Patch foraging water rate 12 sec

Delay discounting using a sequential patch depletion procedure, water consumption rate during the last two sessions with an experimenter-imposed delay of 12 sec

Tags: Behavior · Delay discounting

Project: p50_david_dietz

3 loci · 3 genes with independent associations · 5 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr1 140610199 142008321 2 1 1.49e-07 1.63e-06 2.87e-01 Grm5
2 chr3 42193076 43591053 2 1 1.90e-07 5.07e-07 5.17e-02 Acvr1c
3 chr9 75969545 77365260 1 1 6.15e-25 2.28e-01 1.00e+00 Zfand2b

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 8.42 1 1 33.3 0 1.00e+00 Zfand2b
BMI without tail 53.65 1 1 33.3 0 1.00e+00 Zfand2b
Epididymis fat weight 111.28 1 1 33.3 0 1.00e+00 Zfand2b
Heart weight 71.7 1 1 33.3 0 1.00e+00 Zfand2b
Left kidney weight 14.91 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Right kidney weight 54.05 1 1 33.3 0 1.00e+00 Zfand2b
Tail length 64.62 2 1 33.3 0 1.00e+00 Acvr1c Zfand2b
Length with tail 3.52 2 0 0 0 1.00e+00 Acvr1c Zfand2b
Length without tail 77.43 1 1 33.3 0 1.00e+00 Zfand2b
Liver weight, right 9.91 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Parametrial fat weight 9.99 1 0 0 0 1.00e+00 Zfand2b
Retroperitoneal fat weight 7.53 1 0 0 0 1.00e+00 Zfand2b
Intraocular pressure 27.91 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Extensor digitorum longus weight 2.14 1 0 0 0 1.00e+00 Acvr1c
Soleus weight 3.41 1 0 0 0 1.00e+00 Acvr1c
Number of licking bursts 32.5 1 1 33.3 0 1.00e+00 Zfand2b
Food consumed during 24 hour testing period 10.61 2 0 0 0 1.00e+00 Acvr1c Zfand2b
Times rat made contact with spout 9.25 1 0 0 0 1.00e+00 Zfand2b
Mean time between licks in bursts 9.22 1 0 0 0 1.00e+00 Zfand2b
Mean num. licks in bursts 18.13 1 0 0 0 1.00e+00 Zfand2b
Std. dev. time between licks in bursts 12.12 1 0 0 0 1.00e+00 Zfand2b
Water consumed over 24 hours 34.33 1 1 33.3 0 1.00e+00 Zfand2b
Patch foraging indifference point 0 sec 11.8 1 0 0 0 1.00e+00 Zfand2b
Patch foraging indifference point AUC 24.2 1 1 33.3 0 1.00e+00 Zfand2b
Indifference point function ln k 54.42 1 1 33.3 0 1.00e+00 Zfand2b
Indifference point function log k 54.42 1 1 33.3 0 1.00e+00 Zfand2b
Patch foraging total patch changes 0 sec 23.48 1 1 33.3 0 1.00e+00 Zfand2b
Patch foraging total patch changes 18 sec 48.28 1 1 33.3 0 1.00e+00 Zfand2b
Patch foraging total patch changes 24 sec 77.61 1 1 33.3 0 1.00e+00 Zfand2b
Patch foraging total patch changes 6 sec 24.67 1 1 33.3 0 1.00e+00 Zfand2b
Patch foraging time to switch 0 sec 15.94 3 1 33.3 -0.99 7.67e-03 Acvr1c Grm5 Zfand2b
Patch foraging water rate 0 sec 13.61 3 1 33.3 1 2.52e-04 Acvr1c Grm5 Zfand2b
Patch foraging water rate 18 sec 18.71 3 1 33.3 0.89 4.16e-02 Acvr1c Grm5 Zfand2b
Patch foraging water rate 24 sec 9.01 2 0 0 0 1.00e+00 Grm5 Zfand2b
Patch foraging water rate 6 sec 17.39 3 1 33.3 0.99 1.00e-03 Acvr1c Grm5 Zfand2b
Locomotor activity 7.45 2 0 0 0 1.00e+00 Grm5 Zfand2b
Locomotor testing distance 19.63 2 1 33.3 0 1.00e+00 Acvr1c Zfand2b
Locomotor testing rearing 52.52 2 1 33.3 0 1.00e+00 Acvr1c Zfand2b
Light reinforcement 1 14.63 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Light reinforcement 2 16.87 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Reaction time number correct 114.79 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time mean minus median 179.03 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time mean minus median AUC 232.47 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time num false alarms 12.2 2 0 0 0 1.00e+00 Grm5 Zfand2b
Reaction time num false alarms AUC 17.17 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Reaction time trials correct on left 114.79 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time trials on left 106.69 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time mean 36.11 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time mean AUC 33.75 1 1 33.3 0 1.00e+00 Zfand2b
Median of all reaction times 17.65 1 0 0 0 1.00e+00 Zfand2b
Reaction time omissions 46.56 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time false alarm rate 15.06 1 0 0 0 1.00e+00 Grm5
Reaction time premature initiations 41.6 1 1 33.3 0 1.00e+00 Zfand2b
Std. dev. reaction times 72.92 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time trials completed 106.69 1 1 33.3 0 1.00e+00 Zfand2b
Reaction time trials AUC 108.76 1 1 33.3 0 1.00e+00 Zfand2b
Cocaine response after cond. corrected 12.71 1 0 0 0 1.00e+00 Zfand2b
Cocaine response after cond. not corrected 10.73 1 0 0 0 1.00e+00 Zfand2b
Saline control response 8.43 1 0 0 0 1.00e+00 Zfand2b
Condit. Reinf. lever presses 5.55 1 0 0 0 1.00e+00 Zfand2b
Conditioned reinforcement - actives 152.54 1 1 33.3 0 1.00e+00 Zfand2b
Conditioned reinforcement - inactives 135.63 1 1 33.3 0 1.00e+00 Zfand2b
Conditioned locomotion 13.93 1 0 0 0 1.00e+00 Zfand2b
Intermittent access intake day 1-15 change 156.77 1 1 33.3 0 1.00e+00 Zfand2b
Intermittent access intake escalation 117.41 1 1 33.3 0 1.00e+00 Zfand2b
Intermitt. access day 1 inactive lever presses 169.63 1 1 33.3 0 1.00e+00 Zfand2b
Intermitt. access day 15 inactive lever presses 294.26 1 1 33.3 0 1.00e+00 Zfand2b
Intermittent access day 1 total infusions 71.42 1 1 33.3 0 1.00e+00 Zfand2b
Intermittent access day 15 total infusions 35.39 1 1 33.3 0 1.00e+00 Zfand2b
Intermittent access terminal intake (last 3 days) 25.82 1 1 33.3 0 1.00e+00 Zfand2b
Intermittent access day 1 locomotion 26.47 1 1 33.3 0 1.00e+00 Zfand2b
Intermittent access day 15 total locomotion 93.08 1 1 33.3 0 1.00e+00 Zfand2b
Intermittent access total locomotion 12.43 1 0 0 0 1.00e+00 Zfand2b
Intermittent access standard deviation 442.51 1 1 33.3 0 1.00e+00 Zfand2b
Cocaine induced anxiety 125.35 1 1 33.3 0 1.00e+00 Zfand2b
Baseline Anxiety 200.09 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Incentive Sensitization - Responses 309.83 1 1 33.3 0 1.00e+00 Zfand2b
Incentive Sensitization - Breakpoint 300.45 1 1 33.3 0 1.00e+00 Zfand2b
Progressive ratio test 1 active lever presses 26.41 1 1 33.3 0 1.00e+00 Zfand2b
Progressive ratio test 1 breakpoint 19.19 1 0 0 0 1.00e+00 Zfand2b
Progressive ratio test 2 active lever presses 109.22 1 1 33.3 0 1.00e+00 Zfand2b
Progressive ratio test 2 breakpoint 106.65 1 1 33.3 0 1.00e+00 Zfand2b
Progressive ratio test 2 inactive lever presses 63.47 1 1 33.3 0 1.00e+00 Zfand2b
Short access day 1 total inactive lever presses 21.93 1 0 0 0 1.00e+00 Zfand2b
Short access day 10 total inactive lever presses 43.04 1 1 33.3 0 1.00e+00 Zfand2b
Short access day 1 locomotion 129.19 1 1 33.3 0 1.00e+00 Zfand2b
Short access day 10 total locomotion 432.47 1 1 33.3 0 1.00e+00 Zfand2b
Short access total locomotion 108.19 2 1 33.3 0 1.00e+00 Acvr1c Zfand2b
Compulsive drug intake 68.39 1 1 33.3 0 1.00e+00 Zfand2b
One hour access (0.3 mA shock) 22.58 1 0 0 0 1.00e+00 Zfand2b
Number of responses in last shaping day 67.75 1 1 33.3 0 1.00e+00 Zfand2b
Locomotion velocity, session 1 19.6 1 0 0 0 1.00e+00 Grm5
Locomotion velocity, session 2 6 1 0 0 0 1.00e+00 Grm5
Locomotion distance, session 3 7.94 1 0 0 0 1.00e+00 Grm5
Stereotopy head waving bouts, day 3 9.09 1 0 0 0 1.00e+00 Grm5
Locomotion velocity, session 7 6.56 1 0 0 0 1.00e+00 Grm5
Locomotion distance, session 7 5.61 1 0 0 0 1.00e+00 Grm5
Locomotion velocity, session 8 7.45 1 0 0 0 1.00e+00 Grm5
Total zone transitions, hab. session 1 5.37 1 0 0 0 1.00e+00 Grm5
Total locomotion distance, hab. session 1 30.92 1 1 33.3 0 1.00e+00 Grm5
Locomotion velocity, hab. session 1 30.89 1 1 33.3 0 1.00e+00 Grm5
Total locomotion distance, hab. session 2 37.49 1 1 33.3 0 1.00e+00 Grm5
Locomotion velocity, hab. session 2 35.23 1 1 33.3 0 1.00e+00 Grm5
Total locomotion distance, NPP test 38.3 1 1 33.3 0 1.00e+00 Grm5
Locomotion velocity, NPP test 37.66 1 1 33.3 0 1.00e+00 Grm5
Distance traveled after self-admin 8.9 1 0 0 0 1.00e+00 Zfand2b
Delta time in open arm before/after self-admin 26.67 1 0 0 0 1.00e+00 Zfand2b
Active lever presses in extinction session 6 26.41 1 0 0 0 1.00e+00 Zfand2b
Delta ambulatory time before/after self-admin 6.19 1 0 0 0 1.00e+00 Zfand2b
Time in closed arm before self-admin 44.32 1 1 33.3 0 1.00e+00 Zfand2b
Time in open arm before self-admin 24.67 1 0 0 0 1.00e+00 Zfand2b
Sum of active levers in priming session hrs 5-6 6.97 1 0 0 0 1.00e+00 Zfand2b
Time to tail flick, vehicle, after self-admin 75.62 1 1 33.3 0 1.00e+00 Zfand2b
Time to tail flick, test, before self-admin 10.68 1 0 0 0 1.00e+00 Zfand2b
Delta time to tail flick, vehicle, before/after SA 74.6 1 1 33.3 0 1.00e+00 Zfand2b
Ambulatory time before self-admin 25.36 1 0 0 0 1.00e+00 Zfand2b
Area under the delay curve 31.15 1 1 33.3 0 1.00e+00 Zfand2b
Delay disc. indifference point, 16s delay 69.03 1 1 33.3 0 1.00e+00 Zfand2b
Delay disc. indifference point, 24s delay 27.43 1 0 0 0 1.00e+00 Zfand2b
Delay disc. indifference point, 8s delay 74.24 1 1 33.3 0 1.00e+00 Zfand2b
Delay discount exponential model param 16.14 1 0 0 0 1.00e+00 Zfand2b
Delay discount hyperbolic model param 15.89 1 0 0 0 1.00e+00 Zfand2b
Fecal boli incidents, locomotor time 1 176.47 1 1 33.3 0 1.00e+00 Zfand2b
Time >=10cm from walls, locomotor time 1 79.04 1 1 33.3 0 1.00e+00 Zfand2b
Bouts of movement, locomotor time 1 6.58 2 0 0 0 1.00e+00 Acvr1c Zfand2b
Total resting periods, locomotor time 1 10.12 1 0 0 0 1.00e+00 Acvr1c
Rest time, locomotor task time 1 10.41 2 0 0 0 1.00e+00 Acvr1c Zfand2b
Vertical activity count, locomotor time 1 97.7 1 1 33.3 0 1.00e+00 Zfand2b
Bouts of movement, locomotor time 2 23.9 1 0 0 0 1.00e+00 Zfand2b
Total resting periods, locomotor time 2 36.28 1 1 33.3 0 1.00e+00 Zfand2b
Rest time, locomotor task time 2 44.91 1 1 33.3 0 1.00e+00 Zfand2b
Distance moved, locomotor task time 2 83.87 1 1 33.3 0 1.00e+00 Zfand2b
Vertical activity count, locomotor time 2 9.85 2 0 0 0 1.00e+00 Grm5 Zfand2b
Weight adjusted by age 9.91 1 0 0 0 1.00e+00 Zfand2b
Seeking ratio, delayed vs. immediate footshock 8.74 1 0 0 0 1.00e+00 Zfand2b
Locomotion in novel chamber post-restriction 14.04 1 0 0 0 1.00e+00 Zfand2b
Food seeking constrained by brief footshock 14.98 1 0 0 0 1.00e+00 Zfand2b
Run reversals in cocaine runway, females 36.45 1 1 33.3 0 1.00e+00 Zfand2b
Latency to leave start box in cocaine runway 20.7 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Latency to leave start box in cocaine runway, F 15.11 2 1 33.3 0 1.00e+00 Grm5 Zfand2b
Latency to leave start box in cocaine runway, M 10.15 1 0 0 0 1.00e+00 Grm5

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.5
Adipose alternative TSS 0 0 1.46
Adipose gene expression 0 0 1.48
Adipose isoform ratio 0 0 1.52
Adipose intron excision ratio 0 0 1.62
Adipose mRNA stability 0 0 1.5
BLA alternative polyA 0 0 1.65
BLA alternative TSS 0 0 1.53
BLA gene expression 0 0 1.52
BLA isoform ratio 1 0 1.62
BLA intron excision ratio 0 0 1.56
BLA mRNA stability 0 0 1.52
Brain alternative polyA 0 0 1.53
Brain alternative TSS 0 0 1.55
Brain gene expression 2 0 1.48
Brain isoform ratio 0 0 1.56
Brain intron excision ratio 1 0 1.56
Brain mRNA stability 0 0 1.48
Eye alternative polyA 0 0 1.44
Eye alternative TSS 0 0 1.28
Eye gene expression 0 0 1.46
Eye isoform ratio 0 0 1.59
Eye intron excision ratio 0 0 1.43
Eye mRNA stability 0 0 1.41
IL alternative polyA 0 0 1.58
IL alternative TSS 0 0 1.42
IL gene expression 0 0 1.5
IL isoform ratio 0 0 1.77
IL intron excision ratio 0 0 1.58
IL mRNA stability 0 0 1.62
LHb alternative polyA 0 0 1.5
LHb alternative TSS 0 0 1.68
LHb gene expression 0 0 1.52
LHb isoform ratio 0 0 1.65
LHb intron excision ratio 0 0 1.47
LHb mRNA stability 0 0 1.57
Liver alternative polyA 0 0 1.49
Liver alternative TSS 0 0 1.52
Liver gene expression 0 0 1.5
Liver isoform ratio 0 0 1.46
Liver intron excision ratio 0 0 1.53
Liver mRNA stability 0 0 1.51
NAcc alternative polyA 0 0 1.61
NAcc alternative TSS 0 0 1.48
NAcc gene expression 0 0 1.56
NAcc isoform ratio 0 0 1.58
NAcc intron excision ratio 0 0 1.52
NAcc mRNA stability 0 0 1.56
OFC alternative polyA 0 0 1.54
OFC alternative TSS 0 0 1.57
OFC gene expression 0 0 1.48
OFC isoform ratio 0 0 1.62
OFC intron excision ratio 0 0 1.7
OFC mRNA stability 0 0 1.59
PL alternative polyA 0 0 1.65
PL alternative TSS 0 0 1.48
PL gene expression 0 0 1.52
PL isoform ratio 0 0 1.62
PL intron excision ratio 1 0 1.54
PL mRNA stability 0 0 1.52
pVTA alternative polyA 0 0 1.58
pVTA alternative TSS 0 0 1.54
pVTA gene expression 0 0 1.51
pVTA isoform ratio 0 0 1.58
pVTA intron excision ratio 0 0 1.64
pVTA mRNA stability 0 0 1.6
RMTg alternative polyA 0 0 1.41
RMTg alternative TSS 0 0 1.4
RMTg gene expression 0 0 1.53
RMTg isoform ratio 0 0 1.35
RMTg intron excision ratio 0 0 1.47
RMTg mRNA stability 0 0 1.63