Hub : Genes

Bbs7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Bbs7 0.08 0.05 2.8e-11 0.03 0.06 0.06 0.05 1.5e-05 4.9e-10 4.0e-09 1.2e-08
2 Liver mRNA stability Bbs7 0.09 0.05 3.2e-08 0.06 0.05 0.05 0.05 4.6e-07 1.5e-06 4.3e-06 4.1e-06
3 PL gene expression Bbs7 0.12 0.08 6.2e-08 0.07 0.06 0.06 0.06 4.8e-08 1.6e-07 1.8e-07 1.4e-07
4 Brain gene expression Bbs7 0.2 0.11 5.2e-08 0.09 0.07 0.09 0.08 1.8e-08 1.6e-07 2.0e-08 8.2e-08
5 Liver gene expression Bbs7 0.33 0.13 0.0e+00 0.18 0.22 0.19 0.21 2.1e-19 1.4e-23 4.6e-21 2.7e-23
6 pVTA gene expression Bbs7 0.16 0.08 3.1e-11 0.07 0.13 0.13 0.13 3.6e-06 1.4e-10 2.5e-10 2.1e-10
7 LHb mRNA stability Bbs7 0.34 0.15 2.6e-05 0.13 0.19 0.12 0.16 6.3e-04 2.9e-05 8.3e-04 1.4e-04
8 Brain mRNA stability Bbs7 0.26 0.11 0.0e+00 0.27 0.28 0.28 0.28 5.5e-25 4.4e-26 4.4e-26 8.0e-26
9 IC mRNA stability Bbs7 0.08 0.07 8.8e-03 0.07 0.04 0.02 0.06 7.5e-04 9.5e-03 6.0e-02 1.8e-03
10 IL mRNA stability Bbs7 0.19 0.13 3.5e-03 0.15 0.11 0.13 0.14 2.3e-04 1.5e-03 4.7e-04 2.5e-04
11 BLA mRNA stability Bbs7 0.29 0.18 5.0e-08 0.14 0.14 0.1 0.15 8.5e-08 4.7e-08 3.9e-06 3.1e-08
12 OFC mRNA stability Bbs7 0.33 0.14 9.3e-06 0.2 0.21 0.14 0.22 2.0e-05 1.0e-05 2.9e-04 5.1e-06
13 pVTA mRNA stability Bbs7 0.12 0.07 3.7e-08 0.1 0.1 0.1 0.1 1.9e-08 3.6e-08 9.5e-09 2.1e-08
14 NAcc mRNA stability Bbs7 0.09 0.06 4.9e-10 0.06 0.06 0.06 0.06 1.1e-09 7.6e-10 3.1e-09 4.2e-09
15 PL mRNA stability Bbs7 0.3 0.13 0.0e+00 0.19 0.2 0.19 0.19 1.8e-20 1.6e-21 2.2e-20 2.6e-20
16 IL gene expression Bbs7 0.31 0.16 2.6e-04 0.06 0.11 0.13 0.09 1.5e-02 1.2e-03 5.7e-04 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.20.40.9-0.40.0-0.00.00.3-0.4-0.5-0.6-0.8-0.8-0.7-0.6-0.6-0.6-0.91.0
Area under the delay curve0.70.82.4-1.51.3-1.3-1.01.50.2-0.2-0.5-0.9-0.9-0.4-0.4-0.4-0.3-0.51.1
BMI with tail2.910.218.1-3.74.1-4.1-4.33.43.73.22.82.52.53.02.72.93.02.5-0.3
BMI without tail1.23.68.4-2.82.8-2.8-2.92.52.11.71.30.90.91.41.31.51.51.20.5
Body weight2.812.222.4-4.14.1-4.1-4.73.64.33.93.32.42.23.43.13.33.62.8-1.4
Weight adjusted by age0.00.10.30.4-0.20.20.2-0.3-0.3-0.3-0.2-0.1-0.3-0.1-0.1-0.1-0.20.00.5
Bone surface0.61.01.8-0.61.3-1.3-1.10.51.11.11.00.80.91.11.11.11.00.9-0.5
Bone volume0.00.00.1-0.20.4-0.4-0.2-0.10.20.30.2-0.1-0.00.20.30.20.1-0.2-0.1
Breakpoint value in progressive ratio session1.21.42.2-1.11.4-1.4-1.51.21.41.21.11.21.01.11.11.11.21.1-0.1
Number of licking bursts1.32.03.6-1.71.7-1.7-1.91.31.81.71.30.90.91.31.51.31.40.9-0.5
Context. condit. distance diff. score2.12.64.7-0.1-1.01.01.1-0.2-1.6-1.6-1.8-2.0-2.0-1.8-1.8-1.8-1.9-2.21.9
Locomotion velocity, session 12.12.34.00.30.7-0.7-0.7-0.41.51.71.92.02.01.81.91.81.81.8-1.5
Locomotion distance, session 13.24.05.9-0.51.6-1.6-1.60.52.12.32.32.42.42.32.42.32.32.3-1.7
Locomotion velocity, session 22.42.85.40.30.5-0.5-0.6-0.61.62.02.12.32.31.92.12.01.91.8-1.6
Locomotion distance, session 21.82.54.30.20.9-0.9-0.7-0.51.51.92.02.12.11.82.01.91.81.7-1.6
Locomotion velocity, session 30.00.00.10.2-0.00.0-0.1-0.10.20.20.20.30.30.20.00.20.30.3-0.3
Locomotion distance, session 30.10.10.70.3-0.10.10.1-0.50.20.40.40.30.30.30.40.30.30.2-0.9
Stereotopy head waving bouts, day 30.91.02.60.80.1-0.1-0.0-0.80.71.01.21.21.31.21.01.21.11.2-1.6
Stereotopy head waving duration, day 30.10.10.3-0.20.5-0.5-0.50.40.40.20.30.30.30.40.10.40.40.5-0.5
Locomotion velocity, session 71.01.11.90.30.3-0.3-0.3-0.41.01.21.31.31.31.21.21.21.21.2-1.4
Locomotion distance, session 70.91.22.71.4-1.61.61.6-1.6-1.2-0.7-0.6-0.5-0.5-0.8-0.7-0.8-0.9-1.00.3
Stereotopy head waving bouts, day 70.91.01.6-0.30.9-0.9-0.80.11.11.31.21.01.11.11.01.11.10.9-1.3
Stereotopy head waving duration, day 70.80.91.6-0.40.9-0.9-0.90.31.11.11.10.91.01.01.01.01.10.9-1.3
Locomotion velocity, session 80.30.31.4-1.20.8-0.8-0.81.00.30.1-0.2-0.2-0.1-0.1-0.1-0.1-0.1-0.30.8
Locomotion distance, session 80.10.10.3-0.50.4-0.4-0.30.10.30.40.20.1-0.00.10.20.20.1-0.30.3
Degree of sensitization distance1.71.83.11.3-1.81.81.8-1.4-1.5-1.2-1.1-0.9-0.9-1.3-1.2-1.2-1.4-1.31.0
Degree of sensitization stereotypy0.50.61.1-0.81.1-1.1-1.00.70.90.80.60.40.50.60.50.60.70.5-0.7
Conditioned locomotion2.02.43.21.4-1.71.71.7-1.3-1.8-1.7-1.5-1.4-1.5-1.5-1.6-1.5-1.6-1.51.3
Cocaine response after cond. corrected1.72.13.6-0.0-0.80.80.90.0-1.5-1.7-1.7-1.8-1.8-1.7-1.9-1.7-1.7-1.81.1
Cocaine response after cond. not corrected0.50.61.40.3-0.60.60.6-0.1-0.9-1.0-0.9-1.0-0.9-0.9-1.2-0.9-0.9-0.8-0.1
Cocaine response before conditioning2.42.86.00.11.0-1.0-1.00.21.61.61.91.92.01.91.81.92.02.3-2.4
Saline control response2.02.74.5-0.51.1-1.1-1.40.61.91.81.91.81.62.11.91.92.02.1-1.5
Bone: connectivity density0.91.52.7-1.21.6-1.6-1.51.11.41.31.10.90.91.11.31.21.21.00.1
Bone: cortical apparent density0.60.82.91.4-1.41.41.5-1.7-0.8-0.3-0.20.0-0.1-0.40.0-0.4-0.5-0.6-0.2
Bone: cortical area0.50.81.4-0.91.2-1.2-1.10.71.01.00.90.70.80.90.70.90.90.7-0.5
Bone: cortical porosity0.91.03.7-1.21.1-1.1-0.91.9-0.1-1.0-1.0-0.8-0.8-0.8-0.9-0.6-0.5-0.11.4
Bone: cortical porosity0.91.04.0-1.31.2-1.2-1.12.00.0-0.9-0.9-0.8-0.7-0.6-0.8-0.5-0.30.11.3
Bone: cortical thickness0.10.10.3-0.30.5-0.5-0.20.5-0.1-0.4-0.4-0.5-0.4-0.3-0.3-0.3-0.2-0.1-0.1
Bone: cortical thickness0.50.61.8-0.60.9-0.9-0.80.50.80.70.70.40.50.70.90.60.70.5-1.3
Bone: cortical tissue density0.60.83.01.4-1.41.41.4-1.7-0.8-0.2-0.10.1-0.1-0.30.1-0.4-0.5-0.5-0.3
Condit. Reinf. active minus inactive responses0.70.71.1-0.80.7-0.7-0.70.71.01.00.90.80.90.91.10.90.90.8-0.8
Condit. Reinf. active-inactive response ratio0.20.21.3-1.10.7-0.7-0.61.10.40.1-0.1-0.3-0.10.00.1-0.10.0-0.1-0.0
Condit. Reinf. active responses3.13.95.5-1.62.0-2.0-1.91.52.42.22.11.81.92.12.32.12.12.0-1.5
Condit. Reinf. inactive responses5.87.09.9-1.22.4-2.4-2.41.23.02.92.92.82.82.93.23.03.03.1-2.0
Incentive salience index mean0.70.91.4-0.70.7-0.7-0.80.61.11.11.10.91.01.11.21.01.00.9-1.0
Condit. Reinf. lever presses1.41.92.8-0.30.8-0.8-0.90.31.51.61.71.61.71.61.71.61.61.6-1.4
Condit. Reinf. active minus inactive responses1.31.73.8-0.81.4-1.4-1.20.91.41.21.21.31.31.21.21.21.31.4-1.9
Condit. Reinf. active-inactive response ratio0.30.40.8-0.1-0.20.20.30.1-0.6-0.8-0.8-0.8-0.8-0.9-0.8-0.8-0.7-0.7-0.0
Condit. Reinf. active responses4.25.99.3-1.12.3-2.3-2.11.22.62.52.62.62.62.62.62.62.72.7-3.0
Condit. Reinf. inactive responses9.412.115.3-1.73.2-3.2-3.21.73.93.83.83.63.73.93.93.83.93.8-3.5
Condit. Reinf. lever presses0.91.22.7-1.61.5-1.5-1.51.51.31.00.80.70.70.70.80.80.80.6-0.7
Condit. Reinf. lever reinforcers received3.75.28.1-1.12.1-2.1-2.01.12.52.42.42.42.42.42.52.42.52.5-2.9
Conditioned reinforcement - actives0.71.13.01.6-1.41.41.0-1.7-0.10.50.81.21.70.60.50.60.50.6-1.0
Conditioned reinforcement - inactives0.60.82.41.1-1.51.51.2-1.0-1.0-0.7-0.7-0.3-0.0-0.8-0.7-0.8-0.7-0.6-0.4
Conditioned locomotion1.21.54.00.8-0.70.70.5-1.40.71.41.51.72.01.41.31.31.00.9-1.1
Patch foraging indifference point 0 sec0.81.45.5-2.31.5-1.5-1.92.11.30.90.50.4-0.00.70.40.50.70.30.8
Patch foraging indifference point AUC0.40.61.20.20.3-0.3-0.2-0.20.80.91.00.90.81.01.11.10.91.0-0.9
Delay disc. indifference point, 0s delay0.40.41.11.0-0.20.20.6-1.00.20.50.70.90.70.70.70.70.50.7-0.2
Delay disc. indifference point, 16s delay0.50.52.3-1.21.5-1.5-0.81.00.50.20.0-0.3-0.60.10.10.20.1-0.10.3
Delay disc. indifference point, 2s delay0.40.51.7-1.31.0-1.0-1.01.30.40.1-0.2-0.7-0.6-0.0-0.1-0.20.0-0.20.7
Delay disc. indifference point, 24s delay0.70.82.3-0.20.1-0.10.40.1-0.8-0.9-1.0-1.1-1.2-1.1-0.9-0.9-1.0-1.01.5
Delay disc. indifference point, 4s delay0.90.92.7-1.61.6-1.6-1.51.71.00.60.30.1-0.00.50.40.50.60.50.3
Delay disc. indifference point, 8s delay0.81.02.3-0.60.0-0.0-0.00.6-0.7-1.0-1.2-1.5-1.4-1.1-1.1-1.2-1.0-1.11.3
Indifference point function ln k0.91.73.0-0.8-0.30.30.10.9-1.0-1.3-1.6-1.5-1.4-1.6-1.7-1.6-1.4-1.51.7
Indifference point function log k0.91.73.0-0.8-0.30.30.10.9-1.0-1.3-1.6-1.5-1.4-1.6-1.7-1.6-1.4-1.51.7
Patch foraging total patch changes 0 sec0.71.34.6-2.21.4-1.4-1.82.11.20.80.50.40.10.70.50.50.70.50.8
Patch foraging total patch changes 12 sec0.10.10.40.2-0.50.50.4-0.2-0.1-0.10.0-0.3-0.60.00.00.0-0.1-0.0-0.1
Patch foraging total patch changes 18 sec0.40.71.1-0.90.6-0.6-0.90.81.00.90.81.00.70.90.80.80.80.7-0.3
Patch foraging total patch changes 24 sec1.42.34.1-2.01.8-1.8-2.01.81.81.61.30.90.71.41.31.31.51.1-1.1
Patch foraging total patch changes 6 sec0.71.02.7-1.61.2-1.2-1.41.61.20.80.70.20.10.90.60.80.90.80.3
Patch foraging time to switch 0 sec0.51.01.71.1-1.11.11.3-1.2-1.2-0.9-0.8-0.7-0.7-0.9-0.9-0.8-1.0-1.00.0
Patch foraging water rate 0 sec0.10.10.5-0.60.4-0.4-0.60.70.3-0.00.0-0.3-0.30.10.00.00.10.2-0.1
Patch foraging water rate 12 sec0.20.40.8-0.00.2-0.2-0.60.20.70.70.70.60.80.80.70.60.80.9-0.8
Patch foraging water rate 18 sec0.50.81.6-0.50.6-0.6-0.90.41.01.01.00.71.00.90.90.91.00.9-1.3
Patch foraging water rate 24 sec0.60.81.3-0.30.7-0.7-0.90.21.11.11.10.80.71.11.11.01.11.0-0.5
Patch foraging water rate 6 sec0.10.10.3-0.10.1-0.1-0.50.20.40.30.30.30.40.30.30.20.40.6-0.6
Seeking ratio, delayed vs. immediate footshock1.41.73.7-1.91.8-1.8-1.91.81.31.00.70.90.90.90.70.80.90.71.1
Distance traveled before self-admin1.01.43.2-1.41.8-1.8-1.41.11.31.11.00.20.11.11.11.21.00.8-0.9
Distance traveled after self-admin2.42.94.2-1.62.1-2.1-1.71.12.02.01.81.51.41.81.91.91.71.4-0.9
Extensor digitorum longus weight2.710.420.6-4.44.5-4.5-4.44.23.83.02.32.11.92.62.62.62.82.20.6
Bone: elastic displacement3.94.57.6-0.7-0.70.70.70.9-2.0-2.5-2.8-2.4-2.4-2.7-2.6-2.6-2.5-2.52.7
Bone: elastic work3.44.46.90.4-1.31.31.5-0.2-2.3-2.6-2.6-2.5-2.4-2.6-2.6-2.5-2.5-2.31.6
Bone: endosteal estimation1.43.15.3-1.31.5-1.5-1.70.72.12.32.12.02.12.01.72.11.91.4-0.7
Bone: endosteal perimeter1.02.24.5-0.40.8-0.8-1.00.01.61.91.92.02.11.81.61.91.71.5-0.5
Epididymis fat weight1.44.79.8-3.02.8-2.8-3.12.92.62.11.71.21.21.81.61.72.01.5-0.6
Delta time in closed arm before/after self-admin0.40.30.6-0.70.5-0.5-0.80.70.80.60.60.10.00.70.60.60.70.6-0.5
Delta time in open arm before/after self-admin1.01.01.70.4-1.01.00.5-0.1-1.1-1.2-1.2-1.0-1.3-1.2-1.3-1.3-1.0-0.90.5
Diff in mean of infusions in LGA sessions0.20.31.2-1.10.8-0.8-0.60.90.20.0-0.2-0.2-0.4-0.2-0.1-0.1-0.2-0.40.2
Delay discount exponential model param0.80.92.41.6-1.31.30.9-1.5-0.10.40.71.11.00.50.60.50.40.6-1.3
Extinction: sum of active levers before priming0.40.51.20.4-0.20.2-0.0-0.50.50.70.91.00.60.80.80.70.70.7-1.1
Active lever presses in extinction session 60.10.10.2-0.50.3-0.3-0.40.50.0-0.1-0.2-0.3-0.2-0.2-0.2-0.2-0.1-0.3-0.1
Bone: final force2.13.35.8-1.82.4-2.4-2.21.82.11.71.61.21.21.81.61.81.81.7-1.2
Bone: final moment1.72.85.4-1.92.3-2.3-2.21.91.91.51.40.90.91.61.41.51.61.4-0.8
Food consumed during 24 hour testing period0.10.10.4-0.70.3-0.3-0.30.30.40.50.30.30.30.10.40.20.1-0.20.6
Glucose0.10.21.00.6-0.50.50.4-0.6-0.1-0.00.20.20.30.20.00.10.00.2-1.0
Heart weight1.72.67.0-2.52.2-2.2-2.52.61.91.20.90.60.81.11.01.01.31.1-0.1
Delay discount hyperbolic model param0.80.92.61.6-1.31.31.0-1.6-0.20.30.71.11.00.50.50.50.40.5-1.2
Intermittent access intake day 1-15 change0.81.63.01.7-1.71.71.7-1.5-1.5-1.2-1.1-0.1-0.1-1.1-1.1-1.1-1.2-0.90.8
Intermittent access intake escalation0.51.12.21.5-1.51.51.5-1.3-1.2-1.0-0.80.0-0.0-0.8-0.8-0.9-0.9-0.70.5
Intermittent access intake escalation 20.50.51.10.8-1.01.01.0-0.8-0.9-0.7-0.6-0.10.0-0.6-0.6-0.6-0.7-0.60.8
Intermitt. access day 1 inactive lever presses0.10.20.40.5-0.70.70.5-0.4-0.5-0.5-0.5-0.5-0.1-0.5-0.4-0.5-0.5-0.40.0
Intermitt. access day 15 inactive lever presses0.10.30.80.7-0.40.40.30.0-0.6-0.9-0.7-0.00.2-0.6-0.6-0.6-0.5-0.10.8
Intermitt. access escalation Index0.20.30.60.2-0.70.70.30.2-0.4-0.6-0.6-0.7-0.8-0.5-0.7-0.7-0.3-0.2-0.6
Intermittent access day 1 total infusions1.52.46.62.5-1.81.81.6-2.6-0.00.81.21.51.51.00.91.00.81.0-2.3
Intermittent access day 15 total infusions1.62.37.02.6-2.42.41.9-2.6-0.60.20.61.41.40.40.30.30.20.5-1.8
Intermittent access terminal intake (last 3 days)1.92.59.02.9-2.42.42.2-3.0-0.9-0.10.41.21.30.20.10.1-0.10.3-1.0
Intermittent access total infusions2.73.26.42.1-1.51.50.9-2.20.71.41.92.22.31.81.61.61.51.7-2.5
Intermittent access day 1 locomotion1.82.34.21.2-0.70.70.4-1.70.91.61.92.02.01.71.61.71.41.4-1.9
Intermittent access day 15 total locomotion0.71.33.70.5-1.01.00.2-1.10.61.41.31.91.91.20.91.00.90.7-0.9
Intermittent access total locomotion2.02.44.90.8-0.90.90.2-1.51.01.92.02.22.21.91.61.71.51.3-1.5
Intermittent access standard deviation0.10.20.50.3-0.50.50.20.1-0.5-0.7-0.7-0.4-0.3-0.5-0.7-0.7-0.5-0.30.5
Left kidney weight0.10.72.9-1.71.0-1.0-1.41.50.50.2-0.1-0.7-0.8-0.2-0.2-0.2-0.1-0.50.6
Right kidney weight0.62.910.4-3.22.6-2.6-2.83.21.40.70.2-0.5-0.40.20.20.30.60.10.8
Cocaine induced anxiety0.60.93.5-1.41.3-1.3-1.21.20.80.70.41.00.50.40.50.50.50.31.9
Post-drug Anxiety1.01.03.2-1.51.6-1.6-1.51.80.90.40.20.50.30.30.30.30.50.51.3
Baseline Anxiety0.40.51.60.5-0.30.30.40.0-0.6-0.9-0.7-1.3-0.9-0.7-0.7-0.6-0.5-0.4-1.0
Tail length0.00.20.5-0.70.5-0.5-0.70.60.30.20.0-0.5-0.70.00.00.10.2-0.0-0.1
Length with tail0.52.24.6-1.81.6-1.6-2.11.61.91.71.50.50.41.41.31.41.61.1-1.3
Length without tail1.85.810.1-2.82.6-2.6-3.22.42.92.72.41.51.32.42.22.32.51.9-2.0
Times rat made contact with spout0.20.20.70.4-0.60.60.5-0.8-0.10.30.20.50.4-0.00.20.1-0.1-0.30.4
Lifetime Intake2.53.06.62.1-1.51.50.9-2.20.61.31.82.12.21.71.51.51.41.6-2.6
Liver weight, left0.20.30.80.8-0.30.30.3-0.90.20.50.60.80.60.50.60.50.40.4-0.8
Liver weight, right0.20.30.60.4-0.70.70.4-0.3-0.6-0.6-0.6-0.6-0.3-0.6-0.7-0.7-0.6-0.50.8
Locomotor activity0.10.10.4-0.10.5-0.5-0.10.60.1-0.4-0.2-0.00.0-0.1-0.10.00.00.4-0.2
Locomotor testing distance2.54.56.7-1.92.6-2.6-2.52.32.41.81.81.92.12.11.92.12.12.3-1.1
Locomotor testing rearing0.10.20.9-0.50.7-0.7-0.71.00.4-0.10.00.10.20.20.10.20.30.6-0.3
Locomotion in novel chamber1.11.42.1-1.41.2-1.2-1.41.11.51.31.21.00.71.21.21.21.20.9-0.6
Locomotion in novel chamber post-restriction0.10.20.8-0.50.9-0.9-0.50.70.40.10.10.20.00.20.30.20.30.4-0.4
Fecal boli incidents, locomotor time 11.11.62.71.3-1.51.51.6-1.1-1.5-1.3-1.2-1.6-0.8-1.2-1.1-1.4-1.2-1.20.3
Change in fecal boli incidents, locomotor task1.91.93.1-0.91.3-1.3-1.40.71.61.61.61.81.11.61.51.61.51.4-0.7
Time >=10cm from walls, locomotor time 10.30.30.60.4-0.00.00.1-0.40.40.50.70.80.30.60.70.60.60.7-0.6
Bouts of movement, locomotor time 11.31.52.71.1-1.61.61.5-1.0-1.4-1.2-1.2-0.7-0.5-1.4-1.3-1.4-1.2-1.11.1
Total resting periods, locomotor time 12.62.94.41.3-2.12.11.9-1.2-2.0-1.7-1.8-1.3-1.2-1.9-1.8-2.0-1.7-1.61.3
Rest time, locomotor task time 11.31.72.81.3-1.71.71.6-1.4-1.6-1.3-1.1-0.5-0.8-1.3-1.3-1.1-1.4-1.30.6
Distance moved, locomotor task time 11.62.33.5-1.31.6-1.6-1.61.11.91.81.71.11.21.81.71.51.71.5-0.9
Vertical activity count, locomotor time 10.92.13.7-1.81.8-1.8-1.91.61.81.61.30.60.81.41.41.21.51.1-0.5
Time >=10cm from walls, locomotor time 20.20.20.80.9-0.60.60.9-0.9-0.4-0.2-0.10.3-0.0-0.2-0.0-0.1-0.2-0.10.1
Bouts of movement, locomotor time 21.82.94.51.4-1.71.71.8-1.1-2.1-2.0-2.0-1.1-0.9-2.1-2.0-1.9-2.0-1.71.0
Total resting periods, locomotor time 21.32.23.61.1-1.31.31.4-0.8-1.8-1.9-1.8-1.0-0.9-1.9-1.8-1.7-1.8-1.50.9
Rest time, locomotor task time 20.30.30.70.0-0.30.30.30.1-0.7-0.7-0.8-0.4-0.6-0.9-0.8-0.7-0.7-0.60.4
Distance moved, locomotor task time 21.41.72.8-0.51.1-1.1-0.90.41.51.51.61.31.31.71.61.51.51.4-0.8
Vertical activity count, locomotor time 21.72.44.4-0.20.9-0.9-0.8-0.01.71.92.11.61.62.12.02.01.91.7-1.2
Light reinforcement 10.10.20.60.8-0.60.60.4-0.3-0.4-0.5-0.3-0.4-0.5-0.1-0.1-0.3-0.10.3-0.8
Light reinforcement 20.20.30.90.9-0.90.90.6-0.8-0.6-0.3-0.2-0.2-0.3-0.4-0.2-0.3-0.3-0.20.1
Bone: marrow area1.43.15.4-1.41.6-1.6-1.80.82.12.32.12.02.01.91.72.11.91.4-0.6
Bone: maximum diameter0.71.42.3-0.71.1-1.1-1.00.31.31.51.41.41.51.31.21.51.21.0-0.6
Bone: maximum force0.61.12.1-0.91.5-1.5-1.20.81.21.11.00.70.71.11.01.11.00.9-0.7
Bone: maximum moment0.50.82.0-1.11.4-1.4-1.10.91.00.90.70.40.40.80.80.80.80.6-0.3
Mean time between licks in bursts0.00.10.70.2-0.30.30.3-0.3-0.2-0.1-0.2-0.4-0.4-0.2-0.0-0.3-0.2-0.4-0.8
Mean num. licks in bursts1.21.83.41.5-1.81.81.9-1.4-1.6-1.5-1.2-0.6-0.6-1.2-1.3-1.1-1.4-1.00.8
Cd content in liver0.50.52.11.4-1.11.11.1-1.4-0.6-0.3-0.10.30.4-0.10.0-0.1-0.2-0.00.0
Co content in liver0.50.61.3-1.11.1-1.1-1.11.00.80.60.40.40.50.40.60.50.50.40.6
Cu content in liver0.10.10.3-0.00.2-0.2-0.2-0.20.40.60.50.50.40.30.50.40.40.2-0.0
Fe content in liver0.30.30.60.3-0.40.40.4-0.2-0.6-0.7-0.7-0.8-0.7-0.6-0.6-0.7-0.6-0.5-0.2
K content in liver1.00.91.60.7-1.01.01.1-0.8-1.1-0.9-0.8-1.3-1.3-1.0-0.9-0.9-1.0-1.1-0.2
Mg content in liver0.90.92.00.1-0.80.80.8-0.3-1.0-0.9-1.0-1.4-1.4-1.1-1.0-1.1-1.1-1.30.1
Mn content in liver1.61.82.41.1-1.51.51.5-1.0-1.6-1.5-1.3-1.2-1.2-1.4-1.5-1.3-1.4-1.20.6
Na content in liver1.21.33.0-0.20.8-0.8-0.8-0.01.21.41.41.00.91.31.41.31.31.2-1.7
Rb content in liver0.50.62.5-1.30.9-0.9-0.91.60.2-0.4-0.5-0.9-0.9-0.3-0.3-0.4-0.2-0.1-0.3
Se content in liver1.21.44.02.0-1.81.81.8-2.0-1.3-0.9-0.5-0.3-0.3-0.7-0.8-0.7-0.8-0.5-0.6
Sr content in liver0.30.30.60.60.0-0.0-0.0-0.50.30.50.60.50.80.70.50.60.60.7-0.7
Zn content in liver0.00.10.2-0.0-0.00.00.0-0.40.10.40.30.0-0.00.10.30.20.1-0.2-0.5
Bone: minimum diameter1.01.82.5-1.51.4-1.4-1.61.11.61.61.41.41.51.40.91.41.31.0-0.3
Time in familiar zone, hab. session 10.20.20.60.6-0.40.40.4-0.80.00.30.40.50.60.30.40.30.20.2-0.3
Time in novel zone, hab. session 10.10.10.4-0.30.6-0.6-0.50.60.30.10.10.0-0.00.30.10.20.30.5-0.3
Total zone transitions, hab. session 11.21.74.3-1.92.0-2.0-2.02.11.40.90.70.70.70.80.80.91.01.10.0
Total locomotion distance, hab. session 11.42.03.1-1.31.8-1.8-1.81.71.61.21.11.21.11.31.21.41.51.7-0.5
Locomotion velocity, hab. session 11.31.83.8-1.61.9-1.9-1.81.91.51.00.90.90.81.11.01.21.21.4-0.1
Time in familiar zone, hab. session 21.61.73.11.8-1.61.61.7-1.4-1.6-1.5-1.2-0.8-0.8-1.2-1.1-1.1-1.2-0.80.2
Time in novel zone, hab. session 21.41.53.2-1.81.8-1.8-1.61.51.41.20.90.60.61.00.90.91.00.60.2
Total zone transitions, hab. session 23.24.05.5-1.42.1-2.1-2.21.42.42.22.12.01.92.12.22.12.22.1-1.4
Total locomotion distance, hab. session 22.22.83.9-1.21.7-1.7-1.81.32.01.71.71.61.61.81.81.81.91.9-1.2
Locomotion velocity, hab. session 22.83.85.1-1.11.8-1.8-1.91.22.32.12.12.02.02.12.22.22.22.3-1.4
Novel to familiar place preference ratio1.51.73.4-1.20.1-0.1-0.21.3-0.8-1.3-1.6-1.8-1.8-1.4-1.4-1.5-1.3-1.41.6
Novelty place preference2.02.14.1-1.30.1-0.1-0.21.4-0.9-1.5-1.7-2.0-2.0-1.6-1.6-1.7-1.4-1.51.8
Time in novel zone, NPP test1.92.13.9-1.60.4-0.4-0.41.7-0.7-1.3-1.7-1.9-2.0-1.5-1.5-1.6-1.3-1.51.8
Total zone transitions, NPP test1.92.74.70.30.8-0.8-0.9-0.21.61.92.02.22.21.92.12.01.92.1-1.4
Total locomotion distance, NPP test1.52.13.70.30.6-0.6-0.6-0.21.41.61.81.81.91.71.81.71.71.9-1.2
Locomotion velocity, NPP test1.31.83.60.70.4-0.4-0.3-0.41.21.41.61.81.81.61.71.61.61.9-1.1
Intraocular pressure0.30.41.00.8-0.60.61.0-0.5-0.7-0.8-0.6-0.4-0.5-0.7-0.6-0.6-0.6-0.40.1
Delta distance traveled before/after self-admin0.10.10.60.1-0.20.20.1-0.40.20.50.40.80.80.30.30.30.20.10.2
Delta ambulatory time before/after self-admin0.10.10.7-0.1-0.00.0-0.1-0.20.20.50.40.80.70.30.30.30.30.10.3
Parametrial fat weight0.61.42.1-0.61.3-1.3-1.20.61.31.31.21.31.41.31.31.21.21.1-0.1
Pavlov. Cond. lever latency1.11.32.5-0.1-0.10.10.40.3-1.2-1.5-1.5-1.6-1.6-1.4-1.6-1.4-1.3-1.20.9
Pavlov. Cond. magazine entry latency1.41.93.3-1.01.2-1.2-1.30.61.61.81.61.51.51.41.61.51.51.1-0.3
Pavlov. Cond. change in total contacts0.80.81.6-0.10.4-0.4-0.4-0.10.91.11.11.01.11.01.31.11.00.9-1.0
Pavlov. Cond. index score2.43.05.1-0.51.0-1.0-1.10.11.92.32.22.12.22.02.22.12.01.7-1.2
Pavlov. Cond. latency score2.12.74.6-0.30.7-0.7-0.9-0.11.82.12.12.12.11.92.12.01.91.6-1.2
Pavlov. Cond. lever contacts1.41.73.1-0.00.3-0.3-0.6-0.21.41.71.71.71.71.51.71.61.51.3-1.1
Pavlov. Cond. magazine entry number1.92.34.51.3-1.41.41.5-0.7-1.9-2.1-1.8-1.5-1.6-1.6-1.8-1.7-1.6-1.10.4
Pavlov. Cond. intertrial magazine entries0.50.61.10.7-1.01.01.0-0.5-1.0-1.0-0.8-0.7-0.7-0.7-0.6-0.8-0.8-0.7-0.4
Pavlov. Cond. lever-magazine prob. diff.2.12.64.4-0.51.0-1.0-1.10.11.82.12.02.02.01.82.11.91.81.5-1.1
Pavlov. Cond. response bias1.72.14.1-0.91.1-1.1-1.20.41.72.01.81.61.61.61.91.71.61.1-0.7
Pavlov. Cond. lever latency2.73.76.32.3-2.42.42.5-2.1-2.3-1.9-1.7-1.3-1.4-1.7-1.9-1.7-1.8-1.51.3
Pavlov. Cond. magazine entry latency0.50.62.9-1.70.8-0.8-1.01.30.30.1-0.3-0.7-0.6-0.4-0.3-0.5-0.3-0.80.5
Pavlov. Cond. change in total contacts3.04.87.8-2.42.7-2.7-2.82.32.62.21.91.51.72.02.32.02.11.9-1.5
Pavlov. Cond. index score2.83.87.3-2.72.6-2.6-2.72.32.32.01.51.11.21.51.71.51.71.2-0.9
Pavlov. Cond. latency score2.33.06.0-2.42.3-2.3-2.42.12.11.81.41.01.11.41.61.31.51.0-0.8
Pavlov. Cond. lever contacts2.94.06.2-2.22.4-2.4-2.52.02.42.11.91.51.51.82.01.91.91.6-1.4
Pavlov. Cond. magazine entry number1.51.97.22.7-2.02.02.2-2.2-1.4-1.1-0.6-0.1-0.2-0.6-0.7-0.5-0.7-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.20.30.80.30.2-0.2-0.1-0.20.50.50.70.90.80.70.50.70.70.9-0.1
Pavlov. Cond. lever-magazine prob. diff.2.53.46.3-2.52.4-2.4-2.52.12.21.91.51.11.31.51.71.51.61.1-0.9
Pavlov. Cond. response bias2.53.56.9-2.52.4-2.4-2.62.32.21.81.41.01.11.51.61.41.61.2-1.3
Time in closed arm before self-admin0.70.91.40.7-0.50.51.2-0.7-1.2-1.1-1.1-0.8-0.5-1.2-1.0-1.0-1.2-1.11.0
Time in closed arm after self-admin0.20.20.70.5-0.50.50.7-0.6-0.5-0.4-0.4-0.8-0.6-0.4-0.3-0.3-0.4-0.4-0.4
Time in open arm before self-admin2.83.15.3-2.32.2-2.2-2.21.92.11.81.60.90.71.71.71.61.61.2-1.1
Time in open arm after self-admin0.20.21.1-0.90.4-0.4-0.81.00.3-0.0-0.2-0.0-0.4-0.1-0.2-0.20.00.00.4
Bone: periosteal estimation1.22.54.0-1.31.6-1.6-1.60.81.82.01.81.61.81.71.41.81.71.2-0.7
Bone: periosteal perimeter0.61.01.8-0.30.8-0.8-0.90.21.11.21.21.21.31.20.91.31.21.2-0.5
Bone: post-yield work0.20.30.70.3-0.20.20.2-0.80.40.90.80.70.70.70.80.70.50.2-0.3
Progressive ratio test 1 active lever presses3.54.39.21.2-0.80.8-0.0-1.41.52.22.63.03.02.42.12.22.22.2-2.7
Progressive ratio test 1 breakpoint3.94.810.41.2-0.80.8-0.1-1.41.62.42.73.23.22.52.32.42.32.4-2.7
Progressive ratio test 1 inactive lever presses1.11.64.81.6-1.01.00.8-1.50.30.81.21.61.61.01.01.00.91.1-2.2
Progressive ratio test 2 active lever presses3.94.611.32.1-1.41.40.7-2.31.12.02.52.82.72.32.12.02.02.1-3.4
Progressive ratio test 2 breakpoint3.84.410.52.0-1.31.30.7-2.31.11.92.42.82.72.22.12.01.92.0-3.2
Progressive ratio test 2 inactive lever presses0.71.12.91.7-1.61.61.1-1.6-0.20.20.51.41.40.40.30.30.30.6-1.2
Incentive Sensitization - Responses1.01.44.21.7-1.21.21.1-2.00.10.81.11.41.50.90.90.80.60.7-1.6
Incentive Sensitization - Breakpoint1.11.44.01.7-1.21.21.1-2.00.10.81.11.41.40.90.90.80.60.8-1.7
Sum of active levers in priming session hrs 5-60.50.40.90.60.2-0.20.0-0.40.50.50.80.90.80.80.80.80.71.0-0.6
Progressive ratio0.10.20.90.4-0.30.30.3-0.4-0.00.20.20.90.80.10.10.20.10.1-0.2
Food seeking constrained by brief footshock1.51.95.5-2.22.0-2.0-2.22.31.50.90.60.00.30.80.70.71.00.7-0.6
Seeking ratio, punishment vs. effort0.50.72.5-1.51.3-1.3-1.31.60.60.2-0.1-1.0-0.70.10.10.00.30.1-0.1
Retroperitoneal fat weight2.19.013.4-2.83.4-3.4-3.72.63.53.22.92.82.83.03.03.03.12.8-1.1
Reaction time number correct0.81.63.31.7-0.50.50.5-1.50.50.91.41.81.71.31.31.21.21.5-1.6
Reaction time mean minus median0.92.27.6-2.82.3-2.3-1.72.60.5-0.2-0.6-1.1-1.2-0.5-0.4-0.3-0.4-0.71.7
Reaction time mean minus median AUC0.51.44.8-2.21.9-1.9-1.42.00.5-0.1-0.4-0.8-0.9-0.3-0.3-0.1-0.2-0.51.2
Reaction time num false alarms0.10.10.6-0.10.2-0.20.10.3-0.1-0.4-0.3-0.2-0.1-0.4-0.3-0.2-0.2-0.10.7
Reaction time num false alarms AUC0.00.00.20.30.0-0.00.4-0.2-0.1-0.2-0.00.10.1-0.2-0.00.1-0.10.10.4
Reaction time trials correct on left0.81.63.31.7-0.50.50.5-1.50.50.91.41.81.71.31.31.21.21.5-1.6
Reaction time trials on left0.81.53.01.6-0.40.40.5-1.50.50.91.31.71.61.21.21.21.11.5-1.5
Reaction time mean1.11.85.0-2.21.6-1.6-1.42.20.1-0.7-1.0-1.6-1.7-0.8-0.9-0.8-0.6-0.81.2
Reaction time mean AUC1.22.05.0-2.21.4-1.4-1.32.2-0.1-0.9-1.3-1.9-1.9-1.1-1.2-1.0-0.8-1.01.3
Median of all reaction times1.01.43.3-1.50.8-0.8-0.81.6-0.4-1.0-1.3-1.8-1.8-1.1-1.2-1.1-0.9-0.90.9
Reaction time omissions2.23.15.7-2.01.1-1.1-0.82.2-0.8-1.6-2.0-2.3-2.4-1.8-1.8-1.8-1.6-1.72.2
Reaction time false alarm rate0.20.20.7-0.60.5-0.5-0.10.7-0.1-0.3-0.4-0.5-0.5-0.5-0.4-0.2-0.3-0.30.9
Reaction time premature initiation rate4.25.88.32.0-2.92.92.6-1.8-2.8-2.5-2.5-2.1-2.2-2.6-2.6-2.6-2.5-2.20.8
Reaction time premature initiations1.83.37.02.6-2.62.62.5-2.3-2.1-1.6-1.3-0.9-1.0-1.5-1.5-1.5-1.5-1.0-0.2
Std. dev. reaction times1.42.69.2-3.02.6-2.6-2.12.90.8-0.0-0.5-1.2-1.3-0.4-0.4-0.2-0.2-0.51.6
Reaction time trials completed0.81.53.01.6-0.40.40.5-1.50.50.91.31.71.61.21.21.21.11.5-1.5
Reaction time trials AUC0.81.53.11.6-0.40.40.4-1.40.50.91.31.81.61.21.31.21.11.5-1.6
Run reversals in cocaine runway, females0.50.51.5-0.10.6-0.6-0.40.20.70.80.81.11.20.70.70.90.80.8-0.3
Run reversals in cocaine runway, males1.01.01.3-0.60.9-0.9-0.80.41.11.11.11.01.01.11.11.11.10.9-0.9
Latency to leave start box in cocaine runway0.91.02.0-0.8-0.40.4-0.30.8-0.8-1.0-1.4-1.2-0.8-1.3-1.2-1.4-1.1-1.30.6
Latency to leave start box in cocaine runway, F1.31.53.0-0.2-1.11.10.20.0-1.3-1.2-1.6-1.4-0.9-1.5-1.6-1.7-1.4-1.70.9
Latency to leave start box in cocaine runway, M0.50.52.4-1.30.8-0.8-0.81.50.1-0.4-0.6-0.6-0.5-0.5-0.2-0.4-0.4-0.40.4
Std. dev. time between licks in bursts0.30.41.4-1.21.0-1.0-1.01.10.60.40.2-0.3-0.30.10.40.20.30.1-0.2
Total sessions with >9 infusions1.51.83.71.9-1.31.31.0-1.90.30.91.31.81.71.11.01.00.91.1-1.8
Short access day 1 total inactive lever presses0.50.61.81.2-1.01.00.7-1.3-0.10.40.51.11.30.40.40.30.30.4-0.7
Short access day 10 total inactive lever presses0.10.30.7-0.80.7-0.7-0.70.70.0-0.2-0.3-0.8-0.7-0.3-0.2-0.2-0.2-0.40.7
Short access day 1 total infusions1.21.53.31.7-1.31.30.9-1.70.20.81.11.61.80.90.90.80.81.0-1.7
Short access day 10 total infusions1.82.35.41.6-0.80.80.6-1.60.81.31.72.02.11.61.51.51.41.6-2.3
Short access total infusions2.32.96.42.2-1.51.51.1-2.20.51.21.72.02.11.51.41.41.31.6-2.5
Short access day 1 locomotion0.50.72.0-0.20.1-0.1-0.4-0.20.81.21.11.21.40.90.90.90.90.5-0.8
Short access day 10 total locomotion0.10.30.7-0.10.1-0.1-0.1-0.30.50.80.80.50.70.80.60.80.50.3-0.1
Short access total locomotion1.51.83.50.50.0-0.0-0.1-1.01.11.61.81.71.91.61.61.71.31.1-1.7
One hour access (0.3 mA shock)2.42.85.41.2-1.21.20.1-1.61.11.92.12.01.82.01.71.71.71.7-2.3
Compulsive drug intake2.32.84.7-1.91.9-1.9-2.21.52.01.91.71.00.71.71.81.71.71.3-0.9
One hour access (shock baseline)1.32.06.32.5-2.22.21.6-2.5-0.50.20.71.31.40.50.30.30.30.6-1.1
Social response proportion3.33.75.82.0-2.02.02.4-1.9-2.4-2.2-1.9-1.2-1.5-2.1-1.8-1.9-2.1-1.81.2
Social responses0.10.10.40.5-0.30.30.4-0.7-0.2-0.10.00.20.0-0.00.20.0-0.1-0.0-0.1
Social time4.25.78.62.0-2.02.02.4-1.5-2.8-2.9-2.7-2.9-2.8-2.6-2.5-2.6-2.6-2.20.8
Soleus weight0.92.712.0-2.61.2-1.2-1.12.4-0.1-0.7-1.2-1.5-1.8-1.1-1.1-1.0-1.0-1.43.5
Bone: stiffness1.01.62.3-0.61.3-1.3-1.10.51.51.51.51.11.11.51.41.51.51.4-1.1
Tibialis anterior weight5.017.127.3-4.65.2-5.2-5.14.14.94.43.83.33.33.94.04.04.03.4-0.3
Time to tail flick, vehicle, before self-admin1.01.12.00.3-0.30.30.7-0.0-1.2-1.4-1.4-1.2-1.3-1.4-1.3-1.3-1.2-1.10.2
Time to tail flick, vehicle, after self-admin0.91.24.52.1-1.21.21.9-2.1-1.2-0.8-0.4-0.0-0.2-0.5-0.4-0.4-0.8-0.5-0.9
Time to tail flick, test, before self-admin1.11.12.6-1.60.7-0.7-0.71.4-0.3-0.6-1.0-1.1-1.5-1.0-1.0-0.9-0.8-1.11.4
Time to tail flick, test, after self-admin0.70.73.9-0.90.5-0.5-0.50.9-0.3-0.5-0.8-0.9-0.9-0.7-0.7-0.7-0.6-0.62.0
Delta time to tail flick, vehicle, before/after SA1.21.14.82.1-1.51.51.7-2.2-0.9-0.40.00.10.2-0.1-0.1-0.0-0.4-0.1-0.4
Delta time to tail flick, test, before/after SA0.10.10.20.30.1-0.1-0.1-0.20.20.20.40.20.30.40.40.40.30.50.2
Tibia length0.92.611.03.0-1.91.91.9-3.3-0.40.71.11.31.20.80.90.80.60.5-1.8
Ambulatory time before self-admin0.81.22.1-0.91.4-1.4-1.10.61.31.21.20.40.31.21.31.31.10.9-1.4
Ambulatory time after self-admin1.21.42.2-0.61.2-1.2-0.80.21.31.51.41.21.11.41.51.51.21.0-1.1
Bone: tissue strength1.41.43.2-0.3-0.10.10.30.8-1.1-1.6-1.6-1.7-1.8-1.4-1.4-1.4-1.3-1.00.9
Total heroin consumption0.30.31.0-0.80.9-0.9-0.60.70.40.30.10.80.50.10.20.20.20.11.0
Bone: trabecular number0.20.31.1-0.80.6-0.6-0.61.00.1-0.2-0.3-0.4-0.4-0.2-0.1-0.2-0.1-0.11.0
Bone: trabecular spacing0.50.72.51.3-1.31.31.1-1.6-0.40.10.40.40.40.20.10.2-0.0-0.0-1.2
Bone: trabecular thickness0.50.61.40.3-0.80.80.8-0.7-0.8-0.5-0.7-1.0-1.0-0.8-0.5-0.9-0.8-1.20.7
Bone: trabecular tissue density1.92.83.71.4-1.91.91.9-1.4-1.9-1.7-1.6-1.8-1.7-1.8-1.6-1.7-1.8-1.80.8
Water consumed over 24 hours0.20.30.9-0.90.5-0.5-0.70.50.70.80.60.60.50.40.50.50.40.00.5
Number of responses in last shaping day0.40.52.60.10.1-0.1-0.2-0.20.50.70.71.41.60.70.60.60.60.50.4