Hub : Genes

Pygo1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr8_73700709_73703207	0.03	0.02	7.2e-03	0.01	0.01	0.01	0.01	2.6e-02	2.0e-02	4.6e-02	2.2e-02
2	Adipose	gene expression	Pygo1	0.02	0.02	2.4e-03	0.01	0.02	0.02	0.01	1.5e-02	3.1e-03	5.0e-03	8.5e-03
3	PL	gene expression	Pygo1	0.06	0.03	2.3e-05	0.04	0.03	0.03	0.04	2.9e-05	2.7e-04	1.2e-04	5.6e-05
4	Brain	gene expression	Pygo1	0.2	0.1	1.5e-14	0.15	0.16	0.16	0.16	7.8e-14	5.8e-15	8.2e-15	1.1e-14
5	BLA	gene expression	Pygo1	0.13	0.07	1.3e-04	0.03	0.04	0.05	0.04	8.2e-03	5.6e-03	1.6e-03	2.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.1	0.3	0.1	0.2	0.6	0.0	0.1
Area under the delay curve	1.6	1.7	3.2	-0.8	-0.9	1.2	-1.5	1.8
BMI with tail	6.7	21.7	31.6	-5.3	-5.6	4.0	-4.4	3.6
BMI without tail	0.6	1.2	3.8	-1.5	-1.9	-0.2	-0.1	-0.4
Body weight	4.3	17.9	22.3	-4.7	-4.7	4.3	-4.0	3.3
Weight adjusted by age	1.8	2.0	4.5	-2.0	-2.1	0.6	-1.0	0.2
Bone surface	0.2	0.3	0.6	-0.6	-0.6	0.7	-0.2	0.1
Bone volume	0.4	0.7	1.3	-0.9	-0.7	1.2	-0.6	0.5
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.0	0.2
Number of licking bursts	3.0	3.5	4.4	2.1	2.0	-2.0	1.7	-1.5
Context. condit. distance diff. score	0.2	0.2	0.5	-0.2	-0.1	0.5	-0.6	0.7
Locomotion velocity, session 1	0.2	0.3	0.4	-0.6	-0.6	-0.4	0.2	-0.6
Locomotion distance, session 1	0.4	0.6	1.0	0.8	0.6	-1.0	0.7	-0.7
Locomotion velocity, session 2	0.1	0.1	0.2	0.0	-0.1	-0.1	0.5	-0.3
Locomotion distance, session 2	0.2	0.2	0.4	0.0	-0.4	-0.6	0.6	-0.5
Locomotion velocity, session 3	2.0	2.3	4.0	0.9	0.7	-1.6	1.9	-2.0
Locomotion distance, session 3	2.6	2.8	4.0	2.0	1.7	-1.7	1.6	-1.2
Stereotopy head waving bouts, day 3	0.2	0.3	0.6	-0.8	-0.6	0.4	-0.5	0.1
Stereotopy head waving duration, day 3	0.6	0.7	1.5	-1.2	-1.0	0.8	-0.7	0.2
Locomotion velocity, session 7	0.5	0.6	1.0	1.0	0.9	-0.7	0.6	-0.4
Locomotion distance, session 7	1.8	2.3	2.7	1.6	1.4	-1.6	1.6	-1.3
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	-0.5	-0.6	-0.3	0.2	-0.5
Stereotopy head waving duration, day 7	0.3	0.3	0.8	-0.5	-0.5	-0.3	0.5	-0.9
Locomotion velocity, session 8	0.4	0.5	1.5	-0.1	-0.0	-0.4	1.0	-1.2
Locomotion distance, session 8	0.4	0.6	0.9	0.8	0.5	-1.0	1.0	-0.7
Degree of sensitization distance	0.1	0.1	0.1	0.2	0.2	-0.2	0.3	-0.3
Degree of sensitization stereotypy	0.2	0.2	0.6	-0.6	-0.8	-0.1	0.0	-0.2
Conditioned locomotion	2.8	3.3	5.2	-1.3	-1.4	2.0	-1.9	2.3
Cocaine response after cond. corrected	2.9	3.2	6.0	-2.5	-2.1	1.6	-1.6	0.7
Cocaine response after cond. not corrected	2.4	2.7	4.6	-2.2	-1.8	1.5	-1.6	0.8
Cocaine response before conditioning	0.2	0.3	0.7	0.8	0.7	-0.2	0.0	0.4
Saline control response	0.3	0.4	0.8	0.3	0.5	-0.7	0.7	-0.9
Bone: connectivity density	1.8	2.9	3.8	1.8	1.8	-1.3	2.0	-1.6
Bone: cortical apparent density	0.2	0.3	0.6	0.7	0.8	-0.5	0.2	-0.1
Bone: cortical area	2.5	3.7	5.0	-1.8	-1.4	2.2	-2.2	1.9
Bone: cortical porosity	0.3	0.3	0.6	0.2	0.3	0.8	-0.4	0.7
Bone: cortical porosity	0.3	0.3	0.6	0.5	0.7	0.8	-0.2	0.6
Bone: cortical thickness	0.6	1.0	1.9	-0.2	0.1	1.2	-1.3	1.4
Bone: cortical thickness	0.1	0.2	0.3	0.1	0.4	0.6	-0.5	0.4
Bone: cortical tissue density	0.3	0.4	0.7	0.8	0.8	-0.6	0.3	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.9	0.3	0.0	0.4	-0.3	0.9
Condit. Reinf. active-inactive response ratio	1.1	1.2	2.6	-0.1	-0.0	1.4	-1.3	1.6
Condit. Reinf. active responses	0.2	0.3	0.6	0.6	0.1	-0.5	0.8	-0.3
Condit. Reinf. inactive responses	2.8	3.3	5.5	1.0	0.5	-2.2	2.4	-2.3
Incentive salience index mean	0.6	0.7	1.9	-0.1	-0.4	0.9	-0.8	1.4
Condit. Reinf. lever presses	0.4	0.6	1.5	-0.2	-0.5	0.7	-0.7	1.2
Condit. Reinf. active minus inactive responses	1.4	1.8	3.1	-1.8	-1.6	1.5	-0.8	0.4
Condit. Reinf. active-inactive response ratio	2.2	2.3	3.3	-1.8	-1.6	1.7	-1.4	1.0
Condit. Reinf. active responses	1.3	1.8	2.5	-1.6	-1.5	1.5	-1.0	0.9
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.5	0.3	-0.2	0.5	-0.1
Condit. Reinf. lever presses	0.2	0.3	0.8	-0.0	0.3	0.9	-0.6	0.7
Condit. Reinf. lever reinforcers received	1.4	1.9	2.7	-1.5	-1.4	1.7	-1.2	1.1
Conditioned reinforcement - actives	0.2	0.2	0.4	0.2	0.2	-0.6	0.5	-0.6
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.1	-0.0	-0.2	0.1	-0.3
Conditioned locomotion	0.6	0.7	1.5	-0.2	-0.2	1.2	-0.9	1.2
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.1	-0.1	-0.3	0.1	-0.3
Patch foraging indifference point AUC	0.9	1.0	1.6	1.3	0.8	-1.0	1.2	-0.6
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	0.8	0.5	-0.4	0.3	0.2
Delay disc. indifference point, 16s delay	1.6	1.7	3.4	-0.7	-0.5	1.3	-1.6	1.8
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	0.3	0.3	-0.3	0.1	-0.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.1	-0.0	0.4	-0.4	0.5
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	-0.1	-0.1	0.8	-0.7	1.1
Delay disc. indifference point, 8s delay	1.0	1.0	1.4	-0.9	-1.2	0.7	-1.1	1.2
Indifference point function ln k	0.9	1.3	2.2	-1.5	-1.1	0.9	-1.4	0.6
Indifference point function log k	0.9	1.3	2.2	-1.5	-1.1	0.9	-1.4	0.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.3	-0.3	-0.2	-0.1	-0.2
Patch foraging total patch changes 12 sec	0.4	0.5	0.9	0.8	0.6	-0.5	0.9	-0.5
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.3	0.1	-0.3	0.1	0.1
Patch foraging total patch changes 24 sec	1.1	1.3	2.1	1.0	0.7	-1.4	1.3	-1.1
Patch foraging total patch changes 6 sec	0.3	0.4	0.8	0.5	0.0	-0.9	0.8	-0.5
Patch foraging time to switch 0 sec	0.2	0.3	0.9	0.7	0.9	0.3	0.4	-0.2
Patch foraging water rate 0 sec	0.9	1.5	2.7	-1.6	-1.7	0.5	-1.2	0.7
Patch foraging water rate 12 sec	0.7	1.1	2.6	-1.6	-1.6	-0.1	-0.3	-0.6
Patch foraging water rate 18 sec	0.1	0.2	0.4	-0.6	-0.6	0.1	-0.3	-0.0
Patch foraging water rate 24 sec	0.9	1.2	2.0	0.9	0.8	-1.4	1.2	-1.2
Patch foraging water rate 6 sec	0.1	0.1	0.3	-0.3	-0.4	-0.5	0.0	-0.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.4	-1.0	-1.2	0.2	-0.4	0.1
Distance traveled before self-admin	0.1	0.1	0.2	-0.2	-0.1	0.5	-0.3	0.3
Distance traveled after self-admin	0.9	1.0	1.9	-1.4	-1.1	0.8	-1.0	0.4
Extensor digitorum longus weight	4.4	17.2	30.3	-5.4	-5.5	3.7	-3.0	1.9
Bone: elastic displacement	0.1	0.1	0.2	-0.3	-0.4	0.3	-0.4	0.4
Bone: elastic work	0.6	0.8	1.6	-0.5	-0.4	1.2	-1.0	1.0
Bone: endosteal estimation	1.6	3.5	5.9	-2.4	-2.4	1.6	-1.6	1.0
Bone: endosteal perimeter	3.6	7.6	10.9	-3.3	-3.2	2.8	-2.4	1.8
Epididymis fat weight	0.7	1.6	2.8	1.0	0.9	-1.0	1.7	-1.5
Delta time in closed arm before/after self-admin	0.6	0.6	1.1	-0.6	-0.5	0.7	-1.1	0.9
Delta time in open arm before/after self-admin	4.0	3.9	4.8	1.8	1.9	-1.7	2.2	-2.1
Diff in mean of infusions in LGA sessions	1.3	1.4	1.6	-1.1	-1.3	1.2	-1.2	1.1
Delay discount exponential model param	1.3	1.4	2.6	0.8	0.9	-1.1	1.4	-1.6
Extinction: sum of active levers before priming	1.5	1.5	1.7	1.2	1.3	-1.2	1.2	-1.2
Active lever presses in extinction session 6	0.3	0.3	0.5	0.4	0.4	-0.4	0.7	-0.7
Bone: final force	2.1	3.4	5.0	-1.9	-1.7	2.2	-1.8	1.5
Bone: final moment	2.2	3.6	5.5	-1.9	-1.5	2.4	-2.0	1.7
Food consumed during 24 hour testing period	0.3	0.3	0.7	-0.8	-0.6	0.2	-0.7	0.2
Glucose	0.1	0.1	0.2	-0.5	-0.5	-0.2	-0.1	-0.4
Heart weight	1.3	1.8	2.3	-1.3	-1.4	1.5	-1.2	1.2
Delay discount hyperbolic model param	0.9	1.0	1.9	0.6	0.6	-0.9	1.1	-1.4
Intermittent access intake day 1-15 change	2.7	2.7	4.1	1.0	1.0	-2.0	1.8	-2.0
Intermittent access intake escalation	3.1	3.0	4.4	1.2	1.2	-2.1	1.9	-2.1
Intermittent access intake escalation 2	0.3	0.3	0.7	0.2	0.1	-0.8	0.5	-0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	0.1	0.4	-0.1	-0.5	0.2
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.8	-0.3	-0.2	0.8	-0.7	0.9
Intermitt. access escalation Index	2.1	1.8	2.1	-1.2	-1.3	1.4	-1.4	1.4
Intermittent access day 1 total infusions	0.2	0.2	0.7	0.5	0.9	-0.1	0.1	-0.3
Intermittent access day 15 total infusions	1.7	1.9	2.2	1.2	1.5	-1.4	1.4	-1.5
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.7	0.6	0.8	-0.4	0.3	-0.4
Intermittent access total infusions	1.3	1.5	1.9	1.0	1.4	-1.1	1.1	-1.4
Intermittent access day 1 locomotion	0.8	0.8	1.9	1.1	1.4	-0.6	0.6	-0.6
Intermittent access day 15 total locomotion	0.2	0.2	0.7	0.4	0.8	0.3	-0.1	0.2
Intermittent access total locomotion	0.2	0.2	0.3	0.3	0.6	-0.3	0.3	-0.5
Intermittent access standard deviation	0.8	0.8	1.1	0.9	1.0	-1.0	0.8	-0.8
Left kidney weight	2.0	5.6	8.6	-2.9	-2.7	2.4	-2.2	1.3
Right kidney weight	1.1	3.0	4.6	-2.2	-2.1	1.9	-1.4	0.9
Cocaine induced anxiety	0.1	0.1	0.2	0.4	0.1	-0.0	0.2	0.3
Post-drug Anxiety	2.2	2.4	3.5	1.9	1.5	-1.4	1.8	-1.1
Baseline Anxiety	2.1	2.2	2.7	1.4	1.4	-1.4	1.6	-1.5
Tail length	1.7	5.2	7.3	1.8	1.7	-2.4	2.6	-2.7
Length with tail	0.1	0.5	1.2	-0.8	-0.5	1.1	-0.5	0.2
Length without tail	6.4	13.9	19.3	-3.5	-3.0	4.4	-4.0	3.6
Times rat made contact with spout	0.0	0.0	0.1	0.1	0.1	-0.0	-0.3	0.3
Lifetime Intake	1.3	1.5	1.9	1.1	1.4	-1.0	1.1	-1.4
Liver weight, left	0.2	0.3	0.6	-0.5	-0.6	-0.8	0.2	-0.8
Liver weight, right	0.4	0.7	1.6	-1.2	-1.3	-0.1	0.0	-0.6
Locomotor activity	3.9	6.1	9.2	-3.0	-2.8	2.4	-2.3	1.5
Locomotor testing distance	2.1	3.5	5.5	-2.3	-2.2	1.6	-1.8	1.1
Locomotor testing rearing	0.2	0.4	0.9	-0.9	-0.9	0.4	-0.3	0.0
Locomotion in novel chamber	0.2	0.2	0.6	0.4	0.7	0.1	-0.3	0.3
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.2	0.2	0.2	-0.1	0.3
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	0.1	-0.1	0.4	-0.4	0.8
Change in fecal boli incidents, locomotor task	0.7	0.7	1.5	-1.2	-0.8	0.4	-1.0	0.3
Time >=10cm from walls, locomotor time 1	1.6	1.6	2.0	-1.2	-1.3	1.0	-1.4	1.3
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.3	-0.5	0.2	-0.4	0.5
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.1	-0.3	0.1	-0.4	0.4
Rest time, locomotor task time 1	0.4	0.5	1.1	-0.1	-0.1	0.6	-1.0	1.1
Distance moved, locomotor task time 1	1.0	1.1	1.8	0.7	0.6	-1.1	1.4	-1.3
Vertical activity count, locomotor time 1	0.2	0.2	0.4	0.4	0.3	-0.3	0.6	-0.5
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.0	-0.5	-0.6	0.4	-1.0	1.0
Bouts of movement, locomotor time 2	0.2	0.2	0.6	-0.4	-0.8	-0.5	0.1	-0.1
Total resting periods, locomotor time 2	0.2	0.2	0.6	-0.4	-0.8	-0.6	0.1	-0.2
Rest time, locomotor task time 2	0.1	0.2	0.3	0.2	0.3	0.0	-0.6	0.6
Distance moved, locomotor task time 2	1.2	1.4	2.8	0.6	0.5	-1.1	1.6	-1.7
Vertical activity count, locomotor time 2	2.0	2.2	2.8	1.4	1.4	-1.3	1.7	-1.6
Light reinforcement 1	2.6	4.6	6.6	-2.3	-2.6	1.7	-2.1	2.0
Light reinforcement 2	0.3	0.4	1.0	0.1	0.4	0.5	-1.0	0.9
Bone: marrow area	1.8	3.9	6.4	-2.5	-2.4	1.7	-1.8	1.1
Bone: maximum diameter	3.5	6.4	8.6	-2.9	-2.7	2.4	-2.6	2.0
Bone: maximum force	2.2	3.8	6.1	-2.0	-1.8	2.5	-1.8	1.5
Bone: maximum moment	2.3	4.0	6.6	-2.0	-1.7	2.6	-2.0	1.7
Mean time between licks in bursts	0.5	0.7	1.5	1.1	1.2	-0.3	0.6	-0.5
Mean num. licks in bursts	3.0	3.6	4.1	-2.0	-1.9	2.0	-1.9	1.6
Cd content in liver	0.0	0.1	0.2	0.3	0.0	-0.2	0.4	-0.0
Co content in liver	1.2	1.4	3.1	-0.5	-0.7	1.2	-1.3	1.8
Cu content in liver	0.9	1.1	1.7	-1.1	-1.0	1.3	-1.0	0.9
Fe content in liver	2.7	3.3	4.3	1.6	1.5	-2.0	2.1	-1.9
K content in liver	0.9	0.9	1.5	-1.2	-1.0	1.2	-0.6	0.4
Mg content in liver	2.6	2.7	3.9	-2.0	-1.9	1.7	-1.4	1.0
Mn content in liver	2.2	2.5	3.6	-1.4	-1.0	1.9	-1.9	1.6
Na content in liver	0.5	0.5	1.1	-1.0	-1.1	0.5	-0.5	0.1
Rb content in liver	0.5	0.6	1.2	-1.0	-1.1	0.2	0.3	-0.7
Se content in liver	0.9	1.0	1.4	0.9	1.1	-0.7	1.2	-1.1
Sr content in liver	0.2	0.2	0.4	0.7	0.5	-0.2	0.4	-0.0
Zn content in liver	1.2	1.3	2.6	-0.5	-0.4	1.4	-1.3	1.6
Bone: minimum diameter	2.6	4.8	6.9	-1.7	-1.5	2.6	-2.4	2.4
Time in familiar zone, hab. session 1	0.8	0.8	1.6	-0.5	-0.6	0.9	-1.0	1.3
Time in novel zone, hab. session 1	0.6	0.6	1.0	0.5	0.7	-0.7	0.8	-1.0
Total zone transitions, hab. session 1	1.1	1.6	2.6	1.2	0.8	-1.6	1.4	-1.2
Total locomotion distance, hab. session 1	0.7	1.0	1.8	0.8	0.5	-1.3	1.2	-1.1
Locomotion velocity, hab. session 1	0.5	0.7	1.4	0.5	0.2	-1.2	0.9	-0.9
Time in familiar zone, hab. session 2	0.6	0.6	0.8	0.6	0.6	-0.9	0.8	-0.8
Time in novel zone, hab. session 2	0.8	0.8	1.1	-0.7	-0.6	0.9	-1.1	0.9
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.2	-0.3	-0.4	0.4	-0.1
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.2	-0.7	-0.0	0.0	0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.4	-0.2	-0.6	0.1	-0.1	0.4
Novel to familiar place preference ratio	1.5	1.5	1.9	-1.4	-1.4	1.2	-1.1	1.0
Novelty place preference	1.9	1.9	2.4	-1.5	-1.5	1.4	-1.3	1.2
Time in novel zone, NPP test	2.1	2.1	2.8	-1.7	-1.6	1.4	-1.4	1.2
Total zone transitions, NPP test	0.1	0.1	0.3	0.1	-0.4	-0.5	0.2	0.0
Total locomotion distance, NPP test	0.2	0.3	0.8	0.1	-0.3	-0.9	0.6	-0.6
Locomotion velocity, NPP test	0.6	0.9	1.7	0.6	0.1	-1.3	1.1	-0.9
Intraocular pressure	0.1	0.1	0.3	0.2	0.2	-0.5	0.5	-0.4
Delta distance traveled before/after self-admin	0.8	0.9	2.1	-1.5	-1.2	0.4	-0.8	0.1
Delta ambulatory time before/after self-admin	0.7	0.8	1.7	-1.3	-0.9	0.6	-0.9	0.2
Parametrial fat weight	1.3	2.6	3.0	1.6	1.5	-1.6	1.7	-1.7
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.2	0.3	-0.3	-0.0	-0.4
Pavlov. Cond. magazine entry latency	1.5	1.9	5.0	0.3	0.0	1.8	-1.1	2.2
Pavlov. Cond. change in total contacts	0.7	0.7	1.8	-0.1	-0.4	1.1	-0.7	1.4
Pavlov. Cond. index score	0.4	0.5	1.0	0.8	0.4	0.6	-0.0	1.0
Pavlov. Cond. latency score	0.2	0.3	0.6	0.8	0.4	0.4	0.1	0.7
Pavlov. Cond. lever contacts	0.2	0.2	0.6	0.2	-0.1	0.6	-0.2	0.8
Pavlov. Cond. magazine entry number	1.0	1.2	3.2	-0.6	-0.3	-1.4	0.7	-1.8
Pavlov. Cond. intertrial magazine entries	2.2	2.6	4.5	0.8	0.6	-2.0	1.9	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.2	0.7	0.3	0.7	-0.1	1.1
Pavlov. Cond. response bias	1.1	1.3	3.4	0.2	-0.1	1.5	-0.9	1.9
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.4	-0.3	-0.6	0.3	-0.7
Pavlov. Cond. magazine entry latency	1.8	2.1	4.3	2.1	2.0	-1.2	0.9	-0.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	0.8	0.8	-0.0	0.3	0.1
Pavlov. Cond. index score	0.5	0.6	1.4	1.2	1.1	-0.3	0.5	0.1
Pavlov. Cond. latency score	0.3	0.4	0.9	1.0	0.9	-0.2	0.3	0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.6	0.3	0.2	0.5	-0.4	0.8
Pavlov. Cond. magazine entry number	1.8	2.2	4.0	-2.0	-1.9	1.2	-1.2	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	-0.7	-0.5	-0.0	0.1	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.7	1.3	1.2	-0.3	0.5	0.1
Pavlov. Cond. response bias	0.3	0.4	0.9	1.0	0.8	0.3	0.0	0.7
Time in closed arm before self-admin	0.1	0.1	0.3	-0.0	-0.1	0.6	-0.3	0.6
Time in closed arm after self-admin	0.1	0.1	0.2	-0.3	-0.3	0.4	-0.4	0.4
Time in open arm before self-admin	1.1	1.2	1.8	-1.3	-1.2	0.9	-1.1	0.7
Time in open arm after self-admin	0.4	0.4	0.8	0.4	0.6	-0.5	0.6	-0.9
Bone: periosteal estimation	2.6	5.4	7.2	-2.7	-2.5	2.2	-2.3	1.7
Bone: periosteal perimeter	2.6	4.4	6.5	-2.6	-2.3	2.2	-1.9	1.3
Bone: post-yield work	0.1	0.1	0.2	-0.4	-0.4	0.3	0.1	-0.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	0.0	0.2	-0.5	0.4	-0.8
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	0.2	0.4	-0.4	0.3	-0.6
Progressive ratio test 1 inactive lever presses	2.6	2.8	3.9	1.3	1.7	-1.8	1.5	-2.0
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.6	-0.5	0.2	-0.1	-0.1
Progressive ratio test 2 breakpoint	0.1	0.2	0.4	-0.7	-0.5	0.2	-0.1	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.4	0.3	0.6	0.2	0.1	-0.1
Incentive Sensitization - Responses	2.0	2.0	2.5	-1.6	-1.6	1.5	-1.3	1.1
Incentive Sensitization - Breakpoint	1.7	1.7	2.1	-1.4	-1.5	1.4	-1.2	1.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.0	-0.1
Progressive ratio	0.9	1.1	2.9	-0.1	-0.3	1.2	-1.1	1.7
Food seeking constrained by brief footshock	0.4	0.5	0.9	-0.1	-0.3	-0.9	0.7	-0.9
Seeking ratio, punishment vs. effort	1.1	1.3	3.4	-0.7	-0.7	-1.0	0.9	-1.9
Retroperitoneal fat weight	0.1	0.2	0.4	0.2	0.0	-0.6	0.5	-0.4
Reaction time number correct	0.4	0.6	1.5	-1.2	-1.2	0.2	-0.2	-0.4
Reaction time mean minus median	0.6	0.8	1.0	1.0	1.0	-1.0	0.7	-0.6
Reaction time mean minus median AUC	1.7	2.2	2.8	1.6	1.6	-1.7	1.4	-1.2
Reaction time num false alarms	0.9	1.2	1.6	0.9	1.0	-1.1	1.1	-1.3
Reaction time num false alarms AUC	0.9	1.3	2.7	0.6	0.7	-1.1	1.3	-1.6
Reaction time trials correct on left	0.4	0.6	1.5	-1.2	-1.2	0.2	-0.2	-0.4
Reaction time trials on left	0.4	0.6	1.4	-1.2	-1.2	0.1	-0.1	-0.4
Reaction time mean	1.8	2.6	4.8	2.1	2.2	-1.4	1.2	-0.7
Reaction time mean AUC	2.0	2.7	4.7	2.1	2.2	-1.4	1.2	-0.8
Median of all reaction times	1.9	2.7	5.3	2.2	2.3	-1.3	1.1	-0.7
Reaction time omissions	0.4	0.6	1.1	0.5	0.5	-0.7	0.9	-1.0
Reaction time false alarm rate	1.2	1.6	2.0	1.4	1.4	-1.2	1.2	-1.2
Reaction time premature initiation rate	0.2	0.2	0.5	-0.7	-0.7	0.1	0.1	-0.3
Reaction time premature initiations	0.6	0.8	1.9	-1.4	-1.4	0.4	-0.2	-0.3
Std. dev. reaction times	1.8	2.5	3.7	1.8	1.9	-1.5	1.4	-1.1
Reaction time trials completed	0.4	0.6	1.4	-1.2	-1.2	0.1	-0.1	-0.4
Reaction time trials AUC	0.4	0.5	1.3	-1.1	-1.1	0.1	-0.1	-0.4
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.0	0.1	-0.4	0.1	-0.3
Run reversals in cocaine runway, males	1.1	1.0	2.1	0.4	0.2	-0.9	1.4	-1.4
Latency to leave start box in cocaine runway	0.9	1.0	1.7	-1.2	-1.3	0.8	-0.8	0.5
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.2	-0.3	-0.2	0.3	-0.5
Latency to leave start box in cocaine runway, M	4.0	3.8	4.5	-2.0	-2.1	1.5	-2.1	2.0
Std. dev. time between licks in bursts	0.1	0.2	0.6	-0.4	-0.3	0.8	-0.1	0.1
Total sessions with >9 infusions	1.0	1.1	2.7	0.4	0.7	-1.1	1.1	-1.6
Short access day 1 total inactive lever presses	0.3	0.4	1.3	-0.3	0.1	-0.5	0.4	-1.1
Short access day 10 total inactive lever presses	0.9	1.0	1.3	0.9	1.1	-1.1	0.9	-1.0
Short access day 1 total infusions	0.4	0.4	0.6	0.5	0.7	-0.5	0.5	-0.8
Short access day 10 total infusions	0.7	0.8	1.4	1.0	1.2	-0.7	0.8	-0.8
Short access total infusions	1.7	2.0	2.8	1.3	1.7	-1.2	1.2	-1.5
Short access day 1 locomotion	0.0	0.0	0.1	-0.0	0.0	-0.1	0.2	-0.3
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.2	-0.2
Short access total locomotion	0.7	0.7	1.4	0.9	1.2	-0.6	0.5	-0.7
One hour access (0.3 mA shock)	0.5	0.5	0.8	-0.6	-0.5	0.8	-0.9	0.8
Compulsive drug intake	0.6	0.6	1.0	-0.8	-0.7	0.5	-1.0	0.7
One hour access (shock baseline)	0.1	0.1	0.3	0.5	0.6	0.0	0.2	-0.1
Social response proportion	2.1	2.3	3.4	-1.4	-1.2	1.8	-1.6	1.5
Social responses	0.1	0.1	0.2	-0.4	-0.5	0.2	-0.2	0.2
Social time	0.1	0.1	0.2	-0.2	-0.2	-0.4	0.1	-0.3
Soleus weight	7.9	23.0	43.2	-6.4	-6.6	3.8	-3.6	2.0
Bone: stiffness	0.4	0.7	1.7	-1.3	-1.1	0.7	-0.1	-0.5
Tibialis anterior weight	6.2	21.1	40.8	-6.4	-6.2	3.6	-3.4	1.5
Time to tail flick, vehicle, before self-admin	1.3	1.3	2.0	1.1	0.6	-1.4	1.4	-1.0
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.7	-0.8	-0.5	0.6	-0.9	0.5
Time to tail flick, test, before self-admin	0.2	0.2	0.6	0.3	0.2	0.7	-0.3	0.8
Time to tail flick, test, after self-admin	2.2	2.3	2.7	1.5	1.6	-1.4	1.4	-1.4
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	2.3	-0.9	-0.4	1.2	-1.5	1.1
Delta time to tail flick, test, before/after SA	0.5	0.5	0.9	0.3	0.6	-0.9	0.5	-1.0
Tibia length	1.6	4.4	7.2	-1.4	-1.1	2.3	-2.5	2.7
Ambulatory time before self-admin	0.1	0.1	0.3	0.5	0.5	-0.0	0.2	-0.1
Ambulatory time after self-admin	0.6	0.6	1.3	-1.1	-0.7	0.7	-0.9	0.3
Bone: tissue strength	0.5	0.5	1.1	0.9	1.0	-0.4	0.4	-0.2
Total heroin consumption	0.3	0.4	0.7	-0.6	-0.8	-0.2	0.5	-0.7
Bone: trabecular number	0.5	0.8	1.2	1.0	1.1	-0.3	1.0	-0.7
Bone: trabecular spacing	0.0	0.1	0.2	0.2	0.0	-0.4	-0.1	0.3
Bone: trabecular thickness	0.6	0.7	1.1	-0.9	-0.5	1.1	-1.0	0.6
Bone: trabecular tissue density	5.7	8.1	13.7	-3.7	-3.1	2.8	-2.6	1.5
Water consumed over 24 hours	0.1	0.2	0.4	0.1	0.2	0.3	-0.6	0.6
Number of responses in last shaping day	0.1	0.1	0.2	0.1	0.3	-0.4	0.2	-0.5