Eif1ad

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	XM_039108337.1	0.62	0.1	0.0e+00	0.1	0.2	0.18	0.17	1.6e-11	1.4e-21	6.2e-20	3.9e-18
2	Adipose	gene expression	Eif1ad	0.03	0.02	5.6e-03	0.02	0.01	0	0.01	1.9e-03	6.1e-02	2.4e-01	1.9e-02
3	Liver	alternative polyA	NM_001008305.1	0.63	0.11	0.0e+00	0.1	0.2	0.19	0.17	3.2e-11	3.6e-22	2.1e-20	4.9e-19
4	Liver	isoform ratio	XM_039108337.1	0.26	0.12	1.0e-03	-0	0.03	0.04	0.01	4.4e-01	3.7e-04	9.9e-06	4.3e-02
5	Liver	isoform ratio	NM_001008305.1	0.19	0.1	9.4e-03	-0	0.01	0.03	0	5.7e-01	2.9e-02	1.2e-04	2.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.3	0.6	0.8	0.7	-0.8	-0.6	0.9	-0.8
Area under the delay curve	0.1	0.1	0.2	-0.4	0.3	0.3	-0.2	0.3
BMI with tail	2.2	7.3	13.9	1.6	-2.5	-1.4	3.7	-3.4
BMI without tail	1.6	3.2	7.3	0.8	-1.2	-0.8	2.7	-2.5
Body weight	1.9	8.0	16.7	3.5	-4.1	-3.3	0.3	-0.1
Weight adjusted by age	1.4	1.5	3.5	1.5	-1.9	-1.3	-0.0	0.0
Bone surface	2.8	4.9	9.1	3.0	-2.8	-2.8	-0.1	0.1
Bone volume	0.9	1.6	2.6	1.6	-1.6	-1.4	0.7	-0.7
Breakpoint value in progressive ratio session	1.8	2.0	3.9	1.8	-2.0	-1.7	0.0	-0.0
Number of licking bursts	0.3	0.3	0.6	0.7	-0.7	-0.7	-0.1	0.1
Context. condit. distance diff. score	2.0	2.5	3.8	-1.9	1.7	1.9	1.1	-1.0
Locomotion velocity, session 1	0.2	0.2	0.4	0.1	-0.0	-0.3	-0.6	0.6
Locomotion distance, session 1	0.3	0.3	0.6	0.6	-0.8	-0.7	0.4	-0.2
Locomotion velocity, session 2	1.3	1.5	3.9	1.4	-2.0	-1.3	0.1	0.1
Locomotion distance, session 2	0.3	0.5	1.2	0.7	-1.1	-0.7	0.2	-0.0
Locomotion velocity, session 3	0.8	0.9	1.6	-0.9	0.3	0.9	1.3	-1.1
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	0.1	0.4	0.0	0.0
Stereotopy head waving bouts, day 3	1.0	1.2	1.7	-0.9	1.0	0.8	1.3	-1.3
Stereotopy head waving duration, day 3	0.8	1.0	1.4	-0.7	1.2	0.7	1.1	-1.2
Locomotion velocity, session 7	3.0	3.3	5.7	-1.7	0.5	1.7	2.4	-2.2
Locomotion distance, session 7	0.6	0.8	1.3	-0.9	0.1	0.9	1.1	-0.9
Stereotopy head waving bouts, day 7	0.4	0.4	0.8	-0.3	0.5	0.4	0.9	-0.9
Stereotopy head waving duration, day 7	0.6	0.8	1.4	1.2	-1.0	-1.1	0.4	-0.3
Locomotion velocity, session 8	1.6	2.0	2.6	1.3	-1.1	-1.4	-1.5	1.6
Locomotion distance, session 8	0.9	1.3	2.1	-1.0	0.5	1.0	1.4	-1.4
Degree of sensitization distance	0.4	0.4	0.9	-0.5	0.0	0.5	0.9	-0.8
Degree of sensitization stereotypy	0.3	0.3	0.5	0.7	-0.7	-0.5	0.5	-0.5
Conditioned locomotion	0.9	1.1	2.5	1.2	-1.6	-1.2	-0.4	0.4
Cocaine response after cond. corrected	0.8	0.9	1.8	-1.3	1.3	1.2	-0.1	0.1
Cocaine response after cond. not corrected	0.5	0.6	1.2	-0.9	1.1	0.8	-0.3	0.4
Cocaine response before conditioning	0.7	0.9	1.6	1.3	-1.0	-1.1	-0.5	0.5
Saline control response	3.9	5.1	8.0	2.8	-2.3	-2.8	-1.4	1.5
Bone: connectivity density	1.4	2.2	3.9	2.0	-1.9	-1.9	0.3	-0.2
Bone: cortical apparent density	0.1	0.2	0.3	0.4	-0.6	-0.5	-0.1	0.2
Bone: cortical area	0.3	0.4	1.6	0.6	-1.3	-0.5	0.0	-0.0
Bone: cortical porosity	0.3	0.3	0.8	0.3	-0.2	-0.3	0.9	-0.8
Bone: cortical porosity	0.5	0.5	0.8	0.9	-0.7	-0.9	0.6	-0.5
Bone: cortical thickness	2.0	3.2	6.8	1.5	-2.6	-1.5	-1.5	1.6
Bone: cortical thickness	1.4	1.6	3.2	0.5	-1.2	-0.7	-1.6	1.8
Bone: cortical tissue density	0.2	0.3	0.4	0.6	-0.6	-0.6	-0.3	0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.3	-0.7	-0.3	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.4	0.4
Condit. Reinf. active responses	0.2	0.2	0.5	-0.2	-0.5	0.3	0.7	-0.6
Condit. Reinf. inactive responses	0.9	1.0	2.1	-0.7	0.1	0.8	1.4	-1.4
Incentive salience index mean	0.3	0.3	0.7	0.3	-0.9	-0.2	0.6	-0.5
Condit. Reinf. lever presses	0.3	0.4	0.7	0.4	-0.8	-0.3	0.7	-0.6
Condit. Reinf. active minus inactive responses	0.0	0.1	0.1	-0.2	0.3	0.4	-0.0	-0.0
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.7	-1.1	0.8	1.3	1.0	-1.1
Condit. Reinf. active responses	0.1	0.2	0.2	0.4	-0.3	-0.4	-0.4	0.4
Condit. Reinf. inactive responses	0.8	1.0	1.4	1.1	-0.7	-1.2	-0.9	1.1
Condit. Reinf. lever presses	1.6	2.2	4.2	1.8	-2.0	-1.6	-0.8	0.8
Condit. Reinf. lever reinforcers received	0.4	0.5	0.8	0.9	-0.6	-0.8	-0.6	0.7
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.3	0.5	0.3	-0.3	0.2
Conditioned reinforcement - inactives	3.9	4.4	7.4	-2.7	2.7	2.7	-0.3	0.1
Conditioned locomotion	5.2	6.2	11.7	-3.2	3.4	3.1	-0.2	-0.0
Patch foraging indifference point 0 sec	0.0	0.1	0.1	0.1	0.3	-0.1	-0.3	0.3
Patch foraging indifference point AUC	1.9	2.2	3.9	2.0	-1.9	-1.9	-0.2	0.2
Delay disc. indifference point, 0s delay	0.8	0.9	1.4	-1.1	1.2	0.9	0.7	-0.6
Delay disc. indifference point, 16s delay	0.5	0.5	1.2	-1.0	0.6	1.1	-0.0	0.0
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	-0.5	0.5	0.4	0.3	-0.3
Delay disc. indifference point, 24s delay	0.5	0.5	1.4	-0.1	-0.0	-0.0	-1.1	1.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	-0.5	0.5	0.4	-0.4	0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	-0.2	0.3	0.1	-0.7	0.8
Indifference point function ln k	5.7	8.0	13.6	-3.7	3.6	3.4	0.8	-0.8
Indifference point function log k	5.7	8.0	13.6	-3.7	3.6	3.4	0.8	-0.8
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.1	0.2	-0.2	-0.7	0.7
Patch foraging total patch changes 12 sec	2.8	3.6	6.0	2.5	-2.4	-2.4	-0.5	0.6
Patch foraging total patch changes 18 sec	0.3	0.3	0.6	0.7	-0.8	-0.7	-0.2	0.2
Patch foraging total patch changes 24 sec	2.5	3.1	4.3	2.1	-1.7	-2.1	-1.4	1.4
Patch foraging total patch changes 6 sec	0.8	1.2	1.7	1.2	-1.3	-1.3	-0.7	0.9
Patch foraging time to switch 0 sec	1.0	1.6	4.2	1.2	-2.1	-1.0	0.9	-0.7
Patch foraging water rate 0 sec	2.2	3.5	8.2	-2.2	2.9	2.0	-0.5	0.3
Patch foraging water rate 12 sec	4.0	6.2	14.6	-3.0	3.8	2.6	-0.7	0.5
Patch foraging water rate 18 sec	2.0	2.7	4.6	-2.2	2.0	1.9	-0.7	0.7
Patch foraging water rate 24 sec	2.4	3.3	6.5	-2.3	2.6	2.1	-0.0	-0.1
Patch foraging water rate 6 sec	2.1	3.0	5.1	-2.1	2.3	1.8	-1.1	1.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	-0.3	-0.0	0.4	0.3	-0.3
Distance traveled before self-admin	0.5	0.5	0.7	0.8	-0.5	-0.7	0.7	-0.8
Distance traveled after self-admin	0.2	0.3	0.4	0.6	-0.2	-0.5	0.5	-0.7
Extensor digitorum longus weight	4.3	16.8	36.1	4.9	-6.0	-4.8	-0.7	1.0
Bone: elastic displacement	1.1	1.3	2.2	-1.0	0.8	0.7	-1.4	1.5
Bone: elastic work	1.2	1.5	2.7	0.7	-1.1	-1.0	-1.5	1.7
Bone: endosteal estimation	1.3	2.9	4.6	-1.2	1.5	1.3	2.1	-2.1
Bone: endosteal perimeter	1.2	2.4	3.8	-1.0	1.6	1.1	1.9	-2.0
Epididymis fat weight	2.2	5.1	8.4	-2.6	2.9	2.6	1.4	-1.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	-0.1	-0.1	-0.1	-0.7	0.8
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.3	-0.1	-0.2	0.2	-0.4
Diff in mean of infusions in LGA sessions	0.8	0.9	1.2	0.8	-0.8	-0.9	-1.1	1.1
Delay discount exponential model param	0.1	0.1	0.2	0.3	-0.2	-0.3	0.3	-0.4
Extinction: sum of active levers before priming	2.7	2.7	4.6	2.0	-2.1	-1.8	1.1	-1.0
Active lever presses in extinction session 6	1.7	1.7	3.4	1.8	-1.4	-1.7	-0.2	0.0
Bone: final force	1.6	2.6	5.1	2.0	-2.3	-1.9	-0.1	0.1
Bone: final moment	1.4	2.3	4.5	1.9	-2.1	-1.8	-0.1	0.1
Food consumed during 24 hour testing period	0.6	0.7	1.5	0.5	-0.4	-0.4	-1.2	1.1
Glucose	2.1	3.1	3.2	-1.8	1.7	1.8	1.8	-1.8
Heart weight	2.0	2.8	5.1	-2.3	2.0	2.1	-0.3	0.5
Delay discount hyperbolic model param	0.1	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.3
Intermittent access intake day 1-15 change	0.4	0.4	0.6	-0.7	0.5	0.8	-0.6	0.5
Intermittent access intake escalation	0.4	0.4	0.8	-0.8	0.6	0.9	-0.3	0.2
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.3	0.5	0.3	-0.2	0.0
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.8	-1.7	1.4	1.7	0.0	-0.1
Intermitt. access day 15 inactive lever presses	1.8	1.9	4.0	-1.9	1.4	2.0	-0.3	0.2
Intermitt. access escalation Index	3.3	2.9	5.1	-2.3	2.1	2.1	0.6	-0.5
Intermittent access day 1 total infusions	4.7	5.4	9.0	-3.0	2.6	3.0	1.1	-1.0
Intermittent access day 15 total infusions	5.6	6.3	11.8	-3.4	2.8	3.4	0.1	-0.1
Intermittent access terminal intake (last 3 days)	4.0	4.3	8.4	-2.8	2.3	2.9	0.2	-0.2
Intermittent access total infusions	3.7	4.1	8.2	-2.8	2.0	2.9	0.5	-0.4
Intermittent access day 1 locomotion	3.4	3.6	6.7	-2.6	1.8	2.6	0.9	-0.7
Intermittent access day 15 total locomotion	3.7	4.0	7.9	-2.7	2.1	2.8	0.2	-0.2
Intermittent access total locomotion	5.8	6.6	11.9	-3.3	2.7	3.4	1.3	-1.2
Intermittent access standard deviation	0.8	0.8	1.5	-1.2	1.0	1.2	-0.4	0.3
Left kidney weight	1.0	2.9	4.1	-2.0	1.3	2.0	1.5	-1.6
Right kidney weight	0.1	0.4	0.8	-0.8	0.5	0.9	0.2	-0.4
Cocaine induced anxiety	0.0	0.1	0.2	0.1	-0.0	-0.1	0.3	-0.4
Post-drug Anxiety	1.1	1.2	2.3	1.5	-1.2	-1.4	0.4	-0.5
Baseline Anxiety	1.5	1.6	2.8	1.7	-1.5	-1.7	-0.3	0.3
Tail length	1.0	2.9	3.7	1.6	-1.5	-1.7	-1.9	1.9
Length with tail	2.5	9.1	10.5	3.0	-3.2	-3.0	-2.9	2.9
Length without tail	2.7	5.9	6.8	2.6	-2.6	-2.5	-2.2	2.2
Times rat made contact with spout	0.6	0.7	1.0	0.9	-0.9	-1.0	-0.6	0.8
Lifetime Intake	3.3	3.8	7.4	-2.7	1.9	2.7	0.5	-0.4
Liver weight, left	0.8	1.3	2.9	-0.5	0.6	0.5	1.6	-1.7
Liver weight, right	0.0	0.1	0.2	-0.2	0.4	0.1	-0.0	0.1
Locomotor activity	1.4	2.3	2.7	-1.5	1.5	1.2	-1.7	1.6
Locomotor testing distance	1.7	2.8	3.8	-1.5	1.8	1.2	-1.9	1.9
Locomotor testing rearing	1.4	2.2	3.3	-1.0	1.7	0.7	-1.8	1.8
Locomotion in novel chamber	3.3	4.1	7.5	-2.7	2.4	2.7	-0.1	-0.0
Locomotion in novel chamber post-restriction	2.2	2.7	4.8	-2.2	2.0	2.1	-0.1	0.1
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	0.2	-0.4	0.0	0.2	-0.2
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.2	0.1	-0.2	-0.2	0.3
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.7	-1.1	0.7	1.3	0.8	-0.7
Bouts of movement, locomotor time 1	2.1	2.3	3.0	1.7	-1.6	-1.7	-1.2	1.2
Total resting periods, locomotor time 1	1.5	1.7	2.2	1.5	-1.5	-1.4	-1.0	1.0
Rest time, locomotor task time 1	0.8	0.8	1.3	-0.9	1.2	0.8	-0.9	0.8
Distance moved, locomotor task time 1	0.4	0.5	1.2	-0.3	-0.2	0.3	1.1	-1.0
Vertical activity count, locomotor time 1	1.0	1.1	2.2	-1.5	1.1	1.5	0.1	-0.0
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	-0.1	-0.0	0.3	0.7	-0.7
Bouts of movement, locomotor time 2	0.6	0.7	1.2	1.1	-1.0	-1.0	-0.2	0.2
Total resting periods, locomotor time 2	0.3	0.4	0.7	0.8	-0.7	-0.8	-0.1	0.0
Rest time, locomotor task time 2	1.6	1.8	3.1	-1.8	1.7	1.7	0.0	-0.0
Distance moved, locomotor task time 2	0.5	0.6	1.1	1.0	-1.0	-0.9	0.3	-0.3
Vertical activity count, locomotor time 2	0.3	0.3	0.8	0.0	-0.0	-0.1	-0.9	0.9
Light reinforcement 1	0.1	0.1	0.4	-0.1	0.7	-0.0	-0.4	0.3
Light reinforcement 2	0.5	0.7	1.2	-1.0	1.0	1.1	0.3	-0.4
Bone: marrow area	1.4	3.1	4.9	-1.3	1.6	1.3	2.2	-2.2
Bone: maximum diameter	0.1	0.2	0.4	0.7	-0.5	-0.5	-0.0	-0.1
Bone: maximum force	1.8	3.1	6.6	2.1	-2.6	-2.0	0.6	-0.4
Bone: maximum moment	1.5	2.7	5.7	2.0	-2.4	-1.8	0.5	-0.4
Mean time between licks in bursts	1.1	1.6	2.4	1.3	-0.6	-1.5	-1.2	1.3
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	0.4	0.3	-0.2	0.3
Cd content in liver	0.8	0.9	1.9	-1.1	1.4	1.2	-0.0	-0.2
Co content in liver	0.8	1.0	1.8	-1.2	1.3	1.0	-0.6	0.5
Cu content in liver	0.2	0.2	0.6	0.1	-0.8	-0.0	0.5	-0.4
Fe content in liver	0.1	0.2	0.2	0.5	-0.4	-0.5	-0.4	0.4
K content in liver	1.0	1.0	2.8	1.0	-1.7	-0.9	0.4	-0.2
Mg content in liver	0.6	0.7	1.7	0.2	-0.5	-0.1	1.3	-1.1
Mn content in liver	2.5	2.8	4.4	2.1	-2.1	-2.0	-0.8	0.9
Na content in liver	0.7	0.7	1.3	1.0	-1.2	-0.9	-0.5	0.5
Rb content in liver	1.9	2.3	2.7	-1.4	1.7	1.4	1.6	-1.6
Se content in liver	0.0	0.1	0.1	0.2	-0.3	-0.0	-0.3	0.3
Sr content in liver	2.5	2.3	4.2	2.0	-1.5	-2.0	-0.8	0.7
Zn content in liver	0.6	0.7	2.3	0.8	-1.5	-0.7	0.2	-0.1
Bone: minimum diameter	2.0	3.7	6.7	-1.4	1.2	1.4	2.6	-2.5
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.3	0.4	0.3	0.5	-0.4
Time in novel zone, hab. session 1	0.6	0.6	1.2	-0.4	0.5	0.3	-1.1	1.1
Total zone transitions, hab. session 1	0.3	0.5	1.4	0.7	-1.2	-0.6	0.1	0.0
Total locomotion distance, hab. session 1	1.0	1.5	2.1	-1.2	0.7	1.2	1.4	-1.4
Locomotion velocity, hab. session 1	0.6	0.8	1.7	-0.6	0.2	0.7	1.3	-1.2
Time in familiar zone, hab. session 2	0.5	0.6	1.4	0.2	0.0	-0.4	-1.1	1.2
Time in novel zone, hab. session 2	0.2	0.2	0.6	0.1	-0.1	-0.0	0.8	-0.8
Total zone transitions, hab. session 2	1.0	1.3	2.2	1.5	-1.2	-1.5	0.6	-0.4
Total locomotion distance, hab. session 2	0.5	0.7	1.8	-0.3	0.2	0.3	1.3	-1.2
Locomotion velocity, hab. session 2	0.8	1.1	2.4	-0.6	0.4	0.6	1.6	-1.4
Novel to familiar place preference ratio	0.7	0.7	1.4	1.2	-1.0	-1.0	0.4	-0.4
Novelty place preference	0.3	0.3	0.6	0.8	-0.5	-0.6	0.4	-0.5
Time in novel zone, NPP test	0.2	0.3	0.5	0.7	-0.4	-0.6	0.3	-0.4
Total zone transitions, NPP test	1.3	1.9	3.2	1.8	-1.8	-1.7	0.2	-0.0
Total locomotion distance, NPP test	0.4	0.5	1.2	-0.4	-0.1	0.4	1.1	-1.0
Locomotion velocity, NPP test	0.4	0.5	1.3	-0.3	-0.3	0.3	1.1	-1.0
Intraocular pressure	0.4	0.5	0.9	-0.5	1.0	0.5	-0.9	0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.0	0.3	-0.1	-0.4	0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.2	0.2	-0.2	-0.5	0.5
Parametrial fat weight	3.8	7.3	8.8	-2.6	2.4	2.6	3.0	-3.0
Pavlov. Cond. lever latency	0.3	0.4	0.6	-0.5	0.4	0.5	-0.8	0.7
Pavlov. Cond. magazine entry latency	0.5	0.7	1.5	0.4	-0.2	-0.3	1.2	-1.2
Pavlov. Cond. change in total contacts	0.6	0.7	1.6	0.1	-0.2	0.0	1.2	-1.3
Pavlov. Cond. index score	0.2	0.2	0.4	0.4	-0.3	-0.4	0.6	-0.6
Pavlov. Cond. latency score	0.2	0.3	0.6	0.3	-0.1	-0.3	0.7	-0.8
Pavlov. Cond. lever contacts	0.1	0.2	0.4	0.0	-0.0	-0.0	0.6	-0.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.6	0.5	0.4	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	-1.0	0.5	1.0	-0.3	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.6	-0.5	-0.5	0.7	-0.7
Pavlov. Cond. response bias	0.1	0.1	0.1	0.3	-0.3	-0.2	0.2	-0.3
Pavlov. Cond. lever latency	0.2	0.3	0.9	-0.7	0.9	0.5	0.1	-0.2
Pavlov. Cond. magazine entry latency	2.3	2.6	5.5	2.0	-2.3	-1.8	-0.4	0.5
Pavlov. Cond. change in total contacts	1.0	1.4	3.3	1.4	-1.8	-1.1	0.3	-0.3
Pavlov. Cond. index score	1.3	1.7	4.1	1.6	-2.0	-1.3	-0.0	0.1
Pavlov. Cond. latency score	1.0	1.3	3.4	1.3	-1.9	-1.1	0.1	-0.1
Pavlov. Cond. lever contacts	0.5	0.7	0.9	0.9	-0.9	-0.7	-0.8	0.8
Pavlov. Cond. magazine entry number	4.3	5.2	9.8	-2.9	3.1	2.7	0.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.9	-1.3	1.4	1.2	0.3	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.1	4.9	1.8	-2.2	-1.5	-0.1	0.2
Pavlov. Cond. response bias	1.3	1.7	3.1	1.6	-1.8	-1.4	-0.8	0.8
Time in closed arm before self-admin	0.1	0.1	0.2	0.4	-0.3	-0.3	0.3	-0.3
Time in closed arm after self-admin	0.1	0.1	0.1	-0.2	-0.2	0.1	-0.2	0.4
Time in open arm before self-admin	0.5	0.5	1.1	-1.1	0.6	0.8	-0.4	0.6
Time in open arm after self-admin	0.2	0.2	0.3	-0.3	0.4	0.2	-0.6	0.5
Bone: periosteal estimation	0.4	0.8	1.8	-0.3	0.1	0.5	1.3	-1.4
Bone: periosteal perimeter	0.1	0.2	0.2	0.5	-0.4	-0.4	0.4	-0.5
Bone: post-yield work	3.8	5.2	13.3	0.3	-0.6	0.0	3.6	-3.5
Progressive ratio test 1 active lever presses	2.0	2.0	3.7	-1.9	1.7	1.9	-0.1	0.2
Progressive ratio test 1 breakpoint	1.7	1.8	3.2	-1.8	1.6	1.7	-0.3	0.2
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.8	-1.3	1.2	1.3	-0.1	0.2
Progressive ratio test 2 active lever presses	3.0	3.2	6.2	-2.4	2.0	2.5	-0.1	0.0
Progressive ratio test 2 breakpoint	3.6	4.1	7.4	-2.7	2.3	2.7	-0.4	0.3
Progressive ratio test 2 inactive lever presses	6.1	7.0	12.2	-3.4	3.3	3.5	0.6	-0.6
Incentive Sensitization - Responses	0.4	0.4	1.0	-0.9	0.5	1.0	0.1	-0.1
Incentive Sensitization - Breakpoint	0.6	0.6	1.5	-1.1	0.6	1.2	0.1	-0.1
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.1	1.4	-1.2	-1.2	-0.5	0.3
Progressive ratio	1.1	1.3	2.1	1.1	-1.5	-1.0	1.1	-1.0
Food seeking constrained by brief footshock	0.3	0.3	0.4	0.5	-0.7	-0.6	-0.5	0.6
Seeking ratio, punishment vs. effort	1.0	1.2	1.8	-1.1	1.3	0.9	-1.1	1.1
Retroperitoneal fat weight	4.6	15.1	21.6	-4.6	4.6	4.5	2.5	-2.6
Reaction time number correct	0.9	1.2	2.1	0.9	-0.6	-1.0	-1.4	1.4
Reaction time mean minus median	2.2	3.0	6.6	2.0	-2.6	-1.8	-0.7	0.7
Reaction time mean minus median AUC	1.5	2.0	4.1	1.5	-2.0	-1.4	-0.9	1.0
Reaction time num false alarms	0.2	0.3	0.7	-0.8	0.5	0.6	-0.1	0.2
Reaction time num false alarms AUC	0.1	0.1	0.3	-0.3	-0.2	0.1	-0.4	0.5
Reaction time trials correct on left	0.9	1.2	2.1	0.9	-0.6	-1.0	-1.4	1.4
Reaction time trials on left	1.0	1.5	2.4	1.0	-0.7	-1.0	-1.5	1.5
Reaction time mean	0.0	0.0	0.2	0.2	-0.4	-0.0	-0.0	-0.0
Reaction time mean AUC	0.0	0.1	0.2	0.1	-0.4	0.1	0.2	-0.2
Median of all reaction times	0.1	0.2	0.3	-0.3	0.1	0.4	0.4	-0.5
Reaction time omissions	1.1	1.5	3.9	1.0	-2.0	-1.0	-0.8	0.9
Reaction time false alarm rate	0.3	0.4	0.8	-0.9	0.3	0.8	0.3	-0.2
Reaction time premature initiation rate	2.9	3.9	5.5	2.2	-1.7	-2.3	-1.8	1.9
Reaction time premature initiations	5.3	7.5	9.0	2.8	-2.3	-3.0	-2.7	2.8
Std. dev. reaction times	0.7	1.1	2.3	1.2	-1.5	-1.0	-0.6	0.6
Reaction time trials completed	1.0	1.5	2.4	1.0	-0.7	-1.0	-1.5	1.5
Reaction time trials AUC	0.7	1.0	1.9	0.8	-0.4	-0.9	-1.4	1.4
Run reversals in cocaine runway, females	0.4	0.4	1.1	-0.1	-0.6	0.1	1.0	-0.8
Run reversals in cocaine runway, males	0.3	0.3	0.5	-0.6	0.3	0.5	-0.7	0.6
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.5	-0.1	0.5	0.5	-0.4
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.5	-0.2	0.5	0.5	-0.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	0.1
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.1	0.4	-0.2	-0.4	0.5
Total sessions with >9 infusions	1.4	1.6	3.3	-1.8	1.2	1.8	0.3	-0.2
Short access day 1 total inactive lever presses	3.3	3.7	6.3	-2.5	2.5	2.4	0.5	-0.5
Short access day 10 total inactive lever presses	2.3	2.6	4.8	-2.2	1.9	2.1	-0.1	0.1
Short access day 1 total infusions	2.8	3.0	5.8	-2.4	1.7	2.3	0.8	-0.6
Short access day 10 total infusions	1.8	2.0	3.9	-1.9	1.1	2.0	0.9	-0.7
Short access total infusions	1.5	1.7	3.2	-1.8	1.2	1.7	0.7	-0.5
Short access day 1 locomotion	2.0	2.1	4.6	-2.1	1.2	2.1	0.2	0.0
Short access day 10 total locomotion	1.8	2.0	3.8	-1.9	1.2	2.0	0.8	-0.7
Short access total locomotion	1.5	1.5	2.9	-1.7	1.0	1.7	0.7	-0.5
One hour access (0.3 mA shock)	6.5	7.6	13.7	-3.7	3.2	3.7	-0.5	0.5
Compulsive drug intake	2.2	2.2	4.0	1.9	-1.7	-2.0	-0.6	0.7
One hour access (shock baseline)	5.9	6.9	13.1	-3.5	3.0	3.6	-0.2	0.1
Social response proportion	1.9	2.1	3.0	1.7	-1.2	-1.7	-1.3	1.3
Social responses	0.8	1.1	1.2	1.1	-0.8	-1.1	-1.1	1.1
Social time	0.6	0.8	1.3	1.1	-0.8	-1.2	-0.7	0.6
Soleus weight	3.6	10.6	15.7	-4.0	3.7	3.9	2.0	-2.1
Bone: stiffness	1.6	2.5	4.3	1.9	-2.1	-1.7	0.8	-0.8
Tibialis anterior weight	7.0	23.9	43.9	5.7	-6.6	-5.5	-2.5	2.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.6	-0.7	-0.5	0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.6	0.7	1.4	0.9	-1.2	-1.0	0.4	-0.2
Time to tail flick, test, before self-admin	0.9	0.9	2.1	-1.5	0.5	1.4	0.4	-0.1
Time to tail flick, test, after self-admin	0.3	0.3	0.5	0.4	-0.3	-0.4	-0.7	0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	0.6	-0.8	-0.6	0.1	0.0
Delta time to tail flick, test, before/after SA	2.4	2.2	3.8	1.9	-1.1	-1.9	-1.2	1.0
Tibia length	0.6	1.6	3.3	1.6	-1.8	-1.4	0.0	-0.2
Ambulatory time before self-admin	0.3	0.3	0.5	0.7	-0.5	-0.6	0.5	-0.6
Ambulatory time after self-admin	0.4	0.4	1.1	-0.0	0.4	0.2	0.9	-1.0
Bone: tissue strength	0.1	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.3
Total heroin consumption	3.4	4.0	6.9	2.6	-2.5	-2.5	0.3	-0.4
Bone: trabecular number	0.3	0.5	0.9	0.9	-1.0	-0.7	0.5	-0.4
Bone: trabecular spacing	0.2	0.2	0.3	-0.6	0.6	0.4	-0.3	0.3
Bone: trabecular thickness	0.4	0.5	0.6	-0.7	0.6	0.8	0.8	-0.7
Bone: trabecular tissue density	2.6	3.7	6.0	-2.4	2.4	2.4	0.8	-0.9
Water consumed over 24 hours	1.7	2.0	2.4	1.4	-1.1	-1.5	-1.5	1.6
Number of responses in last shaping day	0.7	0.8	1.0	-1.0	1.0	0.8	-0.7	0.8