Hub : Genes

Cldn14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Cldn14 0.18 0.1 6.7e-04 0.04 0.12 0.16 0.11 3.8e-02 1.1e-03 1.1e-04 1.3e-03
2 Liver gene expression Cldn14 0.05 0.03 1.8e-05 0.05 0.03 0.04 0.04 4.9e-06 4.3e-04 8.6e-05 2.8e-05
3 Liver intron excision ratio chr11_33233296_33241680 0.06 0.04 7.1e-06 0.04 0.04 0.04 0.04 8.2e-06 2.4e-05 1.8e-05 2.8e-05
4 Liver alternative TSS NM_001013429.1 0.16 0.08 0.0e+00 0.15 0.14 0.14 0.14 3.7e-16 3.7e-15 2.2e-15 9.4e-16
5 Liver mRNA stability Cldn14 0.51 0.13 0.0e+00 0.4 0.44 0.46 0.46 7.6e-47 4.3e-54 4.2e-56 2.6e-56
6 Liver intron excision ratio chr11_33233296_33242036 0.17 0.08 5.6e-16 0.12 0.12 0.12 0.12 2.4e-13 6.8e-13 4.8e-13 1.8e-13
7 Liver alternative TSS XM_006248059.3 0.22 0.09 0.0e+00 0.19 0.2 0.21 0.2 5.7e-21 5.9e-22 1.9e-22 3.6e-22
8 pVTA gene expression Cldn14 0.51 0.17 1.5e-12 0.28 0.24 0.28 0.27 2.3e-12 8.4e-11 2.5e-12 2.8e-12
9 Liver isoform ratio NM_001013429.1 0.15 0.08 3.3e-16 0.13 0.13 0.14 0.13 1.2e-14 3.0e-14 1.1e-15 3.3e-14
10 Brain gene expression Cldn14 0.13 0.07 9.2e-09 0.1 0.1 0.1 0.1 1.1e-09 1.7e-09 3.5e-09 6.3e-10
11 NAcc gene expression Cldn14 0.07 0.04 1.1e-04 0.04 0.04 0.04 0.04 1.9e-05 1.4e-05 1.0e-05 1.6e-05
12 Liver isoform ratio XM_006248059.3 0.21 0.09 0.0e+00 0.19 0.2 0.21 0.2 3.9e-21 9.8e-22 1.3e-22 6.0e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.20.80.5-0.1-0.0-0.00.2-0.30.30.9-0.4-0.80.80.3
Area under the delay curve0.10.10.30.10.5-0.0-0.00.4-0.10.00.30.2-0.2-0.4-0.2
BMI with tail0.31.12.01.4-1.00.90.91.41.0-1.0-0.51.10.7-0.9-1.2
BMI without tail0.00.10.20.4-0.1-0.0-0.00.3-0.10.10.4-0.1-0.50.40.0
Body weight0.10.61.31.1-0.70.70.71.10.7-0.7-0.40.70.5-0.6-0.7
Weight adjusted by age1.01.21.6-1.31.2-1.2-1.2-1.0-1.21.20.9-1.1-0.90.61.1
Bone surface3.76.47.22.6-2.72.52.52.52.7-2.7-2.22.62.3-2.4-2.7
Bone volume1.72.94.22.0-1.91.81.82.01.8-1.7-1.11.61.2-1.4-1.7
Breakpoint value in progressive ratio session0.20.30.9-0.60.3-0.3-0.3-0.30.1-0.1-0.80.30.9-0.8-0.2
Number of licking bursts0.91.12.5-0.10.8-0.8-0.8-0.4-1.01.01.6-1.1-1.51.40.9
Context. condit. distance diff. score0.40.51.4-0.90.5-0.3-0.3-0.60.1-0.1-1.10.51.1-1.2-0.4
Locomotion velocity, session 10.00.00.10.0-0.20.20.2-0.10.2-0.2-0.20.10.2-0.1-0.1
Locomotion distance, session 10.91.22.50.1-0.70.80.80.11.1-1.1-1.61.31.6-1.5-1.1
Locomotion velocity, session 20.30.31.0-0.2-0.30.30.3-0.20.5-0.5-1.00.60.9-0.9-0.4
Locomotion distance, session 20.00.00.1-0.10.2-0.1-0.1-0.2-0.0-0.0-0.20.20.2-0.3-0.1
Locomotion velocity, session 35.05.98.41.3-2.52.42.41.12.7-2.6-2.92.62.9-2.6-2.4
Locomotion distance, session 31.01.11.61.3-1.31.21.20.81.1-1.1-0.61.10.6-0.6-1.1
Stereotopy head waving bouts, day 30.40.51.40.9-1.21.11.10.30.6-0.60.40.3-0.40.8-0.2
Stereotopy head waving duration, day 30.30.40.90.7-0.91.01.00.40.6-0.60.20.2-0.20.5-0.2
Locomotion velocity, session 71.21.32.1-1.31.4-1.3-1.3-1.4-1.21.20.8-1.0-0.70.81.0
Locomotion distance, session 71.21.52.5-1.21.5-1.4-1.4-1.6-1.41.31.0-0.9-0.90.90.9
Stereotopy head waving bouts, day 71.21.42.50.3-1.21.31.30.61.4-1.3-1.61.01.5-1.2-0.9
Stereotopy head waving duration, day 72.02.45.30.3-1.31.41.40.71.7-1.6-2.31.42.2-2.0-1.1
Locomotion velocity, session 83.33.95.81.2-2.11.91.91.12.2-2.1-2.42.12.3-2.2-1.8
Locomotion distance, session 80.40.61.8-0.80.5-0.2-0.2-0.50.2-0.3-1.20.61.2-1.3-0.5
Degree of sensitization distance2.02.03.0-1.61.7-1.7-1.7-1.7-1.61.50.8-1.2-0.90.91.3
Degree of sensitization stereotypy2.62.85.40.6-1.31.51.51.11.8-1.8-2.31.52.3-2.2-1.4
Conditioned locomotion0.70.91.2-1.11.1-1.0-1.0-0.9-1.01.00.6-0.9-0.50.70.9
Cocaine response after cond. corrected0.30.30.9-0.80.2-0.4-0.4-0.9-0.00.0-0.80.10.8-0.70.2
Cocaine response after cond. not corrected0.40.51.6-1.10.4-0.7-0.7-1.3-0.30.3-0.8-0.00.7-0.60.3
Cocaine response before conditioning0.00.00.1-0.30.2-0.2-0.2-0.3-0.10.1-0.30.10.2-0.2-0.1
Saline control response0.60.81.80.2-0.60.80.80.21.0-1.0-1.30.91.2-1.2-0.9
Bone: connectivity density0.50.81.51.2-1.11.01.01.10.9-0.8-0.30.80.5-0.4-0.9
Bone: cortical apparent density0.00.00.10.10.1-0.1-0.10.3-0.20.10.3-0.2-0.30.20.1
Bone: cortical area0.20.31.1-0.3-0.2-0.2-0.2-0.20.2-0.3-1.00.31.0-0.9-0.1
Bone: cortical porosity0.50.60.7-0.50.6-0.8-0.8-0.6-0.80.80.8-0.8-0.80.80.8
Bone: cortical porosity0.40.50.6-0.50.6-0.8-0.8-0.5-0.80.80.7-0.7-0.70.60.7
Bone: cortical thickness2.13.55.8-2.41.9-2.4-2.4-2.1-2.01.90.6-1.9-0.60.92.0
Bone: cortical thickness0.81.01.3-1.01.0-1.2-1.2-0.6-1.11.10.8-1.1-0.80.91.0
Bone: cortical tissue density0.00.00.20.20.0-0.0-0.00.4-0.10.10.3-0.1-0.30.2-0.0
Condit. Reinf. active minus inactive responses0.00.00.0-0.20.1-0.1-0.1-0.0-0.10.1-0.0-0.10.1-0.00.1
Condit. Reinf. active-inactive response ratio0.30.30.8-0.90.8-0.6-0.6-0.7-0.50.50.1-0.6-0.10.20.6
Condit. Reinf. active responses0.00.10.2-0.1-0.10.10.10.10.1-0.1-0.30.20.4-0.4-0.1
Condit. Reinf. inactive responses0.20.20.50.3-0.70.40.40.20.5-0.5-0.40.50.5-0.4-0.4
Incentive salience index mean0.10.10.2-0.50.4-0.4-0.4-0.3-0.40.40.1-0.4-0.00.00.3
Condit. Reinf. lever presses0.30.41.1-1.00.9-0.8-0.8-0.7-0.70.70.1-0.6-0.00.00.6
Condit. Reinf. active minus inactive responses0.91.13.20.2-0.50.50.50.40.9-0.9-1.61.11.6-1.8-1.0
Condit. Reinf. active-inactive response ratio0.10.10.40.3-0.10.10.10.50.2-0.2-0.30.40.3-0.7-0.4
Condit. Reinf. active responses1.42.04.50.4-1.01.01.00.41.4-1.4-2.11.52.1-2.0-1.3
Condit. Reinf. inactive responses1.11.43.30.2-0.91.01.0-0.01.3-1.3-1.81.21.7-1.4-1.0
Condit. Reinf. lever presses0.60.81.90.2-0.40.60.60.50.9-0.9-1.40.91.4-1.3-0.9
Condit. Reinf. lever reinforcers received1.72.35.10.5-1.11.11.10.51.5-1.5-2.31.62.2-2.2-1.4
Conditioned reinforcement - actives0.60.61.9-0.71.0-1.4-1.4-0.4-0.70.6-0.3-0.70.3-0.20.6
Conditioned reinforcement - inactives2.32.55.9-2.42.2-1.9-1.9-2.0-1.51.50.1-1.4-0.20.41.4
Conditioned locomotion0.30.30.7-0.90.8-0.4-0.4-0.6-0.50.50.2-0.7-0.40.40.6
Patch foraging indifference point 0 sec1.62.66.4-2.51.9-1.8-1.8-2.2-1.51.50.2-1.5-0.20.61.7
Patch foraging indifference point AUC2.12.44.70.5-1.61.31.30.51.7-1.5-2.21.62.0-1.9-1.3
Delay disc. indifference point, 0s delay0.20.20.80.50.00.30.30.90.3-0.3-0.20.50.4-0.7-0.6
Delay disc. indifference point, 16s delay0.20.20.60.40.20.20.20.4-0.10.10.8-0.0-0.70.4-0.0
Delay disc. indifference point, 2s delay0.10.10.90.7-0.1-0.1-0.10.9-0.0-0.10.10.1-0.1-0.3-0.3
Delay disc. indifference point, 24s delay0.40.41.3-0.71.1-0.7-0.7-0.5-0.80.70.5-0.4-0.60.30.5
Delay disc. indifference point, 4s delay0.20.20.50.6-0.40.40.40.70.3-0.4-0.10.60.2-0.7-0.5
Delay disc. indifference point, 8s delay0.20.21.2-0.61.1-0.2-0.2-0.3-0.40.40.4-0.3-0.3-0.20.3
Indifference point function ln k1.41.92.8-1.61.7-1.5-1.5-1.1-1.51.41.1-1.5-1.11.01.4
Indifference point function log k1.41.92.8-1.61.7-1.5-1.5-1.1-1.51.41.1-1.5-1.11.01.4
Patch foraging total patch changes 0 sec1.11.85.0-2.21.6-1.5-1.5-1.9-1.21.1-0.1-1.10.10.21.3
Patch foraging total patch changes 12 sec0.81.12.50.0-0.80.90.90.11.2-1.0-1.61.01.5-1.3-0.7
Patch foraging total patch changes 18 sec0.70.93.7-0.5-0.60.20.2-0.20.8-0.6-1.90.61.7-1.3-0.5
Patch foraging total patch changes 24 sec0.91.13.3-0.1-0.50.50.50.40.9-0.9-1.81.01.7-1.7-0.8
Patch foraging total patch changes 6 sec0.40.62.5-0.8-0.1-0.0-0.0-0.90.5-0.4-1.60.31.4-0.8-0.0
Patch foraging time to switch 0 sec0.10.20.70.80.00.20.20.5-0.10.00.80.1-0.70.6-0.2
Patch foraging water rate 0 sec0.71.12.10.1-0.81.11.10.71.2-1.2-1.50.81.4-1.2-0.8
Patch foraging water rate 12 sec1.92.86.1-2.52.0-2.1-2.1-1.9-1.71.60.5-1.5-0.50.71.5
Patch foraging water rate 18 sec0.20.31.30.5-0.20.60.61.10.5-0.5-0.10.30.0-0.2-0.6
Patch foraging water rate 24 sec0.40.61.9-1.41.0-1.1-1.1-0.6-0.60.6-0.2-0.40.2-0.40.4
Patch foraging water rate 6 sec0.10.20.7-0.90.5-0.3-0.3-0.3-0.20.2-0.4-0.20.3-0.40.2
Seeking ratio, delayed vs. immediate footshock0.91.03.30.50.4-0.3-0.30.3-0.70.81.6-1.0-1.81.70.7
Distance traveled before self-admin0.20.20.6-0.1-0.10.20.20.30.4-0.4-0.80.50.7-0.8-0.4
Distance traveled after self-admin0.30.40.90.9-0.30.70.71.00.2-0.20.80.3-0.70.4-0.5
Extensor digitorum longus weight3.915.521.74.7-4.44.54.54.44.3-4.2-2.53.82.5-2.7-3.9
Bone: elastic displacement0.60.61.3-0.20.3-0.7-0.7-0.4-0.80.81.1-0.8-1.11.10.8
Bone: elastic work0.00.00.1-0.0-0.2-0.2-0.2-0.0-0.20.20.2-0.2-0.20.30.3
Bone: endosteal estimation4.18.911.83.4-3.13.33.33.23.2-3.1-2.03.22.0-2.4-3.3
Bone: endosteal perimeter2.55.37.01.9-2.22.12.11.62.4-2.4-2.52.62.4-2.6-2.5
Epididymis fat weight4.610.612.03.4-3.13.13.13.53.4-3.4-3.03.43.1-3.4-3.4
Delta time in closed arm before/after self-admin0.20.20.70.7-0.00.40.40.5-0.00.10.9-0.1-0.70.6-0.0
Delta time in open arm before/after self-admin0.30.30.50.5-0.50.50.50.70.7-0.6-0.60.40.5-0.5-0.6
Diff in mean of infusions in LGA sessions1.51.75.8-0.6-0.30.70.7-0.11.0-1.0-2.41.12.4-2.0-0.9
Delay discount exponential model param0.10.10.2-0.0-0.50.10.1-0.30.1-0.1-0.3-0.10.20.40.1
Extinction: sum of active levers before priming0.90.93.1-0.70.10.10.1-0.10.7-0.7-1.70.61.8-1.5-0.6
Active lever presses in extinction session 60.40.42.0-1.10.4-0.4-0.4-1.4-0.30.30.0-0.40.20.60.7
Bone: final force0.50.81.10.7-1.00.80.80.70.9-0.9-1.01.01.0-1.0-0.8
Bone: final moment0.50.81.20.6-0.90.70.70.60.9-0.9-1.10.91.1-1.1-0.8
Food consumed during 24 hour testing period0.50.71.4-1.21.0-0.9-0.9-1.1-0.80.80.2-0.7-0.30.40.8
Glucose4.26.47.81.9-2.42.72.71.92.8-2.8-2.62.62.7-2.6-2.5
Heart weight0.81.24.12.0-0.71.01.02.00.5-0.61.10.3-1.00.6-0.6
Delay discount hyperbolic model param0.10.10.3-0.3-0.30.00.0-0.60.10.0-0.3-0.20.20.30.2
Intermittent access intake day 1-15 change0.80.82.3-1.51.0-0.7-0.7-1.3-0.80.90.3-0.8-0.30.50.9
Intermittent access intake escalation0.80.82.2-1.51.0-0.7-0.7-1.3-0.80.90.3-0.8-0.30.50.9
Intermittent access intake escalation 20.50.52.0-1.40.5-0.6-0.6-1.4-0.20.3-0.7-0.30.7-0.30.5
Intermitt. access day 1 inactive lever presses2.12.35.0-2.11.9-1.4-1.4-2.2-1.41.41.0-1.3-1.01.01.4
Intermitt. access day 15 inactive lever presses1.01.13.3-1.81.3-1.4-1.4-1.3-0.80.7-0.7-0.50.7-0.50.6
Intermitt. access escalation Index0.20.20.3-0.50.3-0.4-0.4-0.2-0.50.50.3-0.5-0.20.30.6
Intermittent access day 1 total infusions1.01.22.9-1.61.3-1.7-1.7-0.9-1.00.9-0.5-0.90.3-0.20.8
Intermittent access day 15 total infusions2.73.18.4-2.92.1-2.0-2.0-2.4-1.61.6-0.1-1.5-0.10.51.6
Intermittent access terminal intake (last 3 days)2.52.77.1-2.72.0-2.0-2.0-2.2-1.51.50.1-1.5-0.10.41.5
Intermittent access total infusions2.12.35.5-2.31.7-2.0-2.0-1.9-1.41.3-0.2-1.30.10.21.4
Intermittent access day 1 locomotion2.02.14.4-2.11.9-1.7-1.7-1.6-1.41.50.2-1.4-0.40.31.4
Intermittent access day 15 total locomotion1.01.14.1-2.01.3-1.0-1.0-1.6-0.50.6-1.0-0.40.9-0.70.5
Intermittent access total locomotion2.22.58.3-2.92.0-1.7-1.7-2.4-1.11.2-0.9-0.90.7-0.61.2
Intermittent access standard deviation0.40.41.9-1.20.6-0.3-0.3-1.4-0.40.50.0-0.5-0.20.40.7
Left kidney weight1.44.17.1-1.72.5-2.7-2.7-1.2-2.42.11.7-1.9-1.61.21.8
Right kidney weight1.44.06.3-2.12.5-2.4-2.4-1.9-2.22.21.5-1.8-1.51.11.8
Cocaine induced anxiety0.10.10.4-0.5-0.1-0.2-0.2-0.40.1-0.0-0.60.10.6-0.40.0
Post-drug Anxiety1.21.43.4-0.1-0.90.80.8-0.11.1-1.0-1.81.31.8-1.6-1.0
Baseline Anxiety0.10.10.20.2-0.30.40.4-0.10.3-0.3-0.30.40.3-0.2-0.3
Tail length0.51.52.8-1.71.1-1.3-1.3-1.6-1.21.20.4-1.2-0.60.71.4
Length with tail0.10.30.6-0.70.5-0.5-0.5-0.5-0.50.50.4-0.7-0.50.40.8
Length without tail0.00.10.20.1-0.10.20.20.10.2-0.2-0.30.10.4-0.4-0.1
Times rat made contact with spout8.29.512.8-3.63.5-3.2-3.2-3.5-3.33.22.2-3.1-2.22.53.1
Lifetime Intake1.11.22.6-1.41.2-1.6-1.6-1.1-1.11.0-0.0-1.1-0.10.41.1
Liver weight, left0.30.51.2-0.90.8-1.1-1.1-0.4-0.80.70.0-0.8-0.2-0.00.8
Liver weight, right0.00.10.2-0.00.2-0.2-0.2-0.2-0.30.20.4-0.1-0.50.30.1
Locomotor activity2.43.85.6-2.32.4-2.1-2.1-2.4-2.12.11.4-1.6-1.41.11.8
Locomotor testing distance1.32.14.0-2.01.7-1.5-1.5-2.0-1.51.50.8-1.3-0.90.91.4
Locomotor testing rearing0.60.91.7-1.21.3-1.0-1.0-0.9-1.11.00.6-0.8-0.60.40.8
Locomotion in novel chamber0.30.31.3-1.10.9-0.6-0.6-0.7-0.50.40.0-0.4-0.00.10.3
Locomotion in novel chamber post-restriction0.91.13.01.7-1.31.21.21.70.8-0.80.10.7-0.0-0.0-0.9
Fecal boli incidents, locomotor time 10.30.31.1-0.81.1-0.9-0.9-0.1-0.30.3-0.3-0.00.3-0.4-0.0
Change in fecal boli incidents, locomotor task1.71.62.3-1.41.2-0.9-0.9-1.5-1.41.41.4-1.3-1.31.11.4
Time >=10cm from walls, locomotor time 10.50.61.7-1.30.9-0.4-0.4-0.9-0.60.70.1-0.9-0.20.31.0
Bouts of movement, locomotor time 10.10.10.3-0.1-0.20.50.50.20.3-0.3-0.30.50.4-0.3-0.5
Total resting periods, locomotor time 10.20.20.4-0.2-0.10.60.60.00.4-0.3-0.50.60.6-0.5-0.5
Rest time, locomotor task time 11.31.42.70.7-0.81.41.40.81.3-1.1-0.71.60.9-1.4-1.6
Distance moved, locomotor task time 11.51.73.8-0.10.6-0.8-0.8-0.5-1.31.11.6-1.8-1.72.01.6
Vertical activity count, locomotor time 10.40.40.9-0.00.2-0.8-0.8-0.2-0.70.50.2-0.9-0.30.80.9
Time >=10cm from walls, locomotor time 20.60.71.71.1-0.91.31.30.90.8-0.70.30.3-0.30.2-0.4
Bouts of movement, locomotor time 22.52.76.20.8-1.11.21.21.31.4-1.5-2.21.72.3-2.5-1.5
Total resting periods, locomotor time 21.31.44.20.2-0.50.70.70.60.9-0.9-1.81.31.8-2.1-1.0
Rest time, locomotor task time 20.40.51.5-1.20.2-0.1-0.1-1.10.10.1-0.80.50.9-1.0-0.2
Distance moved, locomotor task time 20.81.02.61.6-0.60.70.71.2-0.0-0.11.4-0.6-1.41.40.1
Vertical activity count, locomotor time 20.50.62.21.5-0.80.60.61.50.3-0.40.5-0.0-0.50.5-0.3
Light reinforcement 10.10.20.50.7-0.40.30.30.60.3-0.30.00.5-0.1-0.3-0.5
Light reinforcement 24.96.57.72.5-2.62.62.62.42.7-2.6-2.32.82.3-2.6-2.6
Bone: marrow area4.29.211.73.4-3.13.33.33.23.2-3.2-2.13.22.2-2.5-3.3
Bone: maximum diameter1.12.13.90.8-1.21.11.10.91.5-1.5-2.01.51.9-1.9-1.4
Bone: maximum force0.40.71.10.9-1.00.90.90.80.9-0.9-0.70.80.7-0.7-0.8
Bone: maximum moment0.40.60.80.8-0.90.80.80.80.8-0.8-0.70.80.7-0.7-0.7
Mean time between licks in bursts2.12.93.7-1.41.6-1.6-1.6-1.8-1.71.71.9-1.6-1.81.91.6
Mean num. licks in bursts0.70.83.0-1.71.0-0.8-0.8-1.5-0.60.6-0.4-0.50.4-0.10.7
Cd content in liver1.71.93.1-1.01.0-1.2-1.2-1.4-1.41.41.5-1.4-1.51.81.5
Co content in liver0.00.00.10.10.10.10.10.40.0-0.10.10.0-0.1-0.1-0.1
Cu content in liver0.00.00.0-0.00.00.10.10.1-0.00.00.1-0.2-0.10.20.1
Fe content in liver0.10.10.30.0-0.20.40.40.10.2-0.10.2-0.4-0.20.60.3
K content in liver0.50.51.31.1-0.60.90.91.10.6-0.60.10.5-0.0-0.0-0.7
Mg content in liver0.40.41.21.0-0.60.90.91.10.6-0.60.10.3-0.20.2-0.5
Mn content in liver1.31.51.91.2-1.21.21.21.31.2-1.2-1.01.31.0-1.3-1.4
Na content in liver3.84.05.01.4-2.02.02.01.52.2-2.1-2.22.02.2-2.1-2.0
Rb content in liver1.01.21.7-0.71.2-1.1-1.1-0.3-1.21.11.2-1.3-1.31.11.1
Se content in liver0.60.71.9-0.60.5-0.3-0.3-0.8-0.70.71.0-1.0-0.91.41.0
Sr content in liver2.11.92.7-1.51.6-1.5-1.5-1.4-1.51.51.1-1.3-1.21.11.3
Zn content in liver0.40.41.5-1.20.9-0.5-0.5-1.0-0.40.4-0.2-0.50.10.10.5
Bone: minimum diameter4.58.39.92.9-3.12.92.92.53.1-3.1-2.73.02.7-2.7-2.9
Time in familiar zone, hab. session 10.10.10.5-0.30.2-0.1-0.1-0.10.2-0.2-0.60.40.5-0.7-0.3
Time in novel zone, hab. session 10.70.72.31.5-1.10.90.91.00.4-0.40.70.2-0.70.8-0.3
Total zone transitions, hab. session 10.91.22.7-1.51.2-1.4-1.4-1.7-1.21.10.2-0.7-0.20.20.9
Total locomotion distance, hab. session 11.21.72.6-1.41.4-1.6-1.6-1.6-1.51.50.8-1.1-0.80.91.2
Locomotion velocity, hab. session 11.31.92.7-1.51.4-1.7-1.7-1.7-1.51.50.9-1.2-0.91.01.3
Time in familiar zone, hab. session 20.80.81.60.7-0.60.70.70.90.9-0.9-1.01.10.9-1.3-1.1
Time in novel zone, hab. session 20.60.61.6-0.20.4-0.5-0.5-0.5-0.70.71.1-1.0-1.11.30.9
Total zone transitions, hab. session 20.30.41.2-0.90.9-0.8-0.8-1.1-0.60.5-0.3-0.00.3-0.50.2
Total locomotion distance, hab. session 21.41.83.0-1.31.6-1.7-1.7-1.5-1.61.50.9-1.0-0.90.71.1
Locomotion velocity, hab. session 21.31.72.8-1.31.6-1.7-1.7-1.5-1.51.50.9-1.0-0.90.71.0
Novel to familiar place preference ratio0.30.31.20.6-0.10.10.1-0.0-0.30.31.0-0.3-1.11.10.2
Novelty place preference0.40.41.01.0-0.40.40.40.5-0.10.01.0-0.1-1.01.0-0.1
Time in novel zone, NPP test0.40.41.31.2-0.60.60.60.70.1-0.10.80.1-0.80.8-0.3
Total zone transitions, NPP test0.20.31.1-0.70.3-0.2-0.2-0.50.1-0.1-1.00.31.0-1.0-0.2
Total locomotion distance, NPP test0.20.20.3-0.40.6-0.6-0.6-0.5-0.60.50.4-0.3-0.50.40.3
Locomotion velocity, NPP test0.30.50.7-0.60.8-0.8-0.8-0.7-0.80.80.6-0.6-0.60.50.5
Intraocular pressure0.30.51.01.0-0.40.70.71.00.1-0.11.0-0.1-0.91.0-0.1
Delta distance traveled before/after self-admin0.30.41.40.60.10.00.00.5-0.40.41.2-0.2-1.10.90.0
Delta ambulatory time before/after self-admin0.30.31.20.6-0.0-0.1-0.10.3-0.40.41.1-0.1-1.00.7-0.0
Parametrial fat weight1.63.15.12.3-1.72.02.02.11.8-1.8-0.71.90.8-1.2-1.9
Pavlov. Cond. lever latency0.00.10.30.3-0.0-0.1-0.10.0-0.10.10.50.1-0.50.4-0.0
Pavlov. Cond. magazine entry latency0.70.81.2-0.71.0-0.8-0.8-0.6-1.00.91.0-1.1-1.01.01.0
Pavlov. Cond. change in total contacts0.10.10.3-0.50.6-0.4-0.4-0.2-0.40.40.0-0.40.0-0.10.4
Pavlov. Cond. index score0.10.20.3-0.50.5-0.4-0.4-0.4-0.40.40.2-0.6-0.20.30.5
Pavlov. Cond. latency score0.20.30.5-0.60.6-0.5-0.5-0.4-0.50.50.3-0.7-0.30.40.6
Pavlov. Cond. lever contacts0.20.20.8-0.90.5-0.4-0.4-0.6-0.20.2-0.6-0.30.6-0.40.3
Pavlov. Cond. magazine entry number0.20.30.50.3-0.60.30.30.10.5-0.5-0.70.70.7-0.7-0.5
Pavlov. Cond. intertrial magazine entries3.44.15.51.4-2.32.32.31.72.4-2.2-2.01.82.0-1.7-1.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.50.5-0.3-0.3-0.3-0.40.40.2-0.5-0.20.20.5
Pavlov. Cond. response bias0.30.40.8-0.90.8-0.6-0.6-0.6-0.60.60.2-0.8-0.20.30.7
Pavlov. Cond. lever latency1.82.44.7-0.61.1-1.2-1.2-1.0-1.61.62.1-1.6-2.22.11.5
Pavlov. Cond. magazine entry latency0.20.20.7-0.70.4-0.3-0.3-0.40.0-0.0-0.80.20.8-0.8-0.1
Pavlov. Cond. change in total contacts0.91.32.70.6-0.70.80.81.01.1-1.1-1.41.21.5-1.7-1.2
Pavlov. Cond. index score0.50.72.2-0.5-0.10.20.2-0.10.6-0.6-1.50.71.5-1.4-0.6
Pavlov. Cond. latency score0.30.41.2-0.70.3-0.1-0.1-0.30.2-0.2-1.10.41.1-1.0-0.3
Pavlov. Cond. lever contacts0.91.22.60.4-0.70.80.80.81.1-1.1-1.61.11.6-1.6-1.1
Pavlov. Cond. magazine entry number0.20.30.7-0.10.1-0.2-0.2-0.3-0.40.40.7-0.6-0.80.80.6
Pavlov. Cond. intertrial magazine entries0.20.30.50.3-0.70.60.60.10.6-0.6-0.70.40.5-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.50.62.1-0.6-0.00.10.1-0.10.5-0.5-1.50.61.4-1.4-0.5
Pavlov. Cond. response bias0.81.12.60.2-0.60.70.70.51.0-1.0-1.51.11.6-1.6-1.0
Time in closed arm before self-admin0.50.61.00.9-0.90.50.50.90.8-0.8-0.61.00.6-0.9-0.9
Time in closed arm after self-admin0.90.93.51.9-0.70.70.71.60.4-0.50.90.7-0.80.1-0.9
Time in open arm before self-admin0.10.20.4-0.50.7-0.3-0.3-0.4-0.40.40.2-0.3-0.30.40.3
Time in open arm after self-admin0.50.52.1-0.5-0.10.20.2-0.20.6-0.5-1.40.41.4-0.9-0.4
Bone: periosteal estimation1.73.64.21.9-2.01.81.81.82.0-2.0-1.82.01.8-1.9-2.0
Bone: periosteal perimeter1.11.83.80.5-1.10.80.80.51.3-1.3-2.01.51.9-1.8-1.3
Bone: post-yield work0.81.11.60.5-1.01.11.10.81.2-1.2-1.20.91.1-1.0-0.9
Progressive ratio test 1 active lever presses0.91.01.9-1.01.2-1.4-1.4-0.4-1.11.10.5-1.1-0.60.50.9
Progressive ratio test 1 breakpoint1.21.31.9-1.11.3-1.4-1.4-0.6-1.31.20.8-1.3-0.90.81.0
Progressive ratio test 1 inactive lever presses1.01.11.4-1.11.0-1.1-1.1-1.2-1.11.10.7-1.1-0.70.81.2
Progressive ratio test 2 active lever presses1.61.73.6-1.91.4-1.7-1.7-1.7-1.21.2-0.1-1.20.00.41.3
Progressive ratio test 2 breakpoint1.41.53.2-1.81.2-1.6-1.6-1.7-1.21.20.1-1.2-0.10.51.3
Progressive ratio test 2 inactive lever presses2.42.87.8-2.81.7-2.1-2.1-2.3-1.31.3-1.0-1.10.9-0.51.4
Incentive Sensitization - Responses0.40.51.3-0.80.1-0.8-0.8-0.8-0.10.0-1.1-0.11.1-0.60.2
Incentive Sensitization - Breakpoint0.50.51.3-1.00.2-0.8-0.8-1.0-0.10.1-1.0-0.21.1-0.60.3
Sum of active levers in priming session hrs 5-60.20.20.6-0.70.20.30.3-0.60.4-0.3-0.8-0.00.7-0.30.1
Progressive ratio0.00.10.20.3-0.40.40.40.10.2-0.1-0.10.20.1-0.1-0.0
Food seeking constrained by brief footshock1.82.22.7-1.21.1-1.5-1.5-1.5-1.61.51.6-1.6-1.41.51.6
Seeking ratio, punishment vs. effort1.21.52.1-0.91.1-1.3-1.3-0.9-1.31.21.4-1.2-1.31.31.0
Retroperitoneal fat weight1.96.38.52.8-2.62.92.92.72.7-2.6-1.72.51.8-1.9-2.6
Reaction time number correct0.10.20.6-0.1-0.4-0.1-0.1-0.10.2-0.2-0.80.20.8-0.60.0
Reaction time mean minus median0.20.31.2-1.10.4-0.3-0.3-0.9-0.40.50.0-0.4-0.0-0.00.7
Reaction time mean minus median AUC0.20.30.8-0.9-0.10.20.2-0.50.3-0.2-0.90.30.8-0.90.1
Reaction time num false alarms2.73.74.9-1.41.7-1.8-1.8-1.9-2.12.02.2-1.8-2.12.22.0
Reaction time num false alarms AUC2.94.05.4-1.41.9-1.8-1.8-1.9-2.22.12.3-1.9-2.32.22.0
Reaction time trials correct on left0.10.20.6-0.1-0.4-0.1-0.1-0.10.2-0.2-0.80.20.8-0.60.0
Reaction time trials on left0.10.20.7-0.1-0.5-0.1-0.1-0.10.3-0.3-0.80.20.8-0.60.0
Reaction time mean0.20.30.60.7-0.60.80.80.70.3-0.20.70.1-0.70.5-0.2
Reaction time mean AUC0.10.10.40.3-0.50.60.60.30.3-0.10.40.1-0.40.3-0.1
Median of all reaction times0.50.71.81.3-0.91.01.01.30.5-0.40.90.3-0.80.6-0.5
Reaction time omissions0.20.30.60.4-0.60.80.80.20.6-0.5-0.40.70.4-0.6-0.5
Reaction time false alarm rate2.83.96.4-1.31.9-1.6-1.6-1.7-2.12.02.5-1.9-2.52.31.9
Reaction time premature initiation rate0.81.12.31.0-1.00.90.91.51.1-1.1-0.90.90.8-1.2-1.1
Reaction time premature initiations0.81.22.20.7-1.10.80.81.11.1-1.1-1.31.01.3-1.5-0.9
Std. dev. reaction times0.20.30.8-0.80.4-0.2-0.2-0.9-0.40.50.6-0.5-0.60.50.7
Reaction time trials completed0.10.20.7-0.1-0.5-0.1-0.1-0.10.3-0.3-0.80.20.8-0.60.0
Reaction time trials AUC0.20.30.90.1-0.70.20.20.20.5-0.5-0.90.40.9-0.7-0.2
Run reversals in cocaine runway, females0.60.51.1-0.80.8-1.1-1.1-0.4-1.00.90.3-0.7-0.40.20.6
Run reversals in cocaine runway, males0.30.31.0-0.5-0.1-0.3-0.3-0.50.1-0.2-1.00.21.0-0.90.0
Latency to leave start box in cocaine runway0.10.10.50.5-0.30.30.30.20.00.00.7-0.1-0.60.30.2
Latency to leave start box in cocaine runway, F0.60.72.90.7-0.20.10.10.0-0.40.51.7-0.5-1.51.20.5
Latency to leave start box in cocaine runway, M0.80.71.20.3-0.50.80.80.51.0-0.9-1.10.91.0-1.1-0.8
Std. dev. time between licks in bursts0.50.62.0-1.40.7-0.8-0.8-1.2-0.60.6-0.1-0.60.10.10.7
Total sessions with >9 infusions1.11.22.1-0.51.2-0.9-0.9-0.4-1.21.21.3-1.3-1.41.31.1
Short access day 1 total inactive lever presses1.92.14.3-2.12.1-1.3-1.3-1.9-1.41.30.8-1.3-0.81.01.3
Short access day 10 total inactive lever presses0.40.51.40.6-0.61.21.20.00.8-0.7-0.10.70.00.1-0.6
Short access day 1 total infusions0.50.61.30.00.3-0.5-0.50.0-0.70.71.0-1.0-1.11.20.8
Short access day 10 total infusions0.40.51.30.10.6-0.5-0.50.4-0.60.50.9-0.9-1.11.00.5
Short access total infusions0.40.40.70.10.3-0.7-0.70.3-0.60.50.7-0.8-0.90.70.6
Short access day 1 locomotion1.41.53.5-0.71.4-0.5-0.5-0.7-1.11.11.8-1.4-1.91.71.0
Short access day 10 total locomotion0.10.10.4-0.40.7-0.2-0.2-0.1-0.30.20.0-0.3-0.3-0.00.2
Short access total locomotion0.20.20.6-0.20.70.00.00.0-0.20.20.6-0.4-0.80.40.2
One hour access (0.3 mA shock)1.21.33.0-1.71.5-1.5-1.5-1.5-0.80.7-0.9-0.61.0-0.50.7
Compulsive drug intake1.61.63.40.9-0.90.90.91.01.2-1.2-1.51.41.7-1.9-1.3
One hour access (shock baseline)1.61.94.9-2.21.6-1.7-1.7-2.0-1.21.1-0.3-1.20.20.31.3
Social response proportion1.01.11.6-1.21.2-0.9-0.9-0.7-1.11.11.0-1.3-1.10.71.2
Social responses0.70.91.8-1.21.3-0.9-0.9-0.7-1.01.00.8-1.1-0.90.51.0
Social time0.10.10.4-0.30.30.20.20.30.3-0.3-0.50.20.5-0.6-0.3
Soleus weight1.03.14.11.4-1.61.61.61.61.8-1.8-1.91.91.9-2.0-1.8
Bone: stiffness0.00.00.0-0.10.1-0.1-0.1-0.1-0.10.0-0.1-0.00.1-0.10.1
Tibialis anterior weight7.024.034.75.9-5.65.65.65.55.3-5.2-3.04.73.1-3.3-4.8
Time to tail flick, vehicle, before self-admin5.35.59.5-1.62.1-1.9-1.9-1.9-2.32.22.8-2.6-2.83.12.4
Time to tail flick, vehicle, after self-admin2.22.43.11.6-1.51.71.71.81.7-1.6-1.01.61.0-1.3-1.6
Time to tail flick, test, before self-admin0.60.61.9-0.10.6-0.5-0.5-0.4-0.80.71.4-0.6-1.20.90.6
Time to tail flick, test, after self-admin0.30.30.9-0.20.7-0.5-0.5-0.0-0.70.61.0-0.5-0.80.30.4
Delta time to tail flick, vehicle, before/after SA5.95.88.21.9-2.32.22.22.32.5-2.4-2.62.72.5-2.9-2.6
Delta time to tail flick, test, before/after SA0.00.00.1-0.10.1-0.0-0.00.10.1-0.0-0.2-0.00.2-0.3-0.0
Tibia length0.00.00.00.10.10.10.10.2-0.00.00.2-0.0-0.10.00.0
Ambulatory time before self-admin0.80.91.70.4-0.70.70.70.61.0-1.0-1.20.91.3-1.2-0.9
Ambulatory time after self-admin0.50.61.01.0-0.80.90.91.00.7-0.70.10.80.0-0.2-1.0
Bone: tissue strength0.40.40.5-0.60.7-0.6-0.6-0.6-0.70.70.6-0.6-0.70.50.6
Total heroin consumption1.92.27.0-2.62.1-1.6-1.6-1.8-1.21.3-0.6-1.10.7-0.61.2
Bone: trabecular number0.10.10.30.4-0.1-0.0-0.00.3-0.20.20.6-0.2-0.40.40.1
Bone: trabecular spacing2.33.05.0-2.02.2-1.9-1.9-1.6-1.91.81.2-1.8-1.31.11.7
Bone: trabecular thickness0.50.61.21.0-1.11.01.01.00.8-0.7-0.30.60.3-0.3-0.7
Bone: trabecular tissue density0.91.32.1-1.11.5-1.4-1.4-1.1-1.31.30.9-1.0-1.00.81.0
Water consumed over 24 hours0.40.51.3-1.10.9-0.8-0.8-0.9-0.60.6-0.1-0.40.1-0.10.5
Number of responses in last shaping day1.01.13.1-0.61.0-0.4-0.4-0.3-0.81.01.8-1.0-1.71.40.7