Hub : Genes

Rbm14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	isoform ratio	NM_133388.1	0.33	0.21	5.4e-04	0.12	0.17	0.1	0.1	7.9e-04	6.5e-05	2.2e-03	2.8e-03
2	PL	isoform ratio	NM_133388.1	0.03	0.02	6.0e-03	0.01	0.01	0	0.01	1.4e-02	2.6e-02	1.6e-01	4.1e-02
3	NAcc	intron excision ratio	chr1_211508086_211515412	0.04	0.04	5.5e-04	0.01	0.01	0.01	0.01	3.3e-02	6.7e-03	1.6e-02	2.1e-02
4	Brain	intron excision ratio	chr1_211508086_211515412	0.03	0.02	7.1e-03	0.01	0.03	0.02	0.03	2.0e-02	2.2e-03	3.0e-03	1.5e-03
5	Adipose	gene expression	Rbm14	0.07	0.06	1.5e-03	0.03	0.02	0.04	0.02	4.7e-04	2.4e-03	6.9e-05	1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.1	1.8	5.3	-1.6	-1.0	0.1	-0.3	-2.3
Area under the delay curve	0.5	0.6	1.1	0.2	0.3	-0.8	-1.0	1.0
BMI with tail	1.5	5.1	10.1	-3.2	-2.4	1.1	0.7	-2.8
BMI without tail	0.5	1.4	2.8	-1.7	-1.6	0.7	0.8	-0.8
Body weight	2.1	9.3	13.3	-3.5	-3.6	2.9	2.8	-2.3
Weight adjusted by age	2.0	3.0	3.8	-1.6	-1.6	1.8	1.7	-1.9
Bone surface	5.1	9.3	14.9	-3.8	-3.1	2.3	1.4	-3.9
Bone volume	2.5	4.5	10.9	-2.6	-1.8	1.1	0.3	-3.3
Breakpoint value in progressive ratio session	3.2	3.9	6.1	-2.5	-2.1	2.2	1.5	-1.3
Number of licking bursts	0.3	0.5	1.0	-1.0	-0.7	0.8	0.3	-0.5
Context. condit. distance diff. score	1.6	1.9	2.9	1.7	1.7	-1.6	-1.2	0.1
Locomotion velocity, session 1	0.2	0.2	0.9	0.6	-0.0	-0.0	0.2	0.9
Locomotion distance, session 1	0.2	0.3	0.7	-0.9	-0.8	0.1	-0.2	-0.1
Locomotion velocity, session 2	2.2	2.5	3.7	-1.6	-1.9	1.5	1.5	-1.4
Locomotion distance, session 2	0.3	0.4	1.1	-0.8	-1.0	0.4	0.3	0.4
Locomotion velocity, session 3	0.1	0.2	0.4	0.1	0.3	-0.6	-0.6	0.1
Locomotion distance, session 3	0.0	0.0	0.2	0.1	0.1	-0.1	-0.2	0.4
Stereotopy head waving bouts, day 3	1.6	1.9	3.1	1.1	1.1	-1.5	-1.2	1.8
Stereotopy head waving duration, day 3	1.4	1.6	2.3	1.1	1.2	-1.5	-1.4	1.1
Locomotion velocity, session 7	0.2	0.3	0.6	0.3	0.4	-0.8	-0.5	-0.4
Locomotion distance, session 7	0.0	0.1	0.1	0.3	-0.0	-0.3	0.2	-0.2
Stereotopy head waving bouts, day 7	0.3	0.4	0.9	-0.7	0.1	-0.2	-0.6	-1.0
Stereotopy head waving duration, day 7	1.1	1.4	2.8	-1.7	-0.9	0.7	0.3	-1.7
Locomotion velocity, session 8	0.7	0.8	1.3	-0.7	-1.2	1.0	1.1	-0.3
Locomotion distance, session 8	0.3	0.4	0.6	0.5	0.6	-0.8	-0.8	-0.0
Degree of sensitization distance	0.1	0.1	0.3	0.0	-0.0	-0.3	0.0	-0.6
Degree of sensitization stereotypy	1.3	1.4	3.7	-1.5	-0.8	0.8	0.4	-1.9
Conditioned locomotion	1.5	1.8	3.5	-0.8	-1.4	1.5	1.9	-0.7
Cocaine response after cond. corrected	1.1	1.3	1.9	1.4	1.3	-1.1	-0.8	1.1
Cocaine response after cond. not corrected	0.8	1.0	1.2	0.9	1.0	-1.0	-0.9	1.1
Cocaine response before conditioning	0.8	0.9	2.1	-1.5	-1.1	1.0	0.2	-0.6
Saline control response	2.8	3.7	6.6	-2.3	-2.6	2.0	1.6	-0.6
Bone: connectivity density	2.6	4.1	7.3	-2.6	-2.1	1.2	0.7	-2.7
Bone: cortical apparent density	0.2	0.2	0.6	-0.1	-0.4	0.6	0.7	0.5
Bone: cortical area	1.1	1.6	2.0	-1.2	-1.3	1.4	1.1	-1.3
Bone: cortical porosity	0.2	0.2	0.7	-0.4	-0.2	-0.1	-0.1	-0.9
Bone: cortical porosity	0.4	0.4	1.3	-0.5	-0.6	0.2	0.4	-1.1
Bone: cortical thickness	3.6	6.0	10.1	-1.7	-2.6	3.0	3.2	-0.9
Bone: cortical thickness	0.9	1.1	2.8	-0.0	-1.0	1.1	1.7	0.7
Bone: cortical tissue density	0.3	0.4	0.9	-0.2	-0.5	0.7	0.9	0.4
Condit. Reinf. active minus inactive responses	0.3	0.3	1.0	-1.0	-0.6	0.5	0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	-0.8	-0.3	0.4	-0.1	-0.2
Condit. Reinf. active responses	0.2	0.2	0.6	-0.8	-0.5	0.4	0.0	-0.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.0	0.1	-0.1	-0.2	0.2
Incentive salience index mean	0.4	0.5	1.1	-1.1	-0.8	0.6	0.3	-0.7
Condit. Reinf. lever presses	0.7	1.0	1.8	-1.1	-0.9	0.9	0.6	-1.3
Condit. Reinf. active minus inactive responses	0.3	0.4	1.2	-0.7	0.1	-0.3	-1.1	-0.4
Condit. Reinf. active-inactive response ratio	0.6	0.7	2.6	-0.1	0.7	-0.7	-1.6	-0.0
Condit. Reinf. active responses	0.4	0.6	1.4	-1.2	-0.4	-0.0	-0.7	-1.0
Condit. Reinf. inactive responses	0.4	0.5	1.0	-0.9	-0.8	0.1	0.4	-1.0
Condit. Reinf. lever presses	2.5	3.5	6.0	-2.4	-2.0	1.6	0.9	-2.0
Condit. Reinf. lever reinforcers received	0.6	0.8	2.0	-1.4	-0.7	0.3	-0.4	-1.1
Conditioned reinforcement - actives	0.1	0.1	0.5	-0.2	-0.1	0.4	-0.1	-0.7
Conditioned reinforcement - inactives	1.4	2.1	3.3	1.1	1.8	-1.5	-1.8	-0.6
Conditioned locomotion	6.0	7.8	10.8	3.0	3.3	-2.9	-3.0	1.2
Patch foraging indifference point 0 sec	0.1	0.2	0.6	-0.1	0.2	-0.4	-0.8	0.3
Patch foraging indifference point AUC	2.4	3.5	4.7	-1.7	-1.9	2.1	2.2	-1.4
Delay disc. indifference point, 0s delay	1.4	1.5	2.4	1.1	1.0	-1.6	-1.2	1.2
Delay disc. indifference point, 16s delay	0.8	0.9	2.3	0.3	0.8	-1.0	-1.5	0.6
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	0.2	0.4	-0.7	-0.8	0.4
Delay disc. indifference point, 24s delay	0.4	0.4	1.5	0.7	0.3	-0.3	-0.2	1.2
Delay disc. indifference point, 4s delay	0.7	0.7	1.4	0.6	0.4	-1.0	-0.8	1.2
Delay disc. indifference point, 8s delay	0.5	0.6	1.7	0.4	0.3	-0.7	-0.8	1.3
Indifference point function ln k	7.2	12.6	14.9	3.9	3.7	-3.6	-3.3	3.3
Indifference point function log k	7.2	12.6	14.9	3.9	3.7	-3.6	-3.3	3.3
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	0.1	0.1	-0.2	-0.4	0.7
Patch foraging total patch changes 12 sec	4.1	5.3	7.5	-2.5	-2.7	2.3	2.2	-1.7
Patch foraging total patch changes 18 sec	0.5	0.8	1.1	-1.1	-1.0	0.7	0.8	-0.7
Patch foraging total patch changes 24 sec	1.3	2.2	3.6	-1.4	-1.9	1.7	1.6	-0.1
Patch foraging total patch changes 6 sec	1.3	2.0	2.9	-1.6	-1.7	1.2	1.2	-1.3
Patch foraging time to switch 0 sec	1.3	2.6	6.1	-2.5	-1.6	1.2	0.7	-1.6
Patch foraging water rate 0 sec	2.6	5.5	9.5	3.1	2.6	-1.9	-1.7	2.2
Patch foraging water rate 12 sec	6.7	14.0	22.8	4.8	3.9	-3.4	-2.7	3.6
Patch foraging water rate 18 sec	3.1	4.8	7.1	2.5	2.0	-1.9	-1.7	2.7
Patch foraging water rate 24 sec	4.0	5.6	10.3	3.2	2.6	-2.1	-1.7	1.9
Patch foraging water rate 6 sec	4.5	6.5	10.8	3.3	2.4	-2.1	-1.6	3.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.8	-0.2	0.1	-0.5	-0.9	0.7
Distance traveled before self-admin	0.7	0.9	2.3	-1.1	-0.8	0.5	-0.1	-1.5
Distance traveled after self-admin	0.3	0.4	0.9	-0.8	-0.6	0.5	0.2	-0.9
Extensor digitorum longus weight	7.0	27.4	35.3	-5.1	-5.9	5.7	5.6	-3.5
Bone: elastic displacement	0.9	1.0	2.3	1.5	0.8	-0.3	0.3	1.4
Bone: elastic work	1.2	1.6	3.7	-0.4	-1.3	1.4	1.9	0.4
Bone: endosteal estimation	1.1	2.4	5.7	0.8	1.4	-2.0	-2.4	0.2
Bone: endosteal perimeter	1.5	3.3	10.1	0.2	1.5	-2.0	-3.2	0.3
Epididymis fat weight	2.9	9.8	14.6	3.1	3.8	-3.4	-3.5	0.8
Delta time in closed arm before/after self-admin	0.4	0.4	1.3	0.3	-0.5	0.3	1.1	-0.5
Delta time in open arm before/after self-admin	0.9	0.9	2.9	-0.9	-0.4	0.7	0.4	-1.7
Diff in mean of infusions in LGA sessions	0.9	1.1	1.3	-1.0	-1.0	1.2	1.1	-1.0
Delay discount exponential model param	0.4	0.5	1.1	-0.1	-0.2	0.6	0.9	-1.0
Extinction: sum of active levers before priming	2.3	2.5	4.9	-2.2	-1.8	1.6	1.0	-1.0
Active lever presses in extinction session 6	5.8	5.8	13.0	-2.1	-1.9	2.2	1.8	-3.6
Bone: final force	2.0	3.2	4.6	-1.9	-2.1	1.8	1.5	-1.5
Bone: final moment	1.8	3.0	4.2	-1.8	-2.1	1.7	1.4	-1.5
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.3	-0.2	0.5	0.2	-0.4
Glucose	2.6	4.1	6.8	1.4	2.0	-2.6	-2.6	1.0
Heart weight	1.4	2.1	4.7	1.1	1.3	-2.2	-1.7	-0.1
Delay discount hyperbolic model param	0.4	0.5	1.0	-0.1	-0.2	0.7	0.9	-1.0
Intermittent access intake day 1-15 change	0.4	0.9	1.6	1.0	1.3	-0.8	-1.0	-0.4
Intermittent access intake escalation	0.3	0.6	1.2	0.8	1.1	-0.6	-0.8	-0.2
Intermittent access intake escalation 2	0.6	0.7	1.5	0.9	1.2	-0.6	-0.8	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.0	0.5	-0.0	-0.0	0.2
Intermitt. access day 15 inactive lever presses	0.5	0.9	2.0	0.4	1.2	-1.0	-1.4	0.3
Intermitt. access escalation Index	3.3	4.6	6.5	2.3	2.1	-2.6	-2.2	1.4
Intermittent access day 1 total infusions	2.2	3.5	6.7	0.8	1.6	-2.3	-2.6	-1.4
Intermittent access day 15 total infusions	2.9	4.3	7.3	1.5	2.4	-2.3	-2.7	-1.0
Intermittent access terminal intake (last 3 days)	3.0	4.0	6.7	1.1	2.1	-2.2	-2.6	-1.7
Intermittent access total infusions	2.7	3.2	5.9	0.8	1.7	-2.0	-2.4	-1.6
Intermittent access day 1 locomotion	1.6	2.1	4.0	0.7	1.5	-1.8	-2.0	-0.7
Intermittent access day 15 total locomotion	1.9	3.4	6.9	1.1	2.0	-2.1	-2.6	-0.4
Intermittent access total locomotion	4.9	5.9	11.9	1.4	2.5	-2.8	-3.4	-1.2
Intermittent access standard deviation	0.5	1.0	1.7	1.1	1.3	-1.0	-0.9	-0.2
Left kidney weight	0.7	3.5	4.6	2.1	2.0	-2.1	-1.8	1.0
Right kidney weight	0.4	1.9	2.9	1.7	1.5	-1.3	-1.2	1.3
Cocaine induced anxiety	0.1	0.1	0.2	-0.5	-0.1	0.3	0.1	-0.5
Post-drug Anxiety	0.6	0.7	1.0	-1.0	-0.8	1.0	0.8	-0.5
Baseline Anxiety	0.2	0.2	0.4	-0.1	-0.6	0.5	0.6	0.3
Tail length	0.4	1.6	3.9	-0.2	-1.3	1.4	2.0	0.6
Length with tail	1.6	6.8	11.3	-1.9	-3.0	3.1	3.4	-0.8
Length without tail	1.8	5.7	9.0	-1.8	-2.7	2.7	3.0	-1.2
Times rat made contact with spout	0.3	0.3	0.6	-0.7	-0.8	0.4	0.5	-0.3
Lifetime Intake	2.0	2.5	3.9	0.7	1.4	-1.8	-2.0	-1.6
Liver weight, left	1.2	2.0	3.9	2.0	1.3	-1.2	-0.5	1.6
Liver weight, right	2.6	4.6	6.3	2.5	2.1	-2.1	-1.5	2.4
Locomotor activity	1.8	2.8	5.4	2.3	1.7	-1.4	-1.0	1.7
Locomotor testing distance	2.4	4.4	7.8	2.8	2.0	-1.8	-1.3	2.2
Locomotor testing rearing	2.0	3.9	5.9	2.4	2.1	-2.2	-1.6	1.4
Locomotion in novel chamber	4.5	5.7	7.5	2.5	2.6	-2.7	-2.7	1.0
Locomotion in novel chamber post-restriction	1.8	3.0	4.0	1.8	1.9	-2.0	-1.9	-0.3
Fecal boli incidents, locomotor time 1	0.3	0.4	1.3	-0.4	0.2	0.4	0.5	-1.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	0.3	0.0	-0.5	-0.6	0.9
Time >=10cm from walls, locomotor time 1	1.0	1.1	3.1	-0.3	0.9	-1.0	-1.8	-0.5
Bouts of movement, locomotor time 1	1.6	1.8	2.4	-1.6	-1.3	1.6	1.1	-1.1
Total resting periods, locomotor time 1	1.1	1.2	2.0	-1.4	-1.0	1.3	0.7	-1.1
Rest time, locomotor task time 1	1.5	1.8	2.2	1.2	1.5	-1.1	-1.5	1.4
Distance moved, locomotor task time 1	0.3	0.4	0.8	-0.8	-0.7	0.1	0.0	-0.9
Vertical activity count, locomotor time 1	0.3	0.7	1.0	1.0	0.9	-0.9	-0.6	0.6
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.5	-0.0	0.2	-0.4	-0.2
Bouts of movement, locomotor time 2	0.5	0.7	1.0	-0.9	-0.9	0.7	0.8	-1.0
Total resting periods, locomotor time 2	0.2	0.4	0.8	-0.7	-0.6	0.4	0.5	-0.9
Rest time, locomotor task time 2	2.2	2.9	3.5	1.8	1.9	-1.8	-1.5	1.4
Distance moved, locomotor task time 2	1.3	1.6	2.3	-1.4	-1.5	1.5	1.0	-0.7
Vertical activity count, locomotor time 2	0.3	0.3	0.6	0.4	-0.2	0.6	0.8	0.8
Light reinforcement 1	0.2	0.6	1.5	0.6	0.5	-0.6	-0.6	1.2
Light reinforcement 2	0.6	0.9	1.8	0.6	1.1	-0.7	-1.3	0.9
Bone: marrow area	1.2	2.7	6.1	0.8	1.5	-2.1	-2.5	0.2
Bone: maximum diameter	0.2	0.4	0.8	-0.9	-0.5	0.6	-0.2	-0.9
Bone: maximum force	3.1	5.5	9.5	-3.1	-2.6	2.1	1.2	-2.3
Bone: maximum moment	2.9	5.1	8.6	-2.9	-2.5	2.0	1.2	-2.2
Mean time between licks in bursts	0.1	0.2	0.4	-0.0	-0.4	0.4	0.6	0.5
Mean num. licks in bursts	0.2	0.4	0.7	0.8	0.5	-0.8	-0.3	0.4
Cd content in liver	1.0	1.1	1.9	0.8	1.1	-1.2	-1.4	0.5
Co content in liver	2.6	3.0	7.0	2.3	1.4	-0.9	-0.2	2.6
Cu content in liver	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.3	0.1
Fe content in liver	0.2	0.2	0.4	-0.1	-0.4	0.5	0.7	0.5
K content in liver	0.3	0.3	0.6	-0.7	-0.7	0.4	0.4	-0.3
Mg content in liver	0.5	0.5	0.7	0.4	0.6	-0.8	-0.8	0.8
Mn content in liver	4.5	5.0	6.9	-2.6	-2.2	2.4	1.9	-2.0
Na content in liver	0.5	0.5	0.9	-0.5	-0.7	0.9	0.4	0.9
Rb content in liver	1.9	2.2	3.5	1.5	1.5	-1.9	-1.4	0.9
Se content in liver	0.1	0.1	0.3	-0.3	0.2	-0.2	-0.5	-0.5
Sr content in liver	3.0	2.6	3.4	-1.3	-1.5	1.8	1.8	-1.5
Zn content in liver	0.2	0.2	0.3	-0.3	-0.6	0.4	0.6	-0.4
Bone: minimum diameter	1.0	1.8	4.9	0.1	1.0	-1.7	-2.2	-0.4
Time in familiar zone, hab. session 1	0.3	0.2	0.7	-0.1	0.5	-0.5	-0.8	-0.3
Time in novel zone, hab. session 1	0.4	0.4	1.0	1.0	0.5	-0.4	0.1	0.8
Total zone transitions, hab. session 1	0.8	1.1	1.5	-1.2	-1.2	1.0	0.8	-0.9
Total locomotion distance, hab. session 1	0.4	0.5	0.8	0.5	0.7	-0.7	-0.9	0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.0	0.2	-0.2	-0.4	0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.4	0.5	0.1	0.1	0.6	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.5	-0.2	-0.2	-0.5	0.2
Total zone transitions, hab. session 2	0.9	1.2	3.1	-1.8	-1.3	0.2	-0.1	-1.1
Total locomotion distance, hab. session 2	0.3	0.4	1.1	-0.2	0.2	-0.8	-1.1	0.6
Locomotion velocity, hab. session 2	0.5	0.6	1.6	-0.2	0.4	-0.9	-1.3	0.6
Novel to familiar place preference ratio	1.2	1.3	2.7	-1.7	-1.1	1.0	0.4	-1.2
Novelty place preference	0.6	0.6	1.6	-1.2	-0.7	0.6	0.0	-0.9
Time in novel zone, NPP test	0.4	0.4	1.1	-1.0	-0.6	0.4	-0.0	-0.8
Total zone transitions, NPP test	1.4	2.0	3.3	-1.8	-1.8	1.2	0.9	-1.1
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.1	-0.1	-0.2	-0.4	0.4
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.2	-0.2	-0.1	-0.4	0.4
Intraocular pressure	0.6	0.8	1.7	0.9	1.3	-0.4	-0.3	1.1
Delta distance traveled before/after self-admin	0.2	0.2	0.8	0.6	0.2	-0.1	0.3	0.9
Delta ambulatory time before/after self-admin	0.3	0.3	1.3	0.4	0.0	0.0	0.4	1.2
Parametrial fat weight	3.3	7.8	11.0	2.8	3.3	-3.2	-2.9	1.4
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.5	0.5	-0.4	-0.6	0.2
Pavlov. Cond. magazine entry latency	0.6	0.8	2.5	-1.0	-0.4	0.2	-0.2	-1.6
Pavlov. Cond. change in total contacts	0.5	0.6	1.3	-1.1	-0.3	0.4	-0.2	-1.1
Pavlov. Cond. index score	0.3	0.4	1.0	-0.7	-0.4	0.5	0.3	-1.0
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.5	-0.3	0.2	0.1	-0.6
Pavlov. Cond. lever contacts	0.0	0.1	0.1	-0.2	-0.2	0.1	0.2	-0.4
Pavlov. Cond. magazine entry number	0.7	0.8	2.1	0.9	0.6	-0.8	-0.4	1.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.5	0.4	0.3	-0.2	-0.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.6	-0.9	-0.6	0.6	0.3	-1.3
Pavlov. Cond. response bias	0.5	0.6	1.6	-0.7	-0.5	0.6	0.4	-1.3
Pavlov. Cond. lever latency	0.7	1.0	1.2	1.1	1.1	-1.1	-0.8	0.9
Pavlov. Cond. magazine entry latency	5.1	6.1	9.5	-3.1	-2.6	2.3	1.7	-2.5
Pavlov. Cond. change in total contacts	2.1	3.3	6.5	-2.5	-1.8	1.6	0.7	-1.9
Pavlov. Cond. index score	3.0	4.1	6.6	-2.6	-2.1	1.9	1.2	-2.0
Pavlov. Cond. latency score	2.8	3.7	5.8	-2.4	-2.0	1.8	1.2	-1.9
Pavlov. Cond. lever contacts	0.7	1.0	1.4	-1.2	-1.1	1.0	0.7	-0.9
Pavlov. Cond. magazine entry number	7.8	9.6	14.7	3.8	3.4	-3.0	-2.2	2.9
Pavlov. Cond. intertrial magazine entries	1.2	1.8	2.2	1.3	1.5	-1.2	-1.3	1.4
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.9	7.7	-2.8	-2.3	2.1	1.4	-2.2
Pavlov. Cond. response bias	2.3	3.2	5.2	-2.3	-1.9	1.7	1.1	-1.7
Time in closed arm before self-admin	0.4	0.5	1.7	-0.0	0.6	-0.7	-1.3	-0.5
Time in closed arm after self-admin	0.2	0.2	0.5	0.4	0.4	-0.4	-0.3	-0.7
Time in open arm before self-admin	1.4	1.5	5.2	1.3	0.3	-0.6	0.2	2.3
Time in open arm after self-admin	0.1	0.1	0.3	0.1	-0.1	0.2	0.5	-0.2
Bone: periosteal estimation	0.1	0.2	0.6	-0.4	-0.0	-0.2	-0.7	-0.7
Bone: periosteal perimeter	0.3	0.5	1.2	-1.1	-0.5	0.2	-0.7	-0.8
Bone: post-yield work	2.2	3.3	6.9	-2.6	-0.9	-0.1	-1.5	-2.5
Progressive ratio test 1 active lever presses	0.2	0.2	0.7	-0.1	0.2	-0.3	-0.5	-0.9
Progressive ratio test 1 breakpoint	0.2	0.3	1.0	-0.2	0.1	-0.2	-0.5	-1.0
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.2	0.2	-0.1	-0.2	-0.5
Progressive ratio test 2 active lever presses	1.2	1.5	3.2	0.6	1.3	-1.4	-1.8	-0.1
Progressive ratio test 2 breakpoint	1.2	1.3	3.0	0.6	1.3	-1.3	-1.7	-0.1
Progressive ratio test 2 inactive lever presses	4.3	7.0	11.3	2.2	3.1	-3.1	-3.4	0.0
Incentive Sensitization - Responses	0.1	0.2	0.5	-0.7	-0.1	-0.1	-0.5	-0.3
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	-0.5	0.1	-0.2	-0.6	-0.1
Sum of active levers in priming session hrs 5-6	2.6	2.5	4.9	-1.4	-1.2	2.2	1.6	-1.1
Progressive ratio	1.3	2.0	5.7	-1.6	-1.3	0.2	0.1	-2.4
Food seeking constrained by brief footshock	0.4	0.5	1.6	-0.2	-0.7	0.4	0.6	1.3
Seeking ratio, punishment vs. effort	2.4	3.5	11.2	1.9	1.4	-0.7	-0.5	3.3
Retroperitoneal fat weight	9.1	38.7	49.6	6.4	7.0	-6.8	-6.5	3.7
Reaction time number correct	0.2	0.4	0.7	-0.2	-0.5	0.8	0.8	-0.5
Reaction time mean minus median	2.0	5.0	7.6	-2.8	-2.3	2.4	1.8	-1.8
Reaction time mean minus median AUC	1.0	2.6	3.9	-1.7	-1.7	2.0	1.7	-0.7
Reaction time num false alarms	0.6	0.8	2.0	1.3	0.4	-0.4	0.3	1.4
Reaction time num false alarms AUC	0.3	0.4	1.0	0.5	-0.3	0.3	0.8	1.0
Reaction time trials correct on left	0.2	0.4	0.7	-0.2	-0.5	0.8	0.8	-0.5
Reaction time trials on left	0.3	0.5	0.9	-0.3	-0.6	0.9	1.0	-0.6
Reaction time mean	0.1	0.1	0.2	-0.5	-0.2	0.3	-0.0	-0.4
Reaction time mean AUC	0.1	0.1	0.3	-0.5	-0.2	0.2	-0.2	-0.4
Median of all reaction times	0.1	0.2	0.4	0.1	0.4	-0.4	-0.6	-0.1
Reaction time omissions	1.9	2.8	3.7	-1.8	-1.7	1.9	1.8	-0.8
Reaction time false alarm rate	0.4	0.6	2.0	0.9	0.2	-0.3	0.2	1.4
Reaction time premature initiation rate	1.7	2.4	3.9	-1.1	-2.0	1.6	1.7	1.1
Reaction time premature initiations	2.2	3.9	5.9	-1.5	-2.4	2.3	2.4	0.4
Std. dev. reaction times	0.8	1.4	2.3	-1.5	-1.2	1.3	1.0	-0.9
Reaction time trials completed	0.3	0.5	0.9	-0.3	-0.6	0.9	1.0	-0.6
Reaction time trials AUC	0.1	0.3	0.6	-0.1	-0.4	0.7	0.8	-0.3
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.3	-0.5	0.0	0.3	-0.6
Run reversals in cocaine runway, males	0.6	0.6	1.1	1.1	0.4	0.2	0.6	1.1
Latency to leave start box in cocaine runway	0.3	0.3	0.8	-0.4	-0.0	-0.4	-0.6	-0.9
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.2	-0.1	-0.4	-0.4	-0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.6	-0.2	0.3	-0.0	-0.5
Std. dev. time between licks in bursts	0.3	0.4	1.2	1.1	0.3	-0.2	0.6	0.6
Total sessions with >9 infusions	0.6	0.7	3.1	-0.6	-0.3	-0.2	-0.3	-1.8
Short access day 1 total inactive lever presses	1.7	2.3	3.4	1.7	1.6	-1.8	-1.5	0.5
Short access day 10 total inactive lever presses	0.2	0.5	1.4	0.6	0.7	-0.5	-0.2	1.2
Short access day 1 total infusions	1.3	1.8	2.9	0.9	1.3	-1.7	-1.6	-1.0
Short access day 10 total infusions	1.6	2.0	7.1	-0.6	0.1	-1.0	-1.3	-2.7
Short access total infusions	0.7	0.9	2.5	-0.1	0.3	-0.9	-0.9	-1.6
Short access day 1 locomotion	0.9	1.1	2.0	0.5	1.0	-1.2	-1.4	-0.8
Short access day 10 total locomotion	0.5	1.0	1.9	0.2	0.9	-1.1	-1.4	-0.9
Short access total locomotion	1.0	1.2	2.5	0.4	1.0	-1.3	-1.6	-0.8
One hour access (0.3 mA shock)	4.4	5.0	7.2	2.0	2.7	-2.6	-2.7	0.4
Compulsive drug intake	2.1	2.5	4.9	-0.2	-1.4	1.4	1.9	2.2
One hour access (shock baseline)	4.0	6.1	9.8	1.8	2.9	-2.7	-3.1	-1.2
Social response proportion	0.6	0.7	1.7	-1.3	-0.8	0.8	0.2	-0.7
Social responses	0.2	0.3	0.4	-0.5	-0.5	0.6	0.5	0.4
Social time	0.3	0.3	0.5	-0.4	-0.6	0.7	0.7	0.4
Soleus weight	4.3	12.6	17.5	4.2	3.9	-3.6	-3.0	2.9
Bone: stiffness	2.4	4.0	7.2	-2.7	-2.1	1.5	0.7	-2.3
Tibialis anterior weight	9.9	33.7	44.5	-5.2	-6.3	6.7	6.6	-3.7
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	-0.5	-0.3	0.1	0.1	-0.7
Time to tail flick, vehicle, after self-admin	0.6	0.8	2.8	-0.8	-0.7	0.1	0.1	-1.7
Time to tail flick, test, before self-admin	1.8	1.9	3.3	1.0	1.2	-1.8	-1.8	0.6
Time to tail flick, test, after self-admin	0.5	0.5	2.0	-0.5	-0.0	0.4	0.0	-1.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.4	1.0	-0.8	-0.6	0.3	0.2	-1.0
Delta time to tail flick, test, before/after SA	2.2	2.3	4.3	-1.0	-1.0	2.1	2.0	-1.1
Tibia length	1.1	3.2	4.7	-1.8	-2.0	2.2	1.4	-1.3
Ambulatory time before self-admin	0.9	1.4	4.1	-1.4	-0.7	0.6	-0.2	-2.0
Ambulatory time after self-admin	0.5	0.6	1.6	-0.3	0.4	-0.5	-1.0	-1.3
Bone: tissue strength	0.2	0.2	0.6	-0.4	-0.1	-0.0	-0.2	-0.8
Total heroin consumption	4.0	4.7	6.8	-2.5	-2.6	2.5	2.0	-0.4
Bone: trabecular number	1.9	3.2	9.7	-2.0	-1.3	0.6	0.0	-3.1
Bone: trabecular spacing	1.0	1.3	3.2	1.4	0.9	-0.8	-0.2	1.8
Bone: trabecular thickness	0.7	0.9	2.3	-0.2	0.5	-0.8	-1.2	-1.5
Bone: trabecular tissue density	3.2	4.7	6.9	2.5	2.6	-2.0	-2.0	1.6
Water consumed over 24 hours	0.7	0.9	1.6	-1.1	-1.2	1.0	0.9	-0.2
Number of responses in last shaping day	0.1	0.1	0.2	0.4	0.2	-0.1	0.4	0.3