Hub : Genes

Aldh1a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Aldh1a2	0.06	0.04	4.3e-08	0.06	0.06	0.06	0.06	9.7e-08	5.9e-08	3.0e-07	1.7e-07
2	PL	gene expression	Aldh1a2	0.11	0.07	9.6e-14	0.12	0.12	0.12	0.12	1.6e-13	1.7e-13	5.3e-13	1.8e-13
3	Adipose	gene expression	Aldh1a2	0.02	0.02	5.3e-03	0.01	0.01	0	0.01	8.8e-03	1.2e-02	7.5e-02	3.8e-02
4	Brain	gene expression	Aldh1a2	0.51	0.26	0.0e+00	0.46	0.46	0.46	0.46	8.0e-48	2.6e-47	9.8e-47	3.7e-47
5	OFC	gene expression	Aldh1a2	0.18	0.14	5.4e-03	0.08	0.06	0.04	0.06	6.7e-03	1.9e-02	3.9e-02	1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.4	0.7	0.8	0.8	-0.7	-0.8	-0.9	-0.9
Area under the delay curve	0.1	0.1	0.2	0.2	-0.1	-0.3	-0.4	-0.4
BMI with tail	4.7	15.1	17.4	-3.9	3.9	4.2	3.7	3.7
BMI without tail	2.1	4.3	5.2	-2.3	2.1	2.2	1.9	1.9
Body weight	4.0	16.7	18.0	-4.2	3.9	4.2	4.0	4.0
Weight adjusted by age	6.9	7.8	8.0	-2.8	2.8	2.8	2.8	2.8
Bone surface	0.1	0.2	0.3	-0.4	0.5	0.4	0.3	0.3
Bone volume	0.0	0.0	0.0	-0.1	0.2	0.1	-0.0	-0.0
Breakpoint value in progressive ratio session	0.3	0.3	0.4	-0.6	0.2	0.6	0.6	0.6
Number of licking bursts	1.7	2.0	2.3	1.4	-1.4	-1.3	-1.5	-1.5
Context. condit. distance diff. score	0.8	1.0	1.3	1.1	-1.1	-1.0	-0.9	-0.9
Locomotion velocity, session 1	1.8	2.0	2.2	-1.5	1.4	1.4	1.4	1.4
Locomotion distance, session 1	0.2	0.3	0.4	0.4	-0.6	-0.5	-0.5	-0.5
Locomotion velocity, session 2	0.2	0.2	0.3	-0.5	0.5	0.4	0.4	0.4
Locomotion distance, session 2	0.1	0.2	0.3	-0.6	0.4	0.4	0.4	0.4
Locomotion velocity, session 3	0.0	0.0	0.0	0.0	-0.1	-0.1	0.0	0.0
Locomotion distance, session 3	2.1	2.3	2.7	1.5	-1.6	-1.6	-1.5	-1.5
Stereotopy head waving bouts, day 3	0.5	0.6	0.7	-0.8	0.9	0.8	0.6	0.6
Stereotopy head waving duration, day 3	0.7	0.8	1.0	-0.9	1.0	0.9	0.8	0.8
Locomotion velocity, session 7	1.7	1.8	2.2	1.4	-1.5	-1.4	-1.3	-1.3
Locomotion distance, session 7	1.6	2.0	2.1	1.4	-1.5	-1.5	-1.4	-1.4
Stereotopy head waving bouts, day 7	0.8	0.9	1.1	-1.0	1.0	1.0	0.9	0.9
Stereotopy head waving duration, day 7	0.7	0.9	1.1	-1.0	1.0	1.0	0.8	0.8
Locomotion velocity, session 8	0.4	0.5	0.6	-0.7	0.6	0.7	0.8	0.8
Locomotion distance, session 8	0.4	0.6	0.8	0.8	-0.9	-0.9	-0.7	-0.7
Degree of sensitization distance	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.3	-0.3
Degree of sensitization stereotypy	0.6	0.7	0.7	-0.8	0.9	0.8	0.8	0.8
Conditioned locomotion	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.1	-0.1
Cocaine response after cond. corrected	2.9	3.3	3.7	-1.9	1.7	1.9	1.8	1.8
Cocaine response after cond. not corrected	1.6	1.8	2.1	-1.4	1.1	1.4	1.3	1.3
Cocaine response before conditioning	1.0	1.3	1.5	1.2	-1.2	-1.2	-1.0	-1.0
Saline control response	0.2	0.3	0.4	0.5	-0.5	-0.6	-0.6	-0.6
Bone: connectivity density	0.8	1.3	1.4	1.1	-1.1	-1.2	-1.2	-1.2
Bone: cortical apparent density	0.6	0.8	0.9	0.8	-0.9	-0.8	-1.0	-1.0
Bone: cortical area	0.0	0.0	0.1	0.0	-0.0	-0.1	0.2	0.2
Bone: cortical porosity	0.9	0.9	1.0	0.9	-1.0	-1.0	-1.0	-1.0
Bone: cortical porosity	1.8	1.9	2.0	1.3	-1.4	-1.4	-1.4	-1.4
Bone: cortical thickness	1.1	1.8	2.0	1.4	-1.3	-1.4	-1.3	-1.3
Bone: cortical thickness	0.6	0.7	1.0	0.8	-0.9	-1.0	-0.8	-0.8
Bone: cortical tissue density	0.6	0.8	0.9	0.8	-0.9	-0.8	-0.9	-0.9
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.1	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.7	0.8	-0.8	-0.8	-0.6	-0.6
Condit. Reinf. active responses	0.3	0.4	0.5	-0.6	0.4	0.6	0.7	0.7
Condit. Reinf. inactive responses	1.2	1.4	1.7	-1.2	1.0	1.1	1.3	1.3
Incentive salience index mean	0.0	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	-0.2	-0.1	0.2	0.2
Condit. Reinf. active minus inactive responses	2.4	3.0	3.3	-1.8	1.8	1.8	1.7	1.7
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.1	-1.0	1.0	1.0	0.8	0.8
Condit. Reinf. active responses	1.2	1.6	1.9	-1.4	1.3	1.3	1.2	1.2
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.1
Condit. Reinf. lever presses	0.5	0.7	0.8	0.8	-0.9	-0.9	-0.7	-0.7
Condit. Reinf. lever reinforcers received	0.6	0.9	1.0	-1.0	1.0	0.9	0.9	0.9
Conditioned reinforcement - actives	0.0	0.0	0.1	0.2	-0.2	-0.0	0.0	0.0
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.2	-0.4	-0.5	0.0	0.0
Conditioned locomotion	0.5	0.6	0.8	0.8	-0.7	-0.9	-0.7	-0.7
Patch foraging indifference point 0 sec	0.3	0.5	0.8	-0.7	0.5	0.5	0.9	0.9
Patch foraging indifference point AUC	0.1	0.1	0.1	0.0	-0.3	-0.3	-0.3	-0.3
Delay disc. indifference point, 0s delay	0.5	0.6	0.7	0.6	-0.6	-0.8	-0.9	-0.9
Delay disc. indifference point, 16s delay	0.5	0.5	0.6	0.7	-0.7	-0.7	-0.8	-0.8
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	0.4	-0.6	-0.8	-0.5	-0.5
Delay disc. indifference point, 24s delay	0.4	0.3	0.4	0.6	-0.5	-0.5	-0.6	-0.6
Delay disc. indifference point, 4s delay	0.5	0.5	0.7	0.6	-0.5	-0.8	-0.8	-0.8
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.2	0.5	0.1	-0.0	-0.0
Indifference point function ln k	0.6	0.9	1.0	-0.8	1.0	0.8	1.0	1.0
Indifference point function log k	0.6	0.9	1.0	-0.8	1.0	0.8	1.0	1.0
Patch foraging total patch changes 0 sec	0.5	0.8	1.3	-0.9	0.6	0.7	1.1	1.1
Patch foraging total patch changes 12 sec	0.0	0.1	0.1	0.2	-0.4	-0.3	0.1	0.1
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.3	-0.1	0.0	0.1	0.1
Patch foraging total patch changes 24 sec	0.3	0.3	0.6	-0.5	0.2	0.3	0.8	0.8
Patch foraging total patch changes 6 sec	0.3	0.4	0.5	-0.7	0.3	0.5	0.7	0.7
Patch foraging time to switch 0 sec	1.6	2.5	2.6	1.6	-1.6	-1.4	-1.6	-1.6
Patch foraging water rate 0 sec	2.4	3.9	4.2	-2.1	2.0	1.7	2.0	2.0
Patch foraging water rate 12 sec	4.1	6.3	7.3	-2.7	2.3	2.4	2.5	2.5
Patch foraging water rate 18 sec	0.6	0.9	1.0	-0.9	0.8	0.8	1.0	1.0
Patch foraging water rate 24 sec	0.2	0.2	0.4	-0.6	0.2	0.3	0.5	0.5
Patch foraging water rate 6 sec	1.2	1.8	2.2	-1.4	1.2	1.1	1.5	1.5
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.1	-0.9	1.1	0.8	1.0	1.0
Distance traveled before self-admin	0.0	0.0	0.1	0.1	0.3	0.1	0.1	0.1
Distance traveled after self-admin	2.0	2.2	2.8	-1.4	1.7	1.5	1.4	1.4
Extensor digitorum longus weight	8.0	31.5	33.9	-5.6	5.7	5.8	5.5	5.5
Bone: elastic displacement	0.2	0.3	0.4	-0.6	0.6	0.6	0.4	0.4
Bone: elastic work	0.0	0.0	0.0	-0.1	0.1	0.0	-0.1	-0.1
Bone: endosteal estimation	2.5	5.4	6.1	-2.2	2.2	2.2	2.5	2.5
Bone: endosteal perimeter	3.8	7.8	8.8	-2.7	2.7	2.6	3.0	3.0
Epididymis fat weight	0.0	0.1	0.1	-0.3	0.4	0.3	-0.3	-0.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.2	0.2	-0.1	-0.3	-0.3
Delta time in open arm before/after self-admin	1.3	1.3	1.6	1.0	-1.3	-1.1	-1.2	-1.2
Diff in mean of infusions in LGA sessions	0.4	0.4	0.5	-0.7	0.4	0.6	0.7	0.7
Delay discount exponential model param	0.0	0.0	0.1	-0.1	-0.0	0.2	0.3	0.3
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.1	-0.5	-0.0	-0.1	-0.1
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2
Bone: final force	0.6	0.9	1.2	-0.9	0.9	0.8	1.1	1.1
Bone: final moment	0.2	0.3	0.5	-0.5	0.5	0.4	0.7	0.7
Food consumed during 24 hour testing period	0.7	0.8	1.1	-1.0	1.1	0.8	0.8	0.8
Glucose	0.5	0.7	1.0	-1.0	0.9	0.9	0.8	0.8
Heart weight	0.3	0.5	0.5	-0.6	0.7	0.7	0.7	0.7
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.3	0.2	0.4	0.4	0.4
Intermittent access intake day 1-15 change	0.8	0.8	1.2	1.0	-0.8	-1.1	-0.7	-0.7
Intermittent access intake escalation	1.2	1.1	1.5	1.2	-1.0	-1.2	-1.0	-1.0
Intermittent access intake escalation 2	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.1	-0.1
Intermitt. access day 1 inactive lever presses	1.3	1.4	1.7	1.3	-0.9	-1.3	-1.2	-1.2
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	0.6	-0.2	-0.2	-0.6	-0.6
Intermitt. access escalation Index	1.2	1.1	2.0	-1.0	1.4	1.1	0.8	0.8
Intermittent access day 1 total infusions	0.5	0.6	1.0	0.8	-1.0	-0.7	-0.7	-0.7
Intermittent access day 15 total infusions	1.7	1.9	2.5	1.5	-1.6	-1.3	-1.2	-1.2
Intermittent access terminal intake (last 3 days)	1.3	1.4	2.3	1.1	-1.5	-1.1	-1.1	-1.1
Intermittent access total infusions	0.6	0.7	1.3	0.8	-1.1	-0.8	-0.6	-0.6
Intermittent access day 1 locomotion	2.1	2.2	2.7	1.6	-1.5	-1.4	-1.4	-1.4
Intermittent access day 15 total locomotion	1.2	1.3	1.9	1.4	-1.2	-1.1	-1.1	-1.1
Intermittent access total locomotion	0.0	0.0	0.1	0.3	-0.3	-0.1	-0.1	-0.1
Intermittent access standard deviation	0.8	0.8	1.5	1.2	-1.0	-0.9	-0.6	-0.6
Left kidney weight	2.3	6.4	7.4	-2.5	2.7	2.7	2.4	2.4
Right kidney weight	2.1	6.0	6.4	-2.5	2.3	2.4	2.5	2.5
Cocaine induced anxiety	0.4	0.4	0.5	0.5	-0.7	-0.7	-0.7	-0.7
Post-drug Anxiety	2.1	2.3	2.8	1.4	-1.5	-1.7	-1.5	-1.5
Baseline Anxiety	0.4	0.4	0.6	0.6	-0.4	-0.8	-0.6	-0.6
Tail length	0.1	0.2	0.4	-0.6	0.2	0.3	0.4	0.4
Length with tail	0.9	3.5	3.9	-1.9	1.6	1.8	2.0	2.0
Length without tail	2.3	4.9	5.6	-2.0	2.1	2.3	2.4	2.4
Times rat made contact with spout	0.3	0.3	0.5	0.5	-0.4	-0.4	-0.7	-0.7
Lifetime Intake	0.7	0.8	1.5	0.9	-1.2	-0.9	-0.6	-0.6
Liver weight, left	0.9	1.5	1.9	-1.3	1.4	1.2	1.1	1.1
Liver weight, right	2.1	3.5	3.7	-1.9	1.9	1.7	1.9	1.9
Locomotor activity	6.2	9.8	10.6	-3.1	2.9	3.2	3.2	3.2
Locomotor testing distance	2.9	4.9	5.3	-2.3	2.3	2.2	2.2	2.2
Locomotor testing rearing	1.4	2.2	2.6	-1.6	1.5	1.4	1.4	1.4
Locomotion in novel chamber	0.6	0.8	1.2	1.0	-1.1	-1.0	-0.5	-0.5
Locomotion in novel chamber post-restriction	0.2	0.3	0.4	0.6	-0.4	-0.6	-0.6	-0.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.1	-0.1
Change in fecal boli incidents, locomotor task	0.6	0.6	0.7	-0.7	0.9	0.8	0.7	0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	0.3	0.3	0.4	0.4
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	0.3	0.4	0.4
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.4	0.2	0.2	0.3	0.3
Rest time, locomotor task time 1	0.1	0.2	0.2	0.1	-0.5	-0.3	-0.5	-0.5
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.2	0.0	-0.2	-0.4	-0.4
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.2	0.4	0.2	0.0	0.0
Bouts of movement, locomotor time 2	0.8	0.9	1.6	-1.1	1.2	0.6	0.8	0.8
Total resting periods, locomotor time 2	0.9	0.9	1.5	-1.2	1.2	0.6	0.8	0.8
Rest time, locomotor task time 2	0.6	0.7	0.9	0.6	-0.7	-0.9	-1.0	-1.0
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.1	0.4	0.4	0.2	0.2
Vertical activity count, locomotor time 2	0.3	0.4	0.6	0.8	-0.6	-0.6	-0.5	-0.5
Light reinforcement 1	3.3	6.0	7.0	-2.4	2.6	2.2	2.5	2.5
Light reinforcement 2	0.1	0.2	0.3	0.4	-0.5	-0.6	-0.3	-0.3
Bone: marrow area	2.5	5.5	6.2	-2.2	2.3	2.2	2.5	2.5
Bone: maximum diameter	2.3	4.3	4.8	-2.0	2.0	1.9	2.2	2.2
Bone: maximum force	0.6	1.1	1.1	-1.0	1.0	1.0	1.1	1.1
Bone: maximum moment	0.2	0.4	0.5	-0.6	0.7	0.6	0.7	0.7
Mean time between licks in bursts	0.1	0.2	0.3	0.5	-0.3	-0.4	-0.5	-0.5
Mean num. licks in bursts	0.8	1.0	1.1	-0.9	1.1	1.0	1.0	1.0
Cd content in liver	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.3	-0.3
Co content in liver	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.1
Cu content in liver	0.3	0.3	0.3	-0.6	0.6	0.6	0.5	0.5
Fe content in liver	0.6	0.7	0.9	0.7	-0.8	-0.7	-1.0	-1.0
K content in liver	2.0	2.0	2.1	-1.4	1.4	1.4	1.4	1.4
Mg content in liver	3.9	4.0	4.1	-2.0	2.0	2.0	2.0	2.0
Mn content in liver	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.1
Na content in liver	2.4	2.5	2.9	-1.7	1.5	1.6	1.5	1.5
Rb content in liver	1.8	2.2	2.5	-1.5	1.5	1.6	1.4	1.4
Se content in liver	0.4	0.5	0.6	0.7	-0.8	-0.7	-0.7	-0.7
Sr content in liver	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1
Zn content in liver	0.3	0.4	0.5	0.7	-0.7	-0.7	-0.5	-0.5
Bone: minimum diameter	0.0	0.1	0.2	0.1	-0.1	-0.1	0.4	0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.1	0.2	0.2	-0.3	-0.3
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.1	-0.1
Total zone transitions, hab. session 1	0.2	0.3	0.3	0.6	-0.5	-0.6	-0.6	-0.6
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.1	0.1	0.0	0.2	0.2
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.1	-0.0	0.0	-0.3	-0.3
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	-0.3	-0.4	-0.1	-0.1
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.6	0.5	0.6	0.5	0.5
Total locomotion distance, hab. session 2	0.7	0.9	0.9	-1.0	0.9	0.9	1.0	1.0
Locomotion velocity, hab. session 2	0.3	0.4	0.5	-0.7	0.6	0.6	0.7	0.7
Novel to familiar place preference ratio	1.1	1.2	1.4	-1.0	1.0	1.0	1.2	1.2
Novelty place preference	1.1	1.2	1.4	-1.0	1.0	1.0	1.2	1.2
Time in novel zone, NPP test	1.4	1.4	1.6	-1.1	1.1	1.1	1.3	1.3
Total zone transitions, NPP test	0.2	0.2	0.4	-0.6	0.5	0.5	0.4	0.4
Total locomotion distance, NPP test	0.6	0.8	0.9	-0.9	0.8	0.8	1.0	1.0
Locomotion velocity, NPP test	0.2	0.3	0.4	-0.6	0.5	0.5	0.6	0.6
Intraocular pressure	0.0	0.0	0.1	-0.1	0.1	0.4	0.1	0.1
Delta distance traveled before/after self-admin	2.0	2.2	2.3	-1.5	1.5	1.5	1.4	1.4
Delta ambulatory time before/after self-admin	0.9	1.0	1.1	-1.1	1.1	1.0	0.9	0.9
Parametrial fat weight	0.0	0.0	0.1	-0.2	-0.3	-0.0	0.2	0.2
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	-0.3
Pavlov. Cond. magazine entry latency	0.7	0.9	1.2	1.0	-1.1	-0.9	-0.9	-0.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.0	-0.0
Pavlov. Cond. index score	0.5	0.6	0.7	0.8	-0.8	-0.7	-0.8	-0.8
Pavlov. Cond. latency score	0.2	0.2	0.2	0.4	-0.5	-0.4	-0.5	-0.5
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.0	-0.0	0.0	0.1	0.1
Pavlov. Cond. magazine entry number	1.3	1.6	2.0	-1.3	1.4	1.2	1.2	1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	-0.4	0.3	0.3	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.4	0.6	-0.6	-0.5	-0.6	-0.6
Pavlov. Cond. response bias	0.4	0.5	0.7	0.8	-0.8	-0.7	-0.5	-0.5
Pavlov. Cond. lever latency	0.5	0.7	0.9	-0.8	0.9	0.9	0.8	0.8
Pavlov. Cond. magazine entry latency	3.4	4.0	4.3	2.0	-2.1	-2.0	-1.9	-1.9
Pavlov. Cond. change in total contacts	0.5	0.7	0.8	0.8	-0.9	-0.9	-0.8	-0.8
Pavlov. Cond. index score	0.9	1.2	1.3	1.1	-1.1	-1.2	-1.0	-1.0
Pavlov. Cond. latency score	0.6	0.7	0.9	0.8	-0.9	-0.9	-0.8	-0.8
Pavlov. Cond. lever contacts	0.2	0.3	0.5	0.5	-0.6	-0.7	-0.5	-0.5
Pavlov. Cond. magazine entry number	3.0	3.7	4.2	-1.9	2.0	1.9	1.8	1.8
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.9	-0.9	1.0	0.8	0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.6	1.1	-1.3	-1.3	-1.2	-1.2
Pavlov. Cond. response bias	1.2	1.6	1.9	1.2	-1.4	-1.4	-1.2	-1.2
Time in closed arm before self-admin	0.2	0.3	1.1	0.5	-1.0	-0.0	-0.1	-0.1
Time in closed arm after self-admin	0.1	0.1	0.1	0.1	-0.1	0.2	0.3	0.3
Time in open arm before self-admin	1.0	1.1	2.6	-1.0	1.6	1.0	0.7	0.7
Time in open arm after self-admin	0.2	0.2	0.4	0.1	-0.1	-0.3	-0.6	-0.6
Bone: periosteal estimation	1.6	3.2	4.0	-1.7	1.7	1.6	2.0	2.0
Bone: periosteal perimeter	2.3	3.8	4.6	-1.8	1.8	1.7	2.1	2.1
Bone: post-yield work	0.1	0.2	0.2	-0.3	0.3	0.4	0.4	0.4
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	-0.2	0.1	0.1	0.1
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	0.2	-0.5	-0.4	-0.4	-0.4
Progressive ratio test 1 inactive lever presses	1.6	1.8	2.4	1.2	-1.2	-1.6	-1.3	-1.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.2	-0.1	0.3	0.4	0.4
Progressive ratio test 2 breakpoint	0.2	0.3	0.4	-0.5	0.2	0.5	0.6	0.6
Progressive ratio test 2 inactive lever presses	1.2	1.4	1.8	1.1	-1.3	-1.3	-1.1	-1.1
Incentive Sensitization - Responses	0.2	0.2	0.3	-0.5	0.4	0.6	0.5	0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.3	0.3	0.4	0.3	0.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1
Progressive ratio	0.7	0.8	1.1	1.0	-0.6	-0.7	-1.0	-1.0
Food seeking constrained by brief footshock	1.0	1.3	1.9	-1.1	1.2	1.4	0.9	0.9
Seeking ratio, punishment vs. effort	4.3	5.2	5.8	-2.4	2.2	2.2	2.3	2.3
Retroperitoneal fat weight	0.0	0.1	0.2	-0.4	0.5	0.1	-0.1	-0.1
Reaction time number correct	1.5	2.1	2.6	-1.6	1.4	1.5	1.4	1.4
Reaction time mean minus median	0.2	0.3	0.4	0.5	-0.6	-0.6	-0.5	-0.5
Reaction time mean minus median AUC	0.8	1.0	1.3	0.9	-1.1	-1.1	-0.9	-0.9
Reaction time num false alarms	0.4	0.5	0.6	0.7	-0.8	-0.7	-0.7	-0.7
Reaction time num false alarms AUC	0.0	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.2
Reaction time trials correct on left	1.5	2.1	2.6	-1.6	1.4	1.5	1.4	1.4
Reaction time trials on left	1.6	2.3	2.9	-1.7	1.5	1.5	1.5	1.5
Reaction time mean	2.7	3.7	4.1	1.8	-2.0	-1.9	-1.9	-1.9
Reaction time mean AUC	2.0	2.7	3.2	1.6	-1.8	-1.6	-1.6	-1.6
Median of all reaction times	3.6	5.0	5.2	2.2	-2.3	-2.2	-2.3	-2.3
Reaction time omissions	0.3	0.4	0.6	-0.7	0.7	0.8	0.4	0.4
Reaction time false alarm rate	0.9	1.3	1.5	1.2	-1.1	-1.1	-1.1	-1.1
Reaction time premature initiation rate	1.0	1.3	1.9	-1.4	1.2	1.2	0.9	0.9
Reaction time premature initiations	2.0	2.8	3.9	-2.0	1.7	1.7	1.5	1.5
Std. dev. reaction times	1.1	1.5	1.7	1.1	-1.3	-1.2	-1.3	-1.3
Reaction time trials completed	1.6	2.3	2.9	-1.7	1.5	1.5	1.5	1.5
Reaction time trials AUC	1.3	1.8	2.3	-1.5	1.3	1.4	1.3	1.3
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.2	0.3	0.2	0.5	0.5
Run reversals in cocaine runway, males	0.3	0.3	0.4	-0.3	0.4	0.4	0.6	0.6
Latency to leave start box in cocaine runway	1.9	2.1	2.8	-1.3	1.7	1.5	1.3	1.3
Latency to leave start box in cocaine runway, F	0.3	0.4	0.9	-0.5	1.0	0.7	0.3	0.3
Latency to leave start box in cocaine runway, M	3.3	3.2	3.7	-1.7	1.7	1.7	1.9	1.9
Std. dev. time between licks in bursts	1.0	1.2	1.5	-0.8	1.0	1.1	1.2	1.2
Total sessions with >9 infusions	0.2	0.3	0.4	0.3	-0.6	-0.7	-0.4	-0.4
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.1	0.1	-0.1	0.3	0.3
Short access day 10 total inactive lever presses	1.1	1.2	1.5	1.1	-0.6	-1.1	-1.2	-1.2
Short access day 1 total infusions	0.3	0.3	0.4	0.6	-0.6	-0.7	-0.4	-0.4
Short access day 10 total infusions	0.6	0.6	1.1	0.7	-1.0	-0.9	-0.6	-0.6
Short access total infusions	1.1	1.2	1.8	1.0	-1.3	-1.2	-1.0	-1.0
Short access day 1 locomotion	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.1	-0.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	0.3	0.1	0.2	0.2
Short access total locomotion	1.1	1.1	1.6	1.0	-1.0	-1.3	-1.0	-1.0
One hour access (0.3 mA shock)	0.2	0.2	0.4	-0.1	-0.0	0.6	0.6	0.6
Compulsive drug intake	0.7	0.8	0.9	-0.8	0.7	0.8	1.0	1.0
One hour access (shock baseline)	0.4	0.5	0.7	0.9	-0.8	-0.6	-0.5	-0.5
Social response proportion	0.0	0.0	0.1	0.3	0.2	0.1	-0.0	-0.0
Social responses	0.0	0.1	0.1	-0.2	0.2	0.2	0.2	0.2
Social time	0.0	0.0	0.0	-0.0	0.1	0.1	0.2	0.2
Soleus weight	17.2	50.3	50.8	-7.0	7.0	7.1	7.1	7.1
Bone: stiffness	1.3	2.1	2.6	-1.4	1.3	1.3	1.6	1.6
Tibialis anterior weight	13.2	45.2	46.5	-6.7	6.8	6.8	6.7	6.7
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	-0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.3	0.3	0.0	-0.3	-0.3
Time to tail flick, test, before self-admin	1.1	1.1	1.3	1.0	-1.1	-1.1	-1.0	-1.0
Time to tail flick, test, after self-admin	2.0	2.1	2.5	1.6	-1.3	-1.4	-1.4	-1.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	0.6	-0.4	-0.5	-0.5	-0.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1
Tibia length	0.1	0.2	0.2	0.5	-0.4	-0.4	-0.4	-0.4
Ambulatory time before self-admin	0.1	0.1	0.2	0.5	-0.3	-0.4	-0.2	-0.2
Ambulatory time after self-admin	0.9	1.0	1.0	-0.9	1.0	1.0	1.0	1.0
Bone: tissue strength	1.9	1.9	2.1	1.3	-1.3	-1.3	-1.5	-1.5
Total heroin consumption	1.6	1.8	2.0	-1.4	1.4	1.4	1.3	1.3
Bone: trabecular number	1.2	1.8	2.0	1.3	-1.2	-1.4	-1.4	-1.4
Bone: trabecular spacing	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.0
Bone: trabecular thickness	0.2	0.3	0.4	0.5	-0.4	-0.5	-0.6	-0.6
Bone: trabecular tissue density	5.7	8.0	9.0	-2.9	3.0	2.9	2.6	2.6
Water consumed over 24 hours	0.5	0.6	0.7	0.8	-0.7	-0.8	-0.8	-0.8
Number of responses in last shaping day	0.2	0.2	0.3	0.4	-0.5	-0.4	-0.6	-0.6