Hub : Genes

Spink4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA intron excision ratio chr5_60778104_60854635 0.03 0.03 9.1e-03 0.02 0.02 0.02 0.02 5.7e-03 4.3e-03 6.7e-03 5.9e-03
2 Eye intron excision ratio chr5_60778104_60782021 0.33 0.17 2.3e-03 0.21 0.17 0.22 0.2 3.5e-04 1.2e-03 3.2e-04 5.5e-04
3 BLA alternative TSS XM_063288150.1 0.08 0.06 2.5e-03 0.04 0.02 0.03 0.03 2.9e-03 1.9e-02 9.5e-03 9.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.11.82.4-1.51.5-0.9
Area under the delay curve0.40.40.80.9-0.50.5
BMI with tail0.61.93.5-1.91.5-0.4
BMI without tail0.72.24.5-2.11.4-0.1
Body weight1.56.510.8-3.32.71.2
Weight adjusted by age0.40.61.5-0.40.51.2
Bone surface0.50.81.4-1.21.00.1
Bone volume0.50.91.3-1.11.1-0.4
Breakpoint value in progressive ratio session2.53.05.41.2-1.52.3
Number of licking bursts4.37.011.3-3.13.4-0.5
Context. condit. distance diff. score0.10.10.20.4-0.1-0.4
Locomotion velocity, session 14.04.312.7-0.3-0.13.6
Locomotion distance, session 11.11.44.1-0.30.12.0
Locomotion velocity, session 21.51.82.7-1.61.6-0.4
Locomotion distance, session 21.62.22.5-1.61.41.4
Locomotion velocity, session 30.70.82.5-0.0-0.01.6
Locomotion distance, session 31.11.21.7-1.00.81.3
Stereotopy head waving bouts, day 30.40.51.2-0.40.31.1
Stereotopy head waving duration, day 30.10.20.2-0.40.50.2
Locomotion velocity, session 70.00.10.10.4-0.10.0
Locomotion distance, session 70.20.30.6-0.30.50.8
Stereotopy head waving bouts, day 71.71.93.1-1.81.60.4
Stereotopy head waving duration, day 71.31.62.5-1.61.50.1
Locomotion velocity, session 80.80.92.5-0.30.51.6
Locomotion distance, session 80.50.71.8-0.30.41.3
Degree of sensitization distance0.30.30.50.7-0.4-0.5
Degree of sensitization stereotypy1.51.62.7-1.61.50.0
Conditioned locomotion0.50.61.50.1-0.51.2
Cocaine response after cond. corrected1.11.32.40.9-0.91.5
Cocaine response after cond. not corrected1.21.43.40.7-0.61.8
Cocaine response before conditioning0.91.11.7-1.21.3-0.0
Saline control response1.72.32.9-1.71.51.4
Bone: connectivity density0.50.80.8-0.80.9-0.9
Bone: cortical apparent density0.40.61.6-0.10.3-1.3
Bone: cortical area2.53.95.1-2.32.3-1.2
Bone: cortical porosity0.10.10.20.10.3-0.5
Bone: cortical porosity0.20.20.4-0.40.60.0
Bone: cortical thickness1.83.13.5-1.51.8-1.9
Bone: cortical thickness0.40.51.40.10.3-1.2
Bone: cortical tissue density0.30.51.3-0.00.2-1.2
Condit. Reinf. active minus inactive responses0.20.20.5-0.70.50.1
Condit. Reinf. active-inactive response ratio0.70.81.21.0-1.1-0.4
Condit. Reinf. active responses1.72.03.5-1.91.60.2
Condit. Reinf. inactive responses2.53.14.7-2.12.2-0.2
Incentive salience index mean2.63.25.2-2.32.00.8
Condit. Reinf. lever presses7.610.715.6-3.93.61.8
Condit. Reinf. active minus inactive responses0.30.40.6-0.80.7-0.4
Condit. Reinf. active-inactive response ratio0.20.20.5-0.10.2-0.7
Condit. Reinf. active responses0.91.32.3-1.51.3-0.2
Condit. Reinf. inactive responses1.52.03.3-1.81.5-0.6
Condit. Reinf. lever presses1.42.02.9-1.71.4-1.1
Condit. Reinf. lever reinforcers received1.11.52.7-1.71.4-0.1
Conditioned reinforcement - actives0.10.10.2-0.50.3-0.3
Conditioned reinforcement - inactives0.00.00.1-0.10.00.2
Conditioned locomotion0.00.10.1-0.2-0.30.1
Patch foraging indifference point 0 sec1.52.98.2-0.30.52.9
Patch foraging indifference point AUC2.63.86.9-2.62.00.7
Delay disc. indifference point, 0s delay0.20.20.50.7-0.10.5
Delay disc. indifference point, 16s delay1.31.51.61.2-1.11.3
Delay disc. indifference point, 2s delay0.30.40.5-0.50.5-0.7
Delay disc. indifference point, 24s delay0.10.10.40.6-0.10.0
Delay disc. indifference point, 4s delay0.10.10.20.4-0.1-0.1
Delay disc. indifference point, 8s delay0.00.00.00.10.2-0.0
Indifference point function ln k0.71.22.51.6-1.10.1
Indifference point function log k0.71.22.51.6-1.10.1
Patch foraging total patch changes 0 sec1.63.17.2-0.91.12.7
Patch foraging total patch changes 12 sec0.70.91.3-1.11.10.5
Patch foraging total patch changes 18 sec0.20.30.8-0.30.00.9
Patch foraging total patch changes 24 sec1.01.82.3-1.51.31.1
Patch foraging total patch changes 6 sec1.92.84.7-1.51.32.2
Patch foraging time to switch 0 sec1.53.13.82.0-1.9-1.4
Patch foraging water rate 0 sec1.12.32.7-1.41.51.7
Patch foraging water rate 12 sec0.10.30.5-0.40.30.7
Patch foraging water rate 18 sec0.91.41.8-1.01.3-1.1
Patch foraging water rate 24 sec0.50.71.1-0.40.9-1.1
Patch foraging water rate 6 sec1.32.03.2-1.81.60.2
Seeking ratio, delayed vs. immediate footshock1.11.42.7-1.71.20.2
Distance traveled before self-admin3.95.28.3-2.92.41.1
Distance traveled after self-admin4.35.28.2-2.62.9-0.8
Extensor digitorum longus weight3.614.022.7-4.84.40.3
Bone: elastic displacement4.85.68.93.0-2.6-1.1
Bone: elastic work3.14.18.01.7-1.1-2.8
Bone: endosteal estimation0.61.31.7-1.30.71.3
Bone: endosteal perimeter0.71.51.9-1.40.91.4
Epididymis fat weight0.20.51.0-0.81.0-0.2
Delta time in closed arm before/after self-admin0.30.20.6-0.1-0.3-0.8
Delta time in open arm before/after self-admin0.10.10.30.3-0.20.5
Diff in mean of infusions in LGA sessions0.50.61.00.5-0.8-1.0
Delay discount exponential model param0.40.40.8-0.90.5-0.4
Extinction: sum of active levers before priming1.11.22.41.5-1.10.2
Active lever presses in extinction session 60.10.10.20.40.0-0.1
Bone: final force1.42.33.9-2.01.7-0.3
Bone: final moment1.22.03.1-1.81.5-0.6
Food consumed during 24 hour testing period0.91.21.6-1.31.11.0
Glucose1.01.52.2-1.51.40.6
Heart weight0.20.30.5-0.70.6-0.0
Delay discount hyperbolic model param0.30.30.6-0.80.5-0.5
Intermittent access intake day 1-15 change0.10.20.4-0.6-0.0-0.2
Intermittent access intake escalation0.10.20.5-0.70.1-0.5
Intermittent access intake escalation 21.21.41.6-1.31.0-1.2
Intermitt. access day 1 inactive lever presses0.20.91.2-0.81.10.9
Intermitt. access day 15 inactive lever presses0.10.20.3-0.60.20.4
Intermitt. access escalation Index0.10.20.3-0.40.50.1
Intermittent access day 1 total infusions1.32.13.61.6-1.90.3
Intermittent access day 15 total infusions0.20.30.50.1-0.7-0.7
Intermittent access terminal intake (last 3 days)0.10.20.4-0.60.3-0.4
Intermittent access total infusions0.10.10.2-0.0-0.4-0.0
Intermittent access day 1 locomotion1.21.52.21.5-1.50.3
Intermittent access day 15 total locomotion1.52.64.91.7-2.20.2
Intermittent access total locomotion1.31.62.51.3-1.6-0.7
Intermittent access standard deviation0.00.10.1-0.3-0.20.3
Left kidney weight0.62.64.1-1.61.12.0
Right kidney weight0.10.71.1-1.10.70.6
Cocaine induced anxiety0.81.12.2-1.01.50.3
Post-drug Anxiety2.72.94.5-1.82.10.9
Baseline Anxiety0.30.40.6-0.70.7-0.2
Tail length1.03.86.6-2.62.10.5
Length with tail1.04.55.2-2.32.12.0
Length without tail0.31.02.7-0.30.31.6
Times rat made contact with spout0.50.60.7-0.80.8-0.6
Lifetime Intake0.10.10.2-0.1-0.40.4
Liver weight, left0.10.20.4-0.30.40.6
Liver weight, right0.61.01.41.1-1.2-0.7
Locomotor activity0.00.00.10.2-0.1-0.0
Locomotor testing distance0.20.40.90.5-0.30.9
Locomotor testing rearing0.20.50.8-0.90.50.6
Locomotion in novel chamber0.50.71.7-0.31.3-0.6
Locomotion in novel chamber post-restriction1.42.22.6-1.61.6-1.3
Fecal boli incidents, locomotor time 11.52.23.41.8-1.8-0.3
Change in fecal boli incidents, locomotor task0.60.50.9-0.90.50.7
Time >=10cm from walls, locomotor time 10.10.10.4-0.0-0.20.6
Bouts of movement, locomotor time 10.50.61.11.0-0.7-0.5
Total resting periods, locomotor time 11.21.42.01.4-1.0-1.0
Rest time, locomotor task time 11.72.24.81.0-0.8-2.2
Distance moved, locomotor task time 11.32.03.8-1.30.81.9
Vertical activity count, locomotor time 10.92.24.3-1.11.02.1
Time >=10cm from walls, locomotor time 20.10.10.3-0.2-0.10.6
Bouts of movement, locomotor time 20.40.71.3-0.91.1-0.2
Total resting periods, locomotor time 20.20.30.6-0.50.8-0.3
Rest time, locomotor task time 20.50.70.80.8-0.7-0.9
Distance moved, locomotor task time 20.10.10.2-0.50.2-0.2
Vertical activity count, locomotor time 20.40.50.6-0.70.60.8
Light reinforcement 11.23.17.6-1.10.52.8
Light reinforcement 21.62.57.1-0.60.32.7
Bone: marrow area0.51.11.8-1.40.71.0
Bone: maximum diameter1.93.65.6-2.42.3-0.4
Bone: maximum force2.84.98.1-2.92.5-0.3
Bone: maximum moment2.34.06.4-2.52.3-0.6
Mean time between licks in bursts0.30.71.30.9-1.2-0.1
Mean num. licks in bursts2.43.86.32.2-2.5-0.2
Cd content in liver1.01.11.8-1.31.2-0.2
Co content in liver0.70.81.10.8-0.81.1
Cu content in liver0.60.71.31.1-0.7-0.5
Fe content in liver1.01.21.31.0-1.11.1
K content in liver0.30.30.40.5-0.50.7
Mg content in liver0.80.81.41.2-1.10.0
Mn content in liver2.12.33.1-1.71.8-0.9
Na content in liver0.80.91.21.1-1.0-0.7
Rb content in liver4.24.97.42.7-2.7-0.1
Se content in liver3.03.65.8-2.12.4-0.7
Sr content in liver0.50.40.6-0.80.8-0.3
Zn content in liver0.10.20.2-0.10.5-0.4
Bone: minimum diameter0.10.20.40.3-0.5-0.6
Time in familiar zone, hab. session 12.72.67.80.30.2-2.8
Time in novel zone, hab. session 13.63.66.11.4-1.72.5
Total zone transitions, hab. session 10.00.00.00.20.20.1
Total locomotion distance, hab. session 11.11.62.1-0.81.4-1.4
Locomotion velocity, hab. session 11.92.74.2-1.62.1-1.1
Time in familiar zone, hab. session 21.61.73.70.9-0.7-1.9
Time in novel zone, hab. session 21.71.73.60.8-1.01.9
Total zone transitions, hab. session 20.91.22.4-0.80.71.5
Total locomotion distance, hab. session 20.91.22.0-1.21.40.2
Locomotion velocity, hab. session 21.01.32.3-1.31.50.1
Novel to familiar place preference ratio3.74.16.32.1-2.51.2
Novelty place preference4.44.77.42.4-2.70.9
Time in novel zone, NPP test5.25.68.72.6-2.91.0
Total zone transitions, NPP test0.81.12.0-0.90.81.4
Total locomotion distance, NPP test1.52.12.5-1.61.51.1
Locomotion velocity, NPP test1.62.33.2-1.81.70.9
Intraocular pressure1.01.52.3-1.51.30.6
Delta distance traveled before/after self-admin0.20.20.4-0.20.4-0.6
Delta ambulatory time before/after self-admin0.20.20.50.10.4-0.7
Parametrial fat weight0.30.71.30.6-0.61.2
Pavlov. Cond. lever latency5.77.110.93.3-3.0-1.2
Pavlov. Cond. magazine entry latency0.20.30.4-0.70.40.4
Pavlov. Cond. change in total contacts1.71.82.7-1.71.11.2
Pavlov. Cond. index score2.43.04.7-2.22.00.6
Pavlov. Cond. latency score2.22.84.3-2.11.90.6
Pavlov. Cond. lever contacts5.66.69.8-3.13.01.0
Pavlov. Cond. magazine entry number0.30.30.60.8-0.6-0.1
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.40.3-0.1
Pavlov. Cond. lever-magazine prob. diff.2.22.74.4-2.11.90.3
Pavlov. Cond. response bias2.63.35.3-2.32.00.8
Pavlov. Cond. lever latency1.41.92.61.6-1.31.1
Pavlov. Cond. magazine entry latency0.30.30.60.5-0.4-0.8
Pavlov. Cond. change in total contacts0.91.53.7-0.60.6-1.9
Pavlov. Cond. index score0.50.61.8-0.30.2-1.3
Pavlov. Cond. latency score0.60.92.2-0.50.4-1.5
Pavlov. Cond. lever contacts1.01.41.8-1.41.1-1.1
Pavlov. Cond. magazine entry number0.70.92.70.2-0.31.6
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.60.50.3
Pavlov. Cond. lever-magazine prob. diff.0.60.82.2-0.30.2-1.5
Pavlov. Cond. response bias0.71.01.8-0.80.7-1.3
Time in closed arm before self-admin0.30.40.80.9-0.6-0.2
Time in closed arm after self-admin0.40.40.60.6-0.6-0.8
Time in open arm before self-admin0.91.01.5-1.10.61.2
Time in open arm after self-admin0.80.91.1-1.00.91.0
Bone: periosteal estimation1.12.34.1-2.01.60.1
Bone: periosteal perimeter0.40.81.0-1.00.70.9
Bone: post-yield work1.72.63.8-1.91.61.1
Progressive ratio test 1 active lever presses0.20.20.30.3-0.60.6
Progressive ratio test 1 breakpoint0.20.20.40.1-0.40.6
Progressive ratio test 1 inactive lever presses0.60.92.1-0.80.31.4
Progressive ratio test 2 active lever presses0.60.71.00.7-1.00.7
Progressive ratio test 2 breakpoint0.70.71.10.7-1.10.8
Progressive ratio test 2 inactive lever presses0.00.10.1-0.2-0.10.3
Incentive Sensitization - Responses0.20.30.60.3-0.80.5
Incentive Sensitization - Breakpoint0.40.51.00.5-1.00.5
Sum of active levers in priming session hrs 5-64.54.26.02.2-2.41.3
Progressive ratio0.10.20.40.4-0.30.6
Food seeking constrained by brief footshock6.57.911.7-3.42.91.9
Seeking ratio, punishment vs. effort2.23.25.4-2.32.00.3
Retroperitoneal fat weight0.31.42.41.5-1.0-0.9
Reaction time number correct0.10.20.50.3-0.40.7
Reaction time mean minus median1.12.88.3-0.20.4-2.9
Reaction time mean minus median AUC0.92.35.7-0.90.8-2.4
Reaction time num false alarms0.40.51.4-0.30.2-1.2
Reaction time num false alarms AUC0.30.50.6-0.80.7-0.6
Reaction time trials correct on left0.10.20.50.3-0.40.7
Reaction time trials on left0.20.30.40.4-0.50.7
Reaction time mean2.03.26.21.4-1.1-2.5
Reaction time mean AUC2.23.57.21.5-1.1-2.7
Median of all reaction times2.23.24.02.0-1.6-1.7
Reaction time omissions2.33.45.62.1-2.4-0.4
Reaction time false alarm rate0.30.41.1-0.30.4-1.0
Reaction time premature initiation rate2.63.75.32.3-2.1-1.2
Reaction time premature initiations1.83.24.92.2-2.1-0.6
Std. dev. reaction times1.62.98.30.6-0.3-2.9
Reaction time trials completed0.20.30.40.4-0.50.7
Reaction time trials AUC0.10.30.40.4-0.50.6
Run reversals in cocaine runway, females0.50.41.30.3-0.1-1.1
Run reversals in cocaine runway, males0.20.20.40.3-0.6-0.2
Latency to leave start box in cocaine runway1.11.32.5-1.21.6-0.1
Latency to leave start box in cocaine runway, F0.20.30.60.4-0.20.8
Latency to leave start box in cocaine runway, M4.44.16.6-2.42.6-0.0
Std. dev. time between licks in bursts0.60.81.30.9-1.2-0.4
Total sessions with >9 infusions0.20.20.4-0.3-0.20.7
Short access day 1 total inactive lever presses1.11.43.1-0.90.61.8
Short access day 10 total inactive lever presses0.41.01.6-1.11.30.5
Short access day 1 total infusions0.50.61.6-0.40.11.3
Short access day 10 total infusions0.50.60.90.5-0.81.0
Short access total infusions0.40.51.10.2-0.51.0
Short access day 1 locomotion1.41.72.61.6-1.60.4
Short access day 10 total locomotion0.71.41.81.3-0.9-1.2
Short access total locomotion0.70.91.41.1-1.2-0.0
One hour access (0.3 mA shock)0.30.40.70.2-0.80.7
Compulsive drug intake0.00.00.10.10.2-0.3
One hour access (shock baseline)0.50.81.60.2-0.91.2
Social response proportion0.70.81.61.3-0.9-0.4
Social responses0.30.30.7-0.90.40.3
Social time0.30.50.80.4-0.90.6
Soleus weight0.82.46.50.3-0.82.5
Bone: stiffness3.65.99.9-3.12.8-0.2
Tibialis anterior weight5.016.927.5-5.24.71.2
Time to tail flick, vehicle, before self-admin1.71.72.91.5-1.7-0.3
Time to tail flick, vehicle, after self-admin0.10.10.3-0.1-0.4-0.5
Time to tail flick, test, before self-admin0.30.30.5-0.70.60.0
Time to tail flick, test, after self-admin0.80.81.6-0.70.5-1.3
Delta time to tail flick, vehicle, before/after SA0.50.50.7-0.90.80.0
Delta time to tail flick, test, before/after SA0.40.40.70.6-0.4-0.9
Tibia length0.41.22.8-0.70.51.7
Ambulatory time before self-admin2.63.96.2-2.52.01.2
Ambulatory time after self-admin2.63.15.2-2.02.30.3
Bone: tissue strength0.10.10.2-0.40.4-0.2
Total heroin consumption1.11.32.01.1-1.40.8
Bone: trabecular number0.91.41.9-1.31.4-0.8
Bone: trabecular spacing0.10.20.4-0.30.2-0.6
Bone: trabecular thickness0.10.10.20.3-0.1-0.4
Bone: trabecular tissue density3.34.97.4-2.72.7-0.0
Water consumed over 24 hours1.31.72.6-1.61.60.2
Number of responses in last shaping day2.12.46.60.1-0.62.6