Hub : Genes

Cldn14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr11_46702955_46711339 0.06 0.04 4.7e-06 0.05 0.04 0.04 0.04 7.6e-06 1.6e-05 1.5e-05 2.0e-05
2 Liver isoform ratio NM_001013429.1 0.18 0.08 0.0e+00 0.16 0.17 0.16 0.17 7.0e-17 5.3e-18 6.1e-18 3.9e-18
3 Liver alternative TSS NM_001013429.1 0.17 0.08 0.0e+00 0.15 0.15 0.16 0.16 4.4e-16 1.6e-16 3.2e-17 5.5e-17
4 Liver gene expression Cldn14 0.05 0.03 4.3e-06 0.04 0.03 0.03 0.04 1.1e-05 1.1e-04 1.5e-04 4.5e-05
5 Liver intron excision ratio chr11_46702955_46711695 0.17 0.08 5.6e-16 0.12 0.12 0.12 0.12 4.1e-13 4.3e-13 1.3e-13 8.7e-14
6 Liver mRNA stability Cldn14 0.5 0.13 0.0e+00 0.4 0.45 0.46 0.46 1.3e-46 2.0e-54 7.0e-56 1.9e-56
7 Liver alternative TSS XM_006248059.4 0.22 0.09 0.0e+00 0.19 0.21 0.21 0.21 7.9e-21 2.5e-23 1.1e-22 1.1e-22
8 Liver isoform ratio XM_006248059.4 0.23 0.09 0.0e+00 0.2 0.22 0.2 0.22 3.2e-21 2.6e-24 2.6e-22 3.6e-24
9 Brain alternative TSS XM_039088410.2 0.03 0.02 4.3e-03 0.01 0.01 0 0 4.7e-02 1.3e-02 2.0e-01 1.4e-01
10 LHb gene expression Cldn14 0.18 0.1 6.1e-04 0.07 0.12 0.11 0.13 1.0e-02 1.0e-03 1.5e-03 5.7e-04
11 Brain gene expression Cldn14 0.12 0.06 9.6e-09 0.11 0.09 0.08 0.1 4.2e-10 2.7e-08 1.4e-07 2.6e-09
12 NAcc gene expression Cldn14 0.1 0.07 2.3e-06 0.05 0.02 0.02 0.03 1.3e-07 2.6e-04 5.2e-04 5.3e-05
13 pVTA gene expression Cldn14 0.38 0.13 0.0e+00 0.26 0.27 0.26 0.26 6.9e-21 1.7e-21 1.5e-20 4.1e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.30.9-0.6-0.4-0.30.70.30.60.20.20.6-0.9-0.5-0.7-0.7
Area under the delay curve0.10.10.20.00.20.3-0.2-0.30.2-0.2-0.2-0.40.3-0.5-0.4-0.1
BMI with tail0.31.22.4-1.2-1.1-1.11.41.01.41.11.11.3-1.60.2-0.30.0
BMI without tail0.10.31.3-0.2-0.1-0.20.30.10.4-0.0-0.10.3-0.8-0.8-1.1-0.8
Body weight0.00.00.10.10.10.20.2-0.2-0.0-0.1-0.1-0.20.1-0.2-0.30.0
Weight adjusted by age0.81.21.81.31.21.1-1.0-1.1-1.3-1.2-1.2-1.31.3-0.8-0.9-0.4
Bone surface4.47.910.0-3.0-3.2-3.03.13.02.93.13.12.5-2.12.72.32.2
Bone volume2.44.35.7-2.3-2.3-2.22.32.22.42.32.32.0-1.81.71.51.3
Breakpoint value in progressive ratio session0.40.41.6-0.3-0.4-0.60.30.60.20.60.60.10.21.31.11.1
Number of licking bursts0.61.02.70.71.00.9-0.8-1.0-0.3-0.8-0.9-0.2-0.2-1.5-1.6-1.4
Context. condit. distance diff. score0.60.72.20.60.30.0-0.70.1-0.6-0.00.0-1.01.51.11.11.5
Locomotion velocity, session 10.00.00.2-0.3-0.2-0.40.10.4-0.00.10.10.2-0.20.1-0.1-0.1
Locomotion distance, session 10.81.02.4-0.9-1.0-1.20.51.30.20.80.90.10.11.51.11.4
Locomotion velocity, session 20.20.30.9-0.3-0.4-0.30.30.4-0.20.30.3-0.20.40.90.80.9
Locomotion distance, session 20.00.00.1-0.2-0.10.0-0.30.1-0.1-0.00.0-0.40.20.2-0.00.4
Locomotion velocity, session 34.45.17.6-2.1-2.5-2.72.32.61.32.32.31.7-0.72.82.72.2
Locomotion distance, session 30.80.91.5-1.1-1.1-1.21.01.20.91.01.01.1-1.00.50.30.1
Stereotopy head waving bouts, day 31.01.23.4-1.2-1.1-1.11.61.00.60.60.51.6-1.8-0.2-0.1-1.0
Stereotopy head waving duration, day 30.70.82.0-1.0-1.0-1.01.30.90.70.60.61.4-1.4-0.00.2-0.6
Locomotion velocity, session 71.21.31.91.31.31.2-1.3-1.1-1.4-1.3-1.3-1.21.0-0.8-0.9-0.6
Locomotion distance, session 71.51.92.81.41.41.4-1.5-1.3-1.6-1.5-1.5-1.71.0-1.0-1.5-0.7
Stereotopy head waving bouts, day 72.02.34.0-1.2-1.6-1.71.91.61.01.51.51.4-0.71.82.01.3
Stereotopy head waving duration, day 72.32.86.5-1.0-1.6-1.81.81.80.91.61.60.90.02.32.52.2
Locomotion velocity, session 83.23.86.0-1.7-2.2-2.32.12.41.21.92.01.4-0.72.32.32.0
Locomotion distance, session 80.40.62.40.30.20.0-0.60.2-0.50.10.1-0.91.31.10.91.5
Degree of sensitization distance2.22.23.51.51.51.7-1.6-1.6-1.8-1.6-1.6-1.91.4-0.9-1.2-0.4
Degree of sensitization stereotypy2.83.16.2-1.3-1.7-1.81.81.71.31.81.91.2-0.32.32.52.1
Conditioned locomotion0.80.91.31.21.11.1-1.1-1.0-1.1-1.0-1.0-1.01.0-0.6-0.6-0.4
Cocaine response after cond. corrected0.40.41.60.2-0.1-0.1-0.30.2-0.8-0.2-0.1-0.81.30.90.71.1
Cocaine response after cond. not corrected0.50.62.50.50.10.1-0.50.0-1.1-0.4-0.3-1.11.60.80.61.1
Cocaine response before conditioning0.00.00.10.20.10.0-0.10.0-0.2-0.1-0.0-0.40.40.10.10.3
Saline control response1.62.13.5-1.3-1.6-1.81.41.90.81.41.50.9-0.31.81.71.7
Bone: connectivity density1.01.52.5-1.5-1.4-1.21.61.31.41.31.21.3-1.40.60.30.3
Bone: cortical apparent density0.00.00.10.10.10.0-0.3-0.00.1-0.0-0.10.00.1-0.1-0.0-0.1
Bone: cortical area0.50.82.90.0-0.5-0.60.70.7-0.20.50.6-0.20.81.61.41.7
Bone: cortical porosity0.70.71.20.81.00.9-1.1-0.9-0.6-0.9-0.9-0.70.6-1.0-0.9-0.7
Bone: cortical porosity0.60.60.90.80.80.8-1.0-0.8-0.7-0.8-0.8-0.80.7-0.8-0.8-0.5
Bone: cortical thickness1.72.86.92.21.71.5-1.4-1.4-2.3-1.7-1.6-2.22.6-0.10.00.4
Bone: cortical thickness0.40.50.80.90.80.7-0.5-0.7-0.7-0.8-0.8-0.80.9-0.5-0.2-0.3
Bone: cortical tissue density0.00.00.1-0.00.1-0.0-0.3-0.00.2-0.0-0.00.1-0.1-0.2-0.1-0.2
Condit. Reinf. active minus inactive responses0.00.00.00.10.00.00.10.0-0.1-0.1-0.1-0.10.00.00.00.0
Condit. Reinf. active-inactive response ratio0.20.20.40.50.50.5-0.5-0.5-0.6-0.5-0.5-0.50.5-0.1-0.1-0.0
Condit. Reinf. active responses0.00.10.2-0.1-0.2-0.20.30.30.00.10.2-0.10.10.40.40.4
Condit. Reinf. inactive responses0.10.20.4-0.3-0.4-0.60.50.60.10.30.30.2-0.10.50.50.4
Incentive salience index mean0.10.10.20.30.40.4-0.4-0.4-0.4-0.3-0.3-0.40.4-0.1-0.1-0.0
Condit. Reinf. lever presses0.30.41.00.60.70.8-0.8-0.8-0.7-0.6-0.6-0.91.0-0.0-0.00.2
Condit. Reinf. active minus inactive responses1.01.23.6-0.9-0.9-1.00.51.10.51.01.10.10.71.71.61.9
Condit. Reinf. active-inactive response ratio0.10.10.3-0.3-0.1-0.1-0.10.10.40.30.3-0.10.20.30.20.5
Condit. Reinf. active responses1.72.34.8-1.5-1.6-1.71.21.80.61.41.50.60.22.22.02.1
Condit. Reinf. inactive responses1.41.83.5-1.4-1.6-1.61.41.70.21.21.20.7-0.11.91.71.6
Condit. Reinf. lever presses0.91.32.5-1.1-1.1-1.20.61.20.71.21.20.6-0.01.61.61.5
Condit. Reinf. lever reinforcers received1.82.65.4-1.5-1.7-1.71.31.80.61.51.60.60.22.32.12.2
Conditioned reinforcement - actives1.42.44.82.21.91.7-1.6-1.7-1.4-1.5-1.5-1.81.9-0.7-0.7-0.3
Conditioned reinforcement - inactives3.24.77.52.72.42.3-2.7-2.2-2.7-2.2-2.2-2.52.6-0.4-0.9-0.3
Conditioned locomotion0.20.30.60.40.60.6-0.8-0.6-0.8-0.5-0.5-0.60.80.20.4-0.0
Patch foraging indifference point 0 sec1.32.35.41.71.51.5-1.7-1.4-2.1-1.5-1.5-1.82.3-0.2-0.10.2
Patch foraging indifference point AUC1.21.83.9-1.2-1.4-1.41.31.30.41.21.20.50.21.91.82.0
Delay disc. indifference point, 0s delay0.10.10.4-0.3-0.2-0.10.00.10.60.20.2-0.10.10.1-0.00.4
Delay disc. indifference point, 16s delay0.10.20.6-0.10.10.20.0-0.20.3-0.2-0.20.1-0.6-0.7-0.7-0.7
Delay disc. indifference point, 2s delay0.10.10.50.10.0-0.10.30.10.70.20.10.2-0.4-0.4-0.1-0.2
Delay disc. indifference point, 24s delay0.50.61.21.00.80.8-0.7-0.7-0.8-0.8-0.8-1.10.9-0.5-0.5-0.1
Delay disc. indifference point, 4s delay0.10.10.3-0.3-0.3-0.30.40.40.50.20.2-0.1-0.1-0.0-0.10.3
Delay disc. indifference point, 8s delay0.50.51.30.40.70.9-1.0-0.8-0.6-0.7-0.7-1.01.1-0.4-0.3-0.0
Indifference point function ln k0.91.62.31.51.51.4-1.5-1.4-0.9-1.3-1.3-1.21.1-1.1-1.0-0.8
Indifference point function log k0.91.62.31.51.51.4-1.5-1.4-0.9-1.3-1.3-1.21.1-1.1-1.0-0.8
Patch foraging total patch changes 0 sec0.91.74.81.51.21.2-1.3-1.1-1.8-1.3-1.2-1.62.20.10.20.4
Patch foraging total patch changes 12 sec0.70.92.3-1.0-1.0-1.00.70.90.10.80.80.30.41.51.41.5
Patch foraging total patch changes 18 sec0.60.83.0-0.3-0.6-0.70.40.7-0.30.50.6-0.10.81.51.71.6
Patch foraging total patch changes 24 sec0.61.13.9-0.4-0.7-0.80.50.80.10.70.8-0.10.91.71.62.0
Patch foraging total patch changes 6 sec0.40.72.3-0.0-0.4-0.60.30.6-0.80.30.3-0.21.01.51.31.4
Patch foraging time to switch 0 sec0.20.31.2-0.10.0-0.10.10.10.40.10.00.5-1.1-0.8-0.9-1.0
Patch foraging water rate 0 sec0.71.43.0-1.2-1.2-1.10.91.11.01.21.21.0-0.31.61.71.3
Patch foraging water rate 12 sec1.22.44.81.81.71.7-1.9-1.5-1.8-1.5-1.5-1.92.2-0.4-0.40.1
Patch foraging water rate 18 sec0.20.31.0-0.5-0.4-0.40.30.41.00.60.60.8-0.50.00.4-0.0
Patch foraging water rate 24 sec0.50.72.21.10.80.7-0.9-0.5-0.6-0.5-0.5-1.21.50.30.50.9
Patch foraging water rate 6 sec0.20.21.00.30.20.1-0.4-0.0-0.3-0.1-0.1-0.61.00.50.70.7
Seeking ratio, delayed vs. immediate footshock1.01.24.20.20.60.7-0.2-0.80.4-0.6-0.70.4-1.0-2.0-1.8-2.0
Distance traveled before self-admin0.20.30.7-0.4-0.5-0.50.10.60.10.50.50.3-0.20.80.70.7
Distance traveled after self-admin0.30.31.4-0.7-0.2-0.10.30.10.60.20.20.5-1.2-0.7-0.8-0.7
Extensor digitorum longus weight4.216.722.8-4.8-4.5-4.34.64.14.74.54.44.6-4.22.62.61.8
Bone: elastic displacement0.40.51.10.70.70.7-0.3-0.8-0.5-0.7-0.7-0.30.1-1.0-1.1-1.0
Bone: elastic work0.00.00.1-0.00.00.10.4-0.1-0.1-0.1-0.10.1-0.1-0.1-0.0-0.2
Bone: endosteal estimation3.47.510.2-3.2-3.1-2.83.22.73.03.03.02.8-2.82.11.71.5
Bone: endosteal perimeter2.04.36.9-2.0-2.2-2.12.22.21.72.32.31.4-1.02.62.12.3
Epididymis fat weight0.62.15.5-0.7-1.2-1.41.41.60.81.31.40.30.32.21.92.3
Delta time in closed arm before/after self-admin0.60.62.1-0.40.00.20.2-0.30.7-0.0-0.10.4-1.2-1.2-1.5-1.1
Delta time in open arm before/after self-admin0.40.41.0-0.6-0.5-0.60.20.60.50.60.60.6-0.50.61.00.4
Diff in mean of infusions in LGA sessions1.72.15.8-1.1-1.3-1.31.11.40.61.41.40.6-0.12.42.22.1
Delay discount exponential model param0.10.10.2-0.1-0.2-0.30.20.2-0.10.30.20.4-0.30.50.30.1
Extinction: sum of active levers before priming0.70.72.60.1-0.2-0.3-0.30.4-0.20.30.4-0.41.11.61.61.5
Active lever presses in extinction session 60.20.21.20.40.20.1-0.5-0.1-1.1-0.4-0.4-0.30.80.50.20.1
Bone: final force0.50.81.7-0.8-0.9-0.81.00.90.30.80.90.4-0.21.31.21.2
Bone: final moment0.50.81.9-0.8-0.9-0.80.90.90.30.90.90.4-0.11.41.41.3
Food consumed during 24 hour testing period0.60.81.41.00.90.8-1.2-0.8-1.2-0.9-0.9-1.01.1-0.3-0.2-0.1
Glucose5.48.411.4-3.1-3.3-3.43.13.42.53.13.12.6-1.82.72.92.3
Heart weight0.10.20.80.30.20.10.1-0.10.90.20.10.4-0.7-0.6-0.5-0.4
Delay discount hyperbolic model param0.00.10.2-0.1-0.2-0.20.10.2-0.20.20.20.4-0.30.40.20.0
Intermittent access intake day 1-15 change0.40.81.51.01.01.0-0.9-1.0-1.2-1.0-1.0-0.90.8-0.6-0.7-0.4
Intermittent access intake escalation0.40.71.30.80.90.9-0.7-0.9-1.1-1.0-1.0-0.80.6-0.8-0.8-0.6
Intermittent access intake escalation 20.20.20.70.30.10.0-0.2-0.1-0.7-0.1-0.1-0.40.90.50.40.6
Intermitt. access day 1 inactive lever presses0.93.45.12.02.02.0-1.9-2.0-2.3-2.1-2.0-2.01.8-1.4-1.3-0.9
Intermitt. access day 15 inactive lever presses0.51.12.91.30.70.6-0.9-0.4-1.6-0.6-0.6-1.21.71.00.71.0
Intermitt. access escalation Index0.30.40.80.60.70.7-0.9-0.8-0.5-0.7-0.7-0.60.6-0.6-0.6-0.4
Intermittent access day 1 total infusions1.32.15.02.21.81.6-1.5-1.5-1.4-1.3-1.3-1.71.9-0.1-0.1-0.0
Intermittent access day 15 total infusions2.53.76.12.32.22.1-2.0-2.0-2.5-2.1-2.0-2.22.2-0.7-0.8-0.5
Intermittent access terminal intake (last 3 days)2.63.46.42.22.02.0-1.9-1.9-2.3-1.9-1.9-2.22.5-0.4-0.4-0.2
Intermittent access total infusions2.73.26.22.52.12.0-1.7-1.9-2.1-1.9-1.8-2.12.2-0.5-0.6-0.4
Intermittent access day 1 locomotion3.03.85.32.32.22.3-2.2-2.1-2.1-2.1-2.0-2.32.1-0.9-0.8-0.7
Intermittent access day 15 total locomotion0.91.75.31.11.01.0-1.3-0.9-1.8-1.0-0.9-1.72.31.01.10.9
Intermittent access total locomotion3.84.610.02.42.22.2-2.3-2.1-2.8-2.1-2.1-2.83.20.10.00.2
Intermittent access standard deviation0.10.21.00.30.10.10.10.0-1.0-0.4-0.3-0.50.70.50.30.4
Left kidney weight2.411.218.94.34.03.9-3.7-3.7-2.7-3.4-3.4-3.52.8-2.7-2.7-1.6
Right kidney weight2.210.215.74.03.63.6-3.4-3.4-3.1-3.4-3.4-3.53.2-2.3-2.3-1.4
Cocaine induced anxiety0.10.20.50.40.20.1-0.3-0.2-0.6-0.3-0.3-0.60.70.40.60.5
Post-drug Anxiety0.90.93.1-0.4-0.7-0.70.30.8-0.10.50.6-0.40.81.61.81.7
Baseline Anxiety0.00.00.1-0.10.00.1-0.2-0.10.30.10.10.0-0.0-0.3-0.3-0.1
Tail length1.14.36.52.22.12.1-2.3-2.1-2.6-2.4-2.3-2.42.4-1.2-1.1-0.8
Length with tail0.41.63.51.31.31.3-1.4-1.3-1.5-1.4-1.3-1.71.9-0.5-0.10.0
Length without tail0.10.31.6-0.2-0.2-0.10.30.10.10.30.4-0.10.40.91.31.0
Times rat made contact with spout8.49.713.23.33.33.4-3.5-3.4-3.6-3.4-3.4-3.32.9-2.2-2.3-1.6
Lifetime Intake1.82.24.32.11.81.7-1.3-1.6-1.4-1.6-1.6-1.51.3-0.9-1.0-0.9
Liver weight, left5.28.612.13.53.43.3-2.9-3.4-2.5-3.2-3.2-2.62.2-3.0-2.5-2.2
Liver weight, right3.15.49.22.12.42.5-2.1-2.5-1.9-2.5-2.5-1.60.6-3.0-2.8-2.6
Locomotor activity2.64.16.61.91.92.0-2.1-1.9-2.5-2.3-2.2-2.62.5-1.4-1.3-0.6
Locomotor testing distance1.22.24.01.51.51.4-1.4-1.4-2.0-1.7-1.7-1.81.8-1.0-1.0-0.5
Locomotor testing rearing0.51.01.70.81.11.2-1.3-1.3-1.0-1.0-1.0-1.21.2-0.7-0.6-0.3
Locomotion in novel chamber0.10.10.50.10.30.3-0.7-0.4-0.3-0.2-0.2-0.40.50.20.00.4
Locomotion in novel chamber post-restriction0.40.62.1-0.8-0.5-0.50.70.41.10.70.61.2-1.5-0.4-0.2-0.6
Fecal boli incidents, locomotor time 10.20.30.80.90.50.5-0.8-0.40.1-0.1-0.1-0.70.60.20.30.6
Change in fecal boli incidents, locomotor task2.12.13.00.71.21.5-1.3-1.6-1.6-1.7-1.7-1.41.1-1.6-1.7-1.3
Time >=10cm from walls, locomotor time 10.30.30.70.20.40.6-0.7-0.7-0.8-0.6-0.6-0.70.8-0.2-0.20.0
Bouts of movement, locomotor time 10.10.10.4-0.6-0.4-0.30.20.30.30.40.40.3-0.10.50.50.3
Total resting periods, locomotor time 10.10.10.4-0.6-0.3-0.30.10.30.10.30.30.10.00.60.60.5
Rest time, locomotor task time 10.70.82.0-1.0-1.0-0.90.70.90.80.80.9-0.0-0.11.21.21.4
Distance moved, locomotor task time 10.71.03.70.50.70.7-0.2-0.8-0.4-0.7-0.80.4-0.8-1.7-1.6-1.9
Vertical activity count, locomotor time 10.00.10.40.40.10.10.1-0.1-0.0-0.0-0.10.5-0.6-0.3-0.3-0.6
Time >=10cm from walls, locomotor time 20.50.71.9-1.4-1.0-0.81.10.61.00.70.71.1-1.1-0.2-0.2-0.4
Bouts of movement, locomotor time 21.52.45.2-1.2-1.5-1.51.11.61.21.61.60.60.42.22.12.3
Total resting periods, locomotor time 20.71.23.9-0.7-0.9-0.90.50.90.50.91.0-0.01.01.71.62.0
Rest time, locomotor task time 20.50.72.30.30.00.1-0.4-0.1-0.8-0.3-0.3-1.21.51.00.91.3
Distance moved, locomotor task time 21.11.34.1-0.7-0.1-0.20.70.11.00.40.31.6-2.0-1.4-1.4-1.9
Vertical activity count, locomotor time 20.70.92.9-0.9-0.6-0.71.00.51.40.90.81.5-1.7-0.3-0.4-0.7
Light reinforcement 10.10.10.5-0.5-0.3-0.50.30.40.70.40.40.3-0.20.10.10.3
Light reinforcement 23.96.07.5-2.7-2.7-2.62.32.52.52.72.72.1-1.62.42.62.1
Bone: marrow area3.78.010.9-3.3-3.2-2.93.22.83.13.13.12.8-2.82.31.81.6
Bone: maximum diameter1.42.75.7-1.3-1.6-1.71.61.81.01.71.70.8-0.22.42.02.2
Bone: maximum force0.40.81.4-1.0-0.9-0.81.20.90.50.90.90.8-0.61.00.80.7
Bone: maximum moment0.40.71.1-0.9-0.9-0.81.10.80.50.90.90.7-0.51.10.90.9
Mean time between licks in bursts1.12.83.71.71.71.7-1.2-1.6-1.9-1.9-1.9-1.61.0-1.7-1.9-1.5
Mean num. licks in bursts0.61.02.61.00.70.8-1.0-0.7-1.6-0.9-0.9-1.31.60.30.50.6
Cd content in liver1.21.44.2-1.2-1.1-1.01.40.91.41.00.91.6-2.0-0.3-0.3-0.7
Co content in liver0.10.10.5-0.2-0.2-0.30.10.30.70.40.40.10.00.10.30.4
Cu content in liver0.30.30.60.80.80.6-0.7-0.6-0.6-0.6-0.6-0.50.6-0.1-0.1-0.2
Fe content in liver0.10.11.00.20.10.0-0.3-0.1-0.20.10.00.10.50.51.00.4
K content in liver0.20.20.5-0.5-0.4-0.50.30.40.70.50.50.7-0.60.10.1-0.2
Mg content in liver0.40.41.1-0.6-0.6-0.80.40.81.10.70.70.9-0.70.20.4-0.0
Mn content in liver0.50.51.0-0.6-0.7-1.00.61.00.60.70.70.3-0.10.90.80.9
Na content in liver4.04.36.7-2.0-2.1-2.21.82.21.72.32.31.7-0.82.42.62.0
Rb content in liver0.50.61.01.01.00.9-0.8-1.0-0.2-0.8-0.8-0.50.3-0.8-0.7-0.7
Se content in liver0.40.40.80.60.70.6-0.4-0.7-0.8-0.9-0.9-0.40.1-0.8-0.4-0.9
Sr content in liver1.41.22.01.21.31.3-1.4-1.3-0.8-1.1-1.1-1.00.9-0.9-1.0-0.7
Zn content in liver0.00.00.1-0.10.0-0.1-0.0-0.00.0-0.1-0.10.0-0.2-0.1-0.3-0.3
Bone: minimum diameter4.68.411.8-3.0-3.2-3.23.43.32.63.13.12.7-2.22.82.52.2
Time in familiar zone, hab. session 10.20.20.70.1-0.0-0.1-0.10.1-0.20.10.1-0.50.60.60.50.8
Time in novel zone, hab. session 11.01.03.7-0.9-0.7-0.71.00.61.00.60.51.5-1.9-0.8-0.7-1.4
Total zone transitions, hab. session 11.21.63.81.41.11.1-1.3-0.9-1.8-1.4-1.3-1.91.7-0.2-0.50.3
Total locomotion distance, hab. session 11.11.62.91.41.21.2-1.1-1.0-1.7-1.5-1.5-1.71.3-0.9-1.0-0.5
Locomotion velocity, hab. session 11.31.83.11.41.31.3-1.3-1.1-1.8-1.6-1.5-1.71.3-1.0-1.1-0.5
Time in familiar zone, hab. session 20.70.71.3-0.7-0.8-1.00.61.10.80.91.00.3-0.11.00.91.1
Time in novel zone, hab. session 20.50.61.70.40.60.7-0.5-0.8-0.4-0.7-0.70.0-0.3-1.1-1.0-1.3
Total zone transitions, hab. session 20.70.92.60.80.80.8-1.1-0.6-1.2-0.8-0.7-1.61.50.3-0.30.7
Total locomotion distance, hab. session 21.82.34.01.61.61.6-1.8-1.4-1.7-1.6-1.6-2.01.5-1.0-1.3-0.4
Locomotion velocity, hab. session 21.72.34.01.51.61.6-1.7-1.4-1.7-1.6-1.6-2.01.5-1.0-1.3-0.4
Novel to familiar place preference ratio0.40.52.0-0.20.20.40.3-0.50.0-0.3-0.30.5-1.0-1.0-1.1-1.4
Novelty place preference0.50.62.1-0.6-0.10.10.6-0.20.50.10.00.9-1.4-1.0-1.0-1.4
Time in novel zone, NPP test0.50.62.2-0.7-0.3-0.10.70.00.70.30.21.0-1.5-0.8-0.8-1.3
Total zone transitions, NPP test0.30.41.40.20.1-0.0-0.70.2-0.6-0.10.0-0.81.20.90.71.2
Total locomotion distance, NPP test0.20.30.60.40.60.6-0.7-0.5-0.6-0.6-0.6-0.60.3-0.5-0.6-0.4
Locomotion velocity, NPP test0.40.61.00.60.80.9-1.0-0.8-0.9-0.8-0.8-0.80.5-0.7-0.8-0.5
Intraocular pressure0.30.51.3-0.4-0.2-0.30.50.30.70.20.10.9-1.1-0.9-0.9-1.1
Delta distance traveled before/after self-admin0.30.31.2-0.00.30.40.2-0.50.6-0.2-0.3-0.1-0.6-1.1-1.0-0.9
Delta ambulatory time before/after self-admin0.20.31.20.20.30.40.2-0.40.4-0.3-0.3-0.2-0.4-1.1-1.0-0.7
Parametrial fat weight3.07.011.7-3.3-3.0-2.83.02.83.32.62.63.1-3.40.60.40.1
Pavlov. Cond. lever latency0.00.00.2-0.0-0.0-0.10.40.10.10.00.00.2-0.3-0.3-0.3-0.4
Pavlov. Cond. magazine entry latency0.50.71.20.70.91.0-1.1-1.0-0.6-0.9-0.9-0.60.4-0.9-0.8-0.8
Pavlov. Cond. change in total contacts0.10.10.20.40.30.2-0.3-0.30.0-0.2-0.2-0.30.5-0.00.20.2
Pavlov. Cond. index score0.10.10.30.20.30.4-0.6-0.5-0.3-0.4-0.4-0.30.2-0.3-0.3-0.2
Pavlov. Cond. latency score0.20.20.50.30.40.6-0.7-0.6-0.3-0.5-0.5-0.40.3-0.4-0.4-0.3
Pavlov. Cond. lever contacts0.10.10.3-0.1-0.1-0.0-0.2-0.0-0.20.00.0-0.20.40.50.40.5
Pavlov. Cond. magazine entry number0.20.30.7-0.2-0.5-0.60.70.70.10.50.50.10.20.70.70.9
Pavlov. Cond. intertrial magazine entries3.94.76.3-2.2-2.4-2.52.42.41.92.32.32.3-1.62.02.21.5
Pavlov. Cond. lever-magazine prob. diff.0.00.10.20.10.20.3-0.4-0.3-0.1-0.2-0.2-0.20.0-0.2-0.2-0.2
Pavlov. Cond. response bias0.10.10.40.30.40.4-0.6-0.4-0.3-0.4-0.4-0.30.3-0.2-0.2-0.2
Pavlov. Cond. lever latency1.21.73.71.01.21.3-0.8-1.3-0.9-1.4-1.4-0.6-0.1-1.9-1.8-1.9
Pavlov. Cond. magazine entry latency0.20.31.20.20.1-0.0-0.50.1-0.5-0.1-0.0-0.61.10.60.50.9
Pavlov. Cond. change in total contacts0.71.22.4-0.9-1.1-1.10.91.10.91.21.20.5-0.01.41.41.5
Pavlov. Cond. index score0.50.62.3-0.3-0.4-0.60.10.6-0.00.50.6-0.20.91.31.31.5
Pavlov. Cond. latency score0.30.41.70.0-0.1-0.2-0.30.2-0.20.20.3-0.51.11.01.01.3
Pavlov. Cond. lever contacts1.41.93.6-1.2-1.3-1.40.91.41.11.51.50.8-0.11.91.81.9
Pavlov. Cond. magazine entry number0.10.10.50.10.20.30.1-0.3-0.2-0.3-0.30.1-0.5-0.5-0.4-0.7
Pavlov. Cond. intertrial magazine entries0.40.61.3-0.8-0.9-1.01.11.00.40.70.70.6-0.50.70.90.5
Pavlov. Cond. lever-magazine prob. diff.0.40.62.3-0.1-0.3-0.5-0.00.5-0.10.40.5-0.31.01.31.21.5
Pavlov. Cond. response bias1.21.73.4-1.0-1.3-1.30.91.30.91.31.40.60.11.81.81.8
Time in closed arm before self-admin0.40.51.0-0.5-0.7-0.90.51.00.80.80.80.5-0.40.60.70.7
Time in closed arm after self-admin1.31.45.0-0.7-0.3-0.30.80.31.80.50.51.0-2.2-1.5-1.7-1.2
Time in open arm before self-admin0.10.10.20.10.20.3-0.1-0.4-0.3-0.2-0.2-0.20.3-0.3-0.4-0.2
Time in open arm after self-admin0.91.04.1-0.6-0.8-0.80.30.8-0.00.80.80.30.61.82.01.4
Bone: periosteal estimation1.83.85.7-1.9-2.1-2.02.42.01.62.12.11.6-1.22.21.91.8
Bone: periosteal perimeter1.01.84.8-0.9-1.2-1.21.31.30.51.31.30.40.12.21.82.0
Bone: post-yield work0.71.01.5-1.0-1.1-1.01.01.00.71.11.10.9-0.51.21.11.0
Progressive ratio test 1 active lever presses3.03.76.82.62.52.3-2.1-2.3-1.6-2.0-2.0-2.01.7-1.1-1.1-0.9
Progressive ratio test 1 breakpoint2.83.56.32.52.42.3-2.1-2.2-1.5-1.9-1.9-1.91.7-1.0-1.0-0.9
Progressive ratio test 1 inactive lever presses2.53.66.02.52.12.1-1.7-2.0-2.1-2.1-2.1-1.81.7-1.4-1.4-1.3
Progressive ratio test 2 active lever presses3.43.96.02.52.22.1-2.0-2.1-2.4-2.2-2.2-2.22.2-0.8-1.0-0.8
Progressive ratio test 2 breakpoint3.13.65.52.32.12.0-1.9-2.0-2.3-2.1-2.1-2.12.1-0.8-1.0-0.8
Progressive ratio test 2 inactive lever presses2.54.110.02.61.91.8-2.2-1.7-2.8-1.9-1.8-2.63.20.60.20.7
Incentive Sensitization - Responses0.81.12.31.51.00.9-1.1-0.8-1.5-1.0-1.0-1.21.50.2-0.2-0.0
Incentive Sensitization - Breakpoint0.91.22.81.51.00.9-1.2-0.8-1.6-1.1-1.0-1.21.70.2-0.10.1
Sum of active levers in priming session hrs 5-60.10.10.50.10.10.0-0.4-0.0-0.5-0.1-0.1-0.10.40.50.70.2
Progressive ratio0.30.41.0-1.0-0.8-0.70.90.70.40.50.50.7-0.50.30.30.1
Food seeking constrained by brief footshock1.31.62.71.41.31.2-0.9-1.2-1.3-1.4-1.5-1.00.3-1.4-1.7-1.3
Seeking ratio, punishment vs. effort0.91.32.01.41.31.2-1.2-1.1-1.0-1.2-1.2-0.90.2-1.1-1.3-1.1
Retroperitoneal fat weight1.87.612.2-3.1-3.0-3.13.13.13.53.02.92.9-2.91.51.31.2
Reaction time number correct0.10.30.80.1-0.2-0.30.40.3-0.10.20.2-0.20.70.90.80.9
Reaction time mean minus median0.20.41.30.40.40.5-0.7-0.6-1.2-0.7-0.7-0.81.0-0.20.00.1
Reaction time mean minus median AUC0.10.31.0-0.2-0.1-0.0-0.3-0.0-0.8-0.1-0.0-0.51.00.81.00.9
Reaction time num false alarms2.33.24.21.91.81.9-1.4-1.9-2.0-2.0-2.0-1.51.0-1.9-1.7-1.8
Reaction time num false alarms AUC2.33.64.72.01.92.0-1.5-2.0-2.1-2.2-2.2-1.71.1-2.0-1.8-1.9
Reaction time trials correct on left0.10.30.80.1-0.2-0.30.40.3-0.10.20.2-0.20.70.90.80.9
Reaction time trials on left0.10.30.90.1-0.2-0.30.40.4-0.10.20.3-0.20.70.90.90.9
Reaction time mean0.30.41.6-0.6-0.4-0.10.50.00.30.10.00.8-1.3-0.9-0.7-1.1
Reaction time mean AUC0.10.20.6-0.5-0.3-0.10.30.0-0.0-0.0-0.10.5-0.8-0.6-0.4-0.8
Median of all reaction times0.70.93.7-0.9-0.6-0.40.90.30.90.40.31.3-1.9-1.0-0.8-1.4
Reaction time omissions0.00.00.2-0.5-0.20.00.1-0.0-0.2-0.0-0.00.0-0.3-0.2-0.2-0.3
Reaction time false alarm rate2.63.65.41.81.92.0-1.6-2.1-1.8-2.1-2.1-1.40.7-2.3-2.0-2.2
Reaction time premature initiation rate1.21.72.9-1.3-1.4-1.61.41.51.71.41.41.1-1.00.91.11.0
Reaction time premature initiations0.91.72.5-1.0-1.4-1.61.41.51.31.21.30.8-0.31.41.61.5
Std. dev. reaction times0.30.51.30.30.50.7-0.6-0.8-1.1-0.8-0.9-0.60.4-0.8-0.7-0.6
Reaction time trials completed0.10.30.90.1-0.2-0.30.40.4-0.10.20.3-0.20.70.90.90.9
Reaction time trials AUC0.20.41.2-0.2-0.5-0.50.60.60.20.50.50.10.41.11.01.0
Run reversals in cocaine runway, females0.50.50.90.80.90.8-0.9-0.8-0.7-0.7-0.7-0.80.9-0.20.1-0.0
Run reversals in cocaine runway, males0.50.52.10.4-0.2-0.30.10.4-0.30.20.3-0.51.11.11.11.5
Latency to leave start box in cocaine runway0.00.00.2-0.2-0.1-0.00.2-0.00.3-0.0-0.00.0-0.3-0.4-0.3-0.2
Latency to leave start box in cocaine runway, F0.40.52.1-0.10.20.20.3-0.30.1-0.4-0.50.0-0.7-1.3-1.4-1.1
Latency to leave start box in cocaine runway, M0.40.41.7-0.0-0.3-0.30.00.40.30.50.5-0.10.51.01.31.2
Std. dev. time between licks in bursts0.40.51.40.90.70.4-0.7-0.4-1.1-0.7-0.6-0.91.20.30.40.4
Total sessions with >9 infusions0.70.92.01.01.01.0-0.6-1.0-0.3-0.9-0.9-0.2-0.3-1.2-1.4-1.4
Short access day 1 total inactive lever presses1.11.52.51.01.21.3-1.0-1.3-1.6-1.4-1.4-0.90.6-1.1-1.3-1.3
Short access day 10 total inactive lever presses0.10.20.7-0.8-0.6-0.50.30.40.10.20.20.7-0.6-0.2-0.1-0.5
Short access day 1 total infusions1.11.54.51.11.11.0-0.5-1.1-0.1-1.0-1.10.0-0.7-1.9-2.0-2.1
Short access day 10 total infusions0.70.92.90.80.90.8-0.2-0.90.0-0.7-0.80.0-0.6-1.4-1.5-1.7
Short access total infusions0.81.02.81.11.00.9-0.4-0.9-0.1-0.9-0.9-0.2-0.4-1.4-1.5-1.7
Short access day 1 locomotion1.92.45.30.81.51.7-1.2-1.7-1.0-1.6-1.6-0.7-0.1-2.1-2.0-2.3
Short access day 10 total locomotion0.00.10.3-0.20.10.3-0.5-0.10.10.00.1-0.20.30.30.30.3
Short access total locomotion0.20.20.50.20.50.7-0.6-0.7-0.4-0.5-0.5-0.40.3-0.3-0.3-0.5
One hour access (0.3 mA shock)2.02.35.22.11.71.5-1.5-1.4-2.0-1.3-1.3-1.82.30.40.10.4
Compulsive drug intake0.81.01.5-1.2-1.1-1.11.11.01.11.11.10.9-0.90.70.50.7
One hour access (shock baseline)2.13.25.92.42.01.8-1.9-1.8-2.4-1.8-1.7-2.02.3-0.1-0.3-0.2
Social response proportion0.80.91.40.80.91.0-1.1-1.2-0.7-1.1-1.1-1.01.2-1.10.0-0.6
Social responses0.81.01.80.81.01.1-1.0-1.3-0.8-1.1-1.1-1.21.3-1.0-0.3-0.3
Social time0.10.20.6-0.2-0.3-0.4-0.00.30.10.30.3-0.10.40.50.80.7
Soleus weight1.03.04.0-1.8-1.9-1.91.41.91.72.02.01.3-0.82.01.91.9
Bone: stiffness0.00.00.2-0.2-0.1-0.00.20.0-0.10.10.1-0.00.10.40.30.4
Tibialis anterior weight7.625.736.5-6.0-5.6-5.35.55.15.85.55.55.9-5.63.13.01.9
Time to tail flick, vehicle, before self-admin1.81.93.71.11.31.4-1.6-1.4-1.1-1.4-1.4-0.60.3-1.6-1.9-1.7
Time to tail flick, vehicle, after self-admin1.11.52.3-1.4-1.3-1.31.31.21.51.31.31.2-0.90.81.10.7
Time to tail flick, test, before self-admin1.92.05.00.91.21.4-1.4-1.5-0.8-1.4-1.4-1.00.3-1.9-2.2-1.6
Time to tail flick, test, after self-admin0.70.71.90.70.91.0-1.4-1.0-0.3-0.7-0.7-0.90.4-0.8-1.0-0.3
Delta time to tail flick, vehicle, before/after SA2.52.44.6-1.4-1.5-1.61.61.61.51.61.60.9-0.51.62.11.7
Delta time to tail flick, test, before/after SA0.10.10.4-0.0-0.1-0.1-0.10.20.10.20.3-0.10.20.50.60.7
Tibia length0.00.10.20.10.30.40.2-0.5-0.1-0.2-0.2-0.10.2-0.0-0.1-0.1
Ambulatory time before self-admin0.60.81.5-0.9-1.0-1.00.61.10.40.90.90.8-0.71.21.00.9
Ambulatory time after self-admin0.50.62.0-1.0-0.7-0.60.70.70.90.60.60.9-1.4-0.1-0.3-0.3
Bone: tissue strength0.40.40.90.60.70.7-0.9-0.7-0.5-0.7-0.7-0.70.5-0.7-0.5-0.4
Total heroin consumption1.11.24.20.90.90.9-1.2-0.8-1.3-0.8-0.8-1.62.00.70.51.1
Bone: trabecular number0.10.20.5-0.6-0.5-0.40.70.50.70.30.30.5-0.7-0.3-0.3-0.3
Bone: trabecular spacing2.83.75.82.42.32.1-2.2-2.2-1.9-2.0-2.0-2.12.0-1.3-1.0-0.7
Bone: trabecular thickness1.11.32.6-1.3-1.3-1.21.61.21.21.11.11.3-1.20.60.60.3
Bone: trabecular tissue density1.11.72.41.61.51.4-1.5-1.4-1.2-1.4-1.4-1.51.1-0.9-1.2-0.6
Water consumed over 24 hours0.60.81.50.90.90.9-1.2-0.9-1.2-1.0-0.9-1.21.2-0.3-0.2-0.0
Number of responses in last shaping day2.32.53.71.51.81.8-1.3-1.8-1.2-1.7-1.7-1.40.7-1.9-1.8-1.5