Hub : Genes

Ppp2r2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Ppp2r2a	0.04	0.03	1.2e-03	0.04	0.03	0.02	0.03	2.1e-04	2.1e-03	6.6e-03	7.2e-04
2	RMTg	alternative TSS	XM_063273918.1	0.13	0.09	4.0e-03	0.07	0.05	-0.01	0.02	5.4e-03	2.1e-02	5.4e-01	7.5e-02
3	Adipose	gene expression	Ppp2r2a	0.09	0.06	6.2e-08	0.06	0.05	0.04	0.05	1.7e-07	1.9e-06	3.5e-05	2.2e-06
4	NAcc	gene expression	Ppp2r2a	0.02	0.02	7.3e-03	0.01	0.01	0.01	0.01	1.8e-03	5.3e-03	2.8e-02	5.3e-03
5	RMTg	gene expression	Ppp2r2a	0.14	0.1	8.3e-03	0	0.04	-0	0.02	2.7e-01	3.6e-02	3.9e-01	1.2e-01
6	NAcc	intron excision ratio	chr15_45437377_45439096	0.06	0.04	2.8e-07	0.04	0.04	0.03	0.04	5.8e-07	1.0e-06	5.6e-06	1.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.0	1.8	2.2	-1.0	-1.2	-1.4	-1.5	1.3	1.5
Area under the delay curve	0.0	0.0	0.2	-0.0	-0.0	0.2	0.2	-0.4	-0.1
BMI with tail	0.2	0.6	1.5	1.2	1.2	0.7	0.5	-0.2	-0.5
BMI without tail	0.1	0.5	1.1	1.0	1.1	-0.2	-0.3	0.8	0.2
Body weight	0.1	0.5	1.0	-0.2	0.2	0.9	0.8	-1.0	-0.8
Weight adjusted by age	0.4	1.3	2.8	0.4	0.6	1.2	1.2	-1.7	-1.2
Bone surface	0.7	1.4	2.0	-1.3	-1.4	-1.1	-1.2	0.7	1.2
Bone volume	0.7	1.4	2.2	-1.4	-1.5	-1.1	-1.1	0.7	1.1
Breakpoint value in progressive ratio session	0.2	0.4	0.6	0.8	0.2	0.7	0.7	-0.6	-0.7
Number of licking bursts	0.1	0.2	0.6	0.7	0.8	0.1	-0.1	0.3	0.1
Context. condit. distance diff. score	1.8	2.2	5.5	1.4	1.4	-1.1	-1.2	2.3	1.2
Locomotion velocity, session 1	0.1	0.2	0.4	-0.1	-0.2	0.4	0.5	-0.6	-0.5
Locomotion distance, session 1	0.6	0.8	2.2	-1.5	-1.5	-0.1	-0.0	-0.7	0.0
Locomotion velocity, session 2	0.4	0.5	0.9	-0.8	-0.9	0.4	0.4	-0.9	-0.4
Locomotion distance, session 2	0.8	1.2	3.2	-1.8	-1.7	-0.1	0.0	-0.8	-0.0
Locomotion velocity, session 3	0.9	1.0	1.7	1.3	1.3	0.9	1.0	-0.4	-1.0
Locomotion distance, session 3	0.4	0.4	1.4	0.9	1.2	0.1	0.0	0.4	-0.0
Stereotopy head waving bouts, day 3	0.7	0.9	1.3	0.4	-0.1	1.1	1.1	-1.2	-1.1
Stereotopy head waving duration, day 3	1.7	2.1	3.1	0.6	0.2	1.7	1.7	-1.8	-1.7
Locomotion velocity, session 7	4.2	4.6	11.6	0.4	0.8	-2.3	-2.2	3.4	2.2
Locomotion distance, session 7	4.4	5.6	12.4	-0.4	0.2	-2.7	-2.6	3.5	2.6
Stereotopy head waving bouts, day 7	1.2	1.4	2.9	0.2	0.1	1.4	1.4	-1.7	-1.4
Stereotopy head waving duration, day 7	2.1	2.6	3.8	0.9	0.6	1.9	1.9	-2.0	-1.9
Locomotion velocity, session 8	0.3	0.3	0.7	0.8	0.6	0.5	0.5	-0.0	-0.5
Locomotion distance, session 8	0.5	0.7	1.4	-0.4	-0.4	-0.9	-0.9	1.2	0.9
Degree of sensitization distance	5.6	6.1	10.2	-1.2	-1.1	-2.8	-2.8	3.2	2.8
Degree of sensitization stereotypy	0.9	1.0	1.6	0.4	0.4	1.2	1.1	-1.3	-1.1
Conditioned locomotion	0.4	0.5	1.6	1.1	1.3	0.1	0.2	0.5	-0.2
Cocaine response after cond. corrected	1.4	2.1	5.6	2.4	2.3	0.7	0.7	0.3	-0.7
Cocaine response after cond. not corrected	0.9	1.3	3.6	1.9	1.8	0.6	0.6	0.2	-0.6
Cocaine response before conditioning	1.2	1.4	3.6	-1.9	-1.8	-0.7	-0.7	-0.1	0.7
Saline control response	0.7	0.9	2.5	-1.6	-1.5	-0.6	-0.6	-0.1	0.6
Bone: connectivity density	1.6	2.5	3.3	-0.8	-1.1	-1.8	-1.8	1.8	1.8
Bone: cortical apparent density	0.2	0.3	0.9	0.7	0.5	-0.4	-0.3	1.0	0.3
Bone: cortical area	0.3	0.5	1.4	-1.2	-1.0	-0.4	-0.4	-0.1	0.4
Bone: cortical porosity	1.0	1.1	2.4	0.0	0.1	1.2	1.2	-1.5	-1.2
Bone: cortical porosity	0.8	0.8	2.1	-0.4	-0.4	1.0	0.9	-1.5	-0.9
Bone: cortical thickness	0.1	0.1	0.3	-0.6	-0.5	-0.1	-0.1	-0.1	0.1
Bone: cortical thickness	0.2	0.2	0.5	0.6	0.7	-0.1	0.0	0.5	-0.0
Bone: cortical tissue density	0.3	0.4	1.1	0.8	0.6	-0.4	-0.3	1.0	0.3
Condit. Reinf. active minus inactive responses	0.3	0.4	1.0	-0.4	-0.2	0.6	0.5	-1.0	-0.5
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.2	1.2	1.3	1.5	1.4	-1.2	-1.4
Condit. Reinf. active responses	0.5	0.7	2.0	-1.4	-1.2	-0.2	-0.2	-0.6	0.2
Condit. Reinf. inactive responses	3.8	4.9	9.4	-3.1	-2.9	-1.9	-1.9	0.7	1.9
Incentive salience index mean	0.6	0.8	2.1	-0.8	-0.7	0.8	0.7	-1.5	-0.7
Condit. Reinf. lever presses	0.6	0.9	1.8	-1.3	-1.3	0.5	0.4	-1.3	-0.4
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.6	0.4	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.4	0.7	0.5	0.3	0.3	-0.1	-0.3
Condit. Reinf. active responses	0.7	1.0	1.3	-1.0	-0.9	-1.1	-1.1	0.8	1.1
Condit. Reinf. inactive responses	1.6	2.3	2.9	-1.7	-1.3	-1.7	-1.6	1.2	1.6
Condit. Reinf. lever presses	0.5	0.7	2.0	-1.4	-1.4	-0.3	-0.4	-0.4	0.4
Condit. Reinf. lever reinforcers received	0.7	1.0	1.2	-1.1	-0.9	-1.1	-1.1	0.7	1.1
Conditioned reinforcement - actives	0.2	0.8	1.6	-0.3	-0.3	-1.0	-1.0	1.3	0.9
Conditioned reinforcement - inactives	1.2	3.4	4.0	-1.9	-1.8	-2.0	-2.0	1.4	1.9
Conditioned locomotion	0.1	0.1	0.5	0.2	0.3	-0.3	-0.3	0.7	0.1
Patch foraging indifference point 0 sec	2.4	6.7	16.1	-3.9	-4.0	-1.9	-1.7	0.3	1.6
Patch foraging indifference point AUC	0.7	1.6	3.4	1.8	1.8	1.0	1.1	-0.2	-1.1
Delay disc. indifference point, 0s delay	0.9	1.0	2.5	-1.5	-1.6	-0.7	-0.5	-0.2	0.5
Delay disc. indifference point, 16s delay	0.0	0.1	0.1	0.1	0.0	-0.1	-0.3	0.4	0.3
Delay disc. indifference point, 2s delay	0.6	0.7	2.3	-0.6	-0.3	0.8	0.7	-1.5	-0.6
Delay disc. indifference point, 24s delay	0.2	0.3	0.4	0.6	0.5	0.6	0.6	-0.3	-0.5
Delay disc. indifference point, 4s delay	1.1	1.1	1.4	0.9	0.9	1.1	1.1	-1.2	-1.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.0	-0.1	-0.4	-0.4	0.3	0.5
Indifference point function ln k	0.3	0.9	2.2	-1.5	-1.3	-0.7	-0.8	0.1	0.7
Indifference point function log k	0.3	0.9	2.2	-1.5	-1.3	-0.7	-0.8	0.1	0.7
Patch foraging total patch changes 0 sec	2.0	6.0	15.3	-3.8	-3.9	-1.6	-1.4	-0.0	1.4
Patch foraging total patch changes 12 sec	0.6	0.8	2.3	-1.5	-1.5	-0.5	-0.3	-0.2	0.3
Patch foraging total patch changes 18 sec	0.4	1.0	2.2	-1.3	-1.5	-1.0	-0.7	0.6	0.7
Patch foraging total patch changes 24 sec	0.2	0.8	2.4	-1.6	-1.4	-0.1	0.0	-0.8	0.0
Patch foraging total patch changes 6 sec	0.4	0.7	2.1	-1.3	-1.5	-0.5	-0.3	0.1	0.2
Patch foraging time to switch 0 sec	0.0	0.2	0.3	-0.1	-0.6	-0.4	-0.4	0.3	0.4
Patch foraging water rate 0 sec	0.1	0.3	0.8	-0.3	0.1	0.6	0.6	-0.9	-0.5
Patch foraging water rate 12 sec	0.1	0.3	0.8	-0.3	0.2	0.5	0.4	-0.9	-0.4
Patch foraging water rate 18 sec	0.7	1.6	1.9	0.9	1.3	1.4	1.4	-1.3	-1.3
Patch foraging water rate 24 sec	0.1	0.2	0.6	0.4	0.8	-0.2	-0.1	0.5	0.2
Patch foraging water rate 6 sec	1.0	1.5	3.3	0.0	0.3	1.3	1.5	-1.8	-1.4
Seeking ratio, delayed vs. immediate footshock	1.0	1.4	3.0	-1.7	-1.7	-0.7	-1.0	0.2	1.0
Distance traveled before self-admin	0.8	1.7	3.5	0.2	-0.2	1.5	1.4	-1.9	-1.4
Distance traveled after self-admin	1.3	2.2	3.2	1.0	0.7	1.7	1.7	-1.8	-1.7
Extensor digitorum longus weight	10.6	42.4	53.0	5.2	5.1	7.3	7.3	-6.5	-7.3
Bone: elastic displacement	0.6	0.7	2.0	-1.4	-1.4	-0.1	-0.1	-0.5	0.1
Bone: elastic work	1.5	1.9	5.6	-2.3	-2.4	-0.3	-0.2	-0.8	0.2
Bone: endosteal estimation	0.1	0.3	0.6	-0.8	-0.5	-0.4	-0.5	0.1	0.5
Bone: endosteal perimeter	0.2	0.6	1.7	-1.3	-1.0	-0.3	-0.4	-0.3	0.4
Epididymis fat weight	0.3	1.7	1.9	-1.3	-1.4	-1.4	-1.3	1.2	1.3
Delta time in closed arm before/after self-admin	2.1	1.9	2.1	-1.3	-1.4	-1.5	-1.4	1.3	1.4
Delta time in open arm before/after self-admin	0.1	0.2	0.4	0.4	0.7	0.4	0.3	-0.4	-0.3
Diff in mean of infusions in LGA sessions	0.3	0.5	1.0	-0.1	-0.4	0.8	0.8	-1.0	-0.8
Delay discount exponential model param	0.2	0.2	0.5	-0.2	-0.2	-0.6	-0.5	0.7	0.4
Extinction: sum of active levers before priming	1.1	1.7	2.6	-1.2	-1.6	-1.3	-1.4	1.0	1.3
Active lever presses in extinction session 6	0.5	0.5	1.3	0.4	0.1	-0.7	-0.7	1.1	0.6
Bone: final force	0.1	0.1	0.3	-0.5	-0.6	-0.0	-0.1	-0.3	0.1
Bone: final moment	0.3	0.4	1.2	-1.1	-1.1	-0.2	-0.2	-0.3	0.2
Food consumed during 24 hour testing period	0.6	1.3	2.4	-1.6	-1.3	-1.0	-1.1	0.5	1.1
Glucose	0.3	0.5	1.1	0.9	1.0	-0.2	-0.2	0.8	0.2
Heart weight	1.1	1.8	2.5	-1.0	-0.8	-1.5	-1.6	1.4	1.5
Delay discount hyperbolic model param	0.2	0.3	0.8	-0.2	-0.2	-0.6	-0.6	0.9	0.5
Intermittent access intake day 1-15 change	0.2	1.2	2.0	-0.6	-0.7	-1.3	-1.2	1.4	1.0
Intermittent access intake escalation	0.2	1.1	1.7	-0.7	-0.8	-1.3	-1.2	1.3	0.9
Intermittent access intake escalation 2	0.4	0.7	1.2	-0.4	-0.3	-1.0	-1.0	1.1	0.8
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	0.5	0.4	-0.2	-0.2	0.5	0.4
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.7	0.6	0.8	-0.4	-0.3	0.7	0.3
Intermitt. access escalation Index	0.0	0.0	0.2	-0.2	-0.0	-0.1	-0.1	-0.0	0.4
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.2	-0.0	0.1
Intermittent access day 15 total infusions	0.4	1.0	1.7	-0.5	-0.6	-1.2	-1.1	1.3	0.9
Intermittent access terminal intake (last 3 days)	0.2	0.4	1.1	0.1	-0.0	-0.8	-0.7	1.1	0.5
Intermittent access total infusions	0.7	0.8	1.6	-0.2	-0.5	-1.1	-1.0	1.3	0.8
Intermittent access day 1 locomotion	0.2	0.4	1.1	-1.0	-1.0	-0.4	-0.5	-0.0	0.4
Intermittent access day 15 total locomotion	0.1	0.2	0.6	0.1	0.2	-0.5	-0.5	0.8	0.3
Intermittent access total locomotion	0.1	0.1	0.3	-0.5	-0.4	-0.4	-0.4	0.3	0.2
Intermittent access standard deviation	0.0	0.0	0.1	0.2	0.1	-0.1	-0.0	0.3	0.1
Left kidney weight	0.1	0.5	1.7	-1.3	-0.8	-0.4	-0.5	-0.2	0.6
Right kidney weight	0.3	2.0	6.3	-2.5	-2.0	-0.6	-0.6	-0.5	0.7
Cocaine induced anxiety	0.4	1.0	2.5	-1.6	-1.6	0.2	0.2	-1.1	-0.2
Post-drug Anxiety	2.1	2.4	5.8	-2.4	-2.3	-1.0	-1.2	0.0	1.2
Baseline Anxiety	0.7	1.1	1.8	-0.3	0.0	-1.2	-1.3	1.3	1.3
Tail length	0.5	2.8	5.7	-2.4	-1.9	-1.5	-1.5	0.9	1.5
Length with tail	0.3	1.2	4.7	-2.2	-1.5	-0.1	-0.2	-0.7	0.2
Length without tail	0.6	3.1	6.6	0.0	0.6	2.1	1.9	-2.6	-1.9
Times rat made contact with spout	0.9	1.1	1.6	-0.5	-0.3	-1.2	-1.3	1.3	1.3
Lifetime Intake	0.4	0.5	1.0	-0.3	-0.5	-0.8	-0.8	1.0	0.7
Liver weight, left	0.6	1.1	2.7	-0.2	0.1	1.2	1.1	-1.6	-1.0
Liver weight, right	0.9	1.6	2.6	1.6	1.6	1.3	1.1	-0.7	-1.1
Locomotor activity	1.9	2.9	6.8	-1.6	-1.6	1.4	1.3	-2.6	-1.3
Locomotor testing distance	1.4	3.4	9.6	-3.0	-3.1	-0.4	-0.4	-1.1	0.4
Locomotor testing rearing	1.3	4.7	13.3	-3.6	-3.5	-0.7	-0.7	-1.0	0.6
Locomotion in novel chamber	0.3	0.5	1.0	-0.2	0.0	-0.7	-1.0	0.6	1.0
Locomotion in novel chamber post-restriction	0.3	0.8	1.3	0.9	0.6	1.1	0.9	-0.9	-0.9
Fecal boli incidents, locomotor time 1	0.0	0.1	0.3	0.1	0.0	0.3	0.2	-0.5	-0.2
Change in fecal boli incidents, locomotor task	0.9	0.9	1.5	1.2	1.2	1.1	0.8	-0.5	-0.8
Time >=10cm from walls, locomotor time 1	1.2	1.5	2.0	-1.2	-1.2	-1.2	-1.4	0.8	1.4
Bouts of movement, locomotor time 1	2.5	3.2	4.5	1.9	2.1	1.8	1.8	-1.4	-1.7
Total resting periods, locomotor time 1	3.3	3.8	6.5	2.4	2.5	1.8	1.8	-1.1	-1.8
Rest time, locomotor task time 1	1.6	2.6	6.0	2.3	2.5	1.1	1.2	-0.3	-1.2
Distance moved, locomotor task time 1	0.7	1.8	3.3	-1.8	-1.6	-1.3	-1.2	0.8	1.3
Vertical activity count, locomotor time 1	0.2	1.1	2.7	-1.6	-1.6	0.3	0.3	-1.2	-0.2
Time >=10cm from walls, locomotor time 2	0.1	0.4	0.8	0.9	0.7	0.7	0.6	-0.4	-0.5
Bouts of movement, locomotor time 2	1.2	3.9	5.0	2.2	2.2	2.0	2.0	-1.3	-2.0
Total resting periods, locomotor time 2	1.2	4.7	6.5	2.6	2.5	2.1	2.2	-1.2	-2.1
Rest time, locomotor task time 2	1.4	2.4	5.1	2.3	2.2	1.1	1.3	-0.1	-1.3
Distance moved, locomotor task time 2	2.2	2.9	4.8	-2.2	-2.1	-1.5	-1.6	0.7	1.7
Vertical activity count, locomotor time 2	0.4	1.0	3.1	-1.5	-1.8	0.1	0.1	-1.0	-0.1
Light reinforcement 1	0.9	4.1	5.6	-1.2	-1.1	-2.3	-2.4	2.4	2.3
Light reinforcement 2	0.6	1.2	3.4	0.7	0.4	-1.0	-1.1	1.8	1.1
Bone: marrow area	0.2	0.4	0.8	-0.9	-0.6	-0.6	-0.6	0.2	0.6
Bone: maximum diameter	0.1	0.1	0.2	-0.1	0.1	0.4	0.4	-0.5	-0.4
Bone: maximum force	0.2	0.3	0.7	-0.7	-0.7	0.4	0.3	-0.8	-0.3
Bone: maximum moment	0.4	0.7	1.8	-1.3	-1.3	0.1	0.1	-0.8	-0.1
Mean time between licks in bursts	0.4	2.3	2.6	-1.5	-1.5	-1.6	-1.6	1.2	1.6
Mean num. licks in bursts	0.2	0.7	0.9	-1.0	-0.9	-0.9	-0.7	0.6	0.7
Cd content in liver	1.3	1.5	3.3	-0.2	-0.4	1.3	1.3	-1.8	-1.3
Co content in liver	3.9	4.5	5.5	2.3	2.3	2.2	2.1	-1.6	-2.1
Cu content in liver	0.7	0.8	1.2	1.1	1.0	0.8	0.8	-0.5	-0.8
Fe content in liver	1.7	2.1	2.7	-1.2	-1.1	-1.7	-1.6	1.4	1.6
K content in liver	0.8	0.8	1.6	0.2	0.3	-0.9	-1.0	1.3	1.0
Mg content in liver	1.4	1.6	2.2	-0.7	-0.6	-1.4	-1.5	1.5	1.5
Mn content in liver	2.1	2.3	2.6	-1.5	-1.5	-1.6	-1.6	1.2	1.6
Na content in liver	1.2	1.3	3.3	-0.3	-0.4	1.2	1.2	-1.8	-1.2
Rb content in liver	0.1	0.1	0.2	0.1	0.3	-0.3	-0.3	0.4	0.3
Se content in liver	1.8	2.1	6.1	-2.3	-2.5	-0.7	-0.7	-0.4	0.7
Sr content in liver	0.0	0.0	0.1	-0.2	-0.3	0.0	0.0	-0.2	-0.0
Zn content in liver	0.3	0.3	0.7	-0.8	-0.9	-0.4	-0.4	-0.0	0.4
Bone: minimum diameter	0.3	0.6	1.7	-1.3	-1.1	-0.1	-0.1	-0.7	0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.2	0.4	-0.3	-0.3	0.5	0.3
Time in novel zone, hab. session 1	1.4	1.5	1.8	1.3	1.2	1.3	1.3	-1.0	-1.3
Total zone transitions, hab. session 1	0.2	0.2	0.5	-0.7	-0.7	0.2	0.2	-0.5	-0.2
Total locomotion distance, hab. session 1	0.4	0.6	1.9	-1.4	-1.2	-0.3	-0.3	-0.3	0.3
Locomotion velocity, hab. session 1	1.1	1.5	4.4	-2.1	-1.9	-0.6	-0.6	-0.3	0.6
Time in familiar zone, hab. session 2	1.7	1.9	4.9	2.0	2.2	0.9	0.9	-0.1	-0.9
Time in novel zone, hab. session 2	0.7	0.8	2.3	-1.3	-1.5	-0.5	-0.4	-0.2	0.4
Total zone transitions, hab. session 2	1.2	1.5	3.3	-0.1	-0.1	1.3	1.4	-1.8	-1.4
Total locomotion distance, hab. session 2	0.3	0.4	1.0	-0.3	-0.2	0.6	0.7	-1.0	-0.7
Locomotion velocity, hab. session 2	0.6	0.8	1.9	-0.3	-0.1	0.9	1.0	-1.4	-1.0
Novel to familiar place preference ratio	0.4	0.5	1.5	-0.9	-1.2	-0.5	-0.5	0.0	0.5
Novelty place preference	0.3	0.4	1.3	-0.9	-1.1	-0.4	-0.4	-0.1	0.4
Time in novel zone, NPP test	0.2	0.3	0.9	-0.7	-0.9	-0.1	-0.1	-0.4	0.1
Total zone transitions, NPP test	0.5	0.7	2.0	-1.4	-1.3	-0.5	-0.4	-0.0	0.4
Total locomotion distance, NPP test	3.0	4.1	7.0	-2.6	-2.4	-1.9	-1.9	1.1	1.9
Locomotion velocity, NPP test	2.8	4.0	6.2	-2.5	-2.2	-2.0	-1.9	1.2	1.9
Intraocular pressure	0.5	0.8	1.4	-1.2	-1.2	-0.9	-0.7	0.5	0.7
Delta distance traveled before/after self-admin	1.4	1.5	2.3	1.5	1.5	1.2	1.1	-0.7	-1.1
Delta ambulatory time before/after self-admin	0.9	1.5	1.7	1.3	1.2	1.3	1.3	-0.9	-1.3
Parametrial fat weight	2.1	5.0	5.6	-2.1	-2.0	-2.3	-2.4	2.2	2.3
Pavlov. Cond. lever latency	0.2	0.3	0.9	1.0	0.7	0.1	0.1	0.4	-0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	-0.8	-0.5	-0.7	-0.7	0.5	0.7
Pavlov. Cond. change in total contacts	1.0	1.0	2.7	-0.6	-0.5	1.0	1.0	-1.6	-1.0
Pavlov. Cond. index score	0.2	0.2	0.8	-0.9	-0.5	-0.0	-0.1	-0.4	0.1
Pavlov. Cond. latency score	0.2	0.3	1.1	-1.0	-0.7	-0.2	-0.2	-0.3	0.2
Pavlov. Cond. lever contacts	0.3	0.3	1.1	-1.0	-0.7	-0.3	-0.3	-0.2	0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	0.2	-0.1	-0.1	0.4	0.1
Pavlov. Cond. intertrial magazine entries	0.7	0.8	2.2	-1.4	-1.5	-0.4	-0.4	-0.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	-0.8	-0.5	0.1	0.1	-0.5	-0.1
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.4	-0.2	0.1	0.1	-0.3	-0.1
Pavlov. Cond. lever latency	0.8	1.1	2.9	0.6	0.7	-1.1	-1.0	1.7	1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	1.4	-1.2	-1.1	-0.3	-0.4	-0.2	0.4
Pavlov. Cond. change in total contacts	0.7	1.7	3.7	0.0	-0.0	1.5	1.4	-1.9	-1.4
Pavlov. Cond. index score	0.5	0.8	2.1	-0.7	-0.7	0.8	0.7	-1.5	-0.7
Pavlov. Cond. latency score	0.5	0.8	1.7	-1.0	-1.0	0.6	0.5	-1.3	-0.5
Pavlov. Cond. lever contacts	0.6	1.0	2.2	-0.9	-1.0	0.8	0.7	-1.5	-0.7
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	1.0	0.9	0.2	0.3	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	3.1	6.7	8.2	-2.2	-2.3	-2.9	-2.8	2.5	2.8
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	2.1	-0.5	-0.6	0.9	0.8	-1.5	-0.8
Pavlov. Cond. response bias	0.7	1.0	2.4	-0.9	-0.9	0.8	0.8	-1.6	-0.8
Time in closed arm before self-admin	0.5	0.8	1.2	0.8	0.7	1.1	1.0	-0.8	-0.9
Time in closed arm after self-admin	0.1	0.1	0.3	-0.6	-0.6	-0.1	-0.2	0.1	0.2
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	-0.5	-0.1	-0.1	-0.0	0.1
Time in open arm after self-admin	0.1	0.1	0.3	0.4	0.5	0.0	0.1	-0.1	-0.1
Bone: periosteal estimation	0.2	0.5	1.3	-1.2	-0.8	-0.5	-0.5	0.0	0.5
Bone: periosteal perimeter	0.2	0.4	1.1	-1.1	-0.8	-0.4	-0.4	-0.2	0.4
Bone: post-yield work	0.3	0.5	1.1	0.7	0.7	-0.5	-0.5	1.1	0.5
Progressive ratio test 1 active lever presses	0.1	0.2	0.8	0.9	0.5	-0.0	-0.1	0.5	0.1
Progressive ratio test 1 breakpoint	0.1	0.2	0.9	0.9	0.5	0.0	-0.0	0.4	0.0
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.7	0.1	-0.1	-1.0	-1.0	1.3	1.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.1	-0.4	-0.5	-0.3	0.5	0.2
Progressive ratio test 2 breakpoint	0.1	0.2	0.3	-0.3	-0.5	-0.5	-0.3	0.5	0.2
Progressive ratio test 2 inactive lever presses	0.2	0.8	1.3	-0.4	-0.3	-1.1	-1.0	1.2	0.9
Incentive Sensitization - Responses	0.3	0.7	2.0	-1.3	-1.4	-0.6	-0.5	0.1	0.3
Incentive Sensitization - Breakpoint	0.4	0.9	2.3	-1.4	-1.5	-0.7	-0.6	0.1	0.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	0.8	0.5	-0.4	-0.4	0.9	0.4
Progressive ratio	0.2	0.7	1.1	0.5	0.6	1.0	0.9	-1.0	-0.9
Food seeking constrained by brief footshock	3.4	4.3	9.5	3.1	2.8	1.6	1.8	-0.3	-1.8
Seeking ratio, punishment vs. effort	0.3	0.6	2.0	1.4	1.1	0.2	0.3	0.4	-0.4
Retroperitoneal fat weight	0.3	1.5	2.4	-0.8	-0.5	-1.3	-1.5	1.4	1.5
Reaction time number correct	0.2	0.8	2.2	1.3	1.5	0.6	0.7	-0.1	-0.6
Reaction time mean minus median	0.0	0.3	0.7	0.1	-0.1	0.6	0.6	-0.8	-0.6
Reaction time mean minus median AUC	0.0	0.1	0.2	0.3	0.3	0.3	0.3	-0.4	-0.2
Reaction time num false alarms	0.1	0.2	0.5	-0.5	-0.7	-0.2	-0.3	-0.1	0.2
Reaction time num false alarms AUC	0.1	0.1	0.5	-0.5	-0.7	-0.2	-0.3	-0.1	0.2
Reaction time trials correct on left	0.2	0.8	2.2	1.3	1.5	0.6	0.7	-0.1	-0.6
Reaction time trials on left	0.2	0.7	1.9	1.2	1.4	0.5	0.6	0.0	-0.5
Reaction time mean	0.1	0.3	0.4	0.3	0.3	0.6	0.6	-0.6	-0.5
Reaction time mean AUC	0.2	0.5	0.8	0.4	0.4	0.8	0.8	-0.9	-0.8
Median of all reaction times	0.1	0.2	0.3	0.4	0.4	0.5	0.5	-0.5	-0.5
Reaction time omissions	0.7	1.2	1.6	-0.8	-0.9	-1.3	-1.1	1.2	1.2
Reaction time false alarm rate	0.4	0.5	1.4	-0.9	-1.2	-0.6	-0.6	0.2	0.6
Reaction time premature initiation rate	1.2	1.8	2.1	1.3	1.4	1.4	1.5	-1.0	-1.4
Reaction time premature initiations	0.9	2.9	4.6	2.0	2.2	1.6	1.7	-1.0	-1.6
Std. dev. reaction times	0.1	0.2	0.3	0.4	0.2	0.5	0.5	-0.6	-0.5
Reaction time trials completed	0.2	0.7	1.9	1.2	1.4	0.5	0.6	0.0	-0.5
Reaction time trials AUC	0.2	0.6	1.6	1.1	1.3	0.5	0.6	-0.0	-0.5
Run reversals in cocaine runway, females	1.4	1.6	2.5	-1.0	-1.2	-1.6	-1.3	1.2	1.3
Run reversals in cocaine runway, males	2.6	2.8	3.8	1.3	1.1	1.8	1.9	-1.8	-1.9
Latency to leave start box in cocaine runway	1.4	2.0	3.0	1.7	1.6	1.4	1.2	-1.1	-1.2
Latency to leave start box in cocaine runway, F	2.7	3.4	4.1	1.9	2.0	1.9	1.8	-1.6	-1.8
Latency to leave start box in cocaine runway, M	0.0	0.0	0.2	0.4	-0.1	0.1	0.0	-0.1	-0.0
Std. dev. time between licks in bursts	2.2	4.1	9.1	-2.9	-3.0	-1.6	-1.5	0.5	1.5
Total sessions with >9 infusions	0.0	0.0	0.1	0.2	0.1	0.1	0.1	0.1	0.1
Short access day 1 total inactive lever presses	0.2	0.3	1.0	-0.7	-1.0	-0.4	-0.4	0.1	0.2
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.1	0.1	-0.4	-0.4	0.4	0.5
Short access day 1 total infusions	0.1	0.1	0.2	0.4	0.1	0.4	0.4	-0.1	-0.4
Short access day 10 total infusions	0.2	0.3	0.8	-0.2	-0.4	0.6	0.6	-0.9	-0.6
Short access total infusions	0.1	0.1	0.2	-0.2	-0.5	0.2	0.2	-0.3	-0.2
Short access day 1 locomotion	0.3	0.5	1.1	-0.2	-0.2	0.7	0.8	-1.0	-0.7
Short access day 10 total locomotion	0.1	0.3	0.8	-0.9	-0.9	-0.2	-0.3	-0.2	0.4
Short access total locomotion	0.2	0.2	0.6	-0.7	-0.8	0.2	0.2	-0.6	-0.0
One hour access (0.3 mA shock)	0.6	0.7	0.9	-0.8	-0.8	-0.9	-0.9	0.7	0.7
Compulsive drug intake	0.5	0.8	1.0	-1.0	-1.0	-0.9	-1.0	0.5	0.9
One hour access (shock baseline)	0.0	0.0	0.0	0.0	0.1	-0.0	0.1	0.1	-0.2
Social response proportion	0.7	0.9	2.7	1.4	1.6	0.0	-0.1	0.8	0.2
Social responses	2.9	3.8	5.7	-1.0	-0.3	-2.2	-2.3	2.4	2.4
Social time	0.7	1.1	2.3	-1.5	-0.8	-1.0	-1.1	0.3	1.1
Soleus weight	1.2	3.5	4.3	2.1	2.0	1.9	1.9	-1.3	-1.9
Bone: stiffness	0.1	0.3	0.3	0.4	0.5	0.6	0.5	-0.6	-0.5
Tibialis anterior weight	6.7	23.2	29.5	3.6	3.5	5.4	5.4	-5.0	-5.4
Time to tail flick, vehicle, before self-admin	0.7	0.9	1.2	-0.8	-0.6	-1.0	-1.1	0.9	1.1
Time to tail flick, vehicle, after self-admin	2.9	5.8	9.7	3.1	3.1	2.3	2.1	-1.2	-2.1
Time to tail flick, test, before self-admin	3.5	4.0	5.1	-2.0	-2.3	-2.1	-2.0	1.6	2.0
Time to tail flick, test, after self-admin	2.7	2.9	6.5	-0.2	-0.0	-1.8	-1.9	2.5	1.9
Delta time to tail flick, vehicle, before/after SA	1.7	1.8	4.4	2.1	2.0	0.9	0.9	0.0	-0.9
Delta time to tail flick, test, before/after SA	1.1	1.4	3.7	1.7	1.9	-0.2	-0.3	1.4	0.4
Tibia length	2.6	7.3	17.1	-4.1	-4.1	-1.8	-1.8	0.2	1.8
Ambulatory time before self-admin	0.2	0.5	1.4	-0.2	-0.2	0.8	0.7	-1.2	-0.7
Ambulatory time after self-admin	2.5	4.0	5.9	1.3	1.1	2.4	2.2	-2.4	-2.2
Bone: tissue strength	0.3	0.3	0.8	-0.8	-0.9	-0.4	-0.4	0.1	0.4
Total heroin consumption	1.1	1.3	1.9	0.7	0.2	1.3	1.4	-1.3	-1.4
Bone: trabecular number	1.4	2.6	3.2	-1.3	-1.5	-1.7	-1.8	1.5	1.8
Bone: trabecular spacing	1.7	2.5	3.4	1.1	1.1	1.8	1.8	-1.6	-1.8
Bone: trabecular thickness	0.9	1.2	1.8	-1.2	-1.3	-1.1	-1.1	0.7	1.1
Bone: trabecular tissue density	0.9	1.5	2.2	0.7	0.5	1.4	1.4	-1.5	-1.4
Water consumed over 24 hours	0.3	0.6	1.0	0.3	0.5	0.9	0.9	-1.0	-0.9
Number of responses in last shaping day	0.6	0.7	1.3	0.4	0.2	1.1	1.0	-1.1	-0.9