Eif1ad

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Eif1ad	0.03	0.02	5.3e-03	0.02	0.01	0.01	0.01	1.7e-03	4.7e-02	1.8e-02	1.8e-02
2	Liver	alternative polyA	NM_001008305.1	0.59	0.1	0.0e+00	0.08	0.19	0.18	0.16	5.6e-09	6.2e-21	4.8e-20	9.2e-18
3	Liver	alternative polyA	XM_039108337.2	0.56	0.11	0.0e+00	0.07	0.17	0.16	0.14	1.6e-08	2.2e-18	2.3e-17	6.0e-15
4	Liver	isoform ratio	NM_001008305.1	0.21	0.1	5.6e-03	-0	0.02	0.02	-0	4.6e-01	5.6e-03	1.0e-03	4.4e-01
5	Liver	isoform ratio	XM_039108337.2	0.25	0.11	1.3e-03	-0	0.03	0.03	0	4.3e-01	7.2e-04	3.2e-04	1.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.5	-0.7	-0.6	0.5	0.6	-0.2
Area under the delay curve	0.1	0.2	0.5	0.2	0.4	-0.5	0.7	-0.3
BMI with tail	0.4	1.4	5.7	-2.4	-0.7	0.4	0.8	0.5
BMI without tail	0.1	0.8	3.0	-1.7	-0.4	0.1	0.2	0.9
Body weight	1.2	5.2	12.7	-3.6	-2.6	2.4	0.6	-0.0
Weight adjusted by age	0.4	1.2	2.6	-1.6	-1.2	1.3	0.1	-0.4
Bone surface	3.3	6.4	7.9	-2.8	-2.8	2.8	2.1	-2.0
Bone volume	0.7	1.3	2.1	-1.5	-1.4	1.4	0.4	-0.5
Breakpoint value in progressive ratio session	0.9	1.7	4.0	-2.0	-1.5	1.6	0.1	-0.2
Number of licking bursts	0.1	0.4	0.6	-0.8	-0.6	0.6	0.6	-0.4
Context. condit. distance diff. score	2.5	3.1	3.6	1.7	1.8	-1.9	-1.7	1.6
Locomotion velocity, session 1	0.3	0.4	1.2	-0.2	-0.3	0.2	1.1	-0.8
Locomotion distance, session 1	0.4	0.5	1.1	-0.7	-0.6	0.4	1.0	-0.4
Locomotion velocity, session 2	1.1	1.3	3.0	-1.7	-1.3	1.2	0.1	0.2
Locomotion distance, session 2	0.3	0.4	0.9	-0.9	-0.8	0.6	-0.3	0.5
Locomotion velocity, session 3	1.1	1.3	2.4	0.5	0.9	-1.0	-1.4	1.5
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.3	0.3
Stereotopy head waving bouts, day 3	1.9	2.2	3.8	1.3	1.1	-1.2	-1.9	1.8
Stereotopy head waving duration, day 3	1.0	1.2	2.3	1.5	0.8	-0.9	-1.3	0.9
Locomotion velocity, session 7	3.7	4.0	8.4	0.5	1.7	-1.8	-2.4	2.9
Locomotion distance, session 7	0.6	0.8	2.2	0.0	0.6	-0.8	-0.9	1.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.3	0.5	-0.4	-0.4	0.3
Stereotopy head waving duration, day 7	0.1	0.2	0.5	-0.7	-0.4	0.5	0.0	-0.1
Locomotion velocity, session 8	1.2	1.5	2.2	-1.1	-1.5	1.3	1.0	-1.1
Locomotion distance, session 8	1.2	1.8	3.2	0.6	1.0	-1.2	-1.8	1.7
Degree of sensitization distance	0.2	0.2	0.6	0.1	0.4	-0.5	-0.2	0.8
Degree of sensitization stereotypy	0.1	0.1	0.4	-0.7	0.0	0.2	0.1	-0.1
Conditioned locomotion	0.8	0.9	2.1	-1.5	-1.1	1.0	0.4	-0.3
Cocaine response after cond. corrected	0.9	1.4	2.3	1.3	1.4	-1.5	-0.5	0.8
Cocaine response after cond. not corrected	0.5	0.8	1.3	1.1	1.1	-1.2	0.0	0.3
Cocaine response before conditioning	0.7	0.9	1.3	-1.1	-1.0	1.1	0.6	-0.7
Saline control response	3.8	5.2	7.2	-2.2	-2.7	2.5	2.1	-1.7
Bone: connectivity density	2.0	3.2	4.2	-2.1	-1.8	1.7	2.0	-1.4
Bone: cortical apparent density	0.1	0.1	0.4	-0.6	-0.2	0.2	0.3	-0.2
Bone: cortical area	0.3	0.4	1.3	-1.1	-0.6	0.6	-0.3	0.0
Bone: cortical porosity	0.2	0.2	0.5	-0.2	-0.7	0.6	-0.0	0.1
Bone: cortical porosity	0.4	0.5	1.1	-0.5	-1.1	0.9	-0.2	0.1
Bone: cortical thickness	1.4	2.4	6.7	-2.6	-1.6	1.6	0.4	-0.3
Bone: cortical thickness	0.3	0.3	0.8	-0.9	-0.7	0.6	0.3	-0.1
Bone: cortical tissue density	0.2	0.2	0.6	-0.8	-0.4	0.4	0.4	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.8	-0.9	0.2	-0.2	0.1	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.4	-0.6	0.2	-0.2	0.5	-0.1
Condit. Reinf. active responses	0.7	0.9	1.8	-0.7	0.8	-0.8	-1.1	1.3
Condit. Reinf. inactive responses	1.5	1.9	4.1	0.1	0.9	-0.9	-2.0	1.9
Incentive salience index mean	0.3	0.4	0.9	-1.0	0.3	-0.4	-0.4	0.9
Condit. Reinf. lever presses	0.3	0.5	0.9	-0.9	0.2	-0.1	-0.8	1.0
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	0.4	-0.1	0.3	-0.7	0.3
Condit. Reinf. active-inactive response ratio	0.8	1.3	2.9	0.9	0.9	-0.7	-1.7	1.2
Condit. Reinf. active responses	0.2	0.3	0.9	-0.1	-0.9	0.9	-0.1	-0.3
Condit. Reinf. inactive responses	1.0	1.5	1.9	-0.6	-1.4	1.2	1.4	-1.3
Condit. Reinf. lever presses	1.1	1.6	2.8	-1.6	-1.6	1.7	-0.5	0.0
Condit. Reinf. lever reinforcers received	0.5	0.7	1.7	-0.3	-1.2	1.3	-0.2	-0.3
Conditioned reinforcement - actives	0.1	0.3	1.2	0.3	-0.3	0.5	-1.1	0.0
Conditioned reinforcement - inactives	1.0	2.6	4.0	2.0	1.8	-1.5	-1.8	0.8
Conditioned locomotion	4.5	6.6	12.3	3.5	2.8	-2.7	-2.1	1.2
Patch foraging indifference point 0 sec	0.1	0.3	0.6	0.5	0.0	-0.0	0.8	-0.8
Patch foraging indifference point AUC	0.9	2.2	4.0	-1.9	-1.9	2.0	-0.2	-0.1
Delay disc. indifference point, 0s delay	1.0	1.1	1.6	1.2	0.9	-1.1	-0.7	1.3
Delay disc. indifference point, 16s delay	0.4	0.6	1.1	0.6	1.1	-0.9	0.5	-0.6
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	0.5	0.6	-0.6	-0.3	0.3
Delay disc. indifference point, 24s delay	0.3	0.5	1.4	0.0	0.0	-0.1	1.1	-1.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.4	0.3	-0.5	0.4	-0.0
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	0.3	0.2	-0.4	0.7	-0.3
Indifference point function ln k	3.5	10.7	15.2	3.9	3.6	-3.8	-2.3	2.4
Indifference point function log k	3.5	10.7	15.2	3.9	3.6	-3.8	-2.3	2.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	0.4	-0.1	0.1	0.6	-0.7
Patch foraging total patch changes 12 sec	2.3	3.1	5.3	-2.3	-2.2	2.1	0.7	-0.6
Patch foraging total patch changes 18 sec	0.3	0.7	1.3	-1.1	-0.8	0.8	0.9	-0.6
Patch foraging total patch changes 24 sec	0.8	2.6	4.4	-1.6	-2.1	2.1	0.8	-1.0
Patch foraging total patch changes 6 sec	0.8	1.3	2.1	-1.3	-1.1	1.0	1.4	-0.9
Patch foraging time to switch 0 sec	0.3	1.3	4.1	-2.0	-0.7	0.7	1.0	-0.5
Patch foraging water rate 0 sec	1.0	3.9	8.8	3.0	1.9	-1.8	-1.7	1.1
Patch foraging water rate 12 sec	1.4	5.8	17.3	4.2	2.3	-2.4	-0.6	0.2
Patch foraging water rate 18 sec	1.1	2.4	5.5	2.3	1.7	-1.8	-0.1	0.3
Patch foraging water rate 24 sec	2.3	3.2	7.3	2.7	2.0	-2.0	-0.6	0.5
Patch foraging water rate 6 sec	2.0	3.0	7.5	2.7	1.6	-1.8	-0.7	0.9
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	0.0	0.6	-0.6	-0.1	0.5
Distance traveled before self-admin	0.1	0.2	0.4	-0.5	-0.5	0.6	-0.1	-0.1
Distance traveled after self-admin	0.1	0.2	0.5	-0.2	-0.7	0.7	-0.2	-0.2
Extensor digitorum longus weight	3.4	13.5	35.3	-5.9	-4.1	3.9	0.6	-0.3
Bone: elastic displacement	0.3	0.3	0.6	0.7	0.7	-0.7	0.1	0.3
Bone: elastic work	0.4	0.6	1.5	-1.2	-0.8	0.6	0.6	-0.0
Bone: endosteal estimation	0.5	1.2	2.6	1.6	1.2	-1.2	-0.6	0.6
Bone: endosteal perimeter	0.5	1.3	3.1	1.8	1.3	-1.2	-0.2	-0.0
Epididymis fat weight	1.6	8.0	14.3	3.8	3.1	-3.0	-2.2	1.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.2	-0.3	0.1	0.1	0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.4	-0.3	0.5	-0.2	-0.3
Diff in mean of infusions in LGA sessions	0.4	0.7	1.2	-1.1	-0.7	0.8	0.7	-0.8
Delay discount exponential model param	0.1	0.2	0.5	-0.1	-0.2	0.3	-0.7	0.4
Extinction: sum of active levers before priming	0.6	0.9	2.4	-1.6	-1.0	1.0	0.2	0.0
Active lever presses in extinction session 6	2.0	2.0	3.9	-1.7	-1.8	2.0	0.2	-0.5
Bone: final force	1.2	1.9	3.5	-1.9	-1.7	1.7	0.1	-0.5
Bone: final moment	1.1	1.7	3.1	-1.8	-1.7	1.6	0.1	-0.4
Food consumed during 24 hour testing period	0.2	0.4	1.5	0.1	-0.4	0.6	-1.2	0.3
Glucose	1.9	3.0	5.1	1.9	2.1	-2.3	-0.7	1.2
Heart weight	1.1	1.8	3.2	1.0	1.5	-1.8	1.5	-0.2
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.2	-0.3	0.4	-0.5	0.2
Intermittent access intake day 1-15 change	0.2	1.4	1.9	1.3	1.2	-1.0	-1.4	0.7
Intermittent access intake escalation	0.2	0.9	1.2	1.1	1.1	-0.8	-1.1	0.4
Intermittent access intake escalation 2	0.5	0.8	1.5	1.2	1.0	-0.8	-1.0	0.2
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	0.1	0.6	-0.4	-0.2	-0.0
Intermitt. access day 15 inactive lever presses	0.5	2.6	3.7	1.2	1.9	-1.7	-1.7	1.5
Intermitt. access escalation Index	1.1	3.3	5.4	2.3	1.9	-2.1	-1.1	1.3
Intermittent access day 1 total infusions	1.1	3.2	5.6	1.8	2.4	-2.4	-0.8	1.1
Intermittent access day 15 total infusions	2.1	5.1	8.5	2.4	2.9	-2.7	-1.6	1.2
Intermittent access terminal intake (last 3 days)	2.3	4.1	7.5	2.1	2.7	-2.5	-1.2	0.8
Intermittent access total infusions	3.1	3.6	6.4	1.8	2.5	-2.4	-1.1	1.1
Intermittent access day 1 locomotion	1.1	1.9	4.0	1.2	2.0	-2.0	-0.2	0.6
Intermittent access day 15 total locomotion	1.3	4.9	7.7	2.1	2.8	-2.5	-2.0	1.4
Intermittent access total locomotion	6.6	8.0	12.2	2.7	3.5	-3.3	-2.3	2.0
Intermittent access standard deviation	0.2	0.9	1.7	1.3	1.2	-1.1	-0.3	0.1
Left kidney weight	1.2	9.3	15.9	2.4	2.5	-2.6	-4.0	3.4
Right kidney weight	0.6	4.5	9.9	1.7	1.4	-1.4	-3.2	2.3
Cocaine induced anxiety	0.2	0.5	1.7	-0.1	-0.2	0.2	-1.3	0.9
Post-drug Anxiety	1.1	1.2	2.6	-0.6	-1.0	1.0	-1.6	1.0
Baseline Anxiety	0.2	0.4	0.9	-0.2	-1.0	0.9	-0.4	0.1
Tail length	0.2	1.3	2.6	-1.3	-1.6	1.5	0.2	-0.3
Length with tail	1.4	6.0	9.7	-2.9	-3.1	3.0	1.2	-1.2
Length without tail	1.2	6.5	9.4	-2.5	-3.1	3.0	2.0	-2.0
Times rat made contact with spout	0.5	0.6	0.9	-0.7	-0.8	0.7	1.0	-0.6
Lifetime Intake	2.2	2.8	4.8	1.6	2.2	-2.2	-0.9	1.0
Liver weight, left	0.5	0.9	1.6	1.3	1.1	-1.2	-0.5	0.6
Liver weight, right	1.0	1.8	3.3	1.8	1.6	-1.8	0.1	0.2
Locomotor activity	0.8	1.3	2.7	1.6	1.2	-1.3	0.7	-0.4
Locomotor testing distance	0.7	1.7	3.2	1.8	1.1	-1.3	1.3	-0.9
Locomotor testing rearing	0.8	2.9	6.1	1.8	0.5	-0.7	2.5	-2.1
Locomotion in novel chamber	3.1	4.1	7.5	2.7	2.5	-2.4	-0.9	0.6
Locomotion in novel chamber post-restriction	1.0	3.0	4.9	2.2	2.2	-2.1	-0.9	0.6
Fecal boli incidents, locomotor time 1	0.1	0.4	1.2	-0.2	0.3	-0.0	-1.1	0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.8	0.1	-0.3	0.1	0.9	-0.6
Time >=10cm from walls, locomotor time 1	1.1	1.3	2.2	0.7	1.5	-1.3	-0.9	1.3
Bouts of movement, locomotor time 1	1.7	2.2	3.2	-1.8	-1.5	1.7	1.2	-1.2
Total resting periods, locomotor time 1	1.2	1.4	2.2	-1.5	-1.2	1.4	0.8	-0.9
Rest time, locomotor task time 1	0.8	1.3	2.4	1.5	1.2	-1.1	-1.0	0.7
Distance moved, locomotor task time 1	0.0	0.1	0.3	-0.3	0.3	-0.4	-0.1	0.6
Vertical activity count, locomotor time 1	0.2	1.1	1.5	0.8	1.2	-1.2	-1.0	0.9
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.6	-0.1	0.2	-0.1	-0.7	0.8
Bouts of movement, locomotor time 2	0.6	2.1	3.5	-1.2	-1.0	1.1	1.8	-1.9
Total resting periods, locomotor time 2	0.3	1.3	2.4	-0.9	-0.7	0.8	1.5	-1.5
Rest time, locomotor task time 2	1.6	2.8	3.5	1.9	1.7	-1.7	-1.6	1.4
Distance moved, locomotor task time 2	0.5	0.6	1.5	-1.2	-0.9	0.9	0.4	-0.2
Vertical activity count, locomotor time 2	0.0	0.1	0.3	-0.2	-0.1	0.1	-0.5	0.4
Light reinforcement 1	0.0	0.2	0.4	0.6	-0.3	0.3	0.3	-0.5
Light reinforcement 2	0.3	0.7	0.9	0.9	1.0	-0.8	-0.8	0.4
Bone: marrow area	0.6	1.4	2.8	1.7	1.3	-1.3	-0.6	0.6
Bone: maximum diameter	0.2	0.3	0.7	-0.4	-0.5	0.7	0.1	-0.9
Bone: maximum force	1.2	2.4	5.8	-2.4	-1.7	1.7	0.6	-0.5
Bone: maximum moment	1.1	2.2	5.1	-2.3	-1.6	1.6	0.5	-0.4
Mean time between licks in bursts	0.2	1.3	2.4	-0.6	-1.1	1.0	1.6	-1.3
Mean num. licks in bursts	0.0	0.1	0.4	0.6	0.3	-0.4	-0.0	0.1
Cd content in liver	0.8	0.9	1.9	1.4	0.8	-0.6	-1.1	0.6
Co content in liver	0.9	1.0	1.8	1.3	0.7	-0.9	-1.0	0.9
Cu content in liver	0.5	0.6	1.3	0.2	0.7	-0.7	-0.9	1.1
Fe content in liver	0.3	0.3	0.4	-0.5	-0.6	0.6	0.6	-0.6
K content in liver	0.1	0.1	0.3	-0.6	-0.2	0.1	0.2	0.3
Mg content in liver	0.4	0.4	0.7	0.7	0.7	-0.8	0.1	0.5
Mn content in liver	2.5	2.8	5.6	-2.4	-1.6	1.8	1.0	-1.1
Na content in liver	0.2	0.3	0.6	-0.4	-0.7	0.7	0.1	-0.2
Rb content in liver	1.0	1.2	2.2	1.5	1.2	-1.3	0.7	-0.1
Se content in liver	0.1	0.1	0.1	0.3	0.4	-0.2	-0.3	0.0
Sr content in liver	2.3	2.0	3.4	-1.6	-1.8	1.8	0.6	-0.9
Zn content in liver	0.1	0.1	0.3	-0.4	-0.1	0.0	-0.2	0.5
Bone: minimum diameter	0.8	1.6	2.5	1.2	1.5	-1.6	-0.7	1.1
Time in familiar zone, hab. session 1	0.3	0.4	0.5	0.5	0.7	-0.7	-0.5	0.6
Time in novel zone, hab. session 1	0.3	0.3	0.8	0.3	-0.2	0.2	0.8	-0.9
Total zone transitions, hab. session 1	0.3	0.4	1.6	-1.2	-0.5	0.4	-0.1	0.3
Total locomotion distance, hab. session 1	0.9	1.3	2.1	0.8	1.1	-1.1	-1.2	1.5
Locomotion velocity, hab. session 1	0.5	0.7	1.4	0.2	0.6	-0.7	-1.0	1.2
Time in familiar zone, hab. session 2	1.0	1.1	3.0	-0.3	-0.3	0.2	1.7	-1.5
Time in novel zone, hab. session 2	0.6	0.7	1.8	0.1	-0.1	0.1	-1.3	1.2
Total zone transitions, hab. session 2	1.8	2.3	4.7	-1.3	-1.4	1.2	2.2	-1.3
Total locomotion distance, hab. session 2	0.1	0.2	0.6	0.1	0.2	-0.4	0.8	0.0
Locomotion velocity, hab. session 2	0.1	0.2	0.4	0.2	0.5	-0.6	0.5	0.2
Novel to familiar place preference ratio	0.5	0.7	1.0	-0.8	-0.8	1.0	0.5	-0.8
Novelty place preference	0.3	0.4	0.6	-0.4	-0.5	0.7	0.5	-0.8
Time in novel zone, NPP test	0.2	0.3	0.4	-0.3	-0.5	0.7	0.4	-0.6
Total zone transitions, NPP test	1.0	1.5	2.8	-1.6	-1.7	1.5	0.1	-0.0
Total locomotion distance, NPP test	0.8	1.1	2.9	0.1	0.2	-0.4	-1.6	1.7
Locomotion velocity, NPP test	0.7	1.1	2.8	-0.0	0.2	-0.4	-1.5	1.7
Intraocular pressure	0.3	0.5	1.0	1.0	0.7	-0.4	-0.7	-0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.2	0.4	-0.1	0.1	-0.2	-0.0
Delta ambulatory time before/after self-admin	0.0	0.1	0.2	0.3	-0.4	0.3	-0.2	0.0
Parametrial fat weight	3.9	9.3	11.8	3.3	3.4	-3.4	-2.6	2.3
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.4	0.1	-0.0	0.6	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.5	-0.0	0.0	-0.1	0.4
Pavlov. Cond. change in total contacts	0.5	0.5	1.1	-0.3	0.6	-0.4	-1.0	0.9
Pavlov. Cond. index score	0.1	0.1	0.2	-0.5	-0.2	0.2	-0.3	0.3
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.3	-0.0	0.0	-0.4	0.5
Pavlov. Cond. lever contacts	0.4	0.4	1.2	-0.2	0.2	-0.3	-0.9	1.1
Pavlov. Cond. magazine entry number	0.1	0.2	0.5	0.7	0.3	-0.4	0.1	0.0
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	0.4	0.9	-0.8	-1.0	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	-0.6	-0.2	0.2	-0.5	0.5
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.5	-0.1	0.2	-0.7	0.5
Pavlov. Cond. lever latency	0.4	0.6	1.1	0.8	0.7	-0.7	1.0	-0.4
Pavlov. Cond. magazine entry latency	2.2	3.1	7.2	-2.7	-2.0	2.0	0.3	-0.2
Pavlov. Cond. change in total contacts	0.6	1.4	2.5	-1.6	-1.1	1.3	-1.1	0.5
Pavlov. Cond. index score	1.1	1.8	3.9	-2.0	-1.3	1.4	-0.9	0.5
Pavlov. Cond. latency score	0.9	1.5	3.7	-1.9	-1.1	1.2	-0.9	0.6
Pavlov. Cond. lever contacts	0.4	0.5	0.8	-0.8	-0.8	0.9	-0.8	0.2
Pavlov. Cond. magazine entry number	4.0	5.2	11.0	3.3	2.7	-2.8	-0.5	0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.5	1.6	1.3	0.8	-0.7	-0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.4	2.2	4.7	-2.2	-1.5	1.6	-0.8	0.5
Pavlov. Cond. response bias	1.1	1.5	2.8	-1.7	-1.4	1.5	-0.6	0.2
Time in closed arm before self-admin	0.0	0.1	0.1	0.3	0.3	-0.2	0.1	-0.2
Time in closed arm after self-admin	0.2	0.3	0.4	0.2	0.5	-0.5	-0.5	0.6
Time in open arm before self-admin	0.3	0.3	0.7	0.4	0.4	-0.8	0.8	-0.0
Time in open arm after self-admin	0.6	0.6	1.7	-0.2	-0.4	0.3	1.3	-1.1
Bone: periosteal estimation	0.1	0.2	0.5	0.2	0.5	-0.4	-0.7	0.5
Bone: periosteal perimeter	0.1	0.1	0.4	-0.2	-0.1	0.2	0.5	-0.6
Bone: post-yield work	0.2	0.4	0.8	-0.9	0.6	-0.5	0.4	0.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.5	0.3	0.7	-0.7	0.1	-0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.4	0.2	0.7	-0.6	0.1	-0.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.2	0.3	-0.2	-0.1	-0.0
Progressive ratio test 2 active lever presses	1.4	2.0	3.1	1.6	1.8	-1.6	-1.2	0.7
Progressive ratio test 2 breakpoint	1.5	1.9	3.0	1.5	1.7	-1.5	-1.2	0.6
Progressive ratio test 2 inactive lever presses	2.3	7.2	10.8	3.3	3.2	-2.9	-2.1	1.5
Incentive Sensitization - Responses	0.1	0.2	0.5	0.1	0.4	-0.3	-0.7	0.6
Incentive Sensitization - Breakpoint	0.2	0.4	0.6	0.3	0.6	-0.5	-0.8	0.7
Sum of active levers in priming session hrs 5-6	1.5	1.4	2.6	-0.8	-1.1	1.5	-1.6	0.3
Progressive ratio	0.1	0.3	1.0	-1.0	-0.3	0.3	0.7	-0.0
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.5	-0.2	0.2	0.2	0.0
Seeking ratio, punishment vs. effort	0.2	0.5	1.5	1.2	0.6	-0.7	-0.4	0.2
Retroperitoneal fat weight	6.0	27.0	48.7	7.0	6.1	-6.2	-2.4	2.1
Reaction time number correct	0.1	0.4	0.9	-0.2	-1.0	1.0	-0.4	0.4
Reaction time mean minus median	0.5	3.3	8.0	-2.8	-1.7	1.8	1.1	-1.0
Reaction time mean minus median AUC	0.3	2.3	5.2	-2.3	-1.3	1.5	1.2	-1.0
Reaction time num false alarms	0.9	1.5	2.8	0.7	1.1	-1.3	-1.2	1.7
Reaction time num false alarms AUC	0.3	0.8	2.2	-0.1	0.6	-0.8	-0.8	1.5
Reaction time trials correct on left	0.1	0.4	0.9	-0.2	-1.0	1.0	-0.4	0.4
Reaction time trials on left	0.1	0.5	1.1	-0.3	-1.0	1.0	-0.4	0.3
Reaction time mean	0.1	0.2	0.4	-0.7	-0.2	0.3	0.2	-0.4
Reaction time mean AUC	0.0	0.1	0.4	-0.6	0.0	0.1	0.2	-0.4
Median of all reaction times	0.0	0.0	0.1	0.1	0.3	-0.2	-0.2	-0.1
Reaction time omissions	1.1	1.7	4.3	-2.1	-1.2	1.2	1.0	-0.8
Reaction time false alarm rate	0.8	1.1	2.1	0.3	1.3	-1.4	-0.6	1.2
Reaction time premature initiation rate	3.1	4.7	6.9	-2.0	-2.2	2.0	2.6	-2.0
Reaction time premature initiations	2.0	6.0	8.3	-2.3	-2.9	2.7	2.3	-1.9
Std. dev. reaction times	0.5	1.6	3.1	-1.8	-1.1	1.2	1.0	-1.1
Reaction time trials completed	0.1	0.5	1.1	-0.3	-1.0	1.0	-0.4	0.3
Reaction time trials AUC	0.1	0.4	0.8	-0.1	-0.9	0.9	-0.6	0.5
Run reversals in cocaine runway, females	0.3	0.3	1.0	-0.6	0.2	-0.4	0.3	1.0
Run reversals in cocaine runway, males	0.3	0.3	0.7	0.4	0.5	-0.4	-0.8	0.4
Latency to leave start box in cocaine runway	0.3	0.4	0.9	-0.1	0.9	-0.9	0.5	-0.0
Latency to leave start box in cocaine runway, F	0.3	0.4	0.7	-0.1	0.7	-0.8	0.7	-0.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.4	0.2	-0.1	-0.1	0.2
Std. dev. time between licks in bursts	0.1	0.1	0.3	0.4	-0.1	-0.1	-0.4	0.5
Total sessions with >9 infusions	0.1	0.1	0.3	-0.2	0.6	-0.6	0.1	0.2
Short access day 1 total inactive lever presses	1.2	2.5	3.6	1.9	1.9	-1.9	-1.0	0.8
Short access day 10 total inactive lever presses	0.1	0.4	1.0	0.3	1.0	-1.0	0.0	0.4
Short access day 1 total infusions	1.0	2.0	3.8	1.2	1.9	-2.0	-0.7	0.7
Short access day 10 total infusions	0.7	1.2	2.6	0.4	1.6	-1.6	-0.3	0.9
Short access total infusions	0.8	1.1	2.1	0.5	1.4	-1.4	-0.6	1.0
Short access day 1 locomotion	0.9	1.5	3.4	0.8	1.8	-1.8	0.2	-0.0
Short access day 10 total locomotion	0.4	1.5	3.2	0.9	1.8	-1.7	-0.5	0.8
Short access total locomotion	1.1	1.7	3.6	1.0	1.9	-1.8	-0.4	0.7
One hour access (0.3 mA shock)	3.6	4.3	7.6	2.5	2.8	-2.6	-0.5	0.5
Compulsive drug intake	1.6	2.3	3.6	-1.4	-1.9	1.7	1.5	-1.1
One hour access (shock baseline)	2.6	6.8	10.7	2.9	3.3	-3.0	-1.8	1.5
Social response proportion	1.7	2.1	2.8	-1.0	-1.4	1.5	1.7	-1.7
Social responses	0.9	1.1	1.8	-0.6	-1.0	1.0	1.3	-1.3
Social time	1.0	1.6	2.4	-0.7	-1.3	1.2	1.5	-1.5
Soleus weight	4.5	13.1	17.4	4.2	3.7	-3.7	-3.3	3.1
Bone: stiffness	1.4	2.5	4.0	-2.0	-1.7	1.8	0.9	-1.1
Tibialis anterior weight	5.3	18.1	39.3	-6.3	-5.0	5.0	0.7	-0.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.8	-0.3	-0.2	0.1	0.9	-0.3
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.6	-0.8	0.0	-0.2	0.6	0.3
Time to tail flick, test, before self-admin	2.4	2.7	5.1	1.1	2.1	-2.3	-0.7	1.5
Time to tail flick, test, after self-admin	0.4	0.4	0.9	-0.3	-0.4	0.6	0.8	-0.9
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	-0.8	-0.3	0.2	0.4	-0.1
Delta time to tail flick, test, before/after SA	3.2	3.9	6.4	-1.3	-2.3	2.5	1.3	-2.1
Tibia length	0.8	2.1	3.2	-1.8	-1.4	1.7	-1.5	0.5
Ambulatory time before self-admin	0.1	0.2	0.3	-0.5	-0.4	0.5	0.1	-0.2
Ambulatory time after self-admin	0.1	0.2	0.5	0.7	0.3	-0.2	-0.6	0.3
Bone: tissue strength	0.0	0.0	0.1	-0.1	-0.0	0.1	0.3	-0.3
Total heroin consumption	3.2	3.7	5.7	-2.2	-2.3	2.4	1.0	-1.2
Bone: trabecular number	0.4	0.7	1.3	-1.1	-0.9	0.9	0.6	-0.5
Bone: trabecular spacing	0.2	0.3	0.8	0.9	0.5	-0.6	-0.3	0.4
Bone: trabecular thickness	0.2	0.2	0.4	0.6	0.6	-0.6	0.1	0.2
Bone: trabecular tissue density	3.6	6.3	7.6	2.5	2.8	-2.6	-2.7	2.0
Water consumed over 24 hours	1.1	2.1	2.4	-1.1	-1.6	1.5	1.5	-1.5
Number of responses in last shaping day	0.2	0.3	0.8	0.1	-0.4	0.3	0.5	-0.9