Hub : Genes

Nefm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Nefm 0.29 0.24 1.2e-08 0.2 0.2 0.2 0.18 6.6e-09 9.1e-09 6.2e-09 4.9e-08
2 Adipose gene expression Nefm 0.3 0.22 0.0e+00 0.25 0.24 0.24 0.24 3.7e-27 8.1e-27 1.1e-26 7.5e-27
3 LHb gene expression Nefm 0.25 0.2 4.5e-04 0.03 0.04 0.03 0.03 7.2e-02 3.2e-02 8.4e-02 5.8e-02
4 NAcc gene expression Nefm 0.09 0.07 2.7e-13 0.08 0.08 0.08 0.08 3.1e-12 1.8e-12 3.7e-12 2.5e-12
5 PL gene expression Nefm 0.04 0.04 1.5e-04 0.03 0.03 0.03 0.03 2.5e-04 2.1e-04 6.5e-04 3.3e-04
6 BLA gene expression Nefm 0.16 0.15 7.9e-05 0.04 0.04 0.04 0.04 2.0e-03 4.3e-03 2.3e-03 2.1e-03
7 Brain gene expression Nefm 0.19 0.13 0.0e+00 0.19 0.19 0.18 0.19 8.9e-18 2.4e-17 5.2e-17 1.3e-17
8 IL gene expression Nefm 0.28 0.21 1.9e-04 0.12 0.12 0.13 0.12 9.6e-04 1.0e-03 5.3e-04 1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.42.53.01.61.5-1.6-1.6-1.61.71.61.4
Area under the delay curve0.10.10.1-0.4-0.40.40.40.4-0.3-0.3-0.2
BMI with tail0.31.01.4-1.2-1.01.11.11.1-1.0-0.9-0.7
BMI without tail0.00.00.00.00.2-0.0-0.0-0.00.00.10.1
Body weight0.62.63.1-1.8-1.61.71.71.7-1.6-1.6-1.2
Weight adjusted by age0.72.12.6-1.6-1.51.51.51.5-1.5-1.4-1.1
Bone surface0.71.41.61.11.1-1.2-1.2-1.21.31.21.0
Bone volume0.71.51.91.11.2-1.2-1.2-1.21.41.21.1
Breakpoint value in progressive ratio session0.10.10.2-0.3-0.40.30.30.3-0.4-0.3-0.4
Number of licking bursts0.00.00.1-0.1-0.30.10.10.1-0.0-0.00.1
Context. condit. distance diff. score0.91.01.31.00.8-1.0-1.0-1.01.21.11.0
Locomotion velocity, session 10.20.30.4-0.6-0.60.50.50.5-0.5-0.3-0.2
Locomotion distance, session 10.00.00.1-0.1-0.10.10.10.1-0.3-0.0-0.0
Locomotion velocity, session 20.00.00.00.10.1-0.0-0.0-0.0-0.0-0.1-0.2
Locomotion distance, session 20.00.00.00.10.10.00.00.0-0.20.0-0.0
Locomotion velocity, session 30.70.81.0-0.9-0.80.90.90.9-1.0-0.9-0.8
Locomotion distance, session 30.10.10.30.20.20.10.10.1-0.3-0.4-0.5
Stereotopy head waving bouts, day 30.70.81.0-1.0-1.00.90.90.9-1.0-0.8-0.6
Stereotopy head waving duration, day 32.12.63.2-1.8-1.81.71.71.7-1.6-1.4-1.1
Locomotion velocity, session 74.04.45.62.22.4-2.1-2.1-2.12.02.11.7
Locomotion distance, session 73.84.85.52.12.3-2.2-2.2-2.22.22.32.0
Stereotopy head waving bouts, day 71.31.52.2-1.1-1.11.21.21.2-1.2-1.5-1.3
Stereotopy head waving duration, day 72.02.53.2-1.4-1.41.61.61.6-1.6-1.8-1.6
Locomotion velocity, session 80.00.00.0-0.00.00.10.10.1-0.2-0.1-0.1
Locomotion distance, session 80.50.70.90.90.7-0.9-0.9-0.90.90.90.8
Degree of sensitization distance6.36.89.42.22.4-2.5-2.5-2.52.83.12.8
Degree of sensitization stereotypy1.01.11.8-0.9-0.91.01.01.0-1.0-1.3-1.2
Conditioned locomotion0.00.00.10.20.3-0.1-0.1-0.10.0-0.2-0.2
Cocaine response after cond. corrected0.30.50.8-0.5-0.60.70.70.7-0.9-0.8-0.7
Cocaine response after cond. not corrected0.20.30.6-0.4-0.50.50.50.5-0.8-0.6-0.6
Cocaine response before conditioning0.20.30.40.50.5-0.5-0.6-0.60.60.60.5
Saline control response0.20.30.50.50.4-0.5-0.6-0.60.70.70.6
Bone: connectivity density2.64.24.72.22.0-2.1-2.1-2.12.12.11.7
Bone: cortical apparent density0.00.10.10.20.2-0.3-0.3-0.30.30.30.2
Bone: cortical area0.00.00.00.00.2-0.1-0.1-0.10.20.10.2
Bone: cortical porosity1.41.62.1-1.2-1.51.21.21.2-1.3-1.3-1.1
Bone: cortical porosity0.90.91.4-0.9-1.21.01.01.0-1.0-1.0-0.8
Bone: cortical thickness0.00.00.00.0-0.0-0.0-0.0-0.00.1-0.10.0
Bone: cortical thickness0.00.00.20.10.4-0.1-0.1-0.10.0-0.0-0.0
Bone: cortical tissue density0.10.10.10.30.3-0.3-0.3-0.30.40.40.3
Condit. Reinf. active minus inactive responses0.70.70.9-0.9-1.00.90.90.9-0.9-0.8-0.6
Condit. Reinf. active-inactive response ratio2.62.83.1-1.7-1.81.71.71.7-1.7-1.6-1.3
Condit. Reinf. active responses0.00.00.1-0.2-0.20.20.20.2-0.1-0.00.1
Condit. Reinf. inactive responses2.33.03.61.71.8-1.7-1.7-1.71.91.81.5
Incentive salience index mean1.01.31.6-1.2-1.21.21.21.2-1.2-1.1-0.8
Condit. Reinf. lever presses0.50.70.8-0.9-0.90.90.90.9-0.9-0.9-0.7
Condit. Reinf. active minus inactive responses0.30.50.60.70.8-0.7-0.7-0.70.80.70.6
Condit. Reinf. active-inactive response ratio0.00.00.0-0.2-0.10.10.10.10.1-0.1-0.0
Condit. Reinf. active responses0.91.31.41.11.2-1.2-1.2-1.21.21.21.0
Condit. Reinf. inactive responses1.52.32.51.61.5-1.6-1.6-1.61.51.61.3
Condit. Reinf. lever presses0.10.20.30.40.5-0.4-0.4-0.40.40.40.4
Condit. Reinf. lever reinforcers received0.81.11.31.01.0-1.0-1.0-1.01.11.11.0
Conditioned reinforcement - actives0.41.71.81.31.3-1.3-1.3-1.31.31.41.1
Conditioned reinforcement - inactives1.74.75.32.22.1-2.2-2.2-2.22.22.31.9
Conditioned locomotion0.10.20.20.40.4-0.4-0.4-0.40.50.40.4
Patch foraging indifference point 0 sec1.33.64.91.82.2-1.9-1.9-1.91.92.01.6
Patch foraging indifference point AUC0.20.50.7-0.7-0.80.70.70.7-0.9-0.7-0.6
Delay disc. indifference point, 0s delay0.20.20.40.20.3-0.4-0.4-0.40.60.60.5
Delay disc. indifference point, 16s delay0.20.30.40.60.6-0.6-0.6-0.60.60.60.5
Delay disc. indifference point, 2s delay1.31.51.7-1.3-1.31.31.31.3-1.2-1.2-0.8
Delay disc. indifference point, 24s delay0.10.20.3-0.6-0.50.50.50.5-0.4-0.4-0.2
Delay disc. indifference point, 4s delay1.81.92.1-1.4-1.41.41.41.4-1.4-1.4-1.1
Delay disc. indifference point, 8s delay0.00.00.0-0.1-0.10.10.10.10.00.00.1
Indifference point function ln k0.00.10.20.10.4-0.2-0.2-0.20.30.30.3
Indifference point function log k0.00.10.20.10.4-0.2-0.2-0.20.30.30.3
Patch foraging total patch changes 0 sec0.92.74.01.62.0-1.6-1.6-1.61.61.81.4
Patch foraging total patch changes 12 sec0.50.71.00.81.0-0.9-0.9-0.90.70.90.7
Patch foraging total patch changes 18 sec0.61.51.81.31.3-1.3-1.3-1.31.11.21.0
Patch foraging total patch changes 24 sec0.00.00.0-0.10.20.10.10.1-0.2-0.0-0.1
Patch foraging total patch changes 6 sec0.20.40.70.50.7-0.6-0.6-0.60.60.80.7
Patch foraging time to switch 0 sec0.31.01.31.10.9-1.1-1.1-1.11.10.90.7
Patch foraging water rate 0 sec0.20.71.0-0.8-0.60.90.90.9-1.0-0.8-0.8
Patch foraging water rate 12 sec0.20.91.1-1.0-0.81.01.01.0-1.0-1.0-0.8
Patch foraging water rate 18 sec1.63.54.2-2.0-1.92.02.02.0-1.8-1.8-1.5
Patch foraging water rate 24 sec0.10.10.3-0.5-0.40.40.40.4-0.3-0.2-0.3
Patch foraging water rate 6 sec2.23.23.7-1.9-1.81.91.91.9-1.7-1.8-1.5
Seeking ratio, delayed vs. immediate footshock0.50.71.31.11.1-0.9-0.9-0.90.60.60.3
Distance traveled before self-admin0.40.81.0-0.9-1.00.90.90.9-1.0-0.9-0.8
Distance traveled after self-admin1.83.23.6-1.9-1.91.91.91.9-1.9-1.7-1.3
Extensor digitorum longus weight12.148.452.2-7.2-6.87.27.27.2-7.1-7.1-5.8
Bone: elastic displacement0.30.30.50.70.4-0.6-0.6-0.60.60.50.4
Bone: elastic work0.20.20.30.50.4-0.5-0.5-0.50.60.50.4
Bone: endosteal estimation0.00.00.1-0.3-0.10.10.10.10.00.10.3
Bone: endosteal perimeter0.00.00.0-0.20.00.10.10.1-0.10.10.2
Epididymis fat weight0.52.63.11.51.6-1.6-1.6-1.61.81.81.6
Delta time in closed arm before/after self-admin3.12.94.11.72.0-1.7-1.7-1.71.71.61.4
Delta time in open arm before/after self-admin0.00.00.2-0.0-0.50.10.10.1-0.0-0.1-0.1
Diff in mean of infusions in LGA sessions0.30.61.1-0.9-1.00.80.80.8-0.7-0.7-0.4
Delay discount exponential model param0.30.50.50.70.7-0.7-0.7-0.70.70.70.5
Extinction: sum of active levers before priming1.32.02.71.31.5-1.4-1.4-1.41.31.61.4
Active lever presses in extinction session 60.20.20.30.60.4-0.5-0.5-0.50.40.50.3
Bone: final force0.00.10.2-0.4-0.30.30.30.3-0.0-0.10.0
Bone: final moment0.00.00.1-0.3-0.20.20.20.20.00.00.1
Food consumed during 24 hour testing period0.20.40.70.60.5-0.6-0.6-0.60.60.90.8
Glucose0.00.00.10.00.1-0.1-0.1-0.10.20.20.3
Heart weight0.61.01.40.80.9-1.0-1.0-1.01.11.21.1
Delay discount hyperbolic model param0.50.60.70.80.8-0.8-0.8-0.80.80.70.5
Intermittent access intake day 1-15 change0.63.53.71.91.9-1.9-1.9-1.91.91.91.6
Intermittent access intake escalation0.73.63.91.91.9-1.9-1.9-1.91.92.01.6
Intermittent access intake escalation 21.01.72.01.31.3-1.3-1.3-1.31.41.41.2
Intermitt. access day 1 inactive lever presses0.00.00.00.10.1-0.1-0.1-0.10.10.20.1
Intermitt. access day 15 inactive lever presses0.00.00.10.20.2-0.2-0.2-0.20.20.20.2
Intermitt. access escalation Index0.00.10.1-0.2-0.20.20.20.2-0.2-0.2-0.2
Intermittent access day 1 total infusions0.00.00.00.0-0.0-0.0-0.0-0.00.10.00.1
Intermittent access day 15 total infusions1.02.52.71.61.6-1.6-1.6-1.61.61.61.4
Intermittent access terminal intake (last 3 days)0.81.41.51.21.2-1.2-1.2-1.21.21.21.0
Intermittent access total infusions1.11.31.41.21.2-1.2-1.2-1.21.11.21.0
Intermittent access day 1 locomotion0.00.00.00.20.1-0.1-0.1-0.10.10.10.1
Intermittent access day 15 total locomotion0.10.40.40.60.6-0.6-0.6-0.60.60.60.5
Intermittent access total locomotion0.10.10.10.30.3-0.3-0.3-0.30.30.40.3
Intermittent access standard deviation0.10.30.40.50.5-0.6-0.6-0.60.60.60.5
Left kidney weight0.00.10.1-0.4-0.20.30.30.3-0.2-0.3-0.1
Right kidney weight0.00.00.0-0.20.00.20.20.2-0.1-0.1-0.1
Cocaine induced anxiety0.00.00.0-0.0-0.00.10.10.1-0.10.00.0
Post-drug Anxiety0.70.71.01.01.0-0.9-0.9-0.90.80.80.6
Baseline Anxiety0.20.40.50.70.7-0.7-0.7-0.70.60.50.4
Tail length0.31.62.11.31.4-1.3-1.3-1.31.21.21.0
Length with tail0.00.20.3-0.5-0.40.50.50.5-0.4-0.5-0.4
Length without tail1.36.77.3-2.7-2.72.72.72.7-2.5-2.7-2.1
Times rat made contact with spout0.60.70.90.70.7-0.8-0.8-0.80.91.00.9
Lifetime Intake0.60.80.80.90.9-0.9-0.9-0.90.90.90.8
Liver weight, left1.62.73.6-1.9-1.81.71.71.7-1.6-1.5-1.1
Liver weight, right0.50.91.0-1.0-0.81.01.01.0-1.0-1.0-0.8
Locomotor activity1.42.22.6-1.6-1.31.51.51.5-1.6-1.6-1.3
Locomotor testing distance0.00.10.10.30.3-0.3-0.3-0.30.30.30.2
Locomotor testing rearing0.10.30.40.60.5-0.6-0.6-0.60.60.50.4
Locomotion in novel chamber0.50.71.00.70.7-0.8-0.8-0.80.91.00.8
Locomotion in novel chamber post-restriction0.41.21.6-1.1-1.01.11.11.1-1.2-1.3-1.1
Fecal boli incidents, locomotor time 10.41.01.7-1.1-1.31.01.01.0-1.0-0.8-0.6
Change in fecal boli incidents, locomotor task0.20.30.4-0.4-0.40.50.50.5-0.6-0.6-0.5
Time >=10cm from walls, locomotor time 11.01.31.51.21.0-1.1-1.1-1.21.21.21.0
Bouts of movement, locomotor time 14.45.66.2-2.5-2.42.42.42.4-2.5-2.4-1.9
Total resting periods, locomotor time 14.85.56.2-2.5-2.42.42.42.4-2.4-2.3-1.9
Rest time, locomotor task time 11.52.42.9-1.7-1.31.61.61.6-1.6-1.6-1.3
Distance moved, locomotor task time 10.92.72.91.71.7-1.7-1.7-1.71.71.61.3
Vertical activity count, locomotor time 10.10.71.21.01.1-0.9-0.9-0.90.80.70.5
Time >=10cm from walls, locomotor time 20.10.40.5-0.7-0.60.70.70.7-0.7-0.6-0.5
Bouts of movement, locomotor time 21.44.85.4-2.3-2.32.22.22.2-2.3-2.1-1.6
Total resting periods, locomotor time 21.35.05.6-2.4-2.42.32.32.3-2.3-2.2-1.7
Rest time, locomotor task time 20.61.11.2-1.1-0.91.11.11.1-1.0-1.1-0.8
Distance moved, locomotor task time 22.12.83.21.71.8-1.7-1.7-1.71.81.71.3
Vertical activity count, locomotor time 20.10.30.50.60.7-0.6-0.6-0.60.60.50.4
Light reinforcement 11.14.95.62.42.2-2.3-2.3-2.32.32.21.6
Light reinforcement 20.61.41.61.31.1-1.2-1.2-1.21.21.20.9
Bone: marrow area0.00.00.1-0.2-0.00.0-0.00.00.10.30.4
Bone: maximum diameter0.20.40.6-0.7-0.60.70.70.7-0.6-0.6-0.4
Bone: maximum force0.10.30.5-0.7-0.50.60.60.6-0.3-0.4-0.2
Bone: maximum moment0.10.10.3-0.5-0.30.40.40.4-0.2-0.2-0.1
Mean time between licks in bursts0.42.42.61.61.6-1.6-1.6-1.61.51.61.3
Mean num. licks in bursts0.20.50.70.60.8-0.7-0.7-0.70.70.70.6
Cd content in liver1.41.52.5-1.2-1.61.21.21.2-1.2-1.2-1.0
Co content in liver4.85.66.3-2.5-2.52.42.42.4-2.4-2.3-1.8
Cu content in liver0.50.50.6-0.7-0.70.80.80.8-0.7-0.8-0.7
Fe content in liver1.72.02.21.51.4-1.5-1.5-1.51.51.51.2
K content in liver1.01.01.41.11.2-1.1-1.1-1.10.90.80.6
Mg content in liver2.12.33.61.71.9-1.6-1.6-1.61.41.30.9
Mn content in liver2.42.73.11.61.8-1.6-1.6-1.61.71.71.4
Na content in liver1.11.21.4-1.2-0.81.21.21.2-1.2-1.2-1.0
Rb content in liver0.00.00.10.30.3-0.2-0.2-0.20.10.1-0.0
Se content in liver0.91.11.41.11.2-1.1-1.1-1.11.01.00.7
Sr content in liver0.00.00.00.1-0.0-0.0-0.0-0.00.00.10.1
Zn content in liver0.10.10.20.40.5-0.3-0.3-0.30.30.30.2
Bone: minimum diameter0.00.10.2-0.4-0.20.30.30.3-0.2-0.10.1
Time in familiar zone, hab. session 10.00.00.0-0.1-0.10.10.10.10.1-0.10.0
Time in novel zone, hab. session 11.21.31.7-1.1-1.21.21.21.2-1.3-1.1-0.9
Total zone transitions, hab. session 10.30.40.7-0.7-0.80.60.60.6-0.7-0.4-0.2
Total locomotion distance, hab. session 10.00.00.0-0.1-0.20.10.10.0-0.20.10.2
Locomotion velocity, hab. session 10.10.10.20.20.2-0.3-0.3-0.30.20.40.4
Time in familiar zone, hab. session 21.71.93.2-1.6-1.81.41.41.4-1.1-1.2-0.8
Time in novel zone, hab. session 20.60.71.41.01.2-0.8-0.8-0.80.60.70.4
Total zone transitions, hab. session 21.72.22.7-1.4-1.41.51.51.5-1.6-1.6-1.3
Total locomotion distance, hab. session 20.50.60.9-0.7-0.70.80.80.8-0.9-0.9-0.8
Locomotion velocity, hab. session 20.91.21.5-1.0-1.11.11.11.1-1.2-1.2-1.0
Novel to familiar place preference ratio1.01.32.11.41.5-1.2-1.2-1.20.90.90.6
Novelty place preference0.81.01.71.31.3-1.1-1.1-1.10.80.80.5
Time in novel zone, NPP test0.40.51.00.91.0-0.7-0.7-0.70.40.50.2
Total zone transitions, NPP test0.00.10.10.30.1-0.3-0.3-0.30.20.30.3
Total locomotion distance, NPP test2.12.93.01.71.7-1.7-1.7-1.71.61.71.5
Locomotion velocity, NPP test2.02.83.01.71.7-1.7-1.7-1.71.61.71.5
Intraocular pressure0.50.81.10.70.9-0.8-0.8-0.80.91.00.9
Delta distance traveled before/after self-admin3.23.54.0-2.0-2.01.92.01.9-1.9-1.8-1.4
Delta ambulatory time before/after self-admin2.13.64.1-2.0-2.02.02.02.0-1.9-1.8-1.4
Parametrial fat weight2.14.85.22.32.2-2.3-2.3-2.32.22.21.9
Pavlov. Cond. lever latency0.00.00.00.0-0.1-0.1-0.1-0.10.10.20.2
Pavlov. Cond. magazine entry latency0.10.10.20.10.2-0.2-0.2-0.20.40.50.5
Pavlov. Cond. change in total contacts1.11.21.5-1.2-0.91.11.11.1-1.0-1.2-1.0
Pavlov. Cond. index score0.10.10.1-0.3-0.20.30.30.3-0.2-0.3-0.3
Pavlov. Cond. latency score0.00.00.0-0.2-0.10.20.20.2-0.1-0.2-0.1
Pavlov. Cond. lever contacts0.00.00.00.10.1-0.0-0.0-0.0-0.0-0.1-0.1
Pavlov. Cond. magazine entry number0.20.30.50.70.7-0.6-0.6-0.60.40.40.3
Pavlov. Cond. intertrial magazine entries0.10.10.10.30.3-0.3-0.3-0.30.30.30.3
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.5-0.40.50.50.5-0.4-0.5-0.4
Pavlov. Cond. response bias0.10.10.2-0.5-0.40.40.40.4-0.3-0.3-0.2
Pavlov. Cond. lever latency0.50.70.80.80.8-0.8-0.8-0.80.80.90.7
Pavlov. Cond. magazine entry latency0.00.00.10.20.3-0.2-0.2-0.20.30.20.2
Pavlov. Cond. change in total contacts0.81.92.1-1.5-1.21.41.41.4-1.4-1.4-1.1
Pavlov. Cond. index score0.40.60.7-0.8-0.70.80.80.8-0.8-0.8-0.6
Pavlov. Cond. latency score0.20.40.5-0.7-0.60.60.60.6-0.6-0.6-0.5
Pavlov. Cond. lever contacts0.20.30.4-0.6-0.60.60.60.6-0.6-0.6-0.5
Pavlov. Cond. magazine entry number0.00.00.0-0.1-0.20.10.10.1-0.1-0.0-0.0
Pavlov. Cond. intertrial magazine entries3.78.09.02.92.5-2.9-2.9-2.93.03.02.5
Pavlov. Cond. lever-magazine prob. diff.0.50.70.8-0.9-0.80.90.90.9-0.8-0.9-0.7
Pavlov. Cond. response bias0.30.40.6-0.6-0.60.60.60.6-0.7-0.7-0.6
Time in closed arm before self-admin0.81.42.3-1.1-1.51.11.11.1-1.1-1.2-1.1
Time in closed arm after self-admin0.00.00.0-0.0-0.00.00.00.00.0-0.2-0.1
Time in open arm before self-admin0.00.00.1-0.20.20.10.20.2-0.2-0.2-0.1
Time in open arm after self-admin0.00.00.00.00.1-0.0-0.0-0.00.00.20.2
Bone: periosteal estimation0.00.00.1-0.2-0.00.10.10.10.10.10.3
Bone: periosteal perimeter0.00.00.0-0.10.10.10.10.1-0.10.00.1
Bone: post-yield work0.20.30.50.40.4-0.5-0.5-0.50.70.60.5
Progressive ratio test 1 active lever presses0.00.10.1-0.2-0.30.20.20.2-0.2-0.2-0.1
Progressive ratio test 1 breakpoint0.10.10.2-0.3-0.40.30.30.3-0.3-0.3-0.2
Progressive ratio test 1 inactive lever presses0.51.31.51.11.1-1.1-1.1-1.11.21.21.0
Progressive ratio test 2 active lever presses0.00.00.00.10.2-0.1-0.1-0.10.00.20.2
Progressive ratio test 2 breakpoint0.00.00.00.00.1-0.1-0.1-0.1-0.00.10.1
Progressive ratio test 2 inactive lever presses0.10.40.40.60.6-0.6-0.6-0.60.60.60.5
Incentive Sensitization - Responses0.10.20.30.40.6-0.5-0.5-0.50.40.50.5
Incentive Sensitization - Breakpoint0.10.30.40.50.7-0.6-0.6-0.60.50.70.6
Sum of active levers in priming session hrs 5-60.00.00.10.10.3-0.1-0.1-0.10.10.20.2
Progressive ratio0.00.10.2-0.1-0.20.30.30.3-0.4-0.5-0.5
Food seeking constrained by brief footshock1.92.42.8-1.7-1.61.61.61.6-1.5-1.5-1.1
Seeking ratio, punishment vs. effort0.30.61.0-1.0-0.90.80.80.8-0.6-0.6-0.3
Retroperitoneal fat weight0.10.60.80.60.6-0.7-0.7-0.70.90.90.8
Reaction time number correct0.31.01.4-1.2-1.21.01.01.0-0.9-0.8-0.5
Reaction time mean minus median0.10.30.4-0.6-0.60.60.60.6-0.6-0.5-0.4
Reaction time mean minus median AUC0.00.30.4-0.5-0.70.50.50.5-0.5-0.5-0.3
Reaction time num false alarms0.00.00.1-0.3-0.20.20.20.20.20.20.3
Reaction time num false alarms AUC0.00.00.1-0.2-0.10.10.10.10.20.20.3
Reaction time trials correct on left0.31.01.4-1.2-1.21.01.01.0-0.9-0.8-0.5
Reaction time trials on left0.20.71.2-1.0-1.10.90.90.9-0.8-0.6-0.4
Reaction time mean0.20.50.5-0.7-0.60.70.70.7-0.7-0.7-0.5
Reaction time mean AUC0.30.80.8-0.9-0.80.90.90.9-0.9-0.9-0.7
Median of all reaction times0.20.40.5-0.7-0.50.70.70.7-0.7-0.6-0.5
Reaction time omissions1.52.42.61.61.5-1.6-1.6-1.61.61.61.3
Reaction time false alarm rate0.20.30.40.40.6-0.5-0.5-0.50.70.60.5
Reaction time premature initiation rate1.52.32.6-1.5-1.61.51.61.5-1.6-1.6-1.2
Reaction time premature initiations1.13.54.3-2.0-2.11.91.91.9-1.9-1.8-1.4
Std. dev. reaction times0.10.40.4-0.6-0.60.60.60.6-0.6-0.6-0.4
Reaction time trials completed0.20.71.2-1.0-1.10.90.90.9-0.8-0.6-0.4
Reaction time trials AUC0.20.71.0-1.0-1.00.90.90.9-0.8-0.6-0.4
Run reversals in cocaine runway, females2.62.93.81.71.6-1.7-1.7-1.81.91.71.4
Run reversals in cocaine runway, males1.61.82.0-1.4-1.41.41.41.4-1.4-1.3-1.1
Latency to leave start box in cocaine runway0.60.81.3-0.8-0.60.90.90.9-1.1-1.0-1.0
Latency to leave start box in cocaine runway, F1.82.23.3-1.2-1.11.41.41.4-1.8-1.7-1.6
Latency to leave start box in cocaine runway, M0.10.10.20.10.3-0.3-0.3-0.30.30.40.4
Std. dev. time between licks in bursts1.12.02.61.31.1-1.4-1.4-1.41.51.61.4
Total sessions with >9 infusions0.00.00.1-0.2-0.20.20.20.2-0.1-0.1-0.0
Short access day 1 total inactive lever presses0.10.10.20.40.4-0.4-0.4-0.40.40.30.3
Short access day 10 total inactive lever presses0.00.20.20.50.5-0.5-0.5-0.50.40.40.3
Short access day 1 total infusions0.00.10.2-0.3-0.30.30.30.3-0.3-0.4-0.3
Short access day 10 total infusions0.20.30.4-0.6-0.60.60.60.6-0.5-0.6-0.4
Short access total infusions0.00.00.1-0.2-0.20.20.20.2-0.2-0.2-0.1
Short access day 1 locomotion0.61.01.1-1.0-1.01.01.01.0-1.0-1.1-0.9
Short access day 10 total locomotion0.00.00.10.20.1-0.2-0.2-0.20.30.10.1
Short access total locomotion0.10.10.1-0.3-0.40.30.30.3-0.2-0.3-0.2
One hour access (0.3 mA shock)0.70.80.90.90.9-0.9-0.9-0.90.80.90.8
Compulsive drug intake0.40.60.80.90.9-0.8-0.8-0.80.70.70.5
One hour access (shock baseline)0.00.00.0-0.0-0.0-0.0-0.0-0.00.00.10.1
Social response proportion0.20.20.3-0.4-0.30.40.50.5-0.4-0.5-0.5
Social responses1.11.41.91.11.3-1.1-1.1-1.11.41.31.1
Social time0.20.30.50.70.7-0.6-0.6-0.50.30.40.2
Soleus weight1.23.44.4-1.9-2.11.91.91.9-1.9-1.8-1.4
Bone: stiffness0.40.81.1-1.1-0.81.01.01.0-0.8-0.8-0.6
Tibialis anterior weight8.027.429.4-5.4-5.25.45.45.4-5.4-5.3-4.3
Time to tail flick, vehicle, before self-admin0.81.01.11.11.0-1.1-1.1-1.11.01.10.8
Time to tail flick, vehicle, after self-admin1.02.02.9-1.2-1.71.31.31.3-1.3-1.5-1.4
Time to tail flick, test, before self-admin2.73.13.71.81.8-1.8-1.8-1.81.71.91.5
Time to tail flick, test, after self-admin2.12.22.91.71.6-1.5-1.5-1.51.41.31.0
Delta time to tail flick, vehicle, before/after SA0.40.40.6-0.5-0.70.60.60.6-0.5-0.8-0.7
Delta time to tail flick, test, before/after SA0.00.00.00.10.1-0.1-0.1-0.10.0-0.2-0.2
Tibia length1.23.24.21.92.0-1.8-1.8-1.81.81.71.3
Ambulatory time before self-admin0.10.20.3-0.4-0.60.50.50.5-0.6-0.5-0.5
Ambulatory time after self-admin3.96.36.9-2.6-2.62.62.62.6-2.6-2.5-2.0
Bone: tissue strength0.10.10.30.30.2-0.3-0.3-0.30.60.40.4
Total heroin consumption0.60.71.1-0.8-1.00.80.80.8-0.9-0.8-0.8
Bone: trabecular number2.13.94.42.11.9-2.1-2.1-2.12.02.01.6
Bone: trabecular spacing2.02.93.2-1.8-1.71.81.81.8-1.6-1.8-1.4
Bone: trabecular thickness1.01.31.61.21.3-1.2-1.2-1.21.21.20.9
Bone: trabecular tissue density1.22.12.9-1.5-1.71.51.51.5-1.4-1.3-1.0
Water consumed over 24 hours0.81.52.0-1.4-1.41.31.31.3-1.3-1.0-0.7
Number of responses in last shaping day0.50.60.7-0.8-0.80.80.80.8-0.8-0.8-0.7