Pygo1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr8_82581359_82583858	0.03	0.02	5.6e-03	0	0.01	0	0	1.2e-01	3.5e-02	1.7e-01	1.0e-01
2	Adipose	gene expression	Pygo1	0.02	0.02	2.3e-03	0.01	0.02	0.02	0.01	2.1e-02	2.5e-03	4.1e-03	9.0e-03
3	PL	mRNA stability	Pygo1	0.02	0.02	1.0e-02	0.01	-0	-0	0.01	4.4e-02	4.1e-01	4.4e-01	1.7e-02
4	pVTA	gene expression	Pygo1	0.11	0.06	2.7e-06	0.05	0.06	0.06	0.06	6.2e-05	6.8e-06	7.4e-06	1.2e-05
5	NAcc	gene expression	Pygo1	0.02	0.01	8.5e-03	0.01	0.01	0	0.01	6.4e-03	6.6e-03	5.4e-02	1.3e-02
6	PL	gene expression	Pygo1	0.05	0.03	7.9e-05	0.04	0.03	0.03	0.03	5.9e-05	3.3e-04	3.1e-04	2.4e-04
7	Brain	gene expression	Pygo1	0.2	0.09	4.3e-15	0.17	0.16	0.17	0.17	4.9e-16	1.7e-14	2.6e-15	1.3e-15
8	BLA	gene expression	Pygo1	0.15	0.08	2.6e-05	0.05	0.07	0.07	0.07	1.0e-03	2.1e-04	2.0e-04	1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.0	0.1	0.3	0.3	0.3	0.5	-0.0	0.1	0.0	-0.4	0.1
Area under the delay curve	0.7	1.0	1.9	-0.7	-0.7	-0.5	-1.2	0.9	0.9	1.4	-1.4
BMI with tail	5.5	19.0	36.7	-5.6	-6.1	-0.2	-5.0	3.7	4.1	4.4	-3.0
BMI without tail	0.7	3.9	9.9	-2.6	-3.2	1.3	-2.5	1.2	1.4	1.6	-0.9
Body weight	3.9	17.1	26.0	-5.0	-5.1	-1.0	-4.6	4.1	4.4	4.0	-3.3
Weight adjusted by age	0.5	1.6	4.9	-2.1	-2.2	-0.0	-1.0	1.0	0.8	1.0	-0.1
Bone surface	0.1	0.1	0.4	-0.3	-0.4	0.7	-0.2	0.1	0.1	-0.4	0.3
Bone volume	0.1	0.2	0.3	-0.6	-0.6	0.3	-0.6	0.4	0.5	0.1	-0.1
Breakpoint value in progressive ratio session	0.1	0.2	0.6	-0.2	-0.4	0.8	-0.6	-0.1	0.3	0.2	-0.2
Number of licking bursts	1.0	3.1	4.8	2.2	2.1	0.7	1.9	-2.0	-2.1	-1.4	1.2
Context. condit. distance diff. score	0.4	0.4	1.1	-0.3	-0.1	-1.0	-0.5	0.6	0.8	0.7	-0.7
Locomotion velocity, session 1	0.3	0.3	0.5	-0.5	-0.7	0.1	0.5	-0.7	-0.6	-0.2	0.7
Locomotion distance, session 1	0.5	0.7	2.0	0.8	0.6	0.5	0.8	-1.4	-1.1	-0.3	0.6
Locomotion velocity, session 2	0.2	0.2	1.6	0.1	-0.2	1.3	-0.2	-0.2	-0.0	-0.3	0.3
Locomotion distance, session 2	0.5	0.7	3.8	0.1	-0.4	1.9	-0.2	-0.8	-0.5	-0.2	0.5
Locomotion velocity, session 3	2.2	2.5	4.1	1.1	0.7	2.0	1.3	-2.0	-1.6	-1.7	1.8
Locomotion distance, session 3	2.3	2.7	4.3	2.1	1.8	1.5	1.4	-1.9	-1.7	-1.4	1.0
Stereotopy head waving bouts, day 3	0.3	0.4	1.7	-0.9	-0.6	-1.3	0.0	0.2	0.4	0.3	-0.1
Stereotopy head waving duration, day 3	0.6	0.8	2.0	-1.3	-1.0	-1.4	-0.2	0.6	0.8	0.4	-0.1
Locomotion velocity, session 7	0.4	0.4	0.8	0.9	0.8	0.4	0.4	-0.6	-0.8	-0.5	0.2
Locomotion distance, session 7	1.7	2.2	3.4	1.7	1.4	1.5	1.2	-1.6	-1.9	-1.3	1.1
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	-0.6	-0.8	0.5	-0.1	-0.0	-0.1	-0.3	0.3
Stereotopy head waving duration, day 7	0.3	0.4	0.8	-0.4	-0.5	0.6	0.4	-0.2	-0.4	-0.9	0.9
Locomotion velocity, session 8	0.6	0.7	2.2	0.0	-0.1	1.2	0.3	-0.6	-0.5	-1.1	1.5
Locomotion distance, session 8	0.5	0.7	2.3	0.9	0.5	1.5	0.2	-1.0	-0.7	-0.6	0.7
Degree of sensitization distance	0.1	0.1	0.1	0.2	0.2	0.2	0.2	-0.2	-0.3	-0.3	0.4
Degree of sensitization stereotypy	0.2	0.2	0.6	-0.5	-0.7	0.7	-0.1	-0.0	-0.1	-0.3	0.2
Conditioned locomotion	2.9	3.4	6.0	-1.3	-1.4	-0.9	-2.1	1.9	2.2	1.9	-2.5
Cocaine response after cond. corrected	1.4	2.1	5.3	-2.3	-2.0	-1.5	-0.9	1.2	1.3	1.2	-0.2
Cocaine response after cond. not corrected	1.2	1.8	4.1	-2.0	-1.7	-1.7	-0.7	1.1	1.2	1.1	-0.4
Cocaine response before conditioning	0.1	0.2	0.5	0.7	0.6	0.1	-0.1	-0.3	-0.1	0.1	-0.7
Saline control response	0.4	0.6	1.3	0.3	0.4	-0.0	1.1	-0.8	-0.7	-0.9	1.1
Bone: connectivity density	1.9	3.1	4.4	1.9	1.7	1.9	1.5	-1.7	-1.7	-2.1	1.5
Bone: cortical apparent density	0.4	0.7	1.5	1.1	1.2	-0.6	1.0	-0.7	-0.8	-0.3	0.3
Bone: cortical area	1.8	2.9	8.1	-1.5	-0.9	-2.8	-0.7	1.8	1.7	1.8	-1.4
Bone: cortical porosity	0.2	0.2	0.4	0.5	0.7	-0.6	-0.0	0.2	0.4	0.1	-0.4
Bone: cortical porosity	0.3	0.3	0.6	0.4	0.7	-0.6	-0.4	0.7	0.7	0.2	-0.7
Bone: cortical thickness	0.8	1.3	6.2	-0.1	0.5	-2.5	0.2	0.8	0.8	1.2	-1.0
Bone: cortical thickness	0.5	0.6	3.1	-0.1	0.3	-1.8	0.2	0.5	0.6	0.7	-0.3
Bone: cortical tissue density	0.5	0.7	1.6	1.2	1.3	-0.4	1.0	-0.8	-0.9	-0.4	0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.8	0.5	0.1	1.4	-1.1	0.3	0.1	0.3	-1.0
Condit. Reinf. active-inactive response ratio	1.0	1.0	2.8	-0.1	0.1	-1.2	-0.8	1.0	0.9	1.2	-1.7
Condit. Reinf. active responses	1.0	1.3	8.0	0.7	0.1	2.8	-0.7	-0.4	-0.6	-0.8	0.3
Condit. Reinf. inactive responses	3.3	4.2	15.2	1.1	0.4	3.9	0.7	-1.8	-1.7	-2.3	2.3
Incentive salience index mean	0.8	1.0	2.6	0.1	-0.3	1.3	-1.6	0.8	0.7	0.8	-1.4
Condit. Reinf. lever presses	0.6	0.9	2.5	-0.1	-0.5	1.1	-1.6	0.9	0.8	0.7	-1.3
Condit. Reinf. active minus inactive responses	0.6	0.9	2.1	-1.4	-1.4	0.3	-1.1	1.0	1.0	0.2	0.3
Condit. Reinf. active-inactive response ratio	0.9	1.4	2.6	-1.6	-1.4	-0.9	-1.0	1.3	1.4	0.9	-0.4
Condit. Reinf. active responses	0.8	1.1	2.1	-1.3	-1.4	0.5	-1.4	1.2	1.1	0.6	-0.4
Condit. Reinf. inactive responses	0.3	0.4	2.1	0.6	0.3	1.4	-0.3	-0.2	-0.4	-0.5	-0.0
Condit. Reinf. lever presses	0.3	0.5	2.5	-0.0	0.4	-1.6	0.0	0.6	0.5	0.3	-0.5
Condit. Reinf. lever reinforcers received	0.8	1.2	2.2	-1.2	-1.3	0.3	-1.5	1.3	1.2	0.7	-0.5
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.1	0.2	0.0	0.1	0.2
Conditioned reinforcement - inactives	0.1	0.2	0.9	-0.2	0.0	-0.9	0.5	-0.2	-0.2	0.1	0.3
Conditioned locomotion	0.4	0.6	1.2	-0.2	-0.1	-0.5	-0.8	0.9	1.0	0.7	-1.1
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.1	-0.2	0.3	0.3	-0.4	-0.4	-0.1	0.3
Patch foraging indifference point AUC	0.7	1.7	7.8	1.4	0.8	2.8	-0.1	-1.3	-1.0	-0.9	0.2
Delay disc. indifference point, 0s delay	0.5	0.5	1.8	1.0	0.6	1.4	-0.2	-0.7	-0.6	-0.1	-0.2
Delay disc. indifference point, 16s delay	1.4	1.9	3.7	-0.7	-0.5	-1.6	-1.3	1.4	1.3	1.7	-1.9
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.3	0.3	-0.2	0.3	-0.4	-0.3	-0.1	0.2
Delay disc. indifference point, 24s delay	0.1	0.2	0.4	-0.1	-0.0	-0.5	-0.4	0.4	0.4	0.4	-0.6
Delay disc. indifference point, 4s delay	0.5	0.5	1.3	-0.1	-0.1	-0.2	-0.9	0.7	0.8	0.9	-1.1
Delay disc. indifference point, 8s delay	0.5	0.9	1.7	-0.8	-1.1	0.2	-1.3	0.7	0.6	1.3	-1.1
Indifference point function ln k	0.7	2.2	7.7	-1.8	-1.3	-2.8	-0.3	1.2	1.2	1.2	-0.5
Indifference point function log k	0.7	2.2	7.7	-1.8	-1.3	-2.8	-0.3	1.2	1.2	1.2	-0.5
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.2	-0.3	0.0	0.3	-0.4	-0.4	0.1	0.2
Patch foraging total patch changes 12 sec	0.8	1.0	3.2	1.1	0.8	1.8	0.5	-0.9	-0.9	-0.9	0.6
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	0.5	0.3	0.4	0.3	-0.7	-0.6	0.2	-0.1
Patch foraging total patch changes 24 sec	0.6	2.1	4.1	1.2	0.7	2.0	1.1	-1.8	-1.6	-1.3	1.2
Patch foraging total patch changes 6 sec	0.9	1.6	8.0	0.9	0.2	2.8	0.1	-1.2	-1.1	-0.8	0.6
Patch foraging time to switch 0 sec	0.0	0.2	0.7	0.5	0.8	-0.3	0.1	0.5	0.2	-0.3	-0.1
Patch foraging water rate 0 sec	0.2	0.7	2.1	-1.4	-1.5	-0.6	-0.5	0.4	0.4	0.8	-0.3
Patch foraging water rate 12 sec	0.2	0.8	2.7	-1.5	-1.6	-0.1	0.2	0.3	-0.1	0.0	1.0
Patch foraging water rate 18 sec	0.1	0.2	0.6	-0.6	-0.5	-0.8	0.2	0.2	0.0	0.2	0.2
Patch foraging water rate 24 sec	0.9	1.3	2.2	0.9	0.8	0.7	1.4	-1.3	-1.5	-1.2	1.4
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.3	-0.4	-0.2	0.5	-0.4	-0.3	-0.2	0.5
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	1.7	-1.1	-1.3	0.5	-1.0	0.8	0.4	0.7	-0.4
Distance traveled before self-admin	0.0	0.0	0.0	0.1	0.1	-0.0	0.2	0.1	-0.1	-0.2	0.1
Distance traveled after self-admin	0.4	0.7	2.1	-1.3	-1.0	-1.4	0.0	0.5	0.5	0.2	0.1
Extensor digitorum longus weight	3.6	14.5	33.4	-5.5	-5.8	0.5	-4.3	3.5	3.6	2.6	-1.4
Bone: elastic displacement	0.2	0.2	0.5	-0.4	-0.4	0.1	-0.6	0.6	0.4	0.7	-0.4
Bone: elastic work	0.7	0.9	1.6	-0.6	-0.4	-1.0	-0.9	1.3	1.1	1.1	-0.9
Bone: endosteal estimation	0.9	2.2	5.0	-2.2	-2.2	-0.6	-1.5	1.4	1.1	1.2	-0.8
Bone: endosteal perimeter	2.2	5.3	9.2	-3.0	-3.0	-0.8	-2.5	2.6	2.2	2.0	-1.4
Epididymis fat weight	0.2	1.0	3.6	0.7	0.5	1.9	0.4	-0.6	-0.7	-1.2	1.1
Delta time in closed arm before/after self-admin	0.3	0.2	1.1	0.1	0.3	-1.1	0.0	0.1	0.3	0.5	-0.6
Delta time in open arm before/after self-admin	1.6	1.9	3.2	1.2	1.2	0.8	1.6	-1.2	-1.3	-1.7	1.8
Diff in mean of infusions in LGA sessions	1.4	2.6	5.3	-1.6	-1.7	-0.1	-2.3	1.6	1.8	1.7	-1.3
Delay discount exponential model param	0.6	0.8	1.6	0.6	0.7	0.4	1.1	-0.8	-0.8	-1.3	1.2
Extinction: sum of active levers before priming	0.4	0.5	1.0	0.4	0.4	0.5	0.8	-1.0	-0.7	-0.9	0.9
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.6	-0.7	0.4	-0.4	0.3	0.2	0.0	0.3
Bone: final force	1.1	1.8	3.0	-1.5	-1.1	-1.5	-1.1	1.7	1.5	1.2	-1.0
Bone: final moment	1.4	2.2	4.0	-1.5	-1.0	-2.0	-1.1	1.8	1.6	1.4	-1.2
Food consumed during 24 hour testing period	0.3	0.6	2.9	-0.8	-0.5	-1.7	0.5	-0.1	-0.2	0.6	0.1
Glucose	0.2	0.4	0.9	-0.2	-0.3	0.2	0.5	-1.0	-1.0	-0.3	0.8
Heart weight	0.8	1.2	2.7	-0.9	-1.3	1.6	-1.6	0.9	0.7	0.6	-0.7
Delay discount hyperbolic model param	0.7	0.8	1.7	0.5	0.6	0.6	1.1	-0.8	-0.8	-1.3	1.3
Intermittent access intake day 1-15 change	0.1	0.4	1.0	0.0	0.1	-0.1	0.7	-0.9	-0.9	-0.7	1.0
Intermittent access intake escalation	0.0	0.2	0.5	-0.3	-0.2	-0.2	0.4	-0.3	-0.4	-0.4	0.7
Intermittent access intake escalation 2	0.3	0.5	1.0	-1.0	-0.9	-1.0	-0.4	0.5	0.5	0.7	-0.3
Intermitt. access day 1 inactive lever presses	0.0	0.6	4.0	0.1	0.5	-2.0	0.4	-0.3	0.0	0.2	-0.3
Intermitt. access day 15 inactive lever presses	0.0	0.3	0.6	-0.8	-0.6	-0.6	-0.3	0.3	0.6	0.4	-0.2
Intermitt. access escalation Index	0.3	1.0	1.7	-0.5	-0.8	0.6	-1.2	1.1	0.9	1.3	-1.3
Intermittent access day 1 total infusions	0.3	1.0	2.3	1.2	1.5	-0.8	1.4	-0.8	-0.7	-0.6	0.6
Intermittent access day 15 total infusions	0.2	0.6	1.0	0.8	1.0	-0.4	1.0	-0.5	-0.6	-0.7	0.7
Intermittent access terminal intake (last 3 days)	0.1	0.2	1.3	0.2	0.5	-1.1	0.4	0.1	0.1	0.1	-0.1
Intermittent access total infusions	0.7	0.9	2.0	0.8	1.2	-0.8	1.4	-0.9	-0.6	-0.8	0.8
Intermittent access day 1 locomotion	0.8	1.4	3.2	1.5	1.8	-0.5	1.5	-0.8	-0.9	-1.1	0.7
Intermittent access day 15 total locomotion	0.1	0.5	2.6	0.3	0.8	-1.6	0.7	0.2	0.4	0.1	-0.2
Intermittent access total locomotion	0.2	0.2	0.7	0.1	0.4	-0.8	0.7	-0.2	-0.0	-0.3	0.3
Intermittent access standard deviation	0.1	0.3	1.5	-0.1	0.2	-1.2	0.7	-0.5	-0.1	-0.0	0.3
Left kidney weight	0.5	3.7	9.5	-3.1	-2.8	-1.6	-1.3	1.6	1.7	1.4	-0.4
Right kidney weight	0.2	1.6	5.6	-2.3	-2.4	-0.0	-0.8	0.5	0.7	0.4	0.3
Cocaine induced anxiety	0.2	0.7	2.1	-0.2	-0.3	-0.0	-1.1	0.4	0.7	1.1	-1.5
Post-drug Anxiety	1.5	1.7	3.1	1.8	1.6	0.9	1.0	-1.7	-1.4	-1.0	0.5
Baseline Anxiety	3.9	6.6	8.8	2.3	2.2	1.7	2.7	-2.7	-2.9	-3.0	2.8
Tail length	0.7	3.6	6.1	1.9	1.9	1.1	1.9	-1.7	-1.9	-2.5	1.9
Length with tail	0.0	0.1	0.2	-0.3	-0.1	-0.3	0.1	0.4	0.3	-0.5	0.3
Length without tail	1.6	8.6	11.8	-3.4	-3.1	-2.0	-2.7	3.3	3.4	2.8	-2.5
Times rat made contact with spout	0.3	0.4	1.3	0.1	0.1	-1.2	0.5	-0.5	-0.5	0.8	-0.4
Lifetime Intake	0.6	0.7	1.7	0.8	1.1	-0.4	1.3	-0.7	-0.6	-0.8	0.8
Liver weight, left	0.7	1.3	4.5	-1.8	-2.1	0.3	-1.0	0.3	0.6	0.9	-0.2
Liver weight, right	0.4	0.7	2.4	-1.4	-1.6	0.4	-0.8	0.4	0.5	0.3	0.2
Locomotor activity	3.1	4.9	9.3	-3.0	-2.9	-1.3	-2.0	2.4	2.3	1.9	-1.2
Locomotor testing distance	1.2	3.0	6.3	-2.5	-2.3	-1.4	-1.2	1.8	1.6	1.5	-0.6
Locomotor testing rearing	0.1	0.4	1.2	-1.0	-1.1	-0.1	-0.5	0.7	0.4	0.3	0.2
Locomotion in novel chamber	0.5	0.7	3.7	-0.2	0.1	-1.9	0.1	0.2	0.4	0.9	-0.8
Locomotion in novel chamber post-restriction	0.0	0.1	0.3	0.2	0.2	0.1	-0.5	0.3	0.3	0.1	-0.5
Fecal boli incidents, locomotor time 1	0.1	0.3	0.8	0.4	0.2	0.6	-0.5	0.1	0.2	0.5	-0.9
Change in fecal boli incidents, locomotor task	1.0	1.1	6.6	-1.0	-0.5	-2.6	0.7	-0.2	0.1	0.4	0.2
Time >=10cm from walls, locomotor time 1	1.0	1.3	2.3	-1.1	-1.2	-0.5	-1.4	1.1	0.9	1.5	-1.1
Bouts of movement, locomotor time 1	0.2	0.3	0.7	-0.3	-0.5	0.4	-0.6	0.0	0.3	0.8	-0.6
Total resting periods, locomotor time 1	0.1	0.1	0.5	-0.1	-0.3	0.2	-0.4	-0.1	0.1	0.7	-0.5
Rest time, locomotor task time 1	0.9	1.5	3.6	-0.4	-0.3	-1.4	-0.9	0.8	1.0	1.8	-1.9
Distance moved, locomotor task time 1	0.5	1.4	2.7	0.8	0.6	1.6	0.8	-0.9	-1.1	-1.6	1.5
Vertical activity count, locomotor time 1	0.0	0.3	1.1	0.5	0.3	1.1	0.0	-0.1	-0.2	-0.8	0.6
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.8	-0.5	-0.5	-0.7	-0.6	0.5	0.4	1.3	-1.0
Bouts of movement, locomotor time 2	0.1	0.4	1.7	-0.4	-0.8	1.3	-0.4	-0.4	-0.5	0.1	0.1
Total resting periods, locomotor time 2	0.1	0.4	1.8	-0.3	-0.8	1.3	-0.3	-0.6	-0.5	0.1	0.2
Rest time, locomotor task time 2	0.2	0.4	1.7	0.2	0.3	-1.3	0.2	-0.3	0.0	0.7	-0.8
Distance moved, locomotor task time 2	1.3	1.7	3.9	0.8	0.5	2.0	0.7	-0.8	-1.1	-1.7	1.8
Vertical activity count, locomotor time 2	0.8	1.8	2.8	1.4	1.3	1.1	1.3	-1.0	-1.2	-1.7	1.6
Light reinforcement 1	1.0	4.6	7.4	-2.4	-2.7	-0.1	-2.6	1.8	1.9	2.4	-2.0
Light reinforcement 2	0.6	1.3	7.9	-0.2	0.3	-2.8	0.3	0.0	0.5	1.0	-1.2
Bone: marrow area	1.0	2.5	5.4	-2.3	-2.3	-0.8	-1.5	1.5	1.2	1.3	-0.8
Bone: maximum diameter	2.4	4.8	7.9	-2.8	-2.5	-2.1	-1.7	2.3	2.1	2.2	-1.6
Bone: maximum force	1.0	2.0	3.7	-1.5	-1.2	-1.4	-1.2	1.9	1.6	1.2	-1.0
Bone: maximum moment	1.3	2.4	4.0	-1.5	-1.1	-1.9	-1.2	2.0	1.7	1.4	-1.2
Mean time between licks in bursts	0.1	0.4	1.2	0.8	1.1	-0.7	0.8	-0.3	-0.4	-0.5	0.2
Mean num. licks in bursts	1.1	3.1	4.7	-2.2	-1.9	-1.8	-1.5	1.4	1.7	1.9	-1.5
Cd content in liver	0.7	0.8	4.1	1.1	0.8	2.0	-0.2	0.0	-0.2	-0.4	-0.0
Co content in liver	0.9	1.1	3.9	0.2	0.1	-0.1	-1.2	0.8	1.2	1.1	-2.0
Cu content in liver	0.5	0.6	1.2	-0.6	-0.5	-0.2	-0.9	0.9	1.1	0.6	-0.8
Fe content in liver	0.2	0.3	0.7	-0.0	-0.2	0.5	0.3	-0.7	-0.8	-0.3	0.6
K content in liver	0.4	0.4	0.9	-0.8	-0.7	0.8	-0.5	0.6	0.9	-0.3	0.3
Mg content in liver	0.4	0.4	0.8	-0.8	-0.8	0.5	-0.7	0.5	0.9	-0.0	-0.1
Mn content in liver	2.4	2.7	7.2	-1.4	-0.8	-2.7	-0.9	1.5	2.1	1.5	-1.4
Na content in liver	1.2	1.4	4.2	-1.8	-2.1	0.6	-1.3	0.6	0.8	0.7	-0.3
Rb content in liver	0.3	0.4	0.9	-0.6	-0.7	1.0	-0.1	-0.5	0.2	-0.5	0.8
Se content in liver	0.7	0.8	1.6	0.7	0.8	0.2	1.2	-0.8	-0.7	-1.3	1.2
Sr content in liver	0.4	0.4	0.9	1.0	0.8	0.8	0.3	-0.4	-0.5	-0.5	0.2
Zn content in liver	0.6	0.7	1.5	-0.6	-0.5	-0.0	-1.0	1.1	1.2	0.7	-1.0
Bone: minimum diameter	2.1	4.1	6.7	-1.6	-1.2	-2.3	-1.7	2.1	2.0	2.6	-2.4
Time in familiar zone, hab. session 1	0.8	0.9	1.9	-0.5	-0.6	-0.2	-1.1	1.0	1.0	1.2	-1.4
Time in novel zone, hab. session 1	0.6	0.7	1.2	0.6	0.8	-0.3	1.1	-0.7	-0.8	-0.9	1.1
Total zone transitions, hab. session 1	1.2	1.6	3.4	1.2	0.8	1.7	1.0	-1.8	-1.4	-1.0	1.1
Total locomotion distance, hab. session 1	1.0	1.4	3.2	0.9	0.5	1.8	0.8	-1.6	-1.2	-1.1	1.0
Locomotion velocity, hab. session 1	0.6	0.9	2.2	0.6	0.2	1.5	0.6	-1.4	-1.0	-0.8	0.8
Time in familiar zone, hab. session 2	0.6	0.7	1.5	0.7	0.7	0.4	0.9	-1.2	-0.9	-1.0	0.8
Time in novel zone, hab. session 2	1.0	1.1	1.8	-0.9	-0.7	-1.4	-0.6	1.3	1.0	1.2	-0.9
Total zone transitions, hab. session 2	0.6	0.7	4.8	0.2	-0.4	2.2	-0.7	-0.5	-0.2	0.1	-0.1
Total locomotion distance, hab. session 2	0.6	0.7	4.1	-0.1	-0.7	2.0	-1.0	-0.0	0.0	0.2	-0.4
Locomotion velocity, hab. session 2	0.5	0.6	3.0	-0.1	-0.6	1.7	-1.0	0.1	0.2	0.3	-0.6
Novel to familiar place preference ratio	1.2	1.6	2.5	-1.4	-1.4	-0.2	-1.6	1.5	1.5	1.2	-0.8
Novelty place preference	1.6	2.0	2.9	-1.6	-1.5	-0.3	-1.7	1.6	1.6	1.3	-1.0
Time in novel zone, NPP test	1.7	2.1	3.0	-1.7	-1.6	-0.7	-1.6	1.6	1.7	1.4	-1.0
Total zone transitions, NPP test	0.3	0.5	2.3	0.1	-0.5	1.5	-0.4	-0.8	-0.4	0.5	-0.2
Total locomotion distance, NPP test	0.5	0.7	3.3	0.2	-0.3	1.8	0.0	-1.0	-0.8	-0.4	0.5
Locomotion velocity, NPP test	0.9	1.3	5.4	0.7	0.1	2.3	0.3	-1.3	-1.2	-0.8	0.9
Intraocular pressure	0.1	0.1	0.2	0.4	0.3	0.4	0.2	0.0	-0.4	-0.4	0.4
Delta distance traveled before/after self-admin	1.0	1.1	3.1	-1.7	-1.3	-1.8	-0.2	0.6	0.6	0.3	0.1
Delta ambulatory time before/after self-admin	0.7	1.3	4.8	-1.6	-1.1	-2.2	-0.1	0.8	0.9	0.4	-0.1
Parametrial fat weight	1.2	2.9	5.1	2.3	2.2	0.8	1.8	-1.9	-1.7	-1.4	0.8
Pavlov. Cond. lever latency	0.6	0.8	4.5	-0.2	0.3	-2.1	1.2	-0.3	-0.3	-0.2	0.5
Pavlov. Cond. magazine entry latency	1.7	2.2	5.5	0.6	0.3	1.3	-2.1	1.4	1.5	1.1	-2.3
Pavlov. Cond. change in total contacts	1.0	1.1	2.8	0.0	-0.3	1.0	-1.7	0.8	1.1	0.9	-1.5
Pavlov. Cond. index score	0.9	1.1	4.0	1.0	0.5	2.0	-1.3	0.5	0.5	0.3	-1.2
Pavlov. Cond. latency score	0.8	1.0	4.4	1.0	0.4	2.1	-1.1	0.3	0.4	0.1	-1.0
Pavlov. Cond. lever contacts	0.7	0.9	2.6	0.2	-0.2	1.6	-1.4	0.7	0.7	0.6	-1.0
Pavlov. Cond. magazine entry number	1.3	1.6	4.0	-0.8	-0.5	-1.2	1.8	-1.1	-1.2	-0.9	2.0
Pavlov. Cond. intertrial magazine entries	2.4	2.8	4.8	0.9	0.6	1.8	1.5	-1.9	-2.1	-1.8	2.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	4.1	0.9	0.4	2.0	-1.4	0.6	0.6	0.3	-1.3
Pavlov. Cond. response bias	1.7	2.1	4.8	0.3	-0.1	1.3	-2.2	1.5	1.5	1.2	-2.1
Pavlov. Cond. lever latency	0.2	0.3	0.9	-0.2	-0.2	-0.0	0.6	-0.5	-0.4	-0.5	0.9
Pavlov. Cond. magazine entry latency	1.2	1.6	4.3	2.0	2.1	-0.2	1.4	-1.1	-1.0	-0.8	-0.2
Pavlov. Cond. change in total contacts	0.1	0.3	1.0	1.0	1.0	0.2	0.4	-0.3	-0.4	-0.4	-0.2
Pavlov. Cond. index score	0.3	0.4	1.3	1.1	1.2	0.1	0.4	-0.3	-0.3	-0.3	-0.4
Pavlov. Cond. latency score	0.2	0.3	0.9	0.9	1.0	-0.2	0.4	-0.3	-0.3	-0.2	-0.4
Pavlov. Cond. lever contacts	0.1	0.2	0.8	0.3	0.3	-0.0	-0.5	0.3	0.2	0.4	-0.9
Pavlov. Cond. magazine entry number	1.3	1.7	4.3	-2.0	-2.1	-0.1	-1.4	1.1	1.1	0.9	-0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.9	-0.5	-0.6	0.6	0.1	-0.4	-0.4	-0.6	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.7	1.3	1.3	0.1	0.5	-0.5	-0.4	-0.4	-0.3
Pavlov. Cond. response bias	0.3	0.4	1.3	1.1	1.1	0.4	-0.1	0.1	-0.1	0.0	-0.9
Time in closed arm before self-admin	0.1	0.2	0.5	-0.1	-0.2	0.1	-0.7	0.7	0.3	0.6	-0.7
Time in closed arm after self-admin	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	0.0	0.1	0.2	-0.3
Time in open arm before self-admin	0.9	1.1	1.7	-1.3	-1.2	-1.1	-0.9	0.9	1.1	0.9	-1.0
Time in open arm after self-admin	0.1	0.2	0.4	-0.6	-0.5	-0.5	-0.1	0.3	0.4	0.3	0.0
Bone: periosteal estimation	1.5	3.5	5.9	-2.4	-2.1	-1.9	-1.4	1.9	1.7	1.9	-1.3
Bone: periosteal perimeter	1.8	3.5	6.3	-2.5	-2.2	-1.7	-1.5	2.1	1.8	1.8	-1.0
Bone: post-yield work	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.4	0.2	0.3	-0.1	0.1
Progressive ratio test 1 active lever presses	0.4	0.7	1.3	0.9	0.9	0.3	1.1	-0.9	-0.9	-0.8	0.9
Progressive ratio test 1 breakpoint	0.4	0.7	1.3	0.9	1.0	0.2	1.1	-0.9	-0.9	-0.8	0.8
Progressive ratio test 1 inactive lever presses	2.0	5.3	9.4	2.2	2.5	-0.7	3.1	-2.5	-2.4	-2.1	2.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.1	0.4	0.3	0.3	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.4	-0.4	-0.0	0.1	0.4	0.3	0.3	0.1
Progressive ratio test 2 inactive lever presses	0.1	0.3	1.6	0.1	0.5	-1.3	0.8	0.0	0.3	0.1	0.1
Incentive Sensitization - Responses	0.8	2.1	3.2	-1.5	-1.5	-0.6	-1.3	1.8	1.5	1.8	-1.2
Incentive Sensitization - Breakpoint	0.8	1.9	3.0	-1.4	-1.5	-0.4	-1.3	1.7	1.4	1.7	-1.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.0	0.0	0.1	0.4	-0.3	-0.2	-0.5	0.4
Progressive ratio	0.3	0.9	2.8	0.1	-0.1	0.3	-1.4	0.8	1.1	0.9	-1.7
Food seeking constrained by brief footshock	0.6	0.8	1.3	0.2	0.0	1.0	0.8	-1.1	-1.1	-0.8	1.1
Seeking ratio, punishment vs. effort	0.5	1.1	3.9	-0.8	-1.0	0.7	0.9	-0.6	-0.9	-1.0	2.0
Retroperitoneal fat weight	0.6	2.9	4.5	1.8	1.6	1.2	1.9	-2.1	-2.0	-1.5	1.4
Reaction time number correct	0.1	0.4	1.2	-1.0	-1.1	0.4	-0.4	0.4	0.4	-0.3	0.6
Reaction time mean minus median	0.2	1.0	1.8	1.1	1.0	0.6	1.1	-1.3	-1.3	-0.7	0.9
Reaction time mean minus median AUC	0.3	2.3	3.6	1.6	1.5	0.7	1.7	-1.8	-1.9	-1.2	1.4
Reaction time num false alarms	0.7	1.1	1.8	1.0	1.0	0.6	1.2	-1.1	-1.1	-1.1	1.3
Reaction time num false alarms AUC	0.6	1.4	3.0	0.8	0.8	0.8	1.3	-1.2	-1.2	-1.3	1.7
Reaction time trials correct on left	0.1	0.4	1.2	-1.0	-1.1	0.4	-0.4	0.4	0.4	-0.3	0.6
Reaction time trials on left	0.1	0.4	1.1	-1.0	-1.0	0.5	-0.4	0.4	0.3	-0.4	0.7
Reaction time mean	1.0	2.2	4.6	2.0	2.1	-0.3	1.7	-1.6	-1.5	-0.9	0.5
Reaction time mean AUC	0.9	2.2	4.4	2.0	2.1	-0.2	1.7	-1.7	-1.5	-0.9	0.5
Median of all reaction times	1.4	2.3	5.6	2.1	2.4	-0.6	1.7	-1.5	-1.4	-0.8	0.2
Reaction time omissions	0.7	1.1	2.0	0.8	0.7	0.9	1.1	-1.1	-1.2	-1.1	1.4
Reaction time false alarm rate	1.0	1.4	2.1	1.3	1.4	0.3	1.4	-1.3	-1.3	-0.9	1.1
Reaction time premature initiation rate	0.1	0.2	0.6	-0.5	-0.6	0.8	-0.1	-0.1	-0.3	-0.3	0.7
Reaction time premature initiations	0.2	0.5	1.3	-1.0	-1.1	0.8	-0.5	0.2	0.2	-0.3	0.7
Std. dev. reaction times	0.7	2.4	3.6	1.9	1.9	0.4	1.7	-1.7	-1.8	-1.2	1.1
Reaction time trials completed	0.1	0.4	1.1	-1.0	-1.0	0.5	-0.4	0.4	0.3	-0.4	0.7
Reaction time trials AUC	0.1	0.4	1.0	-0.9	-1.0	0.6	-0.4	0.3	0.3	-0.4	0.7
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.1	0.3	-0.4	0.8	-0.6	-0.7	-0.6	0.5
Run reversals in cocaine runway, males	1.1	1.2	5.1	0.4	-0.0	2.3	0.2	-0.9	-0.9	-1.2	1.2
Latency to leave start box in cocaine runway	0.3	0.5	1.4	-1.0	-1.2	0.4	-0.7	0.2	0.4	0.5	-0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	1.3	0.0	-0.1	1.1	0.5	-0.7	-0.6	-0.9	1.0
Latency to leave start box in cocaine runway, M	4.0	3.8	6.2	-2.4	-2.5	-0.9	-2.1	1.5	1.6	2.3	-1.8
Std. dev. time between licks in bursts	0.2	0.3	1.0	-0.2	-0.3	0.6	-0.7	1.0	0.7	-0.1	-0.0
Total sessions with >9 infusions	2.1	2.6	4.3	1.3	1.5	0.5	2.1	-1.4	-1.7	-2.0	2.0
Short access day 1 total inactive lever presses	0.4	0.8	3.3	0.0	0.6	-1.8	1.3	-0.1	-0.2	-0.7	0.8
Short access day 10 total inactive lever presses	0.1	0.6	1.5	0.7	1.0	-1.0	1.2	-0.5	-0.6	-0.4	0.6
Short access day 1 total infusions	0.2	0.5	1.0	0.4	0.6	-0.1	1.0	-0.0	-0.5	-0.9	1.0
Short access day 10 total infusions	0.9	1.5	3.0	1.5	1.7	-0.1	1.6	-1.2	-1.0	-1.1	0.7
Short access total infusions	1.5	2.1	3.6	1.5	1.7	0.2	1.9	-1.3	-1.3	-1.6	1.5
Short access day 1 locomotion	0.0	0.1	0.3	-0.1	-0.0	0.0	-0.1	0.5	0.4	-0.1	-0.1
Short access day 10 total locomotion	0.2	0.8	1.9	0.5	0.8	-1.2	1.4	-1.0	-0.7	-0.7	0.8
Short access total locomotion	0.5	0.7	1.5	0.8	1.1	-0.6	1.2	-0.7	-0.6	-0.8	0.7
One hour access (0.3 mA shock)	1.3	1.5	2.8	-1.2	-1.0	-1.7	-0.7	1.0	1.3	1.5	-1.1
Compulsive drug intake	0.4	0.5	2.4	-1.0	-0.8	-1.5	0.1	0.1	0.1	0.6	-0.0
One hour access (shock baseline)	0.1	0.2	0.4	0.1	0.2	-0.3	-0.1	0.4	0.6	0.5	-0.6
Social response proportion	1.8	2.3	3.8	-1.5	-1.2	-1.2	-1.6	1.8	2.0	1.5	-1.4
Social responses	0.1	0.2	0.3	-0.4	-0.5	-0.0	-0.5	0.4	0.4	0.5	-0.1
Social time	0.1	0.1	0.4	-0.3	-0.2	-0.6	0.4	-0.2	-0.3	-0.1	0.4
Soleus weight	6.5	19.1	47.4	-6.5	-6.9	0.3	-4.8	3.7	3.9	3.0	-1.5
Bone: stiffness	0.2	0.3	1.2	-0.7	-0.6	-0.0	0.3	0.1	-0.1	-0.7	1.1
Tibialis anterior weight	4.5	15.3	40.6	-6.4	-6.4	-0.7	-3.6	3.3	3.5	2.3	-0.4
Time to tail flick, vehicle, before self-admin	1.0	1.2	5.8	1.2	0.6	2.4	-0.1	-1.0	-0.9	-0.6	0.4
Time to tail flick, vehicle, after self-admin	0.1	0.3	1.9	-0.3	0.1	-1.4	0.1	0.4	0.3	0.2	-0.2
Time to tail flick, test, before self-admin	0.6	0.7	1.8	0.4	0.4	-0.1	-1.0	1.1	0.9	0.6	-1.4
Time to tail flick, test, after self-admin	1.2	1.3	2.5	1.5	1.6	0.1	1.2	-1.3	-0.9	-0.9	0.7
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	5.8	-0.4	0.2	-2.4	0.6	0.5	0.3	0.2	-0.3
Delta time to tail flick, test, before/after SA	0.4	0.5	2.2	-0.1	0.2	-1.5	1.1	-0.7	-0.4	0.0	0.6
Tibia length	1.4	4.0	7.0	-1.5	-1.0	-2.6	-1.5	1.9	2.1	2.2	-2.6
Ambulatory time before self-admin	0.1	0.4	0.6	0.8	0.8	0.1	0.7	-0.4	-0.7	-0.6	0.4
Ambulatory time after self-admin	0.4	0.7	3.4	-1.1	-0.6	-1.8	0.4	0.5	0.3	-0.0	0.3
Bone: tissue strength	0.3	0.3	0.7	0.6	0.8	-0.7	0.6	-0.2	-0.3	-0.4	-0.0
Total heroin consumption	0.6	0.7	3.6	-0.4	-0.8	1.9	-0.5	-0.2	0.0	-0.5	0.7
Bone: trabecular number	0.5	0.9	1.7	1.2	1.1	1.3	0.5	-0.6	-0.6	-1.2	0.6
Bone: trabecular spacing	0.1	0.1	0.3	-0.0	-0.2	0.0	-0.1	-0.2	-0.2	0.6	-0.5
Bone: trabecular thickness	0.3	0.5	2.4	-0.6	-0.2	-1.6	0.1	0.7	0.6	0.4	-0.3
Bone: trabecular tissue density	3.1	5.5	11.6	-3.4	-2.8	-2.8	-1.4	2.6	2.4	1.5	-0.7
Water consumed over 24 hours	0.2	0.3	1.1	0.2	0.3	-1.0	0.2	-0.0	-0.1	0.7	-0.8
Number of responses in last shaping day	0.0	0.0	0.1	-0.3	-0.2	0.0	-0.0	0.2	0.0	-0.1	0.2