Kif13b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	mRNA stability	Kif13b	0.16	0.16	9.8e-03	0.09	0.01	0.07	-0.01	1.8e-03	1.3e-01	6.6e-03	6.5e-01
2	Liver	gene expression	Kif13b	0.08	0.06	3.0e-08	0.06	0.06	0.05	0.05	5.0e-07	2.4e-07	3.0e-06	1.1e-06
3	Brain	gene expression	Kif13b	0.17	0.1	2.3e-14	0.16	0.17	0.16	0.16	1.9e-14	1.8e-15	2.0e-14	4.0e-15
4	NAcc	gene expression	Kif13b	0.05	0.03	1.2e-06	0.03	0.03	0.02	0	1.5e-05	4.6e-05	1.1e-04	4.5e-02
5	Adipose	gene expression	Kif13b	0.08	0.06	2.5e-09	0.09	0.08	0.07	0.08	7.7e-10	5.1e-09	6.3e-08	5.0e-09
6	IL	gene expression	Kif13b	0.28	0.17	5.1e-03	0.09	0.04	0.04	0.07	3.8e-03	3.6e-02	3.4e-02	1.1e-02
7	Brain	intron excision ratio	chr15_43205532_43208183	0.14	0.09	1.9e-08	0.11	0.1	0.09	0.09	2.5e-10	1.7e-09	4.6e-09	5.3e-09
8	Brain	mRNA stability	Kif13b	0.05	0.04	7.4e-04	0.02	0.03	0.06	0.03	5.8e-03	5.0e-04	1.1e-06	1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.9	1.6	2.1	-1.2	-1.4	1.4	-1.3	-1.3	-1.3	1.2	-0.5
Area under the delay curve	4.8	7.3	9.9	2.7	3.1	-3.1	2.6	2.7	3.1	-2.7	-0.8
BMI with tail	0.4	1.2	2.0	1.4	1.3	-1.3	1.3	1.4	0.7	-0.7	-0.1
BMI without tail	0.0	0.1	0.2	-0.2	-0.3	0.3	-0.1	-0.3	-0.4	0.4	0.2
Body weight	0.5	2.4	5.1	2.3	1.6	-1.7	2.0	2.1	-0.0	0.1	0.4
Weight adjusted by age	0.7	2.0	8.1	1.3	0.6	-0.6	1.3	0.9	-1.3	1.3	2.8
Bone surface	0.6	1.2	1.4	-1.1	-1.2	1.2	-1.1	-1.1	-1.1	1.0	-0.8
Bone volume	0.3	0.5	0.7	-0.8	-0.7	0.7	-0.8	-0.8	-0.5	0.4	-0.8
Breakpoint value in progressive ratio session	0.9	1.7	2.8	1.1	1.4	-1.4	1.0	1.0	1.3	-1.4	-1.7
Number of licking bursts	0.2	0.7	1.0	0.8	0.9	-0.9	0.7	0.8	1.0	-1.0	-0.1
Context. condit. distance diff. score	0.9	1.1	2.2	-1.4	-0.5	0.5	-1.1	-1.1	1.5	-1.3	0.5
Locomotion velocity, session 1	0.2	0.3	0.8	0.4	0.4	-0.4	0.4	0.5	0.5	-0.4	-0.9
Locomotion distance, session 1	0.0	0.0	0.1	0.1	0.0	-0.0	-0.0	0.1	-0.0	0.0	0.3
Locomotion velocity, session 2	0.4	0.4	0.9	0.5	0.7	-0.7	0.4	0.4	0.9	-0.9	-0.6
Locomotion distance, session 2	0.2	0.2	0.4	-0.2	-0.5	0.5	-0.4	-0.5	-0.7	0.6	0.6
Locomotion velocity, session 3	0.5	0.5	1.2	0.9	0.7	-0.7	1.1	1.0	-0.3	0.3	0.2
Locomotion distance, session 3	0.6	0.7	0.8	0.8	0.9	-0.9	0.9	0.9	0.7	-0.6	0.9
Stereotopy head waving bouts, day 3	0.8	1.0	2.7	-0.3	-0.8	0.8	-0.4	-0.5	-1.7	1.6	-0.7
Stereotopy head waving duration, day 3	0.3	0.4	1.0	0.7	0.2	-0.2	0.6	0.4	-1.0	0.9	-0.0
Locomotion velocity, session 7	1.0	1.1	1.6	-1.2	-0.6	0.6	-1.1	-1.3	1.2	-1.2	-0.7
Locomotion distance, session 7	1.4	1.8	3.8	-1.8	-1.3	1.3	-1.8	-2.0	0.6	-0.6	0.2
Stereotopy head waving bouts, day 7	0.8	0.9	1.8	1.2	0.9	-0.9	1.3	1.3	-0.3	0.4	0.6
Stereotopy head waving duration, day 7	1.3	1.7	3.3	1.7	1.2	-1.2	1.7	1.8	-0.4	0.5	0.8
Locomotion velocity, session 8	0.4	0.4	1.2	0.2	0.5	-0.5	0.3	0.2	1.0	-1.1	-0.7
Locomotion distance, session 8	0.3	0.4	0.6	-0.8	-0.3	0.3	-0.7	-0.7	0.8	-0.7	0.2
Degree of sensitization distance	3.7	4.0	7.8	-2.7	-2.1	2.1	-2.7	-2.8	0.3	-0.4	-1.2
Degree of sensitization stereotypy	1.2	1.4	2.2	1.3	1.3	-1.3	1.4	1.5	0.8	-0.6	0.9
Conditioned locomotion	0.4	0.4	0.9	-0.8	-0.7	0.7	-0.9	-0.9	0.3	-0.3	-0.1
Cocaine response after cond. corrected	0.5	0.7	2.3	-0.1	0.3	-0.3	-0.1	-0.1	1.5	-1.5	-0.9
Cocaine response after cond. not corrected	0.5	0.7	1.8	0.1	0.4	-0.4	0.1	0.0	1.4	-1.3	-1.2
Cocaine response before conditioning	0.2	0.2	0.6	0.6	0.2	-0.2	0.5	0.4	-0.7	0.7	-0.2
Saline control response	0.1	0.1	0.5	0.3	-0.1	0.1	0.1	0.3	-0.7	0.7	0.1
Bone: connectivity density	2.9	4.7	6.9	-2.0	-2.5	2.5	-2.0	-2.0	-2.6	2.5	0.0
Bone: cortical apparent density	0.3	0.5	0.7	0.6	0.8	-0.8	0.8	0.6	0.6	-0.7	-0.4
Bone: cortical area	1.2	1.9	2.8	1.2	1.6	-1.6	1.1	1.2	1.7	-1.7	0.7
Bone: cortical porosity	1.6	1.7	2.3	1.5	1.5	-1.5	1.5	1.4	0.7	-0.8	1.2
Bone: cortical porosity	1.5	1.6	3.6	1.4	1.3	-1.3	1.4	1.3	0.4	-0.5	1.9
Bone: cortical thickness	2.3	3.8	5.2	1.8	2.3	-2.3	1.8	1.8	2.2	-2.2	0.9
Bone: cortical thickness	4.2	5.1	12.4	1.3	2.3	-2.3	1.3	1.3	3.5	-3.5	-0.9
Bone: cortical tissue density	0.2	0.4	0.5	0.5	0.7	-0.7	0.7	0.5	0.6	-0.6	-0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.6	0.4	-0.4	0.5	0.7	-0.1	0.2	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.1	-0.3	0.3	-0.2	0.0	-0.5	0.6	0.3
Condit. Reinf. active responses	0.3	0.3	0.7	0.7	0.7	-0.7	0.7	0.9	0.2	-0.1	-0.0
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.5	0.5	-0.5	0.6	0.5	0.1	-0.1	-0.2
Incentive salience index mean	1.1	1.4	2.6	1.5	1.4	-1.4	1.5	1.6	0.4	-0.4	0.1
Condit. Reinf. lever presses	1.6	2.4	3.6	1.8	1.9	-1.9	1.9	1.9	0.8	-0.9	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	-0.4	-0.3	0.3	-0.5	-0.6	0.4	-0.4	-0.9
Condit. Reinf. active-inactive response ratio	0.1	0.2	1.5	-0.3	-0.2	0.2	-0.3	-0.3	0.1	-0.2	-1.2
Condit. Reinf. active responses	0.3	0.4	1.2	-0.5	-0.5	0.5	-0.7	-0.8	0.2	-0.3	-1.1
Condit. Reinf. inactive responses	0.5	0.7	1.5	-0.9	-1.0	0.9	-1.2	-1.2	-0.0	0.1	-0.4
Condit. Reinf. lever presses	0.3	0.4	1.3	-0.1	-0.5	0.5	-0.2	-0.2	-1.1	1.1	0.6
Condit. Reinf. lever reinforcers received	0.1	0.2	0.5	-0.2	-0.2	0.2	-0.4	-0.5	0.3	-0.3	-0.7
Conditioned reinforcement - actives	1.1	4.3	6.9	-2.6	-2.5	2.5	-2.5	-2.4	-1.2	1.3	0.2
Conditioned reinforcement - inactives	0.8	2.2	3.2	-1.6	-1.7	1.7	-1.3	-1.1	-1.7	1.8	-0.0
Conditioned locomotion	0.7	1.0	1.5	-0.9	-0.4	0.4	-1.0	-1.2	1.2	-1.1	-1.2
Patch foraging indifference point 0 sec	0.3	0.8	3.5	0.4	-0.2	0.2	0.1	0.3	-1.0	1.0	1.9
Patch foraging indifference point AUC	0.2	0.6	1.9	-0.5	0.3	-0.2	-0.2	-0.5	1.3	-1.4	-0.7
Delay disc. indifference point, 0s delay	0.1	0.1	0.8	0.4	0.1	-0.2	0.0	0.3	0.3	-0.2	-0.9
Delay disc. indifference point, 16s delay	3.3	4.7	7.8	1.7	2.5	-2.5	1.9	1.8	2.8	-2.6	-0.6
Delay disc. indifference point, 2s delay	0.6	0.6	1.2	1.1	0.9	-0.9	0.7	0.9	0.8	-0.6	-0.1
Delay disc. indifference point, 24s delay	3.9	6.2	11.5	1.8	2.7	-2.7	1.9	1.9	3.4	-3.3	-1.4
Delay disc. indifference point, 4s delay	4.1	4.3	6.2	2.3	2.5	-2.4	2.2	2.5	1.8	-1.6	-0.5
Delay disc. indifference point, 8s delay	3.9	6.6	9.0	2.7	3.0	-3.0	2.5	2.7	2.8	-2.4	-0.4
Indifference point function ln k	0.3	0.8	2.6	0.9	0.4	-0.4	0.8	1.0	-0.6	0.6	1.6
Indifference point function log k	0.3	0.8	2.6	0.9	0.4	-0.4	0.8	1.0	-0.6	0.6	1.6
Patch foraging total patch changes 0 sec	0.2	0.7	3.0	0.8	0.2	-0.2	0.5	0.7	-0.8	0.8	1.7
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	0.6	0.6	-0.6	0.5	0.4	0.6	-0.6	-0.3
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	-0.4	-0.2	0.2	-0.4	-0.6	0.6	-0.6	-0.6
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	0.3	0.2	-0.2	0.2	0.1	-0.0	0.0	0.1
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.3	0.2	-0.2	0.2	0.1	0.1	-0.1	0.1
Patch foraging time to switch 0 sec	0.0	0.1	0.4	-0.2	-0.3	0.3	-0.4	-0.2	0.1	-0.1	-0.6
Patch foraging water rate 0 sec	0.2	0.8	1.5	1.0	1.1	-1.1	1.2	1.1	0.2	-0.2	0.7
Patch foraging water rate 12 sec	0.1	0.4	1.6	0.4	0.6	-0.6	0.7	0.8	0.0	-0.1	1.3
Patch foraging water rate 18 sec	1.2	2.6	5.3	2.3	1.9	-1.9	2.1	1.7	0.4	-0.4	0.1
Patch foraging water rate 24 sec	0.1	0.2	0.4	0.0	0.4	-0.4	0.3	0.1	0.7	-0.7	0.0
Patch foraging water rate 6 sec	0.9	1.3	5.2	0.9	0.9	-0.9	1.2	1.1	-0.2	0.2	2.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	4.1	-0.0	-0.3	0.3	-0.2	-0.3	-0.4	0.4	2.0
Distance traveled before self-admin	0.2	0.5	1.4	-0.3	-0.5	0.5	-0.1	-0.2	-1.2	1.2	0.5
Distance traveled after self-admin	0.2	0.3	0.6	0.6	0.6	-0.6	0.6	0.8	0.3	-0.2	-0.3
Extensor digitorum longus weight	5.0	20.1	33.0	5.7	5.3	-5.3	5.6	5.7	2.0	-2.1	0.4
Bone: elastic displacement	0.5	0.7	4.0	-0.4	-0.5	0.5	-0.4	-0.5	-0.4	0.4	2.0
Bone: elastic work	0.4	0.6	2.8	0.6	0.5	-0.5	0.6	0.6	-0.2	0.2	1.7
Bone: endosteal estimation	0.2	0.4	0.5	-0.6	-0.7	0.7	-0.6	-0.6	-0.7	0.6	-0.3
Bone: endosteal perimeter	0.6	1.4	1.9	-1.2	-1.4	1.4	-1.3	-1.2	-1.3	1.2	0.1
Epididymis fat weight	0.1	0.7	1.6	0.4	0.8	-0.8	0.4	0.4	1.3	-1.2	-0.7
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	-0.9	-0.6	0.6	-0.4	-0.4	-0.3	0.4	-0.2
Delta time in open arm before/after self-admin	0.2	0.3	0.6	0.8	0.4	-0.4	0.3	0.6	0.1	-0.1	0.8
Diff in mean of infusions in LGA sessions	1.9	3.4	7.8	2.8	2.2	-2.2	2.3	1.9	0.5	-0.5	-0.3
Delay discount exponential model param	6.0	8.2	11.1	-3.0	-3.3	3.3	-2.7	-2.9	-3.2	2.8	0.7
Extinction: sum of active levers before priming	0.1	0.2	0.3	0.4	0.5	-0.5	0.6	0.4	0.3	-0.3	0.5
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.7	-0.1	0.2	-0.2	-0.4	0.4	-0.6	-0.6
Bone: final force	1.0	1.6	2.4	1.2	1.5	-1.5	1.2	1.3	1.3	-1.3	0.4
Bone: final moment	0.7	1.1	1.7	1.1	1.3	-1.3	1.1	1.2	0.8	-0.8	0.6
Food consumed during 24 hour testing period	0.1	0.2	0.7	0.1	-0.3	0.3	-0.0	0.1	-0.8	0.8	0.2
Glucose	0.6	0.9	2.2	0.6	0.9	-0.9	0.6	0.6	1.4	-1.5	-0.4
Heart weight	0.2	0.3	0.8	-0.4	-0.6	0.6	-0.4	-0.9	-0.6	0.4	0.3
Delay discount hyperbolic model param	5.4	6.9	9.4	-2.8	-3.1	3.1	-2.5	-2.7	-2.9	2.5	0.7
Intermittent access intake day 1-15 change	0.2	1.2	2.0	-1.4	-1.4	1.4	-1.3	-1.1	-0.6	0.6	-0.3
Intermittent access intake escalation	0.1	0.6	1.1	-1.0	-1.1	1.0	-0.9	-0.6	-0.5	0.5	-0.2
Intermittent access intake escalation 2	0.2	0.3	0.5	-0.5	-0.7	0.7	-0.6	-0.4	-0.3	0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.1	1.1	1.6	-1.3	-1.2	1.2	-0.9	-0.7	-1.1	1.2	0.6
Intermitt. access day 15 inactive lever presses	0.2	1.1	3.9	-0.5	-0.7	0.7	-0.1	0.2	-1.9	2.0	0.5
Intermitt. access escalation Index	0.0	0.1	0.3	-0.3	-0.3	0.3	-0.5	-0.3	0.1	-0.3	0.3
Intermittent access day 1 total infusions	0.1	0.3	0.5	-0.7	-0.5	0.5	-0.7	-0.5	0.3	-0.4	-0.5
Intermittent access day 15 total infusions	0.6	1.4	2.6	-1.6	-1.4	1.4	-1.5	-1.1	-0.2	0.2	-0.6
Intermittent access terminal intake (last 3 days)	0.8	1.4	2.7	-1.6	-1.4	1.4	-1.6	-1.1	-0.2	0.2	-0.7
Intermittent access total infusions	1.4	1.7	3.5	-1.9	-1.4	1.4	-1.7	-1.2	0.2	-0.2	-1.2
Intermittent access day 1 locomotion	0.2	0.3	0.4	0.6	0.6	-0.6	0.5	0.6	0.5	-0.7	0.2
Intermittent access day 15 total locomotion	0.1	0.3	0.6	-0.5	-0.6	0.6	-0.7	-0.6	0.1	-0.0	-0.7
Intermittent access total locomotion	0.0	0.1	0.2	-0.1	-0.3	0.3	-0.4	-0.1	0.1	-0.2	0.0
Intermittent access standard deviation	0.1	0.7	1.5	-1.1	-0.9	0.9	-1.1	-0.7	-0.0	0.0	-1.2
Left kidney weight	0.2	1.4	2.4	1.6	0.8	-0.8	1.5	1.5	-1.1	1.1	1.0
Right kidney weight	0.4	3.0	3.9	1.9	0.9	-1.0	1.9	2.0	-1.9	1.8	2.0
Cocaine induced anxiety	0.3	0.9	1.5	1.2	1.1	-1.1	1.2	1.2	0.4	-0.4	0.4
Post-drug Anxiety	0.8	0.9	3.0	0.9	0.4	-0.4	0.8	0.8	-0.9	0.9	1.7
Baseline Anxiety	0.1	0.2	0.5	-0.1	-0.3	0.3	-0.2	-0.0	-0.5	0.6	0.7
Tail length	0.3	1.8	4.4	-0.7	-1.2	1.2	-0.5	-0.7	-2.1	2.1	1.1
Length with tail	0.2	0.8	2.0	0.8	0.1	-0.1	0.8	0.8	-1.4	1.4	0.9
Length without tail	0.7	3.6	6.6	2.6	2.2	-2.2	2.4	2.6	0.5	-0.5	0.1
Times rat made contact with spout	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.3	-0.2	0.1	-0.1	-0.3
Lifetime Intake	1.4	1.7	3.5	-1.9	-1.4	1.5	-1.8	-1.2	0.0	-0.1	-1.1
Liver weight, left	0.6	1.0	2.1	1.4	0.8	-0.8	1.3	1.3	-0.8	0.8	-0.1
Liver weight, right	1.3	2.2	3.2	1.7	1.8	-1.8	1.8	1.8	1.0	-1.0	0.8
Locomotor activity	1.6	2.5	4.5	2.0	1.5	-1.5	2.1	2.0	-0.6	0.6	1.4
Locomotor testing distance	0.4	0.9	2.4	-0.1	-0.4	0.4	0.2	0.3	-1.5	1.5	1.5
Locomotor testing rearing	1.0	3.8	9.1	-0.6	-1.5	1.5	-0.7	-0.6	-3.0	3.0	2.6
Locomotion in novel chamber	0.2	0.3	0.6	0.7	0.5	-0.5	0.7	0.7	-0.1	0.1	0.6
Locomotion in novel chamber post-restriction	0.3	0.9	2.3	0.6	1.0	-1.0	0.6	0.3	1.5	-1.5	0.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.5	0.7	0.2	-0.3	-0.0	-0.0	0.6	-0.6	-0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.8	-0.3	-0.3	0.3	0.0	-0.1	-0.8	0.9	-0.2
Time >=10cm from walls, locomotor time 1	0.5	0.7	2.6	0.1	-0.5	0.5	0.1	-0.2	-1.6	1.6	-0.0
Bouts of movement, locomotor time 1	0.3	0.4	1.8	0.1	0.1	-0.1	-0.3	0.4	0.9	-0.7	-1.3
Total resting periods, locomotor time 1	0.9	1.0	4.4	-0.2	0.1	-0.1	-0.5	0.2	1.4	-1.2	-2.1
Rest time, locomotor task time 1	0.4	0.6	2.2	-0.3	0.2	-0.2	-0.3	0.0	1.5	-1.2	-0.8
Distance moved, locomotor task time 1	0.1	0.3	1.0	-0.4	-0.4	0.4	-0.1	-0.3	-1.0	0.9	0.0
Vertical activity count, locomotor time 1	0.1	0.6	1.4	0.5	0.2	-0.2	0.7	0.5	-1.2	1.1	1.1
Time >=10cm from walls, locomotor time 2	0.3	0.9	2.7	-0.5	-0.6	0.7	-0.1	-0.2	-1.6	1.6	-0.8
Bouts of movement, locomotor time 2	0.8	2.7	3.4	1.6	1.7	-1.8	1.4	1.5	1.8	-1.8	-1.5
Total resting periods, locomotor time 2	0.9	3.5	4.4	1.8	2.0	-2.0	1.6	1.8	2.1	-2.1	-1.6
Rest time, locomotor task time 2	2.3	3.8	8.3	1.4	1.9	-1.9	1.2	1.2	2.9	-2.8	-1.7
Distance moved, locomotor task time 2	0.8	1.1	2.3	-1.0	-1.0	1.0	-0.6	-0.5	-1.5	1.4	0.7
Vertical activity count, locomotor time 2	0.3	0.6	2.6	-0.3	-0.3	0.3	0.0	-0.0	-1.1	1.0	1.6
Light reinforcement 1	0.0	0.1	0.3	-0.2	0.1	-0.0	0.0	0.5	0.0	-0.1	0.5
Light reinforcement 2	0.1	0.2	0.5	-0.7	-0.4	0.4	-0.5	-0.4	0.1	-0.2	-0.2
Bone: marrow area	0.2	0.4	0.5	-0.7	-0.7	0.7	-0.7	-0.7	-0.6	0.6	-0.4
Bone: maximum diameter	0.4	0.9	2.1	0.6	1.0	-1.0	0.5	0.6	1.4	-1.5	-0.2
Bone: maximum force	1.2	2.5	3.6	1.5	1.9	-1.9	1.5	1.6	1.7	-1.6	-0.2
Bone: maximum moment	1.0	1.8	2.8	1.4	1.7	-1.7	1.4	1.5	1.1	-1.1	0.1
Mean time between licks in bursts	0.9	5.1	7.2	-2.4	-2.7	2.7	-2.3	-2.3	-2.3	2.3	-0.1
Mean num. licks in bursts	0.3	0.8	1.0	-0.9	-1.0	1.0	-0.9	-0.9	-0.8	0.9	-0.2
Cd content in liver	0.8	0.8	2.7	0.4	-0.2	0.2	0.4	0.4	-1.7	1.7	0.8
Co content in liver	1.0	1.2	1.6	1.1	1.3	-1.3	1.1	1.1	1.2	-1.2	-0.0
Cu content in liver	0.3	0.4	0.5	0.7	0.7	-0.7	0.7	0.7	0.1	-0.2	0.7
Fe content in liver	1.0	1.3	1.8	-1.1	-1.3	1.3	-1.1	-1.2	-1.2	1.0	0.6
K content in liver	0.3	0.3	0.5	-0.7	-0.6	0.6	-0.7	-0.7	-0.3	0.2	0.2
Mg content in liver	1.8	2.0	3.0	-1.7	-1.6	1.6	-1.7	-1.7	-0.9	0.9	0.6
Mn content in liver	1.0	1.1	1.8	-1.3	-1.1	1.1	-1.3	-1.3	-0.4	0.3	1.1
Na content in liver	3.8	4.3	7.4	2.6	2.3	-2.3	2.7	2.7	0.1	-0.3	1.5
Rb content in liver	1.5	1.7	2.5	-1.0	-1.4	1.4	-1.2	-1.2	-1.5	1.6	-1.1
Se content in liver	0.6	0.7	2.9	-0.2	-0.5	0.5	-0.2	-0.3	-1.0	0.9	1.7
Sr content in liver	1.6	1.4	2.3	-0.9	-1.3	1.3	-0.9	-0.9	-1.4	1.5	1.2
Zn content in liver	1.1	1.3	1.8	-1.1	-1.3	1.3	-1.1	-1.1	-1.3	1.3	0.3
Bone: minimum diameter	0.4	0.7	1.1	0.7	0.9	-0.9	0.6	0.7	0.9	-1.0	1.0
Time in familiar zone, hab. session 1	0.3	0.4	1.2	-0.5	-0.0	0.0	-0.4	-0.4	1.1	-1.1	-0.3
Time in novel zone, hab. session 1	0.9	1.0	1.7	1.3	1.2	-1.2	1.3	1.3	0.3	-0.2	-0.3
Total zone transitions, hab. session 1	0.6	0.9	1.4	0.8	1.1	-1.1	0.7	0.8	1.2	-1.1	-0.5
Total locomotion distance, hab. session 1	0.2	0.2	0.7	0.2	0.4	-0.4	0.1	0.1	0.7	-0.8	-0.6
Locomotion velocity, hab. session 1	0.0	0.1	0.1	0.3	0.3	-0.3	0.1	0.1	0.3	-0.3	-0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.5	-0.3	0.3	-0.4	-0.4	0.2	-0.1	0.5
Time in novel zone, hab. session 2	0.2	0.3	1.6	0.3	0.3	-0.3	0.2	0.3	0.2	-0.3	-1.3
Total zone transitions, hab. session 2	0.2	0.3	0.6	0.8	0.6	-0.6	0.6	0.7	0.1	-0.1	0.3
Total locomotion distance, hab. session 2	0.2	0.2	0.5	0.4	0.5	-0.5	0.3	0.3	0.6	-0.7	0.1
Locomotion velocity, hab. session 2	0.4	0.5	0.7	0.7	0.8	-0.8	0.6	0.6	0.7	-0.8	0.2
Novel to familiar place preference ratio	0.3	0.4	1.3	-0.6	-0.3	0.3	-0.6	-0.7	0.5	-0.5	-1.1
Novelty place preference	0.3	0.4	1.5	-0.7	-0.4	0.4	-0.6	-0.7	0.3	-0.3	-1.2
Time in novel zone, NPP test	0.3	0.3	1.5	-0.5	-0.3	0.3	-0.5	-0.5	0.2	-0.2	-1.2
Total zone transitions, NPP test	0.0	0.1	0.3	0.2	0.1	-0.1	-0.1	-0.0	0.1	-0.1	-0.6
Total locomotion distance, NPP test	1.0	1.3	2.0	-1.2	-1.4	1.4	-1.4	-1.4	-0.9	0.8	-0.1
Locomotion velocity, NPP test	1.0	1.4	2.2	-1.3	-1.4	1.4	-1.5	-1.5	-0.8	0.7	0.0
Intraocular pressure	2.3	3.7	5.3	-1.8	-2.3	2.3	-2.2	-2.3	-1.6	1.6	0.4
Delta distance traveled before/after self-admin	1.1	1.2	1.7	1.1	1.2	-1.2	1.0	1.1	1.3	-1.1	-0.5
Delta ambulatory time before/after self-admin	0.7	1.1	1.8	0.9	1.1	-1.1	0.8	0.9	1.3	-1.3	-1.1
Parametrial fat weight	1.0	2.4	4.7	-2.0	-1.7	1.7	-1.9	-2.2	0.0	-0.0	0.8
Pavlov. Cond. lever latency	0.8	1.0	1.5	-1.2	-1.2	1.2	-1.2	-1.2	-0.6	0.7	0.2
Pavlov. Cond. magazine entry latency	0.3	0.3	0.7	0.7	0.6	-0.6	0.8	0.8	-0.1	0.2	0.1
Pavlov. Cond. change in total contacts	2.7	2.9	4.3	2.0	2.0	-2.0	2.0	2.1	1.1	-1.2	-0.3
Pavlov. Cond. index score	2.0	2.6	4.4	2.1	1.9	-1.9	2.1	2.1	0.6	-0.6	0.4
Pavlov. Cond. latency score	1.5	1.9	3.2	1.7	1.6	-1.6	1.8	1.7	0.5	-0.6	0.2
Pavlov. Cond. lever contacts	1.0	1.2	1.8	1.3	1.3	-1.3	1.3	1.3	0.5	-0.7	-0.3
Pavlov. Cond. magazine entry number	1.4	1.8	3.1	-1.7	-1.5	1.5	-1.8	-1.7	-0.3	0.3	-0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.0	-0.2	0.2	0.0	0.1	-0.5	0.4	0.2
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	5.1	2.2	2.0	-2.0	2.3	2.2	0.7	-0.7	0.3
Pavlov. Cond. response bias	1.6	1.9	3.1	1.8	1.6	-1.6	1.8	1.7	0.6	-0.6	-0.1
Pavlov. Cond. lever latency	0.8	1.1	3.0	-0.8	-0.3	0.3	-0.9	-0.8	1.3	-1.3	-1.7
Pavlov. Cond. magazine entry latency	1.0	1.4	2.3	1.5	1.4	-1.4	1.5	1.5	0.5	-0.4	0.6
Pavlov. Cond. change in total contacts	0.9	2.1	3.7	1.9	1.3	-1.4	1.9	1.9	-0.7	0.7	1.3
Pavlov. Cond. index score	0.9	1.5	2.6	1.5	1.1	-1.1	1.6	1.6	-0.5	0.5	1.1
Pavlov. Cond. latency score	0.9	1.5	2.4	1.5	1.0	-1.0	1.6	1.5	-0.7	0.7	1.3
Pavlov. Cond. lever contacts	0.6	0.9	1.9	0.8	0.3	-0.3	0.9	0.9	-1.2	1.2	1.4
Pavlov. Cond. magazine entry number	0.5	0.7	1.0	-1.0	-1.0	1.0	-1.0	-0.9	-0.6	0.5	-0.0
Pavlov. Cond. intertrial magazine entries	4.0	8.7	13.0	-3.6	-3.5	3.5	-3.5	-3.5	-1.7	1.6	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.6	2.9	1.6	1.3	-1.3	1.7	1.7	-0.2	0.3	0.9
Pavlov. Cond. response bias	0.8	1.1	2.0	1.3	0.9	-0.9	1.4	1.4	-0.5	0.5	1.0
Time in closed arm before self-admin	0.5	0.8	2.0	1.2	0.9	-0.9	1.0	1.4	-0.1	-0.0	0.5
Time in closed arm after self-admin	0.1	0.1	0.2	0.1	0.2	-0.2	0.4	0.5	0.1	-0.1	-0.1
Time in open arm before self-admin	0.6	0.8	1.6	-1.1	-0.8	0.8	-0.7	-1.3	-0.5	0.5	-1.1
Time in open arm after self-admin	0.3	0.4	1.2	0.1	-0.4	0.4	-0.2	-0.4	-1.0	1.1	0.3
Bone: periosteal estimation	0.1	0.1	0.3	0.1	0.4	-0.4	0.1	0.2	0.5	-0.5	0.4
Bone: periosteal perimeter	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.1	-0.1	0.1	-0.2	0.2
Bone: post-yield work	2.1	3.7	11.6	0.1	1.3	-1.3	0.1	0.2	3.4	-3.4	-1.7
Progressive ratio test 1 active lever presses	0.3	0.6	1.5	-0.9	-0.4	0.4	-0.8	-0.5	0.6	-0.7	-1.2
Progressive ratio test 1 breakpoint	0.3	0.5	1.5	-0.8	-0.2	0.2	-0.7	-0.3	0.8	-0.9	-1.2
Progressive ratio test 1 inactive lever presses	0.5	1.3	2.2	-1.1	-1.3	1.3	-1.1	-0.8	-1.5	1.3	0.7
Progressive ratio test 2 active lever presses	0.7	1.0	1.6	-1.0	-1.3	1.3	-1.2	-0.8	-0.8	0.8	-0.1
Progressive ratio test 2 breakpoint	0.6	0.8	1.3	-0.9	-1.2	1.2	-1.0	-0.6	-0.9	0.9	0.0
Progressive ratio test 2 inactive lever presses	0.9	2.8	4.0	-1.8	-2.0	2.0	-1.8	-1.5	-1.7	1.7	-0.7
Incentive Sensitization - Responses	0.7	1.9	4.3	-0.4	-1.4	1.4	-0.9	-0.7	-2.1	2.0	1.2
Incentive Sensitization - Breakpoint	0.9	2.1	4.8	-0.5	-1.5	1.4	-0.9	-0.6	-2.2	2.2	1.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.1	0.1	-0.1	0.1	-0.1	0.5	-0.4	0.0
Progressive ratio	0.3	0.8	1.9	1.4	0.8	-0.8	1.1	0.9	-0.4	0.4	0.8
Food seeking constrained by brief footshock	0.2	0.2	0.5	-0.5	0.0	0.0	-0.2	-0.2	0.7	-0.7	-0.5
Seeking ratio, punishment vs. effort	0.2	0.4	1.0	-0.9	-0.1	0.2	-0.5	-0.3	1.0	-1.0	-0.6
Retroperitoneal fat weight	0.1	0.6	1.0	-1.0	-0.8	0.8	-1.0	-0.9	0.4	-0.3	-0.6
Reaction time number correct	0.3	0.9	1.2	-0.9	-1.1	1.1	-0.9	-0.9	-1.0	1.0	0.4
Reaction time mean minus median	0.1	0.3	0.8	0.9	0.5	-0.5	0.9	0.3	-0.4	0.4	0.4
Reaction time mean minus median AUC	0.0	0.2	0.6	0.6	-0.0	-0.0	0.4	0.0	-0.8	0.8	0.5
Reaction time num false alarms	0.3	0.6	1.0	1.0	0.5	-0.5	1.0	0.6	-0.9	0.8	-0.6
Reaction time num false alarms AUC	0.2	0.5	1.2	1.1	0.6	-0.6	1.0	0.6	-0.6	0.5	-0.5
Reaction time trials correct on left	0.3	0.9	1.2	-0.9	-1.1	1.1	-0.9	-0.9	-1.0	1.0	0.4
Reaction time trials on left	0.3	1.1	1.5	-1.1	-1.2	1.2	-1.0	-1.1	-1.1	1.1	0.4
Reaction time mean	0.3	0.6	1.4	-0.3	-0.5	0.5	-0.0	-0.4	-1.1	1.2	1.2
Reaction time mean AUC	0.3	0.7	1.9	-0.1	-0.5	0.5	0.2	-0.2	-1.4	1.4	1.2
Median of all reaction times	0.5	0.8	1.6	-0.6	-0.8	0.8	-0.3	-0.5	-1.2	1.2	1.1
Reaction time omissions	2.4	4.0	5.6	-1.8	-2.4	2.3	-1.9	-2.3	-2.0	2.0	-0.4
Reaction time false alarm rate	0.8	1.1	2.0	1.4	1.1	-1.2	1.4	1.1	0.2	-0.2	-0.9
Reaction time premature initiation rate	0.6	0.9	1.3	0.8	1.1	-1.1	0.9	0.8	1.1	-1.1	0.5
Reaction time premature initiations	0.1	0.2	0.6	0.1	0.4	-0.4	0.3	0.1	0.5	-0.6	0.8
Std. dev. reaction times	0.0	0.1	0.2	-0.0	-0.1	0.1	0.2	-0.4	-0.5	0.5	0.3
Reaction time trials completed	0.3	1.1	1.5	-1.1	-1.2	1.2	-1.0	-1.1	-1.1	1.1	0.4
Reaction time trials AUC	0.4	1.3	1.8	-1.2	-1.3	1.3	-1.1	-1.1	-1.2	1.2	0.4
Run reversals in cocaine runway, females	0.2	0.2	1.1	-1.1	-0.1	0.2	-0.2	-0.5	0.1	-0.1	0.2
Run reversals in cocaine runway, males	2.9	3.2	4.6	2.0	2.1	-2.1	2.0	2.1	1.5	-1.5	0.4
Latency to leave start box in cocaine runway	1.3	1.8	3.1	-1.5	-1.7	1.7	-1.8	-1.3	-1.0	1.0	0.1
Latency to leave start box in cocaine runway, F	0.4	0.5	1.0	-0.3	-0.8	0.7	-0.9	-0.3	-0.6	0.6	1.0
Latency to leave start box in cocaine runway, M	2.2	2.1	3.0	-1.6	-1.7	1.7	-1.5	-1.4	-1.4	1.4	-0.2
Std. dev. time between licks in bursts	1.2	2.2	3.0	-1.5	-1.7	1.7	-1.5	-1.5	-1.6	1.6	0.1
Total sessions with >9 infusions	0.7	0.8	1.2	-0.9	-1.1	1.1	-1.1	-0.7	-1.0	0.8	-0.1
Short access day 1 total inactive lever presses	0.1	0.2	0.8	-0.2	-0.2	0.2	-0.4	-0.1	0.7	-0.4	-0.9
Short access day 10 total inactive lever presses	0.1	0.4	0.6	-0.6	-0.7	0.7	-0.8	-0.7	-0.2	0.4	-0.1
Short access day 1 total infusions	1.1	2.2	4.4	-1.9	-1.8	1.8	-2.1	-1.6	-0.5	0.4	-0.5
Short access day 10 total infusions	0.1	0.2	0.7	-0.3	0.2	-0.1	-0.1	0.2	0.6	-0.7	-0.8
Short access total infusions	0.4	0.5	1.1	-1.0	-0.8	0.8	-1.0	-0.6	0.0	-0.1	-0.8
Short access day 1 locomotion	0.2	0.3	0.8	0.1	-0.4	0.4	-0.3	-0.4	-0.9	0.7	0.6
Short access day 10 total locomotion	0.1	0.3	1.5	0.5	-0.1	0.0	0.2	0.3	-0.6	0.3	1.2
Short access total locomotion	0.1	0.2	0.8	0.5	0.0	-0.0	0.2	0.2	-0.6	0.5	0.9
One hour access (0.3 mA shock)	0.4	0.4	0.9	-0.8	-0.4	0.4	-0.8	-0.5	1.0	-0.8	-0.3
Compulsive drug intake	0.1	0.2	1.3	0.1	0.0	-0.0	0.1	-0.0	-0.0	0.0	1.2
One hour access (shock baseline)	0.3	0.9	1.7	-1.3	-1.0	1.0	-1.3	-0.8	0.3	-0.1	-0.9
Social response proportion	2.0	2.6	4.7	-1.6	-1.8	1.8	-1.9	-2.2	-0.6	0.7	-1.4
Social responses	2.4	3.2	5.8	-2.2	-2.1	2.1	-2.2	-2.4	-0.6	0.7	-0.5
Social time	1.4	2.1	5.7	-0.4	-1.2	1.2	-0.6	-0.8	-2.4	2.4	1.3
Soleus weight	0.5	1.3	1.7	1.2	1.3	-1.3	1.1	1.2	1.3	-1.2	0.3
Bone: stiffness	0.9	1.6	2.3	1.4	1.5	-1.5	1.4	1.5	0.9	-0.9	-0.9
Tibialis anterior weight	4.9	16.9	29.4	5.4	4.8	-4.8	5.2	5.3	1.4	-1.4	0.4
Time to tail flick, vehicle, before self-admin	1.1	1.3	2.2	1.0	1.5	-1.4	1.2	1.3	1.0	-1.1	-0.3
Time to tail flick, vehicle, after self-admin	0.6	1.2	2.2	0.9	1.3	-1.3	1.5	0.9	0.9	-1.0	-0.0
Time to tail flick, test, before self-admin	0.2	0.2	1.2	-0.1	-0.2	0.2	-0.1	-0.3	-0.5	0.5	1.1
Time to tail flick, test, after self-admin	4.5	4.7	6.7	-2.5	-2.6	2.6	-2.6	-2.6	-1.7	1.6	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.9	-0.8	0.8	-0.5	-0.8	-0.5	0.4	0.0
Delta time to tail flick, test, before/after SA	2.4	2.9	4.8	-2.2	-2.0	2.1	-2.0	-1.8	-1.2	1.1	-0.6
Tibia length	0.8	2.2	5.8	1.2	0.2	-0.3	1.2	1.4	-2.2	2.4	1.4
Ambulatory time before self-admin	0.0	0.1	0.3	-0.2	-0.3	0.3	-0.1	-0.2	-0.6	0.5	-0.1
Ambulatory time after self-admin	0.7	1.1	1.6	1.3	1.2	-1.2	1.2	1.3	0.7	-0.7	-0.6
Bone: tissue strength	0.6	0.6	0.8	-0.6	-0.8	0.8	-0.6	-0.6	-0.9	0.9	0.9
Total heroin consumption	0.7	0.8	1.5	1.2	1.1	-1.1	1.1	0.8	0.6	-0.7	-0.5
Bone: trabecular number	1.3	2.4	3.1	-1.5	-1.8	1.8	-1.5	-1.6	-1.7	1.6	0.3
Bone: trabecular spacing	2.8	4.0	5.7	2.1	2.4	-2.4	2.1	2.0	2.0	-2.0	-0.2
Bone: trabecular thickness	0.2	0.3	0.4	0.6	0.6	-0.6	0.6	0.6	0.3	-0.4	0.2
Bone: trabecular tissue density	2.2	3.9	5.7	2.4	2.4	-2.4	2.4	2.4	1.1	-1.2	-0.4
Water consumed over 24 hours	0.3	0.5	1.0	1.0	0.8	-0.8	1.0	1.0	0.0	0.0	0.1
Number of responses in last shaping day	0.9	1.2	2.0	1.4	1.2	-1.3	0.9	0.8	1.1	-1.4	-0.4