Hub : Genes

Mrgprf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Mrgprf	0.08	0.06	6.6e-09	0.07	0.05	0.05	0.05	3.2e-10	1.9e-08	5.5e-08	1.5e-08
2	Brain	mRNA stability	Mrgprf	0.13	0.07	1.9e-12	0.14	0.14	0.14	0.14	3.7e-13	8.7e-13	6.1e-13	1.3e-12
3	BLA	gene expression	Mrgprf	0.09	0.07	3.1e-03	0.05	0.05	0.02	0.05	1.1e-03	1.6e-03	1.9e-02	7.8e-04
4	Liver	gene expression	Mrgprf	0.03	0.02	3.4e-03	0.02	0.01	0.01	0.01	1.9e-03	3.5e-02	3.2e-02	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.4	2.5	7.3	-0.5	1.5	-0.2	-2.7
Area under the delay curve	0.3	0.5	1.1	0.1	0.8	-0.1	-1.0
BMI with tail	1.2	4.1	10.9	-2.1	0.7	0.7	-3.3
BMI without tail	0.4	2.2	4.6	-2.2	-0.5	0.5	-1.9
Body weight	1.7	7.5	14.0	-3.7	-1.8	2.7	-2.3
Weight adjusted by age	0.3	0.7	1.2	-1.1	-1.0	0.9	-0.0
Bone surface	1.7	3.4	9.8	-1.8	0.6	0.3	-3.1
Bone volume	1.0	2.0	6.1	-0.7	1.1	-0.4	-2.5
Breakpoint value in progressive ratio session	1.2	2.2	4.5	-1.7	-0.9	2.1	-0.9
Number of licking bursts	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.4
Context. condit. distance diff. score	0.5	0.6	1.4	1.2	0.9	-0.6	0.0
Locomotion velocity, session 1	0.0	0.0	0.1	0.3	0.2	0.0	-0.2
Locomotion distance, session 1	0.8	1.0	3.2	-0.2	1.0	0.1	-1.8
Locomotion velocity, session 2	1.2	1.4	2.8	-1.7	-1.1	1.2	-0.6
Locomotion distance, session 2	0.4	0.6	1.6	-0.8	0.2	0.2	-1.3
Locomotion velocity, session 3	0.9	1.1	2.7	0.1	1.2	-0.3	-1.6
Locomotion distance, session 3	0.1	0.1	0.2	0.1	0.4	-0.1	-0.4
Stereotopy head waving bouts, day 3	0.8	1.0	1.6	0.1	1.2	-0.9	-1.2
Stereotopy head waving duration, day 3	0.9	1.1	1.9	0.8	1.4	-1.2	-0.6
Locomotion velocity, session 7	0.5	0.6	1.2	-0.1	0.7	0.8	-1.1
Locomotion distance, session 7	0.2	0.2	0.5	-0.3	-0.0	0.7	-0.6
Stereotopy head waving bouts, day 7	0.8	0.9	1.8	0.1	1.2	-0.8	-1.3
Stereotopy head waving duration, day 7	0.9	1.1	2.9	-0.9	0.6	0.5	-1.7
Locomotion velocity, session 8	0.8	1.0	1.5	-1.2	-0.7	1.2	-0.7
Locomotion distance, session 8	0.5	0.7	1.2	0.9	1.1	-0.6	-0.5
Degree of sensitization distance	0.3	0.4	0.6	-0.4	0.1	0.8	-0.7
Degree of sensitization stereotypy	0.4	0.4	1.2	-0.5	0.4	-0.0	-1.1
Conditioned locomotion	2.3	2.7	4.2	-1.4	-2.1	1.9	1.0
Cocaine response after cond. corrected	0.0	0.1	0.1	0.3	0.4	-0.1	-0.1
Cocaine response after cond. not corrected	0.2	0.2	0.4	0.2	0.7	-0.4	-0.5
Cocaine response before conditioning	0.2	0.2	0.4	-0.3	0.1	-0.6	-0.5
Saline control response	2.2	3.0	4.9	-2.2	-1.5	2.0	-1.0
Bone: connectivity density	2.1	3.4	9.8	-1.7	0.8	0.5	-3.1
Bone: cortical apparent density	0.4	0.6	1.0	-0.7	-1.0	0.9	0.5
Bone: cortical area	0.3	0.5	1.1	-0.9	-1.1	-0.0	0.5
Bone: cortical porosity	0.1	0.1	0.3	-0.1	0.2	0.6	-0.2
Bone: cortical porosity	0.2	0.3	0.6	-0.5	-0.2	0.8	-0.2
Bone: cortical thickness	2.9	4.9	9.2	-2.7	-3.0	1.5	1.0
Bone: cortical thickness	1.0	1.2	2.0	-1.4	-1.4	1.0	0.1
Bone: cortical tissue density	0.6	0.9	1.4	-0.9	-1.2	1.1	0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.7	-0.3	0.4	0.2	-0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.1	0.4	-0.4	-0.5
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.1	0.2	-0.3
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	-0.1	0.2	0.4
Incentive salience index mean	0.2	0.3	0.5	-0.3	0.3	0.6	-0.7
Condit. Reinf. lever presses	0.1	0.1	0.6	-0.1	-0.1	0.8	0.1
Condit. Reinf. active minus inactive responses	0.8	1.3	2.7	0.8	1.7	-0.8	-1.1
Condit. Reinf. active-inactive response ratio	1.5	2.4	4.0	1.7	2.0	-1.6	-0.3
Condit. Reinf. active responses	0.8	1.1	2.6	-0.0	1.3	0.3	-1.6
Condit. Reinf. inactive responses	1.1	1.7	2.3	-1.5	-0.2	1.5	-1.5
Condit. Reinf. lever presses	0.6	0.9	2.7	-0.8	0.5	-0.1	-1.6
Condit. Reinf. lever reinforcers received	0.9	1.2	3.1	-0.3	1.1	0.6	-1.8
Conditioned reinforcement - actives	0.1	0.5	1.5	0.4	-0.7	0.2	1.2
Conditioned reinforcement - inactives	0.7	1.8	3.6	1.9	1.5	-1.1	0.5
Conditioned locomotion	4.9	7.3	12.8	3.6	1.9	-2.9	2.1
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.5	0.2	0.4	-0.1
Patch foraging indifference point AUC	0.6	1.4	2.4	-1.2	-1.5	1.3	0.5
Delay disc. indifference point, 0s delay	1.0	1.1	2.4	0.1	1.4	-0.0	-1.5
Delay disc. indifference point, 16s delay	0.8	1.1	1.8	1.2	1.1	-1.3	0.1
Delay disc. indifference point, 2s delay	0.4	0.5	1.2	0.6	1.1	-0.3	-0.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.7	-0.4	-0.8	-0.1	0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	0.1	0.7	0.5	-0.7
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	-0.3	0.2	0.1	-0.7
Indifference point function ln k	1.2	3.7	7.3	2.7	1.7	-1.9	1.0
Indifference point function log k	1.2	3.7	7.3	2.7	1.7	-1.9	1.0
Patch foraging total patch changes 0 sec	0.1	0.3	0.8	0.1	-0.5	0.9	0.3
Patch foraging total patch changes 12 sec	2.1	2.8	4.1	-2.0	-1.6	2.0	-0.6
Patch foraging total patch changes 18 sec	0.4	0.8	2.0	-0.8	-0.6	1.4	-0.5
Patch foraging total patch changes 24 sec	0.4	1.5	2.3	-1.2	-1.5	1.5	0.3
Patch foraging total patch changes 6 sec	0.9	1.5	2.0	-1.4	-0.6	1.4	-1.3
Patch foraging time to switch 0 sec	0.6	2.3	6.3	-1.5	0.7	0.3	-2.5
Patch foraging water rate 0 sec	1.3	4.8	10.2	2.6	-0.2	-1.5	3.2
Patch foraging water rate 12 sec	2.1	8.5	11.9	3.3	0.7	-3.3	3.5
Patch foraging water rate 18 sec	0.7	1.7	3.2	1.8	0.9	-1.0	1.3
Patch foraging water rate 24 sec	2.3	3.2	7.4	1.9	-0.1	-1.4	2.7
Patch foraging water rate 6 sec	1.6	2.4	6.0	1.4	-0.6	-1.2	2.5
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.3	-0.2	0.7	0.3	-1.1
Distance traveled before self-admin	0.1	0.2	0.6	-0.2	0.4	-0.0	-0.8
Distance traveled after self-admin	0.0	0.1	0.1	-0.0	0.1	-0.3	-0.3
Extensor digitorum longus weight	4.5	18.1	31.0	-5.6	-4.4	4.6	-1.0
Bone: elastic displacement	1.2	1.6	4.2	0.2	-1.4	0.2	2.1
Bone: elastic work	1.2	1.6	3.6	-1.4	-1.9	0.6	0.7
Bone: endosteal estimation	1.4	3.3	5.3	1.9	2.3	-1.9	-0.9
Bone: endosteal perimeter	2.1	5.2	10.0	2.5	3.2	-1.8	-1.2
Epididymis fat weight	1.9	9.6	16.1	4.0	2.6	-3.6	1.7
Delta time in closed arm before/after self-admin	0.9	0.8	1.5	-1.1	-1.2	0.6	0.1
Delta time in open arm before/after self-admin	0.4	0.5	1.0	0.4	1.0	-0.5	-0.6
Diff in mean of infusions in LGA sessions	0.6	1.1	2.0	-1.2	-0.9	1.4	-0.1
Delay discount exponential model param	0.2	0.3	0.8	-0.0	-0.7	-0.0	0.9
Extinction: sum of active levers before priming	0.8	1.2	2.1	-1.5	-0.3	0.9	-1.4
Active lever presses in extinction session 6	1.1	1.1	2.5	-1.0	-1.0	1.6	-0.0
Bone: final force	0.6	1.0	1.9	-1.4	-0.5	0.9	-1.0
Bone: final moment	0.5	0.9	1.8	-1.3	-0.5	0.8	-0.9
Food consumed during 24 hour testing period	0.3	0.7	1.8	0.7	0.1	-1.3	0.7
Glucose	2.2	3.4	7.9	1.7	2.8	-1.2	-1.3
Heart weight	0.7	1.1	2.3	0.3	1.5	0.2	-1.4
Delay discount hyperbolic model param	0.3	0.4	0.8	-0.1	-0.8	-0.0	0.9
Intermittent access intake day 1-15 change	0.4	2.4	4.7	2.2	1.2	-1.4	1.2
Intermittent access intake escalation	0.4	2.1	4.0	2.0	1.0	-1.3	1.2
Intermittent access intake escalation 2	0.9	1.5	3.1	1.7	1.1	-1.0	0.9
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.0	-0.1	0.1
Intermitt. access day 15 inactive lever presses	0.3	1.7	2.8	1.2	1.7	-1.6	-0.3
Intermitt. access escalation Index	0.7	2.2	3.3	1.8	0.6	-1.8	1.5
Intermittent access day 1 total infusions	0.9	2.7	6.6	1.3	2.6	-0.7	-1.4
Intermittent access day 15 total infusions	1.9	4.7	7.6	2.8	2.6	-2.1	0.4
Intermittent access terminal intake (last 3 days)	2.1	3.6	7.0	2.3	2.7	-1.5	-0.2
Intermittent access total infusions	1.8	2.2	4.9	1.7	2.2	-0.9	-0.5
Intermittent access day 1 locomotion	0.7	1.2	2.8	1.0	1.7	-0.7	-0.9
Intermittent access day 15 total locomotion	1.3	4.9	7.7	2.8	2.7	-2.1	0.2
Intermittent access total locomotion	5.1	6.2	10.5	3.1	3.2	-2.2	-0.1
Intermittent access standard deviation	0.2	0.8	1.1	1.1	1.0	-1.0	0.1
Left kidney weight	0.4	3.5	5.6	2.3	1.7	-2.4	0.6
Right kidney weight	0.3	2.3	3.7	1.9	1.0	-1.7	1.2
Cocaine induced anxiety	0.0	0.1	0.2	0.2	0.5	-0.3	-0.4
Post-drug Anxiety	0.2	0.2	0.4	-0.6	-0.2	0.4	-0.6
Baseline Anxiety	0.3	0.5	0.8	-0.8	-0.9	0.8	-0.0
Tail length	0.6	3.4	6.5	-1.8	-2.5	1.8	0.7
Length with tail	1.9	8.3	11.2	-3.4	-3.3	3.3	-0.1
Length without tail	1.1	5.6	8.6	-2.7	-2.5	2.9	-0.3
Times rat made contact with spout	0.4	0.5	1.3	-0.6	0.2	0.3	-1.2
Lifetime Intake	0.9	1.1	2.6	1.1	1.6	-0.5	-0.4
Liver weight, left	0.3	0.5	1.5	0.6	-0.3	-0.4	1.2
Liver weight, right	0.6	1.1	1.8	1.4	0.4	-0.7	1.3
Locomotor activity	0.9	1.3	2.4	1.6	0.6	-1.2	1.0
Locomotor testing distance	0.8	1.9	3.1	1.6	0.4	-1.7	1.3
Locomotor testing rearing	0.5	1.7	2.6	1.5	1.4	-1.6	0.0
Locomotion in novel chamber	3.7	5.0	9.0	3.0	2.6	-2.0	0.6
Locomotion in novel chamber post-restriction	1.1	3.3	6.3	2.5	1.9	-1.6	0.7
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	0.4	0.2	-0.3	0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	-0.1	0.5	-0.4
Time >=10cm from walls, locomotor time 1	1.9	2.4	4.6	1.3	2.1	-1.4	-1.1
Bouts of movement, locomotor time 1	0.8	1.1	1.9	-0.7	-1.4	1.3	0.4
Total resting periods, locomotor time 1	0.5	0.6	1.1	-0.2	-1.0	0.9	0.6
Rest time, locomotor task time 1	1.1	1.8	2.8	1.5	0.3	-1.5	1.7
Distance moved, locomotor task time 1	0.3	0.8	2.1	-0.2	0.9	0.5	-1.5
Vertical activity count, locomotor time 1	0.1	1.0	1.6	1.0	1.3	-1.0	-0.6
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.3	0.5	-0.1	-0.4	0.6
Bouts of movement, locomotor time 2	0.1	0.4	0.6	-0.8	-0.7	0.6	-0.3
Total resting periods, locomotor time 2	0.0	0.1	0.2	-0.4	-0.3	0.3	-0.4
Rest time, locomotor task time 2	1.3	2.1	3.3	1.7	1.8	-1.6	-0.0
Distance moved, locomotor task time 2	0.9	1.2	2.1	-1.0	-1.5	1.2	0.4
Vertical activity count, locomotor time 2	0.5	1.3	2.8	-0.2	-1.7	0.1	1.5
Light reinforcement 1	0.1	0.5	1.0	0.8	0.0	-0.6	1.0
Light reinforcement 2	0.8	1.8	3.5	1.9	0.9	-1.1	1.3
Bone: marrow area	1.4	3.4	5.4	1.9	2.3	-1.9	-0.9
Bone: maximum diameter	0.1	0.3	0.8	0.5	0.2	-0.9	0.4
Bone: maximum force	0.9	1.8	5.2	-1.3	0.5	-0.1	-2.3
Bone: maximum moment	0.8	1.6	4.5	-1.2	0.4	-0.2	-2.1
Mean time between licks in bursts	0.2	0.9	1.5	-1.1	-0.9	1.2	-0.2
Mean num. licks in bursts	0.0	0.1	0.1	-0.1	0.2	0.2	-0.4
Cd content in liver	1.4	1.6	2.7	1.6	1.2	-1.4	0.5
Co content in liver	1.1	1.3	3.7	0.6	-0.9	-0.4	1.9
Cu content in liver	0.0	0.1	0.1	0.1	-0.0	-0.3	0.3
Fe content in liver	0.2	0.3	1.1	-0.1	-0.2	1.1	0.1
K content in liver	0.3	0.3	0.7	-0.6	0.2	-0.1	-0.8
Mg content in liver	0.7	0.8	2.1	0.5	0.8	-1.5	-0.3
Mn content in liver	1.7	1.9	3.1	-1.8	-1.2	1.6	-0.7
Na content in liver	0.5	0.6	0.9	-0.1	-0.7	-0.9	0.9
Rb content in liver	0.9	1.1	2.5	1.2	1.6	-0.4	-0.6
Se content in liver	0.3	0.3	0.7	0.5	0.8	0.1	-0.5
Sr content in liver	1.4	1.2	2.6	-1.4	-1.6	0.4	0.3
Zn content in liver	0.4	0.5	1.0	-0.8	-1.0	0.1	0.5
Bone: minimum diameter	1.6	3.1	6.1	1.5	2.5	-1.5	-1.4
Time in familiar zone, hab. session 1	0.8	0.9	2.0	0.8	0.9	-1.4	-0.2
Time in novel zone, hab. session 1	0.1	0.2	0.4	-0.3	-0.4	0.6	0.1
Total zone transitions, hab. session 1	0.3	0.4	1.0	-0.6	0.0	-1.0	-0.6
Total locomotion distance, hab. session 1	1.1	1.5	4.3	0.9	1.0	-2.1	0.1
Locomotion velocity, hab. session 1	0.5	0.7	2.0	0.5	0.6	-1.4	0.1
Time in familiar zone, hab. session 2	0.6	0.7	1.3	-0.5	-1.0	1.1	0.5
Time in novel zone, hab. session 2	0.6	0.6	1.2	0.1	0.9	-0.7	-1.1
Total zone transitions, hab. session 2	1.9	2.5	7.9	-0.8	1.2	0.2	-2.8
Total locomotion distance, hab. session 2	0.8	1.0	2.1	0.2	1.4	-0.3	-1.5
Locomotion velocity, hab. session 2	0.9	1.2	2.3	0.5	1.5	-0.7	-1.3
Novel to familiar place preference ratio	0.2	0.3	0.8	-0.5	0.1	0.3	-0.9
Novelty place preference	0.2	0.2	0.7	-0.3	0.3	0.1	-0.8
Time in novel zone, NPP test	0.2	0.2	0.7	-0.3	0.3	0.2	-0.8
Total zone transitions, NPP test	0.6	0.9	2.9	-0.6	0.5	0.2	-1.7
Total locomotion distance, NPP test	0.3	0.5	1.0	0.5	1.0	-0.2	-0.8
Locomotion velocity, NPP test	0.3	0.4	0.7	0.5	0.9	-0.5	-0.6
Intraocular pressure	0.5	0.9	2.6	0.8	-0.4	-0.5	1.6
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.2	-0.2	-0.2	0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.1	-0.5	0.2	0.4
Parametrial fat weight	2.2	5.1	7.9	2.8	2.7	-2.3	0.2
Pavlov. Cond. lever latency	0.3	0.4	0.7	0.7	0.2	-0.9	0.5
Pavlov. Cond. magazine entry latency	0.5	0.6	1.2	0.2	1.0	0.3	-1.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	0.6	0.9	-0.2	-0.5
Pavlov. Cond. index score	0.0	0.0	0.1	0.2	0.3	0.1	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	0.0	0.3	0.5	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.3	0.1	0.5	-0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	-0.2	-0.2	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	0.2	-0.6	-0.9	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.1	0.3	0.1	-0.2
Pavlov. Cond. response bias	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.0	0.0	0.6	0.0
Pavlov. Cond. magazine entry latency	1.8	2.6	4.7	-1.7	-0.1	1.6	-2.2
Pavlov. Cond. change in total contacts	0.2	0.5	1.6	-0.2	0.7	-0.1	-1.3
Pavlov. Cond. index score	0.4	0.7	1.7	-0.8	0.2	0.5	-1.3
Pavlov. Cond. latency score	0.3	0.4	1.2	-0.7	0.1	0.3	-1.1
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.1	0.1	-0.6	-0.2
Pavlov. Cond. magazine entry number	2.3	2.9	5.3	2.0	0.2	-1.6	2.3
Pavlov. Cond. intertrial magazine entries	0.3	0.7	1.2	0.9	0.2	-1.0	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	2.0	-1.0	0.0	0.6	-1.4
Pavlov. Cond. response bias	0.5	0.6	1.8	-0.8	0.3	0.4	-1.3
Time in closed arm before self-admin	0.6	1.0	2.1	1.0	1.4	-0.7	-0.5
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	0.0	0.1	0.3
Time in open arm before self-admin	0.9	1.1	2.7	-1.1	-1.6	0.5	0.5
Time in open arm after self-admin	0.3	0.3	0.6	-0.7	-0.4	0.3	-0.6
Bone: periosteal estimation	0.2	0.5	1.2	0.6	0.7	-1.1	-0.2
Bone: periosteal perimeter	0.3	0.5	1.1	0.4	1.0	-0.3	-0.8
Bone: post-yield work	3.8	6.5	13.0	0.6	3.2	-1.5	-3.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.0	-0.3	0.5	0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.0	-0.3	0.5	0.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1
Progressive ratio test 2 active lever presses	0.7	1.0	1.8	1.3	1.2	-0.9	0.3
Progressive ratio test 2 breakpoint	0.7	0.9	1.6	1.3	1.1	-0.8	0.3
Progressive ratio test 2 inactive lever presses	1.8	5.6	8.7	2.9	2.6	-2.5	0.7
Incentive Sensitization - Responses	0.1	0.4	0.8	-0.0	0.8	0.0	-0.9
Incentive Sensitization - Breakpoint	0.2	0.4	0.8	0.2	0.9	-0.1	-0.8
Sum of active levers in priming session hrs 5-6	1.9	1.8	4.4	0.0	-1.7	-0.3	2.1
Progressive ratio	1.1	3.2	8.3	-0.9	1.3	1.5	-2.9
Food seeking constrained by brief footshock	0.2	0.2	0.3	-0.6	-0.2	0.6	-0.5
Seeking ratio, punishment vs. effort	0.9	2.1	4.8	0.8	-0.9	-1.5	2.2
Retroperitoneal fat weight	4.7	21.1	35.4	5.9	4.3	-5.1	2.1
Reaction time number correct	0.1	0.5	0.7	-0.5	-0.9	0.9	0.5
Reaction time mean minus median	0.1	0.9	2.3	-1.5	-0.4	0.4	-1.1
Reaction time mean minus median AUC	0.1	0.6	1.7	-1.3	-0.7	0.2	-0.5
Reaction time num false alarms	0.3	0.6	1.3	-0.0	-1.0	0.1	1.1
Reaction time num false alarms AUC	0.4	1.0	1.8	-0.7	-1.3	1.1	0.7
Reaction time trials correct on left	0.1	0.5	0.7	-0.5	-0.9	0.9	0.5
Reaction time trials on left	0.2	0.6	1.0	-0.6	-1.0	1.0	0.6
Reaction time mean	0.2	0.4	0.9	0.0	0.7	-0.9	-0.6
Reaction time mean AUC	0.2	0.5	0.9	0.2	0.8	-1.0	-0.7
Median of all reaction times	0.5	0.7	1.1	0.4	1.0	-1.1	-0.7
Reaction time omissions	1.0	1.7	2.8	-1.7	-0.9	1.6	-0.8
Reaction time false alarm rate	0.2	0.3	0.7	-0.2	-0.9	0.4	0.6
Reaction time premature initiation rate	1.3	2.1	4.0	-2.0	-1.5	1.1	-0.9
Reaction time premature initiations	1.1	3.2	5.6	-2.4	-2.2	1.5	-0.4
Std. dev. reaction times	0.1	0.3	0.6	-0.7	0.0	-0.1	-0.8
Reaction time trials completed	0.2	0.6	1.0	-0.6	-1.0	1.0	0.6
Reaction time trials AUC	0.1	0.5	0.8	-0.5	-0.9	0.9	0.5
Run reversals in cocaine runway, females	0.6	0.7	1.7	-0.6	0.6	0.7	-1.3
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.0	-0.8	-0.0	0.9
Latency to leave start box in cocaine runway	0.6	0.8	1.6	0.4	1.3	-0.6	-1.1
Latency to leave start box in cocaine runway, F	0.6	0.8	1.6	0.3	1.3	-0.5	-1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.2
Std. dev. time between licks in bursts	0.9	1.7	2.9	-0.8	-1.5	1.7	1.0
Total sessions with >9 infusions	0.4	0.5	1.4	-0.5	-0.1	1.2	-0.5
Short access day 1 total inactive lever presses	0.7	1.5	2.4	1.5	1.1	-1.4	0.5
Short access day 10 total inactive lever presses	0.1	0.3	1.3	0.0	0.2	-1.2	-0.1
Short access day 1 total infusions	0.2	0.5	0.8	0.8	0.9	-0.6	0.0
Short access day 10 total infusions	0.8	1.3	2.0	0.0	1.4	1.2	-1.4
Short access total infusions	0.3	0.4	0.6	-0.2	0.6	0.7	-0.8
Short access day 1 locomotion	0.4	0.6	1.0	1.0	1.0	-0.7	-0.0
Short access day 10 total locomotion	0.2	0.6	1.5	0.8	1.2	-0.2	-0.6
Short access total locomotion	0.4	0.6	1.4	0.9	1.2	-0.3	-0.3
One hour access (0.3 mA shock)	2.7	3.2	4.7	2.2	1.9	-2.0	0.5
Compulsive drug intake	1.9	2.7	5.2	-1.9	-2.3	1.5	0.2
One hour access (shock baseline)	2.0	5.1	8.4	2.9	2.5	-2.3	0.8
Social response proportion	0.4	0.5	1.0	-0.5	0.4	0.8	-1.0
Social responses	0.2	0.3	0.5	-0.5	-0.7	0.7	0.1
Social time	0.2	0.3	0.7	-0.8	-0.5	0.6	-0.3
Soleus weight	2.5	7.5	14.2	3.8	1.4	-2.6	2.6
Bone: stiffness	0.8	1.5	4.7	-0.8	0.9	-0.0	-2.2
Tibialis anterior weight	5.4	18.4	32.6	-5.6	-5.7	3.1	0.6
Time to tail flick, vehicle, before self-admin	1.0	1.2	2.4	-0.4	0.9	1.2	-1.6
Time to tail flick, vehicle, after self-admin	0.8	1.7	3.4	-1.5	0.2	1.0	-1.9
Time to tail flick, test, before self-admin	1.3	1.4	3.4	0.8	1.8	-0.4	-1.3
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.4	-0.5	0.2	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.5	1.2	-1.1	-0.4	0.1	-0.7
Delta time to tail flick, test, before/after SA	2.6	3.2	7.4	-1.2	-2.7	0.7	1.9
Tibia length	0.4	1.0	1.9	-0.4	-1.3	0.5	1.4
Ambulatory time before self-admin	0.1	0.4	1.0	0.0	0.8	0.1	-1.0
Ambulatory time after self-admin	0.7	1.1	2.1	1.0	1.5	-0.8	-0.7
Bone: tissue strength	1.1	1.2	3.9	0.4	0.8	-2.0	-0.4
Total heroin consumption	3.6	4.3	7.0	-2.6	-1.9	2.4	-0.8
Bone: trabecular number	1.2	2.2	6.9	-0.8	1.2	0.2	-2.6
Bone: trabecular spacing	0.4	0.6	1.9	0.4	-0.7	0.2	1.4
Bone: trabecular thickness	1.3	1.7	3.0	0.7	1.7	-1.2	-1.4
Bone: trabecular tissue density	3.2	5.6	9.8	3.1	1.0	-2.2	2.6
Water consumed over 24 hours	0.3	0.7	1.2	-1.1	-0.3	0.5	-1.1
Number of responses in last shaping day	0.1	0.1	0.3	-0.3	-0.5	-0.2	0.2