Hub : Genes

Bbs7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Bbs7 0.06 0.04 4.1e-06 0.03 0.03 0.03 0.03 8.9e-05 9.7e-05 2.5e-04 2.0e-04
2 Liver mRNA stability Bbs7 0.09 0.05 6.8e-09 0.06 0.06 0.04 0.06 4.6e-07 1.9e-07 1.3e-05 2.2e-07
3 PL gene expression Bbs7 0.1 0.07 2.4e-07 0.06 0.05 0.06 0.05 4.1e-07 1.3e-06 1.1e-06 1.7e-06
4 Brain gene expression Bbs7 0.18 0.1 4.4e-08 0.08 0.08 0.07 0.08 3.3e-08 5.3e-08 2.2e-07 1.4e-07
5 pVTA gene expression Bbs7 0.11 0.07 1.4e-03 0.03 0.07 0.04 0.06 1.4e-02 7.0e-04 7.4e-03 1.7e-03
6 LHb mRNA stability Bbs7 0.28 0.14 4.9e-04 0.12 0.13 0.12 0.12 7.3e-04 6.3e-04 8.0e-04 1.2e-03
7 Liver gene expression Bbs7 0.32 0.13 0.0e+00 0.18 0.22 0.21 0.22 9.7e-20 4.0e-24 7.9e-23 7.0e-24
8 NAcc mRNA stability Bbs7 0.08 0.05 1.7e-06 0.04 0.04 0.05 0.04 1.2e-05 7.4e-06 4.3e-06 2.1e-05
9 IL mRNA stability Bbs7 0.39 0.22 8.7e-05 0.2 0.19 0.18 0.2 1.4e-05 2.1e-05 4.5e-05 1.8e-05
10 Brain mRNA stability Bbs7 0.24 0.1 0.0e+00 0.25 0.25 0.24 0.24 9.6e-23 5.3e-23 3.7e-22 1.1e-22
11 IL gene expression Bbs7 0.27 0.15 7.2e-04 0.08 0.09 0.1 0.09 6.4e-03 2.9e-03 1.8e-03 3.9e-03
12 BLA mRNA stability Bbs7 0.32 0.2 3.6e-09 0.19 0.15 0.13 0.17 3.0e-10 3.3e-08 1.2e-07 1.7e-09
13 OFC mRNA stability Bbs7 0.31 0.14 1.9e-05 0.23 0.2 0.2 0.22 4.2e-06 1.4e-05 1.8e-05 5.7e-06
14 PL mRNA stability Bbs7 0.26 0.11 0.0e+00 0.16 0.18 0.17 0.17 9.2e-18 1.2e-19 1.7e-18 3.0e-18
15 PL isoform ratio XM_039102586.1 0.05 0.04 2.5e-04 0.02 0.03 0.03 0.03 1.7e-03 3.3e-04 4.2e-04 7.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.40.90.3-0.2-0.0-0.0-0.4-0.50.30.70.9-0.7-0.60.90.8-0.90.9
Area under the delay curve0.60.62.21.00.71.11.00.3-0.11.50.30.9-0.5-0.10.70.7-0.51.2
BMI with tail3.210.421.54.64.54.54.33.93.34.4-2.5-2.32.32.5-1.6-1.31.80.1
BMI without tail1.22.47.12.42.22.42.31.71.22.7-0.8-0.20.61.1-0.2-0.10.40.8
Body weight3.715.329.25.45.05.05.04.64.34.1-3.7-2.53.43.8-2.8-2.62.9-1.1
Weight adjusted by age0.00.10.3-0.6-0.3-0.2-0.2-0.2-0.3-0.20.10.3-0.2-0.00.10.10.00.1
Bone surface0.50.81.11.01.01.01.01.01.00.6-1.0-0.70.90.9-0.9-0.80.8-0.5
Bone volume0.00.00.20.50.10.10.10.10.2-0.0-0.00.20.0-0.1-0.0-0.0-0.2-0.0
Breakpoint value in progressive ratio session1.71.92.71.41.61.51.61.61.51.1-1.5-1.41.31.5-1.3-1.01.3-0.7
Number of licking bursts2.02.36.02.51.91.81.81.81.81.3-1.4-0.91.41.5-1.1-1.11.0-0.6
Context. condit. distance diff. score2.02.44.6-0.2-1.2-1.0-0.8-1.5-1.4-0.21.82.0-1.7-2.01.91.9-2.11.6
Locomotion velocity, session 12.12.24.00.61.00.60.71.31.6-0.4-1.8-2.01.81.6-1.9-1.91.8-1.9
Locomotion distance, session 13.14.05.91.31.91.61.62.12.20.5-2.3-2.42.32.1-2.3-2.22.3-1.9
Locomotion velocity, session 22.32.75.20.91.00.60.71.51.9-0.6-1.9-2.32.01.5-2.1-2.11.8-2.2
Locomotion distance, session 21.82.54.10.91.10.80.81.51.8-0.4-1.8-2.01.91.5-2.0-2.01.7-2.0
Locomotion velocity, session 30.00.00.1-0.10.10.10.10.10.2-0.1-0.2-0.30.20.0-0.2-0.20.3-0.3
Locomotion distance, session 30.10.10.30.2-0.0-0.1-0.10.10.3-0.5-0.3-0.30.3-0.0-0.4-0.40.2-0.5
Stereotopy head waving bouts, day 30.80.92.1-0.20.2-0.1-0.10.60.8-0.8-1.1-1.31.11.0-1.3-1.21.2-1.5
Stereotopy head waving duration, day 30.20.20.40.20.50.50.50.50.30.5-0.5-0.40.40.6-0.4-0.40.6-0.2
Locomotion velocity, session 71.11.22.10.60.70.50.41.01.3-0.3-1.3-1.31.41.2-1.4-1.41.3-1.5
Locomotion distance, session 70.81.02.7-0.9-1.4-1.5-1.5-1.1-0.7-1.60.80.5-0.5-1.00.40.4-0.8-0.3
Stereotopy head waving bouts, day 70.91.01.61.21.00.80.81.11.20.3-1.1-1.01.10.8-1.1-1.00.9-0.9
Stereotopy head waving duration, day 70.70.81.10.91.00.80.81.01.10.4-1.0-0.91.00.9-1.0-0.90.9-0.8
Locomotion velocity, session 80.30.31.11.10.60.70.70.40.21.00.10.2-0.1-0.30.40.3-0.40.6
Locomotion distance, session 80.10.21.21.10.40.30.50.30.50.2-0.10.10.2-0.2-0.0-0.1-0.3-0.0
Degree of sensitization distance1.51.52.6-1.2-1.6-1.6-1.6-1.4-1.1-1.41.20.8-1.0-1.30.90.9-1.20.3
Degree of sensitization stereotypy0.50.51.01.00.90.90.90.90.80.7-0.7-0.50.60.5-0.5-0.50.5-0.2
Conditioned locomotion2.32.74.1-2.0-2.0-1.9-1.8-1.9-1.9-1.41.71.5-1.6-1.51.41.3-1.50.8
Cocaine response after cond. corrected1.72.03.1-0.7-1.0-0.8-0.7-1.3-1.50.11.61.7-1.7-1.61.71.8-1.71.6
Cocaine response after cond. not corrected0.60.61.0-0.8-0.7-0.6-0.6-0.8-1.0-0.10.90.8-0.9-0.90.80.9-0.70.8
Cocaine response before conditioning2.12.55.10.11.21.01.01.51.50.2-1.9-2.01.81.9-2.0-1.92.2-1.7
Saline control response2.22.95.10.61.41.31.21.71.70.3-2.1-1.71.92.2-2.1-2.02.3-1.7
Bone: connectivity density0.81.22.21.51.41.41.41.31.21.1-1.0-0.80.91.1-0.7-0.80.8-0.3
Bone: cortical apparent density0.50.62.4-0.7-1.1-1.3-1.3-0.9-0.4-1.60.50.2-0.2-0.30.20.1-0.5-0.5
Bone: cortical area0.40.71.31.11.11.11.21.00.90.9-0.8-0.60.70.5-0.6-0.50.6-0.2
Bone: cortical porosity1.11.26.4-0.11.01.51.40.4-0.62.50.40.7-0.80.30.90.90.11.9
Bone: cortical porosity0.70.84.1-0.40.71.11.00.2-0.72.00.30.6-0.70.20.80.80.21.6
Bone: cortical thickness0.20.30.8-0.20.00.20.4-0.2-0.60.70.50.7-0.6-0.30.60.6-0.30.9
Bone: cortical thickness0.30.40.70.70.70.60.60.70.70.3-0.7-0.50.70.8-0.6-0.70.6-0.4
Bone: cortical tissue density0.50.72.7-0.7-1.2-1.3-1.3-0.9-0.4-1.60.50.2-0.2-0.30.10.1-0.5-0.6
Condit. Reinf. active minus inactive responses0.70.81.31.11.10.90.91.11.10.7-0.9-0.90.90.8-0.9-0.80.8-0.5
Condit. Reinf. active-inactive response ratio0.20.31.00.90.70.70.60.40.21.0-0.10.1-0.0-0.00.20.2-0.10.5
Condit. Reinf. active responses3.34.05.52.22.42.02.12.32.21.5-2.1-1.92.02.1-1.9-1.91.9-1.1
Condit. Reinf. inactive responses5.86.99.72.02.72.32.42.92.91.2-3.0-2.82.93.1-2.8-2.82.9-2.1
Incentive salience index mean0.81.01.41.21.10.90.91.21.20.6-1.1-1.01.10.9-1.0-1.00.9-0.7
Condit. Reinf. lever presses1.41.92.70.81.20.91.01.41.50.3-1.6-1.61.61.5-1.6-1.61.6-1.4
Condit. Reinf. active minus inactive responses1.11.42.00.81.31.21.21.31.10.8-1.3-1.31.21.3-1.2-1.11.4-0.8
Condit. Reinf. active-inactive response ratio0.30.30.5-0.4-0.4-0.2-0.2-0.5-0.70.10.70.7-0.7-0.60.70.7-0.60.7
Condit. Reinf. active responses3.85.27.21.62.32.12.02.52.41.0-2.6-2.62.52.6-2.5-2.42.7-1.9
Condit. Reinf. inactive responses8.510.513.62.63.33.02.93.63.61.5-3.7-3.53.53.6-3.5-3.43.6-2.6
Condit. Reinf. lever presses1.21.63.31.81.71.81.81.51.21.7-1.0-0.80.91.0-0.7-0.60.8-0.0
Condit. Reinf. lever reinforcers received3.44.86.31.72.22.02.02.42.41.0-2.5-2.42.42.4-2.3-2.32.5-1.8
Conditioned reinforcement - actives1.11.13.0-1.2-1.4-1.6-1.6-1.2-0.8-1.70.8-0.4-0.5-1.20.40.4-0.7-0.4
Conditioned reinforcement - inactives1.11.21.6-1.0-1.3-1.2-1.2-1.3-1.2-0.91.30.4-1.1-1.31.11.1-1.00.6
Conditioned locomotion1.11.44.00.90.3-0.1-0.20.71.4-1.1-1.2-2.01.40.4-1.6-1.50.7-1.8
Patch foraging indifference point 0 sec1.21.95.22.31.92.22.11.41.12.2-0.80.10.60.8-0.2-0.20.40.6
Patch foraging indifference point AUC1.01.22.50.40.80.50.51.01.1-0.0-1.3-1.01.31.6-1.4-1.31.4-1.3
Delay disc. indifference point, 0s delay0.60.61.7-0.7-0.4-0.8-0.70.00.3-1.3-0.7-0.90.70.4-1.0-1.00.7-1.3
Delay disc. indifference point, 16s delay0.40.41.51.20.81.00.90.60.41.1-0.20.60.00.20.10.1-0.10.5
Delay disc. indifference point, 2s delay0.30.31.00.70.50.90.70.30.11.00.00.6-0.20.00.30.4-0.20.7
Delay disc. indifference point, 24s delay0.90.91.8-0.4-0.7-0.4-0.5-0.9-1.00.01.11.3-1.1-1.11.21.1-1.21.1
Delay disc. indifference point, 4s delay0.91.02.61.21.31.61.51.10.71.6-0.7-0.10.50.9-0.3-0.30.60.4
Delay disc. indifference point, 8s delay0.80.91.90.1-0.30.10.0-0.6-0.90.61.01.4-1.1-0.91.31.3-1.11.3
Indifference point function ln k1.41.94.0-0.3-0.6-0.2-0.2-1.1-1.40.81.71.5-1.7-1.81.91.7-1.72.0
Indifference point function log k1.41.94.0-0.3-0.6-0.2-0.2-1.1-1.40.81.71.5-1.7-1.81.91.7-1.72.0
Patch foraging total patch changes 0 sec1.11.74.72.01.82.12.01.41.12.2-0.80.00.60.8-0.2-0.30.50.6
Patch foraging total patch changes 12 sec0.00.00.20.20.10.0-0.00.10.10.0-0.10.50.10.5-0.2-0.10.1-0.1
Patch foraging total patch changes 18 sec0.81.02.41.51.21.21.11.21.11.0-1.0-0.70.91.0-0.7-0.60.8-0.3
Patch foraging total patch changes 24 sec2.73.36.42.52.42.42.42.11.92.0-1.7-0.81.61.7-1.2-1.11.4-0.4
Patch foraging total patch changes 6 sec1.01.53.41.51.71.81.81.41.11.8-1.0-0.10.81.3-0.6-0.61.00.1
Patch foraging time to switch 0 sec0.81.21.9-1.2-1.4-1.4-1.4-1.3-1.0-1.31.10.6-0.9-1.30.80.9-1.00.2
Patch foraging water rate 0 sec0.10.10.60.20.40.50.40.3-0.00.8-0.10.4-0.10.40.0-0.10.20.4
Patch foraging water rate 12 sec0.40.61.10.20.60.60.50.80.70.2-0.9-0.90.81.0-0.9-1.01.0-0.7
Patch foraging water rate 18 sec0.71.01.51.01.01.00.91.11.10.5-1.1-0.91.11.2-1.0-1.01.1-0.7
Patch foraging water rate 24 sec0.81.11.71.00.90.70.71.11.20.2-1.2-0.81.21.3-1.3-1.31.1-1.1
Patch foraging water rate 6 sec0.20.20.50.10.40.50.50.40.40.2-0.5-0.50.50.7-0.5-0.60.7-0.4
Seeking ratio, delayed vs. immediate footshock1.71.94.72.11.92.12.21.51.22.0-1.0-0.90.80.7-0.5-0.50.60.3
Distance traveled before self-admin0.60.71.31.10.90.90.81.00.90.6-0.9-0.30.80.9-0.8-0.80.6-0.4
Distance traveled after self-admin2.12.35.62.41.81.71.61.71.81.2-1.5-1.31.41.3-1.2-1.51.0-0.7
Extensor digitorum longus weight2.610.220.34.54.34.44.43.83.24.2-2.6-1.92.32.8-1.7-1.72.1-0.1
Bone: elastic displacement3.74.27.6-0.9-1.3-0.8-0.8-1.8-2.20.72.52.3-2.5-2.22.82.6-2.42.7
Bone: elastic work3.44.46.3-1.6-1.8-1.5-1.4-2.2-2.4-0.22.52.4-2.5-2.32.52.4-2.32.2
Bone: endosteal estimation1.63.55.52.32.01.71.72.12.40.8-2.0-2.12.11.4-1.9-1.81.5-1.5
Bone: endosteal perimeter1.22.54.51.21.41.11.11.61.80.1-1.8-2.11.81.4-1.8-1.81.7-1.7
Epididymis fat weight3.17.29.32.43.02.92.83.13.01.7-2.9-2.42.83.0-2.6-2.62.8-1.8
Delta time in closed arm before/after self-admin1.01.01.50.91.10.90.81.21.10.5-1.2-0.81.11.2-1.2-1.01.1-0.8
Delta time in open arm before/after self-admin0.40.41.4-0.9-0.6-0.3-0.2-0.7-0.80.00.71.2-0.7-0.40.80.6-0.40.7
Diff in mean of infusions in LGA sessions0.50.62.01.31.01.11.10.70.41.4-0.1-0.10.00.10.20.4-0.10.7
Delay discount exponential model param0.70.82.4-0.9-0.6-1.0-1.0-0.20.2-1.6-0.5-1.00.60.3-0.9-0.90.7-1.4
Extinction: sum of active levers before priming0.60.61.20.40.60.40.50.81.0-0.0-1.0-0.61.01.0-1.1-0.90.9-0.9
Active lever presses in extinction session 60.10.10.20.40.30.40.40.20.20.4-0.1-0.20.10.2-0.00.10.00.1
Bone: final force1.93.05.31.92.22.22.32.11.72.0-1.7-1.01.41.9-1.3-1.31.6-0.4
Bone: final moment1.62.64.92.02.12.22.21.91.52.0-1.5-0.71.21.7-1.0-1.01.3-0.2
Food consumed during 24 hour testing period0.20.21.51.20.50.30.40.40.60.2-0.2-0.30.30.1-0.1-0.2-0.2-0.1
Glucose0.10.20.7-0.6-0.6-0.6-0.8-0.5-0.3-0.80.20.0-0.2-0.4-0.0-0.1-0.2-0.3
Heart weight0.71.03.60.61.41.61.61.10.51.9-0.6-0.70.40.7-0.2-0.30.80.6
Delay discount hyperbolic model param0.70.72.3-0.9-0.6-1.0-0.9-0.20.2-1.5-0.4-1.00.60.2-0.9-0.90.6-1.3
Intermittent access intake day 1-15 change1.71.73.7-1.8-1.8-1.9-1.9-1.5-1.3-1.91.0-0.4-0.9-1.30.60.6-0.7-0.2
Intermittent access intake escalation1.91.93.4-1.8-1.8-1.7-1.8-1.6-1.5-1.51.3-0.1-1.2-1.51.01.0-1.00.3
Intermittent access intake escalation 20.50.50.8-0.8-0.9-0.8-0.9-0.8-0.7-0.80.6-0.5-0.5-0.90.40.4-0.50.0
Intermitt. access day 1 inactive lever presses0.10.10.3-0.5-0.3-0.5-0.4-0.2-0.2-0.40.1-0.1-0.1-0.1-0.0-0.1-0.0-0.1
Intermitt. access day 15 inactive lever presses0.50.63.4-1.9-0.8-0.6-0.7-0.7-1.1-0.20.7-0.2-0.8-0.50.60.7-0.10.5
Intermitt. access escalation Index0.00.00.10.20.20.20.30.20.20.2-0.20.00.30.3-0.1-0.10.4-0.1
Intermittent access day 1 total infusions0.80.93.9-1.2-1.0-1.2-1.3-0.5-0.0-2.0-0.2-0.80.4-0.2-0.7-0.70.3-1.4
Intermittent access day 15 total infusions1.51.75.9-1.8-1.8-1.9-1.9-1.3-0.8-2.40.6-1.0-0.3-1.10.00.1-0.3-1.0
Intermittent access terminal intake (last 3 days)2.02.28.3-2.0-1.8-2.1-2.2-1.2-0.6-2.90.2-1.50.0-0.9-0.4-0.4-0.0-1.5
Intermittent access total infusions1.31.44.1-1.2-0.7-1.0-1.1-0.10.4-2.0-0.8-1.81.00.3-1.3-1.21.0-1.9
Intermittent access day 1 locomotion0.50.61.50.70.2-0.1-0.10.41.0-0.8-0.8-1.00.90.4-1.0-1.00.4-1.2
Intermittent access day 15 total locomotion0.40.41.90.8-0.2-0.4-0.4-0.10.5-1.0-0.2-1.40.4-0.7-0.4-0.4-0.2-0.9
Intermittent access total locomotion1.11.23.40.90.40.00.00.71.4-0.9-1.2-1.91.30.4-1.5-1.50.7-1.7
Intermittent access standard deviation0.70.81.6-1.3-0.9-0.6-0.6-0.9-1.2-0.21.00.4-1.0-0.91.01.0-0.60.8
Left kidney weight0.00.10.30.60.30.30.40.30.40.1-0.20.10.30.1-0.2-0.40.1-0.2
Right kidney weight0.30.81.91.41.11.21.21.01.00.9-0.7-0.60.70.6-0.4-0.50.5-0.2
Cocaine induced anxiety1.21.42.31.51.41.11.11.41.50.7-1.3-1.51.20.8-1.1-1.10.9-0.8
Post-drug Anxiety1.92.13.01.41.71.61.61.71.61.2-1.6-1.51.41.5-1.3-1.31.4-0.7
Baseline Anxiety0.60.62.4-0.2-0.30.10.1-0.6-0.90.60.81.5-0.9-0.31.01.0-0.61.2
Tail length0.10.20.60.80.40.50.60.30.30.3-0.30.70.20.5-0.1-0.20.2-0.0
Length with tail0.72.55.22.31.92.02.21.81.81.4-1.6-0.31.51.7-1.2-1.31.3-0.6
Length without tail1.94.27.62.82.52.42.52.42.41.7-2.0-1.52.02.0-1.7-1.71.7-1.0
Times rat made contact with spout0.10.20.70.4-0.3-0.6-0.5-0.10.3-0.80.1-0.40.2-0.4-0.1-0.1-0.4-0.5
Lifetime Intake1.21.43.8-1.2-0.6-0.9-1.0-0.10.4-1.9-0.8-1.81.00.4-1.3-1.21.1-1.9
Liver weight, left0.10.20.40.60.0-0.1-0.10.20.5-0.5-0.4-0.20.50.3-0.4-0.50.1-0.7
Liver weight, right0.00.10.1-0.3-0.3-0.3-0.4-0.3-0.2-0.40.2-0.0-0.1-0.10.20.1-0.1-0.0
Locomotor activity0.10.10.5-0.70.10.30.30.1-0.40.60.00.0-0.20.30.1-0.00.40.4
Locomotor testing distance2.44.06.71.52.52.62.52.41.72.5-1.9-1.71.62.2-1.4-1.52.2-0.3
Locomotor testing rearing0.10.20.9-0.30.50.70.70.4-0.10.9-0.3-0.10.00.5-0.1-0.10.60.4
Locomotion in novel chamber1.92.35.52.31.91.71.71.81.71.4-1.5-0.91.41.6-1.2-1.31.1-0.6
Locomotion in novel chamber post-restriction0.00.00.2-0.10.20.20.20.1-0.20.50.00.2-0.20.20.10.00.10.3
Fecal boli incidents, locomotor time 11.61.72.7-1.6-1.6-1.5-1.4-1.6-1.5-1.21.30.9-1.2-1.61.11.1-1.10.6
Change in fecal boli incidents, locomotor task2.12.03.11.21.41.01.01.51.60.4-1.7-1.21.61.7-1.7-1.71.4-1.3
Time >=10cm from walls, locomotor time 10.40.40.9-0.20.1-0.2-0.20.40.5-0.5-0.7-0.40.70.8-0.9-1.00.8-1.0
Bouts of movement, locomotor time 11.21.32.5-0.9-1.3-1.4-1.3-1.3-1.2-1.01.30.5-1.1-1.61.11.2-1.10.5
Total resting periods, locomotor time 12.42.64.2-1.4-1.8-1.7-1.6-1.9-1.8-1.11.91.2-1.6-2.11.61.7-1.61.0
Rest time, locomotor task time 11.51.62.7-1.2-1.6-1.5-1.5-1.5-1.3-1.31.30.8-1.2-1.71.11.1-1.30.4
Distance moved, locomotor task time 12.42.73.51.81.91.61.61.91.91.1-1.8-1.31.71.8-1.6-1.71.5-1.0
Vertical activity count, locomotor time 12.32.44.22.02.01.91.81.91.71.6-1.4-1.01.41.7-1.1-1.31.2-0.4
Time >=10cm from walls, locomotor time 20.30.31.0-0.9-0.7-1.0-0.9-0.5-0.3-1.00.1-0.0-0.0-0.3-0.1-0.2-0.0-0.5
Bouts of movement, locomotor time 23.43.75.2-2.0-2.2-2.1-2.0-2.2-2.2-1.32.21.0-2.0-2.32.01.9-1.81.2
Total resting periods, locomotor time 22.72.83.9-1.7-1.8-1.7-1.6-1.9-2.0-0.92.00.9-1.8-2.01.81.8-1.61.2
Rest time, locomotor task time 20.30.40.8-0.4-0.4-0.2-0.3-0.6-0.70.10.80.7-0.7-0.70.80.9-0.60.7
Distance moved, locomotor task time 21.61.82.91.21.31.00.91.41.60.3-1.6-1.31.51.4-1.7-1.71.3-1.3
Vertical activity count, locomotor time 22.32.55.30.91.20.60.71.51.8-0.2-1.9-1.61.91.7-2.1-2.31.7-1.9
Light reinforcement 10.20.31.5-1.2-0.7-0.5-0.5-0.6-0.7-0.50.30.5-0.4-0.00.20.20.10.1
Light reinforcement 20.20.20.6-0.7-0.7-0.7-0.6-0.6-0.4-0.80.40.3-0.2-0.30.20.1-0.2-0.2
Bone: marrow area1.63.45.92.42.01.81.72.12.40.8-2.0-2.02.01.3-1.8-1.81.4-1.4
Bone: maximum diameter0.71.21.91.31.21.01.11.31.40.5-1.2-1.31.20.8-1.1-1.11.0-0.9
Bone: maximum force0.50.91.91.21.31.31.41.10.91.1-0.9-0.40.81.0-0.6-0.60.8-0.1
Bone: maximum moment0.40.71.71.21.21.31.31.00.81.2-0.7-0.10.50.8-0.4-0.40.50.1
Mean time between licks in bursts0.00.00.10.20.0-0.00.10.00.10.00.00.30.00.2-0.0-0.0-0.0-0.0
Mean num. licks in bursts1.72.03.9-2.0-1.8-1.8-1.8-1.7-1.6-1.31.30.6-1.3-1.61.01.1-1.10.5
Cd content in liver0.50.52.1-1.4-0.9-1.0-1.0-0.6-0.4-1.20.1-0.4-0.0-0.3-0.2-0.20.2-0.6
Co content in liver0.30.40.50.50.70.70.70.70.70.4-0.6-0.60.60.6-0.5-0.60.6-0.4
Cu content in liver0.30.40.80.90.70.60.60.70.80.3-0.6-0.50.70.5-0.5-0.60.4-0.5
Fe content in liver0.40.51.2-0.6-0.30.00.0-0.5-0.90.60.61.0-0.9-0.40.80.9-0.41.1
K content in liver0.50.41.0-0.6-0.9-0.9-0.9-0.8-0.6-0.80.61.0-0.5-0.40.40.4-0.60.1
Mg content in liver1.01.02.0-0.8-1.2-1.1-1.1-1.2-1.0-0.81.11.4-1.0-0.90.90.9-1.10.5
Mn content in liver2.22.53.5-1.5-1.8-1.8-1.8-1.9-1.7-1.21.61.5-1.6-1.71.41.6-1.60.9
Na content in liver1.31.42.61.21.21.11.11.31.40.4-1.3-0.71.31.6-1.2-1.21.1-1.0
Rb content in liver0.30.42.00.30.70.90.90.3-0.11.40.10.7-0.30.60.40.20.10.9
Se content in liver1.01.24.1-1.8-1.1-1.3-1.3-0.6-0.2-2.0-0.4-0.90.50.1-0.9-0.80.8-1.5
Sr content in liver0.80.71.60.20.40.30.30.70.9-0.5-1.0-1.11.10.7-1.1-1.21.1-1.3
Zn content in liver1.01.12.4-0.2-0.9-0.7-0.7-1.0-1.0-0.21.31.6-1.2-1.21.31.2-1.41.0
Bone: minimum diameter1.01.93.41.81.71.61.71.71.61.2-1.3-1.41.30.7-1.1-1.01.0-0.6
Time in familiar zone, hab. session 10.20.20.6-0.1-0.2-0.4-0.4-0.00.3-0.8-0.2-0.60.4-0.1-0.5-0.50.2-0.7
Time in novel zone, hab. session 10.10.10.5-0.10.40.50.50.30.00.6-0.30.00.10.7-0.1-0.20.50.1
Total zone transitions, hab. session 11.31.84.71.41.82.12.11.51.02.2-0.9-0.60.71.1-0.4-0.51.00.4
Total locomotion distance, hab. session 11.41.93.11.01.81.81.71.61.21.6-1.4-1.11.21.6-1.1-1.01.6-0.3
Locomotion velocity, hab. session 11.21.73.61.11.81.81.81.51.01.9-1.1-0.80.91.4-0.8-0.71.30.0
Time in familiar zone, hab. session 21.92.06.0-2.4-1.8-1.7-1.7-1.7-1.7-1.41.20.8-1.2-1.10.91.0-0.70.4
Time in novel zone, hab. session 21.61.64.72.21.71.61.71.51.41.5-1.0-0.61.00.9-0.7-0.70.6-0.1
Total zone transitions, hab. session 23.24.15.52.02.32.22.22.42.21.4-2.2-1.92.12.2-1.9-1.92.1-1.2
Total locomotion distance, hab. session 22.22.84.01.41.91.81.71.91.71.3-1.8-1.61.72.0-1.6-1.61.9-0.9
Locomotion velocity, hab. session 22.83.85.31.62.11.91.82.22.11.2-2.2-1.92.02.3-2.0-1.92.2-1.3
Novel to familiar place preference ratio1.51.64.20.2-0.10.30.2-0.7-1.11.31.31.8-1.5-1.01.71.6-1.42.1
Novelty place preference1.92.05.20.2-0.20.20.2-0.8-1.31.41.52.0-1.7-1.21.91.8-1.62.3
Time in novel zone, NPP test1.91.95.40.50.10.50.5-0.6-1.11.71.41.9-1.6-1.01.81.8-1.52.3
Total zone transitions, NPP test1.92.74.60.61.20.91.01.61.7-0.1-1.9-2.12.01.9-2.1-2.02.1-1.9
Total locomotion distance, NPP test1.62.13.70.31.00.70.71.31.5-0.2-1.7-1.81.71.8-1.9-1.81.9-1.8
Locomotion velocity, NPP test1.31.93.6-0.10.70.40.51.11.2-0.4-1.6-1.81.61.7-1.8-1.71.9-1.8
Intraocular pressure0.30.41.3-1.1-0.8-0.8-0.8-0.7-0.8-0.50.50.3-0.5-0.30.40.6-0.20.2
Delta distance traveled before/after self-admin0.20.20.80.90.50.40.50.40.50.3-0.2-0.60.30.0-0.1-0.30.0-0.1
Delta ambulatory time before/after self-admin0.10.10.40.60.40.30.40.30.40.3-0.2-0.60.30.1-0.2-0.30.1-0.1
Parametrial fat weight0.40.81.41.00.70.60.50.91.1-0.0-1.0-1.21.00.8-1.1-1.00.7-1.0
Pavlov. Cond. lever latency1.01.32.3-0.8-0.8-0.4-0.5-1.1-1.40.31.31.5-1.4-1.01.51.4-1.21.5
Pavlov. Cond. magazine entry latency1.31.63.51.91.41.21.31.51.70.7-1.3-1.21.41.0-1.2-1.10.9-0.9
Pavlov. Cond. change in total contacts0.80.91.40.80.80.50.51.01.2-0.0-1.1-1.11.20.9-1.2-1.21.0-1.1
Pavlov. Cond. index score2.73.55.51.91.71.21.32.02.30.1-2.1-2.22.21.7-2.1-2.11.8-2.0
Pavlov. Cond. latency score2.43.14.81.61.41.01.11.82.2-0.1-2.0-2.22.11.6-2.1-2.11.7-2.0
Pavlov. Cond. lever contacts1.82.13.51.11.00.60.61.41.8-0.3-1.7-1.81.81.2-1.8-1.81.5-1.9
Pavlov. Cond. magazine entry number2.43.06.6-2.6-1.9-1.5-1.6-2.0-2.3-0.71.81.7-1.9-1.31.71.7-1.21.4
Pavlov. Cond. intertrial magazine entries0.60.71.2-1.1-0.9-1.0-0.9-1.0-1.0-0.50.80.7-0.8-0.70.70.7-0.60.5
Pavlov. Cond. lever-magazine prob. diff.2.63.25.11.91.61.21.31.92.20.2-2.0-2.12.11.6-2.0-2.01.7-1.8
Pavlov. Cond. response bias2.22.75.12.31.61.21.31.82.20.4-1.8-1.71.91.2-1.7-1.71.2-1.5
Pavlov. Cond. lever latency3.24.36.7-2.6-2.6-2.6-2.5-2.5-2.2-2.12.01.6-1.8-2.11.51.6-1.70.7
Pavlov. Cond. magazine entry latency0.60.72.81.70.71.01.00.40.21.30.30.6-0.4-0.30.70.7-0.81.1
Pavlov. Cond. change in total contacts3.95.48.62.62.92.92.92.72.42.3-2.3-1.82.02.5-1.8-1.82.1-0.8
Pavlov. Cond. index score3.44.410.23.22.72.82.82.52.22.4-1.8-1.31.61.8-1.2-1.21.3-0.3
Pavlov. Cond. latency score2.83.58.62.92.42.52.42.22.02.1-1.6-1.21.51.6-1.1-1.11.1-0.3
Pavlov. Cond. lever contacts3.85.17.82.82.82.72.72.72.52.1-2.3-1.72.12.4-1.8-1.81.9-0.9
Pavlov. Cond. magazine entry number2.02.48.1-2.9-2.1-2.3-2.3-1.7-1.4-2.30.90.3-0.7-0.80.30.3-0.2-0.6
Pavlov. Cond. intertrial magazine entries0.20.30.7-0.10.30.10.10.50.5-0.2-0.7-0.80.70.5-0.8-0.80.8-0.8
Pavlov. Cond. lever-magazine prob. diff.3.44.39.43.12.72.72.72.52.32.2-1.9-1.41.71.8-1.4-1.31.4-0.5
Pavlov. Cond. response bias3.14.38.02.82.72.82.82.42.12.5-1.8-1.11.62.0-1.2-1.31.5-0.2
Time in closed arm before self-admin0.91.01.4-1.1-1.2-1.2-1.2-1.1-1.2-0.71.10.3-1.0-1.21.00.9-0.90.6
Time in closed arm after self-admin0.20.20.9-0.5-0.5-0.7-0.8-0.2-0.0-0.9-0.2-0.20.20.1-0.5-0.30.2-0.7
Time in open arm before self-admin2.52.77.82.82.22.22.11.91.71.9-1.4-0.51.21.4-0.9-1.00.8-0.1
Time in open arm after self-admin0.40.51.50.80.91.11.20.60.41.2-0.20.30.10.40.1-0.00.20.5
Bone: periosteal estimation1.12.24.22.01.71.61.61.81.80.9-1.6-1.51.50.9-1.4-1.31.1-0.9
Bone: periosteal perimeter0.71.21.90.51.00.90.91.21.10.4-1.3-1.41.21.1-1.3-1.21.4-1.0
Bone: post-yield work0.40.51.00.80.40.20.20.60.9-0.5-0.8-0.80.90.4-0.9-0.90.5-1.0
Progressive ratio test 1 active lever presses1.92.05.00.20.80.30.31.11.5-0.5-1.6-2.21.71.3-1.8-1.81.6-1.9
Progressive ratio test 1 breakpoint2.02.15.60.20.70.20.21.11.5-0.7-1.6-2.41.71.3-1.9-1.91.6-2.0
Progressive ratio test 1 inactive lever presses0.91.02.5-0.5-0.0-0.4-0.40.40.7-1.1-0.9-1.61.10.9-1.3-1.31.2-1.6
Progressive ratio test 2 active lever presses1.21.34.3-0.9-0.7-1.1-1.1-0.20.4-2.1-0.7-1.80.90.1-1.2-1.10.8-1.9
Progressive ratio test 2 breakpoint1.41.54.4-0.6-0.4-0.8-0.90.10.8-1.9-1.0-2.01.20.4-1.5-1.51.0-2.1
Progressive ratio test 2 inactive lever presses0.80.93.0-1.4-1.1-1.3-1.4-0.8-0.4-1.70.2-1.20.0-0.5-0.2-0.20.1-0.9
Incentive Sensitization - Responses0.80.83.3-0.4-0.7-1.0-1.1-0.30.3-1.8-0.4-1.30.6-0.2-0.8-0.70.3-1.5
Incentive Sensitization - Breakpoint0.80.83.5-0.5-0.7-1.0-1.1-0.30.3-1.9-0.4-1.30.6-0.2-0.8-0.80.3-1.5
Sum of active levers in priming session hrs 5-60.60.61.4-0.60.1-0.2-0.20.40.5-0.7-0.9-0.90.80.8-1.1-0.91.0-1.2
Progressive ratio0.20.20.8-0.1-0.2-0.4-0.50.00.2-0.7-0.2-0.90.3-0.1-0.4-0.40.2-0.6
Food seeking constrained by brief footshock1.51.95.11.61.92.22.21.51.12.3-0.9-0.30.71.2-0.4-0.30.70.5
Seeking ratio, punishment vs. effort0.81.03.51.21.21.61.60.80.41.9-0.30.80.10.70.20.30.10.9
Retroperitoneal fat weight1.75.58.32.02.42.22.02.62.71.1-2.6-2.92.52.6-2.3-2.42.4-1.9
Reaction time number correct1.21.84.4-1.0-0.1-0.6-0.60.50.8-1.5-1.4-1.81.41.2-1.8-1.81.7-2.1
Reaction time mean minus median1.52.07.21.71.31.81.90.6-0.02.70.41.4-0.8-0.31.11.1-0.92.1
Reaction time mean minus median AUC1.01.34.61.51.11.51.70.60.12.10.21.0-0.5-0.20.80.8-0.61.5
Reaction time num false alarms0.00.00.1-0.20.10.10.10.0-0.20.40.1-0.1-0.1-0.00.10.10.10.3
Reaction time num false alarms AUC0.00.00.1-0.3-0.0-0.1-0.00.1-0.1-0.0-0.1-0.30.10.1-0.2-0.20.3-0.1
Reaction time trials correct on left1.21.84.4-1.0-0.1-0.6-0.60.50.8-1.5-1.4-1.81.41.2-1.8-1.81.7-2.1
Reaction time trials on left1.11.64.0-0.9-0.1-0.6-0.60.40.8-1.4-1.3-1.71.31.2-1.7-1.71.6-2.0
Reaction time mean1.21.75.71.20.91.51.60.3-0.42.40.61.8-1.0-0.31.31.3-0.92.1
Reaction time mean AUC1.41.95.71.00.81.41.50.1-0.62.40.81.9-1.2-0.51.51.5-1.02.3
Median of all reaction times1.01.33.70.60.51.01.0-0.1-0.71.80.81.8-1.1-0.41.31.3-0.91.9
Reaction time omissions2.63.69.80.5-0.00.60.6-0.8-1.62.12.02.6-2.2-1.62.62.6-2.13.1
Reaction time false alarm rate0.10.20.60.30.30.40.50.1-0.20.80.20.3-0.3-0.10.40.4-0.20.7
Reaction time premature initiation rate3.85.17.3-2.6-2.6-2.4-2.2-2.7-2.6-1.62.52.2-2.2-2.42.22.0-2.01.3
Reaction time premature initiations2.02.87.2-2.7-2.3-2.3-2.2-2.0-1.7-2.21.41.0-1.2-1.30.90.7-0.8-0.0
Std. dev. reaction times1.72.48.92.01.62.22.20.90.23.00.31.5-0.6-0.21.01.1-0.82.1
Reaction time trials completed1.11.64.0-0.9-0.1-0.6-0.60.40.8-1.4-1.3-1.71.31.2-1.7-1.71.6-2.0
Reaction time trials AUC1.11.63.9-0.9-0.1-0.5-0.60.50.8-1.3-1.3-1.71.31.2-1.7-1.71.6-2.0
Run reversals in cocaine runway, females0.70.61.70.70.80.50.50.90.80.3-0.8-1.30.90.7-0.8-1.00.8-0.7
Run reversals in cocaine runway, males1.00.91.51.01.10.90.91.11.10.6-1.0-0.91.01.2-1.0-1.00.9-0.6
Latency to leave start box in cocaine runway0.91.02.40.6-0.10.30.2-0.6-0.80.91.20.9-1.1-0.91.51.4-1.21.6
Latency to leave start box in cocaine runway, F1.01.12.20.1-0.7-0.3-0.4-1.1-1.0-0.01.30.9-1.2-1.41.51.4-1.51.2
Latency to leave start box in cocaine runway, M0.50.51.30.0-0.10.10.1-0.4-0.70.70.90.9-0.8-0.41.00.9-0.71.2
Std. dev. time between licks in bursts0.30.41.21.10.80.90.90.70.51.1-0.20.30.20.6-0.0-0.10.10.4
Total sessions with >9 infusions0.00.00.1-0.1-0.1-0.2-0.2-0.1-0.0-0.30.0-0.40.1-0.0-0.0-0.00.0-0.2
Short access day 1 total inactive lever presses0.91.03.30.30.40.0-0.00.71.0-0.7-1.1-1.81.20.8-1.3-1.21.0-1.4
Short access day 10 total inactive lever presses0.00.00.0-0.10.00.0-0.00.00.00.0-0.00.10.00.2-0.0-0.00.0-0.0
Short access day 1 total infusions0.40.52.4-0.10.2-0.0-0.10.40.5-0.5-0.6-1.50.70.4-0.8-0.70.7-1.0
Short access day 10 total infusions0.40.41.3-0.60.1-0.1-0.10.30.4-0.4-0.7-1.10.70.7-0.8-0.80.9-0.9
Short access total infusions0.70.82.1-0.9-0.3-0.6-0.60.10.4-1.3-0.7-1.40.80.6-1.1-1.01.0-1.5
Short access day 1 locomotion0.80.82.91.71.11.11.01.01.10.8-0.7-1.00.80.5-0.5-0.50.3-0.2
Short access day 10 total locomotion0.10.10.60.80.50.40.40.30.20.7-0.00.1-0.1-0.20.00.0-0.40.5
Short access total locomotion0.20.20.50.50.2-0.1-0.10.30.6-0.4-0.5-0.70.50.3-0.7-0.70.2-0.7
One hour access (0.3 mA shock)1.41.75.1-0.1-0.1-0.5-0.50.41.1-1.8-1.4-1.41.51.0-1.8-1.81.3-2.3
Compulsive drug intake4.14.17.02.62.42.22.22.32.41.5-2.1-1.22.12.3-1.8-1.81.8-1.1
One hour access (shock baseline)1.61.96.6-2.2-1.9-2.0-2.0-1.4-0.8-2.60.5-0.6-0.3-1.0-0.0-0.1-0.2-1.0
Social response proportion4.04.36.9-2.6-2.6-2.4-2.4-2.4-2.3-2.02.01.4-1.9-2.31.71.6-1.80.7
Social responses0.10.10.4-0.5-0.4-0.5-0.5-0.3-0.1-0.60.1-0.1-0.0-0.1-0.1-0.1-0.0-0.3
Social time4.86.310.4-3.2-2.8-2.5-2.4-2.9-3.1-1.52.72.6-2.7-2.32.42.2-2.11.7
Soleus weight0.72.06.61.71.01.41.50.3-0.32.60.81.7-1.0-0.41.51.4-1.22.3
Bone: stiffness0.81.21.71.01.21.21.21.31.20.7-1.3-0.71.21.3-1.2-1.11.2-0.7
Tibialis anterior weight5.117.429.45.45.35.15.15.04.64.2-4.0-3.23.74.0-3.1-3.13.3-1.4
Time to tail flick, vehicle, before self-admin0.90.92.6-0.2-0.20.00.2-0.6-1.11.01.21.3-1.2-0.61.41.0-0.91.6
Time to tail flick, vehicle, after self-admin1.21.33.9-1.7-1.6-1.7-1.8-1.2-0.8-2.00.50.3-0.4-0.70.00.2-0.4-0.6
Time to tail flick, test, before self-admin0.90.92.10.6-0.00.20.3-0.4-0.70.91.01.4-1.0-0.81.31.3-1.11.4
Time to tail flick, test, after self-admin0.80.82.1-0.1-0.10.30.2-0.5-0.80.91.01.1-1.1-0.91.31.1-0.91.4
Delta time to tail flick, vehicle, before/after SA2.12.17.9-2.3-2.0-2.1-2.3-1.4-0.8-2.80.4-0.1-0.2-0.9-0.30.1-0.2-1.2
Delta time to tail flick, test, before/after SA0.00.00.3-0.5-0.2-0.1-0.2-0.2-0.1-0.30.0-0.1-0.0-0.1-0.0-0.20.1-0.1
Tibia length0.82.29.9-1.3-1.4-1.8-1.8-0.50.4-3.2-0.6-1.21.00.1-1.4-1.40.7-2.5
Ambulatory time before self-admin0.70.71.11.00.70.60.50.91.00.1-1.0-0.60.91.0-1.0-1.00.8-0.8
Ambulatory time after self-admin1.21.32.31.51.10.90.91.21.40.3-1.2-1.21.21.1-1.2-1.40.9-0.9
Bone: tissue strength1.51.43.4-0.8-0.5-0.1-0.1-0.9-1.50.91.31.8-1.5-0.81.51.5-1.01.8
Total heroin consumption0.20.20.70.40.60.70.70.50.30.8-0.2-0.40.10.2-0.00.00.20.3
Bone: trabecular number0.10.10.40.10.20.40.3-0.0-0.30.70.30.4-0.4-0.10.50.4-0.20.7
Bone: trabecular spacing0.30.42.1-0.5-0.7-1.0-1.0-0.40.1-1.5-0.1-0.40.3-0.3-0.4-0.40.0-1.0
Bone: trabecular thickness0.60.81.80.0-0.9-0.9-0.9-1.0-0.6-0.81.01.1-0.8-1.00.90.8-1.30.4
Bone: trabecular tissue density2.33.24.3-1.7-2.0-1.8-1.9-2.1-2.0-1.21.92.0-1.9-1.61.71.7-1.81.2
Water consumed over 24 hours0.10.21.51.20.40.30.30.30.50.30.0-0.00.1-0.30.10.1-0.50.1
Number of responses in last shaping day0.30.31.60.70.50.20.30.50.60.1-0.5-1.30.60.1-0.6-0.50.3-0.5