Hub : Genes

Slc25a45

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Slc25a45 0.2 0.09 6.3e-12 0.21 0.22 0.21 0.24 3.4e-11 6.4e-12 2.3e-11 3.4e-13
2 Brain gene expression Slc25a45 0.21 0.09 0.0e+00 0.2 0.2 0.19 0.2 1.5e-18 5.1e-18 7.3e-18 4.6e-18
3 NAcc intron excision ratio chr1_212598932_212602396 0.02 0.01 3.9e-03 0 0.01 0.01 0.01 1.5e-01 6.2e-03 3.4e-02 2.9e-02
4 OFC gene expression Slc25a45 0.2 0.1 1.7e-04 0.12 0.17 0.08 0.12 8.0e-04 6.9e-05 7.4e-03 8.9e-04
5 IC gene expression Slc25a45 0.19 0.1 6.7e-07 0.12 0.1 0.1 0.12 1.2e-05 6.0e-05 7.1e-05 1.4e-05
6 IL gene expression Slc25a45 0.18 0.1 2.0e-03 0.13 0.08 0.09 0.09 5.7e-04 4.7e-03 3.9e-03 2.9e-03
7 LHb gene expression Slc25a45 0.32 0.15 1.4e-06 0.21 0.18 0.14 0.18 1.1e-05 4.6e-05 4.0e-04 4.0e-05
8 NAcc gene expression Slc25a45 0.15 0.07 0.0e+00 0.22 0.22 0.22 0.22 1.5e-32 7.4e-32 8.8e-33 4.6e-33
9 PL gene expression Slc25a45 0.2 0.08 0.0e+00 0.29 0.27 0.28 0.28 1.2e-31 6.9e-30 1.4e-30 1.3e-30
10 Adipose gene expression Slc25a45 0.39 0.12 0.0e+00 0.22 0.23 0.23 0.23 1.3e-24 4.2e-25 8.1e-26 9.4e-26
11 pVTA gene expression Slc25a45 0.23 0.09 0.0e+00 0.3 0.3 0.31 0.31 1.1e-24 1.0e-24 1.4e-25 2.0e-25
12 Brain mRNA stability Slc25a45 0.05 0.04 2.5e-03 0.01 0.01 0.03 0.01 1.5e-02 1.7e-02 9.6e-04 2.2e-02
13 Liver gene expression Slc25a45 0.07 0.04 1.1e-04 0.02 0.01 0.03 0.02 3.7e-03 7.8e-03 4.4e-04 2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.71.8-1.1-0.7-1.3-1.2-1.0-0.9-0.9-0.5-0.9-0.3-0.4-0.20.6
Area under the delay curve0.10.10.30.20.20.0-0.00.20.30.30.20.00.60.1-0.40.5
BMI with tail1.75.812.4-3.1-2.6-3.5-3.3-2.8-2.6-2.6-1.8-2.3-1.3-1.3-1.60.1
BMI without tail0.82.54.1-1.8-1.5-2.0-2.0-1.9-1.7-1.7-1.2-1.6-0.7-1.0-1.8-0.4
Body weight2.912.818.3-4.3-3.8-4.2-4.2-3.9-3.8-3.8-3.4-3.8-3.1-3.2-2.5-2.0
Weight adjusted by age1.52.32.7-1.5-1.5-1.4-1.4-1.6-1.5-1.5-1.6-1.5-1.6-1.6-1.2-1.5
Bone surface4.58.113.7-3.5-3.0-3.7-3.4-3.2-3.0-3.0-2.7-3.1-2.6-2.4-1.1-0.6
Bone volume1.52.86.1-2.1-1.6-2.5-2.1-1.9-1.8-1.8-1.4-1.8-1.3-1.1-0.20.4
Breakpoint value in progressive ratio session3.44.05.2-2.1-2.2-2.2-2.1-2.3-2.2-2.2-2.0-2.0-2.1-1.8-1.5-0.9
Number of licking bursts0.30.40.8-0.8-0.6-0.8-0.7-0.9-0.8-0.8-0.6-0.6-0.6-0.6-0.3-0.1
Context. condit. distance diff. score2.32.73.61.71.71.71.61.81.91.91.71.61.81.51.11.3
Locomotion velocity, session 10.10.10.60.00.10.30.10.00.00.0-0.1-0.1-0.0-0.4-0.3-0.8
Locomotion distance, session 10.50.61.0-0.9-0.7-0.9-1.0-0.8-0.8-0.8-0.6-0.8-0.3-0.6-0.9-0.3
Locomotion velocity, session 22.83.24.5-2.1-1.8-2.0-2.1-1.9-2.0-2.0-1.7-2.0-1.5-1.7-1.3-0.8
Locomotion distance, session 20.71.01.6-1.2-1.0-1.1-1.2-1.1-1.1-1.1-0.8-1.0-0.6-0.8-1.3-0.6
Locomotion velocity, session 30.20.20.50.20.10.10.10.40.40.40.60.40.70.50.70.7
Locomotion distance, session 30.00.00.10.2-0.10.20.10.10.10.10.20.20.20.10.20.1
Stereotopy head waving bouts, day 30.70.81.40.51.00.60.51.11.01.01.00.81.20.90.70.6
Stereotopy head waving duration, day 30.81.01.60.71.20.70.71.31.11.11.00.91.21.00.80.9
Locomotion velocity, session 70.50.51.70.40.70.10.20.50.50.50.90.61.11.00.51.3
Locomotion distance, session 70.00.00.1-0.00.10.0-0.1-0.00.10.10.30.20.30.2-0.30.1
Stereotopy head waving bouts, day 70.10.10.9-0.00.2-0.3-0.00.30.20.20.20.10.30.50.51.0
Stereotopy head waving duration, day 70.60.71.7-1.0-0.8-1.3-1.1-0.7-0.8-0.8-0.8-1.0-0.6-0.5-0.50.3
Locomotion velocity, session 81.01.22.1-1.1-1.1-0.7-0.9-1.1-1.1-1.1-1.1-1.1-1.2-1.4-0.7-1.4
Locomotion distance, session 80.30.40.80.30.70.30.30.60.70.70.70.50.90.70.70.9
Degree of sensitization distance0.00.00.1-0.30.1-0.2-0.3-0.1-0.1-0.10.1-0.00.20.1-0.10.1
Degree of sensitization stereotypy0.40.41.2-0.8-0.7-1.1-0.8-0.6-0.7-0.7-0.6-0.7-0.5-0.3-0.20.5
Conditioned locomotion1.72.02.5-1.5-1.4-1.4-1.5-1.4-1.4-1.4-1.5-1.5-1.4-1.6-1.1-1.3
Cocaine response after cond. corrected1.41.72.51.41.61.51.31.41.31.31.41.41.41.10.80.3
Cocaine response after cond. not corrected1.01.21.71.21.31.31.11.11.11.11.21.21.21.00.80.3
Cocaine response before conditioning0.80.91.4-1.0-1.2-1.1-1.0-1.2-1.1-1.1-1.0-0.9-1.1-0.7-0.5-0.3
Saline control response4.66.16.7-2.6-2.6-2.2-2.5-2.5-2.5-2.5-2.5-2.5-2.5-2.6-2.1-2.4
Bone: connectivity density2.33.66.0-2.3-2.0-2.4-2.3-2.2-2.1-2.1-1.7-2.0-1.6-1.5-1.1-0.3
Bone: cortical apparent density0.10.20.9-0.1-0.3-0.0-0.1-0.3-0.2-0.2-0.5-0.3-0.5-0.4-0.9-0.5
Bone: cortical area0.81.21.9-1.2-1.3-1.3-1.2-1.4-1.3-1.3-1.0-1.1-1.1-1.00.1-0.3
Bone: cortical porosity0.20.20.3-0.5-0.4-0.6-0.6-0.4-0.4-0.4-0.3-0.5-0.2-0.3-0.40.1
Bone: cortical porosity0.60.61.0-1.0-0.8-0.9-1.0-0.7-0.8-0.8-0.7-0.9-0.6-0.7-0.7-0.2
Bone: cortical thickness3.35.46.7-2.0-2.5-1.7-2.0-2.6-2.6-2.6-2.4-2.2-2.6-2.6-2.0-2.4
Bone: cortical thickness0.70.92.1-0.5-0.9-0.1-0.5-1.0-1.0-1.0-0.8-0.7-1.0-1.2-1.2-1.5
Bone: cortical tissue density0.20.31.3-0.3-0.5-0.2-0.3-0.4-0.3-0.3-0.7-0.5-0.7-0.6-1.1-0.7
Condit. Reinf. active minus inactive responses0.10.20.5-0.4-0.4-0.4-0.5-0.3-0.4-0.4-0.3-0.4-0.2-0.2-0.7-0.1
Condit. Reinf. active-inactive response ratio0.00.00.60.00.1-0.0-0.10.1-0.1-0.1-0.2-0.1-0.0-0.0-0.7-0.1
Condit. Reinf. active responses0.10.10.3-0.2-0.2-0.4-0.3-0.2-0.3-0.30.0-0.10.10.2-0.00.5
Condit. Reinf. inactive responses0.20.21.00.00.0-0.2-0.00.1-0.0-0.00.50.30.50.61.01.0
Incentive salience index mean0.30.30.6-0.8-0.6-0.8-0.8-0.6-0.6-0.6-0.4-0.5-0.2-0.3-0.70.1
Condit. Reinf. lever presses0.40.61.4-1.1-0.9-1.2-1.0-0.9-0.8-0.8-0.6-0.7-0.5-0.4-0.00.2
Condit. Reinf. active minus inactive responses0.10.10.70.10.1-0.10.10.10.10.10.30.20.20.50.70.9
Condit. Reinf. active-inactive response ratio0.91.03.60.60.80.20.60.70.70.71.00.80.91.21.91.7
Condit. Reinf. active responses0.10.20.4-0.5-0.5-0.6-0.5-0.5-0.4-0.4-0.3-0.4-0.3-0.1-0.30.4
Condit. Reinf. inactive responses0.60.82.8-0.8-0.9-0.7-0.9-0.9-0.9-0.9-0.9-0.8-0.8-0.8-1.7-0.7
Condit. Reinf. lever presses2.12.94.4-2.0-1.9-2.1-1.9-1.9-1.9-1.9-1.7-1.7-1.7-1.3-0.6-0.4
Condit. Reinf. lever reinforcers received0.40.50.8-0.8-0.8-0.9-0.8-0.8-0.8-0.8-0.7-0.7-0.7-0.4-0.60.0
Conditioned reinforcement - actives0.00.10.6-0.20.0-0.4-0.0-0.2-0.1-0.1-0.10.1-0.20.10.80.1
Conditioned reinforcement - inactives2.63.94.82.12.01.72.11.92.02.02.02.11.72.22.11.8
Conditioned locomotion7.810.112.33.53.33.23.53.33.33.33.23.33.03.22.72.3
Patch foraging indifference point 0 sec0.00.00.10.1-0.20.10.10.10.00.00.10.30.00.3-0.10.3
Patch foraging indifference point AUC2.43.54.1-1.9-2.0-1.9-1.8-1.9-1.9-1.9-2.0-2.0-2.0-1.7-1.6-1.3
Delay disc. indifference point, 0s delay0.50.61.70.41.00.40.30.81.01.00.80.41.30.60.00.8
Delay disc. indifference point, 16s delay0.70.82.01.00.80.60.80.80.70.70.90.80.91.00.61.4
Delay disc. indifference point, 2s delay0.20.20.60.30.40.10.20.40.40.40.50.30.70.40.60.8
Delay disc. indifference point, 24s delay0.10.10.20.40.30.50.30.30.30.30.20.20.2-0.2-0.4-0.5
Delay disc. indifference point, 4s delay0.10.10.50.40.30.30.20.40.50.50.40.20.70.1-0.40.1
Delay disc. indifference point, 8s delay0.10.10.20.20.20.20.00.20.30.30.1-0.10.5-0.1-0.50.1
Indifference point function ln k6.912.114.43.83.63.83.63.63.53.53.73.83.63.23.02.4
Indifference point function log k6.912.114.43.83.63.83.63.63.53.53.73.83.63.23.02.4
Patch foraging total patch changes 0 sec0.00.00.10.1-0.20.20.10.0-0.1-0.1-0.00.2-0.20.1-0.2-0.2
Patch foraging total patch changes 12 sec5.36.98.6-2.7-2.9-2.6-2.7-2.8-2.8-2.8-2.6-2.6-2.5-2.3-2.7-1.9
Patch foraging total patch changes 18 sec0.60.91.3-1.1-1.1-1.1-1.0-1.0-1.0-1.0-0.9-1.0-0.8-0.6-0.8-0.2
Patch foraging total patch changes 24 sec1.93.23.9-1.8-1.9-1.5-1.6-1.7-1.7-1.7-1.9-1.8-2.0-1.8-1.6-2.0
Patch foraging total patch changes 6 sec1.21.82.8-1.4-1.7-1.2-1.4-1.5-1.5-1.5-1.3-1.2-1.4-1.1-1.3-1.0
Patch foraging time to switch 0 sec1.22.55.6-2.0-1.7-2.4-2.1-1.7-1.7-1.7-1.3-1.7-1.0-0.9-1.10.0
Patch foraging water rate 0 sec3.26.710.52.92.73.23.12.72.62.62.32.62.02.02.71.3
Patch foraging water rate 12 sec6.513.721.84.43.94.74.33.93.93.93.53.73.22.73.41.5
Patch foraging water rate 18 sec2.94.56.92.42.42.62.32.32.32.32.12.12.01.61.80.7
Patch foraging water rate 24 sec4.86.79.22.82.83.02.92.83.03.02.32.42.31.92.71.3
Patch foraging water rate 6 sec4.46.411.33.02.73.43.02.62.62.62.42.52.11.72.50.8
Seeking ratio, delayed vs. immediate footshock0.10.20.40.20.10.20.20.30.40.40.40.40.50.5-0.50.7
Distance traveled before self-admin0.60.71.8-1.1-0.9-1.3-1.1-0.9-0.9-0.9-0.8-0.9-0.6-0.4-0.30.4
Distance traveled after self-admin0.20.30.5-0.4-0.6-0.6-0.5-0.7-0.4-0.4-0.6-0.5-0.7-0.2-0.6-0.1
Extensor digitorum longus weight8.232.438.8-6.2-6.0-5.9-6.1-5.9-5.9-5.9-5.7-5.9-5.4-5.5-4.8-4.3
Bone: elastic displacement0.80.92.81.30.91.71.30.90.80.80.81.00.60.40.6-0.5
Bone: elastic work1.11.53.1-0.9-1.2-0.5-0.9-1.3-1.3-1.3-1.1-1.0-1.3-1.5-1.2-1.8
Bone: endosteal estimation1.02.15.10.71.30.40.71.21.31.31.61.21.71.72.22.3
Bone: endosteal perimeter1.42.97.50.91.60.40.91.31.51.51.81.41.92.02.72.7
Epididymis fat weight3.712.620.43.33.52.93.33.63.63.63.53.33.63.64.53.7
Delta time in closed arm before/after self-admin0.30.31.7-0.3-0.30.1-0.3-0.3-0.2-0.2-0.4-0.3-0.3-0.8-0.9-1.3
Delta time in open arm before/after self-admin0.20.20.5-0.5-0.5-0.7-0.4-0.5-0.5-0.5-0.5-0.4-0.6-0.10.20.4
Diff in mean of infusions in LGA sessions0.60.71.0-0.7-0.9-0.7-0.8-0.9-0.9-0.9-0.9-0.8-1.0-0.8-0.8-1.0
Delay discount exponential model param0.00.00.2-0.1-0.10.00.1-0.1-0.2-0.2-0.10.0-0.40.00.5-0.3
Extinction: sum of active levers before priming2.83.14.2-1.9-1.8-2.0-2.0-2.0-2.0-2.0-1.6-1.6-1.5-1.4-1.8-0.9
Active lever presses in extinction session 63.43.44.8-2.1-1.8-2.2-2.0-2.0-2.0-2.0-1.9-2.0-1.9-1.8-0.7-1.1
Bone: final force2.54.05.7-2.4-2.1-2.3-2.3-2.2-2.0-2.0-2.0-2.1-2.0-1.9-0.9-1.0
Bone: final moment2.33.75.2-2.3-2.0-2.2-2.2-2.1-2.0-2.0-1.9-2.1-1.9-1.9-0.9-1.0
Food consumed during 24 hour testing period0.00.10.2-0.1-0.1-0.10.0-0.1-0.2-0.2-0.3-0.3-0.4-0.30.2-0.3
Glucose2.74.26.61.72.11.51.62.02.12.12.32.02.62.31.72.2
Heart weight1.11.84.01.01.30.90.81.41.51.51.61.12.01.40.91.5
Delay discount hyperbolic model param0.00.10.2-0.1-0.10.00.1-0.2-0.2-0.2-0.20.0-0.5-0.00.3-0.4
Intermittent access intake day 1-15 change0.81.72.21.41.41.21.51.41.41.41.21.41.01.41.30.8
Intermittent access intake escalation0.71.41.81.21.21.01.31.21.31.31.01.30.81.21.30.7
Intermittent access intake escalation 21.11.31.61.11.11.01.21.21.31.30.91.20.81.21.20.8
Intermitt. access day 1 inactive lever presses0.10.20.70.60.40.40.50.50.50.50.30.40.20.5-0.9-0.5
Intermitt. access day 15 inactive lever presses1.12.33.71.61.51.21.51.51.41.41.61.71.51.91.41.6
Intermitt. access escalation Index3.24.56.22.12.22.12.02.02.02.02.22.02.42.02.22.5
Intermittent access day 1 total infusions2.64.19.11.52.01.01.51.71.71.72.21.92.52.42.43.0
Intermittent access day 15 total infusions5.07.510.12.62.82.12.72.52.52.52.92.92.83.13.22.8
Intermittent access terminal intake (last 3 days)5.06.611.42.22.61.72.32.32.22.22.72.62.73.03.43.1
Intermittent access total infusions4.14.98.21.92.31.41.91.81.81.82.42.22.52.62.92.8
Intermittent access day 1 locomotion2.22.84.41.41.81.01.41.51.51.51.91.62.02.11.62.1
Intermittent access day 15 total locomotion3.46.18.62.32.51.72.32.32.22.22.62.52.52.92.82.9
Intermittent access total locomotion7.69.115.72.63.01.92.62.82.72.73.22.93.23.63.64.0
Intermittent access standard deviation0.91.92.61.51.61.41.61.51.51.51.31.41.21.41.00.5
Left kidney weight0.83.96.11.61.91.31.52.12.12.11.91.72.22.12.32.5
Right kidney weight0.41.73.21.11.31.01.21.41.51.51.21.11.31.21.81.3
Cocaine induced anxiety0.00.10.1-0.1-0.2-0.4-0.2-0.4-0.3-0.3-0.20.0-0.20.1-0.4-0.2
Post-drug Anxiety0.91.01.5-1.0-1.2-1.1-1.0-1.2-1.1-1.1-1.0-0.7-1.0-0.9-0.7-0.8
Baseline Anxiety0.50.61.3-0.7-0.9-0.4-0.6-0.6-0.7-0.7-0.8-0.6-0.8-1.0-0.7-1.1
Tail length0.52.14.8-1.2-1.0-0.7-1.0-1.2-1.3-1.3-1.6-1.5-1.5-1.8-1.9-2.2
Length with tail2.19.211.6-3.1-2.9-2.5-2.8-3.0-3.1-3.1-3.2-3.1-3.2-3.4-2.6-3.2
Length without tail2.27.110.0-2.7-2.8-2.1-2.5-2.7-2.7-2.7-2.7-2.7-2.9-3.2-1.8-2.8
Times rat made contact with spout0.50.61.9-0.6-0.6-0.5-0.7-0.7-0.8-0.8-0.7-0.7-0.6-0.8-1.4-0.6
Lifetime Intake2.93.55.71.61.91.21.61.51.51.52.11.92.12.22.42.4
Liver weight, left0.91.52.21.21.41.41.31.31.41.41.21.11.20.91.50.5
Liver weight, right2.23.95.32.12.12.32.12.12.22.22.12.12.01.61.50.4
Locomotor activity1.93.06.02.11.82.42.11.71.71.71.71.91.51.11.20.2
Locomotor testing distance2.13.87.92.42.12.82.42.01.91.91.92.01.71.21.40.1
Locomotor testing rearing1.83.66.72.42.12.62.32.01.91.91.82.01.81.41.00.2
Locomotion in novel chamber5.77.39.02.52.72.42.72.82.82.82.72.72.72.83.02.4
Locomotion in novel chamber post-restriction2.94.85.42.32.31.92.22.12.02.02.22.22.12.32.32.3
Fecal boli incidents, locomotor time 10.10.10.8-0.2-0.1-0.5-0.10.0-0.3-0.3-0.0-0.1-0.10.30.60.9
Change in fecal boli incidents, locomotor task0.00.00.30.10.00.2-0.1-0.10.20.20.00.00.1-0.2-0.4-0.6
Time >=10cm from walls, locomotor time 11.31.35.60.30.7-0.10.40.80.90.91.10.81.21.51.82.4
Bouts of movement, locomotor time 12.02.35.3-1.3-1.5-1.2-1.2-1.4-1.2-1.2-1.9-1.6-1.6-1.5-2.3-1.3
Total resting periods, locomotor time 11.31.43.2-1.0-1.2-1.1-1.0-1.1-1.0-1.0-1.5-1.3-1.3-1.1-1.8-0.9
Rest time, locomotor task time 11.41.82.31.41.41.31.41.51.31.31.21.21.21.31.51.1
Distance moved, locomotor task time 10.10.10.3-0.5-0.3-0.5-0.5-0.5-0.3-0.30.0-0.30.0-0.1-0.10.3
Vertical activity count, locomotor time 10.51.11.41.21.11.11.11.01.01.01.21.21.01.00.90.9
Time >=10cm from walls, locomotor time 20.10.10.3-0.5-0.1-0.6-0.3-0.20.10.1-0.2-0.3-0.10.10.10.6
Bouts of movement, locomotor time 20.40.71.7-0.7-0.8-0.7-0.7-0.9-0.9-0.9-0.9-0.7-0.9-0.8-1.3-0.4
Total resting periods, locomotor time 20.20.31.0-0.4-0.5-0.5-0.5-0.6-0.6-0.6-0.6-0.4-0.5-0.4-1.0-0.0
Rest time, locomotor task time 22.63.33.71.91.91.61.71.91.91.91.71.61.91.71.91.9
Distance moved, locomotor task time 21.31.62.2-1.3-1.2-1.1-1.2-1.3-1.2-1.2-1.3-1.2-1.3-1.3-1.3-1.5
Vertical activity count, locomotor time 20.10.21.60.2-0.10.60.3-0.1-0.1-0.1-0.20.1-0.4-0.4-0.3-1.3
Light reinforcement 10.00.10.30.50.40.50.40.40.30.30.20.40.20.20.0-0.0
Light reinforcement 20.81.23.91.01.00.61.01.00.90.91.01.00.91.12.01.5
Bone: marrow area1.12.35.30.81.30.50.81.31.41.41.71.31.81.72.22.3
Bone: maximum diameter0.20.41.4-0.8-0.5-1.0-0.7-0.6-0.5-0.5-0.4-0.5-0.5-0.31.20.4
Bone: maximum force3.25.79.8-3.0-2.6-3.1-2.9-2.7-2.5-2.5-2.2-2.5-2.1-2.0-0.9-0.5
Bone: maximum moment3.05.28.8-2.8-2.5-3.0-2.8-2.6-2.4-2.4-2.1-2.4-2.0-1.9-0.9-0.5
Mean time between licks in bursts0.20.52.3-0.5-0.6-0.1-0.4-0.6-0.5-0.5-0.6-0.5-0.7-1.0-1.1-1.5
Mean num. licks in bursts0.20.30.50.70.50.70.60.70.60.60.50.50.60.4-0.3-0.0
Cd content in liver1.41.62.71.21.20.91.21.21.11.11.21.21.11.51.51.6
Co content in liver1.41.64.01.71.42.01.71.31.41.41.01.20.90.70.0-0.3
Cu content in liver0.10.10.30.2-0.0-0.1-0.0-0.1-0.1-0.10.20.20.20.4-0.50.6
Fe content in liver0.20.20.6-0.5-0.6-0.3-0.3-0.5-0.5-0.5-0.4-0.4-0.6-0.60.2-0.8
K content in liver0.40.40.7-0.8-0.7-0.8-0.9-0.7-0.7-0.7-0.4-0.6-0.4-0.5-0.3-0.0
Mg content in liver0.40.40.70.60.60.60.50.60.60.60.80.70.80.70.50.8
Mn content in liver3.64.05.1-2.3-2.2-2.2-2.1-2.1-2.2-2.2-2.0-2.1-2.1-1.9-0.9-1.1
Na content in liver0.40.50.8-0.6-0.7-0.5-0.6-0.7-0.7-0.7-0.8-0.7-0.9-0.8-0.1-0.8
Rb content in liver2.12.43.21.81.51.71.61.51.51.51.71.61.61.51.11.2
Se content in liver0.20.31.30.30.20.10.40.20.20.20.50.40.30.61.11.1
Sr content in liver2.92.53.2-1.6-1.6-1.4-1.5-1.6-1.6-1.6-1.8-1.7-1.8-1.8-1.1-1.4
Zn content in liver0.30.31.0-0.4-0.5-0.5-0.6-0.6-0.5-0.5-0.5-0.5-0.4-0.4-1.0-0.3
Bone: minimum diameter1.01.86.20.81.00.30.60.91.01.01.51.21.71.71.62.5
Time in familiar zone, hab. session 10.30.30.60.50.50.30.40.40.40.40.70.60.70.70.50.8
Time in novel zone, hab. session 10.20.20.70.50.40.80.60.50.60.60.20.40.2-0.10.1-0.6
Total zone transitions, hab. session 10.71.01.4-1.0-1.0-1.1-1.1-1.1-1.1-1.1-0.9-1.0-0.8-0.8-1.2-0.5
Total locomotion distance, hab. session 10.30.40.80.40.80.30.40.70.70.70.70.50.90.80.50.8
Locomotion velocity, hab. session 10.00.00.1-0.00.3-0.2-0.10.20.20.20.20.00.40.3-0.00.4
Time in familiar zone, hab. session 20.10.10.90.2-0.00.50.20.00.10.10.00.2-0.2-0.3-0.1-0.9
Time in novel zone, hab. session 20.10.10.3-0.4-0.2-0.5-0.4-0.2-0.2-0.2-0.2-0.40.00.0-0.40.5
Total zone transitions, hab. session 21.41.73.1-1.7-1.3-1.8-1.8-1.4-1.3-1.3-1.1-1.4-0.7-0.9-1.4-0.2
Total locomotion distance, hab. session 20.10.10.4-0.30.2-0.4-0.40.20.20.20.30.00.60.3-0.20.6
Locomotion velocity, hab. session 20.20.20.9-0.10.4-0.3-0.20.30.40.40.50.20.80.60.21.0
Novel to familiar place preference ratio1.01.12.4-1.3-1.0-1.5-1.2-1.1-1.1-1.1-1.1-1.2-1.0-0.7-0.60.0
Novelty place preference0.50.51.2-0.8-0.6-1.1-0.8-0.7-0.7-0.7-0.7-0.8-0.6-0.3-0.40.3
Time in novel zone, NPP test0.30.30.9-0.7-0.5-0.9-0.7-0.6-0.6-0.6-0.6-0.7-0.5-0.3-0.30.2
Total zone transitions, NPP test2.33.44.8-2.2-1.9-2.2-2.1-1.9-1.8-1.8-1.8-2.0-1.5-1.6-1.6-0.8
Total locomotion distance, NPP test0.10.10.2-0.4-0.2-0.5-0.5-0.2-0.1-0.1-0.1-0.30.1-0.0-0.40.3
Locomotion velocity, NPP test0.10.10.3-0.5-0.3-0.6-0.6-0.3-0.3-0.3-0.2-0.40.0-0.1-0.50.3
Intraocular pressure1.01.42.11.31.31.21.41.31.31.30.91.20.81.21.20.6
Delta distance traveled before/after self-admin0.20.20.70.70.30.80.60.30.40.40.20.4-0.00.1-0.4-0.8
Delta ambulatory time before/after self-admin0.10.21.00.50.10.60.30.10.10.1-0.10.2-0.2-0.2-0.6-1.0
Parametrial fat weight4.09.411.52.83.12.32.73.23.23.23.22.93.33.33.23.4
Pavlov. Cond. lever latency0.30.30.60.80.60.80.70.60.60.60.40.60.40.40.30.1
Pavlov. Cond. magazine entry latency0.20.31.0-0.8-0.5-1.0-0.8-0.4-0.4-0.4-0.4-0.5-0.1-0.1-0.50.6
Pavlov. Cond. change in total contacts0.20.20.9-0.5-0.2-0.8-0.5-0.3-0.3-0.3-0.2-0.3-0.10.2-0.10.9
Pavlov. Cond. index score0.20.30.6-0.7-0.5-0.8-0.6-0.5-0.4-0.4-0.5-0.5-0.4-0.3-0.30.2
Pavlov. Cond. latency score0.10.10.4-0.6-0.4-0.6-0.6-0.3-0.3-0.3-0.3-0.4-0.2-0.2-0.30.2
Pavlov. Cond. lever contacts0.10.10.3-0.5-0.4-0.5-0.5-0.4-0.3-0.3-0.2-0.3-0.1-0.1-0.10.2
Pavlov. Cond. magazine entry number0.30.40.70.70.60.80.70.60.60.60.70.60.60.40.5-0.1
Pavlov. Cond. intertrial magazine entries0.50.61.01.00.80.91.00.40.40.40.80.90.50.90.80.7
Pavlov. Cond. lever-magazine prob. diff.0.40.41.0-0.9-0.7-1.0-0.9-0.6-0.6-0.6-0.6-0.6-0.5-0.4-0.50.2
Pavlov. Cond. response bias0.20.20.5-0.6-0.6-0.7-0.6-0.6-0.5-0.5-0.5-0.5-0.5-0.3-0.30.1
Pavlov. Cond. lever latency0.60.81.41.11.01.21.01.01.01.00.91.00.90.7-0.20.1
Pavlov. Cond. magazine entry latency4.75.77.4-2.6-2.5-2.7-2.6-2.7-2.6-2.6-2.3-2.4-2.2-2.1-2.1-1.1
Pavlov. Cond. change in total contacts1.62.54.8-1.8-1.8-2.2-1.8-1.8-1.8-1.8-1.5-1.6-1.5-1.0-0.80.1
Pavlov. Cond. index score2.63.55.7-2.1-1.9-2.4-2.1-2.1-2.1-2.1-1.8-2.0-1.8-1.5-1.0-0.4
Pavlov. Cond. latency score2.22.95.0-2.0-1.8-2.2-2.0-2.0-2.0-2.0-1.7-1.8-1.6-1.3-0.8-0.3
Pavlov. Cond. lever contacts0.60.81.4-1.1-1.0-1.2-1.0-1.0-1.0-1.0-0.9-1.0-0.9-0.80.1-0.1
Pavlov. Cond. magazine entry number7.79.512.13.43.33.53.33.33.33.33.13.23.02.72.61.5
Pavlov. Cond. intertrial magazine entries1.11.61.91.31.31.21.31.31.41.41.21.31.11.21.41.0
Pavlov. Cond. lever-magazine prob. diff.3.24.36.6-2.3-2.1-2.6-2.3-2.3-2.3-2.3-2.1-2.2-2.0-1.7-1.3-0.6
Pavlov. Cond. response bias2.23.04.5-2.0-1.8-2.1-1.9-1.9-1.9-1.9-1.8-1.9-1.6-1.5-0.9-0.5
Time in closed arm before self-admin0.30.41.30.40.50.10.40.40.50.50.60.50.60.80.81.1
Time in closed arm after self-admin0.20.20.40.60.40.60.50.30.40.40.60.60.50.50.20.2
Time in open arm before self-admin0.40.51.30.60.61.10.60.70.50.50.40.40.5-0.1-0.9-1.1
Time in open arm after self-admin0.10.10.3-0.2-0.10.0-0.2-0.1-0.2-0.2-0.3-0.3-0.2-0.3-0.5-0.5
Bone: periosteal estimation0.20.42.2-0.4-0.1-0.6-0.3-0.1-0.0-0.00.30.00.30.41.51.2
Bone: periosteal perimeter0.20.30.9-0.7-0.4-0.9-0.7-0.5-0.4-0.4-0.2-0.4-0.2-0.00.80.8
Bone: post-yield work1.11.65.7-1.6-0.8-2.3-1.7-0.9-0.8-0.8-0.2-0.80.20.50.42.4
Progressive ratio test 1 active lever presses0.30.30.80.50.80.30.50.30.20.20.60.60.60.70.90.8
Progressive ratio test 1 breakpoint0.20.30.80.40.70.20.40.30.10.10.60.50.50.70.90.7
Progressive ratio test 1 inactive lever presses0.10.10.20.30.40.20.30.30.20.20.20.30.20.4-0.4-0.1
Progressive ratio test 2 active lever presses2.52.94.51.61.91.31.71.51.41.41.81.81.72.02.11.9
Progressive ratio test 2 breakpoint2.52.94.51.61.91.31.71.51.41.41.81.81.62.02.11.9
Progressive ratio test 2 inactive lever presses6.610.713.23.33.32.83.33.23.23.23.43.43.33.63.33.4
Incentive Sensitization - Responses0.10.10.8-0.20.1-0.3-0.1-0.1-0.1-0.10.30.20.30.40.70.9
Incentive Sensitization - Breakpoint0.20.21.00.00.4-0.10.10.10.10.10.50.40.40.60.81.0
Sum of active levers in priming session hrs 5-61.41.33.0-0.9-1.2-1.1-0.8-1.2-1.3-1.3-1.3-1.0-1.7-1.10.2-0.9
Progressive ratio0.81.33.6-1.7-1.1-1.9-1.7-0.9-1.0-1.0-0.9-1.2-0.4-0.6-0.70.4
Food seeking constrained by brief footshock0.10.10.4-0.2-0.3-0.0-0.2-0.3-0.4-0.4-0.3-0.2-0.4-0.4-0.5-0.6
Seeking ratio, punishment vs. effort1.21.74.81.91.32.21.81.11.21.21.21.40.80.80.5-0.5
Retroperitoneal fat weight10.143.246.86.86.86.56.66.86.86.86.86.76.86.56.25.2
Reaction time number correct0.20.51.1-0.6-0.5-0.4-0.5-0.6-0.6-0.6-0.8-0.8-0.7-0.9-0.2-1.0
Reaction time mean minus median2.04.97.4-2.6-2.3-2.7-2.5-2.3-2.2-2.2-2.2-2.3-2.1-1.8-1.9-1.4
Reaction time mean minus median AUC1.12.73.3-1.8-1.6-1.8-1.7-1.7-1.6-1.6-1.7-1.7-1.7-1.5-1.5-1.5
Reaction time num false alarms0.30.41.40.80.61.20.80.60.40.40.70.80.50.4-0.2-0.5
Reaction time num false alarms AUC0.10.21.10.1-0.10.50.1-0.1-0.2-0.20.00.2-0.1-0.2-0.9-1.0
Reaction time trials correct on left0.20.51.1-0.6-0.5-0.4-0.5-0.6-0.6-0.6-0.8-0.8-0.7-0.9-0.2-1.0
Reaction time trials on left0.30.61.4-0.7-0.6-0.5-0.6-0.7-0.8-0.8-0.9-0.9-0.8-1.1-0.3-1.2
Reaction time mean0.10.10.3-0.5-0.2-0.5-0.3-0.2-0.0-0.0-0.4-0.4-0.20.0-0.50.0
Reaction time mean AUC0.10.10.3-0.4-0.2-0.5-0.3-0.10.00.0-0.3-0.3-0.10.2-0.50.2
Median of all reaction times0.10.20.40.20.40.10.30.50.60.60.20.20.40.6-0.00.6
Reaction time omissions2.23.24.3-1.8-1.8-1.8-1.8-1.9-1.7-1.7-1.8-1.8-1.7-1.6-2.1-1.7
Reaction time false alarm rate0.20.30.80.70.50.90.60.50.40.40.70.80.50.5-0.3-0.2
Reaction time premature initiation rate2.83.95.8-1.9-2.0-1.4-1.8-1.8-1.9-1.9-2.0-1.8-1.9-2.4-2.0-2.4
Reaction time premature initiations3.66.410.2-2.3-2.4-1.8-2.2-2.3-2.5-2.5-2.6-2.5-2.6-3.1-2.5-3.2
Std. dev. reaction times0.81.52.4-1.4-1.3-1.5-1.3-1.2-1.0-1.0-1.4-1.3-1.2-0.9-1.3-0.9
Reaction time trials completed0.30.61.4-0.7-0.6-0.5-0.6-0.7-0.8-0.8-0.9-0.9-0.8-1.1-0.3-1.2
Reaction time trials AUC0.20.41.1-0.5-0.4-0.3-0.4-0.5-0.6-0.6-0.7-0.7-0.6-0.9-0.2-1.0
Run reversals in cocaine runway, females0.30.30.7-0.7-0.5-0.6-0.8-0.6-0.6-0.6-0.3-0.6-0.0-0.4-0.8-0.3
Run reversals in cocaine runway, males0.40.41.00.90.61.00.90.60.50.50.40.50.10.21.0-0.3
Latency to leave start box in cocaine runway0.20.21.10.20.1-0.10.00.00.20.20.50.40.60.70.41.0
Latency to leave start box in cocaine runway, F0.10.10.60.10.2-0.1-0.0-0.00.10.10.30.10.50.4-0.10.8
Latency to leave start box in cocaine runway, M0.10.10.3-0.1-0.4-0.3-0.3-0.4-0.2-0.20.10.1-0.10.20.50.3
Std. dev. time between licks in bursts0.10.10.80.30.20.60.30.10.20.20.10.20.0-0.4-0.2-0.9
Total sessions with >9 infusions0.20.21.2-0.20.1-0.4-0.2-0.2-0.2-0.20.3-0.00.40.40.81.1
Short access day 1 total inactive lever presses2.02.73.31.81.61.71.81.71.61.61.71.81.71.81.00.9
Short access day 10 total inactive lever presses0.30.71.21.10.81.10.90.80.80.80.70.90.70.7-0.9-0.7
Short access day 1 total infusions1.62.13.21.21.51.01.21.31.31.31.71.31.81.71.51.8
Short access day 10 total infusions0.70.94.10.30.8-0.10.20.30.20.21.10.61.31.41.22.0
Short access total infusions0.50.71.80.40.80.20.40.50.40.41.00.61.21.11.11.3
Short access day 1 locomotion1.72.12.81.41.51.11.31.31.21.21.71.51.61.71.41.6
Short access day 10 total locomotion0.81.52.90.91.30.60.91.21.11.11.31.01.51.51.11.7
Short access total locomotion1.72.04.01.21.40.91.11.31.21.21.51.31.71.71.62.0
One hour access (0.3 mA shock)7.58.610.03.03.22.73.02.93.03.03.03.03.03.03.02.5
Compulsive drug intake2.02.34.4-1.3-1.4-0.6-1.2-1.4-1.3-1.3-1.6-1.6-1.7-2.0-1.8-2.1
One hour access (shock baseline)6.49.812.33.13.32.53.13.03.03.03.33.33.23.53.33.1
Social response proportion0.70.81.2-1.0-1.1-1.0-0.9-1.0-0.8-0.8-0.9-0.9-1.1-0.8-0.6-0.4
Social responses0.30.30.8-0.5-0.5-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.7-0.7-0.6-0.9
Social time0.40.61.9-0.6-0.6-0.4-0.5-0.6-0.5-0.5-0.9-0.9-0.8-1.0-0.9-1.4
Soleus weight4.613.715.43.83.83.73.83.93.93.93.73.83.73.63.52.9
Bone: stiffness2.44.07.3-2.5-2.1-2.7-2.4-2.2-2.1-2.1-1.9-2.1-1.7-1.6-0.8-0.1
Tibialis anterior weight11.238.143.1-6.6-6.5-6.0-6.1-6.4-6.4-6.4-6.5-6.4-6.4-6.3-4.6-5.5
Time to tail flick, vehicle, before self-admin0.20.20.5-0.6-0.3-0.7-0.6-0.4-0.4-0.4-0.3-0.5-0.1-0.2-0.20.0
Time to tail flick, vehicle, after self-admin0.40.51.3-1.0-0.6-1.1-1.1-0.5-0.5-0.5-0.4-0.80.0-0.5-0.70.0
Time to tail flick, test, before self-admin2.42.54.01.41.51.31.31.71.71.71.71.52.01.61.11.7
Time to tail flick, test, after self-admin0.00.00.1-0.2-0.2-0.3-0.2-0.1-0.1-0.1-0.3-0.3-0.3-0.10.2-0.2
Delta time to tail flick, vehicle, before/after SA0.30.30.5-0.7-0.6-0.6-0.7-0.5-0.4-0.4-0.4-0.6-0.3-0.5-0.7-0.3
Delta time to tail flick, test, before/after SA2.12.24.2-1.3-1.4-1.1-1.1-1.4-1.4-1.4-1.8-1.5-2.0-1.7-0.9-1.9
Tibia length1.02.94.5-1.9-1.7-2.1-1.7-1.9-1.9-1.9-1.7-1.8-2.0-1.30.5-0.0
Ambulatory time before self-admin0.40.51.5-1.0-0.8-1.2-0.9-0.8-0.7-0.7-0.6-0.7-0.5-0.10.10.7
Ambulatory time after self-admin0.30.31.40.50.30.10.30.30.40.40.40.40.40.90.31.2
Bone: tissue strength0.00.00.0-0.2-0.1-0.2-0.1-0.1-0.0-0.0-0.0-0.10.00.0-0.00.2
Total heroin consumption5.96.97.9-2.8-2.7-2.7-2.7-2.6-2.6-2.6-2.7-2.7-2.6-2.6-2.7-2.2
Bone: trabecular number0.71.22.8-1.4-1.1-1.7-1.4-1.3-1.2-1.2-0.8-1.1-0.7-0.5-0.00.7
Bone: trabecular spacing0.50.61.31.00.91.10.90.90.80.80.60.70.70.4-0.4-0.4
Bone: trabecular thickness0.40.51.40.60.60.30.40.40.50.50.80.60.80.90.71.2
Bone: trabecular tissue density4.46.57.72.82.62.62.82.72.72.72.52.62.42.52.41.8
Water consumed over 24 hours1.11.52.3-1.0-1.2-0.9-1.1-1.2-1.2-1.2-1.3-1.3-1.3-1.4-1.5-1.1
Number of responses in last shaping day0.10.10.40.20.30.30.20.00.00.00.00.1-0.0-0.1-0.5-0.6