Rin1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Rin1	0.16	0.09	3.7e-07	0.12	0.14	0.13	0.14	8.2e-07	4.6e-08	2.9e-07	1.0e-07
2	PL	gene expression	Rin1	0.1	0.06	1.9e-08	0.05	0.06	0.05	0.05	1.3e-06	1.3e-07	2.0e-06	3.5e-06
3	IC	gene expression	Rin1	0.32	0.18	8.1e-07	0.09	0.14	0.14	0.14	9.5e-05	2.9e-06	1.3e-06	2.3e-06
4	Brain	gene expression	Rin1	0.27	0.11	0.0e+00	0.21	0.21	0.22	0.22	1.1e-19	9.6e-20	6.1e-20	2.1e-20
5	NAcc	gene expression	Rin1	0.08	0.04	5.0e-10	0.07	0.07	0.07	0.07	2.2e-11	9.5e-11	4.1e-11	9.1e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.6	4.8	6.0	-1.8	-2.4	2.4	-2.2	2.0
Area under the delay curve	0.4	0.5	1.0	-0.1	-0.7	1.0	-0.6	1.0
BMI with tail	5.3	18.5	20.8	-3.8	-4.5	4.5	-4.6	4.1
BMI without tail	1.4	7.4	10.9	-2.3	-2.8	3.3	-2.6	2.4
Body weight	2.6	11.2	15.1	-3.9	-3.6	3.7	-2.9	2.3
Weight adjusted by age	0.2	0.7	1.9	-1.4	-0.8	0.8	-0.5	0.1
Bone surface	5.9	11.5	14.1	-3.7	-3.8	3.1	-3.4	2.8
Bone volume	3.0	6.1	7.9	-2.5	-2.8	2.3	-2.5	2.1
Breakpoint value in progressive ratio session	1.4	2.6	5.2	-2.3	-1.8	1.4	-1.6	0.5
Number of licking bursts	0.1	0.4	0.7	-0.8	-0.7	0.5	-0.7	0.5
Context. condit. distance diff. score	1.0	1.2	2.4	1.5	1.2	-0.9	0.9	-0.7
Locomotion velocity, session 1	0.2	0.2	0.4	0.5	0.5	-0.3	0.7	-0.3
Locomotion distance, session 1	1.8	2.3	3.3	-1.1	-1.6	1.8	-1.3	1.6
Locomotion velocity, session 2	2.0	2.4	3.3	-1.8	-1.6	1.8	-1.3	1.1
Locomotion distance, session 2	1.3	1.9	3.2	-1.2	-1.5	1.8	-0.8	1.3
Locomotion velocity, session 3	0.2	0.2	0.7	-0.0	-0.4	0.5	-0.2	0.8
Locomotion distance, session 3	0.0	0.0	0.1	0.1	0.0	0.1	0.2	0.4
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	0.7	0.1	0.4	0.2	0.6
Stereotopy head waving duration, day 3	0.1	0.2	0.7	0.8	0.2	0.1	0.1	0.4
Locomotion velocity, session 7	0.4	0.5	0.8	-0.1	-0.5	0.7	-0.9	0.9
Locomotion distance, session 7	0.2	0.2	0.8	-0.1	-0.4	0.9	-0.4	0.4
Stereotopy head waving bouts, day 7	0.5	0.6	1.6	-0.5	-0.7	0.3	-0.9	1.2
Stereotopy head waving duration, day 7	2.0	2.4	3.2	-1.5	-1.6	1.2	-1.6	1.8
Locomotion velocity, session 8	0.2	0.2	0.5	-0.7	-0.5	0.7	0.0	0.1
Locomotion distance, session 8	0.0	0.0	0.2	0.4	0.1	0.1	0.1	0.1
Degree of sensitization distance	0.4	0.5	0.8	-0.3	-0.6	0.9	-0.8	0.6
Degree of sensitization stereotypy	1.0	1.1	1.5	-1.2	-1.1	0.5	-1.2	1.1
Conditioned locomotion	0.3	0.4	1.0	-1.0	-0.5	0.7	-0.3	-0.2
Cocaine response after cond. corrected	0.7	1.0	1.7	1.3	1.1	-0.9	0.8	-0.8
Cocaine response after cond. not corrected	0.3	0.5	1.0	1.0	0.8	-0.7	0.5	-0.4
Cocaine response before conditioning	0.7	0.9	1.4	-1.2	-1.1	0.6	-0.9	0.8
Saline control response	2.5	3.5	5.3	-2.3	-2.0	2.1	-1.5	1.2
Bone: connectivity density	5.4	8.6	10.1	-2.8	-3.2	3.1	-3.0	2.5
Bone: cortical apparent density	0.1	0.1	0.2	-0.0	0.4	-0.3	0.3	-0.4
Bone: cortical area	0.2	0.3	1.0	-1.0	-0.5	0.1	-0.2	-0.5
Bone: cortical porosity	0.5	0.6	1.1	-0.6	-0.9	1.1	-0.5	0.6
Bone: cortical porosity	0.7	0.8	1.6	-0.8	-1.0	1.3	-0.6	0.4
Bone: cortical thickness	0.4	0.7	2.5	-1.6	-0.4	0.3	0.4	-0.9
Bone: cortical thickness	0.1	0.2	0.5	-0.2	0.3	0.2	0.7	-0.3
Bone: cortical tissue density	0.0	0.1	0.2	-0.1	0.3	-0.2	0.3	-0.4
Condit. Reinf. active minus inactive responses	0.6	0.7	0.8	-0.8	-0.9	0.8	-0.9	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.5	-0.5	0.3	-0.7	0.6
Condit. Reinf. active responses	0.3	0.4	0.4	-0.6	-0.6	0.6	-0.6	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	-0.2	0.2	0.0	0.1
Incentive salience index mean	0.8	1.1	1.2	-1.0	-1.1	1.1	-1.1	0.8
Condit. Reinf. lever presses	0.3	0.5	1.0	-1.0	-0.8	0.5	-0.8	0.1
Condit. Reinf. active minus inactive responses	0.2	0.4	1.0	-0.4	-0.7	0.0	-0.6	1.0
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	0.3	-0.0	-0.7	-0.2	0.4
Condit. Reinf. active responses	1.3	1.9	3.2	-1.1	-1.5	1.1	-1.2	1.8
Condit. Reinf. inactive responses	1.7	2.5	4.0	-1.2	-1.6	2.0	-1.1	1.8
Condit. Reinf. lever presses	2.1	3.1	4.8	-2.2	-2.0	1.4	-1.4	1.6
Condit. Reinf. lever reinforcers received	1.5	2.1	3.2	-1.3	-1.6	1.2	-1.2	1.8
Conditioned reinforcement - actives	0.1	0.3	0.5	0.1	0.3	-0.7	0.5	-0.6
Conditioned reinforcement - inactives	0.6	1.7	3.2	1.6	1.3	-1.8	1.0	-0.3
Conditioned locomotion	4.9	7.3	10.8	3.3	2.7	-3.0	2.5	-1.8
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.1	-0.3	0.2	-0.4	0.4
Patch foraging indifference point AUC	0.4	0.9	2.8	-1.7	-0.9	0.5	-0.7	0.4
Delay disc. indifference point, 0s delay	0.2	0.3	0.6	0.7	-0.1	0.8	0.1	0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	0.4	-0.1	-0.1	-0.4	0.6
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	0.2	-0.2	0.2	-0.1	0.4
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	0.5	0.5	-0.0	0.4	-0.5
Delay disc. indifference point, 4s delay	0.2	0.3	0.9	0.3	-0.3	0.9	-0.2	0.5
Delay disc. indifference point, 8s delay	0.1	0.2	0.7	0.1	-0.4	0.8	-0.2	0.5
Indifference point function ln k	2.4	7.3	13.6	3.7	2.8	-2.2	2.7	-1.8
Indifference point function log k	2.4	7.3	13.6	3.7	2.8	-2.2	2.7	-1.8
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.1	0.1	0.0	0.1	-0.1
Patch foraging total patch changes 12 sec	3.2	4.3	7.1	-2.7	-2.2	2.1	-1.9	1.3
Patch foraging total patch changes 18 sec	0.5	1.2	1.5	-1.2	-1.1	1.0	-1.2	1.0
Patch foraging total patch changes 24 sec	0.2	0.7	1.8	-1.4	-0.8	0.8	-0.5	0.2
Patch foraging total patch changes 6 sec	1.3	2.2	2.8	-1.7	-1.5	1.5	-1.3	1.3
Patch foraging time to switch 0 sec	1.8	7.1	8.8	-2.6	-2.8	2.6	-3.0	2.3
Patch foraging water rate 0 sec	2.9	11.0	12.1	3.4	3.5	-3.4	3.4	-2.9
Patch foraging water rate 12 sec	4.2	16.8	22.4	4.7	4.3	-3.5	4.4	-3.3
Patch foraging water rate 18 sec	2.0	4.4	6.5	2.6	2.2	-1.7	2.2	-1.6
Patch foraging water rate 24 sec	6.5	9.2	11.2	3.3	3.3	-2.9	2.9	-2.7
Patch foraging water rate 6 sec	6.5	9.6	11.8	3.3	3.2	-2.6	3.4	-2.8
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	0.9	-0.2	-0.8	1.0	-0.7	0.9
Distance traveled before self-admin	0.5	1.2	1.6	-1.1	-1.1	0.8	-1.1	1.3
Distance traveled after self-admin	0.2	0.3	0.7	-0.6	-0.5	0.1	-0.4	0.9
Extensor digitorum longus weight	3.2	13.0	27.8	-5.3	-3.8	3.5	-2.7	1.6
Bone: elastic displacement	2.4	3.0	3.7	1.6	1.9	-1.6	1.9	-1.7
Bone: elastic work	0.1	0.1	0.2	-0.5	0.2	0.1	0.4	-0.4
Bone: endosteal estimation	0.1	0.4	0.7	0.6	-0.4	0.3	-0.7	0.8
Bone: endosteal perimeter	0.3	0.8	2.2	0.4	-0.7	0.0	-1.1	1.5
Epididymis fat weight	1.3	6.7	11.1	3.3	2.6	-3.1	1.8	-1.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	-0.1	0.0	0.8	0.3	-0.2
Delta time in open arm before/after self-admin	0.1	0.2	0.3	-0.6	-0.3	-0.4	-0.4	0.3
Diff in mean of infusions in LGA sessions	0.2	0.3	0.7	-0.9	-0.4	0.3	-0.6	-0.3
Delay discount exponential model param	0.3	0.4	0.9	0.1	0.6	-0.9	0.5	-0.8
Extinction: sum of active levers before priming	2.3	3.4	4.9	-2.2	-2.0	1.8	-2.1	0.7
Active lever presses in extinction session 6	1.3	1.3	3.5	-1.9	-1.2	0.7	-1.0	0.7
Bone: final force	1.2	1.9	3.7	-1.9	-1.6	1.3	-0.9	0.8
Bone: final moment	1.1	1.8	3.4	-1.8	-1.5	1.3	-0.9	0.7
Food consumed during 24 hour testing period	0.2	0.4	0.8	0.1	0.5	-0.9	0.7	-0.6
Glucose	0.3	0.5	1.4	1.2	0.0	0.1	-0.4	1.1
Heart weight	0.6	1.0	1.7	0.5	-0.6	1.3	-1.0	1.2
Delay discount hyperbolic model param	0.3	0.4	0.8	0.1	0.6	-0.9	0.5	-0.8
Intermittent access intake day 1-15 change	0.3	1.8	3.0	1.4	1.4	-1.7	1.1	-1.1
Intermittent access intake escalation	0.3	1.7	3.1	1.2	1.4	-1.8	1.0	-1.1
Intermittent access intake escalation 2	1.2	2.0	3.9	1.3	1.5	-2.0	1.1	-1.1
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.6	0.2	0.3	-0.8	-0.0	0.1
Intermitt. access day 15 inactive lever presses	0.1	0.5	1.2	0.8	0.5	-1.1	-0.0	0.7
Intermitt. access escalation Index	0.5	1.7	3.9	2.0	1.2	-0.9	1.1	-1.0
Intermittent access day 1 total infusions	0.2	0.7	1.9	0.7	-0.6	0.4	-0.9	1.4
Intermittent access day 15 total infusions	0.7	1.6	3.5	1.9	1.2	-1.6	0.6	-0.3
Intermittent access terminal intake (last 3 days)	0.5	0.8	2.1	1.4	0.7	-1.2	0.1	0.3
Intermittent access total infusions	0.3	0.3	0.9	0.9	0.0	-0.3	-0.3	0.7
Intermittent access day 1 locomotion	0.3	0.6	1.9	0.6	-0.3	0.2	-0.7	1.4
Intermittent access day 15 total locomotion	0.2	0.9	2.2	1.5	0.7	-1.2	0.3	0.0
Intermittent access total locomotion	0.7	0.9	2.7	1.6	0.5	-1.0	-0.0	0.6
Intermittent access standard deviation	0.3	1.4	1.9	1.4	1.3	-1.3	1.1	-0.5
Left kidney weight	0.3	2.3	4.0	2.0	1.5	-1.3	1.4	-1.3
Right kidney weight	0.4	3.1	3.6	1.8	1.7	-1.7	1.8	-1.9
Cocaine induced anxiety	0.0	0.1	0.1	-0.3	-0.2	-0.2	-0.1	0.4
Post-drug Anxiety	0.3	0.3	0.9	-0.9	-0.6	0.2	-0.3	0.4
Baseline Anxiety	0.0	0.1	0.1	-0.2	-0.0	0.2	0.4	-0.3
Tail length	0.1	0.5	1.3	-0.3	0.3	0.1	1.1	-1.2
Length with tail	0.3	1.2	4.0	-2.0	-0.9	1.0	0.0	-0.5
Length without tail	0.2	1.1	3.4	-1.8	-0.9	1.1	-0.1	-0.1
Times rat made contact with spout	0.9	1.0	1.7	-0.8	-1.0	1.3	-1.1	0.8
Lifetime Intake	0.2	0.2	0.6	0.7	-0.1	0.0	-0.3	0.6
Liver weight, left	1.3	2.2	3.0	1.7	1.6	-1.1	1.5	-1.4
Liver weight, right	1.5	2.7	5.1	2.3	1.8	-1.1	1.6	-1.2
Locomotor activity	2.5	4.0	5.2	2.3	2.1	-1.5	2.3	-1.6
Locomotor testing distance	2.0	4.9	7.0	2.6	2.4	-1.6	2.6	-1.7
Locomotor testing rearing	0.6	2.0	4.5	2.1	1.5	-0.9	1.6	-0.5
Locomotion in novel chamber	2.8	3.7	6.8	2.6	1.9	-2.1	1.7	-0.9
Locomotion in novel chamber post-restriction	0.7	2.0	3.6	1.9	1.4	-1.6	1.0	-0.8
Fecal boli incidents, locomotor time 1	0.1	0.2	0.5	-0.2	0.1	-0.7	-0.4	0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	1.0	0.0	-0.4	1.0	-0.2	0.2
Time >=10cm from walls, locomotor time 1	0.6	0.8	2.0	-0.1	-0.8	0.3	-1.1	1.4
Bouts of movement, locomotor time 1	0.5	0.7	1.6	-1.3	-0.8	0.4	-1.0	0.4
Total resting periods, locomotor time 1	0.6	0.7	1.3	-1.2	-0.8	0.3	-1.1	0.5
Rest time, locomotor task time 1	1.2	1.9	3.1	1.5	1.4	-1.8	1.3	-0.8
Distance moved, locomotor task time 1	0.5	1.4	2.1	-0.9	-1.2	1.5	-1.1	1.2
Vertical activity count, locomotor time 1	0.0	0.3	0.8	0.9	0.6	-0.2	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	-0.2	-0.2	-0.3	-0.4	0.2
Bouts of movement, locomotor time 2	0.2	0.7	1.0	-0.9	-0.8	0.7	-1.0	0.8
Total resting periods, locomotor time 2	0.1	0.6	0.8	-0.7	-0.7	0.5	-0.9	0.8
Rest time, locomotor task time 2	1.0	1.7	3.1	1.8	1.3	-1.3	1.3	-0.5
Distance moved, locomotor task time 2	0.4	0.6	1.4	-1.2	-0.8	0.8	-0.5	0.0
Vertical activity count, locomotor time 2	0.5	1.1	2.6	0.5	1.0	-0.6	1.2	-1.6
Light reinforcement 1	0.0	0.2	0.3	0.6	0.4	-0.1	0.6	-0.3
Light reinforcement 2	0.3	0.7	1.7	0.9	0.8	-1.3	0.6	-0.4
Bone: marrow area	0.1	0.4	0.7	0.6	-0.4	0.3	-0.7	0.8
Bone: maximum diameter	0.1	0.1	0.3	-0.5	-0.3	-0.5	-0.2	-0.3
Bone: maximum force	3.2	6.4	8.7	-3.0	-2.8	2.1	-2.5	2.3
Bone: maximum moment	3.1	5.9	7.9	-2.8	-2.7	2.1	-2.3	2.1
Mean time between licks in bursts	0.0	0.1	0.3	-0.2	-0.1	0.6	0.1	-0.1
Mean num. licks in bursts	0.0	0.1	0.3	0.5	0.2	0.2	0.1	-0.0
Cd content in liver	0.4	0.4	0.9	1.0	0.6	-0.8	0.2	-0.2
Co content in liver	4.0	4.7	6.4	2.2	2.4	-1.8	2.5	-1.9
Cu content in liver	0.2	0.3	0.5	-0.3	-0.5	0.7	-0.3	0.6
Fe content in liver	0.0	0.0	0.0	-0.1	0.1	-0.0	0.2	-0.2
K content in liver	1.0	1.0	1.3	-0.9	-1.0	1.1	-0.9	0.9
Mg content in liver	0.1	0.2	0.6	0.3	-0.1	0.3	-0.2	0.7
Mn content in liver	2.3	2.6	5.3	-2.3	-1.7	1.0	-1.6	1.2
Na content in liver	0.3	0.3	0.7	-0.2	0.3	-0.7	0.4	-0.8
Rb content in liver	0.4	0.4	1.4	1.2	0.5	-0.0	0.3	0.6
Se content in liver	0.1	0.1	0.1	-0.1	-0.2	-0.2	-0.3	0.4
Sr content in liver	0.4	0.3	1.3	-1.1	-0.4	0.2	-0.2	-0.4
Zn content in liver	0.2	0.2	0.5	-0.5	-0.5	0.7	-0.3	0.1
Bone: minimum diameter	0.7	1.4	3.0	-0.0	-1.0	0.8	-1.5	1.7
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.0	-0.3	0.0	-0.5	0.7
Time in novel zone, hab. session 1	0.8	0.9	1.4	0.9	1.0	-0.5	1.2	-1.0
Total zone transitions, hab. session 1	0.7	1.0	1.5	-1.2	-1.1	1.0	-0.9	0.6
Total locomotion distance, hab. session 1	0.0	0.1	0.2	0.4	0.2	-0.2	-0.2	0.0
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.0	-0.2	0.2	-0.4	0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.3	0.5	-0.1	0.5	-0.3
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.5	-0.8	0.7	-0.6	0.7
Total zone transitions, hab. session 2	6.2	7.9	9.4	-2.2	-2.9	3.1	-2.8	3.0
Total locomotion distance, hab. session 2	1.5	1.9	3.2	-0.5	-1.3	1.5	-1.5	1.8
Locomotion velocity, hab. session 2	1.2	1.7	2.9	-0.4	-1.1	1.3	-1.5	1.7
Novel to familiar place preference ratio	1.0	1.3	2.1	-1.4	-1.2	0.5	-1.4	0.9
Novelty place preference	0.7	0.9	1.7	-1.0	-1.0	0.3	-1.3	0.8
Time in novel zone, NPP test	0.6	0.7	1.2	-0.9	-0.9	0.3	-1.1	0.7
Total zone transitions, NPP test	2.5	3.7	4.7	-2.0	-2.1	2.2	-1.6	1.6
Total locomotion distance, NPP test	0.3	0.4	0.8	-0.3	-0.7	0.9	-0.5	0.6
Locomotion velocity, NPP test	0.3	0.4	0.7	-0.4	-0.7	0.8	-0.6	0.6
Intraocular pressure	1.4	2.3	4.5	1.3	1.6	-2.1	1.2	-1.2
Delta distance traveled before/after self-admin	0.4	0.5	0.6	0.6	0.7	-0.5	0.8	-0.7
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	0.4	0.6	-0.3	0.7	-0.5
Parametrial fat weight	1.3	3.1	7.0	2.6	1.8	-1.8	1.3	-0.6
Pavlov. Cond. lever latency	0.3	0.3	0.4	0.6	0.6	-0.6	0.6	-0.5
Pavlov. Cond. magazine entry latency	1.0	1.3	1.6	-1.0	-1.2	0.9	-1.3	1.2
Pavlov. Cond. change in total contacts	0.4	0.4	0.9	-0.8	-0.7	0.1	-0.9	0.5
Pavlov. Cond. index score	0.1	0.2	0.3	-0.6	-0.5	0.1	-0.5	0.3
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.5	-0.5	0.2	-0.5	0.4
Pavlov. Cond. lever contacts	0.1	0.2	0.2	-0.4	-0.5	0.5	-0.4	0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.7	0.4	0.1	0.3	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.5	0.7	0.6	0.7	-0.8	0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.8	-0.7	0.3	-0.7	0.4
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.5	-0.3	-0.1	-0.2	-0.0
Pavlov. Cond. lever latency	0.2	0.2	0.8	0.9	0.6	-0.2	-0.0	-0.2
Pavlov. Cond. magazine entry latency	4.6	6.5	9.1	-3.0	-2.8	2.4	-2.4	2.2
Pavlov. Cond. change in total contacts	1.3	3.1	4.8	-2.2	-2.0	1.1	-1.6	1.7
Pavlov. Cond. index score	2.1	3.3	5.5	-2.3	-2.1	1.5	-1.5	1.5
Pavlov. Cond. latency score	1.7	2.7	4.7	-2.2	-1.9	1.3	-1.4	1.3
Pavlov. Cond. lever contacts	0.2	0.4	1.0	-1.0	-0.7	0.3	-0.2	0.4
Pavlov. Cond. magazine entry number	6.6	8.5	13.2	3.6	3.2	-2.6	2.6	-2.4
Pavlov. Cond. intertrial magazine entries	0.5	1.1	1.8	1.4	1.1	-1.1	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	2.6	4.0	6.5	-2.6	-2.2	1.6	-1.7	1.7
Pavlov. Cond. response bias	1.9	2.6	4.3	-2.1	-1.8	1.4	-1.2	1.4
Time in closed arm before self-admin	0.1	0.2	0.5	0.1	-0.2	-0.3	-0.4	0.7
Time in closed arm after self-admin	0.0	0.0	0.1	0.3	0.1	-0.1	0.0	-0.1
Time in open arm before self-admin	0.6	0.7	1.2	1.0	0.8	0.2	1.1	-0.9
Time in open arm after self-admin	0.0	0.0	0.1	0.0	0.2	0.0	0.2	0.1
Bone: periosteal estimation	0.1	0.1	0.3	-0.3	-0.5	0.1	-0.5	0.2
Bone: periosteal perimeter	0.4	0.8	1.2	-0.9	-1.1	0.5	-1.0	1.0
Bone: post-yield work	6.7	11.6	18.4	-2.6	-3.6	2.8	-4.3	3.5
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.0	-0.2	0.2	-0.2	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.3	0.1
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.3	-0.0	-0.1	0.0	-0.2	0.5
Progressive ratio test 2 active lever presses	0.2	0.3	0.9	0.9	0.4	-0.7	0.2	0.3
Progressive ratio test 2 breakpoint	0.3	0.4	0.9	0.9	0.5	-0.8	0.2	0.2
Progressive ratio test 2 inactive lever presses	0.8	2.6	6.1	2.5	1.5	-1.9	1.1	-0.1
Incentive Sensitization - Responses	0.3	0.8	1.6	-0.6	-0.8	0.6	-0.9	1.2
Incentive Sensitization - Breakpoint	0.2	0.5	1.3	-0.4	-0.7	0.4	-0.8	1.2
Sum of active levers in priming session hrs 5-6	1.0	1.0	2.0	-0.7	0.5	-1.4	0.7	-1.3
Progressive ratio	1.8	5.4	6.9	-1.9	-2.5	2.6	-2.6	2.0
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.3	-0.2	0.5	-0.1	0.5
Seeking ratio, punishment vs. effort	1.8	3.9	5.3	2.0	2.2	-1.9	2.3	-1.5
Retroperitoneal fat weight	4.5	20.1	40.3	6.4	4.6	-4.4	3.7	-2.4
Reaction time number correct	0.1	0.3	0.5	-0.1	0.4	-0.4	0.7	-0.7
Reaction time mean minus median	0.5	3.2	6.1	-2.5	-1.9	1.3	-1.9	1.1
Reaction time mean minus median AUC	0.1	0.8	2.3	-1.5	-0.9	0.5	-0.9	0.2
Reaction time num false alarms	0.7	1.2	1.7	1.0	1.2	-0.7	1.3	-1.2
Reaction time num false alarms AUC	0.2	0.3	0.6	0.3	0.6	-0.2	0.8	-0.8
Reaction time trials correct on left	0.1	0.3	0.5	-0.1	0.4	-0.4	0.7	-0.7
Reaction time trials on left	0.1	0.3	0.5	-0.1	0.4	-0.4	0.7	-0.7
Reaction time mean	0.0	0.1	0.1	-0.3	-0.3	0.1	-0.3	0.2
Reaction time mean AUC	0.0	0.1	0.2	-0.3	-0.3	0.1	-0.5	0.2
Median of all reaction times	0.0	0.0	0.0	0.2	0.0	-0.1	-0.0	0.2
Reaction time omissions	0.8	1.3	3.0	-1.7	-1.2	0.8	-1.0	0.6
Reaction time false alarm rate	0.2	0.3	0.4	0.6	0.6	-0.2	0.6	-0.6
Reaction time premature initiation rate	0.7	1.2	2.5	-1.4	-1.0	1.6	-0.5	0.4
Reaction time premature initiations	0.3	1.0	2.5	-1.6	-0.8	1.3	-0.1	-0.1
Std. dev. reaction times	0.3	0.9	1.7	-1.3	-1.0	0.6	-0.9	0.5
Reaction time trials completed	0.1	0.3	0.5	-0.1	0.4	-0.4	0.7	-0.7
Reaction time trials AUC	0.1	0.3	0.5	-0.0	0.4	-0.4	0.7	-0.7
Run reversals in cocaine runway, females	1.3	1.4	3.0	-0.8	-1.1	1.7	-1.0	1.2
Run reversals in cocaine runway, males	2.5	2.7	3.8	1.2	1.8	-1.8	2.0	-1.3
Latency to leave start box in cocaine runway	0.6	0.9	1.6	-0.5	-0.9	0.5	-1.3	1.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.9	-0.3	-0.7	0.5	-0.9	0.9
Latency to leave start box in cocaine runway, M	0.3	0.3	0.5	-0.6	-0.6	0.2	-0.7	0.6
Std. dev. time between licks in bursts	0.5	0.9	1.7	0.8	0.9	-0.2	1.3	-1.1
Total sessions with >9 infusions	0.9	1.1	1.7	-0.7	-1.2	1.3	-1.1	0.8
Short access day 1 total inactive lever presses	0.5	1.0	2.4	1.5	1.0	-0.9	0.9	-0.4
Short access day 10 total inactive lever presses	0.0	0.2	0.4	0.6	0.5	-0.5	0.2	0.5
Short access day 1 total infusions	0.1	0.1	0.6	0.8	0.0	-0.1	-0.2	0.3
Short access day 10 total infusions	1.6	2.7	3.8	-0.8	-1.7	1.7	-1.9	1.9
Short access total infusions	0.6	0.8	1.2	-0.2	-1.0	1.1	-1.0	0.9
Short access day 1 locomotion	0.1	0.2	0.3	0.5	-0.1	-0.0	-0.4	0.6
Short access day 10 total locomotion	0.1	0.4	1.2	0.3	-0.3	0.2	-0.7	1.1
Short access total locomotion	0.2	0.3	0.7	0.5	-0.2	0.1	-0.5	0.9
One hour access (0.3 mA shock)	1.9	2.3	5.2	2.3	1.5	-1.6	1.0	-0.3
Compulsive drug intake	0.2	0.3	0.6	-0.5	0.1	0.8	0.7	-0.6
One hour access (shock baseline)	0.9	2.3	4.8	2.2	1.4	-2.0	0.7	-0.1
Social response proportion	1.0	1.3	1.5	-1.2	-1.1	0.9	-1.2	1.2
Social responses	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.1	0.3
Social time	0.0	0.1	0.1	-0.4	-0.1	0.3	0.2	-0.2
Soleus weight	3.4	10.0	16.4	4.1	3.4	-2.9	2.9	-2.3
Bone: stiffness	3.2	5.7	7.0	-2.6	-2.6	2.0	-2.4	2.2
Tibialis anterior weight	2.4	8.2	25.1	-5.0	-2.8	2.4	-1.4	0.1
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.1	-0.6	-0.8	0.8	-0.9	1.0
Time to tail flick, vehicle, after self-admin	1.2	2.5	4.0	-1.1	-1.6	2.0	-1.7	1.4
Time to tail flick, test, before self-admin	0.4	0.5	1.3	0.8	-0.1	0.6	-0.2	1.1
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	1.6	-0.9	-1.0	1.3	-1.0	1.1
Delta time to tail flick, test, before/after SA	1.0	1.2	3.2	-0.5	0.6	-1.2	0.7	-1.8
Tibia length	0.3	0.7	1.9	-1.4	-0.5	-0.2	-0.2	-1.2
Ambulatory time before self-admin	0.5	1.5	2.2	-1.2	-1.3	0.6	-1.4	1.5
Ambulatory time after self-admin	0.2	0.4	1.2	-0.1	-0.4	-0.2	-0.6	1.1
Bone: tissue strength	0.2	0.2	0.3	-0.3	-0.4	0.3	-0.5	0.5
Total heroin consumption	2.5	2.9	6.0	-2.5	-1.8	1.6	-1.6	0.5
Bone: trabecular number	2.7	5.1	6.4	-2.1	-2.5	2.3	-2.3	2.0
Bone: trabecular spacing	0.7	1.0	1.5	1.2	1.2	-0.7	1.2	-0.7
Bone: trabecular thickness	0.4	0.5	0.8	-0.2	-0.8	0.7	-0.9	0.7
Bone: trabecular tissue density	4.0	7.0	8.5	2.8	2.7	-2.9	2.5	-2.2
Water consumed over 24 hours	0.4	0.8	1.2	-1.1	-0.9	1.1	-0.6	0.6
Number of responses in last shaping day	0.1	0.1	0.4	0.3	0.4	-0.2	0.6	0.1