Hub : Genes

Tamalin

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Tamalin 0.03 0.03 4.2e-03 0.01 0.01 0.01 0.01 1.5e-02 2.1e-02 1.9e-02 3.7e-02
2 OFC intron excision ratio chr7_134223631_134223740 0.13 0.11 9.9e-03 0.1 0.09 0.08 0.09 3.0e-03 4.4e-03 5.0e-03 3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.10.2-0.40.2
Area under the delay curve0.00.10.1-0.10.4
BMI with tail0.93.13.5-1.91.7
BMI without tail0.31.31.6-1.21.1
Body weight0.31.31.5-1.21.1
Weight adjusted by age1.03.03.1-1.71.8
Bone surface0.00.10.1-0.40.2
Bone volume0.20.40.6-0.80.5
Breakpoint value in progressive ratio session0.00.10.10.1-0.3
Number of licking bursts0.00.00.0-0.20.2
Context. condit. distance diff. score0.10.10.20.3-0.4
Locomotion velocity, session 11.01.11.11.0-1.0
Locomotion distance, session 10.10.20.20.4-0.4
Locomotion velocity, session 20.60.70.80.9-0.8
Locomotion distance, session 20.50.70.70.8-0.9
Locomotion velocity, session 32.52.83.01.7-1.6
Locomotion distance, session 33.03.43.51.9-1.8
Stereotopy head waving bouts, day 31.72.02.2-1.51.4
Stereotopy head waving duration, day 30.10.10.1-0.40.3
Locomotion velocity, session 71.82.02.21.4-1.5
Locomotion distance, session 73.64.64.62.1-2.1
Stereotopy head waving bouts, day 74.85.65.8-2.32.4
Stereotopy head waving duration, day 72.83.53.6-1.81.9
Locomotion velocity, session 80.00.00.00.1-0.1
Locomotion distance, session 81.21.71.71.3-1.3
Degree of sensitization distance0.10.10.2-0.40.3
Degree of sensitization stereotypy3.53.94.2-1.92.0
Conditioned locomotion0.40.50.80.4-0.9
Cocaine response after cond. corrected0.10.20.3-0.30.5
Cocaine response after cond. not corrected0.00.00.10.20.1
Cocaine response before conditioning1.61.92.01.4-1.4
Saline control response0.20.30.30.6-0.6
Bone: connectivity density0.10.20.20.4-0.4
Bone: cortical apparent density1.42.32.6-1.61.4
Bone: cortical area0.20.40.4-0.70.6
Bone: cortical porosity1.01.11.21.0-1.1
Bone: cortical porosity1.21.41.61.1-1.2
Bone: cortical thickness0.10.20.2-0.50.4
Bone: cortical thickness0.40.50.50.7-0.7
Bone: cortical tissue density1.32.12.4-1.51.3
Condit. Reinf. active minus inactive responses0.00.00.00.00.1
Condit. Reinf. active-inactive response ratio0.20.20.20.5-0.4
Condit. Reinf. active responses0.00.00.00.1-0.1
Condit. Reinf. inactive responses0.00.00.0-0.1-0.0
Incentive salience index mean0.10.20.2-0.30.5
Condit. Reinf. lever presses0.60.91.0-0.91.0
Condit. Reinf. active minus inactive responses0.71.01.3-1.10.9
Condit. Reinf. active-inactive response ratio0.40.60.9-0.90.6
Condit. Reinf. active responses0.71.01.4-1.20.7
Condit. Reinf. inactive responses0.10.10.2-0.50.2
Condit. Reinf. lever presses0.81.21.21.1-1.1
Condit. Reinf. lever reinforcers received0.20.30.5-0.70.2
Conditioned reinforcement - actives0.10.50.80.5-0.9
Conditioned reinforcement - inactives0.51.31.41.1-1.2
Conditioned locomotion0.71.01.10.9-1.1
Patch foraging indifference point 0 sec0.20.60.70.8-0.8
Patch foraging indifference point AUC0.10.20.40.60.3
Delay disc. indifference point, 0s delay0.00.00.10.20.2
Delay disc. indifference point, 16s delay0.00.00.0-0.10.1
Delay disc. indifference point, 2s delay5.25.86.5-2.22.5
Delay disc. indifference point, 24s delay0.00.00.0-0.10.1
Delay disc. indifference point, 4s delay0.00.10.1-0.10.3
Delay disc. indifference point, 8s delay0.20.30.40.7-0.3
Indifference point function ln k0.31.01.8-1.40.5
Indifference point function log k0.31.01.8-1.40.5
Patch foraging total patch changes 0 sec0.41.11.21.0-1.1
Patch foraging total patch changes 12 sec0.81.11.61.3-0.8
Patch foraging total patch changes 18 sec0.61.52.21.5-0.8
Patch foraging total patch changes 24 sec0.31.21.81.3-0.7
Patch foraging total patch changes 6 sec0.40.70.80.9-0.7
Patch foraging time to switch 0 sec0.10.60.8-0.90.6
Patch foraging water rate 0 sec0.20.71.21.1-0.5
Patch foraging water rate 12 sec0.20.81.21.1-0.6
Patch foraging water rate 18 sec0.00.10.10.3-0.3
Patch foraging water rate 24 sec0.00.00.10.3-0.0
Patch foraging water rate 6 sec0.30.50.90.9-0.3
Seeking ratio, delayed vs. immediate footshock0.00.00.00.0-0.0
Distance traveled before self-admin0.10.30.30.6-0.6
Distance traveled after self-admin2.34.04.51.9-2.1
Extensor digitorum longus weight6.726.928.1-5.35.1
Bone: elastic displacement3.44.34.42.1-2.1
Bone: elastic work2.63.43.51.8-1.9
Bone: endosteal estimation0.00.10.1-0.30.2
Bone: endosteal perimeter0.30.80.8-0.90.8
Epididymis fat weight1.78.68.72.9-2.9
Delta time in closed arm before/after self-admin0.10.10.20.2-0.4
Delta time in open arm before/after self-admin2.42.82.91.6-1.7
Diff in mean of infusions in LGA sessions0.50.91.0-1.00.8
Delay discount exponential model param0.10.10.20.2-0.5
Extinction: sum of active levers before priming0.71.11.1-1.11.0
Active lever presses in extinction session 60.70.70.80.9-0.8
Bone: final force0.00.00.00.0-0.0
Bone: final moment0.00.00.00.1-0.2
Food consumed during 24 hour testing period0.40.81.20.6-1.1
Glucose0.10.10.10.4-0.4
Heart weight0.30.60.60.8-0.7
Delay discount hyperbolic model param0.20.20.40.3-0.6
Intermittent access intake day 1-15 change0.31.42.00.9-1.4
Intermittent access intake escalation0.10.50.80.4-0.9
Intermittent access intake escalation 20.30.50.70.6-0.8
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.2
Intermitt. access day 15 inactive lever presses0.00.00.00.2-0.2
Intermitt. access escalation Index0.51.72.0-1.11.4
Intermittent access day 1 total infusions0.10.30.40.6-0.5
Intermittent access day 15 total infusions0.10.30.40.4-0.6
Intermittent access terminal intake (last 3 days)0.10.10.20.2-0.5
Intermittent access total infusions0.10.10.20.3-0.4
Intermittent access day 1 locomotion0.50.91.01.0-1.0
Intermittent access day 15 total locomotion1.24.65.02.0-2.2
Intermittent access total locomotion1.62.02.51.2-1.6
Intermittent access standard deviation0.63.03.01.7-1.7
Left kidney weight0.00.20.2-0.40.5
Right kidney weight0.21.61.7-1.21.3
Cocaine induced anxiety0.00.00.1-0.2-0.1
Post-drug Anxiety0.20.20.40.1-0.6
Baseline Anxiety0.00.10.1-0.30.1
Tail length0.00.10.10.3-0.3
Length with tail0.00.00.0-0.20.1
Length without tail0.00.00.0-0.20.2
Times rat made contact with spout0.50.50.60.8-0.7
Lifetime Intake0.60.80.80.9-0.9
Liver weight, left0.00.00.0-0.10.1
Liver weight, right0.10.10.10.3-0.4
Locomotor activity0.10.10.10.2-0.3
Locomotor testing distance0.20.60.80.9-0.6
Locomotor testing rearing0.41.42.01.4-0.9
Locomotion in novel chamber1.11.41.5-1.21.2
Locomotion in novel chamber post-restriction0.30.81.00.8-1.0
Fecal boli incidents, locomotor time 11.23.33.41.8-1.8
Change in fecal boli incidents, locomotor task1.11.11.2-1.11.1
Time >=10cm from walls, locomotor time 10.10.10.20.1-0.4
Bouts of movement, locomotor time 10.00.00.00.0-0.0
Total resting periods, locomotor time 10.10.10.10.3-0.2
Rest time, locomotor task time 10.20.30.40.7-0.3
Distance moved, locomotor task time 10.10.30.4-0.60.4
Vertical activity count, locomotor time 10.21.51.9-1.41.0
Time >=10cm from walls, locomotor time 20.10.20.30.4-0.5
Bouts of movement, locomotor time 20.51.71.7-1.31.3
Total resting periods, locomotor time 20.62.52.7-1.51.6
Rest time, locomotor task time 20.00.00.00.10.2
Distance moved, locomotor task time 20.00.10.1-0.30.1
Vertical activity count, locomotor time 20.10.30.4-0.70.3
Light reinforcement 10.10.40.70.8-0.3
Light reinforcement 20.00.10.10.30.2
Bone: marrow area0.00.00.0-0.20.1
Bone: maximum diameter0.20.40.4-0.70.6
Bone: maximum force0.20.40.5-0.70.6
Bone: maximum moment0.10.20.3-0.50.4
Mean time between licks in bursts0.10.40.70.5-0.8
Mean num. licks in bursts0.41.01.11.0-0.9
Cd content in liver0.40.40.50.7-0.5
Co content in liver0.10.10.2-0.30.5
Cu content in liver0.00.00.0-0.10.1
Fe content in liver0.00.00.00.2-0.1
K content in liver0.10.10.10.30.3
Mg content in liver0.40.40.60.8-0.5
Mn content in liver0.20.20.4-0.60.3
Na content in liver0.00.00.1-0.10.3
Rb content in liver0.20.20.4-0.2-0.6
Se content in liver0.81.01.21.1-0.9
Sr content in liver0.10.10.1-0.2-0.3
Zn content in liver1.11.21.41.2-1.1
Bone: minimum diameter0.40.70.8-0.90.8
Time in familiar zone, hab. session 10.00.00.00.1-0.2
Time in novel zone, hab. session 10.50.50.6-0.60.8
Total zone transitions, hab. session 11.21.61.7-1.31.3
Total locomotion distance, hab. session 10.00.00.00.1-0.1
Locomotion velocity, hab. session 10.00.00.00.1-0.1
Time in familiar zone, hab. session 20.20.30.40.4-0.6
Time in novel zone, hab. session 20.40.40.5-0.60.7
Total zone transitions, hab. session 20.10.10.10.3-0.3
Total locomotion distance, hab. session 20.20.30.30.5-0.6
Locomotion velocity, hab. session 20.30.50.50.7-0.7
Novel to familiar place preference ratio1.72.22.4-1.51.5
Novelty place preference1.41.81.9-1.31.4
Time in novel zone, NPP test1.61.92.0-1.41.4
Total zone transitions, NPP test0.10.20.20.5-0.4
Total locomotion distance, NPP test1.01.41.51.2-1.1
Locomotion velocity, NPP test1.21.71.81.3-1.2
Intraocular pressure1.22.02.91.1-1.7
Delta distance traveled before/after self-admin4.44.85.32.1-2.3
Delta ambulatory time before/after self-admin2.44.24.61.9-2.1
Parametrial fat weight1.84.34.62.0-2.1
Pavlov. Cond. lever latency0.81.01.21.0-1.1
Pavlov. Cond. magazine entry latency1.72.22.4-1.41.5
Pavlov. Cond. change in total contacts2.83.03.2-1.71.8
Pavlov. Cond. index score2.93.74.1-1.82.0
Pavlov. Cond. latency score2.63.33.7-1.71.9
Pavlov. Cond. lever contacts0.91.11.3-1.01.1
Pavlov. Cond. magazine entry number1.21.61.81.2-1.3
Pavlov. Cond. intertrial magazine entries2.42.93.11.7-1.7
Pavlov. Cond. lever-magazine prob. diff.2.63.33.7-1.71.9
Pavlov. Cond. response bias0.60.70.9-0.80.9
Pavlov. Cond. lever latency1.82.63.3-1.81.4
Pavlov. Cond. magazine entry latency0.71.01.70.6-1.3
Pavlov. Cond. change in total contacts0.30.71.0-0.61.0
Pavlov. Cond. index score0.71.11.21.0-1.1
Pavlov. Cond. latency score0.50.80.90.9-1.0
Pavlov. Cond. lever contacts1.72.52.91.7-1.4
Pavlov. Cond. magazine entry number0.30.40.7-0.10.9
Pavlov. Cond. intertrial magazine entries1.22.63.21.8-1.4
Pavlov. Cond. lever-magazine prob. diff.0.50.70.80.8-0.9
Pavlov. Cond. response bias1.52.12.41.4-1.5
Time in closed arm before self-admin2.13.73.9-1.92.0
Time in closed arm after self-admin2.02.32.4-1.51.5
Time in open arm before self-admin0.50.60.7-0.70.8
Time in open arm after self-admin0.10.10.10.3-0.3
Bone: periosteal estimation0.10.30.4-0.60.5
Bone: periosteal perimeter0.91.71.9-1.41.2
Bone: post-yield work0.00.00.0-0.0-0.1
Progressive ratio test 1 active lever presses1.62.83.51.4-1.9
Progressive ratio test 1 breakpoint1.83.13.81.5-2.0
Progressive ratio test 1 inactive lever presses0.00.00.00.0-0.2
Progressive ratio test 2 active lever presses0.10.20.20.5-0.3
Progressive ratio test 2 breakpoint0.00.00.10.3-0.1
Progressive ratio test 2 inactive lever presses0.31.11.21.1-1.0
Incentive Sensitization - Responses0.30.71.0-0.71.0
Incentive Sensitization - Breakpoint0.40.91.2-0.81.1
Sum of active levers in priming session hrs 5-60.00.00.0-0.20.2
Progressive ratio0.00.10.10.3-0.3
Food seeking constrained by brief footshock0.60.70.90.8-0.9
Seeking ratio, punishment vs. effort0.00.00.00.1-0.1
Retroperitoneal fat weight3.113.714.23.8-3.6
Reaction time number correct0.10.50.70.5-0.8
Reaction time mean minus median0.00.10.2-0.4-0.3
Reaction time mean minus median AUC0.00.10.2-0.5-0.1
Reaction time num false alarms0.10.20.3-0.60.1
Reaction time num false alarms AUC0.10.30.4-0.60.4
Reaction time trials correct on left0.10.50.70.5-0.8
Reaction time trials on left0.10.50.70.5-0.8
Reaction time mean0.00.10.1-0.2-0.3
Reaction time mean AUC0.00.00.1-0.1-0.3
Median of all reaction times0.00.10.10.0-0.3
Reaction time omissions0.20.30.40.6-0.6
Reaction time false alarm rate0.91.21.3-1.21.0
Reaction time premature initiation rate1.32.02.21.5-1.3
Reaction time premature initiations1.03.13.31.8-1.7
Std. dev. reaction times0.10.20.3-0.6-0.2
Reaction time trials completed0.10.50.70.5-0.8
Reaction time trials AUC0.10.30.40.4-0.6
Run reversals in cocaine runway, females0.00.00.00.1-0.1
Run reversals in cocaine runway, males1.71.92.2-1.51.3
Latency to leave start box in cocaine runway0.50.70.9-0.71.0
Latency to leave start box in cocaine runway, F0.30.40.5-0.50.7
Latency to leave start box in cocaine runway, M0.60.60.8-0.60.9
Std. dev. time between licks in bursts0.40.80.91.0-0.8
Total sessions with >9 infusions0.30.40.60.8-0.5
Short access day 1 total inactive lever presses0.20.40.40.6-0.6
Short access day 10 total inactive lever presses0.00.20.4-0.20.6
Short access day 1 total infusions0.71.31.31.1-1.2
Short access day 10 total infusions0.00.10.10.3-0.1
Short access total infusions1.31.92.01.4-1.3
Short access day 1 locomotion0.10.10.10.3-0.3
Short access day 10 total locomotion0.00.00.00.1-0.2
Short access total locomotion0.30.50.50.7-0.7
One hour access (0.3 mA shock)0.10.10.1-0.40.2
Compulsive drug intake0.50.70.7-0.90.8
One hour access (shock baseline)0.00.00.0-0.0-0.0
Social response proportion0.50.71.00.6-1.0
Social responses0.00.00.00.1-0.0
Social time0.50.70.80.9-0.8
Soleus weight0.00.00.0-0.10.2
Bone: stiffness1.12.02.2-1.51.4
Tibialis anterior weight9.231.733.7-5.85.4
Time to tail flick, vehicle, before self-admin0.10.10.10.3-0.2
Time to tail flick, vehicle, after self-admin0.20.50.6-0.60.8
Time to tail flick, test, before self-admin0.30.30.4-0.60.5
Time to tail flick, test, after self-admin0.20.20.2-0.40.5
Delta time to tail flick, vehicle, before/after SA0.00.00.00.0-0.0
Delta time to tail flick, test, before/after SA0.00.00.00.10.1
Tibia length0.20.50.60.6-0.8
Ambulatory time before self-admin0.20.70.80.8-0.9
Ambulatory time after self-admin2.54.04.81.8-2.2
Bone: tissue strength0.10.20.2-0.40.3
Total heroin consumption0.40.50.60.6-0.8
Bone: trabecular number0.10.20.30.4-0.5
Bone: trabecular spacing0.20.30.4-0.60.6
Bone: trabecular thickness0.60.80.9-1.00.9
Bone: trabecular tissue density2.64.64.7-2.22.1
Water consumed over 24 hours0.91.81.81.3-1.3
Number of responses in last shaping day0.20.30.5-0.70.2