Hub : Genes

Slc39a14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Slc39a14	0.05	0.05	2.1e-04	0.04	0.04	0.03	0.04	9.3e-05	9.9e-05	3.7e-04	2.2e-04
2	Brain	mRNA stability	Slc39a14	0.08	0.08	6.4e-06	0.05	0.06	0.05	0.05	2.7e-05	2.9e-06	9.8e-06	2.3e-05
3	Adipose	alternative TSS	XM_063274299.1	0.02	0.02	5.7e-03	0.01	0.01	0	0.01	1.2e-02	1.2e-02	1.4e-01	2.9e-02
4	PL	mRNA stability	Slc39a14	0.03	0.03	1.7e-03	0.02	0.02	0.02	0.01	2.8e-03	4.1e-03	2.2e-03	7.2e-03
5	Liver	gene expression	Slc39a14	0.03	0.03	1.9e-03	0.02	0.02	0.01	0.02	8.9e-04	3.2e-03	3.5e-02	3.8e-03
6	PL	gene expression	Slc39a14	0.58	0.32	3.0e-10	0.08	0.09	0.09	0.09	2.5e-09	1.2e-09	2.4e-10	2.8e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.1	1.9	2.3	1.5	1.4	-1.4	1.4	-1.3	1.3
Area under the delay curve	0.1	0.1	0.4	-0.3	-0.2	0.2	-0.3	0.3	-0.6
BMI with tail	0.4	1.2	1.5	-1.2	-1.2	1.2	-1.2	1.1	-0.5
BMI without tail	0.0	0.1	0.5	-0.0	-0.0	-0.0	0.1	-0.3	0.7
Body weight	0.6	2.7	3.0	-1.6	-1.7	1.7	-1.7	1.6	-1.4
Weight adjusted by age	1.5	2.2	2.4	-1.4	-1.5	1.5	-1.5	1.5	-1.5
Bone surface	0.5	0.9	1.2	1.1	1.0	-1.0	1.0	-0.7	0.6
Bone volume	0.6	1.0	1.3	1.1	1.1	-1.1	1.1	-0.9	0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.3	0.3	-0.5
Number of licking bursts	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	-0.1	0.0
Context. condit. distance diff. score	1.4	1.7	4.6	1.1	1.0	-1.0	1.1	-1.2	2.1
Locomotion velocity, session 1	0.2	0.2	0.3	-0.5	-0.4	0.4	-0.5	0.5	-0.5
Locomotion distance, session 1	0.1	0.1	0.3	0.0	0.2	-0.2	0.2	-0.3	-0.5
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	0.2	-0.2	0.1	-0.2	-0.2
Locomotion distance, session 2	0.1	0.1	0.7	0.0	0.2	-0.1	0.1	-0.2	-0.9
Locomotion velocity, session 3	0.4	0.5	0.7	-0.8	-0.8	0.7	-0.7	0.8	-0.1
Locomotion distance, session 3	0.1	0.1	0.4	0.1	0.1	-0.2	0.2	-0.1	0.6
Stereotopy head waving bouts, day 3	0.7	0.8	1.0	-1.0	-0.9	0.9	-0.9	0.8	-0.9
Stereotopy head waving duration, day 3	2.4	2.9	3.1	-1.8	-1.7	1.7	-1.7	1.6	-1.7
Locomotion velocity, session 7	4.9	5.4	10.2	2.1	2.1	-2.1	2.1	-2.1	3.2
Locomotion distance, session 7	3.7	4.6	8.0	2.0	2.0	-2.0	2.0	-2.0	2.8
Stereotopy head waving bouts, day 7	1.6	1.9	2.3	-1.3	-1.3	1.3	-1.4	1.4	-1.5
Stereotopy head waving duration, day 7	2.2	2.7	3.0	-1.6	-1.6	1.6	-1.6	1.7	-1.7
Locomotion velocity, session 8	0.0	0.0	0.2	-0.0	0.0	-0.0	0.0	-0.0	0.4
Locomotion distance, session 8	0.7	1.0	1.4	0.9	1.0	-1.0	1.0	-1.2	1.0
Degree of sensitization distance	4.6	4.7	6.1	2.2	2.1	-2.1	2.1	-2.1	2.5
Degree of sensitization stereotypy	1.1	1.2	1.3	-1.0	-1.1	1.1	-1.1	1.1	-1.1
Conditioned locomotion	0.1	0.1	0.3	0.2	0.2	-0.2	0.2	-0.2	0.5
Cocaine response after cond. corrected	0.2	0.3	0.3	-0.5	-0.6	0.6	-0.5	0.5	0.3
Cocaine response after cond. not corrected	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.4	0.4	0.2
Cocaine response before conditioning	0.1	0.2	0.2	0.4	0.5	-0.4	0.4	-0.5	-0.3
Saline control response	0.1	0.1	0.2	0.4	0.4	-0.4	0.3	-0.2	-0.1
Bone: connectivity density	2.4	3.7	4.1	2.0	1.9	-1.9	1.9	-1.9	1.9
Bone: cortical apparent density	0.2	0.2	1.0	0.3	0.3	-0.3	0.3	-0.3	1.0
Bone: cortical area	0.0	0.0	0.1	0.0	0.0	-0.0	-0.0	0.1	-0.3
Bone: cortical porosity	1.4	1.5	2.5	-1.1	-1.1	1.1	-1.1	1.1	-1.6
Bone: cortical porosity	0.9	0.9	2.0	-0.9	-0.8	0.8	-0.9	0.8	-1.4
Bone: cortical thickness	0.0	0.0	0.0	0.0	0.1	-0.1	0.0	0.1	-0.1
Bone: cortical thickness	0.1	0.1	0.3	0.0	0.0	-0.0	0.0	-0.3	0.5
Bone: cortical tissue density	0.2	0.3	1.2	0.3	0.3	-0.3	0.3	-0.4	1.1
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	-0.8	-0.7	0.7	-0.7	0.6	-1.0
Condit. Reinf. active-inactive response ratio	2.0	2.2	2.4	-1.6	-1.5	1.5	-1.5	1.4	-1.3
Condit. Reinf. active responses	0.1	0.1	0.4	-0.1	0.0	-0.0	-0.0	-0.0	-0.6
Condit. Reinf. inactive responses	2.1	2.6	3.1	1.7	1.8	-1.7	1.7	-1.7	0.7
Incentive salience index mean	0.9	1.1	2.4	-1.0	-0.9	0.9	-0.9	0.8	-1.5
Condit. Reinf. lever presses	0.4	0.6	1.9	-0.7	-0.6	0.6	-0.6	0.4	-1.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.4	0.7	0.7	-0.7	0.7	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.3	0.3	-0.0
Condit. Reinf. active responses	0.9	1.2	1.3	1.1	1.1	-1.1	1.1	-1.1	0.9
Condit. Reinf. inactive responses	1.9	2.4	2.7	1.6	1.6	-1.6	1.6	-1.7	1.2
Condit. Reinf. lever presses	0.1	0.2	0.3	0.4	0.5	-0.5	0.4	-0.6	-0.3
Condit. Reinf. lever reinforcers received	0.6	0.9	1.0	1.0	1.0	-1.0	1.0	-0.9	0.8
Conditioned reinforcement - actives	1.0	1.8	2.1	1.3	1.3	-1.3	1.3	-1.3	1.5
Conditioned reinforcement - inactives	2.9	4.2	4.8	2.1	2.2	-2.2	2.1	-2.1	1.5
Conditioned locomotion	0.1	0.2	0.3	0.4	0.4	-0.4	0.4	-0.4	0.5
Patch foraging indifference point 0 sec	1.3	2.4	3.4	1.8	1.8	-1.8	1.7	-1.2	0.6
Patch foraging indifference point AUC	0.2	0.3	0.4	-0.6	-0.5	0.5	-0.5	0.5	-0.2
Delay disc. indifference point, 0s delay	0.3	0.3	0.5	0.6	0.6	-0.6	0.7	-0.5	-0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.5	0.5	-0.5	0.5	-0.5	0.3
Delay disc. indifference point, 2s delay	1.6	1.8	2.8	-1.3	-1.2	1.3	-1.3	1.3	-1.7
Delay disc. indifference point, 24s delay	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.5	0.4	-0.2
Delay disc. indifference point, 4s delay	1.8	1.8	1.9	-1.4	-1.4	1.4	-1.3	1.4	-1.4
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.1
Indifference point function ln k	0.0	0.0	0.2	0.1	0.1	-0.0	0.0	-0.2	-0.4
Indifference point function log k	0.0	0.0	0.2	0.1	0.1	-0.0	0.0	-0.2	-0.4
Patch foraging total patch changes 0 sec	0.9	1.7	2.5	1.6	1.5	-1.5	1.5	-1.0	0.3
Patch foraging total patch changes 12 sec	0.5	0.6	0.9	0.9	0.9	-0.9	0.9	-0.5	0.1
Patch foraging total patch changes 18 sec	1.1	1.7	2.1	1.3	1.5	-1.4	1.4	-1.2	1.0
Patch foraging total patch changes 24 sec	0.1	0.1	0.5	-0.0	0.0	-0.0	-0.0	0.3	-0.7
Patch foraging total patch changes 6 sec	0.2	0.2	0.3	0.6	0.6	-0.6	0.6	-0.3	0.3
Patch foraging time to switch 0 sec	0.6	1.1	1.2	1.1	1.1	-1.1	1.0	-1.1	1.1
Patch foraging water rate 0 sec	0.3	0.6	1.0	-0.7	-0.7	0.7	-0.8	0.7	-1.0
Patch foraging water rate 12 sec	0.5	1.1	1.5	-1.1	-1.0	1.0	-1.0	1.0	-1.2
Patch foraging water rate 18 sec	2.6	4.0	4.4	-2.0	-2.1	2.1	-2.1	2.0	-1.7
Patch foraging water rate 24 sec	0.1	0.2	0.3	-0.4	-0.5	0.5	-0.5	0.3	0.0
Patch foraging water rate 6 sec	2.3	3.3	5.0	-1.8	-1.7	1.7	-1.7	1.8	-2.2
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	1.7	1.3	1.0	-1.0	1.0	-1.0	1.0
Distance traveled before self-admin	0.9	1.1	2.0	-0.9	-1.0	1.0	-1.0	1.1	-1.4
Distance traveled after self-admin	2.4	2.9	3.2	-1.7	-1.8	1.8	-1.8	1.7	-1.4
Extensor digitorum longus weight	12.5	49.2	51.1	-7.1	-7.1	7.1	-7.1	7.0	-6.5
Bone: elastic displacement	0.4	0.4	0.6	0.7	0.7	-0.7	0.7	-0.8	0.2
Bone: elastic work	0.2	0.2	0.3	0.5	0.6	-0.5	0.5	-0.5	-0.4
Bone: endosteal estimation	0.1	0.2	0.4	-0.3	-0.3	0.4	-0.4	0.5	-0.6
Bone: endosteal perimeter	0.1	0.2	0.5	-0.2	-0.2	0.3	-0.3	0.4	-0.7
Epididymis fat weight	0.8	2.7	3.5	1.6	1.6	-1.6	1.6	-1.9	1.6
Delta time in closed arm before/after self-admin	4.0	3.7	4.4	2.1	2.0	-2.0	2.0	-1.9	1.5
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.5	-0.3	0.3	-0.3	0.3	-0.3
Diff in mean of infusions in LGA sessions	1.0	1.2	1.6	-1.3	-1.0	1.0	-1.1	1.0	-1.2
Delay discount exponential model param	0.4	0.5	0.9	0.7	0.6	-0.6	0.6	-0.7	0.9
Extinction: sum of active levers before priming	2.0	2.2	2.4	1.4	1.5	-1.5	1.5	-1.5	1.2
Active lever presses in extinction session 6	0.6	0.6	0.7	0.7	0.8	-0.8	0.8	-0.8	0.8
Bone: final force	0.1	0.2	0.3	-0.4	-0.4	0.4	-0.4	0.5	-0.6
Bone: final moment	0.1	0.2	0.4	-0.3	-0.3	0.3	-0.4	0.4	-0.7
Food consumed during 24 hour testing period	0.2	0.3	0.5	0.5	0.6	-0.6	0.6	-0.7	0.0
Glucose	0.0	0.0	0.2	0.0	-0.0	-0.0	-0.0	0.1	0.5
Heart weight	0.3	0.5	0.8	0.9	0.8	-0.8	0.7	-0.5	0.6
Delay discount hyperbolic model param	0.5	0.6	1.0	0.8	0.7	-0.7	0.7	-0.7	1.0
Intermittent access intake day 1-15 change	1.7	3.4	3.5	1.9	1.9	-1.9	1.9	-1.9	1.7
Intermittent access intake escalation	1.7	3.5	3.7	1.9	1.9	-1.9	1.9	-1.9	1.6
Intermittent access intake escalation 2	1.5	1.7	1.7	1.3	1.3	-1.3	1.3	-1.3	1.3
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	-0.1	0.2
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	0.2	0.2	-0.2	0.2	-0.2	0.1
Intermitt. access escalation Index	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.2	0.2	-0.4
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.0	0.0	0.0
Intermittent access day 15 total infusions	1.6	2.4	2.6	1.6	1.6	-1.6	1.6	-1.6	1.3
Intermittent access terminal intake (last 3 days)	1.1	1.4	1.5	1.2	1.2	-1.2	1.2	-1.2	1.2
Intermittent access total infusions	1.2	1.4	1.5	1.2	1.2	-1.2	1.2	-1.2	1.2
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	-0.0	-0.3
Intermittent access day 15 total locomotion	0.2	0.4	0.6	0.6	0.7	-0.7	0.6	-0.7	0.7
Intermittent access total locomotion	0.1	0.1	0.1	0.3	0.4	-0.4	0.3	-0.4	0.3
Intermittent access standard deviation	0.1	0.3	0.3	0.5	0.6	-0.6	0.5	-0.5	0.3
Left kidney weight	0.1	0.2	0.5	-0.4	-0.4	0.4	-0.5	0.4	-0.7
Right kidney weight	0.1	0.3	1.0	-0.2	-0.2	0.3	-0.3	0.7	-1.0
Cocaine induced anxiety	0.1	0.1	0.8	-0.1	-0.0	0.0	-0.1	0.2	-0.9
Post-drug Anxiety	0.7	0.8	1.0	0.9	1.0	-1.0	1.0	-0.9	0.1
Baseline Anxiety	0.5	0.6	1.0	0.6	0.7	-0.7	0.7	-0.8	1.0
Tail length	0.4	1.7	2.0	1.4	1.4	-1.4	1.4	-1.3	0.8
Length with tail	0.1	0.3	0.9	-0.3	-0.4	0.4	-0.5	0.6	-0.9
Length without tail	2.3	7.4	8.2	-2.6	-2.7	2.7	-2.7	2.9	-2.8
Times rat made contact with spout	0.5	0.6	0.8	0.7	0.8	-0.8	0.8	-0.9	0.8
Lifetime Intake	0.7	0.9	1.0	0.9	0.9	-0.9	0.9	-0.9	1.0
Liver weight, left	1.9	3.2	5.0	-1.8	-1.7	1.7	-1.7	1.5	-2.2
Liver weight, right	0.4	0.7	0.9	-0.9	-0.9	0.9	-0.9	0.6	-0.7
Locomotor activity	2.2	3.4	8.2	-1.5	-1.5	1.6	-1.6	1.6	-2.9
Locomotor testing distance	0.2	0.3	1.8	0.2	0.3	-0.2	0.2	-0.2	-1.3
Locomotor testing rearing	0.2	0.5	1.6	0.6	0.6	-0.5	0.5	-0.4	-1.3
Locomotion in novel chamber	0.5	0.6	0.8	0.9	0.8	-0.8	0.8	-0.7	0.5
Locomotion in novel chamber post-restriction	0.6	1.0	1.2	-0.9	-1.1	1.1	-1.1	1.1	-0.8
Fecal boli incidents, locomotor time 1	1.1	1.6	2.2	-1.3	-1.1	1.2	-1.2	1.2	-1.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.5	0.5	-0.1
Time >=10cm from walls, locomotor time 1	0.9	1.0	1.1	0.9	1.1	-1.1	1.1	-1.0	0.7
Bouts of movement, locomotor time 1	4.4	5.0	5.9	-2.4	-2.3	2.3	-2.2	2.2	-1.9
Total resting periods, locomotor time 1	4.3	4.7	5.7	-2.4	-2.3	2.3	-2.2	2.2	-1.7
Rest time, locomotor task time 1	1.7	2.1	2.5	-1.6	-1.5	1.5	-1.5	1.5	-1.1
Distance moved, locomotor task time 1	2.2	3.2	3.5	1.8	1.9	-1.9	1.7	-1.8	1.6
Vertical activity count, locomotor time 1	0.4	1.0	1.4	1.2	1.1	-1.1	1.0	-1.0	0.5
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.5	-0.6	-0.7	0.7	-0.6	0.7	-0.4
Bouts of movement, locomotor time 2	3.1	4.9	5.4	-2.3	-2.3	2.3	-2.2	2.2	-1.9
Total resting periods, locomotor time 2	3.0	5.3	5.7	-2.4	-2.4	2.4	-2.3	2.3	-2.0
Rest time, locomotor task time 2	0.8	1.0	1.3	-1.0	-1.1	1.1	-1.1	1.0	-0.4
Distance moved, locomotor task time 2	2.7	3.3	3.7	1.9	1.9	-1.9	1.9	-1.8	1.3
Vertical activity count, locomotor time 2	0.3	0.4	0.6	0.7	0.7	-0.7	0.7	-0.6	0.1
Light reinforcement 1	2.2	5.5	6.5	2.3	2.2	-2.3	2.2	-2.5	2.4
Light reinforcement 2	1.1	1.7	3.6	1.1	1.1	-1.1	1.1	-1.3	1.9
Bone: marrow area	0.0	0.1	0.3	-0.2	-0.2	0.2	-0.3	0.4	-0.5
Bone: maximum diameter	0.4	0.7	1.0	-0.8	-0.8	0.8	-0.8	1.0	-0.7
Bone: maximum force	0.4	0.6	1.1	-0.7	-0.7	0.7	-0.7	0.9	-1.0
Bone: maximum moment	0.3	0.5	1.2	-0.5	-0.5	0.5	-0.6	0.7	-1.1
Mean time between licks in bursts	1.1	2.7	4.1	1.6	1.6	-1.6	1.7	-2.0	1.2
Mean num. licks in bursts	0.2	0.3	0.4	0.6	0.6	-0.6	0.6	-0.6	0.6
Cd content in liver	1.3	1.5	2.2	-1.2	-1.1	1.1	-1.1	1.2	-1.5
Co content in liver	4.8	5.5	6.3	-2.5	-2.4	2.4	-2.4	2.5	-1.9
Cu content in liver	0.4	0.5	0.6	-0.7	-0.7	0.7	-0.7	0.8	-0.5
Fe content in liver	1.5	1.8	2.1	1.4	1.4	-1.4	1.4	-1.1	1.2
K content in liver	1.2	1.1	1.3	1.1	1.1	-1.1	1.1	-1.0	1.1
Mg content in liver	2.7	2.8	2.9	1.7	1.7	-1.7	1.7	-1.6	1.7
Mn content in liver	2.3	2.6	2.9	1.7	1.7	-1.7	1.7	-1.6	1.3
Na content in liver	1.4	1.5	3.5	-1.0	-0.9	1.0	-1.0	1.1	-1.9
Rb content in liver	0.1	0.1	0.3	0.2	0.1	-0.1	0.1	-0.0	0.6
Se content in liver	0.8	1.0	1.2	1.1	1.1	-1.1	1.1	-1.0	-0.1
Sr content in liver	0.0	0.0	0.0	0.1	0.2	-0.2	0.1	0.0	-0.1
Zn content in liver	0.1	0.1	0.2	0.3	0.4	-0.4	0.4	-0.2	-0.1
Bone: minimum diameter	0.2	0.4	1.0	-0.4	-0.5	0.5	-0.5	0.7	-1.0
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	0.2	0.1
Time in novel zone, hab. session 1	1.1	1.1	1.3	-1.1	-1.1	1.1	-1.1	1.1	-0.8
Total zone transitions, hab. session 1	0.2	0.3	0.9	-0.6	-0.4	0.5	-0.5	0.4	-1.0
Total locomotion distance, hab. session 1	0.0	0.1	0.4	-0.0	0.1	-0.1	0.1	-0.1	-0.6
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.3	0.4	-0.4	0.4	-0.4	-0.6
Time in familiar zone, hab. session 2	1.8	1.9	2.2	-1.5	-1.5	1.5	-1.5	1.4	-0.6
Time in novel zone, hab. session 2	0.6	0.6	0.8	0.9	0.9	-0.9	0.9	-0.8	0.3
Total zone transitions, hab. session 2	1.5	1.9	3.4	-1.3	-1.3	1.3	-1.3	1.1	-1.9
Total locomotion distance, hab. session 2	0.3	0.4	1.0	-0.6	-0.5	0.5	-0.5	0.4	-1.0
Locomotion velocity, hab. session 2	0.7	0.9	2.0	-0.9	-0.8	0.8	-0.8	0.7	-1.4
Novel to familiar place preference ratio	1.4	1.5	1.7	1.3	1.3	-1.3	1.3	-1.3	0.9
Novelty place preference	1.1	1.2	1.4	1.2	1.1	-1.1	1.2	-1.1	0.8
Time in novel zone, NPP test	0.6	0.6	0.7	0.9	0.8	-0.8	0.8	-0.8	0.5
Total zone transitions, NPP test	0.2	0.2	0.4	0.4	0.5	-0.5	0.5	-0.6	-0.2
Total locomotion distance, NPP test	2.4	3.2	3.9	1.8	1.9	-1.9	1.9	-2.0	1.0
Locomotion velocity, NPP test	2.3	3.2	3.9	1.8	1.9	-1.9	1.9	-2.0	1.0
Intraocular pressure	0.6	0.8	1.5	0.8	0.9	-0.9	0.9	-1.2	0.7
Delta distance traveled before/after self-admin	2.7	2.8	3.6	-1.9	-1.8	1.8	-1.8	1.7	-1.0
Delta ambulatory time before/after self-admin	2.5	3.0	3.6	-1.9	-1.9	1.9	-1.8	1.8	-1.1
Parametrial fat weight	1.8	4.2	5.0	2.2	2.1	-2.1	2.0	-1.9	2.0
Pavlov. Cond. lever latency	0.0	0.0	0.2	0.0	-0.0	0.0	0.0	0.1	0.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	0.1
Pavlov. Cond. change in total contacts	1.2	1.3	2.1	-1.2	-1.1	1.1	-1.1	0.9	-1.5
Pavlov. Cond. index score	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.3	0.2	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.2	-0.1	0.1	-0.2	0.1	-0.5
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	0.1	-0.1	0.1	-0.2	-0.3
Pavlov. Cond. magazine entry number	0.4	0.5	0.5	0.7	0.7	-0.7	0.7	-0.6	0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.4	0.4	-0.4	0.4	-0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	-0.5	-0.5	0.5	-0.5	0.4	-0.7
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.5	-0.4	0.4	-0.4	0.3	-0.5
Pavlov. Cond. lever latency	0.6	0.8	2.2	0.8	0.7	-0.7	0.7	-0.6	1.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.2	0.3	-0.3	0.3	-0.3	-0.3
Pavlov. Cond. change in total contacts	1.3	2.1	3.4	-1.4	-1.3	1.3	-1.4	1.2	-1.8
Pavlov. Cond. index score	0.5	0.7	2.1	-0.8	-0.7	0.7	-0.7	0.6	-1.4
Pavlov. Cond. latency score	0.4	0.5	1.8	-0.6	-0.5	0.5	-0.5	0.4	-1.3
Pavlov. Cond. lever contacts	0.3	0.4	1.6	-0.6	-0.4	0.4	-0.5	0.3	-1.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	0.3	0.3
Pavlov. Cond. intertrial magazine entries	5.0	7.6	8.2	2.8	2.8	-2.8	2.8	-2.9	2.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	2.1	-0.9	-0.7	0.8	-0.8	0.6	-1.5
Pavlov. Cond. response bias	0.4	0.5	1.8	-0.6	-0.5	0.5	-0.5	0.4	-1.4
Time in closed arm before self-admin	1.5	1.9	2.3	-1.5	-1.5	1.4	-1.4	1.4	-1.0
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.2	0.2	-0.1
Time in open arm before self-admin	0.0	0.0	0.0	0.1	0.1	-0.0	0.0	-0.0	-0.1
Time in open arm after self-admin	0.0	0.0	0.1	0.0	0.2	-0.2	0.2	-0.2	-0.1
Bone: periosteal estimation	0.1	0.1	0.3	-0.2	-0.3	0.3	-0.3	0.5	-0.6
Bone: periosteal perimeter	0.1	0.1	0.2	-0.1	-0.2	0.2	-0.2	0.4	-0.5
Bone: post-yield work	0.2	0.3	0.6	0.5	0.4	-0.4	0.4	-0.5	0.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	0.2	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	0.3	0.2
Progressive ratio test 1 inactive lever presses	0.9	1.3	1.8	1.1	1.1	-1.1	1.1	-1.1	1.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	0.2	0.2	-0.2	0.2	-0.2	0.5
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	-0.2	0.4
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.5	0.6	0.7	-0.7	0.6	-0.7	0.7
Incentive Sensitization - Responses	0.2	0.3	0.3	0.6	0.6	-0.6	0.6	-0.6	0.5
Incentive Sensitization - Breakpoint	0.3	0.4	0.5	0.7	0.7	-0.7	0.7	-0.7	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.3	0.3	-0.3	0.3	-0.4	0.6
Progressive ratio	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	0.1	0.1
Food seeking constrained by brief footshock	1.8	2.2	2.9	-1.6	-1.7	1.7	-1.6	1.5	-0.3
Seeking ratio, punishment vs. effort	0.6	0.9	1.1	-1.0	-1.0	1.0	-1.0	0.9	-0.5
Retroperitoneal fat weight	0.1	0.5	1.1	0.8	0.6	-0.6	0.6	-0.3	1.0
Reaction time number correct	0.5	0.9	1.3	-1.1	-1.0	1.0	-1.0	0.8	-0.7
Reaction time mean minus median	0.1	0.2	0.5	-0.4	-0.3	0.3	-0.4	0.5	-0.7
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.3	-0.2	0.3	-0.3	0.3	-0.5
Reaction time num false alarms	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.4	0.1	-0.5
Reaction time num false alarms AUC	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.3	-0.0	-0.3
Reaction time trials correct on left	0.5	0.9	1.3	-1.1	-1.0	1.0	-1.0	0.8	-0.7
Reaction time trials on left	0.4	0.7	1.0	-1.0	-0.9	0.9	-0.9	0.6	-0.6
Reaction time mean	0.1	0.2	0.4	-0.5	-0.4	0.4	-0.4	0.3	-0.6
Reaction time mean AUC	0.3	0.5	0.8	-0.7	-0.6	0.6	-0.6	0.5	-0.9
Median of all reaction times	0.1	0.2	0.3	-0.5	-0.4	0.4	-0.4	0.2	-0.5
Reaction time omissions	1.8	2.6	3.0	1.6	1.6	-1.6	1.6	-1.7	1.5
Reaction time false alarm rate	0.1	0.1	0.2	0.4	0.3	-0.3	0.3	-0.4	0.2
Reaction time premature initiation rate	1.5	2.1	2.7	-1.4	-1.6	1.6	-1.6	1.3	-0.9
Reaction time premature initiations	1.7	3.1	4.0	-1.8	-2.0	2.0	-1.9	1.5	-1.1
Std. dev. reaction times	0.1	0.2	0.4	-0.4	-0.4	0.4	-0.4	0.3	-0.6
Reaction time trials completed	0.4	0.7	1.0	-1.0	-0.9	0.9	-0.9	0.6	-0.6
Reaction time trials AUC	0.3	0.6	0.9	-1.0	-0.9	0.9	-0.8	0.6	-0.6
Run reversals in cocaine runway, females	3.0	3.0	3.3	1.7	1.8	-1.8	1.8	-1.8	1.5
Run reversals in cocaine runway, males	2.0	2.0	2.0	-1.4	-1.4	1.4	-1.4	1.4	-1.4
Latency to leave start box in cocaine runway	0.4	0.5	0.6	-0.7	-0.7	0.7	-0.8	0.7	-0.6
Latency to leave start box in cocaine runway, F	1.3	1.5	1.6	-1.2	-1.3	1.3	-1.3	1.3	-1.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	-0.3	0.3
Std. dev. time between licks in bursts	1.2	1.7	2.8	1.3	1.3	-1.3	1.3	-1.7	0.3
Total sessions with >9 infusions	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	0.2	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.4	0.4	-0.4	0.4	-0.3	0.0
Short access day 10 total inactive lever presses	0.1	0.2	0.3	0.5	0.5	-0.5	0.5	-0.5	0.6
Short access day 1 total infusions	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.3	0.2	0.1
Short access day 10 total infusions	0.3	0.4	0.6	-0.6	-0.6	0.6	-0.6	0.6	-0.8
Short access total infusions	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	0.2	-0.2
Short access day 1 locomotion	0.9	1.1	1.5	-1.0	-1.0	1.0	-1.0	1.1	-1.2
Short access day 10 total locomotion	0.0	0.0	0.1	0.1	0.0	-0.0	0.1	0.0	-0.3
Short access total locomotion	0.2	0.2	0.6	-0.3	-0.3	0.4	-0.4	0.4	-0.8
One hour access (0.3 mA shock)	0.6	0.7	0.8	0.9	0.9	-0.9	0.9	-0.8	0.5
Compulsive drug intake	0.5	0.6	0.8	0.9	0.9	-0.8	0.9	-0.8	0.3
One hour access (shock baseline)	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0	-0.0	-0.1
Social response proportion	0.2	0.2	0.3	-0.4	-0.4	0.4	-0.4	0.5	0.5
Social responses	1.0	1.3	1.6	1.2	1.2	-1.2	1.2	-0.9	1.3
Social time	0.3	0.4	0.6	0.8	0.7	-0.7	0.6	-0.5	0.1
Soleus weight	1.1	3.2	3.8	-1.9	-1.9	1.9	-1.9	1.6	-1.4
Bone: stiffness	0.7	1.2	1.5	-1.0	-1.0	1.0	-1.1	1.2	-1.1
Tibialis anterior weight	8.2	27.8	28.5	-5.3	-5.3	5.3	-5.3	5.3	-5.1
Time to tail flick, vehicle, before self-admin	1.0	1.1	1.1	1.0	1.0	-1.0	1.0	-1.0	1.0
Time to tail flick, vehicle, after self-admin	1.2	1.6	2.0	-1.4	-1.4	1.4	-1.4	1.3	-0.5
Time to tail flick, test, before self-admin	2.7	2.8	3.2	1.7	1.8	-1.8	1.8	-1.7	1.3
Time to tail flick, test, after self-admin	2.8	2.9	4.8	1.7	1.5	-1.5	1.6	-1.6	2.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.3	-0.5	-0.6	0.6	-0.5	0.5	0.1
Delta time to tail flick, test, before/after SA	0.2	0.2	1.2	0.2	0.0	-0.1	0.1	-0.2	1.1
Tibia length	1.0	2.7	3.6	1.8	1.9	-1.9	1.8	-1.5	0.4
Ambulatory time before self-admin	0.3	0.4	1.0	-0.6	-0.5	0.6	-0.6	0.6	-1.0
Ambulatory time after self-admin	5.1	6.0	6.3	-2.5	-2.5	2.5	-2.5	2.5	-2.3
Bone: tissue strength	0.0	0.0	0.1	0.3	0.2	-0.2	0.2	-0.0	0.1
Total heroin consumption	0.7	0.8	1.1	-0.9	-0.8	0.8	-0.9	0.9	-1.0
Bone: trabecular number	2.1	3.4	3.9	2.0	1.9	-1.9	1.9	-1.8	1.7
Bone: trabecular spacing	2.2	2.9	3.1	-1.8	-1.7	1.7	-1.7	1.8	-1.5
Bone: trabecular thickness	1.1	1.3	1.5	1.2	1.2	-1.2	1.2	-1.2	0.8
Bone: trabecular tissue density	1.4	2.0	2.4	-1.4	-1.4	1.4	-1.4	1.4	-1.5
Water consumed over 24 hours	1.3	1.8	2.1	-1.4	-1.3	1.3	-1.3	1.3	-1.5
Number of responses in last shaping day	0.6	0.6	0.7	-0.8	-0.8	0.8	-0.8	0.8	-0.8