Aldh1a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Aldh1a2	0.64	0.49	0.0e+00	0.41	0.45	0.44	0.44	6.6e-41	7.2e-46	2.4e-45	1.6e-45
2	OFC	gene expression	Aldh1a2	0.18	0.15	3.2e-03	0.07	0.07	0.06	0.06	1.0e-02	9.0e-03	2.0e-02	1.3e-02
3	IC	gene expression	Aldh1a2	0.18	0.11	7.8e-08	0.16	0.15	0.16	0.15	4.3e-07	7.3e-07	2.5e-07	6.0e-07
4	PL	gene expression	Aldh1a2	0.1	0.06	1.0e-14	0.12	0.14	0.13	0.13	3.7e-13	7.5e-15	7.5e-14	3.6e-14
5	NAcc	gene expression	Aldh1a2	0.04	0.03	3.9e-07	0.04	0.03	0.03	0.03	4.7e-06	7.1e-06	1.6e-05	1.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.3	0.5	0.6	0.7	0.8	-0.7	0.8	-0.7
Area under the delay curve	0.0	0.0	0.1	0.1	0.2	-0.1	0.2	-0.0
BMI with tail	6.3	22.1	23.4	-4.8	-4.8	4.8	-4.6	4.5
BMI without tail	1.5	7.8	8.8	-3.0	-2.9	2.7	-2.8	2.5
Body weight	4.3	18.7	21.5	-4.6	-4.4	4.3	-4.3	4.0
Weight adjusted by age	2.7	8.0	8.4	-2.8	-2.8	2.9	-2.8	2.9
Bone surface	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.4	0.4
Bone volume	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.1	0.1
Breakpoint value in progressive ratio session	0.4	0.7	0.9	-1.0	-0.9	0.8	-0.9	0.7
Number of licking bursts	0.6	1.9	2.0	1.4	1.4	-1.4	1.3	-1.4
Context. condit. distance diff. score	1.0	1.2	1.3	1.1	1.1	-1.0	1.2	-1.0
Locomotion velocity, session 1	1.6	1.8	2.0	-1.3	-1.4	1.3	-1.4	1.4
Locomotion distance, session 1	0.2	0.3	0.4	0.5	0.5	-0.6	0.5	-0.6
Locomotion velocity, session 2	0.2	0.2	0.2	-0.4	-0.5	0.5	-0.5	0.5
Locomotion distance, session 2	0.2	0.2	0.3	-0.5	-0.5	0.4	-0.5	0.4
Locomotion velocity, session 3	0.0	0.0	0.0	0.2	0.1	-0.2	0.0	-0.1
Locomotion distance, session 3	2.1	2.4	2.6	1.5	1.5	-1.6	1.5	-1.6
Stereotopy head waving bouts, day 3	0.6	0.7	0.7	-0.8	-0.8	0.8	-0.8	0.8
Stereotopy head waving duration, day 3	0.7	0.9	0.9	-0.9	-0.9	0.9	-1.0	1.0
Locomotion velocity, session 7	1.8	2.0	2.1	1.4	1.4	-1.4	1.4	-1.4
Locomotion distance, session 7	1.7	2.2	2.3	1.5	1.5	-1.5	1.4	-1.5
Stereotopy head waving bouts, day 7	1.0	1.2	1.3	-1.1	-1.1	1.1	-1.1	1.1
Stereotopy head waving duration, day 7	0.7	0.9	1.0	-0.9	-0.9	0.9	-1.0	1.0
Locomotion velocity, session 8	0.4	0.5	0.6	-0.7	-0.7	0.7	-0.7	0.7
Locomotion distance, session 8	0.5	0.8	0.8	0.9	0.9	-0.9	0.9	-0.9
Degree of sensitization distance	0.1	0.1	0.2	0.4	0.4	-0.3	0.3	-0.3
Degree of sensitization stereotypy	0.6	0.7	0.7	-0.8	-0.8	0.8	-0.8	0.8
Conditioned locomotion	0.1	0.1	0.1	0.3	0.3	-0.2	0.4	-0.2
Cocaine response after cond. corrected	2.4	3.5	3.8	-1.9	-2.0	1.8	-1.9	1.8
Cocaine response after cond. not corrected	1.3	2.0	2.2	-1.5	-1.5	1.3	-1.4	1.3
Cocaine response before conditioning	1.0	1.2	1.2	1.0	1.1	-1.0	1.1	-1.1
Saline control response	0.1	0.1	0.2	0.4	0.3	-0.4	0.3	-0.4
Bone: connectivity density	0.7	1.1	1.1	1.0	1.0	-1.0	1.0	-1.1
Bone: cortical apparent density	1.0	1.6	1.8	1.2	1.2	-1.3	1.2	-1.3
Bone: cortical area	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	-0.3
Bone: cortical porosity	1.3	1.4	1.5	1.1	1.2	-1.2	1.2	-1.2
Bone: cortical porosity	1.6	1.8	2.0	1.2	1.3	-1.3	1.4	-1.4
Bone: cortical thickness	1.6	2.7	2.8	1.7	1.6	-1.7	1.7	-1.7
Bone: cortical thickness	0.6	0.7	0.8	0.8	0.8	-0.9	0.8	-0.9
Bone: cortical tissue density	0.9	1.5	1.7	1.2	1.2	-1.3	1.1	-1.3
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.0	0.1	-0.1	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	0.6	0.7	-0.7	0.8	-0.8
Condit. Reinf. active responses	0.3	0.4	0.5	-0.7	-0.6	0.6	-0.5	0.6
Condit. Reinf. inactive responses	0.9	1.2	1.3	-1.0	-1.1	1.1	-1.1	1.1
Incentive salience index mean	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.0
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. active minus inactive responses	2.5	3.8	4.1	-2.0	-2.0	2.0	-1.9	1.9
Condit. Reinf. active-inactive response ratio	0.7	1.1	1.2	-1.1	-1.1	1.1	-1.0	1.1
Condit. Reinf. active responses	1.6	2.3	2.7	-1.6	-1.6	1.5	-1.4	1.4
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.2	-0.1	0.1	0.0	-0.0
Condit. Reinf. lever presses	0.5	0.7	0.8	0.8	0.8	-0.8	0.9	-0.9
Condit. Reinf. lever reinforcers received	1.0	1.4	1.7	-1.3	-1.2	1.2	-1.1	1.1
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.1	-0.1
Conditioned reinforcement - inactives	0.1	0.3	0.3	0.6	0.5	-0.5	0.5	-0.5
Conditioned locomotion	0.3	0.5	0.6	0.7	0.7	-0.7	0.8	-0.7
Patch foraging indifference point 0 sec	0.2	0.6	0.7	-0.8	-0.8	0.6	-0.8	0.7
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.2	-0.3
Delay disc. indifference point, 0s delay	0.5	0.5	0.6	0.7	0.7	-0.7	0.8	-0.7
Delay disc. indifference point, 16s delay	0.3	0.4	0.6	0.6	0.7	-0.6	0.8	-0.6
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	0.3	0.4	-0.5	0.5	-0.6
Delay disc. indifference point, 24s delay	0.2	0.3	0.4	0.7	0.6	-0.5	0.6	-0.5
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.5	0.6	-0.5	0.7	-0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.3	-0.3	0.4	-0.3	0.5
Indifference point function ln k	0.3	0.8	1.0	-0.8	-0.9	0.9	-1.0	1.0
Indifference point function log k	0.3	0.8	1.0	-0.8	-0.9	0.9	-1.0	1.0
Patch foraging total patch changes 0 sec	0.2	0.7	0.8	-0.9	-0.9	0.7	-0.9	0.8
Patch foraging total patch changes 12 sec	0.0	0.1	0.1	0.2	0.1	-0.2	0.3	-0.3
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.1	-0.0
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	-0.5	-0.6	0.4	-0.5	0.4
Patch foraging total patch changes 6 sec	0.2	0.4	0.5	-0.7	-0.7	0.6	-0.6	0.6
Patch foraging time to switch 0 sec	0.7	2.8	3.1	1.8	1.7	-1.6	1.7	-1.5
Patch foraging water rate 0 sec	1.0	3.9	4.2	-2.0	-2.0	2.0	-2.0	1.9
Patch foraging water rate 12 sec	1.8	7.3	8.4	-2.9	-2.8	2.6	-2.8	2.4
Patch foraging water rate 18 sec	0.4	0.8	0.9	-1.0	-0.9	0.8	-1.0	0.8
Patch foraging water rate 24 sec	0.3	0.4	0.7	-0.9	-0.7	0.4	-0.7	0.2
Patch foraging water rate 6 sec	1.4	2.0	2.4	-1.5	-1.5	1.4	-1.5	1.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	0.9	-0.9	-0.9	0.9	-0.9	1.0
Distance traveled before self-admin	0.0	0.0	0.1	0.3	0.2	-0.1	0.1	0.1
Distance traveled after self-admin	1.0	1.7	2.2	-1.2	-1.2	1.3	-1.4	1.5
Extensor digitorum longus weight	8.9	35.5	36.4	-6.0	-5.9	6.0	-5.9	5.9
Bone: elastic displacement	0.3	0.4	0.5	-0.7	-0.6	0.7	-0.6	0.7
Bone: elastic work	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.0	0.1
Bone: endosteal estimation	2.0	4.9	5.0	-2.2	-2.2	2.2	-2.2	2.2
Bone: endosteal perimeter	2.9	7.1	7.4	-2.7	-2.7	2.7	-2.6	2.6
Epididymis fat weight	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.2
Delta time in closed arm before/after self-admin	0.8	0.7	1.0	1.0	0.9	-0.7	0.9	-0.6
Delta time in open arm before/after self-admin	0.3	0.4	0.5	0.6	0.6	-0.7	0.6	-0.7
Diff in mean of infusions in LGA sessions	0.4	0.7	1.0	-1.0	-0.9	0.9	-0.7	0.6
Delay discount exponential model param	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.1	-0.0
Extinction: sum of active levers before priming	0.4	0.6	0.8	-0.8	-0.8	0.6	-0.9	0.6
Active lever presses in extinction session 6	0.6	0.6	0.6	-0.8	-0.7	0.8	-0.8	0.8
Bone: final force	0.2	0.4	0.5	-0.7	-0.7	0.6	-0.6	0.5
Bone: final moment	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.1	0.1
Food consumed during 24 hour testing period	0.5	1.0	1.2	-1.0	-1.0	0.9	-1.1	1.0
Glucose	0.7	1.2	1.4	-1.2	-1.2	1.0	-1.1	0.9
Heart weight	0.8	1.2	1.5	-1.1	-1.1	1.2	-1.0	1.1
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.3	0.2
Intermittent access intake day 1-15 change	0.1	0.6	1.2	1.1	0.9	-0.6	0.8	-0.3
Intermittent access intake escalation	0.1	0.4	0.8	0.9	0.7	-0.4	0.6	-0.2
Intermittent access intake escalation 2	0.0	0.0	0.1	0.1	0.0	0.1	-0.0	0.3
Intermitt. access day 1 inactive lever presses	0.2	2.9	4.1	2.0	1.9	-1.5	1.9	-1.2
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.4	0.0	-0.1	0.4	-0.2	0.7
Intermitt. access escalation Index	0.1	0.4	0.6	-0.5	-0.6	0.8	-0.6	0.8
Intermittent access day 1 total infusions	0.6	1.7	2.4	1.1	1.1	-1.5	1.2	-1.5
Intermittent access day 15 total infusions	0.9	2.3	2.4	1.5	1.5	-1.5	1.5	-1.5
Intermittent access terminal intake (last 3 days)	0.9	1.5	2.1	1.0	1.1	-1.3	1.2	-1.4
Intermittent access total infusions	0.7	0.9	1.3	0.7	0.8	-1.1	0.8	-1.2
Intermittent access day 1 locomotion	2.2	4.1	4.3	2.1	2.0	-2.0	2.0	-2.0
Intermittent access day 15 total locomotion	0.6	2.1	2.7	1.6	1.5	-1.3	1.5	-1.3
Intermittent access total locomotion	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	-0.4
Intermittent access standard deviation	0.0	0.2	0.4	0.6	0.5	-0.4	0.4	-0.3
Left kidney weight	0.9	7.6	8.2	-2.6	-2.7	2.9	-2.7	2.9
Right kidney weight	1.3	9.2	9.5	-3.1	-3.1	3.0	-3.1	2.9
Cocaine induced anxiety	0.1	0.2	0.3	0.4	0.5	-0.5	0.5	-0.6
Post-drug Anxiety	2.4	2.7	3.0	1.7	1.7	-1.6	1.6	-1.6
Baseline Anxiety	0.3	0.6	0.9	0.9	0.8	-0.8	0.7	-0.5
Tail length	0.0	0.1	0.3	-0.0	0.1	-0.4	0.1	-0.6
Length with tail	0.5	2.0	2.8	-1.7	-1.5	1.2	-1.5	1.1
Length without tail	2.0	10.7	12.0	-3.5	-3.4	3.2	-3.2	3.1
Times rat made contact with spout	0.3	0.3	0.4	0.6	0.6	-0.6	0.5	-0.5
Lifetime Intake	0.5	0.7	1.2	0.6	0.6	-1.0	0.7	-1.1
Liver weight, left	4.0	6.8	7.2	-2.6	-2.6	2.7	-2.6	2.6
Liver weight, right	1.1	1.8	2.0	-1.4	-1.4	1.3	-1.3	1.3
Locomotor activity	6.2	9.7	10.7	-3.3	-3.2	3.0	-3.2	3.0
Locomotor testing distance	2.7	6.7	7.1	-2.7	-2.6	2.5	-2.6	2.5
Locomotor testing rearing	0.9	3.3	3.8	-2.0	-1.9	1.7	-1.8	1.6
Locomotion in novel chamber	0.2	0.3	0.4	0.4	0.5	-0.7	0.5	-0.7
Locomotion in novel chamber post-restriction	0.2	0.6	0.8	0.9	0.9	-0.7	0.8	-0.5
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	0.4	0.4	-0.5	0.4	-0.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.3	-0.4	0.6	-0.6	0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.5	-0.4	0.3	-0.4	0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.3	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.4	-0.3	0.2	-0.3	0.2
Rest time, locomotor task time 1	0.0	0.1	0.2	0.1	0.1	-0.2	0.3	-0.4
Distance moved, locomotor task time 1	0.0	0.1	0.2	0.4	0.3	-0.2	0.3	0.0
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.4	0.4	-0.3	0.4	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.1	0.3
Bouts of movement, locomotor time 2	0.4	1.3	1.5	-1.2	-1.1	1.1	-1.1	1.0
Total resting periods, locomotor time 2	0.3	1.4	1.7	-1.3	-1.2	1.1	-1.2	1.1
Rest time, locomotor task time 2	0.2	0.3	0.4	0.6	0.6	-0.6	0.6	-0.6
Distance moved, locomotor task time 2	0.0	0.1	0.2	0.1	-0.0	0.2	-0.1	0.5
Vertical activity count, locomotor time 2	0.2	0.6	0.7	0.9	0.8	-0.8	0.8	-0.6
Light reinforcement 1	1.6	7.0	7.6	-2.7	-2.6	2.7	-2.5	2.8
Light reinforcement 2	0.1	0.1	0.2	0.3	0.3	-0.4	0.3	-0.4
Bone: marrow area	2.0	4.8	5.0	-2.1	-2.2	2.2	-2.2	2.2
Bone: maximum diameter	1.9	3.9	3.9	-2.0	-2.0	2.0	-2.0	1.9
Bone: maximum force	0.2	0.4	0.5	-0.7	-0.7	0.7	-0.6	0.6
Bone: maximum moment	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.2	0.2
Mean time between licks in bursts	0.0	0.2	0.4	0.6	0.6	-0.3	0.5	-0.3
Mean num. licks in bursts	0.3	0.9	1.0	-0.9	-0.9	1.0	-0.9	1.0
Cd content in liver	1.2	1.3	1.4	1.1	1.2	-1.1	1.2	-1.1
Co content in liver	1.0	1.2	1.4	1.0	1.1	-1.1	1.2	-1.1
Cu content in liver	0.0	0.0	0.0	-0.0	0.0	0.0	0.1	-0.1
Fe content in liver	0.3	0.3	0.4	-0.5	-0.6	0.5	-0.6	0.6
K content in liver	1.9	1.9	2.0	-1.4	-1.4	1.4	-1.3	1.3
Mg content in liver	1.5	1.6	1.7	-1.3	-1.3	1.3	-1.2	1.3
Mn content in liver	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1
Na content in liver	7.3	8.3	8.6	-2.9	-2.9	2.9	-2.9	2.8
Rb content in liver	0.8	0.9	1.0	-0.9	-0.9	0.9	-1.0	1.0
Se content in liver	0.0	0.1	0.1	0.2	0.2	-0.3	0.1	-0.3
Sr content in liver	0.1	0.1	0.1	0.2	0.2	-0.2	0.2	-0.3
Zn content in liver	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.0	0.1
Bone: minimum diameter	0.0	0.1	0.1	0.2	0.3	-0.2	0.3	-0.3
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1	0.1
Time in novel zone, hab. session 1	0.2	0.2	0.2	0.5	0.4	-0.4	0.4	-0.4
Total zone transitions, hab. session 1	0.2	0.3	0.4	0.7	0.6	-0.5	0.5	-0.5
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.2	0.2	-0.2	0.2	-0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.1	0.0
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.2	0.1	-0.1	0.1	-0.0
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.2	0.2	-0.3	0.3	-0.3
Total zone transitions, hab. session 2	0.4	0.5	0.6	-0.8	-0.7	0.7	-0.6	0.6
Total locomotion distance, hab. session 2	0.7	0.9	1.2	-1.1	-1.0	0.9	-0.9	0.9
Locomotion velocity, hab. session 2	0.4	0.5	0.7	-0.8	-0.7	0.7	-0.6	0.6
Novel to familiar place preference ratio	0.8	1.0	1.1	-1.0	-1.0	1.0	-1.0	1.0
Novelty place preference	0.8	1.0	1.1	-1.0	-1.0	1.0	-1.0	1.0
Time in novel zone, NPP test	1.0	1.2	1.3	-1.1	-1.1	1.1	-1.1	1.1
Total zone transitions, NPP test	0.3	0.4	0.4	-0.6	-0.6	0.6	-0.6	0.6
Total locomotion distance, NPP test	0.6	0.8	0.9	-0.9	-0.9	0.9	-0.9	0.8
Locomotion velocity, NPP test	0.2	0.3	0.3	-0.6	-0.6	0.5	-0.5	0.5
Intraocular pressure	0.0	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1
Delta distance traveled before/after self-admin	1.9	2.1	2.3	-1.5	-1.5	1.4	-1.5	1.4
Delta ambulatory time before/after self-admin	0.6	1.0	1.1	-1.0	-1.0	1.0	-1.1	1.0
Parametrial fat weight	1.2	2.7	3.4	1.5	1.5	-1.7	1.6	-1.8
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.5	0.4	-0.6	0.4	-0.5
Pavlov. Cond. magazine entry latency	0.6	0.8	1.2	0.7	0.9	-0.8	1.1	-0.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.0	0.1	0.0	0.2	-0.0
Pavlov. Cond. index score	0.4	0.5	0.7	0.6	0.7	-0.6	0.8	-0.7
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	0.4	-0.3	0.5	-0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.0	0.2
Pavlov. Cond. magazine entry number	1.0	1.2	1.7	-0.9	-1.1	1.0	-1.3	1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.3	-0.4	0.3	-0.4	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.4	0.5	-0.4	0.6	-0.4
Pavlov. Cond. response bias	0.3	0.4	0.6	0.4	0.6	-0.5	0.8	-0.6
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.5	-0.5	0.6	-0.6	0.7
Pavlov. Cond. magazine entry latency	3.1	4.3	4.5	2.0	2.1	-2.1	2.1	-2.1
Pavlov. Cond. change in total contacts	0.3	0.8	0.9	0.8	0.8	-0.8	0.9	-0.9
Pavlov. Cond. index score	0.8	1.3	1.4	1.1	1.1	-1.1	1.2	-1.2
Pavlov. Cond. latency score	0.5	0.8	0.8	0.8	0.8	-0.9	0.9	-0.9
Pavlov. Cond. lever contacts	0.2	0.3	0.4	0.5	0.5	-0.6	0.6	-0.7
Pavlov. Cond. magazine entry number	3.3	4.3	4.6	-2.0	-2.0	2.1	-2.1	2.1
Pavlov. Cond. intertrial magazine entries	0.7	1.4	1.5	-1.1	-1.2	1.2	-1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.4	1.6	1.1	1.2	-1.2	1.2	-1.3
Pavlov. Cond. response bias	1.5	2.0	2.4	1.3	1.4	-1.4	1.5	-1.5
Time in closed arm before self-admin	0.2	0.3	0.6	0.3	0.4	-0.6	0.4	-0.8
Time in closed arm after self-admin	0.4	0.5	0.5	0.7	0.7	-0.7	0.6	-0.6
Time in open arm before self-admin	0.9	1.1	1.9	-0.8	-0.9	1.2	-0.9	1.4
Time in open arm after self-admin	0.2	0.2	0.3	-0.3	-0.4	0.6	-0.4	0.5
Bone: periosteal estimation	0.9	2.2	2.2	-1.4	-1.5	1.5	-1.5	1.5
Bone: periosteal perimeter	1.5	2.9	3.0	-1.7	-1.7	1.7	-1.7	1.7
Bone: post-yield work	0.1	0.1	0.1	-0.4	-0.4	0.3	-0.4	0.4
Progressive ratio test 1 active lever presses	0.3	0.6	0.9	0.7	0.6	-0.9	0.7	-0.9
Progressive ratio test 1 breakpoint	0.4	0.7	0.9	0.7	0.7	-0.9	0.7	-1.0
Progressive ratio test 1 inactive lever presses	1.8	4.8	5.1	2.2	2.1	-2.3	2.2	-2.2
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.2	-0.2	0.0	-0.1	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.3	0.9	1.5	0.8	0.8	-1.0	0.9	-1.2
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	0.3
Incentive Sensitization - Breakpoint	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.2	0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.4	0.3
Progressive ratio	0.4	1.1	1.4	1.1	1.2	-0.9	1.1	-0.8
Food seeking constrained by brief footshock	0.5	0.6	0.9	-0.5	-0.7	0.8	-0.8	0.9
Seeking ratio, punishment vs. effort	2.6	5.8	6.2	-2.4	-2.5	2.3	-2.5	2.3
Retroperitoneal fat weight	0.1	0.4	0.8	0.5	0.5	-0.8	0.5	-0.9
Reaction time number correct	0.6	2.2	2.7	-1.6	-1.5	1.4	-1.6	1.3
Reaction time mean minus median	0.0	0.2	0.3	0.4	0.3	-0.5	0.4	-0.5
Reaction time mean minus median AUC	0.1	0.8	1.2	0.8	0.8	-1.0	0.8	-1.1
Reaction time num false alarms	0.3	0.6	0.7	0.8	0.8	-0.8	0.7	-0.7
Reaction time num false alarms AUC	0.1	0.2	0.3	0.5	0.4	-0.4	0.3	-0.3
Reaction time trials correct on left	0.6	2.2	2.7	-1.6	-1.5	1.4	-1.6	1.3
Reaction time trials on left	0.7	2.4	3.0	-1.7	-1.6	1.5	-1.6	1.3
Reaction time mean	1.6	3.5	3.9	1.8	1.8	-2.0	1.8	-2.0
Reaction time mean AUC	1.1	2.6	3.0	1.5	1.5	-1.7	1.5	-1.7
Median of all reaction times	3.6	5.6	6.0	2.3	2.3	-2.4	2.3	-2.4
Reaction time omissions	0.2	0.3	0.3	-0.4	-0.5	0.5	-0.5	0.5
Reaction time false alarm rate	1.1	1.5	2.0	1.4	1.3	-1.2	1.2	-1.0
Reaction time premature initiation rate	1.1	1.8	2.2	-1.5	-1.4	1.3	-1.3	1.1
Reaction time premature initiations	1.1	3.3	4.1	-2.0	-1.9	1.7	-1.8	1.5
Std. dev. reaction times	0.4	1.4	1.7	1.2	1.1	-1.3	1.1	-1.3
Reaction time trials completed	0.7	2.4	3.0	-1.7	-1.6	1.5	-1.6	1.3
Reaction time trials AUC	0.6	2.0	2.4	-1.6	-1.4	1.3	-1.5	1.2
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.3	0.1	0.1	0.1	0.3
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.3	-0.3	0.4	-0.4	0.5
Latency to leave start box in cocaine runway	1.5	2.0	2.5	-1.2	-1.4	1.5	-1.4	1.6
Latency to leave start box in cocaine runway, F	0.5	0.6	0.9	-0.6	-0.7	0.9	-0.8	1.0
Latency to leave start box in cocaine runway, M	4.7	4.5	4.7	-2.1	-2.1	2.1	-2.1	2.2
Std. dev. time between licks in bursts	0.5	0.9	1.1	-0.9	-0.9	1.1	-0.8	1.0
Total sessions with >9 infusions	0.6	0.7	1.4	0.6	0.6	-1.1	0.6	-1.2
Short access day 1 total inactive lever presses	0.4	0.8	1.2	1.1	1.0	-0.8	0.9	-0.8
Short access day 10 total inactive lever presses	0.2	1.3	2.2	1.5	1.3	-0.9	1.2	-0.7
Short access day 1 total infusions	0.2	0.3	0.5	0.7	0.6	-0.6	0.5	-0.5
Short access day 10 total infusions	1.5	2.5	3.7	1.3	1.4	-1.7	1.4	-1.9
Short access total infusions	1.0	1.4	2.3	0.9	1.0	-1.4	1.0	-1.5
Short access day 1 locomotion	0.1	0.1	0.2	0.4	0.3	-0.2	0.3	-0.2
Short access day 10 total locomotion	0.1	0.4	0.4	0.7	0.6	-0.6	0.5	-0.6
Short access total locomotion	0.6	0.9	1.1	0.9	0.9	-1.0	0.9	-1.1
One hour access (0.3 mA shock)	0.5	0.5	0.7	-0.8	-0.8	0.7	-0.8	0.5
Compulsive drug intake	1.2	1.8	2.2	-1.5	-1.5	1.2	-1.5	1.1
One hour access (shock baseline)	0.2	0.4	0.4	0.7	0.6	-0.6	0.6	-0.6
Social response proportion	0.1	0.1	0.2	0.5	0.4	-0.1	0.4	0.1
Social responses	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.0	-0.0
Social time	0.0	0.0	0.0	0.2	0.1	-0.1	-0.0	-0.0
Soleus weight	17.6	51.8	53.3	-7.3	-7.2	7.2	-7.2	7.2
Bone: stiffness	0.5	0.9	1.1	-0.9	-1.0	0.9	-1.0	0.9
Tibialis anterior weight	14.4	49.5	49.9	-7.0	-7.0	7.0	-7.0	7.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.2	0.3	-0.2	0.3	-0.2
Time to tail flick, vehicle, after self-admin	0.4	0.9	1.5	1.2	1.1	-0.7	0.9	-0.6
Time to tail flick, test, before self-admin	1.5	1.7	2.0	1.2	1.3	-1.3	1.4	-1.4
Time to tail flick, test, after self-admin	3.0	3.2	3.8	1.9	1.9	-1.8	1.7	-1.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.1	1.1	1.0	-0.7	0.8	-0.6
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.2	0.2
Tibia length	0.1	0.2	0.3	0.4	0.4	-0.4	0.5	-0.5
Ambulatory time before self-admin	0.1	0.2	0.3	0.5	0.5	-0.5	0.4	-0.6
Ambulatory time after self-admin	0.4	0.6	0.7	-0.7	-0.7	0.7	-0.9	0.7
Bone: tissue strength	1.4	1.4	1.5	1.2	1.2	-1.2	1.2	-1.1
Total heroin consumption	1.2	1.5	1.7	-1.2	-1.2	1.2	-1.2	1.3
Bone: trabecular number	0.9	1.6	1.7	1.3	1.3	-1.2	1.3	-1.3
Bone: trabecular spacing	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	0.1
Bone: trabecular thickness	0.3	0.5	0.5	0.7	0.7	-0.7	0.7	-0.7
Bone: trabecular tissue density	4.0	7.1	7.3	-2.6	-2.7	2.7	-2.7	2.7
Water consumed over 24 hours	0.2	0.4	0.5	0.6	0.6	-0.7	0.6	-0.7
Number of responses in last shaping day	0.1	0.1	0.3	0.5	0.4	-0.2	0.4	-0.3