Hub : Genes

Bbs7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Bbs7 0.08 0.05 2.8e-11 0.03 0.06 0.06 0.05 1.5e-05 4.9e-10 3.9e-09 1.2e-08
2 Liver mRNA stability Bbs7 0.09 0.05 3.2e-08 0.06 0.05 0.05 0.05 4.6e-07 1.5e-06 4.3e-06 4.1e-06
3 PL gene expression Bbs7 0.12 0.08 6.2e-08 0.07 0.06 0.06 0.06 4.8e-08 1.6e-07 1.8e-07 1.4e-07
4 Brain gene expression Bbs7 0.2 0.11 5.2e-08 0.09 0.07 0.09 0.08 1.8e-08 1.6e-07 2.1e-08 9.0e-08
5 Liver gene expression Bbs7 0.33 0.13 0.0e+00 0.18 0.22 0.19 0.21 2.1e-19 1.4e-23 3.8e-21 2.8e-23
6 pVTA gene expression Bbs7 0.16 0.08 3.1e-11 0.07 0.13 0.13 0.13 3.6e-06 1.4e-10 2.5e-10 1.9e-10
7 LHb mRNA stability Bbs7 0.34 0.15 2.6e-05 0.13 0.19 0.12 0.16 6.3e-04 2.9e-05 8.8e-04 1.4e-04
8 Brain mRNA stability Bbs7 0.26 0.11 0.0e+00 0.27 0.28 0.28 0.28 5.5e-25 4.4e-26 4.4e-26 8.6e-26
9 IC mRNA stability Bbs7 0.08 0.07 8.8e-03 0.07 0.04 0.02 0.06 7.5e-04 9.5e-03 6.1e-02 1.9e-03
10 IL mRNA stability Bbs7 0.19 0.13 3.5e-03 0.15 0.11 0.13 0.14 2.3e-04 1.5e-03 4.7e-04 2.5e-04
11 BLA mRNA stability Bbs7 0.29 0.18 5.0e-08 0.14 0.14 0.1 0.15 8.5e-08 4.7e-08 3.9e-06 3.1e-08
12 OFC mRNA stability Bbs7 0.33 0.14 9.3e-06 0.2 0.21 0.14 0.22 2.0e-05 1.0e-05 2.9e-04 5.0e-06
13 pVTA mRNA stability Bbs7 0.12 0.07 3.7e-08 0.1 0.1 0.1 0.1 1.9e-08 3.6e-08 9.5e-09 2.3e-08
14 NAcc mRNA stability Bbs7 0.09 0.06 4.9e-10 0.06 0.06 0.06 0.06 1.1e-09 7.6e-10 2.9e-09 3.9e-09
15 PL mRNA stability Bbs7 0.3 0.13 0.0e+00 0.19 0.2 0.19 0.19 1.8e-20 1.6e-21 2.2e-20 2.4e-20
16 IL gene expression Bbs7 0.31 0.16 2.6e-04 0.06 0.11 0.13 0.09 1.5e-02 1.2e-03 5.7e-04 3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.20.30.9-0.4-0.00.0-0.00.3-0.4-0.50.60.80.8-0.7-0.60.6-0.6-0.9-0.9
Area under the delay curve0.50.82.4-1.5-1.31.31.01.50.2-0.20.50.90.9-0.4-0.40.4-0.3-0.5-1.1
BMI with tail2.910.218.1-3.7-4.14.14.33.43.73.2-2.8-2.5-2.53.02.7-2.93.02.50.5
BMI without tail0.73.68.4-2.8-2.82.82.92.52.11.7-1.3-0.9-0.91.41.3-1.51.51.2-0.4
Body weight2.812.222.4-4.1-4.14.14.73.64.33.9-3.3-2.4-2.23.43.1-3.33.62.81.5
Weight adjusted by age0.00.10.30.40.2-0.2-0.2-0.3-0.3-0.30.20.10.3-0.1-0.10.1-0.20.0-0.5
Bone surface0.51.01.8-0.6-1.31.31.10.51.11.1-1.0-0.8-0.91.11.1-1.11.00.90.5
Bone volume0.00.00.1-0.2-0.40.40.2-0.10.20.3-0.20.10.00.20.3-0.20.1-0.20.1
Breakpoint value in progressive ratio session0.81.42.2-1.1-1.41.41.51.21.41.2-1.1-1.2-1.01.11.1-1.11.21.10.2
Number of licking bursts0.72.03.6-1.7-1.71.71.91.31.81.7-1.3-0.9-0.91.31.5-1.31.40.90.6
Context. condit. distance diff. score2.12.64.7-0.11.0-1.0-1.1-0.2-1.6-1.61.82.02.0-1.8-1.81.8-1.9-2.2-1.9
Locomotion velocity, session 12.02.34.00.3-0.70.70.7-0.41.51.7-1.9-2.0-2.01.81.9-1.81.81.81.5
Locomotion distance, session 13.14.05.9-0.5-1.61.61.60.52.12.3-2.3-2.4-2.42.32.3-2.32.32.31.7
Locomotion velocity, session 22.32.85.40.3-0.50.50.6-0.61.62.0-2.1-2.3-2.31.92.1-2.01.91.81.6
Locomotion distance, session 21.82.54.30.2-0.90.90.7-0.51.51.9-2.0-2.1-2.11.82.0-1.91.81.71.6
Locomotion velocity, session 30.00.00.10.20.0-0.00.1-0.10.20.2-0.2-0.3-0.30.20.0-0.20.30.30.3
Locomotion distance, session 30.10.10.70.30.1-0.1-0.1-0.50.20.4-0.4-0.3-0.30.30.4-0.30.30.20.8
Stereotopy head waving bouts, day 30.91.02.50.8-0.10.10.0-0.80.71.0-1.2-1.2-1.31.21.0-1.21.11.21.6
Stereotopy head waving duration, day 30.10.10.3-0.2-0.50.50.50.40.40.2-0.3-0.3-0.30.40.1-0.40.40.50.5
Locomotion velocity, session 71.01.11.90.3-0.30.30.3-0.41.01.2-1.3-1.3-1.31.21.2-1.21.21.21.4
Locomotion distance, session 70.91.22.71.41.6-1.6-1.6-1.6-1.2-0.70.60.50.5-0.8-0.70.8-0.9-1.0-0.3
Stereotopy head waving bouts, day 70.91.01.6-0.3-0.90.90.80.11.11.3-1.2-1.0-1.11.11.0-1.11.10.91.3
Stereotopy head waving duration, day 70.80.91.7-0.4-0.90.90.90.31.11.1-1.1-0.9-1.01.01.0-1.01.10.91.3
Locomotion velocity, session 80.30.31.4-1.2-0.80.80.81.00.30.10.20.20.1-0.1-0.10.1-0.1-0.3-0.8
Locomotion distance, session 80.10.10.3-0.5-0.40.40.30.10.30.4-0.2-0.10.00.10.2-0.20.1-0.3-0.3
Degree of sensitization distance1.71.83.11.31.8-1.8-1.8-1.4-1.5-1.21.10.90.9-1.3-1.21.2-1.4-1.3-1.0
Degree of sensitization stereotypy0.50.61.1-0.8-1.11.11.00.70.90.8-0.6-0.4-0.50.60.5-0.60.70.50.7
Conditioned locomotion2.02.43.21.41.7-1.7-1.7-1.3-1.8-1.71.51.41.5-1.5-1.61.5-1.6-1.5-1.3
Cocaine response after cond. corrected1.42.13.6-0.00.8-0.8-0.90.0-1.5-1.71.71.81.8-1.7-1.91.7-1.7-1.8-1.1
Cocaine response after cond. not corrected0.40.61.40.30.6-0.6-0.6-0.1-0.9-1.00.91.00.9-0.9-1.20.9-0.9-0.80.1
Cocaine response before conditioning2.32.85.80.1-1.01.01.00.21.61.6-1.9-1.9-2.01.91.8-1.92.02.32.4
Saline control response2.02.74.5-0.5-1.11.11.40.61.91.8-1.9-1.8-1.62.11.9-1.92.02.11.5
Bone: connectivity density0.91.52.7-1.2-1.61.61.51.11.41.3-1.1-0.9-0.91.11.2-1.21.21.0-0.1
Bone: cortical apparent density0.50.82.91.41.4-1.4-1.5-1.7-0.8-0.30.2-0.00.1-0.40.00.4-0.5-0.60.2
Bone: cortical area0.50.81.4-0.9-1.21.21.10.71.01.0-0.9-0.7-0.80.90.7-0.90.90.70.5
Bone: cortical porosity0.91.03.7-1.2-1.11.10.91.9-0.1-1.01.00.80.8-0.8-0.90.6-0.5-0.1-1.4
Bone: cortical porosity0.91.04.0-1.3-1.21.21.12.00.0-0.90.90.80.7-0.6-0.80.5-0.30.1-1.3
Bone: cortical thickness0.10.10.3-0.3-0.50.50.20.5-0.1-0.40.40.50.4-0.3-0.30.3-0.2-0.10.1
Bone: cortical thickness0.50.61.8-0.6-0.90.90.80.50.80.7-0.7-0.4-0.50.70.9-0.60.70.51.3
Bone: cortical tissue density0.50.83.01.41.4-1.4-1.4-1.7-0.8-0.20.1-0.10.1-0.30.10.4-0.5-0.50.3
Condit. Reinf. active minus inactive responses0.60.71.1-0.8-0.70.70.70.71.01.0-0.9-0.8-0.90.91.1-0.90.90.80.8
Condit. Reinf. active-inactive response ratio0.20.21.3-1.1-0.70.70.61.10.40.10.10.30.10.00.10.10.0-0.10.0
Condit. Reinf. active responses3.03.95.5-1.6-2.02.01.91.52.42.2-2.1-1.8-1.92.12.3-2.12.12.01.5
Condit. Reinf. inactive responses5.47.19.9-1.2-2.42.42.41.23.02.9-2.9-2.8-2.82.93.2-3.03.03.12.0
Incentive salience index mean0.70.91.4-0.7-0.70.70.80.61.11.1-1.1-0.9-1.01.11.2-1.01.00.91.0
Condit. Reinf. lever presses1.31.92.8-0.3-0.80.80.90.31.51.6-1.7-1.6-1.71.61.7-1.61.61.61.4
Condit. Reinf. active minus inactive responses1.11.73.8-0.8-1.41.41.20.91.41.2-1.2-1.3-1.31.21.2-1.21.31.42.0
Condit. Reinf. active-inactive response ratio0.30.40.8-0.10.2-0.2-0.30.1-0.6-0.80.80.80.8-0.9-0.80.8-0.7-0.70.0
Condit. Reinf. active responses4.15.99.3-1.1-2.32.32.11.22.62.5-2.6-2.6-2.62.62.6-2.62.72.73.1
Condit. Reinf. inactive responses8.212.115.3-1.7-3.23.23.21.73.93.8-3.8-3.6-3.73.93.9-3.83.93.83.5
Condit. Reinf. lever presses0.81.22.7-1.6-1.51.51.51.51.31.0-0.8-0.7-0.70.70.8-0.80.80.60.8
Condit. Reinf. lever reinforcers received3.75.28.2-1.1-2.12.12.01.12.52.4-2.4-2.4-2.42.42.5-2.42.52.52.9
Conditioned reinforcement - actives0.31.13.01.61.4-1.4-1.0-1.7-0.10.5-0.8-1.2-1.70.60.5-0.60.50.60.9
Conditioned reinforcement - inactives0.30.82.41.11.5-1.5-1.2-1.0-1.0-0.70.70.30.0-0.8-0.70.8-0.7-0.60.3
Conditioned locomotion1.01.54.00.80.7-0.7-0.5-1.40.71.4-1.5-1.7-2.01.41.3-1.31.00.91.1
Patch foraging indifference point 0 sec0.51.45.5-2.3-1.51.51.92.11.30.9-0.5-0.40.00.70.4-0.50.70.3-0.6
Patch foraging indifference point AUC0.30.61.20.2-0.30.30.2-0.20.80.9-1.0-0.9-0.81.01.1-1.10.91.00.8
Delay disc. indifference point, 0s delay0.40.41.11.00.2-0.2-0.6-1.00.20.5-0.7-0.9-0.70.70.7-0.70.50.70.2
Delay disc. indifference point, 16s delay0.40.52.3-1.2-1.51.50.81.00.50.2-0.00.30.60.10.1-0.20.1-0.1-0.2
Delay disc. indifference point, 2s delay0.40.51.7-1.3-1.01.01.01.30.40.10.20.70.6-0.0-0.10.20.0-0.2-0.7
Delay disc. indifference point, 24s delay0.50.82.2-0.2-0.10.1-0.40.1-0.8-0.91.01.11.2-1.1-0.90.9-1.0-1.0-1.5
Delay disc. indifference point, 4s delay0.90.92.7-1.6-1.61.61.51.71.00.6-0.3-0.10.00.50.4-0.50.60.5-0.2
Delay disc. indifference point, 8s delay0.61.02.3-0.6-0.00.00.00.6-0.7-1.01.21.51.4-1.1-1.11.2-1.0-1.1-1.3
Indifference point function ln k0.51.72.9-0.80.3-0.3-0.10.9-1.0-1.31.61.51.4-1.6-1.71.6-1.4-1.5-1.7
Indifference point function log k0.51.72.9-0.80.3-0.3-0.10.9-1.0-1.31.61.51.4-1.6-1.71.6-1.4-1.5-1.7
Patch foraging total patch changes 0 sec0.41.34.6-2.2-1.41.41.82.11.20.8-0.5-0.4-0.10.70.5-0.50.70.5-0.6
Patch foraging total patch changes 12 sec0.10.10.40.20.5-0.5-0.4-0.2-0.1-0.1-0.00.30.60.00.0-0.0-0.1-0.00.1
Patch foraging total patch changes 18 sec0.30.71.1-0.9-0.60.60.90.81.00.9-0.8-1.0-0.70.90.8-0.80.80.70.4
Patch foraging total patch changes 24 sec0.72.34.1-2.0-1.81.82.01.81.81.6-1.3-0.9-0.71.41.3-1.31.51.11.2
Patch foraging total patch changes 6 sec0.61.02.7-1.6-1.21.21.41.61.20.8-0.7-0.2-0.10.90.6-0.80.90.8-0.2
Patch foraging time to switch 0 sec0.21.01.71.11.1-1.1-1.3-1.2-1.2-0.90.80.70.7-0.9-0.90.8-1.0-1.0-0.0
Patch foraging water rate 0 sec0.00.10.5-0.6-0.40.40.60.70.3-0.0-0.00.30.30.10.0-0.00.10.20.0
Patch foraging water rate 12 sec0.10.40.8-0.0-0.20.20.60.20.70.7-0.7-0.6-0.80.80.7-0.60.80.90.8
Patch foraging water rate 18 sec0.30.81.6-0.5-0.60.60.90.41.01.0-1.0-0.7-1.00.90.9-0.91.00.91.3
Patch foraging water rate 24 sec0.60.81.3-0.3-0.70.70.90.21.11.1-1.1-0.8-0.71.11.1-1.01.11.00.4
Patch foraging water rate 6 sec0.10.10.3-0.1-0.10.10.50.20.40.3-0.3-0.3-0.40.30.3-0.20.40.60.5
Seeking ratio, delayed vs. immediate footshock1.21.73.7-1.9-1.81.81.91.81.31.0-0.7-0.9-0.90.90.7-0.80.90.7-1.0
Distance traveled before self-admin0.61.43.2-1.4-1.81.81.41.11.31.1-1.0-0.2-0.11.11.1-1.21.00.80.9
Distance traveled after self-admin1.72.94.2-1.6-2.12.11.71.12.02.0-1.8-1.5-1.41.81.9-1.91.71.40.9
Extensor digitorum longus weight2.610.420.6-4.4-4.54.54.44.23.83.0-2.3-2.1-1.92.62.6-2.62.82.2-0.5
Bone: elastic displacement3.64.57.6-0.70.7-0.7-0.70.9-2.0-2.52.82.42.4-2.7-2.62.6-2.5-2.5-2.6
Bone: elastic work3.44.46.90.41.3-1.3-1.5-0.2-2.3-2.62.62.52.4-2.6-2.62.5-2.5-2.3-1.6
Bone: endosteal estimation1.33.15.3-1.3-1.51.51.70.72.12.3-2.1-2.0-2.12.01.7-2.11.91.40.8
Bone: endosteal perimeter0.92.24.5-0.4-0.80.81.00.01.61.9-1.9-2.0-2.11.81.6-1.91.71.50.5
Epididymis fat weight0.94.79.8-3.0-2.82.83.12.92.62.1-1.7-1.2-1.21.81.6-1.72.01.50.7
Delta time in closed arm before/after self-admin0.40.30.6-0.7-0.50.50.80.70.80.6-0.6-0.1-0.00.70.6-0.60.70.60.5
Delta time in open arm before/after self-admin0.91.01.70.41.0-1.0-0.5-0.1-1.1-1.21.21.01.3-1.2-1.31.3-1.0-0.9-0.5
Diff in mean of infusions in LGA sessions0.20.31.2-1.1-0.80.80.60.90.20.00.20.20.4-0.2-0.10.1-0.2-0.4-0.2
Delay discount exponential model param0.70.92.41.61.3-1.3-0.9-1.5-0.10.4-0.7-1.1-1.00.50.6-0.50.40.61.2
Extinction: sum of active levers before priming0.30.51.20.40.2-0.20.0-0.50.50.7-0.9-1.0-0.60.80.8-0.70.70.71.1
Active lever presses in extinction session 60.10.10.2-0.5-0.30.30.40.50.0-0.10.20.30.2-0.2-0.20.2-0.1-0.30.0
Bone: final force2.03.35.8-1.8-2.42.42.21.82.11.7-1.6-1.2-1.21.81.6-1.81.81.71.2
Bone: final moment1.72.85.4-1.9-2.32.32.21.91.91.5-1.4-0.9-0.91.61.4-1.51.61.40.9
Food consumed during 24 hour testing period0.10.10.4-0.7-0.30.30.30.30.40.5-0.3-0.3-0.30.10.4-0.20.1-0.2-0.6
Glucose0.10.20.90.60.5-0.5-0.4-0.6-0.1-0.0-0.2-0.2-0.30.20.0-0.10.00.21.0
Heart weight1.62.67.0-2.5-2.22.22.52.61.91.2-0.9-0.6-0.81.11.0-1.01.31.10.2
Delay discount hyperbolic model param0.70.92.61.61.3-1.3-1.0-1.6-0.20.3-0.7-1.1-1.00.50.5-0.50.40.51.2
Intermittent access intake day 1-15 change0.31.63.01.71.7-1.7-1.7-1.5-1.5-1.21.10.10.1-1.1-1.11.1-1.2-0.9-0.8
Intermittent access intake escalation0.21.12.21.51.5-1.5-1.5-1.3-1.2-1.00.8-0.00.0-0.8-0.80.9-0.9-0.7-0.6
Intermittent access intake escalation 20.30.51.10.81.0-1.0-1.0-0.8-0.9-0.70.60.1-0.0-0.6-0.60.6-0.7-0.6-0.8
Intermitt. access day 1 inactive lever presses0.00.20.40.50.7-0.7-0.5-0.4-0.5-0.50.50.50.1-0.5-0.40.5-0.5-0.40.0
Intermitt. access day 15 inactive lever presses0.10.30.80.70.4-0.4-0.30.0-0.6-0.90.70.0-0.2-0.6-0.60.6-0.5-0.1-0.8
Intermitt. access escalation Index0.10.30.60.20.7-0.7-0.30.2-0.4-0.60.60.70.8-0.5-0.60.7-0.3-0.20.6
Intermittent access day 1 total infusions0.82.46.62.51.8-1.8-1.6-2.6-0.00.8-1.2-1.5-1.51.00.9-1.00.81.02.2
Intermittent access day 15 total infusions0.92.37.02.62.4-2.4-1.9-2.6-0.60.2-0.6-1.4-1.40.40.3-0.30.20.51.7
Intermittent access terminal intake (last 3 days)1.42.59.02.92.4-2.4-2.2-3.0-0.9-0.1-0.4-1.2-1.30.20.1-0.1-0.10.30.9
Intermittent access total infusions2.73.26.02.11.5-1.5-0.9-2.20.71.4-1.9-2.2-2.31.81.6-1.61.51.72.4
Intermittent access day 1 locomotion1.22.34.21.20.7-0.7-0.4-1.70.91.6-1.9-2.0-2.01.71.6-1.71.41.41.9
Intermittent access day 15 total locomotion0.31.33.70.51.0-1.0-0.2-1.10.61.4-1.3-1.9-1.91.20.9-1.00.90.70.9
Intermittent access total locomotion2.02.44.90.80.9-0.9-0.2-1.51.01.9-2.0-2.2-2.21.91.6-1.71.51.31.4
Intermittent access standard deviation0.00.20.50.30.5-0.5-0.20.1-0.5-0.70.70.40.3-0.5-0.70.7-0.5-0.3-0.5
Left kidney weight0.10.72.9-1.7-1.01.01.41.50.50.20.10.70.8-0.2-0.20.2-0.1-0.5-0.5
Right kidney weight0.42.910.4-3.2-2.62.62.83.21.40.7-0.20.50.40.20.2-0.30.60.1-0.7
Cocaine induced anxiety0.30.93.3-1.4-1.31.31.21.20.80.7-0.4-1.0-0.50.40.5-0.50.50.3-1.8
Post-drug Anxiety0.91.03.2-1.5-1.61.61.51.80.90.4-0.2-0.5-0.30.30.3-0.30.50.5-1.3
Baseline Anxiety0.30.51.60.50.3-0.3-0.40.0-0.6-0.90.71.30.9-0.7-0.70.6-0.5-0.41.0
Tail length0.00.20.5-0.7-0.50.50.70.60.30.2-0.00.50.70.00.0-0.10.2-0.00.1
Length with tail0.52.24.6-1.8-1.61.62.11.61.91.7-1.5-0.5-0.41.41.3-1.41.61.11.4
Length without tail1.15.810.1-2.8-2.62.63.22.42.92.7-2.4-1.5-1.32.42.2-2.32.51.92.0
Times rat made contact with spout0.20.20.70.40.6-0.6-0.5-0.8-0.10.3-0.2-0.5-0.4-0.00.2-0.1-0.1-0.3-0.4
Lifetime Intake2.43.06.22.11.5-1.5-0.9-2.20.61.3-1.8-2.1-2.21.71.5-1.51.41.62.5
Liver weight, left0.20.30.80.80.3-0.3-0.3-0.90.20.5-0.6-0.8-0.60.50.6-0.50.40.40.8
Liver weight, right0.20.30.60.40.7-0.7-0.4-0.3-0.6-0.60.60.60.3-0.6-0.70.7-0.6-0.5-0.8
Locomotor activity0.10.10.4-0.1-0.50.50.10.60.1-0.40.20.0-0.0-0.1-0.1-0.00.00.40.1
Locomotor testing distance1.84.56.7-1.9-2.62.62.52.32.41.8-1.8-1.9-2.12.11.9-2.12.12.31.1
Locomotor testing rearing0.10.20.9-0.5-0.70.70.71.00.4-0.1-0.0-0.1-0.20.20.1-0.20.30.60.3
Locomotion in novel chamber1.01.42.1-1.4-1.21.21.41.11.51.3-1.2-1.0-0.71.21.2-1.21.20.90.6
Locomotion in novel chamber post-restriction0.10.20.8-0.5-0.90.90.50.70.40.1-0.1-0.2-0.00.20.3-0.20.30.40.4
Fecal boli incidents, locomotor time 10.61.62.71.31.5-1.5-1.6-1.1-1.5-1.31.21.60.8-1.2-1.11.4-1.2-1.2-0.3
Change in fecal boli incidents, locomotor task1.81.93.1-0.9-1.31.31.40.71.61.6-1.6-1.8-1.11.61.5-1.61.51.40.7
Time >=10cm from walls, locomotor time 10.20.30.60.40.0-0.0-0.1-0.40.40.5-0.7-0.8-0.30.60.7-0.60.60.70.6
Bouts of movement, locomotor time 11.21.52.71.11.6-1.6-1.5-1.0-1.4-1.21.20.70.5-1.4-1.31.4-1.2-1.1-1.2
Total resting periods, locomotor time 12.52.94.41.32.1-2.1-1.9-1.2-2.0-1.71.81.31.2-1.9-1.82.0-1.7-1.6-1.3
Rest time, locomotor task time 11.01.72.81.31.7-1.7-1.6-1.4-1.6-1.31.10.50.8-1.3-1.31.1-1.4-1.3-0.6
Distance moved, locomotor task time 10.82.33.5-1.3-1.61.61.61.11.91.8-1.7-1.1-1.21.81.7-1.51.71.50.9
Vertical activity count, locomotor time 10.32.13.7-1.8-1.81.81.91.61.81.6-1.3-0.6-0.81.41.4-1.21.51.10.5
Time >=10cm from walls, locomotor time 20.10.20.80.90.6-0.6-0.9-0.9-0.4-0.20.1-0.30.0-0.2-0.00.1-0.2-0.1-0.1
Bouts of movement, locomotor time 20.92.94.51.41.7-1.7-1.8-1.1-2.1-2.02.01.10.9-2.1-2.01.9-2.0-1.7-1.0
Total resting periods, locomotor time 20.52.23.61.11.3-1.3-1.4-0.8-1.8-1.91.81.00.9-1.9-1.81.7-1.8-1.5-0.9
Rest time, locomotor task time 20.20.30.70.00.3-0.3-0.30.1-0.7-0.70.80.40.6-0.9-0.80.7-0.7-0.6-0.4
Distance moved, locomotor task time 21.21.72.8-0.5-1.11.10.90.41.51.5-1.6-1.3-1.31.71.6-1.51.51.40.8
Vertical activity count, locomotor time 21.02.44.4-0.2-0.90.90.8-0.01.71.9-2.1-1.6-1.62.12.0-2.01.91.71.2
Light reinforcement 10.00.20.60.80.6-0.6-0.4-0.3-0.4-0.50.30.40.5-0.1-0.10.3-0.10.30.7
Light reinforcement 20.10.30.90.90.9-0.9-0.6-0.8-0.6-0.30.20.20.3-0.4-0.20.3-0.3-0.2-0.1
Bone: marrow area1.33.15.4-1.4-1.61.61.80.82.12.3-2.1-2.0-2.01.91.7-2.11.91.40.7
Bone: maximum diameter0.71.42.3-0.7-1.11.11.00.31.31.5-1.4-1.4-1.51.31.2-1.51.21.00.7
Bone: maximum force0.51.12.1-0.9-1.51.51.20.81.21.1-1.0-0.7-0.71.11.0-1.11.00.90.7
Bone: maximum moment0.40.82.0-1.1-1.41.41.10.91.00.9-0.7-0.4-0.40.80.8-0.80.80.60.3
Mean time between licks in bursts0.00.10.70.20.3-0.3-0.3-0.3-0.2-0.10.20.40.4-0.2-0.00.3-0.2-0.40.8
Mean num. licks in bursts0.71.83.41.51.8-1.8-1.9-1.4-1.6-1.51.20.60.6-1.2-1.31.1-1.4-1.0-0.9
Cd content in liver0.50.52.11.41.1-1.1-1.1-1.4-0.6-0.30.1-0.3-0.4-0.10.00.1-0.2-0.0-0.1
Co content in liver0.50.61.3-1.1-1.11.11.11.00.80.6-0.4-0.4-0.50.40.6-0.50.50.4-0.6
Cu content in liver0.10.10.3-0.0-0.20.20.2-0.20.40.6-0.5-0.5-0.40.30.5-0.40.40.20.1
Fe content in liver0.30.30.60.30.4-0.4-0.4-0.2-0.6-0.70.70.80.7-0.6-0.60.7-0.6-0.50.2
K content in liver1.00.91.60.71.0-1.0-1.1-0.8-1.1-0.90.81.31.3-1.0-0.90.9-1.0-1.10.2
Mg content in liver0.80.92.00.10.8-0.8-0.8-0.3-1.0-0.91.01.41.4-1.1-1.01.1-1.1-1.3-0.1
Mn content in liver1.61.82.41.11.5-1.5-1.5-1.0-1.6-1.51.31.21.2-1.4-1.51.3-1.4-1.2-0.7
Na content in liver1.21.33.1-0.2-0.80.80.8-0.01.21.4-1.4-1.0-0.91.31.4-1.31.31.21.8
Rb content in liver0.50.62.5-1.3-0.90.90.91.60.2-0.40.50.90.9-0.3-0.30.4-0.2-0.10.3
Se content in liver1.21.44.02.01.8-1.8-1.8-2.0-1.3-0.90.50.30.3-0.7-0.80.7-0.8-0.50.5
Sr content in liver0.30.30.60.6-0.00.00.0-0.50.30.5-0.6-0.5-0.80.70.5-0.60.60.70.7
Zn content in liver0.00.10.3-0.00.0-0.0-0.0-0.40.10.4-0.3-0.00.00.10.3-0.20.1-0.20.5
Bone: minimum diameter0.91.82.5-1.5-1.41.41.61.11.61.6-1.4-1.4-1.51.40.9-1.41.31.00.4
Time in familiar zone, hab. session 10.20.20.60.60.4-0.4-0.4-0.80.00.3-0.4-0.5-0.60.30.4-0.30.20.20.3
Time in novel zone, hab. session 10.10.10.4-0.3-0.60.60.50.60.30.1-0.1-0.00.00.30.1-0.20.30.50.3
Total zone transitions, hab. session 11.21.74.3-1.9-2.02.02.02.11.40.9-0.7-0.7-0.70.80.8-0.91.01.10.0
Total locomotion distance, hab. session 11.42.03.1-1.3-1.81.81.81.71.61.2-1.1-1.2-1.11.31.2-1.41.51.70.5
Locomotion velocity, hab. session 11.31.83.8-1.6-1.91.91.81.91.51.0-0.9-0.9-0.81.11.0-1.21.21.40.1
Time in familiar zone, hab. session 21.51.73.11.81.6-1.6-1.7-1.4-1.6-1.51.20.80.8-1.2-1.11.1-1.2-0.8-0.2
Time in novel zone, hab. session 21.31.53.2-1.8-1.81.81.61.51.41.2-0.9-0.6-0.61.00.9-0.91.00.6-0.1
Total zone transitions, hab. session 23.24.05.5-1.4-2.12.12.21.42.42.2-2.1-2.0-1.92.12.2-2.12.22.11.4
Total locomotion distance, hab. session 22.22.83.9-1.2-1.71.71.81.32.01.7-1.7-1.6-1.61.81.8-1.81.91.91.2
Locomotion velocity, hab. session 22.83.85.1-1.1-1.81.81.91.22.32.1-2.1-2.0-2.02.12.2-2.22.22.31.4
Novel to familiar place preference ratio1.31.73.4-1.2-0.10.10.21.3-0.8-1.31.61.81.8-1.4-1.41.5-1.3-1.4-1.5
Novelty place preference1.62.14.1-1.3-0.10.10.21.4-0.9-1.51.72.02.0-1.6-1.61.7-1.4-1.5-1.8
Time in novel zone, NPP test1.72.03.9-1.6-0.40.40.41.7-0.7-1.31.71.92.0-1.5-1.51.6-1.3-1.5-1.8
Total zone transitions, NPP test1.82.74.70.3-0.80.80.9-0.21.61.9-2.0-2.2-2.21.92.1-2.01.92.11.4
Total locomotion distance, NPP test1.52.13.70.3-0.60.60.6-0.21.41.6-1.8-1.8-1.91.71.8-1.71.71.91.2
Locomotion velocity, NPP test1.31.83.60.7-0.40.40.3-0.41.21.4-1.6-1.8-1.81.61.7-1.61.61.91.1
Intraocular pressure0.20.41.00.80.6-0.6-1.0-0.5-0.7-0.80.60.40.5-0.7-0.60.6-0.6-0.4-0.1
Delta distance traveled before/after self-admin0.10.10.60.10.2-0.2-0.1-0.40.20.5-0.4-0.8-0.80.30.3-0.30.20.1-0.1
Delta ambulatory time before/after self-admin0.10.10.7-0.10.0-0.00.1-0.20.20.5-0.4-0.8-0.70.30.3-0.30.30.1-0.2
Parametrial fat weight0.61.42.1-0.6-1.31.31.20.61.31.3-1.2-1.3-1.41.31.3-1.21.21.10.1
Pavlov. Cond. lever latency1.11.32.5-0.10.1-0.1-0.40.3-1.2-1.51.51.61.6-1.4-1.61.4-1.3-1.2-0.9
Pavlov. Cond. magazine entry latency1.41.93.3-1.0-1.21.21.30.61.61.8-1.6-1.5-1.51.41.6-1.51.51.10.3
Pavlov. Cond. change in total contacts0.70.81.6-0.1-0.40.40.4-0.10.91.1-1.1-1.0-1.11.01.3-1.11.00.91.0
Pavlov. Cond. index score2.43.05.1-0.5-1.01.01.10.11.92.3-2.2-2.1-2.22.02.2-2.12.01.71.2
Pavlov. Cond. latency score2.12.74.6-0.3-0.70.70.9-0.11.82.1-2.1-2.1-2.11.92.1-2.01.91.61.2
Pavlov. Cond. lever contacts1.41.73.1-0.0-0.30.30.6-0.21.41.7-1.7-1.7-1.71.51.7-1.61.51.31.1
Pavlov. Cond. magazine entry number1.82.34.51.31.4-1.4-1.5-0.7-1.9-2.11.81.51.6-1.6-1.81.7-1.6-1.1-0.5
Pavlov. Cond. intertrial magazine entries0.50.61.10.71.0-1.0-1.0-0.5-1.0-1.00.80.70.7-0.7-0.60.8-0.8-0.70.4
Pavlov. Cond. lever-magazine prob. diff.2.12.64.4-0.5-1.01.01.10.11.82.1-2.0-2.0-2.01.82.1-1.91.81.51.1
Pavlov. Cond. response bias1.72.14.1-0.9-1.11.11.20.41.72.0-1.8-1.6-1.61.61.9-1.71.61.10.7
Pavlov. Cond. lever latency2.63.76.32.32.4-2.4-2.5-2.1-2.3-1.91.71.31.4-1.7-1.91.7-1.8-1.5-1.4
Pavlov. Cond. magazine entry latency0.40.62.9-1.7-0.80.81.01.30.30.10.30.70.6-0.4-0.30.5-0.3-0.8-0.5
Pavlov. Cond. change in total contacts2.04.87.8-2.4-2.72.72.82.32.62.2-1.9-1.5-1.72.02.3-2.02.11.91.5
Pavlov. Cond. index score2.43.87.3-2.7-2.62.62.72.32.32.0-1.5-1.1-1.21.51.7-1.51.71.21.0
Pavlov. Cond. latency score1.93.06.0-2.4-2.32.32.42.12.11.8-1.4-1.0-1.11.41.6-1.31.51.00.9
Pavlov. Cond. lever contacts2.74.06.2-2.2-2.42.42.52.02.42.1-1.9-1.5-1.51.82.0-1.91.91.61.5
Pavlov. Cond. magazine entry number1.41.97.22.72.0-2.0-2.2-2.2-1.4-1.10.60.10.2-0.6-0.70.5-0.7-0.10.0
Pavlov. Cond. intertrial magazine entries0.10.30.80.3-0.20.20.1-0.20.50.5-0.7-0.9-0.80.70.5-0.70.70.90.1
Pavlov. Cond. lever-magazine prob. diff.2.23.46.3-2.5-2.42.42.52.12.21.9-1.5-1.1-1.31.51.7-1.51.61.11.0
Pavlov. Cond. response bias2.53.56.9-2.5-2.42.42.62.32.21.8-1.4-1.0-1.11.51.6-1.41.61.21.3
Time in closed arm before self-admin0.50.91.40.70.5-0.5-1.2-0.7-1.2-1.11.10.80.5-1.2-1.01.0-1.2-1.1-1.0
Time in closed arm after self-admin0.20.20.70.50.5-0.5-0.7-0.6-0.5-0.40.40.80.6-0.4-0.30.3-0.4-0.40.4
Time in open arm before self-admin2.53.15.3-2.3-2.22.22.21.92.11.8-1.6-0.9-0.71.71.7-1.61.61.21.1
Time in open arm after self-admin0.20.21.1-0.9-0.40.40.81.00.3-0.00.20.00.4-0.1-0.20.20.00.0-0.4
Bone: periosteal estimation1.02.54.0-1.3-1.61.61.60.81.82.0-1.8-1.6-1.81.71.4-1.81.71.20.8
Bone: periosteal perimeter0.51.01.8-0.3-0.80.80.90.21.11.2-1.2-1.2-1.31.20.9-1.31.21.20.6
Bone: post-yield work0.20.30.70.30.2-0.2-0.2-0.80.40.9-0.8-0.7-0.70.70.8-0.70.50.20.3
Progressive ratio test 1 active lever presses2.44.39.21.20.8-0.80.0-1.41.52.2-2.6-3.0-3.02.42.1-2.22.22.22.6
Progressive ratio test 1 breakpoint2.84.810.41.20.8-0.80.1-1.41.62.4-2.7-3.2-3.22.52.3-2.42.32.42.7
Progressive ratio test 1 inactive lever presses0.61.54.41.61.0-1.0-0.8-1.50.30.8-1.2-1.6-1.61.01.0-1.00.91.12.1
Progressive ratio test 2 active lever presses3.24.610.92.11.4-1.4-0.7-2.31.12.0-2.5-2.8-2.72.32.1-2.02.02.13.3
Progressive ratio test 2 breakpoint3.44.410.12.01.3-1.3-0.7-2.31.11.9-2.4-2.8-2.72.22.1-2.01.92.03.2
Progressive ratio test 2 inactive lever presses0.41.12.91.71.6-1.6-1.1-1.6-0.20.2-0.5-1.4-1.40.40.3-0.30.30.61.1
Incentive Sensitization - Responses0.51.44.21.71.2-1.2-1.1-2.00.10.8-1.1-1.4-1.50.90.9-0.80.60.71.6
Incentive Sensitization - Breakpoint0.61.44.01.71.2-1.2-1.1-2.00.10.8-1.1-1.4-1.40.90.9-0.80.60.81.6
Sum of active levers in priming session hrs 5-60.40.40.90.6-0.20.2-0.0-0.40.50.5-0.8-0.9-0.80.80.8-0.80.71.00.6
Progressive ratio0.10.20.90.40.3-0.3-0.3-0.4-0.00.2-0.2-0.9-0.80.10.1-0.20.10.10.3
Food seeking constrained by brief footshock1.51.95.5-2.2-2.02.02.22.31.50.9-0.6-0.0-0.30.80.7-0.71.00.70.7
Seeking ratio, punishment vs. effort0.30.72.5-1.5-1.31.31.31.60.60.20.11.00.70.10.1-0.00.30.10.1
Retroperitoneal fat weight2.09.113.4-2.8-3.43.43.72.63.53.2-2.9-2.8-2.83.03.0-3.03.12.81.3
Reaction time number correct0.51.63.31.70.5-0.5-0.5-1.50.50.9-1.4-1.8-1.71.31.3-1.21.21.51.5
Reaction time mean minus median0.32.27.6-2.8-2.32.31.72.60.5-0.20.61.11.2-0.5-0.40.3-0.4-0.7-1.6
Reaction time mean minus median AUC0.21.44.8-2.2-1.91.91.42.00.5-0.10.40.80.9-0.3-0.30.1-0.2-0.5-1.1
Reaction time num false alarms0.00.10.5-0.1-0.20.2-0.10.3-0.1-0.40.30.20.1-0.4-0.30.2-0.2-0.1-0.7
Reaction time num false alarms AUC0.00.00.20.3-0.00.0-0.4-0.2-0.1-0.20.0-0.1-0.1-0.2-0.0-0.1-0.10.1-0.4
Reaction time trials correct on left0.51.63.31.70.5-0.5-0.5-1.50.50.9-1.4-1.8-1.71.31.3-1.21.21.51.5
Reaction time trials on left0.41.53.01.60.4-0.4-0.5-1.50.50.9-1.3-1.7-1.61.21.2-1.21.11.51.4
Reaction time mean0.81.85.0-2.2-1.61.61.42.20.1-0.71.01.61.7-0.9-0.90.8-0.6-0.8-1.1
Reaction time mean AUC0.82.05.0-2.2-1.41.41.32.2-0.1-0.91.31.91.9-1.1-1.21.0-0.8-1.0-1.2
Median of all reaction times0.91.43.3-1.5-0.80.80.81.6-0.4-1.01.31.81.8-1.1-1.21.1-0.9-0.9-0.8
Reaction time omissions1.93.15.7-2.0-1.11.10.82.2-0.8-1.62.02.32.4-1.8-1.81.8-1.6-1.7-2.2
Reaction time false alarm rate0.10.20.6-0.6-0.50.50.10.7-0.1-0.30.40.50.5-0.5-0.40.2-0.3-0.3-0.7
Reaction time premature initiation rate3.75.88.32.02.9-2.9-2.6-1.8-2.8-2.52.52.12.2-2.6-2.62.6-2.5-2.2-0.8
Reaction time premature initiations1.13.37.02.62.6-2.6-2.5-2.3-2.1-1.61.30.91.0-1.5-1.51.5-1.5-1.00.1
Std. dev. reaction times0.82.69.2-3.0-2.62.62.12.90.8-0.00.51.21.3-0.4-0.40.2-0.2-0.5-1.5
Reaction time trials completed0.41.53.01.60.4-0.4-0.5-1.50.50.9-1.3-1.7-1.61.21.2-1.21.11.51.4
Reaction time trials AUC0.41.53.11.60.4-0.4-0.4-1.40.50.9-1.3-1.8-1.61.21.3-1.21.11.51.5
Run reversals in cocaine runway, females0.50.51.5-0.1-0.60.60.40.20.70.8-0.8-1.1-1.20.70.7-0.90.80.80.2
Run reversals in cocaine runway, males0.91.01.3-0.6-0.90.90.80.41.11.1-1.1-1.0-1.01.11.1-1.11.10.90.9
Latency to leave start box in cocaine runway0.71.02.0-0.80.4-0.40.30.8-0.8-1.01.41.20.8-1.3-1.31.4-1.1-1.3-0.6
Latency to leave start box in cocaine runway, F1.21.53.0-0.21.1-1.1-0.20.0-1.3-1.21.61.40.9-1.5-1.61.7-1.4-1.7-0.9
Latency to leave start box in cocaine runway, M0.50.52.4-1.3-0.80.80.81.50.1-0.40.60.60.5-0.5-0.20.4-0.4-0.4-0.3
Std. dev. time between licks in bursts0.20.41.4-1.2-1.01.01.01.10.60.4-0.20.30.30.10.4-0.20.30.10.2
Total sessions with >9 infusions1.41.83.71.91.3-1.3-1.0-1.90.30.9-1.3-1.8-1.71.11.0-1.00.91.11.7
Short access day 1 total inactive lever presses0.30.61.81.21.0-1.0-0.7-1.3-0.10.4-0.5-1.1-1.30.40.4-0.30.30.40.6
Short access day 10 total inactive lever presses0.00.30.7-0.8-0.70.70.70.70.0-0.20.30.80.7-0.3-0.20.2-0.2-0.4-0.7
Short access day 1 total infusions0.81.53.31.71.3-1.3-0.9-1.70.20.8-1.1-1.6-1.80.90.9-0.80.81.01.7
Short access day 10 total infusions1.42.35.01.60.8-0.8-0.6-1.60.81.3-1.7-2.0-2.11.61.5-1.51.41.62.2
Short access total infusions2.02.96.02.21.5-1.5-1.1-2.20.51.2-1.7-2.0-2.11.51.4-1.41.31.62.5
Short access day 1 locomotion0.40.72.0-0.2-0.10.10.4-0.20.81.2-1.1-1.2-1.40.90.9-0.90.90.50.8
Short access day 10 total locomotion0.10.30.7-0.1-0.10.10.1-0.30.50.8-0.8-0.5-0.70.80.6-0.80.50.30.1
Short access total locomotion1.21.83.50.5-0.00.00.1-1.01.11.6-1.8-1.7-1.91.61.6-1.71.31.11.7
One hour access (0.3 mA shock)2.32.85.41.21.2-1.2-0.1-1.61.11.9-2.1-2.0-1.82.01.7-1.71.71.72.3
Compulsive drug intake1.92.84.7-1.9-1.91.92.21.52.01.9-1.7-1.0-0.71.71.7-1.71.71.31.0
One hour access (shock baseline)0.71.96.32.52.2-2.2-1.6-2.5-0.50.2-0.7-1.3-1.40.50.4-0.30.30.61.0
Social response proportion2.93.75.82.02.0-2.0-2.4-1.9-2.4-2.21.91.21.5-2.1-1.81.9-2.1-1.8-1.2
Social responses0.10.10.40.50.3-0.3-0.4-0.7-0.2-0.1-0.0-0.2-0.0-0.00.2-0.0-0.1-0.00.1
Social time3.75.78.62.02.0-2.0-2.4-1.5-2.8-2.92.72.92.8-2.6-2.52.6-2.6-2.2-0.9
Soleus weight0.92.611.5-2.6-1.21.21.12.4-0.1-0.71.21.51.8-1.1-1.11.0-1.0-1.4-3.4
Bone: stiffness0.91.62.3-0.6-1.31.31.10.51.51.5-1.5-1.1-1.11.51.4-1.51.51.41.1
Tibialis anterior weight5.017.127.3-4.6-5.25.25.14.14.94.4-3.8-3.3-3.33.94.0-4.04.03.40.4
Time to tail flick, vehicle, before self-admin0.91.12.00.30.3-0.3-0.7-0.0-1.2-1.41.41.21.3-1.4-1.31.3-1.2-1.1-0.3
Time to tail flick, vehicle, after self-admin0.61.24.52.11.2-1.2-1.9-2.1-1.2-0.80.40.00.2-0.5-0.40.4-0.8-0.50.8
Time to tail flick, test, before self-admin0.91.12.6-1.6-0.70.70.71.4-0.3-0.61.01.11.5-1.0-1.00.9-0.8-1.1-1.3
Time to tail flick, test, after self-admin0.60.73.8-0.9-0.50.50.50.9-0.3-0.50.80.90.9-0.7-0.70.7-0.6-0.6-1.9
Delta time to tail flick, vehicle, before/after SA1.11.14.82.11.5-1.5-1.7-2.2-0.9-0.4-0.0-0.1-0.2-0.1-0.10.0-0.4-0.10.4
Delta time to tail flick, test, before/after SA0.10.10.20.3-0.10.10.1-0.20.20.2-0.4-0.2-0.30.40.4-0.40.30.5-0.2
Tibia length0.92.611.03.01.9-1.9-1.9-3.3-0.40.7-1.1-1.3-1.20.80.9-0.80.60.51.7
Ambulatory time before self-admin0.41.22.0-0.9-1.41.41.10.61.31.2-1.2-0.4-0.31.21.3-1.31.10.91.4
Ambulatory time after self-admin0.91.42.2-0.6-1.21.20.80.21.31.5-1.4-1.2-1.11.41.5-1.51.21.01.1
Bone: tissue strength1.41.43.2-0.30.1-0.1-0.30.8-1.1-1.61.61.71.8-1.4-1.41.4-1.3-1.0-1.0
Total heroin consumption0.30.30.9-0.8-0.90.90.60.70.40.3-0.1-0.8-0.50.10.2-0.20.20.1-0.9
Bone: trabecular number0.10.31.0-0.8-0.60.60.61.00.1-0.20.30.40.4-0.2-0.10.2-0.1-0.1-1.0
Bone: trabecular spacing0.50.72.51.31.3-1.3-1.1-1.6-0.40.1-0.4-0.4-0.40.20.2-0.2-0.0-0.01.2
Bone: trabecular thickness0.50.61.40.30.8-0.8-0.8-0.7-0.8-0.50.71.01.0-0.8-0.50.9-0.8-1.2-0.7
Bone: trabecular tissue density1.62.83.71.41.9-1.9-1.9-1.4-1.9-1.71.61.81.7-1.8-1.61.7-1.8-1.8-0.8
Water consumed over 24 hours0.20.30.9-0.9-0.50.50.70.50.70.8-0.6-0.6-0.50.40.5-0.50.40.0-0.5
Number of responses in last shaping day0.40.52.60.1-0.10.10.2-0.20.50.7-0.7-1.4-1.60.70.6-0.60.60.5-0.4