Hub : Genes

Spata31f1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Spata31f1	0.07	0.05	4.7e-07	0.06	0.05	0.06	0.06	1.1e-07	2.9e-06	1.0e-06	4.4e-07
2	Adipose	gene expression	Spata31f1	0.17	0.09	0.0e+00	0.08	0.13	0.13	0.14	3.0e-09	4.4e-14	2.7e-14	3.0e-15
3	Brain	gene expression	Spata31f1	0.09	0.06	1.1e-05	0.06	0.06	0.06	0.06	3.8e-06	8.0e-06	4.6e-06	1.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.4	0.6	1.3	1.2	-0.6	0.4
Area under the delay curve	0.5	0.5	0.6	-0.7	0.7	-0.8
BMI with tail	0.7	2.2	5.2	2.3	-0.9	0.8
BMI without tail	2.0	4.1	11.3	3.4	0.8	-0.7
Body weight	1.1	4.4	12.6	3.6	0.6	-0.5
Weight adjusted by age	1.1	1.2	2.1	0.2	1.5	-1.2
Bone surface	0.3	0.6	1.1	1.1	0.5	-0.5
Bone volume	0.2	0.3	1.0	1.0	-0.0	-0.1
Breakpoint value in progressive ratio session	1.9	2.1	3.2	-0.5	1.7	-1.8
Number of licking bursts	2.1	2.5	7.2	2.7	-0.1	0.5
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	-0.3	0.4
Locomotion velocity, session 1	7.6	8.2	11.7	1.1	3.4	-3.4
Locomotion distance, session 1	2.1	2.7	3.7	0.9	1.9	-1.9
Locomotion velocity, session 2	0.8	1.0	2.3	1.5	-0.5	0.6
Locomotion distance, session 2	2.0	2.8	4.3	2.1	1.4	-1.4
Locomotion velocity, session 3	1.5	1.8	2.7	0.4	1.6	-1.6
Locomotion distance, session 3	1.8	2.0	2.9	1.7	1.2	-1.2
Stereotopy head waving bouts, day 3	1.4	1.6	2.5	-0.1	1.6	-1.6
Stereotopy head waving duration, day 3	0.5	0.6	0.8	-0.5	0.9	-0.9
Locomotion velocity, session 7	0.0	0.0	0.1	-0.4	-0.0	0.1
Locomotion distance, session 7	0.2	0.3	0.3	0.6	0.5	-0.5
Stereotopy head waving bouts, day 7	1.2	1.3	3.0	1.7	0.7	-0.7
Stereotopy head waving duration, day 7	0.5	0.7	1.0	1.0	0.7	-0.7
Locomotion velocity, session 8	1.1	1.3	1.9	0.6	1.4	-1.3
Locomotion distance, session 8	0.9	1.3	1.6	0.9	1.3	-1.2
Degree of sensitization distance	0.6	0.6	1.2	-1.1	-0.5	0.5
Degree of sensitization stereotypy	0.5	0.6	1.6	1.3	0.2	-0.3
Conditioned locomotion	0.9	1.0	1.6	0.2	1.2	-1.3
Cocaine response after cond. corrected	2.1	2.4	3.4	-1.0	1.8	-1.7
Cocaine response after cond. not corrected	2.6	2.8	4.2	-0.8	2.1	-1.9
Cocaine response before conditioning	0.3	0.4	1.0	1.0	-0.2	0.1
Saline control response	1.7	2.3	2.5	1.4	1.6	-1.5
Bone: connectivity density	0.3	0.4	0.6	0.6	-0.8	0.6
Bone: cortical apparent density	1.8	2.3	3.4	-0.4	-1.9	1.9
Bone: cortical area	0.9	1.3	2.8	1.7	-0.7	0.8
Bone: cortical porosity	0.2	0.2	0.5	-0.7	-0.2	0.1
Bone: cortical porosity	0.0	0.0	0.0	-0.0	-0.1	-0.0
Bone: cortical thickness	1.0	1.6	2.2	0.7	-1.5	1.5
Bone: cortical thickness	0.5	0.6	0.8	-0.5	-0.9	0.8
Bone: cortical tissue density	1.6	2.1	3.0	-0.4	-1.7	1.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.7	-0.2	0.4
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	-1.0	-0.5	0.6
Condit. Reinf. active responses	1.0	1.2	3.3	1.8	-0.3	0.5
Condit. Reinf. inactive responses	1.2	1.5	3.5	1.9	-0.5	0.8
Incentive salience index mean	1.7	2.1	6.0	2.4	0.4	-0.2
Condit. Reinf. lever presses	5.2	6.9	16.5	4.1	1.6	-1.4
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	0.9	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	-0.3	0.5
Condit. Reinf. active responses	0.8	1.0	3.1	1.8	0.0	-0.2
Condit. Reinf. inactive responses	1.2	1.5	3.8	1.9	-0.8	0.4
Condit. Reinf. lever presses	1.1	1.5	1.8	1.3	-1.3	1.1
Condit. Reinf. lever reinforcers received	0.9	1.2	3.6	1.9	0.0	-0.1
Conditioned reinforcement - actives	0.3	0.3	0.7	0.9	-0.1	0.2
Conditioned reinforcement - inactives	0.2	0.2	0.5	0.7	0.3	-0.3
Conditioned locomotion	0.2	0.2	0.6	0.8	0.2	-0.2
Patch foraging indifference point 0 sec	3.5	5.7	8.3	0.8	2.9	-2.8
Patch foraging indifference point AUC	2.9	3.3	9.0	3.0	0.7	-0.7
Delay disc. indifference point, 0s delay	0.6	0.6	1.0	-1.0	0.6	-0.7
Delay disc. indifference point, 16s delay	1.5	1.5	2.2	-0.5	1.4	-1.5
Delay disc. indifference point, 2s delay	0.2	0.3	0.4	0.1	-0.7	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.5	-0.0	0.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.6	-0.0	-0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.2	0.1	-0.2
Indifference point function ln k	0.9	1.2	3.5	-1.9	-0.3	0.1
Indifference point function log k	0.9	1.2	3.5	-1.9	-0.3	0.1
Patch foraging total patch changes 0 sec	3.3	5.3	7.3	1.2	2.7	-2.7
Patch foraging total patch changes 12 sec	0.7	0.9	2.6	1.6	0.3	-0.3
Patch foraging total patch changes 18 sec	0.7	0.9	1.3	1.0	1.1	-0.8
Patch foraging total patch changes 24 sec	1.7	2.1	2.8	1.7	1.4	-1.3
Patch foraging total patch changes 6 sec	3.1	4.6	4.8	2.2	2.2	-2.0
Patch foraging time to switch 0 sec	1.5	2.3	3.6	-1.9	-1.3	1.4
Patch foraging water rate 0 sec	1.6	2.6	2.8	1.6	1.7	-1.6
Patch foraging water rate 12 sec	0.2	0.3	0.6	0.1	0.6	-0.8
Patch foraging water rate 18 sec	0.2	0.3	0.6	0.5	-0.8	0.4
Patch foraging water rate 24 sec	0.9	1.3	2.1	-0.4	-1.5	1.3
Patch foraging water rate 6 sec	0.4	0.6	1.7	1.3	0.1	-0.4
Seeking ratio, delayed vs. immediate footshock	1.3	1.4	4.2	2.0	-0.2	0.3
Distance traveled before self-admin	3.8	4.1	8.9	3.0	1.4	-1.2
Distance traveled after self-admin	0.8	0.9	2.2	1.5	-0.5	0.6
Extensor digitorum longus weight	1.8	7.0	19.8	4.5	0.8	-0.7
Bone: elastic displacement	3.5	3.9	8.0	-2.8	-1.3	1.4
Bone: elastic work	4.8	6.2	7.5	-2.1	-2.6	2.7
Bone: endosteal estimation	1.0	2.1	3.1	1.8	1.4	-1.2
Bone: endosteal perimeter	1.4	2.8	3.1	1.7	1.8	-1.5
Epididymis fat weight	0.4	0.8	1.6	1.3	0.8	-0.5
Delta time in closed arm before/after self-admin	1.1	1.1	1.4	1.0	-1.0	1.2
Delta time in open arm before/after self-admin	0.4	0.3	0.6	-0.2	0.6	-0.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.5	-0.1	0.3
Delay discount exponential model param	0.5	0.5	0.6	0.6	-0.6	0.8
Extinction: sum of active levers before priming	0.5	0.5	1.6	-1.3	-0.2	-0.1
Active lever presses in extinction session 6	0.5	0.5	1.2	-1.1	0.4	-0.4
Bone: final force	0.4	0.6	1.8	1.4	0.0	0.0
Bone: final moment	0.3	0.5	1.2	1.1	-0.3	0.3
Food consumed during 24 hour testing period	0.8	1.0	1.7	1.3	0.9	-0.7
Glucose	0.5	0.8	1.9	1.4	0.5	-0.4
Heart weight	0.5	0.7	0.9	0.9	0.8	-0.7
Delay discount hyperbolic model param	0.4	0.4	0.5	0.6	-0.6	0.7
Intermittent access intake day 1-15 change	1.2	1.2	1.7	0.6	-1.2	1.3
Intermittent access intake escalation	0.9	0.9	1.1	0.8	-1.0	1.1
Intermittent access intake escalation 2	2.3	2.3	3.3	1.0	-1.8	1.6
Intermitt. access day 1 inactive lever presses	0.3	0.4	0.9	0.9	0.4	-0.2
Intermitt. access day 15 inactive lever presses	0.3	0.4	0.5	0.5	0.7	-0.7
Intermitt. access escalation Index	1.2	1.0	1.4	1.2	0.8	-1.0
Intermittent access day 1 total infusions	0.9	1.1	1.7	-0.5	1.1	-1.3
Intermittent access day 15 total infusions	0.2	0.2	0.5	0.7	0.2	-0.1
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.7	1.3	0.3	-0.3
Intermittent access total infusions	0.6	0.6	1.2	1.1	0.6	-0.6
Intermittent access day 1 locomotion	1.0	1.1	1.3	-1.1	0.9	-1.0
Intermittent access day 15 total locomotion	0.3	0.3	0.8	-0.9	0.3	-0.3
Intermittent access total locomotion	0.3	0.3	0.8	-0.9	-0.3	0.2
Intermittent access standard deviation	0.4	0.4	0.7	0.8	-0.5	0.5
Left kidney weight	0.7	2.0	2.3	1.5	1.4	-1.3
Right kidney weight	0.3	0.8	1.2	0.5	1.1	-1.0
Cocaine induced anxiety	0.1	0.1	0.4	-0.6	-0.1	-0.1
Post-drug Anxiety	0.3	0.4	1.0	1.0	0.2	-0.3
Baseline Anxiety	0.3	0.3	0.4	0.6	-0.4	0.6
Tail length	1.2	3.5	7.6	2.8	1.2	-1.2
Length with tail	0.7	2.6	3.1	1.8	1.6	-1.4
Length without tail	0.2	0.3	0.8	-0.9	0.4	-0.3
Times rat made contact with spout	0.4	0.5	0.6	0.7	-0.5	0.8
Lifetime Intake	1.8	2.0	2.2	1.5	1.4	-1.4
Liver weight, left	0.3	0.5	1.4	1.2	0.2	-0.1
Liver weight, right	0.1	0.1	0.2	0.1	0.2	-0.5
Locomotor activity	0.0	0.0	0.1	0.3	-0.2	-0.1
Locomotor testing distance	0.4	0.7	1.4	0.3	0.8	-1.2
Locomotor testing rearing	0.8	1.3	2.7	1.6	0.6	-0.9
Locomotion in novel chamber	0.4	0.5	0.8	-0.4	-0.8	0.9
Locomotion in novel chamber post-restriction	1.6	1.9	2.5	0.9	-1.5	1.6
Fecal boli incidents, locomotor time 1	0.8	0.9	2.1	-1.5	-0.3	0.6
Change in fecal boli incidents, locomotor task	1.6	1.5	1.6	1.3	1.2	-1.2
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.6	0.3	1.3	-1.0
Bouts of movement, locomotor time 1	0.8	0.9	2.0	-1.4	-0.7	0.3
Total resting periods, locomotor time 1	1.6	1.8	3.2	-1.8	-1.2	0.8
Rest time, locomotor task time 1	4.6	5.1	6.1	-1.8	-2.5	2.5
Distance moved, locomotor task time 1	3.5	3.8	3.9	2.0	1.9	-1.9
Vertical activity count, locomotor time 1	4.1	4.3	5.4	1.8	2.1	-2.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.3	0.4	-0.3
Bouts of movement, locomotor time 2	0.2	0.3	0.7	0.9	-0.3	-0.1
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.5	-0.4	0.1
Rest time, locomotor task time 2	0.7	0.9	1.5	-1.2	-0.8	0.6
Distance moved, locomotor task time 2	0.3	0.4	0.5	0.7	-0.5	0.6
Vertical activity count, locomotor time 2	0.4	0.5	0.9	0.9	0.6	-0.5
Light reinforcement 1	4.2	7.7	10.0	2.1	2.9	-3.2
Light reinforcement 2	5.8	7.8	11.7	1.4	3.1	-3.4
Bone: marrow area	0.8	1.8	3.2	1.8	1.1	-1.0
Bone: maximum diameter	0.8	1.5	4.5	2.1	0.1	0.1
Bone: maximum force	1.0	1.7	4.9	2.2	-0.1	0.2
Bone: maximum moment	0.7	1.3	3.4	1.9	-0.4	0.5
Mean time between licks in bursts	0.1	0.2	0.5	-0.7	-0.1	0.3
Mean num. licks in bursts	1.1	1.3	3.6	-1.9	-0.5	0.2
Cd content in liver	0.6	0.7	0.9	1.0	-0.8	0.8
Co content in liver	0.6	0.7	1.1	-1.0	0.7	-0.7
Cu content in liver	0.9	1.1	1.2	-1.1	-1.0	1.1
Fe content in liver	2.4	2.9	4.1	0.7	2.0	-2.0
K content in liver	0.6	0.6	0.7	-0.5	0.9	-0.8
Mg content in liver	0.6	0.6	1.5	-1.2	0.4	-0.3
Mn content in liver	0.4	0.5	0.7	-0.1	-0.8	0.8
Na content in liver	0.4	0.4	1.1	-1.1	-0.2	0.1
Rb content in liver	1.5	1.8	5.2	-2.3	0.3	-0.3
Se content in liver	0.8	1.0	2.0	1.4	-0.7	0.8
Sr content in liver	0.1	0.1	0.3	0.5	-0.1	0.1
Zn content in liver	0.5	0.6	0.9	-0.2	-0.9	0.9
Bone: minimum diameter	0.1	0.2	0.2	-0.4	-0.4	0.5
Time in familiar zone, hab. session 1	4.9	4.6	6.5	-1.0	-2.6	2.5
Time in novel zone, hab. session 1	3.7	3.6	5.1	-0.8	2.3	-2.3
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.1	-0.1	0.1
Total locomotion distance, hab. session 1	1.0	1.4	2.0	0.4	-1.4	1.4
Locomotion velocity, hab. session 1	1.0	1.4	1.7	1.3	-1.1	1.1
Time in familiar zone, hab. session 2	2.3	2.4	3.1	-1.1	-1.8	1.7
Time in novel zone, hab. session 2	2.2	2.2	3.1	-0.8	1.7	-1.8
Total zone transitions, hab. session 2	0.9	1.2	1.4	1.0	1.2	-1.1
Total locomotion distance, hab. session 2	0.3	0.4	1.2	1.1	0.1	-0.0
Locomotion velocity, hab. session 2	0.4	0.5	1.5	1.2	0.0	0.1
Novel to familiar place preference ratio	1.9	2.0	2.7	-1.6	1.3	-1.3
Novelty place preference	2.0	2.1	4.0	-2.0	1.0	-1.1
Time in novel zone, NPP test	2.4	2.5	4.9	-2.2	1.1	-1.2
Total zone transitions, NPP test	1.3	1.8	2.0	1.3	1.4	-1.4
Total locomotion distance, NPP test	1.6	2.2	3.2	1.8	1.3	-1.3
Locomotion velocity, NPP test	1.4	2.0	4.1	2.0	1.0	-1.0
Intraocular pressure	1.5	2.1	4.1	2.0	1.0	-1.1
Delta distance traveled before/after self-admin	0.3	0.3	0.4	-0.4	-0.6	0.7
Delta ambulatory time before/after self-admin	0.7	0.8	1.0	-1.0	-0.8	0.8
Parametrial fat weight	0.2	0.4	0.5	0.6	0.7	-0.6
Pavlov. Cond. lever latency	3.3	4.1	11.0	-3.3	-0.8	0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.6	-0.1	0.2
Pavlov. Cond. change in total contacts	1.3	1.4	3.5	1.9	0.6	-0.5
Pavlov. Cond. index score	1.1	1.4	4.2	2.1	0.1	-0.0
Pavlov. Cond. latency score	1.1	1.4	4.0	2.0	0.2	-0.1
Pavlov. Cond. lever contacts	2.1	2.4	6.8	2.6	0.5	-0.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.9	-0.9	0.1	-0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.5	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	3.4	1.8	-0.2	0.3
Pavlov. Cond. response bias	1.1	1.4	4.0	2.0	0.2	-0.2
Pavlov. Cond. lever latency	1.4	1.9	2.3	-1.5	1.5	-1.2
Pavlov. Cond. magazine entry latency	0.4	0.4	0.5	-0.6	-0.7	0.6
Pavlov. Cond. change in total contacts	2.0	2.8	4.7	0.4	-2.2	1.9
Pavlov. Cond. index score	1.0	1.3	2.3	0.1	-1.5	1.3
Pavlov. Cond. latency score	1.3	1.6	2.6	0.2	-1.6	1.5
Pavlov. Cond. lever contacts	0.6	0.9	1.0	1.0	-1.0	0.7
Pavlov. Cond. magazine entry number	1.5	1.9	2.9	0.1	1.7	-1.7
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.7	0.8	0.6	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.5	0.1	-1.6	1.4
Pavlov. Cond. response bias	0.7	0.9	1.6	0.5	-1.3	0.9
Time in closed arm before self-admin	1.0	1.1	3.3	-1.8	-0.1	0.1
Time in closed arm after self-admin	0.4	0.4	0.6	-0.6	-0.5	0.8
Time in open arm before self-admin	2.0	2.2	3.3	1.8	1.3	-1.2
Time in open arm after self-admin	1.5	1.7	2.2	1.5	1.1	-1.3
Bone: periosteal estimation	0.7	1.4	3.7	1.9	0.5	-0.3
Bone: periosteal perimeter	0.7	1.2	1.3	1.1	1.2	-1.0
Bone: post-yield work	1.3	1.8	3.0	1.7	1.1	-1.1
Progressive ratio test 1 active lever presses	1.4	1.5	2.0	1.2	1.0	-1.4
Progressive ratio test 1 breakpoint	1.6	1.6	1.9	1.3	1.2	-1.4
Progressive ratio test 1 inactive lever presses	3.5	3.8	4.7	1.5	2.1	-2.2
Progressive ratio test 2 active lever presses	1.7	1.8	2.3	0.9	1.5	-1.5
Progressive ratio test 2 breakpoint	1.3	1.5	2.1	0.6	1.4	-1.4
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.1	1.1	0.5	-0.5
Incentive Sensitization - Responses	0.8	0.8	1.1	0.9	1.1	-0.7
Incentive Sensitization - Breakpoint	0.6	0.6	0.9	0.7	0.9	-0.7
Sum of active levers in priming session hrs 5-6	1.8	1.7	3.6	-1.9	0.9	-0.9
Progressive ratio	0.0	0.0	0.1	-0.1	0.2	-0.3
Food seeking constrained by brief footshock	6.4	7.9	16.2	4.0	1.9	-2.0
Seeking ratio, punishment vs. effort	1.5	1.8	4.6	2.1	0.6	-0.6
Retroperitoneal fat weight	0.1	0.4	0.7	-0.8	-0.4	0.6
Reaction time number correct	0.4	0.5	0.8	0.3	0.8	-0.9
Reaction time mean minus median	3.2	4.2	6.4	-0.0	-2.5	2.5
Reaction time mean minus median AUC	2.0	2.6	4.0	0.6	-2.0	1.8
Reaction time num false alarms	0.4	0.6	1.1	-0.2	-1.1	0.7
Reaction time num false alarms AUC	0.1	0.1	0.2	0.5	-0.4	0.1
Reaction time trials correct on left	0.4	0.5	0.8	0.3	0.8	-0.9
Reaction time trials on left	0.3	0.4	0.7	0.2	0.8	-0.8
Reaction time mean	3.1	4.4	5.8	-1.6	-2.2	2.4
Reaction time mean AUC	3.6	4.9	6.1	-1.7	-2.4	2.5
Median of all reaction times	2.3	3.2	4.3	-2.1	-1.5	1.7
Reaction time omissions	0.9	1.3	2.8	-1.7	-0.7	0.8
Reaction time false alarm rate	0.4	0.5	1.1	-0.3	-1.0	0.7
Reaction time premature initiation rate	2.2	2.9	4.8	-2.2	-1.4	1.4
Reaction time premature initiations	1.1	1.6	3.3	-1.8	-0.9	0.8
Std. dev. reaction times	3.3	4.7	6.9	-0.8	-2.6	2.5
Reaction time trials completed	0.3	0.4	0.7	0.2	0.8	-0.8
Reaction time trials AUC	0.3	0.4	0.6	0.1	0.8	-0.8
Run reversals in cocaine runway, females	0.6	0.5	0.8	-0.3	-0.8	0.9
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.1	-0.2	0.2
Latency to leave start box in cocaine runway	0.3	0.3	0.6	0.8	-0.3	0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.2	0.4	-0.2
Latency to leave start box in cocaine runway, M	1.1	1.1	2.5	1.6	0.6	-0.6
Std. dev. time between licks in bursts	0.2	0.3	0.6	-0.8	-0.4	0.2
Total sessions with >9 infusions	2.6	2.9	4.2	0.9	1.9	-2.0
Short access day 1 total inactive lever presses	2.5	2.8	5.7	2.4	1.2	-1.1
Short access day 10 total inactive lever presses	0.2	0.2	0.5	0.7	-0.2	0.1
Short access day 1 total infusions	4.3	4.6	5.0	2.2	2.0	-2.2
Short access day 10 total infusions	2.2	2.5	3.2	1.1	1.8	-1.7
Short access total infusions	3.0	3.4	4.5	1.4	1.9	-2.1
Short access day 1 locomotion	0.8	0.8	1.5	-0.3	0.9	-1.2
Short access day 10 total locomotion	0.8	0.9	1.4	-1.2	-0.9	0.7
Short access total locomotion	0.7	0.7	1.3	0.2	0.9	-1.1
One hour access (0.3 mA shock)	0.9	1.1	1.3	0.9	1.1	-1.0
Compulsive drug intake	0.3	0.3	0.7	0.5	0.9	-0.2
One hour access (shock baseline)	0.9	1.0	1.5	0.8	1.0	-1.2
Social response proportion	1.3	1.4	2.4	-1.5	-0.6	1.2
Social responses	0.2	0.3	0.9	0.9	0.2	0.0
Social time	0.1	0.1	0.2	-0.1	0.5	-0.1
Soleus weight	1.7	5.0	7.8	0.3	2.7	-2.8
Bone: stiffness	1.3	2.1	6.3	2.5	-0.1	0.1
Tibialis anterior weight	3.5	12.0	29.9	5.5	1.7	-1.8
Time to tail flick, vehicle, before self-admin	1.3	1.3	3.5	-1.9	-0.5	0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.2	0.1	-0.2
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.7	-0.2	0.4
Time to tail flick, test, after self-admin	0.6	0.6	1.0	0.2	-0.9	1.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.2	1.1	0.3	-0.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	-0.6	-0.3	0.3
Tibia length	0.8	2.3	3.6	0.5	1.9	-1.7
Ambulatory time before self-admin	3.7	3.8	6.5	2.6	1.6	-1.5
Ambulatory time after self-admin	0.3	0.4	0.9	0.9	0.5	-0.2
Bone: tissue strength	0.1	0.1	0.1	0.4	-0.2	0.4
Total heroin consumption	0.8	0.9	1.7	-0.4	1.0	-1.3
Bone: trabecular number	0.5	0.8	1.1	1.0	-0.9	0.7
Bone: trabecular spacing	0.3	0.4	0.8	-0.0	-0.7	0.9
Bone: trabecular thickness	0.1	0.2	0.3	-0.5	-0.4	0.2
Bone: trabecular tissue density	1.3	1.9	5.5	2.3	0.1	-0.3
Water consumed over 24 hours	0.4	0.5	1.5	1.2	0.1	0.2
Number of responses in last shaping day	4.2	4.4	6.1	1.1	2.4	-2.5