Hub : Genes

LOC103692984

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	intron excision ratio	chr7_132330480_132337695	0.74	0.18	9.4e-04	0.12	0.11	0.03	0.1	3.2e-04	9.0e-04	4.4e-02	1.4e-03
2	RMTg	intron excision ratio	chr7_132335799_132337695	0.72	0.19	2.9e-04	0.15	0.13	0.06	0.12	8.8e-05	2.5e-04	1.2e-02	3.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.1	0.1	0.1	-0.3	0.3
Area under the delay curve	0.0	0.0	0.0	-0.0	0.0
BMI with tail	3.4	10.9	10.9	-3.3	3.3
BMI without tail	0.6	1.2	1.2	-1.1	1.1
Body weight	0.9	3.8	3.8	-1.9	1.9
Weight adjusted by age	0.8	0.9	0.9	-1.0	1.0
Bone surface	0.2	0.3	0.3	-0.6	0.6
Bone volume	0.3	0.5	0.5	-0.7	0.7
Breakpoint value in progressive ratio session	0.0	0.1	0.1	0.2	-0.2
Number of licking bursts	0.1	0.1	0.1	-0.3	0.3
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, session 1	2.2	2.4	2.4	1.5	-1.5
Locomotion distance, session 1	0.1	0.1	0.1	0.4	-0.4
Locomotion velocity, session 2	1.4	1.6	1.6	1.3	-1.3
Locomotion distance, session 2	0.3	0.5	0.5	0.7	-0.7
Locomotion velocity, session 3	3.3	3.8	3.8	2.0	-2.0
Locomotion distance, session 3	4.5	4.9	4.9	2.2	-2.2
Stereotopy head waving bouts, day 3	2.2	2.6	2.6	-1.6	1.6
Stereotopy head waving duration, day 3	0.2	0.2	0.2	-0.5	0.5
Locomotion velocity, session 7	1.8	1.9	1.9	1.4	-1.4
Locomotion distance, session 7	4.0	5.1	5.1	2.3	-2.3
Stereotopy head waving bouts, day 7	4.2	4.7	4.7	-2.2	2.2
Stereotopy head waving duration, day 7	3.5	4.3	4.3	-2.1	2.1
Locomotion velocity, session 8	0.0	0.0	0.0	0.2	-0.2
Locomotion distance, session 8	0.9	1.3	1.3	1.1	-1.1
Degree of sensitization distance	0.3	0.3	0.3	-0.6	0.6
Degree of sensitization stereotypy	3.0	3.3	3.3	-1.8	1.8
Conditioned locomotion	0.0	0.0	0.0	0.1	-0.1
Cocaine response after cond. corrected	0.4	0.5	0.5	-0.7	0.7
Cocaine response after cond. not corrected	0.1	0.1	0.1	-0.3	0.3
Cocaine response before conditioning	1.7	2.1	2.1	1.4	-1.4
Saline control response	0.1	0.1	0.1	0.3	-0.3
Bone: connectivity density	0.1	0.2	0.2	0.5	-0.5
Bone: cortical apparent density	1.8	2.4	2.4	-1.5	1.5
Bone: cortical area	0.4	0.6	0.6	-0.8	0.8
Bone: cortical porosity	1.6	1.7	1.7	1.3	-1.3
Bone: cortical porosity	1.5	1.6	1.6	1.3	-1.3
Bone: cortical thickness	0.1	0.1	0.1	-0.4	0.4
Bone: cortical thickness	0.3	0.4	0.4	0.6	-0.6
Bone: cortical tissue density	1.6	2.0	2.0	-1.4	1.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.4	0.6	-0.6
Condit. Reinf. active responses	0.3	0.3	0.3	0.6	-0.6
Condit. Reinf. inactive responses	0.2	0.2	0.2	0.5	-0.5
Incentive salience index mean	0.0	0.0	0.0	-0.0	0.0
Condit. Reinf. lever presses	0.7	0.9	0.9	-0.9	0.9
Condit. Reinf. active minus inactive responses	1.0	1.2	1.2	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.4	-0.6	0.6
Condit. Reinf. active responses	0.8	1.1	1.1	-1.1	1.1
Condit. Reinf. inactive responses	0.1	0.2	0.2	-0.4	0.4
Condit. Reinf. lever presses	0.4	0.6	0.6	0.8	-0.8
Condit. Reinf. lever reinforcers received	0.2	0.3	0.3	-0.5	0.5
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.1	0.1
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.1	-0.1
Conditioned locomotion	0.5	0.6	0.6	0.8	-0.8
Patch foraging indifference point 0 sec	0.2	0.4	0.4	0.6	-0.6
Patch foraging indifference point AUC	0.4	0.4	0.4	-0.7	0.7
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.0	0.0
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	0.1	-0.1
Delay disc. indifference point, 2s delay	6.3	7.0	7.0	-2.6	2.6
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	-0.1
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.1	0.1
Delay disc. indifference point, 8s delay	0.3	0.4	0.4	0.6	-0.6
Indifference point function ln k	0.0	0.0	0.0	-0.2	0.2
Indifference point function log k	0.0	0.0	0.0	-0.2	0.2
Patch foraging total patch changes 0 sec	0.6	0.9	0.9	0.9	-0.9
Patch foraging total patch changes 12 sec	0.1	0.1	0.1	0.3	-0.3
Patch foraging total patch changes 18 sec	0.5	0.6	0.6	0.8	-0.8
Patch foraging total patch changes 24 sec	0.2	0.2	0.2	0.4	-0.4
Patch foraging total patch changes 6 sec	0.1	0.1	0.1	0.3	-0.3
Patch foraging time to switch 0 sec	0.2	0.3	0.3	-0.5	0.5
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.1	0.1
Patch foraging water rate 12 sec	0.2	0.4	0.4	0.6	-0.6
Patch foraging water rate 18 sec	0.0	0.0	0.0	-0.1	0.1
Patch foraging water rate 24 sec	0.2	0.3	0.3	-0.5	0.5
Patch foraging water rate 6 sec	0.1	0.2	0.2	0.4	-0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.2	0.2
Distance traveled before self-admin	0.2	0.2	0.2	0.4	-0.4
Distance traveled after self-admin	1.5	1.7	1.7	1.3	-1.3
Extensor digitorum longus weight	8.1	31.9	31.9	-5.7	5.7
Bone: elastic displacement	4.4	4.9	4.9	2.2	-2.2
Bone: elastic work	2.4	3.2	3.2	1.8	-1.8
Bone: endosteal estimation	0.2	0.4	0.4	-0.7	0.7
Bone: endosteal perimeter	0.8	1.6	1.6	-1.3	1.3
Epididymis fat weight	2.7	6.2	6.2	2.5	-2.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	-0.3
Delta time in open arm before/after self-admin	4.0	3.9	3.9	2.0	-2.0
Diff in mean of infusions in LGA sessions	1.3	1.4	1.4	-1.2	1.2
Delay discount exponential model param	0.0	0.0	0.0	0.1	-0.1
Extinction: sum of active levers before priming	0.8	0.8	0.8	-0.9	0.9
Active lever presses in extinction session 6	0.1	0.1	0.1	0.2	-0.2
Bone: final force	0.0	0.1	0.1	-0.3	0.3
Bone: final moment	0.0	0.0	0.0	-0.2	0.2
Food consumed during 24 hour testing period	0.7	0.8	0.8	0.9	-0.9
Glucose	0.1	0.1	0.1	0.3	-0.3
Heart weight	0.0	0.0	0.0	0.1	-0.1
Delay discount hyperbolic model param	0.2	0.2	0.2	0.5	-0.5
Intermittent access intake day 1-15 change	0.9	0.9	0.9	0.9	-0.9
Intermittent access intake escalation	1.2	1.2	1.2	1.1	-1.1
Intermittent access intake escalation 2	1.1	1.1	1.1	1.0	-1.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.0
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.3	0.5	-0.5
Intermitt. access escalation Index	0.3	0.3	0.3	-0.5	0.5
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.1
Intermittent access day 15 total infusions	0.4	0.4	0.4	0.6	-0.6
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.2	0.4	-0.4
Intermittent access total infusions	0.1	0.1	0.1	0.4	-0.4
Intermittent access day 1 locomotion	0.7	0.8	0.8	0.9	-0.9
Intermittent access day 15 total locomotion	2.6	2.8	2.8	1.7	-1.7
Intermittent access total locomotion	1.2	1.4	1.4	1.2	-1.2
Intermittent access standard deviation	1.2	1.3	1.3	1.1	-1.1
Left kidney weight	0.0	0.1	0.1	-0.3	0.3
Right kidney weight	0.3	0.8	0.8	-0.9	0.9
Cocaine induced anxiety	0.4	0.4	0.4	0.6	-0.6
Post-drug Anxiety	0.0	0.0	0.0	0.0	-0.0
Baseline Anxiety	0.0	0.0	0.0	-0.2	0.2
Tail length	0.3	0.9	0.9	0.9	-0.9
Length with tail	0.0	0.1	0.1	0.4	-0.4
Length without tail	0.1	0.2	0.2	-0.5	0.5
Times rat made contact with spout	0.6	0.7	0.7	0.9	-0.9
Lifetime Intake	0.6	0.7	0.7	0.8	-0.8
Liver weight, left	0.3	0.4	0.4	0.7	-0.7
Liver weight, right	0.3	0.6	0.6	0.8	-0.8
Locomotor activity	0.2	0.3	0.3	0.6	-0.6
Locomotor testing distance	0.8	1.3	1.3	1.1	-1.1
Locomotor testing rearing	0.7	1.1	1.1	1.0	-1.0
Locomotion in novel chamber	1.4	1.8	1.8	-1.3	1.3
Locomotion in novel chamber post-restriction	0.4	0.5	0.5	0.7	-0.7
Fecal boli incidents, locomotor time 1	3.4	3.7	3.7	1.9	-1.9
Change in fecal boli incidents, locomotor task	1.6	1.5	1.5	-1.2	1.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.2	0.5	-0.5
Bouts of movement, locomotor time 1	0.2	0.2	0.2	0.4	-0.4
Total resting periods, locomotor time 1	0.4	0.5	0.5	0.7	-0.7
Rest time, locomotor task time 1	0.5	0.6	0.6	0.8	-0.8
Distance moved, locomotor task time 1	0.6	0.6	0.6	-0.8	0.8
Vertical activity count, locomotor time 1	2.0	2.1	2.1	-1.4	1.4
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.5	0.7	-0.7
Bouts of movement, locomotor time 2	1.2	1.3	1.3	-1.1	1.1
Total resting periods, locomotor time 2	1.9	2.0	2.0	-1.4	1.4
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.3	0.3
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.1	0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.2	0.2
Light reinforcement 1	0.0	0.0	0.0	0.0	-0.0
Light reinforcement 2	0.1	0.1	0.1	-0.3	0.3
Bone: marrow area	0.2	0.4	0.4	-0.6	0.6
Bone: maximum diameter	0.4	0.8	0.8	-0.9	0.9
Bone: maximum force	0.4	0.7	0.7	-0.8	0.8
Bone: maximum moment	0.3	0.5	0.5	-0.7	0.7
Mean time between licks in bursts	1.0	1.5	1.5	1.2	-1.2
Mean num. licks in bursts	1.1	1.3	1.3	1.2	-1.2
Cd content in liver	0.4	0.4	0.4	0.6	-0.6
Co content in liver	0.1	0.1	0.1	0.3	-0.3
Cu content in liver	0.0	0.0	0.0	-0.0	0.0
Fe content in liver	0.4	0.5	0.5	0.7	-0.7
K content in liver	0.1	0.1	0.1	0.3	-0.3
Mg content in liver	0.3	0.3	0.3	0.5	-0.5
Mn content in liver	0.1	0.1	0.1	-0.3	0.3
Na content in liver	0.0	0.0	0.0	-0.0	0.0
Rb content in liver	0.7	0.8	0.8	0.9	-0.9
Se content in liver	0.4	0.5	0.5	0.7	-0.7
Sr content in liver	1.6	1.5	1.5	1.2	-1.2
Zn content in liver	1.1	1.2	1.2	1.1	-1.1
Bone: minimum diameter	0.5	0.9	0.9	-0.9	0.9
Time in familiar zone, hab. session 1	0.3	0.3	0.3	0.5	-0.5
Time in novel zone, hab. session 1	2.2	2.2	2.2	-1.5	1.5
Total zone transitions, hab. session 1	0.8	1.1	1.1	-1.0	1.0
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.1	0.3	-0.3
Time in familiar zone, hab. session 2	0.2	0.2	0.2	0.4	-0.4
Time in novel zone, hab. session 2	0.6	0.6	0.6	-0.8	0.8
Total zone transitions, hab. session 2	0.1	0.1	0.1	0.4	-0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.1	0.3	-0.3
Locomotion velocity, hab. session 2	0.2	0.3	0.3	0.5	-0.5
Novel to familiar place preference ratio	1.7	1.8	1.8	-1.3	1.3
Novelty place preference	1.3	1.3	1.3	-1.1	1.1
Time in novel zone, NPP test	1.5	1.5	1.5	-1.2	1.2
Total zone transitions, NPP test	0.2	0.3	0.3	0.5	-0.5
Total locomotion distance, NPP test	0.9	1.2	1.2	1.1	-1.1
Locomotion velocity, NPP test	1.1	1.6	1.6	1.3	-1.3
Intraocular pressure	1.0	1.4	1.4	1.2	-1.2
Delta distance traveled before/after self-admin	2.5	2.7	2.7	1.6	-1.6
Delta ambulatory time before/after self-admin	2.9	3.2	3.2	1.8	-1.8
Parametrial fat weight	2.4	4.7	4.7	2.2	-2.2
Pavlov. Cond. lever latency	1.0	1.2	1.2	1.1	-1.1
Pavlov. Cond. magazine entry latency	2.8	3.6	3.6	-1.9	1.9
Pavlov. Cond. change in total contacts	3.0	3.2	3.2	-1.8	1.8
Pavlov. Cond. index score	3.2	4.0	4.0	-2.0	2.0
Pavlov. Cond. latency score	2.6	3.3	3.3	-1.8	1.8
Pavlov. Cond. lever contacts	0.9	1.1	1.1	-1.0	1.0
Pavlov. Cond. magazine entry number	1.3	1.6	1.6	1.3	-1.3
Pavlov. Cond. intertrial magazine entries	1.7	2.0	2.0	1.4	-1.4
Pavlov. Cond. lever-magazine prob. diff.	3.2	3.9	3.9	-2.0	2.0
Pavlov. Cond. response bias	1.3	1.6	1.6	-1.3	1.3
Pavlov. Cond. lever latency	1.1	1.5	1.5	-1.2	1.2
Pavlov. Cond. magazine entry latency	2.2	2.6	2.6	1.6	-1.6
Pavlov. Cond. change in total contacts	1.2	1.6	1.6	-1.3	1.3
Pavlov. Cond. index score	1.2	1.6	1.6	1.3	-1.3
Pavlov. Cond. latency score	1.1	1.4	1.4	1.2	-1.2
Pavlov. Cond. lever contacts	1.6	2.2	2.2	1.5	-1.5
Pavlov. Cond. magazine entry number	0.6	0.7	0.7	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.3	1.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	0.9	0.9	-0.9
Pavlov. Cond. response bias	1.8	2.5	2.5	1.6	-1.6
Time in closed arm before self-admin	1.4	1.6	1.6	-1.3	1.3
Time in closed arm after self-admin	1.5	1.5	1.5	-1.2	1.2
Time in open arm before self-admin	2.4	2.6	2.6	-1.6	1.6
Time in open arm after self-admin	0.0	0.0	0.0	-0.0	0.0
Bone: periosteal estimation	0.3	0.7	0.7	-0.8	0.8
Bone: periosteal perimeter	1.8	3.1	3.1	-1.7	1.7
Bone: post-yield work	0.2	0.3	0.3	-0.5	0.5
Progressive ratio test 1 active lever presses	1.2	1.2	1.2	1.1	-1.1
Progressive ratio test 1 breakpoint	0.7	0.8	0.8	0.9	-0.9
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	0.3	-0.3
Progressive ratio test 2 active lever presses	0.3	0.4	0.4	0.6	-0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.2	0.5	-0.5
Progressive ratio test 2 inactive lever presses	0.6	0.7	0.7	0.8	-0.8
Incentive Sensitization - Responses	0.4	0.4	0.4	-0.6	0.6
Incentive Sensitization - Breakpoint	0.6	0.6	0.6	-0.8	0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.2	-0.2
Progressive ratio	0.2	0.3	0.3	0.5	-0.5
Food seeking constrained by brief footshock	0.7	0.9	0.9	0.9	-0.9
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.1	-0.1
Retroperitoneal fat weight	1.8	5.8	5.8	2.4	-2.4
Reaction time number correct	0.1	0.2	0.2	0.4	-0.4
Reaction time mean minus median	0.0	0.0	0.0	0.2	-0.2
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.1	0.1
Reaction time num false alarms	0.0	0.0	0.0	0.2	-0.2
Reaction time num false alarms AUC	0.0	0.0	0.0	-0.0	0.0
Reaction time trials correct on left	0.1	0.2	0.2	0.4	-0.4
Reaction time trials on left	0.1	0.2	0.2	0.4	-0.4
Reaction time mean	0.0	0.0	0.0	-0.0	0.0
Reaction time mean AUC	0.0	0.0	0.0	-0.1	0.1
Median of all reaction times	0.0	0.0	0.0	-0.1	0.1
Reaction time omissions	1.0	1.3	1.3	1.2	-1.2
Reaction time false alarm rate	0.2	0.3	0.3	-0.5	0.5
Reaction time premature initiation rate	2.2	2.9	2.9	1.7	-1.7
Reaction time premature initiations	2.3	3.2	3.2	1.8	-1.8
Std. dev. reaction times	0.0	0.0	0.0	0.0	-0.0
Reaction time trials completed	0.1	0.2	0.2	0.4	-0.4
Reaction time trials AUC	0.1	0.1	0.1	0.3	-0.3
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.1	-0.1
Run reversals in cocaine runway, males	2.6	2.5	2.5	-1.6	1.6
Latency to leave start box in cocaine runway	0.4	0.4	0.4	-0.6	0.6
Latency to leave start box in cocaine runway, F	0.5	0.5	0.5	-0.7	0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	-0.4	0.4
Std. dev. time between licks in bursts	1.1	1.3	1.3	1.1	-1.1
Total sessions with >9 infusions	0.1	0.1	0.1	0.3	-0.3
Short access day 1 total inactive lever presses	0.7	0.7	0.7	0.9	-0.9
Short access day 10 total inactive lever presses	0.1	0.1	0.1	0.3	-0.3
Short access day 1 total infusions	0.1	0.1	0.1	0.3	-0.3
Short access day 10 total infusions	0.3	0.3	0.3	0.6	-0.6
Short access total infusions	0.8	0.9	0.9	0.9	-0.9
Short access day 1 locomotion	0.0	0.0	0.0	0.1	-0.1
Short access day 10 total locomotion	0.0	0.0	0.0	-0.0	0.0
Short access total locomotion	0.0	0.0	0.0	0.0	-0.0
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.3	0.3
Compulsive drug intake	0.3	0.3	0.3	-0.6	0.6
One hour access (shock baseline)	0.2	0.2	0.2	-0.4	0.4
Social response proportion	2.3	2.5	2.5	1.6	-1.6
Social responses	0.4	0.6	0.6	0.8	-0.8
Social time	1.1	1.5	1.5	1.2	-1.2
Soleus weight	0.0	0.1	0.1	-0.2	0.2
Bone: stiffness	1.7	2.8	2.8	-1.7	1.7
Tibialis anterior weight	11.8	40.2	40.2	-6.3	6.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.1	0.1
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.5	-0.7	0.7
Time to tail flick, test, before self-admin	0.8	0.8	0.8	-0.9	0.9
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.0	-0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	-0.3
Tibia length	0.0	0.0	0.0	0.0	-0.0
Ambulatory time before self-admin	0.4	0.4	0.4	0.6	-0.6
Ambulatory time after self-admin	2.8	3.1	3.1	1.8	-1.8
Bone: tissue strength	0.8	0.7	0.7	-0.9	0.9
Total heroin consumption	0.4	0.5	0.5	0.7	-0.7
Bone: trabecular number	0.3	0.5	0.5	0.7	-0.7
Bone: trabecular spacing	0.2	0.3	0.3	-0.6	0.6
Bone: trabecular thickness	0.2	0.2	0.2	-0.5	0.5
Bone: trabecular tissue density	3.0	4.2	4.2	-2.1	2.1
Water consumed over 24 hours	1.0	1.3	1.3	1.1	-1.1
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	0.2