Hub : Genes

LOC103692984

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg intron excision ratio chr7_134209193_134216407 0.53 0.29 5.9e-03 0.08 0.07 0.06 0.08 4.0e-03 4.9e-03 8.5e-03 4.4e-03
2 RMTg intron excision ratio chr7_134214512_134216407 0.52 0.28 3.5e-03 0.08 0.08 0.09 0.08 3.6e-03 3.4e-03 2.9e-03 3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.20.2-0.40.5
Area under the delay curve0.00.00.0-0.0-0.2
BMI with tail1.75.87.3-2.72.1
BMI without tail0.52.63.0-1.71.5
Body weight0.62.73.2-1.81.5
Weight adjusted by age0.92.62.9-1.51.7
Bone surface0.20.30.4-0.60.5
Bone volume0.40.70.8-0.80.9
Breakpoint value in progressive ratio session0.00.00.0-0.2-0.2
Number of licking bursts0.00.10.2-0.40.3
Context. condit. distance diff. score0.10.10.20.2-0.5
Locomotion velocity, session 11.21.42.61.6-0.4
Locomotion distance, session 10.10.10.20.4-0.0
Locomotion velocity, session 20.91.11.91.4-0.6
Locomotion distance, session 20.30.40.60.8-0.3
Locomotion velocity, session 32.83.24.02.0-1.5
Locomotion distance, session 33.64.25.22.3-1.8
Stereotopy head waving bouts, day 32.63.13.1-1.81.7
Stereotopy head waving duration, day 30.40.50.7-0.60.9
Locomotion velocity, session 71.92.12.51.3-1.6
Locomotion distance, session 73.94.95.22.2-2.3
Stereotopy head waving bouts, day 74.55.25.7-2.42.2
Stereotopy head waving duration, day 72.93.53.9-2.01.8
Locomotion velocity, session 80.00.10.10.3-0.1
Locomotion distance, session 81.11.71.71.3-1.3
Degree of sensitization distance0.20.30.5-0.70.2
Degree of sensitization stereotypy2.62.93.2-1.81.6
Conditioned locomotion0.00.00.00.2-0.0
Cocaine response after cond. corrected0.20.30.3-0.60.5
Cocaine response after cond. not corrected0.00.00.1-0.2-0.0
Cocaine response before conditioning1.62.02.21.3-1.5
Saline control response0.10.20.20.4-0.5
Bone: connectivity density0.10.20.20.4-0.3
Bone: cortical apparent density1.82.93.1-1.81.6
Bone: cortical area0.40.60.8-0.90.7
Bone: cortical porosity1.01.01.41.2-0.8
Bone: cortical porosity1.11.21.51.2-0.9
Bone: cortical thickness0.20.30.4-0.60.4
Bone: cortical thickness0.40.50.60.8-0.7
Bone: cortical tissue density1.72.72.8-1.71.6
Condit. Reinf. active minus inactive responses0.00.00.00.1-0.1
Condit. Reinf. active-inactive response ratio0.30.40.50.4-0.7
Condit. Reinf. active responses0.10.10.20.4-0.1
Condit. Reinf. inactive responses0.20.20.30.50.4
Incentive salience index mean0.00.00.1-0.20.2
Condit. Reinf. lever presses0.50.70.8-0.90.8
Condit. Reinf. active minus inactive responses0.60.91.1-1.00.9
Condit. Reinf. active-inactive response ratio0.20.30.3-0.50.5
Condit. Reinf. active responses0.60.80.9-1.00.9
Condit. Reinf. inactive responses0.10.20.3-0.40.5
Condit. Reinf. lever presses0.71.11.40.9-1.2
Condit. Reinf. lever reinforcers received0.10.20.2-0.40.4
Conditioned reinforcement - actives0.10.50.60.6-0.8
Conditioned reinforcement - inactives0.51.21.90.8-1.4
Conditioned locomotion0.81.11.31.0-1.2
Patch foraging indifference point 0 sec0.20.70.80.7-0.9
Patch foraging indifference point AUC0.10.20.3-0.6-0.4
Delay disc. indifference point, 0s delay0.10.10.1-0.0-0.4
Delay disc. indifference point, 16s delay0.10.10.10.2-0.4
Delay disc. indifference point, 2s delay5.56.27.1-2.72.3
Delay disc. indifference point, 24s delay0.00.00.00.1-0.1
Delay disc. indifference point, 4s delay0.00.00.0-0.2-0.1
Delay disc. indifference point, 8s delay0.30.50.60.7-0.7
Indifference point function ln k0.30.81.5-0.21.2
Indifference point function log k0.30.81.5-0.21.2
Patch foraging total patch changes 0 sec0.41.11.11.1-1.1
Patch foraging total patch changes 12 sec0.40.61.10.3-1.0
Patch foraging total patch changes 18 sec0.51.11.70.7-1.3
Patch foraging total patch changes 24 sec0.31.11.90.5-1.4
Patch foraging total patch changes 6 sec0.50.81.40.4-1.2
Patch foraging time to switch 0 sec0.10.40.5-0.50.7
Patch foraging water rate 0 sec0.00.10.1-0.1-0.3
Patch foraging water rate 12 sec0.10.30.40.6-0.4
Patch foraging water rate 18 sec0.00.00.0-0.1-0.1
Patch foraging water rate 24 sec0.20.30.4-0.70.3
Patch foraging water rate 6 sec0.10.10.20.4-0.4
Seeking ratio, delayed vs. immediate footshock0.00.00.00.2-0.1
Distance traveled before self-admin0.30.61.00.5-1.0
Distance traveled after self-admin2.64.65.12.0-2.3
Extensor digitorum longus weight7.530.132.6-5.75.3
Bone: elastic displacement3.13.94.52.1-1.8
Bone: elastic work2.33.03.11.8-1.7
Bone: endosteal estimation0.10.20.3-0.50.3
Bone: endosteal perimeter0.51.11.3-1.11.0
Epididymis fat weight1.57.37.42.7-2.7
Delta time in closed arm before/after self-admin0.30.30.30.4-0.6
Delta time in open arm before/after self-admin1.92.22.51.6-1.4
Diff in mean of infusions in LGA sessions0.61.01.0-1.01.0
Delay discount exponential model param0.00.00.00.20.0
Extinction: sum of active levers before priming0.81.21.4-1.21.0
Active lever presses in extinction session 60.90.91.40.7-1.2
Bone: final force0.10.10.2-0.4-0.1
Bone: final moment0.10.10.1-0.4-0.3
Food consumed during 24 hour testing period0.40.80.90.9-0.8
Glucose0.10.20.40.6-0.3
Heart weight0.40.60.80.6-0.9
Delay discount hyperbolic model param0.10.10.20.4-0.1
Intermittent access intake day 1-15 change0.10.70.80.8-0.9
Intermittent access intake escalation0.00.10.20.3-0.4
Intermittent access intake escalation 20.40.70.80.8-0.9
Intermitt. access day 1 inactive lever presses0.00.20.3-0.6-0.2
Intermitt. access day 15 inactive lever presses0.00.00.0-0.0-0.2
Intermitt. access escalation Index0.41.11.3-1.11.0
Intermittent access day 1 total infusions0.10.30.50.3-0.7
Intermittent access day 15 total infusions0.00.00.1-0.0-0.2
Intermittent access terminal intake (last 3 days)0.00.10.10.2-0.3
Intermittent access total infusions0.10.10.30.1-0.5
Intermittent access day 1 locomotion0.50.91.40.6-1.2
Intermittent access day 15 total locomotion1.14.14.81.8-2.2
Intermittent access total locomotion1.72.12.61.3-1.6
Intermittent access standard deviation0.52.94.01.3-2.0
Left kidney weight0.00.20.3-0.60.2
Right kidney weight0.21.11.1-1.01.0
Cocaine induced anxiety0.10.10.30.00.5
Post-drug Anxiety0.10.20.30.6-0.0
Baseline Anxiety0.00.00.0-0.10.2
Tail length0.10.30.60.8-0.1
Length with tail0.00.10.20.10.4
Length without tail0.00.10.1-0.30.3
Times rat made contact with spout0.60.70.91.0-0.7
Lifetime Intake0.70.81.40.5-1.2
Liver weight, left0.00.00.0-0.10.0
Liver weight, right0.10.20.30.2-0.5
Locomotor activity0.30.50.60.7-0.8
Locomotor testing distance0.51.11.21.0-1.1
Locomotor testing rearing0.41.51.81.1-1.3
Locomotion in novel chamber0.70.91.1-1.00.9
Locomotion in novel chamber post-restriction0.51.52.40.7-1.5
Fecal boli incidents, locomotor time 11.33.43.61.9-1.8
Change in fecal boli incidents, locomotor task1.61.72.0-1.11.4
Time >=10cm from walls, locomotor time 10.10.20.30.60.1
Bouts of movement, locomotor time 10.10.10.20.4-0.1
Total resting periods, locomotor time 10.20.20.50.7-0.2
Rest time, locomotor task time 10.30.50.70.8-0.6
Distance moved, locomotor task time 10.10.40.7-0.80.3
Vertical activity count, locomotor time 10.21.62.1-1.51.0
Time >=10cm from walls, locomotor time 20.20.40.50.7-0.6
Bouts of movement, locomotor time 20.41.31.6-1.31.0
Total resting periods, locomotor time 20.52.02.3-1.51.3
Rest time, locomotor task time 20.10.10.2-0.20.4
Distance moved, locomotor task time 20.00.00.1-0.30.1
Vertical activity count, locomotor time 20.00.00.1-0.30.1
Light reinforcement 10.00.20.30.1-0.6
Light reinforcement 20.00.00.1-0.30.1
Bone: marrow area0.10.10.2-0.50.3
Bone: maximum diameter0.30.70.7-0.80.8
Bone: maximum force0.40.81.2-1.10.7
Bone: maximum moment0.30.60.9-0.90.5
Mean time between licks in bursts0.21.31.81.3-0.9
Mean num. licks in bursts0.51.41.61.3-1.1
Cd content in liver0.10.10.20.4-0.3
Co content in liver0.10.10.1-0.30.3
Cu content in liver0.00.00.00.20.0
Fe content in liver0.30.30.40.7-0.5
K content in liver0.00.00.0-0.2-0.0
Mg content in liver0.20.20.20.5-0.5
Mn content in liver0.20.20.3-0.30.5
Na content in liver0.00.00.00.2-0.1
Rb content in liver0.30.40.70.8-0.2
Se content in liver1.01.11.21.0-1.1
Sr content in liver0.10.10.20.4-0.1
Zn content in liver0.60.70.80.9-0.8
Bone: minimum diameter0.50.91.1-1.00.9
Time in familiar zone, hab. session 10.20.20.30.50.3
Time in novel zone, hab. session 11.01.12.1-1.50.2
Total zone transitions, hab. session 11.11.51.9-1.01.4
Total locomotion distance, hab. session 10.00.00.00.20.0
Locomotion velocity, hab. session 10.00.10.10.30.1
Time in familiar zone, hab. session 20.10.10.20.40.1
Time in novel zone, hab. session 20.30.30.6-0.80.1
Total zone transitions, hab. session 20.10.10.20.4-0.1
Total locomotion distance, hab. session 20.10.10.10.4-0.3
Locomotion velocity, hab. session 20.20.30.40.6-0.4
Novel to familiar place preference ratio1.21.61.7-1.31.2
Novelty place preference0.91.21.2-1.11.1
Time in novel zone, NPP test1.11.41.5-1.21.1
Total zone transitions, NPP test0.10.20.30.6-0.2
Total locomotion distance, NPP test0.81.11.21.1-0.9
Locomotion velocity, NPP test1.01.41.61.3-1.1
Intraocular pressure0.91.41.51.2-1.1
Delta distance traveled before/after self-admin4.34.75.32.3-2.0
Delta ambulatory time before/after self-admin2.84.75.42.3-2.0
Parametrial fat weight1.43.43.51.8-1.9
Pavlov. Cond. lever latency0.60.81.11.1-0.7
Pavlov. Cond. magazine entry latency1.72.23.2-1.81.1
Pavlov. Cond. change in total contacts2.83.03.4-1.81.7
Pavlov. Cond. index score2.63.24.4-2.11.4
Pavlov. Cond. latency score2.12.73.7-1.91.3
Pavlov. Cond. lever contacts0.80.91.3-1.20.7
Pavlov. Cond. magazine entry number1.31.62.31.5-0.9
Pavlov. Cond. intertrial magazine entries1.92.32.71.4-1.6
Pavlov. Cond. lever-magazine prob. diff.2.43.04.2-2.01.3
Pavlov. Cond. response bias0.81.01.5-1.20.8
Pavlov. Cond. lever latency1.62.22.6-1.41.6
Pavlov. Cond. magazine entry latency1.21.72.61.6-0.9
Pavlov. Cond. change in total contacts0.41.01.2-1.10.9
Pavlov. Cond. index score0.81.31.61.3-1.0
Pavlov. Cond. latency score0.71.11.51.2-0.9
Pavlov. Cond. lever contacts1.52.22.31.5-1.5
Pavlov. Cond. magazine entry number0.40.50.7-0.90.4
Pavlov. Cond. intertrial magazine entries0.81.82.21.2-1.5
Pavlov. Cond. lever-magazine prob. diff.0.50.81.11.0-0.8
Pavlov. Cond. response bias1.62.22.21.5-1.5
Time in closed arm before self-admin1.93.43.4-1.81.8
Time in closed arm after self-admin1.41.62.1-1.41.1
Time in open arm before self-admin0.50.60.7-0.80.8
Time in open arm after self-admin0.10.10.10.40.2
Bone: periosteal estimation0.30.60.8-0.90.7
Bone: periosteal perimeter1.22.42.6-1.61.5
Bone: post-yield work0.10.10.2-0.40.1
Progressive ratio test 1 active lever presses1.01.72.51.0-1.6
Progressive ratio test 1 breakpoint1.11.92.71.1-1.6
Progressive ratio test 1 inactive lever presses0.10.20.3-0.2-0.6
Progressive ratio test 2 active lever presses0.10.20.30.1-0.6
Progressive ratio test 2 breakpoint0.10.10.2-0.1-0.4
Progressive ratio test 2 inactive lever presses0.41.21.90.7-1.4
Incentive Sensitization - Responses0.20.60.7-0.80.8
Incentive Sensitization - Breakpoint0.30.70.8-0.90.8
Sum of active levers in priming session hrs 5-60.00.00.1-0.30.0
Progressive ratio0.10.20.40.3-0.6
Food seeking constrained by brief footshock1.21.52.10.9-1.4
Seeking ratio, punishment vs. effort0.00.00.00.1-0.1
Retroperitoneal fat weight2.913.013.83.5-3.7
Reaction time number correct0.00.10.20.50.1
Reaction time mean minus median0.00.10.20.1-0.5
Reaction time mean minus median AUC0.00.00.0-0.2-0.2
Reaction time num false alarms0.10.20.30.20.5
Reaction time num false alarms AUC0.10.10.30.00.5
Reaction time trials correct on left0.00.10.20.50.1
Reaction time trials on left0.00.10.30.50.1
Reaction time mean0.00.10.1-0.2-0.3
Reaction time mean AUC0.00.10.1-0.2-0.3
Median of all reaction times0.00.10.1-0.2-0.3
Reaction time omissions0.40.70.80.7-0.9
Reaction time false alarm rate0.30.40.6-0.50.8
Reaction time premature initiation rate2.03.03.61.6-1.9
Reaction time premature initiations1.03.13.31.7-1.8
Std. dev. reaction times0.00.10.2-0.1-0.4
Reaction time trials completed0.00.10.30.50.1
Reaction time trials AUC0.00.10.10.40.2
Run reversals in cocaine runway, females0.00.00.00.0-0.1
Run reversals in cocaine runway, males2.12.32.6-1.61.4
Latency to leave start box in cocaine runway0.20.30.4-0.40.6
Latency to leave start box in cocaine runway, F0.20.30.3-0.50.5
Latency to leave start box in cocaine runway, M0.20.20.3-0.20.5
Std. dev. time between licks in bursts0.71.31.71.3-1.0
Total sessions with >9 infusions0.40.51.00.1-1.0
Short access day 1 total inactive lever presses0.50.91.20.8-1.1
Short access day 10 total inactive lever presses0.00.00.0-0.1-0.1
Short access day 1 total infusions0.81.62.50.8-1.6
Short access day 10 total infusions0.10.10.2-0.0-0.4
Short access total infusions1.52.13.40.9-1.8
Short access day 1 locomotion0.10.10.2-0.0-0.5
Short access day 10 total locomotion0.00.10.2-0.0-0.4
Short access total locomotion0.40.61.20.1-1.1
One hour access (0.3 mA shock)0.10.10.1-0.3-0.1
Compulsive drug intake0.20.20.4-0.40.6
One hour access (shock baseline)0.00.10.1-0.3-0.1
Social response proportion1.62.02.51.6-1.2
Social responses0.30.40.60.8-0.5
Social time1.01.61.61.3-1.2
Soleus weight0.00.00.0-0.00.1
Bone: stiffness1.73.03.8-1.91.5
Tibialis anterior weight10.937.540.7-6.45.9
Time to tail flick, vehicle, before self-admin0.70.81.50.5-1.2
Time to tail flick, vehicle, after self-admin0.40.91.0-0.91.0
Time to tail flick, test, before self-admin0.20.30.5-0.70.3
Time to tail flick, test, after self-admin0.20.20.3-0.60.1
Delta time to tail flick, vehicle, before/after SA0.30.30.5-0.30.7
Delta time to tail flick, test, before/after SA0.00.00.00.1-0.1
Tibia length0.10.20.40.1-0.6
Ambulatory time before self-admin0.30.91.40.6-1.2
Ambulatory time after self-admin3.04.85.12.1-2.3
Bone: tissue strength0.50.50.9-0.90.3
Total heroin consumption0.70.81.20.6-1.1
Bone: trabecular number0.10.30.30.6-0.5
Bone: trabecular spacing0.20.30.3-0.60.6
Bone: trabecular thickness0.60.91.3-0.71.1
Bone: trabecular tissue density3.25.56.1-2.22.5
Water consumed over 24 hours0.71.31.61.0-1.3
Number of responses in last shaping day1.01.22.1-0.61.4