Hub : Genes

Slc25a45

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Slc25a45 0.2 0.09 6.3e-12 0.21 0.22 0.21 0.24 3.4e-11 6.4e-12 2.3e-11 3.3e-13
2 Brain gene expression Slc25a45 0.21 0.09 0.0e+00 0.2 0.2 0.19 0.2 1.5e-18 5.1e-18 7.4e-18 4.7e-18
3 NAcc intron excision ratio chr1_212598932_212602396 0.02 0.01 3.9e-03 0 0.01 0.01 0.01 1.5e-01 6.2e-03 3.4e-02 2.9e-02
4 OFC gene expression Slc25a45 0.2 0.1 1.7e-04 0.12 0.17 0.08 0.12 8.0e-04 6.9e-05 7.4e-03 9.9e-04
5 IC gene expression Slc25a45 0.19 0.1 6.7e-07 0.12 0.1 0.1 0.12 1.2e-05 6.0e-05 7.1e-05 1.5e-05
6 RMTg gene expression Slc25a45 0.13 0.09 9.7e-03 0.03 0.04 0.04 0.03 5.7e-02 3.3e-02 4.1e-02 5.7e-02
7 IL gene expression Slc25a45 0.18 0.1 2.0e-03 0.13 0.08 0.09 0.09 5.7e-04 4.7e-03 3.9e-03 3.0e-03
8 LHb gene expression Slc25a45 0.32 0.15 1.4e-06 0.21 0.18 0.14 0.18 1.1e-05 4.6e-05 4.0e-04 4.0e-05
9 NAcc gene expression Slc25a45 0.15 0.07 0.0e+00 0.22 0.22 0.22 0.22 1.5e-32 7.4e-32 8.8e-33 4.6e-33
10 PL gene expression Slc25a45 0.2 0.08 0.0e+00 0.29 0.27 0.28 0.28 1.2e-31 6.9e-30 1.4e-30 1.3e-30
11 Adipose gene expression Slc25a45 0.39 0.12 0.0e+00 0.22 0.23 0.23 0.23 1.3e-24 4.2e-25 8.1e-26 9.8e-26
12 pVTA gene expression Slc25a45 0.23 0.09 0.0e+00 0.3 0.3 0.31 0.31 1.1e-24 1.0e-24 1.4e-25 1.9e-25
13 Brain mRNA stability Slc25a45 0.05 0.04 2.5e-03 0.01 0.01 0.03 0.01 1.5e-02 1.7e-02 9.6e-04 2.3e-02
14 Liver gene expression Slc25a45 0.07 0.04 1.1e-04 0.02 0.01 0.03 0.02 3.7e-03 7.8e-03 4.4e-04 2.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.40.71.8-1.10.7-1.3-1.21.0-0.70.90.9-0.50.90.30.40.2-0.6
Area under the delay curve0.10.10.30.2-0.20.0-0.0-0.20.3-0.3-0.30.2-0.0-0.6-0.10.4-0.5
BMI with tail1.65.612.4-3.12.6-3.5-3.32.8-2.02.62.6-1.82.31.31.31.6-0.1
BMI without tail0.52.44.1-1.81.5-2.0-2.01.9-1.21.71.7-1.21.60.71.01.80.4
Body weight2.912.818.4-4.33.8-4.2-4.23.9-3.53.83.8-3.43.83.13.22.52.0
Weight adjusted by age0.82.32.7-1.51.5-1.4-1.41.6-1.61.51.5-1.61.51.51.61.21.5
Bone surface4.28.213.7-3.53.0-3.7-3.43.2-2.93.03.0-2.83.12.62.41.10.6
Bone volume1.42.76.1-2.11.6-2.5-2.11.9-1.61.81.8-1.41.81.31.10.2-0.4
Breakpoint value in progressive ratio session2.24.15.2-2.12.2-2.2-2.12.3-2.12.22.2-2.02.02.01.81.50.9
Number of licking bursts0.10.40.8-0.80.6-0.8-0.70.9-0.70.80.8-0.60.60.60.60.30.1
Context. condit. distance diff. score2.32.83.61.7-1.71.71.6-1.81.7-1.9-1.91.7-1.6-1.7-1.5-1.1-1.3
Locomotion velocity, session 10.10.10.60.0-0.10.30.1-0.0-0.1-0.0-0.0-0.10.10.10.40.30.8
Locomotion distance, session 10.40.61.0-0.90.7-0.9-1.00.8-0.60.80.8-0.60.80.30.60.90.3
Locomotion velocity, session 22.73.24.5-2.11.8-2.0-2.11.9-1.82.02.0-1.72.01.51.71.30.8
Locomotion distance, session 20.71.01.6-1.21.0-1.1-1.21.1-0.81.11.1-0.81.00.60.81.30.6
Locomotion velocity, session 30.20.20.60.2-0.10.10.1-0.40.5-0.4-0.40.6-0.4-0.7-0.5-0.7-0.7
Locomotion distance, session 30.00.00.10.20.10.20.1-0.10.2-0.1-0.10.2-0.2-0.1-0.1-0.2-0.1
Stereotopy head waving bouts, day 30.70.81.40.5-1.00.60.5-1.11.0-1.0-1.01.0-0.8-1.2-0.9-0.7-0.6
Stereotopy head waving duration, day 30.81.01.60.7-1.20.70.7-1.31.0-1.1-1.11.0-0.9-1.2-1.0-0.8-0.9
Locomotion velocity, session 70.50.51.70.4-0.70.10.2-0.50.8-0.5-0.50.9-0.6-1.1-1.0-0.5-1.3
Locomotion distance, session 70.00.00.1-0.0-0.10.0-0.10.00.2-0.1-0.10.3-0.2-0.3-0.20.3-0.1
Stereotopy head waving bouts, day 70.10.10.9-0.0-0.2-0.3-0.0-0.30.2-0.2-0.20.2-0.1-0.3-0.5-0.5-1.0
Stereotopy head waving duration, day 70.50.71.7-1.00.8-1.3-1.10.7-0.80.80.8-0.81.00.60.50.5-0.3
Locomotion velocity, session 81.01.22.1-1.11.1-0.7-0.91.1-1.11.11.1-1.11.11.21.40.71.4
Locomotion distance, session 80.30.40.80.3-0.70.30.3-0.60.7-0.7-0.70.7-0.5-0.9-0.7-0.7-0.9
Degree of sensitization distance0.00.00.1-0.3-0.1-0.2-0.30.10.10.10.10.10.0-0.2-0.10.1-0.1
Degree of sensitization stereotypy0.40.41.2-0.80.7-1.1-0.80.6-0.60.70.7-0.60.70.50.30.2-0.5
Conditioned locomotion1.72.02.5-1.51.4-1.4-1.51.4-1.51.41.4-1.51.51.41.61.11.3
Cocaine response after cond. corrected1.11.72.51.4-1.61.51.3-1.41.4-1.3-1.31.4-1.4-1.4-1.1-0.8-0.3
Cocaine response after cond. not corrected0.81.21.71.2-1.31.31.1-1.11.2-1.1-1.11.2-1.2-1.2-1.0-0.8-0.3
Cocaine response before conditioning0.80.91.4-1.01.2-1.1-1.01.2-1.01.11.1-1.00.91.10.70.50.3
Saline control response4.46.16.7-2.62.6-2.2-2.52.5-2.52.52.5-2.52.52.42.62.12.4
Bone: connectivity density2.23.66.0-2.32.0-2.4-2.32.2-1.92.12.1-1.72.01.61.51.10.3
Bone: cortical apparent density0.10.20.9-0.10.3-0.0-0.10.3-0.30.20.2-0.50.30.50.40.90.5
Bone: cortical area0.71.21.9-1.21.3-1.3-1.21.4-1.21.31.3-1.01.11.11.0-0.10.3
Bone: cortical porosity0.20.20.3-0.50.4-0.6-0.60.4-0.40.40.4-0.30.50.20.30.4-0.1
Bone: cortical porosity0.60.61.0-1.00.8-0.9-1.00.7-0.80.80.8-0.70.90.60.70.70.2
Bone: cortical thickness3.25.46.7-2.02.5-1.7-2.02.6-2.42.62.6-2.42.22.52.62.02.4
Bone: cortical thickness0.70.92.1-0.50.9-0.1-0.51.0-0.81.01.0-0.80.71.01.21.21.5
Bone: cortical tissue density0.20.31.3-0.30.5-0.2-0.30.4-0.50.30.3-0.70.50.70.61.10.7
Condit. Reinf. active minus inactive responses0.10.20.5-0.40.4-0.4-0.50.3-0.30.40.4-0.30.40.20.20.70.1
Condit. Reinf. active-inactive response ratio0.00.00.60.0-0.1-0.0-0.1-0.1-0.10.10.1-0.20.10.10.00.70.1
Condit. Reinf. active responses0.10.10.3-0.20.2-0.4-0.30.2-0.00.30.30.00.1-0.1-0.20.0-0.5
Condit. Reinf. inactive responses0.20.21.00.0-0.0-0.2-0.0-0.10.40.00.00.5-0.3-0.5-0.6-1.0-1.0
Incentive salience index mean0.20.30.6-0.80.6-0.8-0.80.6-0.40.60.6-0.40.50.20.30.7-0.1
Condit. Reinf. lever presses0.40.61.4-1.10.9-1.2-1.00.9-0.70.80.8-0.60.70.50.40.0-0.2
Condit. Reinf. active minus inactive responses0.10.10.70.1-0.1-0.10.1-0.10.2-0.1-0.10.3-0.2-0.2-0.5-0.7-0.9
Condit. Reinf. active-inactive response ratio0.61.03.60.6-0.80.20.6-0.70.8-0.7-0.71.0-0.8-0.9-1.2-1.9-1.7
Condit. Reinf. active responses0.10.20.4-0.50.5-0.6-0.50.5-0.30.40.4-0.30.40.30.10.3-0.4
Condit. Reinf. inactive responses0.60.82.8-0.80.9-0.7-0.90.9-0.80.90.9-0.90.80.80.81.70.7
Condit. Reinf. lever presses2.02.94.4-2.01.9-2.1-1.91.9-1.71.91.9-1.71.71.71.30.60.4
Condit. Reinf. lever reinforcers received0.40.50.8-0.80.8-0.9-0.80.8-0.70.80.8-0.70.70.70.40.6-0.0
Conditioned reinforcement - actives0.00.10.6-0.2-0.0-0.4-0.00.2-0.20.10.1-0.1-0.10.2-0.1-0.8-0.1
Conditioned reinforcement - inactives1.43.94.82.1-2.01.72.1-1.91.9-2.0-2.02.0-2.1-1.7-2.2-2.1-1.8
Conditioned locomotion6.810.112.33.5-3.33.23.5-3.33.3-3.3-3.33.2-3.3-3.0-3.2-2.7-2.3
Patch foraging indifference point 0 sec0.00.00.10.10.20.10.1-0.10.1-0.0-0.00.1-0.30.0-0.30.1-0.3
Patch foraging indifference point AUC1.53.54.1-1.92.0-1.9-1.81.9-2.01.91.9-2.02.02.01.71.61.3
Delay disc. indifference point, 0s delay0.50.61.70.4-1.00.40.3-0.80.8-1.0-1.00.8-0.4-1.3-0.6-0.0-0.8
Delay disc. indifference point, 16s delay0.60.82.01.0-0.80.60.8-0.81.0-0.7-0.70.9-0.8-0.9-1.0-0.6-1.4
Delay disc. indifference point, 2s delay0.20.20.60.3-0.40.10.2-0.40.4-0.4-0.40.5-0.3-0.7-0.4-0.6-0.8
Delay disc. indifference point, 24s delay0.10.10.20.4-0.30.50.3-0.30.2-0.3-0.30.2-0.2-0.20.20.40.5
Delay disc. indifference point, 4s delay0.10.10.50.4-0.30.30.2-0.40.4-0.5-0.50.4-0.2-0.7-0.10.4-0.1
Delay disc. indifference point, 8s delay0.00.10.20.2-0.20.20.0-0.20.2-0.3-0.30.10.1-0.50.10.5-0.1
Indifference point function ln k4.012.214.43.8-3.63.83.6-3.63.7-3.5-3.53.7-3.8-3.6-3.2-3.0-2.4
Indifference point function log k4.012.214.43.8-3.63.83.6-3.63.7-3.5-3.53.7-3.8-3.6-3.2-3.0-2.4
Patch foraging total patch changes 0 sec0.00.00.10.10.20.20.1-0.00.00.10.1-0.0-0.20.2-0.10.20.2
Patch foraging total patch changes 12 sec5.16.88.6-2.72.9-2.6-2.72.8-2.62.82.8-2.62.62.52.32.71.9
Patch foraging total patch changes 18 sec0.40.91.3-1.11.1-1.1-1.01.0-0.91.01.0-0.91.00.80.60.80.2
Patch foraging total patch changes 24 sec0.93.23.9-1.81.9-1.5-1.61.7-1.91.71.7-1.91.82.01.81.62.0
Patch foraging total patch changes 6 sec1.11.82.8-1.41.7-1.2-1.41.5-1.31.51.5-1.31.21.41.11.31.0
Patch foraging time to switch 0 sec0.72.55.6-2.01.7-2.4-2.11.7-1.41.71.7-1.31.71.00.91.1-0.0
Patch foraging water rate 0 sec1.86.610.52.9-2.73.23.1-2.72.4-2.6-2.62.3-2.6-2.0-2.0-2.7-1.3
Patch foraging water rate 12 sec3.413.621.84.4-3.94.74.3-3.93.6-3.9-3.93.6-3.7-3.2-2.7-3.4-1.5
Patch foraging water rate 18 sec2.04.56.92.4-2.42.62.3-2.32.1-2.3-2.32.1-2.1-1.9-1.6-1.8-0.7
Patch foraging water rate 24 sec4.76.79.22.8-2.83.02.9-2.82.4-3.0-3.02.3-2.4-2.3-1.9-2.7-1.3
Patch foraging water rate 6 sec4.36.311.33.0-2.73.43.0-2.62.5-2.6-2.62.4-2.5-2.2-1.7-2.5-0.8
Seeking ratio, delayed vs. immediate footshock0.10.20.40.2-0.10.20.2-0.30.5-0.4-0.40.4-0.4-0.4-0.50.5-0.7
Distance traveled before self-admin0.30.71.8-1.10.9-1.3-1.10.9-0.80.90.9-0.80.90.60.40.3-0.4
Distance traveled after self-admin0.20.30.5-0.40.6-0.6-0.50.7-0.60.40.4-0.60.50.70.20.60.1
Extensor digitorum longus weight8.132.538.9-6.26.0-5.9-6.15.9-5.85.95.9-5.75.95.45.54.84.3
Bone: elastic displacement0.70.92.81.3-0.91.71.3-0.90.8-0.8-0.80.8-1.0-0.6-0.4-0.60.5
Bone: elastic work1.11.43.1-0.91.2-0.5-0.91.3-1.11.31.3-1.11.01.21.51.21.8
Bone: endosteal estimation0.92.15.10.7-1.30.40.7-1.21.4-1.3-1.31.6-1.2-1.7-1.7-2.2-2.3
Bone: endosteal perimeter1.22.97.50.9-1.60.40.9-1.31.5-1.5-1.51.8-1.4-1.9-2.0-2.7-2.7
Epididymis fat weight2.512.520.43.3-3.52.93.3-3.63.4-3.6-3.63.5-3.3-3.6-3.6-4.5-3.7
Delta time in closed arm before/after self-admin0.30.31.7-0.30.30.1-0.30.3-0.30.20.2-0.40.30.40.80.91.3
Delta time in open arm before/after self-admin0.20.20.5-0.50.5-0.7-0.40.5-0.50.50.5-0.50.40.60.1-0.2-0.4
Diff in mean of infusions in LGA sessions0.40.71.0-0.70.9-0.7-0.80.9-0.90.90.9-0.90.81.00.80.81.0
Delay discount exponential model param0.00.00.2-0.10.10.00.10.1-0.20.20.2-0.1-0.00.4-0.0-0.50.3
Extinction: sum of active levers before priming2.03.14.2-1.91.8-2.0-2.02.0-1.72.02.0-1.61.61.51.41.80.9
Active lever presses in extinction session 63.43.44.8-2.11.8-2.2-2.02.0-2.02.02.0-1.92.01.91.80.71.1
Bone: final force2.54.05.7-2.42.1-2.3-2.32.2-2.12.02.0-2.02.12.01.90.91.0
Bone: final moment2.33.75.2-2.32.0-2.2-2.22.1-2.02.02.0-1.92.11.91.90.91.0
Food consumed during 24 hour testing period0.00.10.2-0.10.1-0.10.00.1-0.30.20.2-0.30.30.40.3-0.20.3
Glucose2.74.36.51.7-2.11.51.6-2.02.2-2.1-2.12.3-2.0-2.6-2.3-1.7-2.2
Heart weight1.11.84.01.0-1.30.90.8-1.41.5-1.5-1.51.6-1.1-2.0-1.4-0.9-1.5
Delay discount hyperbolic model param0.00.00.2-0.10.10.00.10.2-0.20.20.2-0.2-0.00.50.0-0.30.4
Intermittent access intake day 1-15 change0.31.72.21.4-1.41.21.5-1.41.3-1.4-1.41.2-1.4-1.0-1.4-1.3-0.8
Intermittent access intake escalation0.21.31.81.2-1.21.01.3-1.21.1-1.3-1.31.0-1.3-0.8-1.2-1.3-0.7
Intermittent access intake escalation 20.71.31.61.1-1.11.01.2-1.21.0-1.3-1.30.9-1.2-0.8-1.2-1.2-0.8
Intermitt. access day 1 inactive lever presses0.00.20.70.6-0.40.40.5-0.50.4-0.5-0.50.3-0.4-0.2-0.50.90.5
Intermitt. access day 15 inactive lever presses0.42.43.71.6-1.51.21.5-1.51.6-1.4-1.41.6-1.7-1.6-1.9-1.4-1.6
Intermitt. access escalation Index1.54.66.22.1-2.22.12.0-2.02.2-2.0-2.02.2-2.0-2.4-2.0-2.2-2.5
Intermittent access day 1 total infusions1.44.29.11.5-2.01.01.5-1.72.1-1.7-1.72.2-1.9-2.5-2.4-2.4-3.0
Intermittent access day 15 total infusions3.17.510.12.6-2.82.12.7-2.52.8-2.5-2.52.9-2.9-2.8-3.1-3.2-2.8
Intermittent access terminal intake (last 3 days)3.86.611.42.2-2.61.72.3-2.32.6-2.2-2.22.7-2.6-2.7-3.0-3.4-3.1
Intermittent access total infusions4.24.98.21.9-2.31.41.9-1.82.3-1.8-1.82.4-2.2-2.5-2.6-2.9-2.8
Intermittent access day 1 locomotion1.52.84.41.4-1.81.01.4-1.51.8-1.5-1.51.9-1.6-2.1-2.1-1.6-2.1
Intermittent access day 15 total locomotion1.66.18.62.3-2.51.72.3-2.32.5-2.2-2.22.6-2.5-2.5-2.9-2.8-2.9
Intermittent access total locomotion7.79.215.72.6-3.01.92.6-2.83.1-2.7-2.73.2-2.9-3.2-3.6-3.6-4.0
Intermittent access standard deviation0.41.92.61.5-1.61.41.6-1.51.4-1.5-1.51.3-1.4-1.2-1.4-1.0-0.5
Left kidney weight0.53.86.11.6-1.91.31.5-2.11.9-2.1-2.11.9-1.7-2.2-2.1-2.3-2.5
Right kidney weight0.21.73.21.1-1.31.01.2-1.41.2-1.5-1.51.2-1.1-1.3-1.2-1.8-1.3
Cocaine induced anxiety0.00.10.1-0.10.2-0.4-0.20.4-0.20.30.3-0.2-0.00.2-0.10.40.2
Post-drug Anxiety0.91.01.5-1.01.2-1.1-1.01.2-1.01.11.1-1.00.71.00.90.70.8
Baseline Anxiety0.30.61.3-0.70.9-0.4-0.60.6-0.70.70.7-0.80.60.81.00.71.1
Tail length0.42.14.8-1.21.0-0.7-1.01.2-1.51.31.3-1.61.51.51.81.92.2
Length with tail2.19.311.6-3.12.9-2.5-2.83.0-3.23.13.1-3.23.13.13.42.63.2
Length without tail1.47.110.0-2.72.8-2.1-2.52.7-2.82.72.7-2.72.72.93.21.82.8
Times rat made contact with spout0.50.61.9-0.60.6-0.5-0.70.7-0.70.80.8-0.70.70.60.81.40.6
Lifetime Intake2.93.55.71.6-1.91.21.6-1.52.0-1.5-1.52.1-1.9-2.2-2.2-2.4-2.4
Liver weight, left0.91.52.21.2-1.41.41.3-1.31.2-1.4-1.41.2-1.1-1.2-0.9-1.5-0.5
Liver weight, right2.23.95.32.1-2.12.32.1-2.12.1-2.2-2.22.1-2.1-2.0-1.6-1.5-0.4
Locomotor activity1.93.06.02.1-1.82.42.1-1.71.7-1.7-1.71.7-1.9-1.5-1.1-1.2-0.2
Locomotor testing distance1.53.87.92.4-2.12.82.4-2.02.0-1.9-1.91.9-2.0-1.7-1.2-1.4-0.1
Locomotor testing rearing1.03.66.72.4-2.12.62.3-2.02.0-1.9-1.91.8-2.0-1.8-1.4-1.0-0.2
Locomotion in novel chamber5.47.39.02.5-2.72.42.7-2.82.7-2.8-2.82.7-2.7-2.7-2.8-3.0-2.4
Locomotion in novel chamber post-restriction1.64.85.42.3-2.31.92.2-2.12.2-2.0-2.02.2-2.2-2.1-2.3-2.3-2.3
Fecal boli incidents, locomotor time 10.00.10.8-0.20.1-0.5-0.1-0.0-0.10.30.3-0.00.10.1-0.3-0.6-0.9
Change in fecal boli incidents, locomotor task0.00.00.30.1-0.00.2-0.10.10.1-0.2-0.20.0-0.0-0.10.20.40.6
Time >=10cm from walls, locomotor time 11.01.35.60.3-0.7-0.10.4-0.80.9-0.9-0.91.1-0.8-1.2-1.5-1.8-2.4
Bouts of movement, locomotor time 11.72.35.3-1.31.5-1.2-1.21.4-1.51.21.2-1.91.61.61.52.31.3
Total resting periods, locomotor time 11.21.43.2-1.01.2-1.1-1.01.1-1.21.01.0-1.51.31.31.11.80.9
Rest time, locomotor task time 11.11.82.31.4-1.41.31.4-1.51.3-1.3-1.31.2-1.2-1.3-1.3-1.5-1.1
Distance moved, locomotor task time 10.00.10.3-0.50.3-0.5-0.50.5-0.20.30.30.00.3-0.00.10.1-0.3
Vertical activity count, locomotor time 10.21.11.41.2-1.11.11.1-1.01.1-1.0-1.01.2-1.2-1.0-1.0-0.9-0.9
Time >=10cm from walls, locomotor time 20.00.10.3-0.50.1-0.6-0.30.2-0.3-0.1-0.1-0.20.30.1-0.1-0.1-0.6
Bouts of movement, locomotor time 20.20.71.7-0.70.8-0.7-0.70.9-0.80.90.9-0.90.70.90.81.30.4
Total resting periods, locomotor time 20.10.31.0-0.40.5-0.5-0.50.6-0.50.60.6-0.60.40.50.41.00.0
Rest time, locomotor task time 21.93.33.71.9-1.91.61.7-1.91.8-1.9-1.91.7-1.6-1.9-1.7-1.9-1.9
Distance moved, locomotor task time 21.21.62.2-1.31.2-1.1-1.21.3-1.31.21.2-1.31.21.31.31.31.5
Vertical activity count, locomotor time 20.10.21.60.20.10.60.30.1-0.10.10.1-0.2-0.10.40.40.31.3
Light reinforcement 10.00.10.30.5-0.40.50.4-0.40.3-0.3-0.30.2-0.4-0.2-0.2-0.00.0
Light reinforcement 20.51.23.91.0-1.00.61.0-1.00.9-0.9-0.91.0-1.0-0.9-1.1-2.0-1.5
Bone: marrow area0.92.35.30.8-1.30.50.8-1.31.5-1.4-1.41.7-1.3-1.8-1.7-2.2-2.3
Bone: maximum diameter0.20.41.4-0.80.5-1.0-0.70.6-0.60.50.5-0.40.50.50.3-1.2-0.4
Bone: maximum force2.95.79.8-3.02.6-3.1-2.92.7-2.42.52.5-2.22.52.12.00.90.5
Bone: maximum moment2.75.28.8-2.82.5-3.0-2.82.6-2.32.42.4-2.12.42.01.90.90.5
Mean time between licks in bursts0.10.52.3-0.50.6-0.1-0.40.6-0.60.50.5-0.60.50.71.01.11.5
Mean num. licks in bursts0.10.30.50.7-0.50.70.6-0.70.6-0.6-0.60.5-0.5-0.6-0.40.30.0
Cd content in liver1.41.62.71.2-1.20.91.2-1.21.2-1.1-1.11.2-1.2-1.1-1.5-1.5-1.6
Co content in liver1.31.64.01.7-1.42.01.7-1.31.1-1.4-1.41.0-1.2-0.9-0.7-0.00.3
Cu content in liver0.10.10.30.20.0-0.1-0.00.10.20.10.10.2-0.2-0.3-0.40.5-0.6
Fe content in liver0.20.20.6-0.50.6-0.3-0.30.5-0.50.50.5-0.40.40.50.6-0.20.8
K content in liver0.40.40.7-0.80.7-0.8-0.90.7-0.60.70.7-0.50.60.40.50.30.0
Mg content in liver0.40.40.60.6-0.60.60.5-0.60.7-0.6-0.60.8-0.7-0.8-0.7-0.5-0.8
Mn content in liver3.64.05.1-2.32.2-2.2-2.12.1-2.12.22.2-2.02.12.11.90.91.1
Na content in liver0.40.50.8-0.60.7-0.5-0.60.7-0.80.70.7-0.80.70.90.80.10.8
Rb content in liver2.12.43.21.8-1.51.71.6-1.51.7-1.5-1.51.7-1.6-1.6-1.5-1.1-1.2
Se content in liver0.20.31.30.3-0.20.10.4-0.20.4-0.2-0.20.5-0.4-0.4-0.6-1.1-1.1
Sr content in liver2.92.53.2-1.61.6-1.4-1.51.6-1.81.61.6-1.81.71.81.81.11.4
Zn content in liver0.20.31.0-0.40.5-0.5-0.60.6-0.50.50.5-0.50.50.40.41.00.3
Bone: minimum diameter0.91.86.20.8-1.00.30.6-0.91.3-1.0-1.01.5-1.2-1.7-1.7-1.6-2.5
Time in familiar zone, hab. session 10.30.30.60.5-0.50.30.4-0.40.6-0.4-0.40.7-0.6-0.7-0.7-0.5-0.8
Time in novel zone, hab. session 10.20.20.70.5-0.40.80.6-0.50.3-0.6-0.60.2-0.4-0.10.1-0.10.6
Total zone transitions, hab. session 10.71.01.4-1.01.0-1.1-1.11.1-0.91.11.1-0.91.00.80.81.20.5
Total locomotion distance, hab. session 10.30.40.80.4-0.80.30.4-0.70.7-0.7-0.70.7-0.5-0.9-0.8-0.5-0.8
Locomotion velocity, hab. session 10.00.00.1-0.0-0.3-0.2-0.1-0.20.2-0.2-0.20.2-0.0-0.3-0.30.0-0.4
Time in familiar zone, hab. session 20.10.10.90.20.00.50.2-0.00.0-0.1-0.10.0-0.20.20.30.10.9
Time in novel zone, hab. session 20.10.10.3-0.40.2-0.5-0.40.2-0.20.20.2-0.20.4-0.0-0.00.4-0.5
Total zone transitions, hab. session 21.31.73.1-1.71.3-1.8-1.81.4-1.11.31.3-1.11.40.70.91.40.2
Total locomotion distance, hab. session 20.10.10.4-0.3-0.2-0.4-0.4-0.20.2-0.2-0.20.3-0.0-0.6-0.30.2-0.6
Locomotion velocity, hab. session 20.20.20.9-0.1-0.4-0.3-0.2-0.30.4-0.4-0.40.5-0.2-0.8-0.6-0.2-1.0
Novel to familiar place preference ratio0.91.12.4-1.31.0-1.5-1.21.1-1.11.11.1-1.11.21.00.70.6-0.0
Novelty place preference0.40.51.2-0.80.6-1.1-0.80.7-0.70.70.7-0.70.80.60.30.4-0.3
Time in novel zone, NPP test0.30.30.9-0.70.5-0.9-0.70.6-0.60.60.6-0.60.70.50.30.3-0.2
Total zone transitions, NPP test2.33.44.8-2.21.9-2.2-2.11.9-1.81.81.8-1.82.01.61.61.60.8
Total locomotion distance, NPP test0.10.10.2-0.50.2-0.5-0.50.2-0.10.10.1-0.10.3-0.10.00.4-0.3
Locomotion velocity, NPP test0.10.10.3-0.50.3-0.6-0.60.3-0.20.30.3-0.20.40.00.10.5-0.3
Intraocular pressure0.81.42.11.3-1.31.21.4-1.31.0-1.3-1.30.9-1.2-0.8-1.2-1.2-0.6
Delta distance traveled before/after self-admin0.20.20.70.7-0.30.80.6-0.30.3-0.4-0.40.2-0.40.0-0.10.40.8
Delta ambulatory time before/after self-admin0.10.21.00.5-0.10.60.3-0.10.1-0.1-0.1-0.1-0.20.20.20.61.0
Parametrial fat weight4.09.411.52.8-3.12.32.7-3.23.1-3.2-3.23.2-2.9-3.2-3.3-3.2-3.4
Pavlov. Cond. lever latency0.20.30.60.8-0.60.80.7-0.60.5-0.6-0.60.5-0.6-0.4-0.4-0.3-0.1
Pavlov. Cond. magazine entry latency0.20.31.0-0.80.5-1.0-0.80.4-0.40.40.4-0.40.50.10.10.5-0.6
Pavlov. Cond. change in total contacts0.20.20.9-0.50.2-0.8-0.50.3-0.20.30.3-0.20.30.1-0.20.1-0.9
Pavlov. Cond. index score0.20.30.6-0.70.5-0.8-0.60.5-0.50.40.4-0.50.50.40.30.3-0.2
Pavlov. Cond. latency score0.10.10.4-0.60.4-0.6-0.60.3-0.30.30.3-0.30.40.20.20.3-0.2
Pavlov. Cond. lever contacts0.10.10.3-0.50.4-0.5-0.50.4-0.20.30.3-0.20.30.10.10.1-0.2
Pavlov. Cond. magazine entry number0.30.40.70.7-0.60.80.7-0.60.7-0.6-0.60.7-0.6-0.6-0.4-0.50.1
Pavlov. Cond. intertrial magazine entries0.50.61.01.0-0.80.91.0-0.40.7-0.4-0.40.8-0.9-0.5-0.9-0.8-0.7
Pavlov. Cond. lever-magazine prob. diff.0.40.41.0-0.90.7-1.0-0.90.6-0.70.60.6-0.60.60.50.40.5-0.2
Pavlov. Cond. response bias0.20.30.5-0.60.6-0.7-0.60.6-0.50.50.5-0.50.50.50.30.3-0.1
Pavlov. Cond. lever latency0.60.81.41.1-1.01.21.0-1.01.0-1.0-1.00.9-1.0-0.9-0.70.2-0.1
Pavlov. Cond. magazine entry latency4.05.77.4-2.62.5-2.7-2.62.7-2.42.62.6-2.32.42.22.12.11.1
Pavlov. Cond. change in total contacts1.02.54.8-1.81.8-2.2-1.81.8-1.61.81.8-1.51.61.51.00.8-0.1
Pavlov. Cond. index score2.23.55.7-2.11.9-2.4-2.12.1-1.92.12.1-1.82.01.71.51.00.4
Pavlov. Cond. latency score1.82.95.0-2.01.8-2.2-2.02.0-1.82.02.0-1.71.81.61.30.80.3
Pavlov. Cond. lever contacts0.60.91.4-1.11.0-1.2-1.01.0-1.01.01.0-0.91.00.90.8-0.10.1
Pavlov. Cond. magazine entry number7.49.612.13.4-3.33.53.3-3.33.2-3.3-3.33.1-3.2-3.0-2.7-2.6-1.5
Pavlov. Cond. intertrial magazine entries0.71.61.91.3-1.31.21.3-1.31.2-1.4-1.41.2-1.3-1.1-1.2-1.4-1.0
Pavlov. Cond. lever-magazine prob. diff.2.84.36.6-2.32.1-2.6-2.32.3-2.12.32.3-2.12.21.91.71.30.6
Pavlov. Cond. response bias2.23.04.5-2.01.8-2.1-1.91.9-1.81.91.9-1.81.91.61.50.90.5
Time in closed arm before self-admin0.20.41.30.4-0.50.10.4-0.40.6-0.5-0.50.6-0.5-0.6-0.8-0.8-1.1
Time in closed arm after self-admin0.20.20.40.6-0.40.60.5-0.30.6-0.4-0.40.6-0.6-0.5-0.5-0.2-0.2
Time in open arm before self-admin0.40.41.30.6-0.61.10.6-0.70.5-0.5-0.50.4-0.4-0.50.10.91.1
Time in open arm after self-admin0.10.10.3-0.20.10.0-0.20.1-0.30.20.2-0.30.30.20.30.50.5
Bone: periosteal estimation0.10.32.2-0.40.1-0.6-0.30.10.10.00.00.3-0.0-0.3-0.4-1.5-1.2
Bone: periosteal perimeter0.20.30.9-0.70.4-0.9-0.70.5-0.40.40.4-0.20.40.20.0-0.8-0.8
Bone: post-yield work0.91.55.7-1.60.8-2.3-1.70.9-0.40.80.8-0.20.8-0.2-0.5-0.4-2.4
Progressive ratio test 1 active lever presses0.20.30.80.5-0.80.30.5-0.30.6-0.2-0.20.6-0.6-0.6-0.7-0.9-0.8
Progressive ratio test 1 breakpoint0.20.30.80.4-0.70.20.4-0.30.5-0.1-0.10.6-0.5-0.6-0.7-0.9-0.7
Progressive ratio test 1 inactive lever presses0.00.10.20.3-0.40.20.3-0.30.3-0.2-0.20.2-0.3-0.2-0.40.40.1
Progressive ratio test 2 active lever presses2.13.04.51.6-1.91.31.7-1.51.8-1.4-1.41.8-1.8-1.8-2.0-2.1-1.9
Progressive ratio test 2 breakpoint2.32.94.51.6-1.91.31.7-1.51.7-1.4-1.41.8-1.8-1.7-2.0-2.1-1.9
Progressive ratio test 2 inactive lever presses3.410.813.23.3-3.32.83.3-3.23.4-3.2-3.23.4-3.4-3.3-3.6-3.3-3.4
Incentive Sensitization - Responses0.00.10.8-0.2-0.1-0.3-0.10.10.20.10.10.3-0.2-0.3-0.4-0.7-0.9
Incentive Sensitization - Breakpoint0.10.21.00.0-0.4-0.10.1-0.10.4-0.1-0.10.5-0.4-0.5-0.6-0.8-1.0
Sum of active levers in priming session hrs 5-61.41.33.0-0.91.2-1.1-0.81.2-1.41.31.3-1.31.01.71.1-0.20.9
Progressive ratio0.41.33.6-1.71.1-1.9-1.70.9-0.91.01.0-0.91.20.40.60.7-0.4
Food seeking constrained by brief footshock0.10.10.4-0.20.3-0.0-0.20.3-0.20.40.4-0.30.20.40.40.50.6
Seeking ratio, punishment vs. effort0.81.74.81.9-1.32.21.8-1.11.3-1.2-1.21.2-1.4-0.8-0.8-0.50.5
Retroperitoneal fat weight9.743.446.86.8-6.86.56.6-6.86.8-6.8-6.86.8-6.7-6.8-6.5-6.2-5.2
Reaction time number correct0.10.51.1-0.60.5-0.4-0.50.6-0.70.60.6-0.80.80.70.90.21.0
Reaction time mean minus median0.84.97.4-2.62.3-2.7-2.52.3-2.32.22.2-2.22.32.11.81.91.4
Reaction time mean minus median AUC0.42.73.3-1.81.6-1.8-1.71.7-1.71.61.6-1.71.71.71.51.51.5
Reaction time num false alarms0.30.41.40.8-0.61.20.8-0.60.7-0.4-0.40.7-0.8-0.5-0.40.20.5
Reaction time num false alarms AUC0.10.21.10.10.10.50.10.10.00.20.20.0-0.20.10.20.91.0
Reaction time trials correct on left0.10.51.1-0.60.5-0.4-0.50.6-0.70.60.6-0.80.80.70.90.21.0
Reaction time trials on left0.20.61.4-0.70.6-0.5-0.60.7-0.80.80.8-0.90.90.81.10.31.2
Reaction time mean0.00.10.3-0.50.2-0.5-0.30.2-0.30.00.0-0.40.40.3-0.00.5-0.0
Reaction time mean AUC0.00.10.3-0.40.2-0.5-0.30.1-0.2-0.0-0.0-0.30.30.2-0.20.5-0.2
Median of all reaction times0.10.20.40.2-0.40.10.3-0.50.3-0.6-0.60.2-0.2-0.4-0.60.0-0.6
Reaction time omissions2.03.24.3-1.81.8-1.8-1.81.9-1.81.71.7-1.81.81.61.62.11.7
Reaction time false alarm rate0.20.30.80.7-0.50.90.6-0.50.7-0.4-0.40.7-0.8-0.5-0.50.30.2
Reaction time premature initiation rate2.53.95.8-1.92.0-1.4-1.81.8-2.01.91.9-2.01.81.92.42.02.4
Reaction time premature initiations2.16.510.2-2.32.4-1.8-2.22.3-2.62.52.5-2.62.52.63.12.53.2
Std. dev. reaction times0.51.62.4-1.41.3-1.5-1.31.2-1.31.01.0-1.41.31.20.91.30.9
Reaction time trials completed0.20.61.4-0.70.6-0.5-0.60.7-0.80.80.8-0.90.90.81.10.31.2
Reaction time trials AUC0.10.41.1-0.50.4-0.3-0.40.5-0.60.60.6-0.70.70.60.90.21.0
Run reversals in cocaine runway, females0.30.30.7-0.70.5-0.6-0.80.6-0.30.60.6-0.30.60.00.40.80.3
Run reversals in cocaine runway, males0.40.41.00.9-0.61.00.9-0.60.4-0.5-0.50.4-0.5-0.1-0.2-1.00.3
Latency to leave start box in cocaine runway0.10.21.10.2-0.1-0.10.0-0.00.4-0.2-0.20.5-0.4-0.6-0.7-0.4-1.0
Latency to leave start box in cocaine runway, F0.10.10.60.1-0.2-0.1-0.00.00.3-0.1-0.10.3-0.1-0.5-0.40.1-0.8
Latency to leave start box in cocaine runway, M0.10.10.3-0.10.4-0.3-0.30.4-0.00.20.20.1-0.10.1-0.2-0.5-0.3
Std. dev. time between licks in bursts0.10.10.80.3-0.20.60.3-0.10.1-0.2-0.20.1-0.2-0.00.40.20.9
Total sessions with >9 infusions0.10.21.2-0.3-0.1-0.4-0.20.20.20.20.20.30.0-0.5-0.4-0.8-1.1
Short access day 1 total inactive lever presses1.42.73.51.8-1.61.71.8-1.71.9-1.6-1.61.7-1.8-1.7-1.8-1.0-0.9
Short access day 10 total inactive lever presses0.10.71.21.1-0.81.10.9-0.80.9-0.8-0.80.7-0.9-0.7-0.70.90.7
Short access day 1 total infusions1.12.23.31.2-1.51.01.2-1.31.6-1.3-1.31.7-1.3-1.8-1.7-1.5-1.8
Short access day 10 total infusions0.60.94.10.3-0.8-0.10.2-0.31.0-0.2-0.21.1-0.6-1.4-1.4-1.2-2.0
Short access total infusions0.50.71.80.4-0.80.20.4-0.50.9-0.4-0.41.0-0.6-1.2-1.1-1.1-1.3
Short access day 1 locomotion1.32.12.81.4-1.51.11.3-1.31.6-1.2-1.21.7-1.5-1.6-1.7-1.4-1.6
Short access day 10 total locomotion0.41.52.90.9-1.30.60.9-1.21.3-1.1-1.11.3-1.0-1.5-1.5-1.1-1.7
Short access total locomotion1.32.04.01.2-1.40.91.1-1.31.5-1.2-1.21.5-1.3-1.7-1.7-1.6-2.0
One hour access (0.3 mA shock)7.38.710.03.0-3.22.73.0-2.93.0-3.0-3.03.0-3.0-3.0-3.0-3.0-2.5
Compulsive drug intake1.62.44.4-1.31.4-0.6-1.21.4-1.61.31.3-1.61.61.72.01.82.1
One hour access (shock baseline)3.89.912.33.1-3.32.53.1-3.03.3-3.0-3.03.3-3.3-3.3-3.5-3.3-3.1
Social response proportion0.60.81.2-1.01.1-1.0-0.91.0-1.00.80.8-0.90.91.10.80.60.4
Social responses0.30.30.8-0.50.5-0.4-0.40.5-0.60.50.5-0.60.60.70.70.60.9
Social time0.40.61.9-0.60.6-0.4-0.50.6-0.80.50.5-0.90.90.81.00.91.4
Soleus weight4.613.715.43.8-3.83.73.8-3.93.8-3.9-3.93.7-3.8-3.7-3.6-3.5-2.9
Bone: stiffness2.24.07.3-2.52.1-2.7-2.42.2-2.02.12.1-1.92.11.71.60.80.1
Tibialis anterior weight11.138.343.1-6.66.5-6.0-6.16.4-6.56.46.4-6.56.46.46.34.65.5
Time to tail flick, vehicle, before self-admin0.10.20.5-0.60.3-0.7-0.60.4-0.40.40.4-0.30.50.10.20.2-0.0
Time to tail flick, vehicle, after self-admin0.20.51.3-1.10.6-1.1-1.10.5-0.50.50.5-0.40.80.00.50.7-0.0
Time to tail flick, test, before self-admin2.22.53.91.4-1.51.31.3-1.71.8-1.7-1.71.7-1.5-2.0-1.6-1.1-1.7
Time to tail flick, test, after self-admin0.00.00.1-0.20.2-0.3-0.20.1-0.30.10.1-0.30.30.30.1-0.20.2
Delta time to tail flick, vehicle, before/after SA0.30.30.5-0.70.6-0.6-0.70.5-0.50.40.4-0.40.60.30.50.70.3
Delta time to tail flick, test, before/after SA1.82.34.1-1.31.4-1.1-1.11.4-1.81.41.4-1.81.52.01.70.91.9
Tibia length1.02.94.5-1.91.7-2.1-1.71.9-1.91.91.9-1.71.82.01.3-0.50.0
Ambulatory time before self-admin0.20.51.5-1.00.8-1.2-0.90.8-0.60.70.7-0.60.70.50.1-0.1-0.7
Ambulatory time after self-admin0.20.31.40.5-0.30.10.3-0.30.5-0.4-0.40.4-0.4-0.4-0.9-0.3-1.2
Bone: tissue strength0.00.00.0-0.20.1-0.2-0.10.10.00.00.0-0.00.1-0.0-0.00.0-0.2
Total heroin consumption5.96.97.9-2.82.7-2.7-2.72.6-2.72.62.6-2.72.72.62.62.72.2
Bone: trabecular number0.61.22.8-1.41.1-1.7-1.41.3-1.01.21.2-0.81.10.70.50.0-0.7
Bone: trabecular spacing0.40.61.31.0-0.91.10.9-0.90.8-0.8-0.80.6-0.7-0.7-0.40.40.4
Bone: trabecular thickness0.40.51.40.6-0.60.30.4-0.40.7-0.5-0.50.8-0.6-0.8-0.9-0.7-1.2
Bone: trabecular tissue density3.76.57.72.8-2.62.62.8-2.72.6-2.7-2.72.5-2.6-2.4-2.5-2.4-1.8
Water consumed over 24 hours0.81.52.3-1.01.2-0.9-1.11.2-1.31.21.2-1.31.31.31.41.51.1
Number of responses in last shaping day0.10.10.40.2-0.30.30.2-0.00.0-0.0-0.00.0-0.10.00.10.50.6