Hub : Genes

Ighmbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Ighmbp2 0.11 0.05 3.1e-15 0.08 0.11 0.1 0.11 1.2e-12 6.6e-16 3.0e-15 1.1e-15
2 PL mRNA stability Ighmbp2 0.19 0.1 1.7e-16 0.14 0.15 0.14 0.14 6.3e-15 1.7e-16 4.4e-15 1.1e-14
3 BLA mRNA stability Ighmbp2 0.16 0.1 3.0e-05 0.08 0.08 0.06 0.08 7.1e-05 4.2e-05 7.3e-04 7.1e-05
4 pVTA mRNA stability Ighmbp2 0.07 0.05 3.0e-04 0.03 0.04 0.03 0.04 8.7e-04 1.4e-04 1.3e-03 7.6e-04
5 IL mRNA stability Ighmbp2 0.34 0.18 1.7e-04 0.02 0.1 0.07 0.08 8.9e-02 2.5e-03 8.0e-03 7.1e-03
6 Adipose mRNA stability Ighmbp2 0.17 0.1 1.2e-06 0.01 0.03 0.02 0.02 8.1e-03 3.2e-04 1.7e-03 1.2e-03
7 Brain mRNA stability Ighmbp2 0.47 0.11 0.0e+00 0.45 0.46 0.47 0.47 1.1e-45 1.6e-47 2.9e-48 2.7e-48
8 OFC mRNA stability Ighmbp2 0.18 0.12 6.4e-03 0.03 0.02 0.04 0.05 5.6e-02 9.5e-02 5.3e-02 3.0e-02
9 PL gene expression Ighmbp2 0.03 0.02 1.5e-03 0.01 0.02 0.04 0.01 6.8e-02 5.3e-03 3.5e-05 2.1e-02
10 Liver gene expression Ighmbp2 0.05 0.03 8.3e-05 0.01 0.03 0.03 0.03 9.7e-03 6.2e-04 7.5e-04 2.6e-04
11 pVTA gene expression Ighmbp2 0.04 0.03 2.0e-03 0.03 0.04 0.03 0.03 1.1e-03 6.6e-04 2.2e-03 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.91.76.90.2-0.4-0.10.2-0.60.5-0.40.61.82.62.6
Area under the delay curve0.30.41.90.30.10.10.3-0.10.40.10.21.40.91.0
BMI with tail0.82.811.9-0.9-1.5-1.2-0.9-1.7-0.5-1.1-0.21.82.33.5
BMI without tail0.42.44.8-1.5-1.8-1.6-1.5-1.9-1.3-1.5-1.00.11.52.2
Body weight1.87.912.0-3.1-3.4-3.2-3.1-3.5-2.8-3.1-2.8-0.9-0.22.8
Weight adjusted by age0.41.11.8-1.2-1.0-1.1-1.1-1.1-1.1-1.1-1.4-0.9-1.20.2
Bone surface1.42.710.5-1.0-1.6-1.3-1.0-1.7-0.6-1.5-0.51.42.33.2
Bone volume0.71.45.9-0.0-0.6-0.3-0.1-0.70.2-0.60.31.62.42.4
Breakpoint value in progressive ratio session1.32.43.1-1.5-1.7-1.7-1.6-1.8-1.5-1.8-1.7-0.9-1.21.1
Number of licking bursts0.00.10.40.1-0.00.00.1-0.00.1-0.10.00.60.70.4
Context. condit. distance diff. score0.70.81.21.11.11.01.11.01.01.00.90.80.4-0.2
Locomotion velocity, session 10.00.00.10.10.00.10.10.00.10.00.40.20.20.1
Locomotion distance, session 10.50.72.90.1-0.2-0.00.1-0.30.3-0.00.31.41.41.7
Locomotion velocity, session 21.92.33.2-1.7-1.8-1.7-1.7-1.7-1.6-1.7-1.6-1.2-0.50.9
Locomotion distance, session 20.40.51.6-0.4-0.6-0.4-0.4-0.6-0.2-0.4-0.20.91.31.3
Locomotion velocity, session 30.70.83.00.60.10.30.5-0.00.70.20.91.41.71.5
Locomotion distance, session 30.00.10.30.10.00.10.1-0.00.20.10.20.20.50.4
Stereotopy head waving bouts, day 30.70.82.20.80.50.60.70.30.90.51.11.21.51.1
Stereotopy head waving duration, day 31.11.42.21.31.11.11.21.01.31.11.51.31.40.4
Locomotion velocity, session 70.10.11.20.1-0.1-0.20.0-0.40.2-0.2-0.10.20.41.1
Locomotion distance, session 70.30.40.6-0.6-0.7-0.7-0.6-0.8-0.5-0.7-0.8-0.1-0.10.7
Stereotopy head waving bouts, day 70.81.02.60.90.60.70.80.41.00.71.31.01.61.2
Stereotopy head waving duration, day 70.40.52.9-0.0-0.5-0.4-0.2-0.7-0.0-0.30.40.40.91.7
Locomotion velocity, session 81.41.72.4-1.4-1.5-1.5-1.4-1.5-1.3-1.5-1.3-1.2-0.60.9
Locomotion distance, session 80.60.91.60.90.80.90.90.81.01.00.81.31.10.3
Degree of sensitization distance0.30.30.6-0.5-0.6-0.6-0.5-0.7-0.4-0.7-0.50.2-0.10.8
Degree of sensitization stereotypy0.20.21.10.1-0.1-0.00.1-0.20.20.00.50.20.91.0
Conditioned locomotion2.93.45.2-2.0-1.7-1.7-1.9-1.5-2.1-1.7-2.3-2.2-2.0-0.6
Cocaine response after cond. corrected0.10.10.40.30.30.30.30.30.30.20.20.70.20.0
Cocaine response after cond. not corrected0.30.41.30.60.40.50.60.40.60.40.61.20.80.4
Cocaine response before conditioning0.20.21.30.20.10.20.20.10.30.20.50.71.10.5
Saline control response2.33.14.5-2.0-2.1-2.0-2.0-2.1-1.9-2.0-1.8-0.9-0.61.3
Bone: connectivity density1.42.310.1-0.8-1.4-1.1-0.8-1.6-0.5-1.3-0.21.32.13.2
Bone: cortical apparent density0.50.81.3-0.9-0.7-0.9-0.9-0.7-1.0-1.0-1.0-0.9-1.1-0.4
Bone: cortical area0.30.51.2-0.9-0.7-0.6-0.7-0.5-0.8-0.7-1.1-0.2-0.4-0.3
Bone: cortical porosity0.00.00.20.0-0.00.00.0-0.00.10.1-0.20.4-0.00.2
Bone: cortical porosity0.20.20.4-0.5-0.5-0.5-0.5-0.5-0.4-0.3-0.70.1-0.30.3
Bone: cortical thickness3.66.19.5-2.9-2.5-2.5-2.7-2.2-2.9-2.5-3.1-2.2-2.2-0.5
Bone: cortical thickness1.51.82.5-1.6-1.5-1.4-1.5-1.3-1.6-1.6-1.6-1.0-0.80.1
Bone: cortical tissue density0.71.11.6-1.1-0.9-1.1-1.1-0.9-1.2-1.2-1.1-1.1-1.2-0.3
Condit. Reinf. active minus inactive responses0.20.31.20.30.10.20.30.10.40.40.41.10.60.7
Condit. Reinf. active-inactive response ratio0.40.51.60.50.50.60.60.50.60.80.61.30.80.4
Condit. Reinf. active responses0.10.10.40.30.30.30.30.30.40.50.40.60.00.2
Condit. Reinf. inactive responses0.10.10.40.20.20.20.10.20.10.10.1-0.5-0.6-0.4
Incentive salience index mean0.10.20.90.30.10.20.20.10.30.40.20.90.30.6
Condit. Reinf. lever presses0.00.00.30.10.10.20.10.10.10.2-0.2-0.0-0.6-0.1
Condit. Reinf. active minus inactive responses1.01.53.11.41.01.11.20.91.41.01.81.51.20.8
Condit. Reinf. active-inactive response ratio2.03.25.02.01.81.91.91.72.01.92.21.81.2-0.0
Condit. Reinf. active responses0.40.62.20.70.20.30.5-0.00.70.11.00.90.81.5
Condit. Reinf. inactive responses0.71.12.6-0.8-1.2-1.2-1.0-1.3-0.8-1.4-0.7-0.40.11.6
Condit. Reinf. lever presses0.40.62.6-0.2-0.6-0.4-0.3-0.6-0.1-0.50.30.81.31.6
Condit. Reinf. lever reinforcers received0.30.52.80.5-0.10.00.2-0.30.5-0.20.80.90.71.7
Conditioned reinforcement - actives0.10.41.30.10.30.30.10.40.00.4-0.5-0.9-1.1-1.1
Conditioned reinforcement - inactives1.13.14.42.12.02.12.12.02.01.91.51.50.4-0.8
Conditioned locomotion6.19.013.53.23.53.63.33.73.23.62.61.61.1-2.5
Patch foraging indifference point 0 sec0.00.00.10.40.20.20.30.20.30.10.3-0.1-0.00.0
Patch foraging indifference point AUC0.61.43.2-1.1-1.0-1.0-1.1-0.9-1.1-1.0-1.5-1.6-1.8-0.3
Delay disc. indifference point, 0s delay1.01.14.30.70.30.40.60.10.80.40.82.11.71.6
Delay disc. indifference point, 16s delay1.01.41.91.21.21.31.31.21.31.31.01.41.0-0.3
Delay disc. indifference point, 2s delay0.60.61.20.90.70.80.90.61.00.70.61.10.90.5
Delay disc. indifference point, 24s delay0.20.30.6-0.7-0.5-0.5-0.5-0.4-0.6-0.6-0.6-0.8-0.3-0.4
Delay disc. indifference point, 4s delay0.20.21.10.2-0.0-0.00.1-0.20.2-0.10.11.10.20.8
Delay disc. indifference point, 8s delay0.10.10.5-0.1-0.3-0.2-0.1-0.4-0.0-0.2-0.30.70.30.7
Indifference point function ln k1.33.95.32.22.32.22.22.32.12.12.11.40.9-1.4
Indifference point function log k1.33.95.32.22.32.22.22.32.12.12.11.40.9-1.4
Patch foraging total patch changes 0 sec0.10.21.0-0.2-0.2-0.3-0.3-0.2-0.3-0.4-0.4-1.0-0.9-0.3
Patch foraging total patch changes 12 sec2.23.04.0-1.8-2.0-2.0-1.9-2.0-1.9-1.8-1.7-1.4-1.20.9
Patch foraging total patch changes 18 sec0.30.71.7-0.6-0.8-0.7-0.7-0.8-0.6-0.8-1.0-1.3-1.10.6
Patch foraging total patch changes 24 sec0.51.72.6-1.3-1.3-1.2-1.3-1.2-1.3-1.2-1.6-1.5-1.60.0
Patch foraging total patch changes 6 sec0.61.01.9-0.9-1.3-1.1-1.0-1.3-0.9-1.1-0.7-0.00.31.4
Patch foraging time to switch 0 sec0.41.56.1-0.5-0.9-0.9-0.5-1.2-0.3-0.70.11.32.02.5
Patch foraging water rate 0 sec0.83.210.81.41.81.81.42.21.11.70.8-1.3-1.7-3.3
Patch foraging water rate 12 sec1.66.513.82.32.92.92.53.32.12.92.10.1-0.2-3.7
Patch foraging water rate 18 sec0.71.52.41.31.41.51.31.61.21.51.00.2-0.3-1.5
Patch foraging water rate 24 sec1.31.97.20.91.41.31.01.70.81.30.4-0.7-1.4-2.7
Patch foraging water rate 6 sec1.01.55.70.61.01.00.71.30.51.10.1-1.5-1.7-2.4
Seeking ratio, delayed vs. immediate footshock0.20.31.10.3-0.1-0.00.1-0.20.3-0.20.30.90.91.1
Distance traveled before self-admin0.10.20.90.20.10.20.20.00.30.20.11.00.60.8
Distance traveled after self-admin0.10.10.60.1-0.00.10.10.00.10.20.20.80.60.3
Extensor digitorum longus weight6.023.931.0-5.5-5.5-5.4-5.5-5.3-5.4-5.1-5.6-3.9-3.11.9
Bone: elastic displacement0.81.03.8-0.6-0.1-0.1-0.40.2-0.6-0.0-1.1-1.3-1.9-1.9
Bone: elastic work1.82.33.8-1.9-1.6-1.6-1.7-1.4-1.8-1.5-2.0-1.3-1.1-0.4
Bone: endosteal estimation1.63.97.22.01.71.92.01.62.21.81.92.52.70.5
Bone: endosteal perimeter2.86.89.43.02.62.72.92.33.12.52.82.92.50.7
Epididymis fat weight2.613.218.24.04.24.24.04.33.94.23.82.31.3-2.3
Delta time in closed arm before/after self-admin1.41.31.8-1.3-1.2-1.2-1.3-1.2-1.3-1.0-1.2-1.1-1.10.1
Delta time in open arm before/after self-admin0.40.52.00.50.40.40.50.30.50.31.01.11.40.5
Diff in mean of infusions in LGA sessions0.50.91.1-0.9-1.0-1.0-1.0-1.0-1.0-1.0-0.8-1.0-0.90.3
Delay discount exponential model param0.20.21.2-0.20.0-0.0-0.20.1-0.30.0-0.0-1.1-0.7-0.9
Extinction: sum of active levers before priming0.71.12.3-1.0-1.2-1.2-1.1-1.4-0.9-1.1-0.80.1-0.11.5
Active lever presses in extinction session 61.11.11.6-1.2-1.2-1.1-1.2-1.1-1.2-0.9-1.3-0.9-0.90.1
Bone: final force0.81.31.9-1.2-1.4-1.3-1.2-1.4-1.0-1.3-1.20.00.11.2
Bone: final moment0.81.21.9-1.2-1.4-1.2-1.2-1.3-1.0-1.3-1.30.10.21.1
Food consumed during 24 hour testing period0.20.50.80.60.70.80.70.90.60.70.60.60.6-0.8
Glucose2.64.26.52.41.92.02.21.72.41.82.52.12.10.9
Heart weight0.71.12.31.00.50.70.90.41.10.51.11.51.31.4
Delay discount hyperbolic model param0.20.31.5-0.3-0.1-0.1-0.30.0-0.4-0.1-0.2-1.2-0.8-0.9
Intermittent access intake day 1-15 change0.63.25.32.12.22.22.12.32.01.90.90.8-0.3-1.5
Intermittent access intake escalation0.52.74.51.92.02.01.92.11.81.70.70.6-0.5-1.5
Intermittent access intake escalation 21.32.23.61.71.91.81.81.91.71.50.60.7-0.7-1.2
Intermitt. access day 1 inactive lever presses0.00.00.1-0.00.1-0.1-0.00.0-0.0-0.2-0.0-0.3-0.1-0.2
Intermitt. access day 15 inactive lever presses0.42.33.01.71.61.61.71.51.71.41.61.71.40.0
Intermitt. access escalation Index0.72.23.61.51.81.81.61.91.51.81.20.40.4-1.7
Intermittent access day 1 total infusions1.13.36.92.01.61.71.91.42.11.41.72.61.91.1
Intermittent access day 15 total infusions2.86.89.63.13.03.13.13.03.12.72.12.21.1-0.9
Intermittent access terminal intake (last 3 days)3.25.58.32.92.72.72.82.52.92.31.82.30.9-0.3
Intermittent access total infusions2.83.35.02.21.92.02.11.82.21.71.42.11.00.2
Intermittent access day 1 locomotion0.81.53.11.41.21.21.41.01.41.01.11.81.10.5
Intermittent access day 15 total locomotion1.76.79.43.13.03.03.12.93.02.72.22.31.2-0.7
Intermittent access total locomotion7.69.112.53.53.43.43.53.23.53.12.83.01.7-0.5
Intermittent access standard deviation0.21.21.61.21.31.21.31.21.31.00.81.20.7-0.4
Left kidney weight0.65.06.42.42.52.52.52.52.42.52.41.81.6-1.0
Right kidney weight0.43.04.51.82.02.01.92.11.71.91.71.10.6-1.5
Cocaine induced anxiety0.10.20.90.30.20.20.30.20.30.20.50.30.90.4
Post-drug Anxiety0.20.30.4-0.6-0.6-0.6-0.5-0.6-0.5-0.5-0.4-0.40.20.6
Baseline Anxiety0.40.71.0-0.9-0.8-1.0-0.9-0.9-1.0-0.8-0.9-0.7-0.90.1
Tail length0.95.08.2-2.4-2.2-2.2-2.3-2.0-2.4-2.1-2.9-2.8-1.9-0.3
Length with tail2.511.116.2-3.7-3.6-3.5-3.6-3.4-3.6-3.3-4.0-3.3-2.80.6
Length without tail1.36.79.4-2.8-2.8-2.8-2.8-2.7-2.8-2.7-3.1-2.0-2.40.7
Times rat made contact with spout0.40.41.5-0.3-0.6-0.5-0.4-0.7-0.3-0.7-0.10.70.91.2
Lifetime Intake1.41.72.71.61.41.51.61.31.61.21.01.50.60.2
Liver weight, left0.20.31.50.20.50.40.30.60.20.2-0.2-0.6-0.7-1.2
Liver weight, right0.61.02.11.01.21.11.01.30.91.00.6-0.3-0.4-1.4
Locomotor activity0.81.32.21.01.31.41.21.41.11.50.90.60.3-1.3
Locomotor testing distance0.61.52.41.11.41.41.21.51.11.51.10.60.5-1.5
Locomotor testing rearing0.72.53.41.61.51.71.61.61.61.71.81.71.6-0.2
Locomotion in novel chamber5.06.79.03.02.83.02.92.93.02.72.52.41.6-0.9
Locomotion in novel chamber post-restriction1.54.46.12.32.52.42.42.42.32.31.81.81.0-1.1
Fecal boli incidents, locomotor time 10.00.10.10.40.30.40.30.40.30.20.30.30.3-0.2
Change in fecal boli incidents, locomotor task0.20.20.3-0.4-0.5-0.5-0.4-0.6-0.4-0.4-0.3-0.2-0.10.4
Time >=10cm from walls, locomotor time 12.22.85.71.81.31.51.61.21.81.42.02.02.40.8
Bouts of movement, locomotor time 11.52.03.8-1.5-1.3-1.4-1.5-1.3-1.5-1.5-1.3-1.9-1.5-0.3
Total resting periods, locomotor time 10.91.02.4-1.0-0.9-0.9-1.0-0.8-1.0-1.0-1.0-1.6-1.2-0.5
Rest time, locomotor task time 11.11.72.81.21.51.51.31.71.21.61.20.40.3-1.7
Distance moved, locomotor task time 10.10.31.70.2-0.1-0.10.1-0.30.2-0.10.11.00.51.3
Vertical activity count, locomotor time 10.21.12.11.11.11.01.10.91.20.91.11.40.90.3
Time >=10cm from walls, locomotor time 20.00.10.40.20.30.30.20.30.10.3-0.2-0.3-0.4-0.7
Bouts of movement, locomotor time 20.20.60.9-0.9-0.8-0.9-0.9-0.8-0.9-0.9-0.9-0.5-0.60.3
Total resting periods, locomotor time 20.00.20.3-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.1-0.10.3
Rest time, locomotor task time 22.13.65.81.91.81.91.91.82.01.82.22.42.2-0.1
Distance moved, locomotor task time 21.41.83.6-1.3-1.2-1.2-1.3-1.1-1.4-1.0-1.6-1.7-1.9-0.3
Vertical activity count, locomotor time 20.61.44.2-1.0-0.5-0.6-0.8-0.3-1.0-0.5-1.5-1.9-2.0-1.5
Light reinforcement 10.10.71.20.91.01.00.91.10.80.80.6-0.2-0.3-1.0
Light reinforcement 21.12.54.01.71.91.91.72.01.61.91.20.3-0.3-1.5
Bone: marrow area1.74.17.22.01.81.92.11.72.21.82.02.62.70.5
Bone: maximum diameter0.20.30.50.50.60.70.60.70.60.50.30.60.5-0.5
Bone: maximum force0.81.65.6-0.8-1.2-0.9-0.8-1.3-0.4-1.0-0.51.41.82.4
Bone: maximum moment0.81.54.9-0.8-1.2-0.9-0.8-1.3-0.5-1.0-0.51.41.82.2
Mean time between licks in bursts0.21.21.7-1.1-1.2-1.2-1.2-1.2-1.1-1.3-1.2-0.9-0.80.5
Mean num. licks in bursts0.00.00.10.0-0.1-0.1-0.1-0.2-0.0-0.10.20.00.00.4
Cd content in liver1.71.82.41.51.51.51.51.51.41.41.51.40.9-0.7
Co content in liver0.50.63.70.20.60.40.20.8-0.10.5-0.0-0.7-1.2-1.9
Cu content in liver0.00.00.10.00.20.10.10.20.10.3-0.20.3-0.3-0.3
Fe content in liver0.20.20.7-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.8-0.5-0.90.0
K content in liver0.30.20.8-0.2-0.3-0.3-0.2-0.4-0.1-0.10.00.90.90.8
Mg content in liver1.11.22.60.90.90.91.00.91.01.11.41.61.60.2
Mn content in liver1.41.62.4-1.4-1.6-1.5-1.5-1.5-1.4-1.3-1.3-0.4-0.60.9
Na content in liver0.10.10.8-0.20.10.1-0.10.2-0.20.2-0.2-0.4-0.1-0.9
Rb content in liver1.31.52.61.51.31.21.41.11.41.11.61.40.70.3
Se content in liver0.30.31.10.50.50.40.50.30.60.60.21.10.30.4
Sr content in liver1.71.42.3-1.5-1.4-1.3-1.4-1.2-1.5-1.1-1.4-1.1-0.6-0.1
Zn content in liver0.50.50.9-0.9-0.7-0.8-0.8-0.6-0.9-0.7-0.8-0.7-0.6-0.3
Bone: minimum diameter1.83.47.61.91.51.71.91.42.11.51.82.82.31.0
Time in familiar zone, hab. session 10.91.02.01.00.91.01.11.01.10.90.91.41.20.1
Time in novel zone, hab. session 10.20.30.8-0.5-0.4-0.6-0.5-0.5-0.5-0.5-0.2-0.9-0.4-0.1
Total zone transitions, hab. session 10.20.21.4-0.3-0.3-0.1-0.2-0.2-0.10.00.00.61.20.7
Total locomotion distance, hab. session 11.11.62.31.21.21.41.31.31.31.51.31.31.3-0.2
Locomotion velocity, hab. session 10.50.71.30.70.81.00.90.90.91.10.80.90.9-0.2
Time in familiar zone, hab. session 20.80.91.4-1.0-0.8-0.9-0.9-0.7-1.0-1.0-1.2-1.0-0.9-0.3
Time in novel zone, hab. session 20.40.41.20.50.30.30.40.10.60.30.90.91.11.0
Total zone transitions, hab. session 21.21.67.5-0.1-0.8-0.5-0.2-1.00.1-0.60.31.72.22.7
Total locomotion distance, hab. session 20.60.82.40.70.40.50.60.20.80.50.91.41.51.3
Locomotion velocity, hab. session 20.91.32.81.00.70.91.00.61.10.91.21.61.71.1
Novel to familiar place preference ratio0.10.20.8-0.2-0.4-0.4-0.2-0.5-0.2-0.40.00.30.60.9
Novelty place preference0.10.20.60.1-0.1-0.10.1-0.20.2-0.10.30.50.80.8
Time in novel zone, NPP test0.10.10.70.1-0.1-0.10.0-0.20.1-0.10.30.40.70.8
Total zone transitions, NPP test0.50.72.9-0.5-0.9-0.6-0.5-0.9-0.3-0.7-0.20.41.31.7
Total locomotion distance, NPP test0.30.41.10.60.40.50.50.30.60.50.70.91.00.6
Locomotion velocity, NPP test0.30.41.20.50.40.50.50.40.60.50.70.81.10.4
Intraocular pressure0.30.52.60.40.70.60.40.90.30.70.6-0.4-0.4-1.6
Delta distance traveled before/after self-admin0.00.00.1-0.2-0.3-0.2-0.3-0.1-0.3-0.20.0-0.20.0-0.3
Delta ambulatory time before/after self-admin0.10.10.2-0.4-0.4-0.3-0.5-0.3-0.5-0.4-0.4-0.3-0.3-0.3
Parametrial fat weight2.66.28.32.92.82.72.82.62.82.42.92.31.5-0.7
Pavlov. Cond. lever latency0.10.10.40.40.50.30.30.50.20.30.40.2-0.0-0.6
Pavlov. Cond. magazine entry latency0.20.31.00.50.20.30.40.10.60.20.70.70.81.0
Pavlov. Cond. change in total contacts0.60.71.01.00.80.80.90.71.00.81.00.90.60.3
Pavlov. Cond. index score0.10.10.20.40.30.40.40.40.50.50.30.30.30.1
Pavlov. Cond. latency score0.10.10.10.30.20.30.30.20.40.30.20.30.30.3
Pavlov. Cond. lever contacts0.00.00.10.1-0.10.10.1-0.00.20.10.00.10.20.4
Pavlov. Cond. magazine entry number0.00.00.1-0.3-0.2-0.2-0.3-0.2-0.3-0.3-0.30.10.00.1
Pavlov. Cond. intertrial magazine entries0.10.21.10.10.30.30.20.50.00.20.1-0.1-0.4-1.1
Pavlov. Cond. lever-magazine prob. diff.0.10.20.20.40.30.40.40.40.50.50.40.40.30.1
Pavlov. Cond. response bias0.10.10.10.30.30.40.30.40.30.40.30.00.2-0.2
Pavlov. Cond. lever latency0.10.10.5-0.2-0.2-0.3-0.2-0.3-0.2-0.2-0.3-0.3-0.70.0
Pavlov. Cond. magazine entry latency1.52.25.5-1.3-1.7-1.6-1.4-1.9-1.2-1.7-0.90.20.72.3
Pavlov. Cond. change in total contacts0.10.31.50.1-0.2-0.10.0-0.30.2-0.30.30.81.01.2
Pavlov. Cond. index score0.30.51.8-0.4-0.7-0.5-0.4-0.7-0.3-0.6-0.20.50.81.3
Pavlov. Cond. latency score0.20.31.3-0.3-0.5-0.4-0.3-0.6-0.2-0.5-0.20.50.81.1
Pavlov. Cond. lever contacts0.10.10.60.20.10.20.20.20.20.10.40.40.80.2
Pavlov. Cond. magazine entry number2.02.66.21.51.91.81.62.11.31.81.1-0.3-0.6-2.5
Pavlov. Cond. intertrial magazine entries0.40.81.40.91.00.90.91.00.80.90.9-0.5-0.4-1.2
Pavlov. Cond. lever-magazine prob. diff.0.40.72.2-0.6-0.9-0.8-0.7-1.0-0.5-0.8-0.40.40.81.5
Pavlov. Cond. response bias0.30.41.9-0.3-0.7-0.5-0.4-0.7-0.3-0.6-0.00.50.91.4
Time in closed arm before self-admin0.71.22.61.21.01.01.10.91.20.61.31.21.60.3
Time in closed arm after self-admin0.00.00.20.0-0.0-0.0-0.00.0-0.0-0.4-0.1-0.5-0.2-0.2
Time in open arm before self-admin1.11.43.3-1.2-0.9-1.0-1.1-0.8-1.2-0.7-1.5-1.5-1.8-0.4
Time in open arm after self-admin0.30.30.5-0.6-0.6-0.7-0.6-0.7-0.6-0.4-0.40.2-0.10.6
Bone: periosteal estimation0.30.61.70.60.60.80.80.70.80.60.41.31.30.1
Bone: periosteal perimeter0.30.51.30.80.50.60.70.40.80.50.81.20.90.7
Bone: post-yield work3.05.115.11.70.91.11.60.52.00.92.23.73.93.2
Progressive ratio test 1 active lever presses0.00.10.4-0.1-0.1-0.1-0.1-0.0-0.1-0.2-0.3-0.5-0.6-0.3
Progressive ratio test 1 breakpoint0.10.10.4-0.1-0.1-0.1-0.2-0.1-0.2-0.2-0.3-0.5-0.6-0.3
Progressive ratio test 1 inactive lever presses0.00.00.00.00.10.00.00.10.0-0.00.0-0.0-0.1-0.2
Progressive ratio test 2 active lever presses1.11.62.31.51.51.51.51.41.51.41.00.80.4-0.5
Progressive ratio test 2 breakpoint1.11.42.11.41.41.41.41.41.41.40.90.70.3-0.5
Progressive ratio test 2 inactive lever presses2.68.311.53.33.33.43.43.33.33.22.32.31.2-1.2
Incentive Sensitization - Responses0.10.20.70.30.10.20.3-0.00.40.10.30.60.80.8
Incentive Sensitization - Breakpoint0.10.30.70.50.30.40.50.20.60.40.50.60.80.7
Sum of active levers in priming session hrs 5-61.01.04.0-0.6-0.1-0.1-0.40.2-0.70.2-0.7-1.5-1.6-2.0
Progressive ratio0.51.58.4-0.2-1.0-0.8-0.5-1.3-0.2-0.90.11.31.42.9
Food seeking constrained by brief footshock0.10.20.3-0.4-0.4-0.5-0.4-0.5-0.4-0.4-0.1-0.3-0.00.6
Seeking ratio, punishment vs. effort0.51.05.00.41.00.80.61.20.30.90.3-1.0-0.8-2.2
Retroperitoneal fat weight6.629.639.46.16.36.26.16.35.96.05.83.72.7-3.0
Reaction time number correct0.20.51.5-0.7-0.6-0.4-0.6-0.4-0.7-0.3-0.9-1.1-1.2-0.4
Reaction time mean minus median0.21.22.0-1.1-1.3-1.2-1.2-1.4-1.0-1.1-0.5-0.00.81.4
Reaction time mean minus median AUC0.10.91.5-1.1-1.2-1.1-1.2-1.1-1.1-0.9-0.6-0.20.40.8
Reaction time num false alarms0.30.51.8-0.6-0.3-0.3-0.5-0.1-0.6-0.4-0.8-0.9-1.4-1.0
Reaction time num false alarms AUC0.61.33.0-1.2-1.0-1.0-1.1-0.9-1.2-1.0-1.4-1.1-1.7-0.4
Reaction time trials correct on left0.20.51.5-0.7-0.6-0.4-0.6-0.4-0.7-0.3-0.9-1.1-1.2-0.4
Reaction time trials on left0.20.71.7-0.8-0.7-0.6-0.8-0.5-0.8-0.4-1.1-1.2-1.3-0.4
Reaction time mean0.20.42.40.20.10.20.20.00.40.20.70.71.50.7
Reaction time mean AUC0.20.52.40.40.30.30.40.20.60.30.80.81.50.7
Median of all reaction times0.50.72.90.70.50.50.70.40.80.51.10.91.70.6
Reaction time omissions1.32.03.0-1.6-1.7-1.6-1.6-1.7-1.5-1.6-1.4-0.7-0.11.1
Reaction time false alarm rate0.30.41.1-0.7-0.5-0.6-0.6-0.4-0.7-0.7-0.8-0.6-1.1-0.5
Reaction time premature initiation rate2.23.44.5-2.1-2.1-2.1-2.0-2.1-2.0-2.0-2.0-1.4-1.01.0
Reaction time premature initiations1.75.16.8-2.6-2.5-2.4-2.5-2.4-2.5-2.2-2.6-2.1-1.80.6
Std. dev. reaction times0.10.40.9-0.5-0.7-0.6-0.6-0.8-0.5-0.70.00.20.91.0
Reaction time trials completed0.20.71.7-0.8-0.7-0.6-0.8-0.5-0.8-0.4-1.1-1.2-1.3-0.4
Reaction time trials AUC0.20.61.3-0.7-0.6-0.5-0.7-0.4-0.7-0.3-1.0-1.1-1.2-0.4
Run reversals in cocaine runway, females0.60.62.1-0.5-0.8-0.8-0.6-0.9-0.5-0.8-0.10.51.11.4
Run reversals in cocaine runway, males0.30.30.9-0.4-0.2-0.3-0.4-0.1-0.5-0.4-0.3-0.9-0.7-0.8
Latency to leave start box in cocaine runway0.70.92.30.80.70.70.80.50.90.81.01.31.50.9
Latency to leave start box in cocaine runway, F0.50.72.30.60.50.50.70.30.70.60.71.21.50.9
Latency to leave start box in cocaine runway, M0.00.00.00.10.00.00.1-0.00.10.20.10.00.10.2
Std. dev. time between licks in bursts1.12.15.6-1.3-1.1-1.2-1.3-1.0-1.4-1.2-1.9-1.8-2.4-0.8
Total sessions with >9 infusions0.20.20.5-0.3-0.5-0.4-0.4-0.5-0.3-0.5-0.7-0.1-0.60.6
Short access day 1 total inactive lever presses0.91.82.41.51.51.51.51.51.41.31.51.01.1-0.7
Short access day 10 total inactive lever presses0.00.10.70.10.20.10.20.20.10.10.70.10.8-0.0
Short access day 1 total infusions0.40.81.21.11.11.01.11.01.11.00.70.80.4-0.2
Short access day 10 total infusions0.30.52.10.70.10.30.5-0.00.7-0.10.21.40.71.4
Short access total infusions0.10.10.60.40.10.10.2-0.00.3-0.00.10.70.20.8
Short access day 1 locomotion0.61.01.31.11.11.11.11.01.11.00.90.90.6-0.2
Short access day 10 total locomotion0.20.81.41.10.90.91.00.71.00.80.91.20.90.4
Short access total locomotion0.60.91.41.21.01.01.10.91.21.00.81.20.50.1
One hour access (0.3 mA shock)4.14.86.52.52.52.62.52.52.52.41.81.91.1-0.8
Compulsive drug intake2.63.85.6-2.3-2.2-2.2-2.4-2.1-2.4-1.9-1.7-1.9-1.10.1
One hour access (shock baseline)2.97.610.83.23.33.33.33.23.23.02.12.10.9-1.2
Social response proportion0.30.31.0-0.4-0.6-0.7-0.5-0.8-0.4-0.7-0.10.30.01.0
Social responses0.20.30.5-0.6-0.7-0.6-0.7-0.6-0.7-0.5-0.4-0.2-0.40.1
Social time0.20.40.6-0.7-0.8-0.7-0.7-0.8-0.7-0.6-0.20.4-0.00.5
Soleus weight2.47.111.32.83.23.12.83.42.62.92.40.60.2-3.1
Bone: stiffness0.61.14.8-0.3-0.8-0.6-0.4-0.9-0.1-0.8-0.21.41.52.2
Tibialis anterior weight7.024.034.6-5.9-5.4-5.2-5.5-4.8-5.6-4.7-5.9-4.6-3.30.3
Time to tail flick, vehicle, before self-admin0.40.52.6-0.0-0.5-0.4-0.2-0.70.0-0.8-0.10.80.51.6
Time to tail flick, vehicle, after self-admin0.51.03.7-0.7-1.1-1.0-0.8-1.2-0.6-0.9-0.30.80.81.9
Time to tail flick, test, before self-admin1.41.64.01.30.81.01.10.71.30.91.32.01.71.1
Time to tail flick, test, after self-admin0.10.10.5-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.2-0.7-0.1-0.2
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.6-0.7-0.6-0.6-0.7-0.6-0.3-0.3-0.20.50.8
Delta time to tail flick, test, before/after SA2.53.17.9-1.7-1.2-1.4-1.6-1.0-1.9-1.4-1.8-2.8-2.2-1.6
Tibia length0.30.82.3-0.8-0.5-0.4-0.6-0.2-0.7-0.2-1.3-1.0-1.5-1.2
Ambulatory time before self-admin0.10.31.10.40.30.30.40.10.50.30.21.00.60.9
Ambulatory time after self-admin0.91.53.41.31.01.21.21.01.31.21.11.81.30.5
Bone: tissue strength1.11.12.90.90.81.01.00.91.00.91.11.61.70.2
Total heroin consumption3.84.55.9-2.3-2.4-2.4-2.3-2.4-2.3-2.3-2.1-1.6-1.61.1
Bone: trabecular number0.71.36.50.1-0.5-0.3-0.0-0.80.3-0.60.51.52.02.6
Bone: trabecular spacing0.30.51.9-0.00.30.20.10.4-0.10.4-0.4-1.0-1.4-1.3
Bone: trabecular thickness1.21.65.41.10.70.91.00.61.20.61.51.82.31.2
Bone: trabecular tissue density3.25.69.52.42.92.82.53.12.22.71.80.5-0.3-2.9
Water consumed over 24 hours0.40.81.6-0.8-1.1-0.9-0.8-1.0-0.7-1.0-0.80.30.51.3
Number of responses in last shaping day0.10.20.5-0.4-0.2-0.3-0.3-0.2-0.4-0.4-0.7-0.6-0.7-0.3