.2
Bone: periosteal perimeter	0.6	0.9	1.2	-1.1	-0.9	-1.0	0.9	0.9
Bone: post-yield work	1.7	2.4	2.6	-1.6	-1.5	-1.6	1.5	1.5
Progressive ratio test 1 active lever presses	4.4	4.6	6.6	1.7	2.6	2.0	-2.2	-2.2
Progressive ratio test 1 breakpoint	5.5	5.7	8.2	1.9	2.9	2.2	-2.5	-2.4
Progressive ratio test 1 inactive lever presses	2.0	2.1	3.5	0.8	1.9	1.3	-1.6	-1.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.7	-0.2	0.8	0.2	-0.4	-0.4
Progressive ratio test 2 breakpoint	0.2	0.3	0.8	-0.2	0.9	0.3	-0.5	-0.4
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.6	-0.5	0.8	0.1	-0.4	-0.3
Incentive Sensitization - Responses	0.3	0.3	0.4	-0.6	-0.5	-0.6	0.6	0.6
Incentive Sensitization - Breakpoint	0.5	0.5	0.7	-0.8	-0.6	-0.7	0.7	0.7
Sum of active levers in priming session hrs 5-6	1.6	1.5	2.4	0.8	1.6	1.2	-1.3	-1.2
Progressive ratio	0.2	0.2	0.2	0.4	0.5	0.5	-0.4	-0.4
Food seeking constrained by brief footshock	4.6	5.6	7.3	2.7	2.1	2.4	-2.3	-2.3
Seeking ratio, punishment vs. effort	1.0	1.3	1.9	1.4	0.9	1.1	-1.1	-1.1
Retroperitoneal fat weight	0.3	0.9	1.1	0.9	0.9	1.0	-0.9	-0.9
Reaction time number correct	0.1	0.1	0.5	-0.7	0.2	-0.2	0.2	0.2
Reaction time mean minus median	0.3	0.5	0.6	-0.6	-0.6	-0.6	0.7	0.7
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.3	0.3
Reaction time num false alarms	0.3	0.4	0.5	-0.7	-0.4	-0.7	0.5	0.6
Reaction time num false alarms AUC	0.7	0.9	1.2	-1.0	-0.8	-1.1	0.9	0.9
Reaction time trials correct on left	0.1	0.1	0.5	-0.7	0.2	-0.2	0.2	0.2
Reaction time trials on left	0.1	0.2	0.5	-0.7	0.1	-0.3	0.3	0.3
Reaction time mean	0.6	0.8	1.0	-0.7	-1.0	-0.8	1.0	1.0
Reaction time mean AUC	0.3	0.4	0.5	-0.4	-0.7	-0.5	0.7	0.7
Median of all reaction times	0.6	0.9	1.2	-0.7	-1.1	-0.9	1.0	1.0
Reaction time omissions	0.4	0.6	0.9	-0.4	-0.9	-0.8	0.8	0.8
Reaction time false alarm rate	0.7	1.0	1.2	-0.9	-1.0	-1.1	1.0	1.0
Reaction time premature initiation rate	0.4	0.5	0.8	0.6	0.9	0.6	-0.8	-0.7
Reaction time premature initiations	0.4	0.6	1.2	0.5	1.1	0.6	-0.8	-0.7
Std. dev. reaction times	1.7	2.4	2.6	-1.4	-1.6	-1.5	1.6	1.6
Reaction time trials completed	0.1	0.2	0.5	-0.7	0.1	-0.3	0.3	0.3
Reaction time trials AUC	0.1	0.2	0.6	-0.7	0.1	-0.3	0.3	0.3
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.2	0.0	0.2	-0.0	-0.0
Run reversals in cocaine runway, males	0.4	0.4	0.7	-0.8	-0.5	-0.7	0.6	0.7
Latency to leave start box in cocaine runway	0.3	0.3	0.4	0.5	0.6	0.6	-0.6	-0.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.2	0.3	0.3	-0.2	-0.2
Latency to leave start box in cocaine runway, M	0.3	0.3	0.3	0.4	0.5	0.4	-0.6	-0.6
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1
Total sessions with >9 infusions	1.5	1.7	2.5	1.2	1.6	1.1	-1.3	-1.3
Short access day 1 total inactive lever presses	0.2	0.2	0.7	-0.8	-0.1	-0.3	0.3	0.3
Short access day 10 total inactive lever presses	2.2	2.4	3.6	-1.9	-1.4	-1.5	1.5	1.5
Short access day 1 total infusions	0.0	0.0	0.1	-0.3	0.1	-0.2	0.1	0.1
Short access day 10 total infusions	0.2	0.2	0.8	-0.3	0.9	0.1	-0.4	-0.4
Short access total infusions	0.0	0.0	0.1	-0.3	0.4	-0.1	-0.1	-0.1
Short access day 1 locomotion	0.2	0.2	0.3	-0.5	-0.3	-0.5	0.4	0.4
Short access day 10 total locomotion	0.2	0.3	0.3	-0.6	-0.5	-0.5	0.5	0.5
Short access total locomotion	0.2	0.2	0.3	0.4	0.5	0.2	-0.4	-0.4
One hour access (0.3 mA shock)	0.1	0.2	0.5	-0.7	0.4	-0.3	0.0	0.1
Compulsive drug intake	4.8	4.8	6.2	-1.8	-2.5	-2.2	2.2	2.2
One hour access (shock baseline)	2.2	2.5	3.6	1.2	1.9	1.5	-1.7	-1.6
Social response proportion	0.7	0.8	1.5	-0.5	-1.2	-0.8	0.9	0.9
Social responses	0.7	0.9	1.1	1.1	0.8	1.0	-0.9	-0.9
Social time	0.1	0.2	0.6	0.8	-0.1	0.3	-0.1	-0.2
Soleus weight	0.1	0.2	0.2	0.4	0.5	0.5	-0.5	-0.5
Bone: stiffness	0.1	0.1	0.2	0.2	0.4	0.3	-0.4	-0.4
Tibialis anterior weight	7.9	27.0	27.1	-5.2	-5.2	-5.2	5.2	5.2
Time to tail flick, vehicle, before self-admin	1.9	2.0	2.5	-1.6	-1.1	-1.5	1.4	1.4
Time to tail flick, vehicle, after self-admin	1.8	1.9	2.1	-1.3	-1.5	-1.4	1.4	1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.3	-0.4	-0.6	-0.6	0.4	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.2	-0.3	-0.4	0.2	0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.8	0.9	0.0	0.5	-0.4	-0.4
Delta time to tail flick, test, before/after SA	0.2	0.1	0.2	-0.3	-0.4	-0.4	0.4	0.4
Tibia length	2.3	6.5	7.0	2.5	2.6	2.4	-2.6	-2.6
Ambulatory time before self-admin	0.1	0.1	0.2	0.1	0.4	0.4	-0.3	-0.3
Ambulatory time after self-admin	0.5	0.5	1.3	-1.1	-0.3	-0.6	0.7	0.7
Bone: tissue strength	0.5	0.5	0.6	-0.7	-0.7	-0.8	0.7	0.7
Total heroin consumption	0.7	0.8	1.6	1.2	0.7	0.9	-0.8	-0.8
Bone: trabecular number	0.0	0.0	0.1	0.1	0.3	0.2	-0.2	-0.2
Bone: trabecular spacing	0.0	0.0	0.0	0.2	0.1	0.1	-0.1	-0.1
Bone: trabecular thickness	0.0	0.0	0.1	0.2	0.3	0.2	-0.2	-0.2
Bone: trabecular tissue density	16.2	22.8	23.1	4.7	4.8	4.8	-4.8	-4.8
Water consumed over 24 hours	0.2	0.2	0.2	-0.5	-0.4	-0.5	0.4	0.4
Number of responses in last shaping day	0.2	0.2	0.6	0.0	0.8	0.3	-0.5	-0.4