Rin1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	XM_039093805.1	0.02	0.02	7.4e-03	0.01	0.02	0	0.01	1.9e-02	4.4e-03	2.1e-01	3.1e-02
2	BLA	gene expression	Rin1	0.16	0.09	4.4e-07	0.13	0.13	0.14	0.13	1.5e-07	1.9e-07	8.2e-08	1.8e-07
3	PL	gene expression	Rin1	0.12	0.06	1.9e-11	0.07	0.1	0.08	0.09	4.9e-08	1.7e-11	6.4e-09	9.3e-10
4	Brain	gene expression	Rin1	0.31	0.14	0.0e+00	0.21	0.21	0.21	0.2	5.3e-19	5.3e-19	6.2e-19	2.3e-18
5	NAcc	gene expression	Rin1	0.13	0.08	1.5e-09	0.08	0.07	0.08	0.07	2.3e-09	9.3e-09	2.9e-09	4.7e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.4	4.1	7.4	1.3	1.7	-2.4	2.7	1.6
Area under the delay curve	0.4	0.4	1.2	-0.1	-0.0	-0.7	0.7	1.1
BMI with tail	4.9	15.7	22.0	3.7	3.5	-4.7	3.6	4.2
BMI without tail	1.8	3.7	5.4	1.9	1.7	-2.3	1.7	2.0
Body weight	2.9	12.0	19.8	4.5	4.2	-3.6	2.1	2.2
Weight adjusted by age	1.2	1.3	3.1	1.8	1.5	-1.0	0.4	0.3
Bone surface	6.1	10.7	12.7	3.1	3.5	-3.6	3.5	2.6
Bone volume	3.5	6.0	9.2	1.9	2.4	-2.8	3.0	1.8
Breakpoint value in progressive ratio session	2.2	2.4	4.4	2.1	2.1	-1.5	1.0	0.3
Number of licking bursts	0.3	0.4	0.6	0.6	0.8	-0.6	0.6	0.3
Context. condit. distance diff. score	1.2	1.4	2.7	-1.6	-1.6	1.1	-0.6	-0.5
Locomotion velocity, session 1	0.3	0.3	1.0	-0.1	-0.4	0.5	-1.0	-0.4
Locomotion distance, session 1	1.5	1.9	2.8	1.1	1.1	-1.7	1.2	1.6
Locomotion velocity, session 2	2.2	2.6	4.3	2.1	1.9	-1.7	1.0	1.1
Locomotion distance, session 2	1.3	1.8	2.5	1.4	1.3	-1.6	0.9	1.5
Locomotion velocity, session 3	0.2	0.3	0.8	0.0	-0.0	-0.5	0.4	0.9
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	-0.1	0.0	0.0	0.2
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	-0.7	-0.7	-0.0	0.1	0.6
Stereotopy head waving duration, day 3	0.3	0.4	1.0	-1.0	-0.9	0.2	0.1	0.4
Locomotion velocity, session 7	0.3	0.4	1.1	-0.1	-0.2	-0.6	0.6	1.0
Locomotion distance, session 7	0.1	0.1	0.4	0.2	-0.1	-0.4	-0.1	0.6
Stereotopy head waving bouts, day 7	0.4	0.5	1.5	-0.3	0.1	-0.4	1.2	0.8
Stereotopy head waving duration, day 7	2.6	3.1	4.7	1.3	1.7	-1.8	2.2	1.7
Locomotion velocity, session 8	0.3	0.4	1.1	1.0	0.8	-0.4	-0.2	0.2
Locomotion distance, session 8	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.1	0.3
Degree of sensitization distance	0.2	0.2	0.6	0.3	0.1	-0.6	0.3	0.8
Degree of sensitization stereotypy	1.2	1.3	2.4	0.8	1.2	-1.1	1.6	0.9
Conditioned locomotion	0.6	0.7	1.8	1.4	1.1	-0.3	-0.3	-0.5
Cocaine response after cond. corrected	0.9	1.1	1.8	-1.2	-1.3	1.0	-0.8	-0.5
Cocaine response after cond. not corrected	0.5	0.5	1.1	-1.1	-1.0	0.7	-0.4	-0.0
Cocaine response before conditioning	0.9	1.1	1.5	0.9	1.2	-1.0	1.1	0.8
Saline control response	2.8	3.6	6.2	2.5	2.3	-2.0	1.1	1.2
Bone: connectivity density	4.6	7.3	9.8	2.4	2.7	-3.1	3.0	2.1
Bone: cortical apparent density	0.1	0.1	0.2	0.5	0.3	-0.0	-0.2	0.0
Bone: cortical area	0.3	0.5	1.0	1.0	1.0	-0.3	0.1	-0.7
Bone: cortical porosity	0.5	0.6	0.9	0.5	0.6	-1.0	0.9	0.6
Bone: cortical porosity	0.7	0.8	1.3	0.9	0.9	-1.1	0.8	0.5
Bone: cortical thickness	1.1	1.9	4.5	2.1	1.7	-0.2	-0.8	-1.1
Bone: cortical thickness	0.5	0.6	1.3	0.8	0.4	0.4	-1.2	-0.7
Bone: cortical tissue density	0.1	0.1	0.3	0.6	0.4	-0.1	-0.2	0.1
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	0.6	0.9	-0.8	0.8	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.2	0.6	-0.4	0.6	0.4
Condit. Reinf. active responses	0.3	0.3	0.5	0.5	0.7	-0.6	0.6	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	0.1	-0.2	0.2	0.2
Incentive salience index mean	0.7	0.9	1.1	0.8	1.0	-1.1	0.9	0.9
Condit. Reinf. lever presses	0.3	0.4	0.8	0.7	0.9	-0.6	0.5	0.1
Condit. Reinf. active minus inactive responses	0.3	0.4	1.3	-0.3	0.2	-0.5	1.1	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	-0.8	-0.4	0.1	0.6	-0.0
Condit. Reinf. active responses	1.2	1.7	3.3	0.5	0.9	-1.4	1.8	1.5
Condit. Reinf. inactive responses	1.8	2.2	3.4	1.0	1.2	-1.6	1.6	1.8
Condit. Reinf. lever presses	2.9	3.9	5.9	2.0	2.4	-2.0	2.0	1.1
Condit. Reinf. lever reinforcers received	1.5	2.0	3.7	0.8	1.2	-1.5	1.9	1.4
Conditioned reinforcement - actives	0.4	0.4	0.7	-0.6	-0.4	0.6	-0.5	-0.8
Conditioned reinforcement - inactives	3.3	3.7	7.9	-2.8	-2.3	2.0	-0.9	-0.9
Conditioned locomotion	7.5	9.0	13.0	-3.6	-3.5	3.1	-2.3	-2.3
Patch foraging indifference point 0 sec	0.1	0.1	0.3	-0.2	-0.1	-0.2	0.5	0.3
Patch foraging indifference point AUC	1.9	2.2	4.6	2.2	1.9	-1.3	0.8	0.5
Delay disc. indifference point, 0s delay	0.3	0.3	0.7	-0.6	-0.9	-0.1	0.0	0.6
Delay disc. indifference point, 16s delay	0.5	0.5	1.3	-0.8	-0.3	-0.2	1.1	0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.3	-0.3	-0.1	-0.0	0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.3	-0.3	0.5	-0.2	-0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.5	-0.3	-0.3	-0.2	0.1	0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.1	-0.2	-0.4	0.1	0.6
Indifference point function ln k	6.3	8.8	14.3	-3.7	-3.8	2.8	-2.3	-1.7
Indifference point function log k	6.3	8.8	14.3	-3.7	-3.8	2.8	-2.3	-1.7
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.1	-0.1
Patch foraging total patch changes 12 sec	3.8	4.9	8.2	2.9	2.6	-2.2	1.7	1.4
Patch foraging total patch changes 18 sec	0.8	1.1	1.3	1.1	1.1	-1.0	1.1	0.9
Patch foraging total patch changes 24 sec	1.1	1.3	3.1	1.8	1.5	-0.9	0.4	0.4
Patch foraging total patch changes 6 sec	1.5	2.2	2.7	1.6	1.6	-1.6	1.3	1.3
Patch foraging time to switch 0 sec	4.1	6.4	7.3	2.2	2.7	-2.7	2.7	2.3
Patch foraging water rate 0 sec	6.4	10.3	12.1	-3.2	-3.5	3.4	-2.9	-2.9
Patch foraging water rate 12 sec	11.0	16.8	21.7	-4.3	-4.7	4.3	-3.9	-3.3
Patch foraging water rate 18 sec	3.4	4.6	6.5	-2.4	-2.5	2.2	-1.9	-1.5
Patch foraging water rate 24 sec	6.4	8.9	10.6	-3.0	-3.3	3.1	-2.9	-2.6
Patch foraging water rate 6 sec	5.6	8.1	9.2	-2.8	-2.9	3.0	-2.9	-2.6
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.9	0.2	0.4	-0.8	0.6	1.0
Distance traveled before self-admin	0.3	0.3	0.4	0.7	0.6	-0.6	0.5	0.3
Distance traveled after self-admin	0.1	0.1	0.2	0.4	0.3	-0.4	0.2	0.5
Extensor digitorum longus weight	4.4	17.3	35.0	5.9	5.5	-3.9	1.9	1.6
Bone: elastic displacement	2.8	3.1	4.2	-1.2	-1.5	1.9	-2.0	-2.0
Bone: elastic work	0.4	0.6	1.3	0.9	0.3	0.3	-1.2	-0.8
Bone: endosteal estimation	0.4	0.8	1.2	-1.1	-0.8	-0.4	1.0	1.1
Bone: endosteal perimeter	0.7	1.4	2.9	-1.2	-0.6	-0.7	1.7	1.3
Epididymis fat weight	1.3	3.0	6.7	-2.6	-2.4	1.4	-0.5	-0.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.8	0.3	-0.2	0.2	-0.9	-0.2
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.0	0.1	0.1	0.3	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.3	0.6	0.6	0.8	-0.0	0.2	-0.5
Delay discount exponential model param	0.3	0.3	0.9	0.0	0.0	0.6	-0.6	-1.0
Extinction: sum of active levers before priming	4.4	4.4	6.4	2.5	2.5	-2.2	1.9	1.1
Active lever presses in extinction session 6	0.7	0.7	1.8	1.3	1.2	-0.3	-0.1	-0.4
Bone: final force	1.8	2.9	4.9	2.2	2.2	-1.7	1.1	0.8
Bone: final moment	1.5	2.5	4.4	2.1	2.0	-1.6	1.0	0.6
Food consumed during 24 hour testing period	0.1	0.2	0.6	-0.1	0.3	0.4	0.1	-0.7
Glucose	0.6	1.0	2.0	-1.4	-1.1	-0.1	0.8	0.9
Heart weight	1.3	1.8	4.3	-2.1	-1.8	1.1	-0.1	-0.3
Delay discount hyperbolic model param	0.2	0.3	0.8	0.0	-0.0	0.5	-0.5	-0.9
Intermittent access intake day 1-15 change	0.9	0.9	1.5	-0.9	-0.6	1.2	-0.8	-1.1
Intermittent access intake escalation	0.5	0.5	0.8	-0.8	-0.6	0.9	-0.5	-0.7
Intermittent access intake escalation 2	0.6	0.6	1.2	-0.6	-0.5	1.1	-0.8	-0.8
Intermitt. access day 1 inactive lever presses	0.8	0.9	2.5	-1.6	-1.0	0.9	0.0	0.1
Intermitt. access day 15 inactive lever presses	0.7	0.8	2.3	-1.5	-0.9	0.9	-0.0	0.1
Intermitt. access escalation Index	1.8	1.6	3.9	-1.7	-2.0	0.6	-0.7	-0.4
Intermittent access day 1 total infusions	1.4	1.6	4.0	-2.0	-1.4	-0.1	1.1	1.0
Intermittent access day 15 total infusions	2.6	2.9	8.1	-2.8	-2.1	1.3	-0.1	-0.4
Intermittent access terminal intake (last 3 days)	1.5	1.6	5.0	-2.2	-1.5	0.8	0.3	0.0
Intermittent access total infusions	1.0	1.1	3.1	-1.8	-1.0	0.1	0.9	0.6
Intermittent access day 1 locomotion	1.4	1.4	2.6	-1.3	-0.9	-0.5	1.3	1.6
Intermittent access day 15 total locomotion	1.4	1.5	4.4	-2.1	-1.5	0.8	0.2	-0.1
Intermittent access total locomotion	1.6	1.9	4.8	-2.2	-1.4	0.1	1.1	1.1
Intermittent access standard deviation	0.8	0.9	1.4	-1.2	-1.0	1.1	-0.7	-0.5
Left kidney weight	0.8	2.3	2.8	-1.6	-1.5	1.6	-1.2	-1.7
Right kidney weight	0.5	1.5	3.8	-1.0	-0.7	1.4	-0.6	-1.9
Cocaine induced anxiety	0.1	0.1	0.2	-0.1	0.0	0.3	-0.2	-0.4
Post-drug Anxiety	0.5	0.5	1.3	1.0	1.1	-0.1	0.0	-0.5
Baseline Anxiety	0.9	1.0	2.4	1.6	1.4	-0.6	0.2	0.0
Tail length	0.5	1.5	3.2	0.8	0.4	0.9	-1.8	-1.6
Length with tail	0.8	2.8	7.1	2.7	2.4	-0.7	-0.3	-0.6
Length without tail	1.5	3.2	6.6	2.6	2.5	-1.6	0.7	0.7
Times rat made contact with spout	0.8	0.9	1.1	0.9	1.0	-1.0	0.9	0.9
Lifetime Intake	0.8	0.9	2.5	-1.6	-1.0	-0.1	0.9	0.7
Liver weight, left	0.3	0.4	0.7	-0.4	-0.7	0.6	-0.8	-0.7
Liver weight, right	0.2	0.3	0.9	-0.3	-0.6	0.4	-0.9	-0.4
Locomotor activity	2.5	3.9	4.5	-1.9	-2.1	2.1	-2.1	-1.5
Locomotor testing distance	3.0	5.0	6.0	-2.2	-2.5	2.4	-2.4	-1.6
Locomotor testing rearing	1.3	2.0	3.6	-1.9	-1.9	1.3	-1.1	-0.4
Locomotion in novel chamber	3.0	3.7	7.2	-2.7	-2.5	1.8	-1.1	-0.8
Locomotion in novel chamber post-restriction	2.0	2.4	4.2	-2.1	-2.0	1.5	-0.8	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.2	0.9	0.1	0.5	0.0	0.9	-0.0
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.2	-0.1	-0.5	0.0	0.7
Time >=10cm from walls, locomotor time 1	1.0	1.0	2.6	-0.5	0.0	-0.8	1.6	1.2
Bouts of movement, locomotor time 1	1.2	1.3	2.9	1.2	1.7	-0.8	1.2	0.1
Total resting periods, locomotor time 1	1.1	1.3	2.5	1.0	1.6	-0.9	1.4	0.3
Rest time, locomotor task time 1	1.5	1.6	2.3	-1.5	-1.3	1.4	-0.9	-1.1
Distance moved, locomotor task time 1	0.7	0.7	1.3	0.7	0.4	-1.1	0.7	1.1
Vertical activity count, locomotor time 1	0.7	0.7	1.2	-1.1	-1.1	0.8	-0.4	-0.6
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.0	0.1	-0.2	0.5	0.1
Bouts of movement, locomotor time 2	0.6	0.7	1.1	0.9	1.0	-0.7	0.8	0.5
Total resting periods, locomotor time 2	0.5	0.5	0.7	0.7	0.8	-0.7	0.7	0.6
Rest time, locomotor task time 2	1.5	1.7	3.3	-1.8	-1.6	1.3	-0.9	-0.6
Distance moved, locomotor task time 2	0.5	0.6	1.4	1.2	0.9	-0.7	0.2	-0.0
Vertical activity count, locomotor time 2	1.0	1.1	2.2	-0.2	-0.5	1.1	-1.3	-1.5
Light reinforcement 1	0.2	0.3	0.5	-0.7	-0.7	0.6	-0.4	-0.3
Light reinforcement 2	0.7	0.9	1.8	-1.3	-0.8	1.0	0.0	-0.9
Bone: marrow area	0.4	0.8	1.3	-1.1	-0.9	-0.4	1.0	1.0
Bone: maximum diameter	0.1	0.1	0.3	0.3	0.6	-0.2	0.5	-0.3
Bone: maximum force	4.2	7.3	8.9	2.7	3.0	-2.9	2.5	2.3
Bone: maximum moment	3.6	6.3	7.6	2.6	2.8	-2.7	2.3	2.1
Mean time between licks in bursts	0.2	0.2	0.5	0.7	0.3	-0.3	-0.5	0.4
Mean num. licks in bursts	0.1	0.1	0.1	-0.4	-0.4	0.1	-0.0	0.3
Cd content in liver	1.7	1.8	2.4	-1.5	-1.4	1.5	-0.9	-1.3
Co content in liver	3.4	4.0	6.7	-1.6	-2.1	2.1	-2.6	-1.4
Cu content in liver	0.4	0.4	0.6	0.8	0.7	-0.8	0.4	0.5
Fe content in liver	0.0	0.0	0.1	0.3	0.1	0.0	-0.1	-0.3
K content in liver	3.5	3.5	4.4	1.7	2.1	-2.0	1.8	1.6
Mg content in liver	3.2	3.3	5.3	0.9	1.3	-2.0	2.1	2.3
Mn content in liver	2.7	3.1	5.3	1.9	2.3	-1.6	1.7	1.0
Na content in liver	0.3	0.4	0.7	0.8	0.8	-0.1	-0.2	-0.6
Rb content in liver	0.5	0.6	1.0	-1.0	-1.0	-0.2	0.4	1.0
Se content in liver	0.7	0.9	2.4	0.3	0.8	-0.9	1.6	0.7
Sr content in liver	0.9	0.8	1.9	1.4	1.3	-0.3	-0.1	-0.5
Zn content in liver	1.2	1.4	2.2	1.3	1.5	-1.1	1.0	0.7
Bone: minimum diameter	0.7	1.2	2.6	-0.6	-0.3	-0.9	1.6	1.5
Time in familiar zone, hab. session 1	0.2	0.2	0.5	-0.3	-0.0	-0.3	0.6	0.7
Time in novel zone, hab. session 1	1.0	0.9	1.7	-0.6	-0.9	1.0	-1.3	-0.8
Total zone transitions, hab. session 1	0.7	1.0	1.5	1.2	1.2	-1.1	0.6	0.7
Total locomotion distance, hab. session 1	0.1	0.1	0.3	-0.6	-0.6	0.2	-0.0	-0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.2	0.0
Time in familiar zone, hab. session 2	0.3	0.3	1.0	-0.1	-0.4	0.6	-1.0	-0.3
Time in novel zone, hab. session 2	0.6	0.6	1.3	0.4	0.5	-0.9	1.1	0.8
Total zone transitions, hab. session 2	4.9	6.4	9.3	1.9	2.0	-2.9	2.6	3.1
Total locomotion distance, hab. session 2	0.9	1.2	2.5	0.3	0.4	-1.2	1.3	1.6
Locomotion velocity, hab. session 2	0.8	1.0	2.1	0.1	0.2	-1.1	1.3	1.5
Novel to familiar place preference ratio	1.5	1.6	2.4	1.1	1.4	-1.3	1.5	0.8
Novelty place preference	1.0	1.0	2.0	0.7	1.0	-1.0	1.4	0.7
Time in novel zone, NPP test	0.8	0.8	1.6	0.6	0.8	-0.9	1.3	0.7
Total zone transitions, NPP test	2.3	3.3	4.3	2.0	2.0	-2.1	1.4	1.5
Total locomotion distance, NPP test	0.1	0.2	0.4	0.3	0.3	-0.7	0.4	0.5
Locomotion velocity, NPP test	0.1	0.2	0.4	0.4	0.4	-0.6	0.4	0.4
Intraocular pressure	1.3	1.7	2.9	-1.4	-1.0	1.7	-0.7	-1.5
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.3	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.0	-0.3	0.2	-0.5	0.0
Parametrial fat weight	0.8	1.5	4.0	-2.0	-1.7	0.7	0.4	-0.1
Pavlov. Cond. lever latency	0.3	0.3	0.4	-0.6	-0.6	0.6	-0.5	-0.5
Pavlov. Cond. magazine entry latency	1.0	1.3	2.4	0.5	0.9	-1.2	1.6	1.3
Pavlov. Cond. change in total contacts	0.5	0.5	1.4	0.2	0.7	-0.6	1.2	0.5
Pavlov. Cond. index score	0.1	0.2	0.3	0.3	0.5	-0.4	0.6	0.2
Pavlov. Cond. latency score	0.1	0.2	0.3	0.2	0.4	-0.4	0.5	0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.1	0.2	-0.2	0.1	0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	-0.4	-0.6	0.3	-0.6	-0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.7	-0.6	-0.6	0.8	-0.5	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	0.5	0.8	-0.6	0.7	0.4
Pavlov. Cond. response bias	0.1	0.1	0.2	0.2	0.5	-0.2	0.4	0.0
Pavlov. Cond. lever latency	0.6	0.8	1.4	-0.9	-1.2	0.9	-1.0	-0.2
Pavlov. Cond. magazine entry latency	4.7	5.5	7.4	2.5	2.7	-2.4	2.1	1.9
Pavlov. Cond. change in total contacts	3.1	4.2	5.9	1.9	2.4	-2.1	2.4	1.2
Pavlov. Cond. index score	3.1	3.9	6.0	2.1	2.4	-2.0	2.0	1.1
Pavlov. Cond. latency score	2.5	3.1	4.9	1.9	2.2	-1.8	1.8	0.9
Pavlov. Cond. lever contacts	0.3	0.5	1.0	0.8	1.0	-0.5	0.6	-0.2
Pavlov. Cond. magazine entry number	7.3	8.9	13.0	-3.3	-3.6	3.0	-2.7	-2.1
Pavlov. Cond. intertrial magazine entries	1.0	1.4	2.2	-1.5	-1.4	1.2	-0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.5	6.9	2.3	2.6	-2.2	2.1	1.3
Pavlov. Cond. response bias	1.9	2.5	4.2	1.7	2.1	-1.6	1.5	0.8
Time in closed arm before self-admin	0.2	0.2	0.4	0.1	0.4	-0.4	0.7	0.5
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	0.1	-0.1	0.0	0.2
Time in open arm before self-admin	0.5	0.6	1.1	-0.6	-1.0	0.6	-1.0	-0.5
Time in open arm after self-admin	0.5	0.5	0.7	-0.6	-0.7	0.8	-0.8	-0.7
Bone: periosteal estimation	0.1	0.1	0.4	-0.0	0.1	-0.3	0.6	0.2
Bone: periosteal perimeter	0.4	0.7	1.4	0.4	0.7	-0.9	1.2	0.6
Bone: post-yield work	7.5	10.2	18.7	1.3	2.2	-3.4	4.3	3.7
Progressive ratio test 1 active lever presses	0.9	1.0	2.6	-1.6	-1.2	0.8	-0.2	-0.3
Progressive ratio test 1 breakpoint	0.9	1.0	2.5	-1.6	-1.2	0.9	-0.3	-0.4
Progressive ratio test 1 inactive lever presses	0.3	0.4	1.0	-1.0	-0.8	0.3	0.1	0.3
Progressive ratio test 2 active lever presses	1.2	1.3	3.9	-2.0	-1.3	0.9	0.0	0.2
Progressive ratio test 2 breakpoint	2.2	2.4	5.8	-2.4	-1.9	1.5	-0.6	-0.3
Progressive ratio test 2 inactive lever presses	2.9	3.4	9.3	-3.1	-2.4	1.3	-0.1	0.3
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.4	0.0	-0.1	0.6	0.6
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.6	-0.2	0.1	0.5	0.5
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.9	0.8	0.8	0.4	-0.5	-1.4
Progressive ratio	4.1	4.7	6.9	1.9	2.0	-2.6	2.5	1.6
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.6	0.3	-0.1	-0.3	0.3
Seeking ratio, punishment vs. effort	3.2	3.9	5.8	-1.7	-1.9	2.3	-2.4	-1.4
Retroperitoneal fat weight	2.6	8.5	18.4	-4.3	-4.0	2.4	-1.0	-1.2
Reaction time number correct	0.2	0.2	0.5	0.4	0.3	0.3	-0.6	-0.7
Reaction time mean minus median	2.7	3.6	6.8	2.2	2.6	-1.7	1.7	0.8
Reaction time mean minus median AUC	0.9	1.2	3.0	1.5	1.7	-0.7	0.6	-0.1
Reaction time num false alarms	1.0	1.3	2.5	-0.5	-1.2	1.1	-1.6	-1.1
Reaction time num false alarms AUC	0.3	0.5	1.4	0.2	-0.4	0.6	-1.2	-0.7
Reaction time trials correct on left	0.2	0.2	0.5	0.4	0.3	0.3	-0.6	-0.7
Reaction time trials on left	0.2	0.3	0.5	0.5	0.3	0.4	-0.6	-0.7
Reaction time mean	0.0	0.1	0.1	0.1	0.4	-0.2	0.4	-0.0
Reaction time mean AUC	0.1	0.1	0.3	0.1	0.4	-0.2	0.5	0.1
Median of all reaction times	0.0	0.0	0.1	-0.3	-0.1	0.1	0.2	0.0
Reaction time omissions	0.8	1.1	2.4	1.5	1.5	-0.8	0.5	0.3
Reaction time false alarm rate	0.3	0.4	0.9	-0.3	-0.7	0.7	-0.9	-0.5
Reaction time premature initiation rate	0.8	1.1	2.9	1.7	1.3	-0.8	-0.3	0.5
Reaction time premature initiations	1.1	1.6	4.5	2.1	1.7	-0.7	-0.6	0.0
Std. dev. reaction times	0.7	1.0	2.1	1.1	1.5	-0.8	0.9	0.3
Reaction time trials completed	0.2	0.3	0.5	0.5	0.3	0.4	-0.6	-0.7
Reaction time trials AUC	0.2	0.2	0.5	0.3	0.2	0.4	-0.7	-0.6
Run reversals in cocaine runway, females	1.4	1.4	2.1	1.1	0.9	-1.4	0.8	1.5
Run reversals in cocaine runway, males	2.5	2.4	4.3	-0.8	-1.2	1.9	-2.1	-1.4
Latency to leave start box in cocaine runway	0.9	0.9	1.9	0.3	0.5	-0.9	1.4	1.3
Latency to leave start box in cocaine runway, F	0.5	0.5	0.9	0.3	0.4	-0.7	1.0	0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.1	0.2	-0.3	0.3	0.4
Std. dev. time between licks in bursts	1.1	1.3	3.4	-0.4	-1.1	1.0	-1.9	-0.9
Total sessions with >9 infusions	0.3	0.3	1.0	-1.0	-0.7	0.0	0.3	0.3
Short access day 1 total inactive lever presses	1.7	1.9	4.3	-2.1	-2.0	1.0	-0.5	-0.3
Short access day 10 total inactive lever presses	1.9	2.1	4.1	-2.0	-1.8	1.5	-0.9	-0.3
Short access day 1 total infusions	0.8	0.8	2.0	-1.4	-1.0	-0.2	0.8	0.7
Short access day 10 total infusions	1.6	1.8	4.0	-0.4	0.1	-1.5	2.0	1.6
Short access total infusions	0.5	0.6	1.0	-0.7	-0.4	-0.6	1.0	0.9
Short access day 1 locomotion	0.8	0.8	1.4	-1.0	-0.5	-0.4	1.1	1.2
Short access day 10 total locomotion	0.8	0.9	1.8	-0.8	-0.5	-0.6	1.1	1.3
Short access total locomotion	0.8	0.9	2.2	-0.6	-0.4	-0.6	1.1	1.5
One hour access (0.3 mA shock)	4.0	4.7	11.6	-3.4	-2.6	2.0	-0.6	-0.7
Compulsive drug intake	0.7	0.8	2.5	1.6	0.9	-0.5	-0.5	-0.1
One hour access (shock baseline)	3.2	3.7	10.4	-3.2	-2.2	1.8	-0.1	-0.6
Social response proportion	1.6	1.7	2.2	1.1	1.5	-1.3	1.4	1.2
Social responses	0.2	0.2	0.5	0.6	0.7	-0.3	0.2	0.2
Social time	0.1	0.1	0.3	0.6	0.6	-0.2	-0.0	-0.0
Soleus weight	3.5	10.3	15.6	-3.9	-4.0	3.1	-2.3	-2.4
Bone: stiffness	4.1	6.5	7.3	2.3	2.6	-2.7	2.6	2.4
Tibialis anterior weight	4.5	15.2	36.7	6.1	5.5	-2.9	0.8	0.2
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.1	0.9	0.9	-1.0	0.9	1.0
Time to tail flick, vehicle, after self-admin	1.5	1.6	2.2	1.5	1.3	-1.4	0.9	1.2
Time to tail flick, test, before self-admin	0.5	0.5	1.8	-0.4	-0.4	-0.5	0.3	1.4
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	-0.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	0.9	0.8	0.9	-0.9	0.6	1.0
Delta time to tail flick, test, before/after SA	0.9	0.8	2.5	0.6	0.6	0.7	-0.6	-1.6
Tibia length	0.4	1.1	2.1	1.4	1.5	-0.4	0.2	-1.1
Ambulatory time before self-admin	0.6	0.6	0.9	0.6	0.8	-0.6	1.0	0.7
Ambulatory time after self-admin	0.4	0.4	0.9	-0.1	0.1	-0.5	0.9	1.0
Bone: tissue strength	0.3	0.3	0.6	0.2	0.5	-0.6	0.8	0.5
Total heroin consumption	3.2	3.7	7.3	2.7	2.5	-1.8	1.3	0.6
Bone: trabecular number	2.6	4.1	7.7	1.4	1.9	-2.3	2.8	1.5
Bone: trabecular spacing	0.6	0.8	1.4	-0.7	-1.0	0.9	-1.2	-0.2
Bone: trabecular thickness	0.5	0.6	2.1	-0.3	0.1	-0.8	1.5	0.3
Bone: trabecular tissue density	3.4	4.8	7.0	-2.6	-2.5	2.3	-1.5	-1.6
Water consumed over 24 hours	0.6	0.8	1.3	1.0	1.1	-0.8	0.7	0.5
Number of responses in last shaping day	0.9	1.0	1.4	-1.2	-1.1	1.1	-1.0	-0.2