Hub : Genes

LOC103692984

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg intron excision ratio chr7_134214512_134216407 0.52 0.28 3.5e-03 0.08 0.08 0.08 0.08 3.6e-03 3.4e-03 4.1e-03 3.9e-03
2 RMTg intron excision ratio chr7_134209193_134216407 0.53 0.29 5.9e-03 0.08 0.07 0.03 0.08 4.0e-03 4.9e-03 4.8e-02 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.20.2-0.50.4
Area under the delay curve0.10.10.10.40.0
BMI with tail1.86.37.3-2.32.7
BMI without tail0.92.83.0-1.61.7
Body weight0.73.03.2-1.71.8
Weight adjusted by age1.82.73.1-1.81.5
Bone surface0.20.40.4-0.60.6
Bone volume0.40.80.9-0.90.8
Breakpoint value in progressive ratio session0.00.00.00.10.2
Number of licking bursts0.10.20.2-0.40.4
Context. condit. distance diff. score0.00.00.0-0.0-0.2
Locomotion velocity, session 11.31.42.70.4-1.6
Locomotion distance, session 10.10.10.2-0.3-0.4
Locomotion velocity, session 20.91.11.90.6-1.4
Locomotion distance, session 20.20.30.60.2-0.8
Locomotion velocity, session 32.32.64.11.1-2.0
Locomotion distance, session 33.53.85.21.6-2.3
Stereotopy head waving bouts, day 32.63.03.1-1.71.8
Stereotopy head waving duration, day 30.40.50.6-0.80.6
Locomotion velocity, session 71.61.81.91.4-1.3
Locomotion distance, session 73.44.34.72.0-2.2
Stereotopy head waving bouts, day 75.25.96.0-2.42.4
Stereotopy head waving duration, day 73.54.24.5-2.12.0
Locomotion velocity, session 80.10.10.2-0.4-0.3
Locomotion distance, session 80.71.01.70.6-1.3
Degree of sensitization distance0.30.30.5-0.40.7
Degree of sensitization stereotypy3.23.53.8-1.91.8
Conditioned locomotion0.00.00.0-0.1-0.2
Cocaine response after cond. corrected0.30.40.4-0.60.6
Cocaine response after cond. not corrected0.00.10.1-0.20.2
Cocaine response before conditioning1.51.71.81.3-1.3
Saline control response0.10.20.20.4-0.4
Bone: connectivity density0.10.20.20.4-0.4
Bone: cortical apparent density2.12.93.1-1.61.8
Bone: cortical area0.40.60.8-0.60.9
Bone: cortical porosity0.91.01.40.8-1.2
Bone: cortical porosity1.01.11.50.8-1.2
Bone: cortical thickness0.10.20.4-0.30.6
Bone: cortical thickness0.40.50.60.6-0.8
Bone: cortical tissue density2.02.72.8-1.61.7
Condit. Reinf. active minus inactive responses0.00.00.0-0.1-0.1
Condit. Reinf. active-inactive response ratio0.20.20.30.6-0.4
Condit. Reinf. active responses0.10.10.2-0.2-0.4
Condit. Reinf. inactive responses0.20.30.3-0.5-0.5
Incentive salience index mean0.10.10.1-0.40.2
Condit. Reinf. lever presses0.70.91.0-1.00.9
Condit. Reinf. active minus inactive responses0.60.81.1-0.71.0
Condit. Reinf. active-inactive response ratio0.20.20.3-0.30.5
Condit. Reinf. active responses0.50.70.9-0.71.0
Condit. Reinf. inactive responses0.20.20.3-0.50.4
Condit. Reinf. lever presses0.71.01.21.1-0.9
Condit. Reinf. lever reinforcers received0.10.10.2-0.20.4
Conditioned reinforcement - actives0.30.60.80.9-0.6
Conditioned reinforcement - inactives1.01.52.41.5-0.8
Conditioned locomotion1.01.31.71.3-1.0
Patch foraging indifference point 0 sec0.40.81.01.0-0.7
Patch foraging indifference point AUC0.10.20.3-0.10.6
Delay disc. indifference point, 0s delay0.10.10.30.50.0
Delay disc. indifference point, 16s delay0.30.30.60.7-0.2
Delay disc. indifference point, 2s delay5.76.47.1-2.42.7
Delay disc. indifference point, 24s delay0.00.00.10.2-0.1
Delay disc. indifference point, 4s delay0.10.10.10.30.2
Delay disc. indifference point, 8s delay0.50.60.70.9-0.7
Indifference point function ln k0.40.61.2-1.10.2
Indifference point function log k0.40.61.2-1.10.2
Patch foraging total patch changes 0 sec0.61.21.31.1-1.1
Patch foraging total patch changes 12 sec0.40.61.11.0-0.3
Patch foraging total patch changes 18 sec0.50.81.11.0-0.7
Patch foraging total patch changes 24 sec0.40.71.11.0-0.5
Patch foraging total patch changes 6 sec0.60.91.61.3-0.4
Patch foraging time to switch 0 sec0.10.20.2-0.30.5
Patch foraging water rate 0 sec0.00.00.1-0.30.1
Patch foraging water rate 12 sec0.10.30.4-0.4-0.6
Patch foraging water rate 18 sec0.00.00.0-0.20.1
Patch foraging water rate 24 sec0.30.50.5-0.70.7
Patch foraging water rate 6 sec0.10.10.2-0.3-0.4
Seeking ratio, delayed vs. immediate footshock0.00.00.00.2-0.2
Distance traveled before self-admin0.70.91.61.3-0.5
Distance traveled after self-admin4.55.67.02.6-2.0
Extensor digitorum longus weight7.931.132.6-5.45.7
Bone: elastic displacement3.33.84.51.8-2.1
Bone: elastic work2.43.13.11.8-1.8
Bone: endosteal estimation0.10.20.3-0.40.5
Bone: endosteal perimeter0.61.21.3-1.01.1
Epididymis fat weight2.17.37.42.7-2.7
Delta time in closed arm before/after self-admin0.50.50.80.9-0.4
Delta time in open arm before/after self-admin2.22.12.51.3-1.6
Diff in mean of infusions in LGA sessions1.11.31.6-1.31.0
Delay discount exponential model param0.00.00.1-0.2-0.2
Extinction: sum of active levers before priming1.21.31.4-1.11.2
Active lever presses in extinction session 61.21.21.91.4-0.7
Bone: final force0.10.10.20.00.4
Bone: final moment0.00.10.10.10.4
Food consumed during 24 hour testing period0.60.80.90.8-0.9
Glucose0.10.20.40.1-0.6
Heart weight0.50.81.21.1-0.6
Delay discount hyperbolic model param0.10.10.2-0.1-0.4
Intermittent access intake day 1-15 change0.51.01.31.1-0.8
Intermittent access intake escalation0.10.30.50.7-0.3
Intermittent access intake escalation 21.01.11.61.3-0.8
Intermitt. access day 1 inactive lever presses0.10.30.30.50.6
Intermitt. access day 15 inactive lever presses0.00.10.10.30.0
Intermitt. access escalation Index0.81.11.3-1.01.1
Intermittent access day 1 total infusions0.20.40.70.8-0.3
Intermittent access day 15 total infusions0.10.10.20.50.0
Intermittent access terminal intake (last 3 days)0.10.20.30.6-0.2
Intermittent access total infusions0.30.30.70.8-0.1
Intermittent access day 1 locomotion1.01.22.11.4-0.6
Intermittent access day 15 total locomotion2.64.76.02.4-1.8
Intermittent access total locomotion2.42.94.22.1-1.3
Intermittent access standard deviation2.04.26.72.6-1.3
Left kidney weight0.00.20.3-0.10.6
Right kidney weight0.21.01.1-1.01.0
Cocaine induced anxiety0.20.20.5-0.7-0.0
Post-drug Anxiety0.20.20.3-0.1-0.6
Baseline Anxiety0.00.00.1-0.30.1
Tail length0.10.30.60.1-0.8
Length with tail0.00.10.3-0.5-0.1
Length without tail0.00.10.2-0.40.3
Times rat made contact with spout0.60.70.90.6-1.0
Lifetime Intake1.11.32.31.5-0.5
Liver weight, left0.00.00.0-0.00.1
Liver weight, right0.10.20.40.6-0.2
Locomotor activity0.40.70.90.9-0.7
Locomotor testing distance0.71.21.41.2-1.0
Locomotor testing rearing0.81.62.21.5-1.1
Locomotion in novel chamber0.60.81.1-0.71.0
Locomotion in novel chamber post-restriction1.42.34.12.0-0.7
Fecal boli incidents, locomotor time 12.33.33.61.8-1.9
Change in fecal boli incidents, locomotor task1.91.92.4-1.51.1
Time >=10cm from walls, locomotor time 10.20.20.3-0.4-0.6
Bouts of movement, locomotor time 10.10.10.20.3-0.4
Total resting periods, locomotor time 10.20.30.40.3-0.7
Rest time, locomotor task time 10.40.40.70.4-0.8
Distance moved, locomotor task time 10.20.40.70.00.8
Vertical activity count, locomotor time 10.61.32.1-0.71.5
Time >=10cm from walls, locomotor time 20.30.40.50.6-0.7
Bouts of movement, locomotor time 20.71.21.6-0.91.3
Total resting periods, locomotor time 21.01.82.3-1.21.5
Rest time, locomotor task time 20.20.30.5-0.70.2
Distance moved, locomotor task time 20.10.10.10.20.3
Vertical activity count, locomotor time 20.10.10.10.30.3
Light reinforcement 10.10.20.30.6-0.1
Light reinforcement 20.10.10.1-0.30.3
Bone: marrow area0.10.20.2-0.30.5
Bone: maximum diameter0.30.60.6-0.80.8
Bone: maximum force0.50.91.2-0.81.1
Bone: maximum moment0.40.60.9-0.60.9
Mean time between licks in bursts0.61.41.81.0-1.3
Mean num. licks in bursts0.91.41.61.1-1.3
Cd content in liver0.10.10.20.0-0.4
Co content in liver0.20.20.3-0.50.3
Cu content in liver0.00.00.10.2-0.1
Fe content in liver0.50.60.70.9-0.7
K content in liver0.00.00.0-0.00.2
Mg content in liver0.20.20.20.3-0.5
Mn content in liver0.20.20.3-0.60.3
Na content in liver0.10.10.10.3-0.2
Rb content in liver0.60.70.70.8-0.8
Se content in liver1.01.21.21.1-1.0
Sr content in liver0.20.20.20.3-0.4
Zn content in liver0.50.60.80.6-0.9
Bone: minimum diameter0.50.91.1-0.91.0
Time in familiar zone, hab. session 10.10.10.3-0.0-0.5
Time in novel zone, hab. session 11.41.42.1-0.81.5
Total zone transitions, hab. session 11.21.72.2-1.51.0
Total locomotion distance, hab. session 10.00.10.1-0.3-0.2
Locomotion velocity, hab. session 10.10.10.1-0.2-0.3
Time in familiar zone, hab. session 20.10.10.20.1-0.4
Time in novel zone, hab. session 20.40.40.6-0.50.8
Total zone transitions, hab. session 20.10.10.20.0-0.4
Total locomotion distance, hab. session 20.10.10.10.1-0.4
Locomotion velocity, hab. session 20.20.20.40.3-0.6
Novel to familiar place preference ratio1.82.02.3-1.51.3
Novelty place preference1.51.62.0-1.41.1
Time in novel zone, NPP test1.71.82.2-1.51.2
Total zone transitions, NPP test0.10.20.30.1-0.6
Total locomotion distance, NPP test0.71.01.20.9-1.1
Locomotion velocity, NPP test1.01.41.61.1-1.3
Intraocular pressure1.21.71.81.4-1.2
Delta distance traveled before/after self-admin4.64.95.32.1-2.3
Delta ambulatory time before/after self-admin4.25.15.42.2-2.3
Parametrial fat weight1.33.13.31.7-1.8
Pavlov. Cond. lever latency0.81.01.10.9-1.1
Pavlov. Cond. magazine entry latency2.12.63.2-1.41.8
Pavlov. Cond. change in total contacts3.13.23.4-1.81.8
Pavlov. Cond. index score2.83.64.4-1.72.1
Pavlov. Cond. latency score2.43.03.7-1.51.9
Pavlov. Cond. lever contacts0.91.11.3-0.91.2
Pavlov. Cond. magazine entry number1.51.82.31.2-1.5
Pavlov. Cond. intertrial magazine entries1.61.91.91.4-1.4
Pavlov. Cond. lever-magazine prob. diff.2.73.44.2-1.62.1
Pavlov. Cond. response bias1.01.21.5-1.01.2
Pavlov. Cond. lever latency1.21.71.9-1.21.4
Pavlov. Cond. magazine entry latency1.92.32.61.4-1.6
Pavlov. Cond. change in total contacts0.91.41.5-1.21.1
Pavlov. Cond. index score0.91.31.61.0-1.3
Pavlov. Cond. latency score0.91.21.50.9-1.2
Pavlov. Cond. lever contacts1.31.82.31.1-1.5
Pavlov. Cond. magazine entry number0.60.70.7-0.80.9
Pavlov. Cond. intertrial magazine entries0.91.41.41.2-1.2
Pavlov. Cond. lever-magazine prob. diff.0.60.81.10.8-1.0
Pavlov. Cond. response bias1.42.02.11.3-1.5
Time in closed arm before self-admin2.73.53.5-1.91.8
Time in closed arm after self-admin1.31.42.1-0.91.4
Time in open arm before self-admin0.50.60.7-0.70.8
Time in open arm after self-admin0.10.10.1-0.2-0.4
Bone: periosteal estimation0.30.60.8-0.70.9
Bone: periosteal perimeter1.42.42.6-1.51.6
Bone: post-yield work0.10.10.2-0.20.4
Progressive ratio test 1 active lever presses1.62.02.91.7-1.0
Progressive ratio test 1 breakpoint1.72.13.01.7-1.1
Progressive ratio test 1 inactive lever presses0.40.61.11.10.2
Progressive ratio test 2 active lever presses0.20.30.50.7-0.1
Progressive ratio test 2 breakpoint0.10.10.30.50.1
Progressive ratio test 2 inactive lever presses0.91.42.31.5-0.7
Incentive Sensitization - Responses0.50.70.8-0.90.8
Incentive Sensitization - Breakpoint0.60.80.8-0.80.9
Sum of active levers in priming session hrs 5-60.00.00.10.10.3
Progressive ratio0.20.40.70.8-0.3
Food seeking constrained by brief footshock1.72.13.31.8-0.9
Seeking ratio, punishment vs. effort0.00.00.00.2-0.1
Retroperitoneal fat weight3.012.613.13.6-3.5
Reaction time number correct0.20.30.5-0.7-0.5
Reaction time mean minus median0.30.91.71.3-0.1
Reaction time mean minus median AUC0.20.40.90.90.2
Reaction time num false alarms0.10.10.2-0.5-0.2
Reaction time num false alarms AUC0.10.10.2-0.5-0.0
Reaction time trials correct on left0.20.30.5-0.7-0.5
Reaction time trials on left0.20.30.4-0.6-0.5
Reaction time mean0.30.40.80.90.2
Reaction time mean AUC0.20.40.70.90.2
Median of all reaction times0.10.20.40.60.2
Reaction time omissions0.81.21.91.4-0.7
Reaction time false alarm rate0.20.20.2-0.40.5
Reaction time premature initiation rate2.23.03.51.9-1.6
Reaction time premature initiations1.52.63.01.5-1.7
Std. dev. reaction times0.40.81.51.20.1
Reaction time trials completed0.20.30.4-0.6-0.5
Reaction time trials AUC0.20.40.7-0.8-0.4
Run reversals in cocaine runway, females0.00.00.00.1-0.0
Run reversals in cocaine runway, males2.32.32.6-1.41.6
Latency to leave start box in cocaine runway0.20.30.4-0.60.4
Latency to leave start box in cocaine runway, F0.20.30.3-0.50.5
Latency to leave start box in cocaine runway, M0.20.20.3-0.50.2
Std. dev. time between licks in bursts0.91.31.70.9-1.3
Total sessions with >9 infusions0.80.91.91.4-0.1
Short access day 1 total inactive lever presses0.81.11.61.3-0.8
Short access day 10 total inactive lever presses0.00.00.00.10.1
Short access day 1 total infusions1.52.03.31.8-0.8
Short access day 10 total infusions0.20.20.50.70.0
Short access total infusions2.22.94.82.2-0.9
Short access day 1 locomotion0.20.30.60.8-0.0
Short access day 10 total locomotion0.10.30.50.70.0
Short access total locomotion1.01.22.31.5-0.1
One hour access (0.3 mA shock)0.10.10.10.40.3
Compulsive drug intake0.20.20.3-0.50.4
One hour access (shock baseline)0.10.10.10.40.3
Social response proportion2.62.93.31.8-1.6
Social responses0.40.60.60.8-0.7
Social time1.31.82.01.4-1.3
Soleus weight0.00.00.0-0.10.0
Bone: stiffness2.03.23.8-1.61.9
Tibialis anterior weight11.539.140.7-6.16.4
Time to tail flick, vehicle, before self-admin1.61.63.11.8-0.5
Time to tail flick, vehicle, after self-admin1.11.52.2-1.50.8
Time to tail flick, test, before self-admin0.30.30.5-0.30.7
Time to tail flick, test, after self-admin0.20.20.3-0.00.6
Delta time to tail flick, vehicle, before/after SA1.00.91.7-1.30.3
Delta time to tail flick, test, before/after SA0.10.10.10.3-0.1
Tibia length0.00.10.10.4-0.1
Ambulatory time before self-admin0.91.32.31.5-0.6
Ambulatory time after self-admin5.36.38.12.8-2.1
Bone: tissue strength0.50.50.9-0.40.9
Total heroin consumption0.80.91.51.2-0.6
Bone: trabecular number0.20.30.30.5-0.6
Bone: trabecular spacing0.20.30.3-0.50.6
Bone: trabecular thickness0.70.91.4-1.20.7
Bone: trabecular tissue density3.95.86.6-2.62.2
Water consumed over 24 hours0.81.11.21.1-1.0
Number of responses in last shaping day1.51.73.0-1.70.6