Hub : Genes

Ighmbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Ighmbp2 0.18 0.1 3.3e-16 0.14 0.16 0.14 0.14 2.5e-15 7.5e-17 1.2e-15 1.4e-15
2 Adipose mRNA stability Ighmbp2 0.16 0.1 1.3e-06 0.01 0.03 0.03 0.02 1.1e-02 3.9e-04 6.5e-04 1.3e-03
3 IL mRNA stability Ighmbp2 0.34 0.19 2.9e-04 0.01 0.07 0.07 0.07 1.8e-01 7.7e-03 1.0e-02 1.0e-02
4 Brain mRNA stability Ighmbp2 0.47 0.11 0.0e+00 0.43 0.39 0.47 0.4 1.6e-43 5.5e-38 6.8e-49 1.5e-39
5 NAcc mRNA stability Ighmbp2 0.15 0.08 6.8e-15 0.09 0.13 0.13 0.13 1.3e-10 2.3e-14 2.0e-14 1.8e-14
6 Liver mRNA stability Ighmbp2 0.03 0.02 7.7e-03 0 0 0 0 1.4e-01 1.3e-01 3.3e-01 2.8e-01
7 BLA mRNA stability Ighmbp2 0.17 0.1 6.3e-06 0.09 0.1 0.1 0.1 2.3e-05 4.6e-06 3.8e-06 9.0e-06
8 Liver gene expression Ighmbp2 0.05 0.03 3.0e-05 0.03 0.03 0.04 0.04 7.8e-04 3.1e-04 8.1e-05 6.8e-05
9 pVTA mRNA stability Ighmbp2 0.16 0.1 2.1e-04 0.08 0.06 0.06 0.07 2.8e-04 8.8e-04 9.0e-04 8.3e-04
10 PL gene expression Ighmbp2 0.03 0.03 8.0e-04 0 0.02 0.02 0.01 1.0e-01 5.9e-03 2.1e-03 3.6e-02
11 OFC mRNA stability Ighmbp2 0.17 0.12 7.2e-03 0.03 0.03 0.11 0.01 8.5e-02 8.2e-02 1.4e-03 1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.50.94.9-0.20.6-0.3-0.50.41.1-0.32.2-0.21.40.4
Area under the delay curve0.30.31.20.10.50.1-0.40.40.7-0.41.0-0.61.1-0.3
BMI with tail0.61.85.2-2.2-1.2-2.31.2-1.4-0.60.81.50.31.50.1
BMI without tail0.40.92.7-1.5-0.8-1.50.8-1.0-0.40.41.70.00.3-0.1
Body weight1.98.115.3-3.9-3.4-3.93.3-3.5-2.92.4-1.01.6-0.52.6
Weight adjusted by age1.01.11.9-1.3-1.3-1.31.2-1.4-1.20.9-0.80.5-0.60.2
Bone surface0.50.93.9-1.4-0.4-1.40.5-0.70.20.32.00.00.90.7
Bone volume0.40.74.5-0.40.4-0.4-0.30.10.9-0.22.1-0.41.00.5
Breakpoint value in progressive ratio session2.02.22.8-1.6-1.5-1.71.5-1.6-1.31.6-1.41.60.11.7
Number of licking bursts0.10.10.80.00.20.0-0.10.00.3-0.00.9-0.0-0.1-0.1
Context. condit. distance diff. score0.91.11.91.11.11.0-1.11.01.1-1.00.4-0.90.9-1.4
Locomotion velocity, session 10.00.00.20.00.10.0-0.10.20.10.00.50.20.20.0
Locomotion distance, session 10.30.41.9-0.30.3-0.3-0.30.20.6-0.51.4-0.81.10.1
Locomotion velocity, session 22.12.55.3-1.8-1.6-1.81.6-1.8-1.51.5-0.41.2-1.02.3
Locomotion distance, session 20.20.30.8-0.7-0.3-0.60.3-0.3-0.0-0.00.9-0.30.20.8
Locomotion velocity, session 30.50.62.80.00.6-0.0-0.50.60.8-0.41.7-0.31.2-0.4
Locomotion distance, session 30.10.10.3-0.00.1-0.0-0.20.10.2-0.30.3-0.50.40.3
Stereotopy head waving bouts, day 30.70.82.30.40.90.4-0.80.81.1-0.61.5-0.51.0-1.2
Stereotopy head waving duration, day 31.21.42.21.11.31.0-1.31.31.4-1.11.5-0.90.9-1.2
Locomotion velocity, session 70.20.21.4-0.10.3-0.2-0.30.10.4-0.30.3-0.41.20.4
Locomotion distance, session 70.20.20.6-0.6-0.5-0.70.4-0.6-0.40.2-0.2-0.10.10.8
Stereotopy head waving bouts, day 71.21.42.80.81.20.8-1.11.21.3-1.11.7-0.91.3-1.0
Stereotopy head waving duration, day 70.40.42.2-0.7-0.1-0.80.2-0.00.20.31.10.51.5-0.1
Locomotion velocity, session 81.41.72.5-1.6-1.4-1.61.4-1.4-1.31.4-0.81.30.01.5
Locomotion distance, session 80.60.92.10.81.00.7-1.00.91.0-1.20.8-1.50.8-0.1
Degree of sensitization distance0.20.20.3-0.5-0.3-0.60.4-0.4-0.20.4-0.10.40.30.5
Degree of sensitization stereotypy0.20.20.9-0.20.1-0.2-0.10.30.3-0.20.9-0.20.9-0.2
Conditioned locomotion3.13.65.9-1.6-2.0-1.52.0-1.8-2.21.7-2.41.6-1.52.4
Cocaine response after cond. corrected0.10.10.30.40.40.4-0.30.40.4-0.1-0.10.20.40.6
Cocaine response after cond. not corrected0.30.30.70.50.70.5-0.50.70.8-0.30.7-0.00.6-0.0
Cocaine response before conditioning0.30.32.10.00.30.1-0.20.20.4-0.21.4-0.2-0.1-1.1
Saline control response2.02.64.3-2.1-1.8-2.11.8-1.9-1.61.8-0.61.5-0.51.3
Bone: connectivity density0.60.93.7-1.3-0.4-1.30.5-0.50.20.41.90.31.30.4
Bone: cortical apparent density1.31.73.3-1.1-1.3-1.11.3-1.1-1.21.6-1.71.80.20.9
Bone: cortical area0.40.61.4-0.6-0.7-0.40.8-0.8-0.70.6-0.70.3-1.21.2
Bone: cortical porosity0.10.10.40.20.30.2-0.30.30.3-0.50.1-0.60.6-0.3
Bone: cortical porosity0.10.10.2-0.5-0.4-0.50.4-0.4-0.30.1-0.2-0.10.10.3
Bone: cortical thickness3.65.97.7-2.4-2.8-2.12.8-2.7-2.72.3-2.31.9-2.42.2
Bone: cortical thickness1.82.12.8-1.5-1.7-1.41.7-1.6-1.61.5-1.01.4-1.31.2
Bone: cortical tissue density1.52.03.8-1.2-1.4-1.31.4-1.2-1.41.7-1.82.00.21.0
Condit. Reinf. active minus inactive responses0.30.31.80.10.40.1-0.40.50.5-0.70.2-0.81.3-0.3
Condit. Reinf. active-inactive response ratio0.60.72.30.50.60.5-0.70.70.8-1.20.4-1.50.9-0.5
Condit. Reinf. active responses0.20.20.80.30.30.3-0.40.50.4-0.6-0.2-0.60.9-0.2
Condit. Reinf. inactive responses0.00.00.30.10.00.1-0.00.2-0.00.2-0.20.50.0-0.0
Incentive salience index mean0.30.41.80.10.30.1-0.40.50.5-0.6-0.2-0.81.30.7
Condit. Reinf. lever presses0.30.42.60.10.10.2-0.10.30.0-0.2-1.0-0.20.61.6
Condit. Reinf. active minus inactive responses1.62.05.51.21.51.1-1.41.81.6-1.11.4-0.72.3-0.5
Condit. Reinf. active-inactive response ratio3.33.45.21.92.01.8-2.02.32.0-2.01.4-1.82.0-0.8
Condit. Reinf. active responses0.71.06.20.30.80.2-0.71.01.0-0.21.10.32.5-0.3
Condit. Reinf. inactive responses0.70.82.0-1.1-0.7-1.20.7-0.8-0.41.20.21.40.90.0
Condit. Reinf. lever presses0.20.31.5-0.7-0.2-0.60.2-0.10.10.41.20.50.60.2
Condit. Reinf. lever reinforcers received0.60.96.30.00.6-0.1-0.50.80.80.10.90.62.5-0.1
Conditioned reinforcement - actives0.20.20.50.40.20.4-0.3-0.1-0.1-0.5-0.7-0.6-0.7-0.2
Conditioned reinforcement - inactives4.04.57.62.72.62.8-2.52.42.3-2.21.0-2.00.5-0.8
Conditioned locomotion5.36.411.93.32.83.5-2.82.52.2-2.90.9-2.8-0.8-1.5
Patch foraging indifference point 0 sec0.10.10.20.30.40.3-0.40.40.30.00.30.40.4-0.4
Patch foraging indifference point AUC1.31.52.4-1.3-1.3-1.21.3-1.1-1.31.3-1.51.2-0.41.1
Delay disc. indifference point, 0s delay0.80.82.80.10.70.1-0.70.70.9-0.71.5-0.91.7-0.6
Delay disc. indifference point, 16s delay1.61.62.71.31.41.3-1.41.21.4-1.51.1-1.70.3-0.8
Delay disc. indifference point, 2s delay0.50.50.80.60.80.5-0.80.70.9-0.80.8-0.90.9-0.0
Delay disc. indifference point, 24s delay0.30.31.0-0.4-0.6-0.40.5-0.7-0.60.5-0.30.4-1.00.4
Delay disc. indifference point, 4s delay0.10.11.0-0.10.2-0.1-0.10.20.20.10.10.11.00.0
Delay disc. indifference point, 8s delay0.10.10.3-0.3-0.0-0.30.1-0.20.10.00.4-0.30.50.0
Indifference point function ln k2.53.45.72.42.22.4-2.12.01.9-1.90.9-1.60.4-1.5
Indifference point function log k2.53.45.72.42.22.4-2.12.01.9-1.90.9-1.60.4-1.5
Patch foraging total patch changes 0 sec0.10.21.0-0.1-0.2-0.10.2-0.1-0.30.6-0.51.0-0.10.2
Patch foraging total patch changes 12 sec2.02.64.0-2.0-1.9-2.01.8-1.5-1.71.8-1.21.90.20.5
Patch foraging total patch changes 18 sec0.30.30.6-0.8-0.6-0.80.5-0.6-0.50.7-0.50.70.10.3
Patch foraging total patch changes 24 sec1.62.02.9-1.4-1.4-1.31.4-1.4-1.41.5-1.11.6-0.91.7
Patch foraging total patch changes 6 sec0.40.61.5-1.2-0.8-1.20.8-0.6-0.60.80.40.80.60.0
Patch foraging time to switch 0 sec0.40.72.3-1.0-0.4-1.20.4-0.50.1-0.11.5-0.51.2-0.6
Patch foraging water rate 0 sec1.01.64.82.01.22.2-1.21.20.6-0.6-1.1-0.1-1.50.2
Patch foraging water rate 12 sec2.74.210.13.02.13.2-2.02.11.5-2.00.3-1.7-1.9-1.3
Patch foraging water rate 18 sec0.91.32.71.61.31.6-1.21.31.0-1.00.5-0.9-0.2-0.9
Patch foraging water rate 24 sec0.71.02.61.50.81.6-0.70.80.3-0.8-1.1-0.8-1.4-0.1
Patch foraging water rate 6 sec0.50.73.11.00.51.2-0.40.30.0-0.4-1.1-0.4-1.70.5
Seeking ratio, delayed vs. immediate footshock0.20.21.6-0.30.1-0.4-0.1-0.10.20.20.30.31.3-0.1
Distance traveled before self-admin0.10.10.5-0.1-0.0-0.1-0.10.10.1-0.60.5-0.70.4-0.6
Distance traveled after self-admin0.20.20.70.10.20.1-0.20.40.3-0.40.8-0.40.4-0.8
Extensor digitorum longus weight5.220.328.0-5.3-5.1-5.25.0-5.2-4.84.1-3.33.0-2.25.1
Bone: elastic displacement0.60.73.40.2-0.40.30.3-0.5-0.8-0.1-1.4-0.4-1.80.6
Bone: elastic work1.62.05.0-1.4-1.6-1.21.6-1.8-1.70.9-0.80.4-2.21.1
Bone: endosteal estimation1.84.07.11.82.31.8-2.21.92.4-2.12.7-2.20.8-1.0
Bone: endosteal perimeter3.47.110.62.63.22.5-3.12.93.3-2.72.6-2.42.4-1.5
Epididymis fat weight3.68.314.73.23.13.2-3.13.12.8-3.61.7-3.80.7-2.0
Delta time in closed arm before/after self-admin1.01.01.8-1.0-1.1-1.01.0-1.3-1.20.5-0.90.2-1.10.8
Delta time in open arm before/after self-admin0.50.40.90.60.60.6-0.60.90.6-0.41.0-0.30.4-1.0
Diff in mean of infusions in LGA sessions0.40.40.6-0.7-0.8-0.70.7-0.8-0.80.5-0.60.5-0.70.3
Delay discount exponential model param0.20.20.8-0.0-0.40.00.3-0.2-0.50.2-0.70.4-0.90.1
Extinction: sum of active levers before priming1.61.63.5-1.8-1.5-1.91.4-1.5-1.21.1-0.60.80.21.1
Active lever presses in extinction session 61.61.62.7-1.2-1.4-1.01.2-1.4-1.50.9-1.60.2-1.11.6
Bone: final force0.91.53.1-1.6-1.2-1.61.3-1.3-1.01.2-0.21.00.01.8
Bone: final moment0.71.22.4-1.5-1.1-1.41.2-1.2-0.91.1-0.10.8-0.21.5
Food consumed during 24 hour testing period0.30.40.70.70.60.8-0.60.50.5-0.70.5-0.7-0.7-0.3
Glucose2.63.95.21.82.11.6-2.12.32.2-1.81.6-1.52.3-2.2
Heart weight1.21.72.61.51.51.5-1.51.61.4-1.40.7-1.11.0-0.8
Delay discount hyperbolic model param0.20.20.9-0.0-0.40.00.3-0.3-0.50.2-0.70.3-0.9-0.0
Intermittent access intake day 1-15 change0.80.82.01.31.11.4-1.10.80.9-0.8-0.3-0.7-0.30.1
Intermittent access intake escalation1.01.02.01.41.31.4-1.31.01.1-0.90.1-0.80.1-0.4
Intermittent access intake escalation 20.40.40.91.00.71.0-0.70.50.6-0.5-0.5-0.4-0.1-0.1
Intermitt. access day 1 inactive lever presses1.11.11.81.31.31.3-1.21.11.1-1.00.8-0.90.3-0.8
Intermitt. access day 15 inactive lever presses2.12.32.91.71.71.6-1.61.71.7-1.51.6-1.30.4-1.4
Intermitt. access escalation Index1.71.52.71.61.41.6-1.51.31.2-1.30.2-1.20.1-0.7
Intermittent access day 1 total infusions4.14.87.22.02.51.9-2.42.42.7-2.02.2-1.72.5-1.3
Intermittent access day 15 total infusions6.37.110.43.13.23.1-3.13.03.1-2.61.8-2.31.5-1.3
Intermittent access terminal intake (last 3 days)4.75.17.62.62.82.5-2.72.52.7-2.21.5-1.91.7-1.0
Intermittent access total infusions3.13.55.32.02.31.9-2.22.12.3-1.71.5-1.31.7-1.0
Intermittent access day 1 locomotion1.71.84.11.11.50.9-1.41.41.7-0.91.4-0.62.0-0.9
Intermittent access day 15 total locomotion3.63.96.02.42.42.4-2.42.22.3-1.91.2-1.51.2-0.9
Intermittent access total locomotion5.96.89.62.83.12.7-3.02.93.1-2.52.2-2.22.3-1.7
Intermittent access standard deviation0.50.51.11.00.91.0-0.90.70.8-0.60.4-0.50.0-0.4
Left kidney weight0.72.14.11.81.41.9-1.51.41.2-1.90.1-2.0-0.3-0.5
Right kidney weight0.41.32.71.51.01.6-1.01.00.6-1.4-0.7-1.6-0.60.0
Cocaine induced anxiety0.10.10.50.20.20.2-0.20.20.2-0.30.7-0.4-0.3-0.3
Post-drug Anxiety1.11.21.8-1.1-1.3-1.11.2-1.3-1.31.0-1.00.7-1.10.4
Baseline Anxiety2.72.94.0-1.7-1.9-1.71.7-1.8-1.82.0-2.01.9-0.71.0
Tail length1.34.05.1-1.9-2.2-1.72.1-2.1-2.21.8-1.91.6-2.02.2
Length with tail2.910.815.7-3.5-3.6-3.33.5-3.6-3.53.1-3.22.6-1.74.0
Length without tail2.35.16.5-2.6-2.5-2.52.4-2.5-2.42.1-2.21.6-0.72.5
Times rat made contact with spout0.20.30.7-0.7-0.3-0.70.3-0.3-0.10.70.50.80.70.5
Lifetime Intake2.42.84.21.72.01.7-1.91.92.0-1.51.4-1.21.6-1.0
Liver weight, left0.30.41.50.60.60.6-0.60.40.6-0.9-0.0-1.20.10.3
Liver weight, right0.30.51.50.60.40.7-0.40.50.2-1.0-0.1-1.2-0.70.6
Locomotor activity0.81.22.21.31.11.4-1.01.10.9-1.40.8-1.5-0.8-0.4
Locomotor testing distance0.71.22.01.41.11.4-1.01.00.8-1.30.7-1.3-1.0-0.8
Locomotor testing rearing1.52.43.01.51.61.5-1.61.61.6-1.71.6-1.60.4-1.7
Locomotion in novel chamber4.65.78.72.82.92.9-2.82.72.7-2.41.6-2.11.4-0.8
Locomotion in novel chamber post-restriction2.53.14.82.22.02.2-1.91.81.8-2.00.8-2.00.7-0.9
Fecal boli incidents, locomotor time 10.10.10.30.30.40.3-0.30.40.3-0.00.10.10.20.5
Change in fecal boli incidents, locomotor task0.30.30.5-0.6-0.5-0.70.5-0.4-0.50.6-0.20.60.3-0.3
Time >=10cm from walls, locomotor time 12.52.57.51.21.71.1-1.51.61.9-1.22.7-0.81.6-1.1
Bouts of movement, locomotor time 11.92.12.8-1.3-1.4-1.21.4-1.5-1.51.6-1.71.6-1.01.6
Total resting periods, locomotor time 11.11.22.1-0.9-1.0-0.81.0-1.2-1.11.1-1.51.1-0.91.4
Rest time, locomotor task time 10.80.91.91.30.91.4-0.90.90.6-1.0-0.1-1.0-1.0-0.2
Distance moved, locomotor task time 10.30.32.2-0.20.2-0.2-0.20.40.4-0.10.50.01.5-0.9
Vertical activity count, locomotor time 11.31.32.11.11.21.0-1.21.21.2-1.10.9-1.11.1-1.4
Time >=10cm from walls, locomotor time 20.00.00.10.30.10.3-0.10.10.0-0.1-0.10.1-0.2-0.1
Bouts of movement, locomotor time 20.50.60.9-0.8-0.9-0.80.9-0.9-0.80.8-0.90.7-0.20.3
Total resting periods, locomotor time 20.20.20.3-0.5-0.5-0.50.5-0.5-0.50.5-0.60.40.0-0.0
Rest time, locomotor task time 22.73.13.81.71.91.7-1.91.92.0-1.71.9-1.61.3-1.4
Distance moved, locomotor task time 21.01.21.8-1.1-1.3-1.01.2-1.2-1.30.8-1.30.7-1.00.8
Vertical activity count, locomotor time 21.11.25.7-0.4-1.0-0.30.9-1.1-1.20.5-1.50.2-2.40.7
Light reinforcement 10.40.71.71.10.81.2-0.90.90.7-0.50.2-0.3-0.2-1.3
Light reinforcement 21.62.24.22.01.72.1-1.71.71.4-1.50.1-1.20.2-1.2
Bone: marrow area1.94.07.21.82.31.8-2.21.92.4-2.12.7-2.20.8-1.1
Bone: maximum diameter0.20.30.60.60.60.7-0.50.40.6-0.50.3-0.6-0.60.4
Bone: maximum force0.40.72.3-1.3-0.5-1.30.5-0.70.00.31.50.00.60.9
Bone: maximum moment0.40.62.5-1.2-0.4-1.10.5-0.70.00.31.6-0.10.30.8
Mean time between licks in bursts1.62.36.5-1.4-1.4-1.41.4-1.3-1.31.6-1.21.70.02.6
Mean num. licks in bursts0.10.10.7-0.2-0.1-0.20.00.1-0.00.2-0.50.40.80.3
Cd content in liver0.91.01.81.31.11.3-1.11.10.9-0.90.4-0.6-0.0-1.2
Co content in liver0.20.20.70.5-0.00.60.00.3-0.20.1-0.80.4-0.6-0.8
Cu content in liver0.20.20.6-0.4-0.5-0.40.4-0.6-0.5-0.1-0.1-0.6-0.8-0.0
Fe content in liver0.00.10.4-0.10.00.0-0.10.10.1-0.50.0-0.60.0-0.0
K content in liver0.40.42.4-0.8-0.3-0.80.3-0.30.1-0.11.6-0.40.3-0.2
Mg content in liver2.12.29.00.51.10.4-1.11.01.4-1.33.0-1.61.1-1.8
Mn content in liver0.50.61.4-1.2-1.0-1.10.9-0.9-0.80.6-0.10.3-0.10.8
Na content in liver0.20.31.6-0.1-0.3-0.00.2-0.4-0.3-0.40.1-0.8-1.30.1
Rb content in liver2.63.25.81.51.81.3-1.72.12.0-1.41.9-0.92.4-2.3
Se content in liver0.60.82.70.40.70.3-0.80.50.8-1.20.9-1.61.0-0.4
Sr content in liver2.42.23.1-1.6-1.7-1.51.7-1.8-1.71.5-1.11.2-1.31.1
Zn content in liver0.40.51.1-0.8-0.9-0.80.8-0.9-0.70.30.0-0.1-1.0-0.0
Bone: minimum diameter1.73.25.41.52.11.5-2.02.02.3-1.62.2-1.41.9-0.6
Time in familiar zone, hab. session 11.31.23.90.91.00.9-0.90.91.2-0.92.0-0.9-0.2-1.5
Time in novel zone, hab. session 10.40.41.5-0.4-0.5-0.50.5-0.5-0.60.6-1.20.80.20.8
Total zone transitions, hab. session 10.20.31.3-0.3-0.1-0.20.1-0.20.1-0.61.2-1.1-0.60.0
Total locomotion distance, hab. session 11.52.15.01.31.41.3-1.41.21.4-1.91.7-2.2-0.3-1.1
Locomotion velocity, hab. session 10.81.13.20.90.90.9-0.90.90.9-1.51.2-1.8-0.4-0.8
Time in familiar zone, hab. session 20.90.91.4-0.8-1.1-0.81.1-1.0-1.11.1-0.61.2-1.00.1
Time in novel zone, hab. session 20.40.41.40.20.60.1-0.60.60.7-0.40.8-0.21.2-0.4
Total zone transitions, hab. session 20.60.84.1-0.90.0-1.00.1-0.10.50.02.0-0.11.50.3
Total locomotion distance, hab. session 20.60.82.10.30.80.3-0.80.81.0-0.81.5-0.81.3-0.7
Locomotion velocity, hab. session 20.91.32.60.71.10.6-1.11.11.3-1.21.6-1.21.2-0.7
Novel to familiar place preference ratio0.10.10.5-0.4-0.2-0.50.1-0.3-0.00.3-0.10.40.70.2
Novelty place preference0.10.10.6-0.10.1-0.2-0.10.00.20.10.10.10.8-0.1
Time in novel zone, NPP test0.10.10.7-0.20.1-0.2-0.10.00.20.10.10.10.9-0.2
Total zone transitions, NPP test0.30.41.3-0.9-0.4-0.90.4-0.5-0.10.31.10.10.40.9
Total locomotion distance, NPP test0.30.41.00.40.60.4-0.60.60.7-0.61.0-0.60.6-0.0
Locomotion velocity, NPP test0.20.31.10.40.60.4-0.60.60.7-0.51.0-0.50.3-0.0
Intraocular pressure0.20.31.50.70.30.7-0.30.5-0.1-0.1-0.10.2-0.7-1.2
Delta distance traveled before/after self-admin0.00.00.10.00.10.10.00.10.10.20.30.3-0.10.0
Delta ambulatory time before/after self-admin0.10.20.5-0.3-0.3-0.20.4-0.2-0.30.6-0.10.7-0.30.5
Parametrial fat weight2.14.25.92.12.32.1-2.32.42.3-1.91.5-1.52.0-1.7
Pavlov. Cond. lever latency0.20.33.00.30.10.3-0.10.1-0.00.00.10.2-0.2-1.7
Pavlov. Cond. magazine entry latency0.30.42.00.20.60.1-0.50.60.8-0.20.90.11.4-0.4
Pavlov. Cond. change in total contacts0.70.71.50.81.00.8-0.91.11.1-0.70.5-0.51.2-0.1
Pavlov. Cond. index score0.20.20.50.40.50.5-0.50.60.6-0.50.1-0.50.30.7
Pavlov. Cond. latency score0.20.20.60.30.50.3-0.40.50.5-0.40.1-0.40.60.8
Pavlov. Cond. lever contacts0.20.21.70.10.30.1-0.20.30.3-0.30.0-0.40.31.3
Pavlov. Cond. magazine entry number0.00.10.1-0.3-0.3-0.30.2-0.4-0.30.10.1-0.1-0.20.1
Pavlov. Cond. intertrial magazine entries0.10.21.20.40.00.4-0.00.1-0.10.2-0.10.3-1.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.30.40.4-0.40.50.5-0.40.1-0.40.40.7
Pavlov. Cond. response bias0.10.20.20.40.40.4-0.40.50.5-0.40.3-0.40.10.5
Pavlov. Cond. lever latency0.20.21.0-0.2-0.3-0.30.3-0.4-0.40.5-1.00.60.00.0
Pavlov. Cond. magazine entry latency1.11.32.9-1.7-1.1-1.71.1-1.0-0.71.20.51.30.90.5
Pavlov. Cond. change in total contacts0.20.21.0-0.30.1-0.3-0.10.20.4-0.01.00.01.0-0.2
Pavlov. Cond. index score0.20.20.7-0.7-0.3-0.70.3-0.2-0.00.20.80.20.60.2
Pavlov. Cond. latency score0.10.10.7-0.5-0.2-0.50.2-0.10.1-0.00.9-0.10.50.2
Pavlov. Cond. lever contacts0.10.10.40.20.20.3-0.10.30.2-0.10.4-0.0-0.30.6
Pavlov. Cond. magazine entry number1.21.43.71.91.31.9-1.21.10.8-1.0-0.6-0.9-0.9-0.8
Pavlov. Cond. intertrial magazine entries0.30.41.01.00.81.0-0.70.60.5-0.3-0.3-0.1-0.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.30.30.8-0.9-0.5-0.90.5-0.4-0.20.50.60.40.60.4
Pavlov. Cond. response bias0.20.20.7-0.5-0.3-0.50.3-0.0-0.10.40.50.50.50.8
Time in closed arm before self-admin0.20.30.80.40.50.3-0.40.40.50.20.90.10.2-0.9
Time in closed arm after self-admin0.40.40.8-0.4-0.5-0.40.5-0.7-0.60.9-0.60.8-0.70.6
Time in open arm before self-admin0.30.30.8-0.4-0.6-0.50.5-0.6-0.6-0.1-0.9-0.3-0.60.5
Time in open arm after self-admin0.10.10.40.1-0.10.1-0.00.2-0.1-0.50.1-0.5-0.2-0.6
Bone: periosteal estimation0.30.61.20.70.80.8-0.80.50.9-0.81.1-1.0-0.40.2
Bone: periosteal perimeter0.20.40.80.50.80.5-0.70.70.9-0.40.6-0.20.90.3
Bone: post-yield work3.44.714.01.02.10.8-2.02.02.7-1.83.7-1.72.8-1.4
Progressive ratio test 1 active lever presses0.70.71.51.21.11.2-1.10.90.9-0.70.1-0.5-0.1-0.1
Progressive ratio test 1 breakpoint0.50.51.21.10.91.1-0.90.80.7-0.6-0.1-0.4-0.20.1
Progressive ratio test 1 inactive lever presses0.40.40.60.80.70.7-0.70.80.7-0.70.5-0.60.4-0.7
Progressive ratio test 2 active lever presses2.22.43.61.91.81.9-1.81.61.6-1.70.9-1.60.2-0.9
Progressive ratio test 2 breakpoint2.42.64.62.11.92.1-1.91.71.6-1.90.6-1.8-0.2-0.8
Progressive ratio test 2 inactive lever presses6.67.610.63.33.23.2-3.23.13.1-2.92.0-2.71.1-1.6
Incentive Sensitization - Responses0.30.30.60.60.60.6-0.60.50.6-0.70.5-0.70.1-0.4
Incentive Sensitization - Breakpoint0.50.50.80.80.80.8-0.80.70.8-0.90.7-0.80.1-0.6
Sum of active levers in priming session hrs 5-61.01.03.8-0.3-0.9-0.10.9-0.6-1.10.4-1.50.3-1.91.1
Progressive ratio1.21.44.8-1.5-0.7-1.70.8-0.6-0.21.20.81.42.20.3
Food seeking constrained by brief footshock0.30.40.6-0.7-0.7-0.80.8-0.6-0.60.7-0.30.8-0.00.0
Seeking ratio, punishment vs. effort0.70.93.91.20.51.3-0.50.40.1-0.8-0.6-0.9-2.0-0.4
Retroperitoneal fat weight4.815.822.24.64.44.6-4.44.34.0-4.72.2-4.71.3-2.6
Reaction time number correct0.30.40.9-0.6-0.7-0.50.7-0.5-0.80.2-0.90.1-0.40.7
Reaction time mean minus median0.40.51.3-1.2-0.9-1.20.9-0.6-0.60.40.70.20.20.2
Reaction time mean minus median AUC0.40.51.1-1.1-1.0-1.01.0-0.5-0.80.40.30.3-0.10.2
Reaction time num false alarms0.40.62.3-0.3-0.7-0.20.6-0.7-0.80.7-0.90.6-1.50.7
Reaction time num false alarms AUC1.21.62.3-1.0-1.3-1.01.3-1.3-1.31.4-1.31.3-1.21.5
Reaction time trials correct on left0.30.40.9-0.6-0.7-0.50.7-0.5-0.80.2-0.90.1-0.40.7
Reaction time trials on left0.40.51.1-0.7-0.9-0.60.8-0.6-0.90.3-1.10.2-0.50.8
Reaction time mean0.30.52.20.20.40.2-0.50.30.5-0.81.5-1.10.1-0.5
Reaction time mean AUC0.50.62.30.30.60.3-0.60.40.6-0.91.5-1.30.3-0.5
Median of all reaction times0.50.62.40.40.70.4-0.70.40.7-0.91.6-1.10.3-0.6
Reaction time omissions0.91.22.2-1.5-1.4-1.41.3-1.2-1.21.0-0.50.8-0.31.1
Reaction time false alarm rate0.50.71.2-0.5-0.7-0.50.7-0.9-0.81.0-0.90.9-1.11.0
Reaction time premature initiation rate1.92.64.1-2.0-2.0-2.01.9-2.0-1.81.5-1.01.1-0.80.7
Reaction time premature initiations3.04.26.4-2.4-2.5-2.42.4-2.4-2.41.8-1.71.4-1.21.3
Std. dev. reaction times0.10.10.7-0.5-0.3-0.60.3-0.2-0.20.00.8-0.10.1-0.2
Reaction time trials completed0.40.51.1-0.7-0.9-0.60.8-0.6-0.90.3-1.10.2-0.50.8
Reaction time trials AUC0.30.40.7-0.6-0.7-0.50.7-0.5-0.70.3-0.90.2-0.40.7
Run reversals in cocaine runway, females0.70.71.9-1.0-0.6-1.10.6-0.5-0.20.71.40.90.6-1.1
Run reversals in cocaine runway, males0.40.41.3-0.3-0.6-0.30.5-0.6-0.80.7-0.60.7-1.20.3
Latency to leave start box in cocaine runway0.70.72.30.40.70.3-0.70.70.9-0.81.5-0.90.9-0.9
Latency to leave start box in cocaine runway, F0.40.41.70.30.50.2-0.40.40.7-0.51.3-0.60.7-1.0
Latency to leave start box in cocaine runway, M0.00.00.10.10.20.1-0.20.20.2-0.20.3-0.20.00.0
Std. dev. time between licks in bursts1.72.15.3-0.9-1.3-0.91.3-1.1-1.51.3-2.11.5-0.52.3
Total sessions with >9 infusions0.50.50.90.80.90.8-0.90.80.9-0.70.4-0.60.6-0.4
Short access day 1 total inactive lever presses2.02.23.01.71.71.7-1.61.71.6-1.31.6-0.90.3-1.4
Short access day 10 total inactive lever presses1.51.72.21.51.41.4-1.31.41.4-1.31.5-1.30.0-1.0
Short access day 1 total infusions2.02.12.81.51.71.4-1.71.51.7-1.51.0-1.31.4-1.4
Short access day 10 total infusions1.31.56.20.71.30.6-1.11.21.5-0.51.4-0.02.5-0.4
Short access total infusions0.60.71.90.61.00.6-0.90.91.1-0.50.7-0.21.4-0.4
Short access day 1 locomotion1.71.92.91.21.61.2-1.51.51.6-1.21.3-1.01.7-1.1
Short access day 10 total locomotion0.70.82.10.71.00.7-0.90.91.1-0.51.1-0.21.4-0.5
Short access total locomotion0.50.51.80.50.80.5-0.80.70.9-0.40.5-0.21.4-0.5
One hour access (0.3 mA shock)6.27.310.23.23.13.2-3.02.92.9-2.92.2-2.70.6-1.8
Compulsive drug intake3.83.96.0-2.2-2.4-2.22.3-2.2-2.41.9-1.21.6-1.60.9
One hour access (shock baseline)7.48.612.83.63.43.6-3.43.23.2-3.11.7-3.00.8-2.1
Social response proportion0.50.51.3-0.8-0.6-0.90.6-0.4-0.40.90.11.11.1-0.1
Social responses0.30.40.6-0.7-0.7-0.60.7-0.5-0.70.7-0.30.7-0.30.5
Social time0.30.40.7-0.8-0.7-0.80.8-0.4-0.60.7-0.20.70.20.3
Soleus weight1.75.111.03.32.63.3-2.62.62.1-2.10.2-1.7-0.1-1.7
Bone: stiffness0.40.61.3-1.0-0.2-1.00.3-0.40.30.51.10.41.11.0
Tibialis anterior weight6.823.434.5-5.3-5.7-5.05.5-5.9-5.53.9-3.52.3-4.84.7
Time to tail flick, vehicle, before self-admin0.60.63.6-0.7-0.1-0.80.1-0.10.20.70.51.11.90.7
Time to tail flick, vehicle, after self-admin1.51.62.9-1.7-1.4-1.71.4-1.2-1.11.4-0.21.30.10.9
Time to tail flick, test, before self-admin0.70.73.20.20.70.1-0.50.80.9-0.21.30.51.8-0.4
Time to tail flick, test, after self-admin0.40.41.3-0.5-0.4-0.50.5-0.3-0.41.1-0.31.10.11.0
Delta time to tail flick, vehicle, before/after SA0.50.50.9-0.9-1.0-0.90.9-0.7-0.90.6-0.20.3-0.60.4
Delta time to tail flick, test, before/after SA3.12.84.9-1.2-1.7-1.11.6-1.6-1.91.9-1.81.5-2.21.6
Tibia length0.41.14.0-0.4-0.7-0.20.7-0.9-0.90.0-1.6-0.7-1.32.0
Ambulatory time before self-admin0.40.41.50.10.20.0-0.30.40.3-0.90.2-1.11.2-0.7
Ambulatory time after self-admin1.51.72.60.91.20.9-1.21.31.4-1.31.6-1.21.5-1.4
Bone: tissue strength1.21.22.70.91.00.9-1.01.01.1-1.31.6-1.4-0.0-0.7
Total heroin consumption3.84.56.1-2.4-2.4-2.52.3-2.1-2.22.4-1.82.4-0.41.5
Bone: trabecular number0.40.73.4-0.30.4-0.4-0.30.40.9-0.11.90.01.40.4
Bone: trabecular spacing0.20.21.60.1-0.30.10.2-0.3-0.50.1-1.3-0.1-0.80.2
Bone: trabecular thickness1.21.54.30.91.40.9-1.21.31.6-0.92.1-0.61.1-0.6
Bone: trabecular tissue density2.43.37.42.72.12.7-2.12.01.6-1.8-0.7-1.5-0.2-0.9
Water consumed over 24 hours0.40.40.9-1.0-0.6-0.90.6-0.9-0.40.70.50.4-0.30.6
Number of responses in last shaping day0.40.40.70.80.60.8-0.70.60.5-0.70.0-0.7-0.2-0.5