Kif13b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Kif13b	0.09	0.06	8.4e-09	0.06	0.07	0.06	0.06	1.2e-07	5.9e-08	2.2e-07	2.9e-07
2	Brain	gene expression	Kif13b	0.16	0.09	1.1e-14	0.16	0.17	0.17	0.17	3.8e-15	2.1e-15	3.0e-15	2.7e-15
3	Adipose	gene expression	Kif13b	0.08	0.05	2.6e-09	0.09	0.08	0.08	0.08	7.8e-10	5.0e-09	2.2e-09	1.9e-09
4	NAcc	gene expression	Kif13b	0.06	0.04	2.6e-05	0.01	0.03	0.02	0.01	5.5e-02	5.9e-04	7.0e-04	4.2e-02
5	Brain	mRNA stability	Kif13b	0.04	0.03	2.7e-03	0.02	0.01	0.01	0.02	3.0e-03	1.5e-02	3.2e-02	1.1e-02
6	Brain	intron excision ratio	chr15_39029832_39032483	0.14	0.09	1.0e-08	0.11	0.1	0.1	0.1	3.5e-10	6.7e-10	2.5e-09	7.7e-10
7	IL	gene expression	Kif13b	0.28	0.17	3.7e-03	0.08	0.06	0.05	0.06	6.4e-03	1.5e-02	2.7e-02	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.8	1.3	1.8	-1.2	1.2	-1.1	1.3	0.2	1.1	-1.3
Area under the delay curve	7.0	7.4	9.8	3.0	-3.0	2.5	-3.1	0.6	-2.9	3.0
BMI with tail	1.4	4.6	6.2	2.5	-2.5	2.4	-2.5	0.7	-2.0	1.9
BMI without tail	0.1	0.2	0.4	-0.3	0.3	-0.7	0.2	-0.6	-0.2	0.2
Body weight	1.1	4.6	7.2	2.5	-2.5	2.7	-2.3	2.4	-0.8	0.8
Weight adjusted by age	1.2	1.3	4.3	0.4	-0.5	0.8	-0.1	2.1	1.4	-1.4
Bone surface	0.4	0.7	1.0	-0.9	0.9	-0.8	0.9	0.2	0.8	-1.0
Bone volume	0.1	0.1	0.2	-0.4	0.4	-0.5	0.4	-0.0	0.1	-0.3
Breakpoint value in progressive ratio session	1.3	1.4	2.7	1.1	-1.1	0.5	-1.3	-0.7	-1.6	1.5
Number of licking bursts	0.6	0.8	1.1	0.9	-0.9	0.8	-1.0	-0.2	-1.0	1.1
Context. condit. distance diff. score	1.4	1.7	6.1	-0.6	0.6	-1.2	0.2	-2.5	-1.3	1.4
Locomotion velocity, session 1	0.2	0.2	0.2	0.5	-0.5	0.4	-0.5	0.0	-0.4	0.4
Locomotion distance, session 1	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0	-0.1	0.0	-0.0
Locomotion velocity, session 2	0.5	0.6	1.0	0.7	-0.7	0.5	-0.8	-0.3	-0.9	1.0
Locomotion distance, session 2	0.1	0.2	0.3	-0.4	0.4	-0.4	0.5	0.0	0.5	-0.5
Locomotion velocity, session 3	0.5	0.6	1.8	0.7	-0.7	1.0	-0.5	1.3	0.3	-0.4
Locomotion distance, session 3	0.5	0.5	0.8	0.9	-0.9	0.9	-0.8	0.5	-0.5	0.5
Stereotopy head waving bouts, day 3	1.0	1.1	2.4	-0.8	0.8	-0.4	1.0	0.9	1.5	-1.6
Stereotopy head waving duration, day 3	0.7	0.8	2.7	0.4	-0.4	0.8	-0.1	1.6	0.9	-1.1
Locomotion velocity, session 7	1.2	1.3	4.3	-0.7	0.7	-1.3	0.4	-2.1	-1.0	1.0
Locomotion distance, session 7	1.5	1.9	4.3	-1.4	1.4	-1.9	1.0	-2.1	-0.4	0.4
Stereotopy head waving bouts, day 7	0.9	1.0	1.9	1.2	-1.2	1.4	-1.0	1.3	-0.0	-0.0
Stereotopy head waving duration, day 7	1.5	1.8	4.2	1.4	-1.4	1.8	-1.0	2.0	0.4	-0.4
Locomotion velocity, session 8	0.4	0.5	1.1	0.5	-0.5	0.2	-0.6	-0.6	-1.0	1.0
Locomotion distance, session 8	0.5	0.7	2.3	-0.4	0.4	-0.8	0.1	-1.5	-0.8	0.8
Degree of sensitization distance	4.0	4.0	7.9	-2.2	2.2	-2.7	1.7	-2.8	-0.2	0.2
Degree of sensitization stereotypy	1.1	1.2	1.9	1.3	-1.3	1.4	-1.2	0.8	-0.7	0.7
Conditioned locomotion	0.3	0.3	0.8	-0.5	0.5	-0.7	0.4	-0.9	-0.3	0.2
Cocaine response after cond. corrected	1.0	1.1	2.5	0.4	-0.4	0.0	-0.7	-1.5	-1.6	1.6
Cocaine response after cond. not corrected	0.9	0.9	2.1	0.5	-0.5	0.2	-0.8	-1.1	-1.4	1.4
Cocaine response before conditioning	0.3	0.4	1.2	0.1	-0.1	0.4	0.1	1.1	0.8	-0.8
Saline control response	0.0	0.0	0.1	-0.0	0.0	0.1	0.1	0.3	0.4	-0.3
Bone: connectivity density	3.3	5.1	7.2	-2.4	2.4	-2.0	2.6	0.5	2.5	-2.7
Bone: cortical apparent density	0.2	0.3	0.5	0.5	-0.6	0.4	-0.6	-0.1	-0.7	0.6
Bone: cortical area	1.9	2.9	4.6	1.7	-1.7	1.3	-1.9	-0.3	-2.1	2.0
Bone: cortical porosity	1.5	1.6	2.6	1.5	-1.5	1.6	-1.3	1.4	-0.4	0.3
Bone: cortical porosity	1.1	1.2	1.8	1.3	-1.3	1.3	-1.1	1.2	-0.4	0.3
Bone: cortical thickness	3.1	5.0	6.8	2.4	-2.4	2.0	-2.6	0.0	-2.5	2.5
Bone: cortical thickness	5.7	6.6	12.9	2.1	-2.1	1.2	-2.6	-1.9	-3.6	3.5
Bone: cortical tissue density	0.2	0.3	0.4	0.5	-0.5	0.4	-0.6	-0.1	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.3	-0.3	0.5	-0.2	0.7	0.3	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.4	0.3	-0.2	0.4	0.3	0.7	-0.6
Condit. Reinf. active responses	0.2	0.3	0.5	0.6	-0.6	0.7	-0.5	0.7	-0.0	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.4	-0.4	0.4	-0.3	0.5	-0.0	0.0
Incentive salience index mean	1.0	1.3	2.1	1.3	-1.3	1.5	-1.2	1.2	-0.3	0.4
Condit. Reinf. lever presses	1.7	2.2	3.4	1.8	-1.8	1.8	-1.7	1.2	-0.8	0.8
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	-0.1	0.1	-0.4	-0.0	-0.9	-0.7	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.0	0.0	-0.2	-0.1	-0.6	-0.5	0.4
Condit. Reinf. active responses	0.2	0.3	0.9	-0.3	0.3	-0.7	0.2	-0.9	-0.5	0.4
Condit. Reinf. inactive responses	0.6	0.7	1.4	-1.0	1.0	-1.2	0.8	-0.9	0.1	-0.1
Condit. Reinf. lever presses	0.3	0.5	1.0	-0.3	0.3	-0.0	0.5	0.9	1.0	-1.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.4	-0.1	0.1	-0.3	-0.0	-0.6	-0.5	0.4
Conditioned reinforcement - actives	6.0	6.0	9.6	-2.9	2.9	-3.1	2.6	-2.4	1.2	-1.3
Conditioned reinforcement - inactives	2.1	2.3	3.2	-1.7	1.7	-1.3	1.8	-0.4	1.6	-1.6
Conditioned locomotion	1.4	1.6	5.3	-0.9	0.9	-1.7	0.5	-2.3	-0.9	0.8
Patch foraging indifference point 0 sec	0.2	0.4	0.8	-0.1	0.1	0.2	0.3	0.9	0.8	-0.9
Patch foraging indifference point AUC	1.0	1.1	2.6	0.5	-0.5	-0.3	-0.8	-1.3	-1.5	1.6
Delay disc. indifference point, 0s delay	0.0	0.1	0.2	0.1	-0.1	0.2	-0.2	-0.0	-0.3	0.4
Delay disc. indifference point, 16s delay	5.5	5.6	7.5	2.6	-2.6	1.9	-2.7	0.2	-2.7	2.7
Delay disc. indifference point, 2s delay	0.6	0.6	0.9	0.8	-0.8	0.8	-0.9	0.3	-0.8	0.9
Delay disc. indifference point, 24s delay	7.2	7.0	11.1	2.7	-2.7	2.0	-3.0	-0.1	-3.3	3.3
Delay disc. indifference point, 4s delay	4.1	4.3	5.9	2.4	-2.3	2.4	-2.3	1.1	-1.8	1.8
Delay disc. indifference point, 8s delay	7.2	7.5	10.1	3.1	-3.1	2.7	-3.2	0.8	-2.8	2.8
Indifference point function ln k	0.5	0.7	2.1	0.4	-0.4	1.0	-0.1	1.5	0.7	-0.8
Indifference point function log k	0.5	0.7	2.1	0.4	-0.4	1.0	-0.1	1.5	0.7	-0.8
Patch foraging total patch changes 0 sec	0.2	0.4	1.2	0.2	-0.2	0.5	-0.0	1.1	0.7	-0.6
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	0.6	-0.6	0.2	-0.6	-0.0	-0.6	0.7
Patch foraging total patch changes 18 sec	0.2	0.3	0.8	-0.2	0.2	-0.7	0.0	-0.9	-0.5	0.7
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	0.2	-0.2	0.0	-0.1	0.4	0.2	-0.1
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	0.2	-0.2	0.1	-0.2	0.1	-0.1	0.2
Patch foraging time to switch 0 sec	0.1	0.1	0.2	-0.4	0.4	-0.3	0.3	-0.3	0.1	-0.1
Patch foraging water rate 0 sec	0.6	1.0	1.6	1.3	-1.2	1.2	-1.1	1.0	-0.5	0.4
Patch foraging water rate 12 sec	0.2	0.3	0.7	0.6	-0.6	0.8	-0.5	0.6	-0.2	0.1
Patch foraging water rate 18 sec	2.1	2.8	4.5	2.1	-2.1	1.9	-1.9	1.7	-0.6	0.6
Patch foraging water rate 24 sec	0.2	0.3	0.8	0.4	-0.4	0.1	-0.5	-0.5	-0.9	0.8
Patch foraging water rate 6 sec	0.6	0.8	1.8	1.0	-0.9	1.3	-0.7	1.3	0.2	-0.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.3	0.2	-0.1	0.3	0.2	0.4	-0.4
Distance traveled before self-admin	0.3	0.3	0.6	-0.4	0.5	-0.4	0.6	0.3	0.7	-0.8
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	0.2	-0.2	0.2	-0.0	0.2	-0.2
Extensor digitorum longus weight	4.9	19.2	32.2	5.3	-5.3	5.7	-4.9	3.4	-2.1	2.2
Bone: elastic displacement	0.1	0.1	0.2	-0.4	0.4	-0.3	0.4	-0.1	0.5	-0.4
Bone: elastic work	0.3	0.3	0.8	0.6	-0.6	0.7	-0.5	0.9	0.1	-0.2
Bone: endosteal estimation	0.1	0.2	0.3	-0.4	0.4	-0.5	0.4	-0.1	0.3	-0.4
Bone: endosteal perimeter	0.5	1.0	1.4	-1.2	1.2	-1.2	1.2	-0.2	0.8	-1.0
Epididymis fat weight	0.1	0.2	0.5	0.2	-0.2	-0.2	-0.3	-0.5	-0.7	0.7
Delta time in closed arm before/after self-admin	0.5	0.5	0.8	-0.8	0.8	-0.5	0.9	-0.1	0.7	-0.7
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.1	0.1	0.0	0.0	-0.4	-0.1	0.0
Diff in mean of infusions in LGA sessions	2.4	2.7	4.3	2.0	-2.1	1.6	-1.9	2.0	-0.6	0.5
Delay discount exponential model param	7.5	7.9	10.5	-3.1	3.1	-2.7	3.2	-0.6	3.0	-3.1
Extinction: sum of active levers before priming	0.2	0.2	0.6	-0.1	0.1	-0.5	-0.0	-0.8	-0.5	0.6
Active lever presses in extinction session 6	0.2	0.2	0.6	-0.4	0.4	-0.8	0.3	-0.6	-0.2	0.0
Bone: final force	1.4	2.2	3.1	1.7	-1.7	1.4	-1.8	0.2	-1.6	1.6
Bone: final moment	1.0	1.6	2.2	1.5	-1.5	1.3	-1.5	0.5	-1.1	1.1
Food consumed during 24 hour testing period	0.2	0.2	0.5	-0.2	0.2	0.1	0.3	0.7	0.7	-0.7
Glucose	0.5	0.8	1.6	0.6	-0.6	0.2	-0.8	-1.0	-1.2	1.3
Heart weight	0.1	0.2	0.5	-0.2	0.2	-0.7	0.2	0.2	0.3	-0.6
Delay discount hyperbolic model param	7.1	7.5	10.1	-3.0	3.0	-2.7	3.2	-0.8	2.8	-2.9
Intermittent access intake day 1-15 change	0.9	0.9	1.4	-1.2	1.1	-1.0	1.1	-0.5	0.8	-0.8
Intermittent access intake escalation	0.8	0.8	1.2	-1.1	1.0	-1.0	0.9	-0.9	0.5	-0.5
Intermittent access intake escalation 2	0.5	0.5	0.8	-0.9	0.8	-0.7	0.8	-0.2	0.7	-0.6
Intermitt. access day 1 inactive lever presses	1.2	1.2	1.7	-1.2	1.2	-1.0	1.3	-0.2	1.3	-1.2
Intermitt. access day 15 inactive lever presses	1.9	2.1	4.7	-0.7	0.7	0.0	1.1	1.8	2.2	-2.0
Intermitt. access escalation Index	0.7	0.6	2.4	-0.4	0.4	-0.5	0.1	-1.5	-0.9	0.8
Intermittent access day 1 total infusions	0.4	0.4	1.6	-0.2	0.2	-0.3	-0.0	-1.3	-0.9	0.8
Intermittent access day 15 total infusions	1.2	1.4	3.9	-1.2	1.2	-1.3	0.9	-2.0	-0.2	0.2
Intermittent access terminal intake (last 3 days)	0.9	1.0	3.1	-1.0	1.0	-1.0	0.7	-1.8	-0.3	0.2
Intermittent access total infusions	1.2	1.3	5.1	-0.9	0.9	-1.0	0.5	-2.3	-0.8	0.8
Intermittent access day 1 locomotion	0.4	0.4	0.8	0.6	-0.6	0.5	-0.7	-0.4	-0.9	0.9
Intermittent access day 15 total locomotion	0.2	0.2	0.5	-0.5	0.5	-0.6	0.3	-0.7	-0.1	0.2
Intermittent access total locomotion	0.2	0.2	0.5	0.1	-0.2	0.1	-0.3	-0.7	-0.7	0.6
Intermittent access standard deviation	0.7	0.7	1.2	-1.1	1.1	-0.8	1.0	-0.7	0.6	-0.6
Left kidney weight	0.6	1.8	6.1	1.0	-1.1	1.4	-0.7	2.5	0.9	-1.0
Right kidney weight	1.0	2.9	10.9	1.2	-1.2	1.5	-0.7	3.3	1.3	-1.4
Cocaine induced anxiety	0.2	0.3	1.4	0.3	-0.3	0.2	-0.1	1.2	0.4	-0.4
Post-drug Anxiety	1.3	1.4	4.5	-0.1	0.1	0.2	0.5	2.1	1.6	-1.5
Baseline Anxiety	0.1	0.1	0.1	-0.2	0.2	0.4	0.3	-0.2	0.3	-0.3
Tail length	1.0	3.0	3.9	-1.8	1.8	-1.7	1.9	0.5	2.0	-2.0
Length with tail	0.4	1.3	4.9	0.2	-0.2	0.5	0.1	2.2	1.4	-1.4
Length without tail	2.0	4.5	8.1	2.4	-2.4	2.8	-2.0	2.7	-0.3	0.3
Times rat made contact with spout	0.0	0.1	0.2	-0.2	0.2	-0.2	0.2	-0.4	0.1	0.1
Lifetime Intake	1.4	1.6	5.1	-1.2	1.2	-1.2	0.9	-2.3	-0.5	0.4
Liver weight, left	1.3	2.1	3.3	1.7	-1.8	1.8	-1.6	1.6	-0.5	0.5
Liver weight, right	1.2	2.1	3.0	1.7	-1.7	1.7	-1.7	0.9	-1.0	1.1
Locomotor activity	1.5	2.4	6.6	1.5	-1.5	1.8	-1.1	2.6	0.7	-0.6
Locomotor testing distance	0.6	1.1	2.6	-0.3	0.3	0.2	0.6	1.4	1.6	-1.5
Locomotor testing rearing	2.9	4.5	10.6	-1.5	1.5	-0.7	2.0	1.7	3.3	-3.0
Locomotion in novel chamber	0.5	0.6	0.8	0.9	-0.9	0.9	-0.8	0.9	-0.2	0.2
Locomotion in novel chamber post-restriction	0.6	0.7	1.5	0.8	-0.8	0.2	-0.9	-0.4	-1.2	1.2
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	0.3	-0.3	-0.1	-0.5	-0.5	-0.7	0.6
Change in fecal boli incidents, locomotor task	0.4	0.3	0.8	-0.3	0.3	-0.1	0.4	0.7	0.9	-0.9
Time >=10cm from walls, locomotor time 1	1.1	1.2	2.7	-0.6	0.6	-0.3	0.8	1.2	1.6	-1.6
Bouts of movement, locomotor time 1	0.2	0.2	0.4	0.0	-0.0	0.3	-0.2	-0.7	-0.6	0.6
Total resting periods, locomotor time 1	0.6	0.6	1.5	0.1	-0.1	0.1	-0.4	-1.2	-1.2	1.2
Rest time, locomotor task time 1	0.7	0.7	1.6	0.6	-0.6	0.3	-0.8	-0.7	-1.3	1.3
Distance moved, locomotor task time 1	0.5	0.5	0.9	-0.7	0.7	-0.5	0.8	0.2	0.9	-0.9
Vertical activity count, locomotor time 1	0.5	0.5	1.2	-0.1	0.1	0.3	0.4	1.0	1.1	-1.1
Time >=10cm from walls, locomotor time 2	1.4	1.4	3.1	-0.8	0.8	-0.3	1.1	1.1	1.8	-1.7
Bouts of movement, locomotor time 2	2.5	2.7	3.7	1.7	-1.7	1.6	-1.8	-0.1	-1.9	1.9
Total resting periods, locomotor time 2	3.4	3.7	4.8	2.0	-2.0	1.9	-2.1	-0.0	-2.2	2.2
Rest time, locomotor task time 2	3.6	4.1	7.3	1.9	-1.9	1.2	-2.2	-0.7	-2.7	2.7
Distance moved, locomotor task time 2	1.1	1.2	2.2	-1.1	1.1	-0.6	1.3	0.4	1.5	-1.4
Vertical activity count, locomotor time 2	0.4	0.5	1.0	-0.4	0.5	-0.0	0.6	0.7	1.0	-1.0
Light reinforcement 1	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	-0.3	-0.1	0.0
Light reinforcement 2	0.2	0.3	0.8	-0.6	0.6	-0.6	0.5	-0.9	-0.0	0.0
Bone: marrow area	0.1	0.2	0.3	-0.5	0.5	-0.6	0.5	-0.2	0.3	-0.4
Bone: maximum diameter	0.9	1.6	3.5	1.1	-1.1	0.6	-1.3	-0.7	-1.9	1.7
Bone: maximum force	1.8	3.1	4.2	1.9	-1.9	1.6	-2.1	0.1	-2.0	1.9
Bone: maximum moment	1.3	2.2	3.1	1.7	-1.7	1.5	-1.8	0.5	-1.4	1.4
Mean time between licks in bursts	4.3	6.0	8.4	-2.8	2.8	-2.5	2.9	-0.6	2.3	-2.3
Mean num. licks in bursts	0.7	0.8	1.1	-1.0	1.0	-0.9	1.1	-0.2	0.9	-0.9
Cd content in liver	0.7	0.8	1.2	-0.9	0.9	-0.7	1.0	0.2	1.1	-1.1
Co content in liver	1.6	1.9	3.2	1.3	-1.3	0.9	-1.5	-0.7	-1.8	1.7
Cu content in liver	0.1	0.2	0.4	0.4	-0.5	0.6	-0.4	0.6	0.1	-0.1
Fe content in liver	1.2	1.4	1.9	-1.3	1.3	-1.0	1.4	0.1	1.4	-1.4
K content in liver	0.2	0.2	0.8	-0.2	0.2	-0.5	0.1	-0.9	-0.4	0.4
Mg content in liver	0.5	0.5	1.0	-0.9	0.9	-1.0	0.7	-0.9	0.1	-0.1
Mn content in liver	0.7	0.8	2.1	-0.9	0.9	-1.2	0.7	-1.4	-0.3	0.3
Na content in liver	3.6	3.8	8.2	2.1	-2.1	2.6	-1.6	2.9	0.4	-0.4
Rb content in liver	1.2	1.5	2.1	-1.4	1.4	-1.4	1.4	-0.4	1.0	-1.1
Se content in liver	0.2	0.3	0.6	-0.3	0.3	-0.1	0.5	0.6	0.8	-0.8
Sr content in liver	2.4	2.2	3.1	-1.7	1.7	-1.5	1.8	0.0	1.5	-1.5
Zn content in liver	1.2	1.3	4.4	0.7	-0.7	1.2	-0.3	2.1	1.1	-1.0
Bone: minimum diameter	0.6	1.1	1.9	1.1	-1.1	0.8	-1.2	-0.1	-1.4	1.2
Time in familiar zone, hab. session 1	0.6	0.6	1.5	0.0	0.0	-0.4	-0.2	-1.2	-1.1	1.1
Time in novel zone, hab. session 1	1.0	0.9	1.6	1.1	-1.2	1.3	-1.0	1.1	-0.2	0.2
Total zone transitions, hab. session 1	0.7	1.0	1.6	1.1	-1.0	0.8	-1.1	-0.2	-1.2	1.2
Total locomotion distance, hab. session 1	0.2	0.3	0.7	0.4	-0.4	0.2	-0.5	-0.4	-0.8	0.8
Locomotion velocity, hab. session 1	0.1	0.1	0.1	0.3	-0.3	0.2	-0.3	-0.0	-0.3	0.4
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.4	0.4	-0.4	0.3	-0.5	-0.1	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	-0.3	0.2	-0.3	-0.0	-0.2	0.3
Total zone transitions, hab. session 2	0.2	0.3	0.5	0.6	-0.6	0.7	-0.5	0.6	-0.1	0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.6	-0.5	0.4	-0.6	-0.1	-0.7	0.7
Locomotion velocity, hab. session 2	0.4	0.6	0.8	0.9	-0.8	0.7	-0.9	0.2	-0.8	0.8
Novel to familiar place preference ratio	0.3	0.3	1.1	-0.3	0.3	-0.5	0.1	-1.1	-0.5	0.5
Novelty place preference	0.2	0.2	0.8	-0.4	0.4	-0.6	0.2	-0.9	-0.3	0.3
Time in novel zone, NPP test	0.1	0.1	0.5	-0.3	0.3	-0.4	0.2	-0.7	-0.2	0.2
Total zone transitions, NPP test	0.0	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.2	-0.1	0.2
Total locomotion distance, NPP test	1.0	1.3	1.9	-1.4	1.4	-1.4	1.3	-0.8	0.8	-0.8
Locomotion velocity, NPP test	1.0	1.4	2.0	-1.4	1.4	-1.4	1.3	-0.9	0.8	-0.7
Intraocular pressure	2.5	3.5	4.8	-2.2	2.2	-2.2	2.1	-0.9	1.6	-1.6
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.5	-0.5	0.5	-0.5	0.1	-0.5	0.7
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	0.4	-0.4	0.3	-0.5	-0.2	-0.8	0.8
Parametrial fat weight	1.7	3.4	7.5	-1.8	1.8	-2.6	1.4	-2.7	-0.6	0.7
Pavlov. Cond. lever latency	0.6	0.8	1.1	-1.1	1.1	-1.0	1.0	-0.5	0.7	-0.7
Pavlov. Cond. magazine entry latency	0.4	0.5	1.1	0.7	-0.7	0.9	-0.5	1.1	0.2	-0.1
Pavlov. Cond. change in total contacts	2.3	2.4	3.6	1.9	-1.9	1.8	-1.8	1.0	-1.1	1.0
Pavlov. Cond. index score	1.7	2.1	3.6	1.7	-1.7	1.9	-1.5	1.6	-0.4	0.5
Pavlov. Cond. latency score	1.2	1.5	2.5	1.5	-1.5	1.6	-1.3	1.3	-0.4	0.4
Pavlov. Cond. lever contacts	0.8	1.0	1.6	1.2	-1.2	1.3	-1.0	1.2	-0.3	0.2
Pavlov. Cond. magazine entry number	1.0	1.3	2.2	-1.3	1.3	-1.5	1.1	-1.4	0.1	-0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.1	0.1	0.0	0.2	0.6	0.5	-0.6
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.7	4.5	1.9	-2.0	2.1	-1.7	1.7	-0.5	0.6
Pavlov. Cond. response bias	1.6	1.9	3.4	1.6	-1.6	1.8	-1.4	1.6	-0.3	0.4
Pavlov. Cond. lever latency	0.9	1.2	4.2	-0.6	0.6	-1.1	0.2	-2.0	-1.1	1.1
Pavlov. Cond. magazine entry latency	1.4	1.6	2.6	1.5	-1.5	1.6	-1.3	1.3	-0.3	0.4
Pavlov. Cond. change in total contacts	1.9	2.6	6.6	1.6	-1.6	2.1	-1.2	2.6	0.5	-0.5
Pavlov. Cond. index score	1.5	1.9	4.6	1.4	-1.4	1.8	-1.1	2.2	0.4	-0.4
Pavlov. Cond. latency score	1.4	1.8	4.9	1.2	-1.2	1.7	-0.9	2.2	0.6	-0.6
Pavlov. Cond. lever contacts	0.8	1.1	3.9	0.4	-0.4	0.9	-0.1	2.0	1.2	-1.2
Pavlov. Cond. magazine entry number	0.7	0.9	1.3	-1.2	1.2	-1.1	1.1	-0.6	0.6	-0.7
Pavlov. Cond. intertrial magazine entries	6.8	8.9	13.2	-3.6	3.6	-3.6	3.4	-2.3	1.7	-1.7
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	4.2	1.5	-1.5	1.9	-1.2	2.0	0.3	-0.2
Pavlov. Cond. response bias	1.0	1.4	3.2	1.2	-1.2	1.5	-0.9	1.8	0.3	-0.3
Time in closed arm before self-admin	1.8	2.0	4.2	1.6	-1.6	2.0	-1.4	1.7	-0.2	0.1
Time in closed arm after self-admin	0.5	0.5	1.1	0.8	-0.8	1.1	-0.6	1.0	0.1	-0.0
Time in open arm before self-admin	1.0	1.0	2.3	-1.1	1.2	-1.5	1.1	-0.7	0.6	-0.7
Time in open arm after self-admin	1.0	1.1	1.3	-1.2	1.1	-1.1	1.1	-0.3	1.0	-1.1
Bone: periosteal estimation	0.2	0.4	1.0	0.5	-0.5	0.2	-0.7	-0.3	-1.0	0.8
Bone: periosteal perimeter	0.1	0.1	0.4	0.2	-0.2	-0.0	-0.3	-0.3	-0.7	0.5
Bone: post-yield work	3.7	5.0	12.0	1.2	-1.2	0.2	-1.8	-2.5	-3.5	3.3
Progressive ratio test 1 active lever presses	1.1	1.1	3.0	0.2	-0.1	-0.1	-0.5	-1.7	-1.6	1.5
Progressive ratio test 1 breakpoint	1.3	1.4	3.3	0.3	-0.2	-0.1	-0.6	-1.8	-1.8	1.7
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.4	-1.2	1.2	-1.0	1.1	-0.9	0.7	-0.9
Progressive ratio test 2 active lever presses	2.1	2.3	4.2	-1.8	1.7	-1.7	1.5	-2.0	0.3	-0.4
Progressive ratio test 2 breakpoint	1.6	1.8	2.7	-1.7	1.6	-1.5	1.4	-1.7	0.5	-0.6
Progressive ratio test 2 inactive lever presses	1.8	2.1	3.0	-1.7	1.7	-1.5	1.7	-0.8	1.1	-1.2
Incentive Sensitization - Responses	3.9	4.0	5.3	-2.3	2.2	-1.8	2.3	-0.7	2.0	-2.1
Incentive Sensitization - Breakpoint	4.3	4.4	5.8	-2.4	2.3	-1.9	2.4	-0.6	2.2	-2.3
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.7	-0.5	0.5	-0.8	0.4	-0.8	-0.3	0.4
Progressive ratio	0.6	0.6	2.2	0.5	-0.6	0.6	-0.3	1.5	0.8	-0.8
Food seeking constrained by brief footshock	0.2	0.2	0.5	0.1	-0.1	-0.0	-0.2	-0.7	-0.7	0.7
Seeking ratio, punishment vs. effort	0.4	0.5	1.5	-0.0	0.1	-0.1	-0.1	-1.2	-1.1	1.1
Retroperitoneal fat weight	0.5	1.5	4.6	-0.8	0.7	-1.5	0.3	-2.1	-1.1	1.1
Reaction time number correct	0.6	0.8	1.2	-1.0	1.1	-0.9	1.1	-0.1	0.9	-0.9
Reaction time mean minus median	0.3	0.5	1.9	0.6	-0.6	0.3	-0.4	1.4	0.5	-0.4
Reaction time mean minus median AUC	0.3	0.5	1.7	0.1	-0.1	0.0	0.1	1.3	0.9	-0.8
Reaction time num false alarms	0.4	0.6	2.3	0.4	-0.4	0.6	-0.2	1.5	0.6	-0.8
Reaction time num false alarms AUC	0.3	0.4	1.8	0.5	-0.5	0.5	-0.3	1.3	0.4	-0.6
Reaction time trials correct on left	0.6	0.8	1.2	-1.0	1.1	-0.9	1.1	-0.1	0.9	-0.9
Reaction time trials on left	0.7	1.1	1.5	-1.2	1.2	-1.0	1.2	-0.2	1.0	-1.0
Reaction time mean	0.6	0.8	1.8	-0.5	0.5	-0.6	0.7	0.9	1.3	-1.3
Reaction time mean AUC	0.8	1.1	2.4	-0.5	0.4	-0.3	0.7	1.4	1.6	-1.5
Median of all reaction times	0.8	1.1	2.1	-0.9	0.9	-0.8	1.0	0.6	1.5	-1.4
Reaction time omissions	3.5	4.8	6.2	-2.4	2.4	-2.5	2.4	-0.3	2.3	-2.3
Reaction time false alarm rate	0.6	0.8	1.3	1.0	-1.1	1.0	-0.9	1.1	-0.3	0.1
Reaction time premature initiation rate	0.6	0.8	1.2	1.0	-1.0	0.6	-1.1	-0.0	-1.1	1.1
Reaction time premature initiations	0.1	0.1	0.3	0.3	-0.3	0.0	-0.4	-0.2	-0.5	0.6
Std. dev. reaction times	0.2	0.2	0.5	-0.1	0.1	-0.5	0.2	0.7	0.6	-0.6
Reaction time trials completed	0.7	1.1	1.5	-1.2	1.2	-1.0	1.2	-0.2	1.0	-1.0
Reaction time trials AUC	0.8	1.2	1.7	-1.3	1.3	-1.1	1.3	-0.2	1.0	-1.1
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.1	0.2	-0.4	0.3	0.1	0.3	-0.3
Run reversals in cocaine runway, males	3.3	3.2	4.3	2.1	-2.1	1.9	-2.0	0.8	-1.6	1.6
Latency to leave start box in cocaine runway	1.2	1.3	1.9	-1.4	1.3	-1.1	1.3	-0.9	0.9	-0.9
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.5	0.5	-0.3	0.5	-0.3	0.5	-0.5
Latency to leave start box in cocaine runway, M	2.8	2.7	3.6	-1.8	1.8	-1.5	1.9	-0.1	1.9	-1.9
Std. dev. time between licks in bursts	1.9	2.3	3.1	-1.7	1.7	-1.5	1.8	-0.1	1.5	-1.6
Total sessions with >9 infusions	1.6	1.8	2.6	-1.6	1.6	-1.2	1.5	-1.0	1.1	-1.1
Short access day 1 total inactive lever presses	0.3	0.3	1.0	-0.6	0.6	-0.6	0.4	-1.0	-0.3	0.3
Short access day 10 total inactive lever presses	0.4	0.5	0.9	-0.8	0.8	-1.0	0.7	-0.6	0.4	-0.2
Short access day 1 total infusions	2.4	2.6	4.1	-2.0	2.0	-1.7	1.7	-1.9	0.5	-0.6
Short access day 10 total infusions	0.9	1.0	2.4	0.5	-0.5	0.3	-0.8	-1.2	-1.5	1.5
Short access total infusions	0.5	0.5	1.7	-0.8	0.8	-0.7	0.6	-1.3	-0.2	0.1
Short access day 1 locomotion	0.7	0.8	1.4	-0.8	0.8	-0.9	0.9	0.3	1.2	-1.2
Short access day 10 total locomotion	0.3	0.3	0.8	0.5	-0.5	0.8	-0.4	0.9	0.3	-0.3
Short access total locomotion	0.2	0.2	0.6	-0.0	-0.0	0.1	0.1	0.6	0.7	-0.8
One hour access (0.3 mA shock)	0.8	1.0	3.5	-0.5	0.5	-0.8	0.1	-1.9	-1.0	1.1
Compulsive drug intake	0.4	0.4	0.8	0.5	-0.5	0.3	-0.6	-0.2	-0.9	0.8
One hour access (shock baseline)	1.0	1.2	3.4	-1.1	1.1	-1.3	0.8	-1.8	-0.2	0.2
Social response proportion	2.2	2.4	5.1	-1.8	1.8	-2.3	1.6	-1.5	0.6	-0.6
Social responses	2.5	3.2	6.2	-2.1	2.1	-2.5	1.9	-1.7	0.8	-0.7
Social time	1.9	2.6	5.9	-1.1	1.1	-0.9	1.4	1.2	2.4	-2.3
Soleus weight	0.5	1.4	1.9	1.3	-1.3	1.1	-1.4	0.0	-1.2	1.3
Bone: stiffness	0.9	1.4	2.0	1.4	-1.4	1.2	-1.4	0.5	-1.2	1.1
Tibialis anterior weight	4.8	16.3	28.5	4.9	-4.9	5.3	-4.4	3.7	-1.4	1.4
Time to tail flick, vehicle, before self-admin	1.8	1.8	2.8	1.7	-1.6	1.6	-1.4	1.4	-0.6	0.6
Time to tail flick, vehicle, after self-admin	1.6	1.7	2.5	1.6	-1.6	1.1	-1.5	1.0	-1.1	1.1
Time to tail flick, test, before self-admin	0.2	0.2	0.6	-0.0	-0.0	-0.1	0.1	0.8	0.7	-0.7
Time to tail flick, test, after self-admin	4.0	4.1	5.7	-2.4	2.4	-2.2	2.3	-1.5	1.5	-1.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.7	0.7	-0.8	0.5	-0.7	0.1	-0.1
Delta time to tail flick, test, before/after SA	2.9	2.6	4.0	-2.0	2.0	-1.5	1.9	-1.6	0.9	-1.0
Tibia length	1.1	3.1	10.9	0.5	-0.4	1.4	0.1	3.3	2.2	-2.0
Ambulatory time before self-admin	0.0	0.0	0.1	0.0	0.0	-0.1	0.0	-0.2	-0.1	-0.0
Ambulatory time after self-admin	0.2	0.3	0.4	0.6	-0.6	0.4	-0.6	0.2	-0.6	0.5
Bone: tissue strength	0.8	0.8	1.1	-0.9	0.9	-0.7	1.0	0.5	1.0	-1.0
Total heroin consumption	0.3	0.4	0.6	0.8	-0.8	0.6	-0.8	0.4	-0.6	0.3
Bone: trabecular number	1.2	1.9	2.5	-1.5	1.5	-1.4	1.6	-0.0	1.3	-1.5
Bone: trabecular spacing	2.5	3.3	4.7	2.1	-2.1	1.8	-2.2	0.2	-1.7	1.8
Bone: trabecular thickness	0.4	0.4	0.6	0.8	-0.8	0.8	-0.8	0.4	-0.6	0.5
Bone: trabecular tissue density	1.9	2.7	4.2	2.0	-2.0	2.0	-1.9	1.2	-1.0	0.9
Water consumed over 24 hours	0.6	0.7	1.3	0.9	-0.9	1.1	-0.7	1.1	0.1	-0.0
Number of responses in last shaping day	0.0	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.1	0.0	0.0