Hub : Genes

Kank4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Kank4	0.12	0.13	1.7e-09	0.09	0.08	0.08	0.09	3.0e-10	6.1e-09	1.8e-09	9.1e-10
2	Adipose	gene expression	Kank4	0.22	0.17	4.3e-12	0.08	0.07	0.08	0.08	9.0e-09	2.1e-08	2.4e-09	4.5e-09
3	BLA	gene expression	Kank4	0.17	0.13	1.7e-08	0.08	0.15	0.12	0.12	4.6e-05	3.0e-08	5.1e-07	4.7e-07
4	pVTA	gene expression	Kank4	0.06	0.06	6.8e-05	0.05	0.05	0.04	0.05	9.2e-05	9.9e-05	3.8e-04	7.1e-05
5	NAcc	gene expression	Kank4	0.04	0.04	6.7e-08	0.04	0.04	0.04	0.04	5.4e-07	1.9e-07	2.6e-07	6.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.4	0.7	0.8	0.8	0.9	-0.9	-0.9	-0.9
Area under the delay curve	0.5	0.8	1.3	1.1	0.7	-0.9	-0.9	-0.9
BMI with tail	0.6	1.9	2.2	-1.5	-1.4	1.4	1.3	1.4
BMI without tail	0.7	3.6	3.7	-1.8	-1.9	1.9	1.9	1.9
Body weight	0.2	0.7	1.5	-0.4	-1.2	0.8	0.8	0.8
Weight adjusted by age	0.5	1.4	1.8	-1.4	-1.0	1.2	1.1	1.2
Bone surface	1.7	3.4	3.7	-1.9	-1.8	1.8	1.8	1.8
Bone volume	0.4	0.7	0.8	-0.9	-0.8	0.8	0.8	0.8
Breakpoint value in progressive ratio session	0.2	0.4	0.7	0.8	0.5	-0.6	-0.3	-0.6
Number of licking bursts	0.0	0.1	0.2	-0.2	-0.5	0.3	0.4	0.3
Context. condit. distance diff. score	2.7	3.2	3.6	1.7	1.9	-1.8	-1.8	-1.8
Locomotion velocity, session 1	0.1	0.1	0.1	-0.2	-0.3	0.3	0.3	0.3
Locomotion distance, session 1	0.7	0.9	1.0	1.0	0.9	-0.9	-0.9	-0.9
Locomotion velocity, session 2	0.2	0.3	0.4	-0.4	-0.6	0.5	0.6	0.5
Locomotion distance, session 2	0.1	0.2	0.4	-0.2	-0.7	0.4	0.4	0.4
Locomotion velocity, session 3	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.0	-0.1
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.0
Stereotopy head waving bouts, day 3	0.4	0.5	0.5	0.7	0.7	-0.7	-0.7	-0.7
Stereotopy head waving duration, day 3	0.7	0.9	1.0	1.0	0.9	-0.9	-0.9	-1.0
Locomotion velocity, session 7	0.3	0.3	0.3	0.6	0.5	-0.6	-0.5	-0.6
Locomotion distance, session 7	0.2	0.3	0.3	0.6	0.5	-0.5	-0.5	-0.5
Stereotopy head waving bouts, day 7	1.0	1.2	1.3	-1.0	-1.1	1.1	1.1	1.1
Stereotopy head waving duration, day 7	1.1	1.3	1.4	-1.0	-1.2	1.1	1.2	1.1
Locomotion velocity, session 8	0.4	0.5	0.6	0.6	0.8	-0.7	-0.7	-0.7
Locomotion distance, session 8	0.9	1.3	1.3	1.1	1.1	-1.1	-1.1	-1.1
Degree of sensitization distance	0.1	0.1	0.2	-0.4	-0.3	0.3	0.3	0.3
Degree of sensitization stereotypy	1.2	1.4	1.4	-1.1	-1.2	1.2	1.2	1.2
Conditioned locomotion	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2
Cocaine response after cond. corrected	0.6	0.9	1.2	-0.9	-1.0	0.9	1.1	0.9
Cocaine response after cond. not corrected	0.5	0.7	0.8	-0.8	-0.9	0.8	0.9	0.8
Cocaine response before conditioning	0.0	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1
Saline control response	0.0	0.0	0.1	0.2	0.1	-0.2	-0.2	-0.1
Bone: connectivity density	1.2	2.0	2.1	-1.5	-1.4	1.4	1.3	1.4
Bone: cortical apparent density	4.9	7.7	7.9	2.7	2.8	-2.8	-2.7	-2.8
Bone: cortical area	0.2	0.4	0.5	-0.6	-0.7	0.6	0.6	0.6
Bone: cortical porosity	0.3	0.4	0.5	-0.5	-0.7	0.6	0.6	0.6
Bone: cortical porosity	0.6	0.6	0.8	-0.6	-0.9	0.8	0.8	0.8
Bone: cortical thickness	0.2	0.3	0.3	0.6	0.5	-0.6	-0.5	-0.6
Bone: cortical thickness	0.0	0.0	0.0	0.2	0.2	-0.2	-0.2	-0.2
Bone: cortical tissue density	4.8	7.6	7.9	2.7	2.8	-2.8	-2.7	-2.8
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.3
Condit. Reinf. active responses	0.3	0.4	0.5	-0.5	-0.7	0.6	0.6	0.6
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.5	-0.7	0.6	0.6	0.6
Incentive salience index mean	0.0	0.0	0.0	-0.2	-0.2	0.2	0.2	0.2
Condit. Reinf. lever presses	0.1	0.1	0.1	0.3	0.2	-0.3	-0.3	-0.3
Condit. Reinf. active minus inactive responses	1.0	1.5	1.6	1.2	1.2	-1.2	-1.2	-1.2
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.5	0.6	0.7	-0.7	-0.7	-0.7
Condit. Reinf. active responses	0.9	1.3	1.5	1.1	1.2	-1.1	-1.2	-1.1
Condit. Reinf. inactive responses	1.5	2.2	2.4	1.5	1.5	-1.5	-1.6	-1.4
Condit. Reinf. lever presses	1.8	2.6	2.6	-1.6	-1.6	1.6	1.6	1.6
Condit. Reinf. lever reinforcers received	0.4	0.5	0.6	0.7	0.8	-0.7	-0.8	-0.7
Conditioned reinforcement - actives	0.0	0.1	0.2	0.4	0.5	-0.2	-0.4	-0.3
Conditioned reinforcement - inactives	0.2	0.6	1.3	1.1	0.2	-0.7	-0.9	-0.7
Conditioned locomotion	0.3	0.4	0.8	0.9	0.5	-0.5	-0.8	-0.5
Patch foraging indifference point 0 sec	3.7	10.4	10.9	-3.2	-3.3	3.2	3.2	3.2
Patch foraging indifference point AUC	0.6	1.5	1.8	-1.1	-1.3	1.1	1.3	1.1
Delay disc. indifference point, 0s delay	2.3	2.5	3.0	1.7	1.5	-1.5	-1.6	-1.6
Delay disc. indifference point, 16s delay	0.4	0.6	0.7	-0.7	-0.9	0.8	0.8	0.8
Delay disc. indifference point, 2s delay	0.2	0.3	0.3	0.5	0.6	-0.5	-0.4	-0.5
Delay disc. indifference point, 24s delay	0.1	0.2	0.2	0.4	0.4	-0.5	-0.4	-0.4
Delay disc. indifference point, 4s delay	3.2	3.4	4.8	2.2	1.5	-1.9	-1.8	-1.8
Delay disc. indifference point, 8s delay	1.2	2.1	2.7	1.7	1.2	-1.4	-1.5	-1.4
Indifference point function ln k	0.1	0.2	0.3	0.3	0.6	-0.4	-0.5	-0.4
Indifference point function log k	0.1	0.2	0.3	0.3	0.6	-0.4	-0.5	-0.4
Patch foraging total patch changes 0 sec	3.3	9.7	10.3	-3.1	-3.2	3.1	3.0	3.1
Patch foraging total patch changes 12 sec	0.7	1.0	1.1	-1.1	-0.9	0.9	1.0	1.0
Patch foraging total patch changes 18 sec	1.1	2.5	3.1	-1.4	-1.8	1.6	1.6	1.6
Patch foraging total patch changes 24 sec	0.6	2.1	2.4	-1.3	-1.6	1.4	1.5	1.4
Patch foraging total patch changes 6 sec	2.1	3.5	4.0	-1.8	-2.0	1.8	1.8	1.9
Patch foraging time to switch 0 sec	0.6	2.4	2.9	1.4	1.5	-1.5	-1.7	-1.5
Patch foraging water rate 0 sec	0.7	2.5	2.9	-1.4	-1.7	1.6	1.7	1.6
Patch foraging water rate 12 sec	1.3	5.2	6.1	-2.0	-2.5	2.3	2.3	2.3
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.3	-0.5	0.5	0.5	0.5
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.2	-0.3	0.1	0.1	0.1
Patch foraging water rate 6 sec	0.1	0.2	0.3	-0.3	-0.5	0.5	0.5	0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.4	-0.3	-0.2	0.2	-0.1
Distance traveled before self-admin	0.1	0.3	0.4	-0.3	-0.5	0.5	0.7	0.5
Distance traveled after self-admin	0.4	0.7	1.4	-0.2	-1.2	0.7	0.9	0.8
Extensor digitorum longus weight	0.6	2.4	2.5	1.5	1.6	-1.5	-1.6	-1.5
Bone: elastic displacement	0.7	0.9	1.1	0.9	1.0	-0.9	-0.9	-0.9
Bone: elastic work	1.8	2.3	2.4	1.5	1.5	-1.5	-1.5	-1.5
Bone: endosteal estimation	0.8	1.9	2.1	-1.4	-1.4	1.4	1.4	1.4
Bone: endosteal perimeter	1.3	3.3	3.4	-1.8	-1.8	1.8	1.8	1.8
Epididymis fat weight	0.0	0.2	0.4	0.6	0.1	-0.4	-0.3	-0.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.6	-0.3	0.7	0.1	-0.0	0.0
Delta time in open arm before/after self-admin	1.7	2.0	3.7	-1.2	-1.9	1.3	1.2	1.4
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	-0.2	-0.5	0.4	0.6	0.4
Delay discount exponential model param	0.6	0.8	1.3	-1.1	-0.7	0.9	0.9	0.9
Extinction: sum of active levers before priming	0.3	0.4	0.5	0.7	0.6	-0.6	-0.7	-0.5
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.0	-0.2	0.2	0.0	0.2
Bone: final force	0.2	0.3	0.3	0.5	0.6	-0.6	-0.5	-0.6
Bone: final moment	0.0	0.0	0.0	-0.1	-0.0	0.0	0.1	0.0
Food consumed during 24 hour testing period	0.2	0.3	0.5	0.7	0.5	-0.6	-0.6	-0.5
Glucose	0.1	0.1	0.2	-0.3	-0.4	0.4	0.4	0.4
Heart weight	2.4	3.8	4.0	2.0	2.0	-2.0	-1.8	-2.0
Delay discount hyperbolic model param	0.6	0.7	1.1	-1.0	-0.7	0.9	0.8	0.8
Intermittent access intake day 1-15 change	0.0	0.1	0.2	0.4	0.0	-0.2	-0.2	-0.2
Intermittent access intake escalation	0.0	0.2	0.3	0.6	0.3	-0.4	-0.3	-0.5
Intermittent access intake escalation 2	0.1	0.2	0.5	0.7	0.1	-0.4	-0.2	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.5	-0.3	-0.7	0.3	0.2	0.3
Intermitt. access day 15 inactive lever presses	0.3	1.8	2.2	1.5	0.9	-1.3	-1.5	-1.3
Intermitt. access escalation Index	0.1	0.4	1.0	-1.0	0.3	0.5	0.6	0.4
Intermittent access day 1 total infusions	0.5	1.4	2.1	1.5	0.8	-1.2	-1.3	-1.2
Intermittent access day 15 total infusions	0.4	1.0	1.3	1.1	0.9	-1.0	-1.0	-1.0
Intermittent access terminal intake (last 3 days)	0.3	0.5	1.3	1.1	0.1	-0.7	-0.6	-0.6
Intermittent access total infusions	1.3	1.5	2.2	1.5	0.9	-1.2	-1.2	-1.2
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.5	-0.1	-0.2	-0.4	-0.2
Intermittent access day 15 total locomotion	0.0	0.1	0.2	0.5	-0.4	-0.0	-0.2	0.0
Intermittent access total locomotion	0.0	0.1	0.2	0.3	-0.4	-0.0	-0.0	-0.0
Intermittent access standard deviation	0.1	0.8	1.0	0.9	0.6	-0.9	-1.0	-0.9
Left kidney weight	0.1	0.5	0.8	0.9	0.4	-0.7	-0.6	-0.7
Right kidney weight	0.1	0.5	0.8	0.9	0.3	-0.8	-0.5	-0.7
Cocaine induced anxiety	0.0	0.0	0.0	-0.2	-0.0	-0.0	0.0	-0.0
Post-drug Anxiety	0.1	0.1	0.2	-0.1	0.5	-0.2	-0.2	-0.2
Baseline Anxiety	0.0	0.0	0.2	-0.1	0.4	-0.0	-0.1	-0.1
Tail length	0.1	0.4	1.3	1.1	0.0	-0.5	-0.3	-0.5
Length with tail	0.1	0.4	1.4	1.2	-0.1	-0.5	-0.3	-0.4
Length without tail	0.0	0.1	0.4	0.6	-0.2	-0.2	-0.2	-0.1
Times rat made contact with spout	0.0	0.0	0.0	-0.1	0.0	0.1	0.0	0.1
Lifetime Intake	1.3	1.6	2.3	1.5	1.0	-1.3	-1.3	-1.2
Liver weight, left	2.9	5.0	6.0	2.4	2.0	-2.2	-2.2	-2.2
Liver weight, right	2.0	3.5	3.9	2.0	1.7	-1.9	-1.9	-1.9
Locomotor activity	0.0	0.0	0.0	0.1	0.1	0.0	0.1	0.0
Locomotor testing distance	0.9	2.1	2.2	-1.4	-1.4	1.5	1.5	1.5
Locomotor testing rearing	0.0	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.1
Locomotion in novel chamber	2.0	2.7	3.1	-1.8	-1.5	1.7	1.6	1.6
Locomotion in novel chamber post-restriction	0.1	0.4	1.0	0.3	1.0	-0.6	-0.6	-0.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	0.0	-0.2	0.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.4	-0.4	-0.2	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.1	-0.5	0.4	0.2	0.4
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.1	-0.3	0.2	0.1	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.0	-0.4	0.2	0.2	0.2
Rest time, locomotor task time 1	0.3	0.5	1.1	-0.4	-1.0	0.6	0.6	0.6
Distance moved, locomotor task time 1	0.1	0.4	1.4	0.0	1.2	-0.3	-0.4	-0.4
Vertical activity count, locomotor time 1	0.0	0.2	0.3	-0.6	-0.1	0.5	0.4	0.4
Time >=10cm from walls, locomotor time 2	1.1	3.2	3.7	1.7	1.9	-1.7	-1.9	-1.7
Bouts of movement, locomotor time 2	0.2	0.6	0.7	-0.7	-0.8	0.8	0.6	0.8
Total resting periods, locomotor time 2	0.2	0.7	0.9	-0.8	-0.9	0.8	0.7	0.8
Rest time, locomotor task time 2	0.7	1.1	2.0	-0.9	-1.4	0.9	1.1	0.9
Distance moved, locomotor task time 2	1.4	1.9	4.1	0.8	2.0	-1.2	-1.3	-1.2
Vertical activity count, locomotor time 2	0.2	0.4	0.9	0.4	1.0	-0.5	-0.7	-0.5
Light reinforcement 1	0.1	0.7	0.7	0.8	0.8	-0.8	-0.8	-0.8
Light reinforcement 2	0.1	0.2	0.4	0.2	0.6	-0.5	-0.3	-0.5
Bone: marrow area	0.7	1.7	1.8	-1.3	-1.3	1.3	1.3	1.3
Bone: maximum diameter	0.4	0.9	1.0	-0.9	-1.0	0.9	0.9	0.9
Bone: maximum force	0.0	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.1
Bone: maximum moment	0.2	0.3	0.4	-0.6	-0.6	0.6	0.6	0.6
Mean time between licks in bursts	1.4	8.2	8.5	2.8	2.9	-2.9	-2.9	-2.8
Mean num. licks in bursts	0.0	0.0	0.1	0.1	0.3	-0.1	-0.2	-0.1
Cd content in liver	0.9	1.0	1.0	-1.0	-1.0	1.0	1.0	1.0
Co content in liver	0.0	0.0	0.0	0.2	0.2	-0.2	-0.2	-0.2
Cu content in liver	0.9	1.1	1.1	1.0	1.0	-1.0	-1.0	-1.0
Fe content in liver	0.0	0.1	0.1	0.2	0.3	-0.2	-0.2	-0.2
K content in liver	1.7	1.6	1.8	1.3	1.2	-1.3	-1.3	-1.3
Mg content in liver	0.5	0.6	0.7	-0.7	-0.8	0.8	0.8	0.7
Mn content in liver	0.1	0.1	0.3	-0.2	-0.5	0.3	0.3	0.3
Na content in liver	3.4	3.8	4.6	1.8	2.1	-1.9	-1.9	-1.9
Rb content in liver	0.3	0.4	0.4	0.6	0.5	-0.6	-0.6	-0.7
Se content in liver	0.1	0.1	0.2	-0.3	-0.4	0.4	0.4	0.4
Sr content in liver	1.2	1.0	1.4	-1.2	-0.8	1.0	1.0	1.0
Zn content in liver	0.8	1.0	1.0	-1.0	-0.9	1.0	1.0	1.0
Bone: minimum diameter	1.7	3.2	3.8	-1.7	-2.0	1.8	1.8	1.8
Time in familiar zone, hab. session 1	2.6	2.8	3.2	1.8	1.6	-1.7	-1.7	-1.7
Time in novel zone, hab. session 1	6.6	7.4	8.2	-2.9	-2.6	2.7	2.7	2.7
Total zone transitions, hab. session 1	1.5	2.2	2.3	1.4	1.5	-1.5	-1.5	-1.5
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.3	0.2	-0.3	-0.3	-0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.1	0.4	0.3	-0.3	-0.3	-0.3
Time in familiar zone, hab. session 2	0.5	0.6	0.7	0.8	0.7	-0.8	-0.7	-0.8
Time in novel zone, hab. session 2	1.0	1.1	1.3	-1.1	-1.0	1.1	1.1	1.0
Total zone transitions, hab. session 2	4.3	5.5	5.6	2.3	2.3	-2.4	-2.3	-2.4
Total locomotion distance, hab. session 2	1.8	2.3	2.5	1.6	1.4	-1.5	-1.5	-1.6
Locomotion velocity, hab. session 2	1.5	2.0	2.2	1.5	1.3	-1.4	-1.4	-1.4
Novel to familiar place preference ratio	0.9	1.1	1.5	-1.2	-0.9	1.1	1.0	1.0
Novelty place preference	0.6	0.8	1.1	-1.0	-0.7	0.9	0.9	0.9
Time in novel zone, NPP test	1.0	1.2	1.6	-1.3	-1.0	1.1	1.1	1.1
Total zone transitions, NPP test	1.6	2.3	2.6	1.6	1.4	-1.5	-1.5	-1.5
Total locomotion distance, NPP test	0.1	0.1	0.2	0.4	0.2	-0.4	-0.3	-0.4
Locomotion velocity, NPP test	0.2	0.3	0.5	0.7	0.5	-0.6	-0.6	-0.6
Intraocular pressure	0.0	0.1	0.1	0.1	0.4	-0.2	-0.2	-0.2
Delta distance traveled before/after self-admin	0.4	0.4	1.0	-0.3	-1.0	0.5	0.7	0.5
Delta ambulatory time before/after self-admin	0.1	0.2	0.7	0.0	-0.8	0.3	0.4	0.3
Parametrial fat weight	6.9	16.1	16.5	-4.0	-4.0	4.1	4.0	4.0
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.8	0.3	-0.5	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.6	0.8	-0.7	-0.8	-0.7
Pavlov. Cond. change in total contacts	0.4	0.4	0.7	-0.8	-0.6	0.7	0.6	0.7
Pavlov. Cond. index score	0.0	0.0	0.1	-0.2	0.2	-0.0	-0.1	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	0.2	0.0	0.0	0.0
Pavlov. Cond. lever contacts	0.0	0.0	0.2	-0.4	0.1	0.1	0.1	0.2
Pavlov. Cond. magazine entry number	0.9	1.1	1.3	-0.9	-1.1	1.0	1.1	1.0
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.9	1.0	0.8	-0.9	-0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.3	0.1	0.1	0.0	0.1
Pavlov. Cond. response bias	0.2	0.2	0.3	0.2	0.6	-0.4	-0.5	-0.4
Pavlov. Cond. lever latency	1.5	2.0	2.2	1.5	1.4	-1.4	-1.4	-1.5
Pavlov. Cond. magazine entry latency	1.1	1.6	1.7	-1.3	-1.2	1.3	1.2	1.3
Pavlov. Cond. change in total contacts	1.0	2.4	2.6	-1.6	-1.5	1.6	1.5	1.6
Pavlov. Cond. index score	1.1	1.7	1.9	-1.4	-1.2	1.3	1.2	1.3
Pavlov. Cond. latency score	0.9	1.4	1.6	-1.3	-1.1	1.2	1.1	1.2
Pavlov. Cond. lever contacts	1.5	2.3	2.4	-1.6	-1.4	1.5	1.5	1.5
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	0.7	0.5	-0.6	-0.5	-0.7
Pavlov. Cond. intertrial magazine entries	0.7	1.6	1.7	1.3	1.3	-1.3	-1.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.8	2.0	-1.4	-1.3	1.4	1.3	1.4
Pavlov. Cond. response bias	1.2	1.7	1.9	-1.4	-1.2	1.3	1.3	1.4
Time in closed arm before self-admin	0.1	0.1	0.2	0.2	0.4	-0.5	-0.2	-0.5
Time in closed arm after self-admin	0.3	0.4	1.5	-0.1	1.2	-0.4	-0.1	-0.5
Time in open arm before self-admin	0.4	0.5	1.4	0.2	-1.2	0.6	0.6	0.6
Time in open arm after self-admin	3.6	3.9	7.9	-1.3	-2.8	1.9	1.7	1.9
Bone: periosteal estimation	0.7	1.7	1.9	-1.3	-1.4	1.3	1.3	1.3
Bone: periosteal perimeter	0.5	0.9	1.1	-0.9	-1.1	1.0	1.0	1.0
Bone: post-yield work	1.4	2.3	2.5	-1.5	-1.6	1.5	1.5	1.5
Progressive ratio test 1 active lever presses	2.3	4.0	4.6	2.2	1.8	-2.0	-2.0	-2.0
Progressive ratio test 1 breakpoint	2.7	4.6	5.4	2.3	1.9	-2.2	-2.2	-2.1
Progressive ratio test 1 inactive lever presses	1.8	4.7	5.5	2.4	1.7	-2.2	-2.3	-2.2
Progressive ratio test 2 active lever presses	0.1	0.2	0.6	0.7	0.1	-0.4	-0.3	-0.4
Progressive ratio test 2 breakpoint	0.2	0.3	0.8	0.9	0.2	-0.5	-0.4	-0.5
Progressive ratio test 2 inactive lever presses	0.2	0.5	1.3	1.2	-0.0	-0.7	-0.6	-0.6
Incentive Sensitization - Responses	0.1	0.3	0.3	-0.5	-0.4	0.5	0.5	0.5
Incentive Sensitization - Breakpoint	0.2	0.5	0.6	-0.6	-0.7	0.7	0.8	0.7
Sum of active levers in priming session hrs 5-6	0.3	0.2	0.5	0.7	0.2	-0.5	-0.4	-0.5
Progressive ratio	0.1	0.2	0.4	0.7	0.2	-0.4	-0.4	-0.4
Food seeking constrained by brief footshock	4.6	5.8	7.1	2.2	2.7	-2.4	-2.4	-2.4
Seeking ratio, punishment vs. effort	0.6	1.4	1.9	0.9	1.4	-1.2	-1.2	-1.2
Retroperitoneal fat weight	0.5	2.3	3.1	-1.2	-1.8	1.5	1.6	1.4
Reaction time number correct	0.0	0.1	0.5	0.3	-0.7	0.2	0.3	0.2
Reaction time mean minus median	0.1	0.5	0.6	-0.7	-0.6	0.8	0.7	0.8
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.3	-0.1	0.3	0.2	0.3
Reaction time num false alarms	0.2	0.3	0.5	-0.4	-0.7	0.5	0.4	0.5
Reaction time num false alarms AUC	0.4	0.9	1.2	-0.8	-1.1	0.9	0.8	0.9
Reaction time trials correct on left	0.0	0.1	0.5	0.3	-0.7	0.2	0.3	0.2
Reaction time trials on left	0.0	0.2	0.5	0.2	-0.7	0.3	0.3	0.3
Reaction time mean	0.5	1.0	1.2	-1.1	-0.7	1.1	1.0	1.1
Reaction time mean AUC	0.2	0.5	0.6	-0.8	-0.4	0.8	0.7	0.8
Median of all reaction times	0.7	1.1	1.4	-1.2	-0.8	1.1	1.1	1.1
Reaction time omissions	0.6	1.0	1.7	-1.3	-0.6	1.0	1.1	1.0
Reaction time false alarm rate	0.7	0.9	1.2	-1.1	-0.9	0.9	0.8	1.0
Reaction time premature initiation rate	0.3	0.4	0.5	0.6	0.6	-0.7	-0.6	-0.6
Reaction time premature initiations	0.2	0.6	1.0	1.0	0.5	-0.8	-0.7	-0.7
Std. dev. reaction times	0.8	2.6	2.8	-1.7	-1.4	1.7	1.6	1.7
Reaction time trials completed	0.0	0.2	0.5	0.2	-0.7	0.3	0.3	0.3
Reaction time trials AUC	0.0	0.2	0.5	0.2	-0.7	0.3	0.3	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.4	0.1	0.6	-0.3	-0.3	-0.3
Run reversals in cocaine runway, males	0.6	0.7	0.9	-0.7	-0.9	0.8	0.9	0.8
Latency to leave start box in cocaine runway	0.2	0.3	0.4	0.7	0.5	-0.6	-0.5	-0.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4	0.3
Latency to leave start box in cocaine runway, M	1.0	0.9	1.1	1.0	0.9	-1.0	-0.9	-1.0
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	0.1
Total sessions with >9 infusions	2.2	2.7	3.6	1.9	1.3	-1.6	-1.8	-1.6
Short access day 1 total inactive lever presses	0.1	0.1	0.1	0.4	0.2	-0.3	-0.4	-0.3
Short access day 10 total inactive lever presses	0.3	1.8	2.5	-1.2	-1.6	1.4	1.1	1.4
Short access day 1 total infusions	0.2	0.4	0.5	0.7	0.6	-0.5	-0.7	-0.5
Short access day 10 total infusions	1.1	1.8	2.4	1.6	1.0	-1.3	-1.5	-1.3
Short access total infusions	0.9	1.2	1.5	1.2	1.0	-1.0	-1.2	-1.0
Short access day 1 locomotion	0.1	0.1	0.2	0.3	0.3	-0.3	-0.4	-0.3
Short access day 10 total locomotion	0.1	0.3	0.5	-0.5	-0.7	0.6	0.5	0.6
Short access total locomotion	0.3	0.5	0.7	0.8	0.5	-0.6	-0.8	-0.6
One hour access (0.3 mA shock)	0.1	0.1	0.4	0.6	-0.3	-0.2	-0.3	-0.1
Compulsive drug intake	2.3	3.3	4.4	-2.1	-1.5	1.9	1.7	1.9
One hour access (shock baseline)	0.9	2.4	3.5	1.9	1.1	-1.6	-1.5	-1.6
Social response proportion	0.8	1.0	1.5	-1.2	-0.7	1.0	1.0	1.0
Social responses	0.6	0.8	0.9	0.8	0.9	-0.9	-0.8	-0.9
Social time	0.1	0.1	0.5	-0.2	0.7	-0.1	-0.1	-0.1
Soleus weight	0.0	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.3
Bone: stiffness	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.0
Tibialis anterior weight	8.1	27.8	28.6	-5.4	-5.3	5.3	5.2	5.3
Time to tail flick, vehicle, before self-admin	1.3	1.6	2.0	-0.9	-1.4	1.3	1.3	1.3
Time to tail flick, vehicle, after self-admin	1.0	2.0	2.5	-1.4	-1.5	1.3	1.6	1.3
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.1	-0.2	0.0	-0.2	0.0
Time to tail flick, test, after self-admin	0.2	0.2	0.2	0.5	0.4	-0.4	-0.5	-0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.1	0.5	-0.3	-0.2	-0.3
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.5	-0.2	0.3	0.4	0.3
Tibia length	2.6	7.3	7.9	2.8	2.5	-2.7	-2.7	-2.7
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	-0.1	0.1	0.2	0.1
Ambulatory time after self-admin	0.2	0.3	0.5	-0.0	-0.7	0.5	0.6	0.5
Bone: tissue strength	0.2	0.2	0.2	-0.4	-0.4	0.4	0.4	0.4
Total heroin consumption	0.3	0.3	0.5	0.5	0.7	-0.5	-0.4	-0.5
Bone: trabecular number	0.1	0.2	0.2	0.4	0.4	-0.5	-0.5	-0.5
Bone: trabecular spacing	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0	-0.0
Bone: trabecular thickness	0.1	0.2	0.2	0.4	0.4	-0.4	-0.4	-0.4
Bone: trabecular tissue density	11.8	20.6	20.8	4.5	4.5	-4.6	-4.6	-4.6
Water consumed over 24 hours	0.0	0.0	0.0	-0.0	-0.1	0.0	0.1	0.1
Number of responses in last shaping day	0.2	0.2	0.4	0.5	0.3	-0.4	-0.6	-0.4