Hub : Genes

Extl3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Extl3 0.07 0.04 3.9e-08 0.1 0.1 0.1 0.09 1.3e-08 1.1e-08 1.9e-08 5.1e-08
2 Brain gene expression Extl3 0.15 0.09 1.5e-11 0.05 0.11 0.08 0.09 1.5e-05 1.2e-10 4.8e-08 5.0e-09
3 NAcc gene expression Extl3 0.06 0.03 3.6e-13 0.09 0.07 0.08 0.03 2.1e-13 3.1e-11 9.6e-13 3.7e-05
4 NAcc isoform ratio XM_039093622.2 0.01 0.01 9.2e-03 0 0 -0 0 1.4e-01 1.4e-01 7.9e-01 3.3e-01
5 Brain mRNA stability Extl3 0.04 0.03 2.3e-03 0.01 0.01 0.01 0 5.5e-02 2.1e-02 1.7e-02 9.3e-02
6 Liver gene expression Extl3 0.06 0.03 2.7e-08 0.07 0.06 0.04 0.05 4.8e-08 3.5e-07 1.0e-05 3.2e-06
7 NAcc mRNA stability Extl3 0.04 0.02 3.5e-05 0.03 0.03 0.02 0.03 2.8e-05 3.9e-05 2.9e-04 3.6e-05
8 Adipose isoform ratio NM_020097.2 0.06 0.03 3.1e-05 0.03 0.03 0.03 0.03 1.4e-04 2.6e-04 3.5e-04 4.3e-04
9 Adipose alternative polyA XM_039093619.2 0.03 0.02 2.4e-03 0 0.01 0.01 0.01 9.9e-02 1.7e-02 5.1e-02 5.3e-02
10 Adipose alternative polyA NM_020097.2 0.03 0.02 2.7e-03 0 0.01 0.01 0.01 9.5e-02 1.8e-02 6.7e-02 6.8e-02
11 PL mRNA stability Extl3 0.04 0.03 3.9e-04 0.03 0.03 0.03 0.02 8.3e-04 3.3e-04 8.8e-04 1.1e-03
12 Adipose isoform ratio XM_039093622.2 0.06 0.04 3.9e-05 0.03 0.04 0.03 0.04 1.5e-04 5.0e-05 9.3e-05 7.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.40.71.6-1.1-0.41.21.0-1.3-0.8-0.21.20.1-0.10.20.7
Area under the delay curve1.52.35.52.32.1-2.4-1.52.02.20.20.30.3-0.40.60.2
BMI with tail0.20.82.80.81.0-1.4-0.91.71.20.70.1-0.10.1-0.1-0.6
BMI without tail0.00.20.7-0.8-0.40.10.40.7-0.10.10.90.5-0.50.3-0.1
Body weight0.93.85.92.02.4-2.3-2.22.12.22.2-1.0-1.61.5-1.5-1.8
Weight adjusted by age1.54.37.52.01.8-1.4-2.21.20.72.3-2.7-2.42.4-2.5-2.3
Bone surface0.20.41.9-0.6-0.21.00.7-1.4-0.4-0.10.6-0.10.1-0.00.6
Bone volume0.30.51.7-0.5-0.10.70.8-1.3-0.4-0.41.10.4-0.30.41.0
Breakpoint value in progressive ratio session0.30.52.20.80.9-1.1-0.50.61.50.10.60.4-0.40.50.3
Number of licking bursts0.10.20.70.10.3-0.7-0.30.80.5-0.10.80.4-0.40.50.1
Context. condit. distance diff. score3.94.76.5-2.3-2.41.22.2-0.4-2.0-2.42.42.5-2.62.62.0
Locomotion velocity, session 10.10.20.40.40.6-0.4-0.1-0.30.60.10.60.1-0.10.20.4
Locomotion distance, session 10.20.21.30.60.6-0.1-0.0-1.1-0.10.00.1-0.20.3-0.10.5
Locomotion velocity, session 20.20.20.50.70.6-0.4-0.1-0.60.4-0.20.40.2-0.10.30.7
Locomotion distance, session 20.30.42.70.50.70.30.1-1.6-0.40.10.2-0.40.4-0.30.6
Locomotion velocity, session 31.01.23.40.71.0-1.0-1.01.81.21.3-0.6-0.70.6-0.9-1.3
Locomotion distance, session 30.20.20.90.30.6-0.8-0.50.90.40.40.20.1-0.10.1-0.4
Stereotopy head waving bouts, day 30.91.13.00.20.00.4-0.60.40.40.9-1.7-1.41.4-1.5-1.3
Stereotopy head waving duration, day 31.31.63.11.00.9-0.6-1.21.11.01.4-1.7-1.31.3-1.5-1.6
Locomotion velocity, session 73.74.06.4-2.4-2.31.21.9-0.3-1.4-2.22.52.2-2.22.41.8
Locomotion distance, session 74.76.111.0-2.8-2.31.82.6-1.5-2.3-2.43.32.5-2.52.62.4
Stereotopy head waving bouts, day 71.92.32.71.61.5-1.2-1.71.41.31.6-1.6-1.51.4-1.5-1.6
Stereotopy head waving duration, day 73.74.56.32.01.8-1.7-2.32.31.82.2-2.5-2.02.0-2.2-2.5
Locomotion velocity, session 80.40.41.0-0.2-0.2-0.20.40.30.2-0.70.91.0-1.01.00.7
Locomotion distance, session 81.31.93.7-1.1-0.90.81.4-0.9-1.2-1.41.91.5-1.51.61.7
Degree of sensitization distance7.68.110.2-3.2-3.12.63.2-2.5-2.7-3.13.02.6-2.52.72.9
Degree of sensitization stereotypy1.01.11.91.41.2-1.3-1.21.21.01.0-0.9-0.60.6-0.7-0.9
Conditioned locomotion0.91.11.6-1.2-1.30.91.1-0.6-1.1-1.20.91.0-1.01.00.9
Cocaine response after cond. corrected1.11.63.3-1.0-0.90.21.10.4-0.3-1.31.81.8-1.81.71.2
Cocaine response after cond. not corrected0.91.44.3-0.8-0.5-0.00.90.40.0-1.02.11.6-1.61.61.2
Cocaine response before conditioning0.60.71.60.81.3-0.5-0.8-0.20.81.1-0.1-1.11.1-0.9-0.5
Saline control response0.50.61.30.70.7-0.2-0.7-0.40.40.7-1.1-1.11.1-1.0-0.6
Bone: connectivity density0.71.23.8-1.7-0.92.00.9-1.4-1.30.20.6-0.70.8-0.6-0.1
Bone: cortical apparent density0.20.32.20.10.2-0.7-0.31.50.70.10.40.3-0.30.3-0.3
Bone: cortical area0.30.51.61.10.9-1.3-0.4-0.00.4-0.30.40.5-0.60.70.6
Bone: cortical porosity1.01.12.71.61.4-1.5-1.40.70.90.8-0.9-0.70.7-0.6-0.7
Bone: cortical porosity1.21.43.11.71.5-1.4-1.50.50.61.0-1.3-1.01.0-0.9-0.9
Bone: cortical thickness0.50.93.51.41.2-1.9-0.90.80.9-0.10.30.5-0.60.70.3
Bone: cortical thickness2.12.56.40.30.0-1.40.50.50.5-1.82.02.3-2.32.51.9
Bone: cortical tissue density0.20.32.1-0.00.1-0.6-0.21.50.70.10.50.3-0.40.3-0.3
Condit. Reinf. active minus inactive responses0.50.61.10.90.7-0.6-0.90.20.60.7-1.0-0.90.9-0.8-0.7
Condit. Reinf. active-inactive response ratio0.10.10.5-0.0-0.20.1-0.20.2-0.10.3-0.7-0.40.4-0.5-0.5
Condit. Reinf. active responses0.50.61.21.11.0-0.8-1.0-0.00.80.6-0.8-0.90.9-0.7-0.4
Condit. Reinf. inactive responses0.40.51.10.91.1-0.6-0.8-0.40.70.5-0.3-0.90.9-0.5-0.0
Incentive salience index mean1.52.03.51.91.6-1.5-1.70.71.51.2-1.4-1.31.3-1.1-1.0
Condit. Reinf. lever presses1.52.34.72.22.1-1.9-1.90.82.01.2-1.0-1.21.2-0.9-0.8
Condit. Reinf. active minus inactive responses0.30.41.1-0.3-0.60.50.6-1.0-0.4-0.90.30.5-0.40.60.8
Condit. Reinf. active-inactive response ratio0.10.10.3-0.4-0.60.30.40.10.0-0.50.10.4-0.40.30.3
Condit. Reinf. active responses0.40.61.5-0.5-0.60.70.8-1.2-0.5-0.90.70.6-0.60.71.1
Condit. Reinf. inactive responses0.81.23.3-0.9-0.81.11.2-1.8-1.1-1.01.10.7-0.60.81.4
Condit. Reinf. lever presses0.30.51.10.40.50.2-0.4-0.4-0.00.8-0.9-1.01.0-1.1-0.6
Condit. Reinf. lever reinforcers received0.20.30.8-0.2-0.30.40.5-0.9-0.3-0.60.40.4-0.40.40.7
Conditioned reinforcement - actives1.14.57.0-2.6-2.42.62.6-2.3-2.5-1.82.01.5-1.41.21.6
Conditioned reinforcement - inactives0.30.82.3-1.5-1.01.50.8-1.0-1.0-0.21.2-0.40.4-0.10.1
Conditioned locomotion1.82.74.1-1.4-1.51.11.7-0.8-1.0-1.92.02.0-2.01.91.8
Patch foraging indifference point 0 sec0.41.22.81.11.3-0.0-0.9-1.2-0.20.9-0.9-1.61.7-1.3-0.4
Patch foraging indifference point AUC0.71.54.1-0.8-1.00.21.30.5-0.4-1.21.12.0-2.01.61.1
Delay disc. indifference point, 0s delay0.10.10.40.50.60.2-0.2-0.60.3-0.4-0.0-0.30.3-0.00.6
Delay disc. indifference point, 16s delay0.91.32.61.31.2-1.6-0.71.31.5-0.31.10.9-0.91.10.7
Delay disc. indifference point, 2s delay0.30.41.61.31.2-0.7-0.60.20.60.1-0.2-0.20.3-0.10.3
Delay disc. indifference point, 24s delay1.11.82.81.21.1-1.7-0.41.41.6-0.81.71.4-1.41.61.2
Delay disc. indifference point, 4s delay2.22.34.92.11.9-2.1-1.72.22.20.9-0.9-0.40.3-0.3-0.7
Delay disc. indifference point, 8s delay1.42.35.92.21.9-2.4-1.72.32.20.5-0.10.1-0.10.2-0.3
Indifference point function ln k0.51.42.81.21.3-0.7-1.4-0.30.41.2-1.2-1.61.7-1.4-1.0
Indifference point function log k0.51.42.81.21.3-0.7-1.4-0.30.41.2-1.2-1.61.7-1.4-1.0
Patch foraging total patch changes 0 sec0.51.53.01.51.6-0.5-1.2-0.90.21.1-1.2-1.71.7-1.4-0.6
Patch foraging total patch changes 12 sec0.10.10.50.60.7-0.6-0.2-0.00.50.10.20.0-0.00.10.3
Patch foraging total patch changes 18 sec0.20.51.0-0.4-0.50.30.8-0.6-0.4-0.80.70.8-0.80.81.0
Patch foraging total patch changes 24 sec0.10.20.60.80.8-0.2-0.3-0.40.30.4-0.3-0.30.3-0.30.1
Patch foraging total patch changes 6 sec0.00.00.10.20.4-0.0-0.20.20.20.10.2-0.10.1-0.1-0.0
Patch foraging time to switch 0 sec0.00.20.4-0.4-0.30.30.3-0.6-0.3-0.50.60.1-0.10.30.6
Patch foraging water rate 0 sec0.31.01.81.31.4-1.1-1.20.81.11.1-0.8-0.80.7-0.7-0.9
Patch foraging water rate 12 sec0.20.93.21.10.7-0.5-1.1-0.20.30.9-1.8-1.01.0-0.9-0.9
Patch foraging water rate 18 sec1.53.24.72.12.0-2.0-2.12.12.21.8-1.6-1.11.0-1.3-1.8
Patch foraging water rate 24 sec0.00.10.30.1-0.4-0.1-0.00.10.1-0.2-0.60.3-0.30.2-0.1
Patch foraging water rate 6 sec1.01.53.11.71.4-1.1-1.30.50.61.3-1.8-1.11.1-1.2-1.1
Seeking ratio, delayed vs. immediate footshock0.30.41.10.10.20.1-0.4-1.0-0.90.1-0.4-0.90.9-0.5-0.2
Distance traveled before self-admin0.10.31.00.30.30.8-0.10.10.00.4-1.0-0.50.5-0.8-0.5
Distance traveled after self-admin0.20.31.01.00.8-0.4-0.30.60.80.4-0.6-0.00.0-0.2-0.1
Extensor digitorum longus weight4.317.333.25.24.7-5.6-4.65.85.23.6-3.0-1.81.7-2.2-3.6
Bone: elastic displacement0.30.42.40.2-0.00.50.1-1.5-1.1-0.1-0.7-0.40.5-0.30.3
Bone: elastic work0.60.81.91.41.3-0.7-0.9-0.80.20.8-1.0-1.01.0-0.9-0.3
Bone: endosteal estimation0.10.10.8-0.20.00.50.5-0.9-0.30.00.40.0-0.0-0.10.4
Bone: endosteal perimeter0.20.52.9-0.4-0.31.20.7-1.7-0.9-0.1-0.0-0.20.3-0.30.5
Epididymis fat weight0.00.20.60.40.1-0.3-0.1-0.40.3-0.70.30.3-0.30.60.7
Delta time in closed arm before/after self-admin0.30.30.9-0.8-0.60.70.5-0.9-0.4-0.60.80.00.00.30.4
Delta time in open arm before/after self-admin0.20.20.70.40.4-0.5-0.60.80.10.5-0.4-0.30.3-0.3-0.5
Diff in mean of infusions in LGA sessions3.36.09.32.82.8-2.7-3.01.92.72.4-2.0-2.32.2-2.0-2.2
Delay discount exponential model param2.02.76.8-2.5-2.32.61.7-2.3-2.4-0.4-0.1-0.30.3-0.5-0.0
Extinction: sum of active levers before priming0.10.10.60.30.8-0.1-0.3-0.20.30.40.6-0.10.20.00.1
Active lever presses in extinction session 61.01.01.7-0.9-0.90.81.1-0.2-0.3-1.01.01.3-1.31.31.1
Bone: final force0.30.51.91.21.2-1.4-0.70.40.80.20.20.2-0.20.30.2
Bone: final moment0.40.61.81.31.3-1.3-0.80.30.80.5-0.2-0.20.2-0.1-0.1
Food consumed during 24 hour testing period0.10.30.80.50.40.0-0.3-0.10.20.6-0.9-0.60.6-0.8-0.6
Glucose0.30.51.50.0-0.2-0.60.30.80.2-0.70.71.2-1.21.10.6
Heart weight0.10.10.2-0.3-0.40.40.1-0.4-0.5-0.2-0.4-0.20.2-0.2-0.1
Delay discount hyperbolic model param1.92.45.8-2.4-2.22.41.6-2.1-2.3-0.40.0-0.20.2-0.40.0
Intermittent access intake day 1-15 change0.21.01.7-1.2-1.31.21.3-1.2-1.3-0.90.60.6-0.60.61.0
Intermittent access intake escalation0.10.40.9-0.8-0.90.80.9-0.7-0.9-0.50.40.3-0.20.30.6
Intermittent access intake escalation 20.10.10.5-0.4-0.70.40.4-0.3-0.5-0.3-0.40.0-0.0-0.00.2
Intermitt. access day 1 inactive lever presses0.00.51.8-1.3-1.11.10.4-0.4-1.0-0.20.4-0.40.4-0.1-0.2
Intermitt. access day 15 inactive lever presses0.21.02.7-0.3-0.00.1-0.61.40.31.4-1.0-1.21.1-1.2-1.6
Intermitt. access escalation Index0.10.30.7-0.4-0.40.40.4-0.8-0.8-0.60.70.3-0.20.30.6
Intermittent access day 1 total infusions0.41.11.6-0.9-0.80.91.2-0.7-0.8-1.11.31.2-1.21.11.2
Intermittent access day 15 total infusions0.92.13.2-1.7-1.71.61.8-1.2-1.6-1.51.21.2-1.21.11.4
Intermittent access terminal intake (last 3 days)1.32.33.9-1.8-2.01.61.9-0.9-1.6-1.70.81.5-1.51.21.3
Intermittent access total infusions3.13.75.4-2.2-2.21.82.3-1.4-1.7-2.11.71.9-1.91.81.9
Intermittent access day 1 locomotion0.10.10.60.20.6-0.3-0.20.10.30.00.80.1-0.10.30.2
Intermittent access day 15 total locomotion0.10.40.9-0.7-1.00.70.8-0.1-0.6-0.70.20.7-0.70.50.5
Intermittent access total locomotion0.10.20.3-0.5-0.50.50.4-0.1-0.5-0.60.30.3-0.30.40.3
Intermittent access standard deviation0.20.92.1-0.6-1.51.01.2-0.5-0.8-1.1-0.91.0-1.00.50.7
Left kidney weight0.53.95.81.72.0-1.6-2.11.71.62.4-1.9-2.02.0-2.1-2.2
Right kidney weight1.17.911.92.33.0-2.0-3.12.02.13.4-2.5-3.33.3-3.1-3.1
Cocaine induced anxiety0.51.52.51.51.3-1.1-1.60.31.11.0-1.4-1.31.3-1.1-1.0
Post-drug Anxiety1.82.03.81.21.6-0.8-1.6-0.20.61.6-1.2-1.92.0-1.7-1.3
Baseline Anxiety0.10.10.5-0.30.40.00.2-0.3-0.20.30.70.0-0.00.00.1
Tail length0.10.71.8-0.20.40.6-0.2-0.5-0.31.2-0.6-1.31.3-1.3-0.9
Length with tail0.73.05.21.41.8-1.0-1.70.21.12.1-1.7-2.32.3-2.1-1.7
Length without tail1.15.68.72.92.9-2.6-2.81.82.62.2-2.2-2.12.0-1.9-1.9
Times rat made contact with spout0.10.10.2-0.4-0.40.30.5-0.1-0.2-0.40.40.5-0.50.40.3
Lifetime Intake2.83.55.1-2.1-2.21.92.3-1.3-1.7-2.11.61.8-1.81.71.8
Liver weight, left2.34.15.52.01.8-1.3-2.21.31.92.1-2.3-2.22.2-2.3-2.2
Liver weight, right0.71.33.21.41.4-1.8-1.21.81.31.0-0.2-0.10.0-0.3-0.9
Locomotor activity4.36.79.73.02.9-2.0-2.90.72.12.7-3.1-2.92.9-2.7-2.3
Locomotor testing distance1.02.45.51.31.30.0-1.3-1.80.11.3-1.9-2.32.3-1.9-0.9
Locomotor testing rearing1.03.89.41.01.40.6-1.2-2.1-0.61.9-2.0-3.03.1-2.7-1.4
Locomotion in novel chamber0.30.41.00.41.0-0.9-0.50.70.61.01.0-0.30.3-0.3-0.4
Locomotion in novel chamber post-restriction0.10.40.90.40.1-0.60.20.00.1-0.50.91.0-1.00.80.7
Fecal boli incidents, locomotor time 10.10.21.00.5-0.1-0.20.10.6-0.1-0.4-1.00.4-0.50.00.1
Change in fecal boli incidents, locomotor task0.30.30.8-0.3-0.10.2-0.50.20.40.6-0.4-0.80.8-0.6-0.9
Time >=10cm from walls, locomotor time 10.91.12.40.40.60.0-0.90.00.61.2-1.2-1.51.5-1.4-1.3
Bouts of movement, locomotor time 10.10.20.6-0.1-0.70.20.30.20.0-0.8-0.40.5-0.50.30.2
Total resting periods, locomotor time 10.70.81.9-0.5-1.20.40.80.2-0.1-1.40.11.2-1.21.00.8
Rest time, locomotor task time 10.81.33.0-0.8-0.90.11.20.1-0.5-1.21.01.7-1.71.61.3
Distance moved, locomotor task time 10.10.20.6-0.00.20.3-0.3-0.40.20.4-0.3-0.70.7-0.6-0.4
Vertical activity count, locomotor time 10.21.42.21.21.4-0.7-1.1-0.20.71.4-1.2-1.51.5-1.5-1.1
Time >=10cm from walls, locomotor time 20.20.61.10.00.20.4-0.40.40.70.9-1.0-1.00.9-1.0-1.0
Bouts of movement, locomotor time 20.20.82.61.10.6-1.3-0.81.41.60.0-0.70.3-0.30.3-0.2
Total resting periods, locomotor time 20.21.03.21.10.7-1.4-0.91.81.80.1-0.60.5-0.50.4-0.3
Rest time, locomotor task time 20.91.64.20.5-0.1-1.30.32.01.1-0.70.52.0-2.01.60.7
Distance moved, locomotor task time 20.30.42.1-0.20.30.80.1-1.5-0.50.30.1-0.90.9-0.6-0.0
Vertical activity count, locomotor time 20.20.41.30.51.0-0.1-0.2-1.1-0.30.80.1-0.80.8-0.7-0.1
Light reinforcement 10.00.10.5-0.3-0.00.10.2-0.3-0.20.00.70.2-0.20.40.4
Light reinforcement 20.40.81.5-1.2-1.10.71.00.2-0.5-0.81.11.1-1.21.00.6
Bone: marrow area0.10.21.0-0.3-0.10.60.6-1.0-0.4-0.10.40.1-0.10.00.5
Bone: maximum diameter0.20.40.80.60.3-0.70.1-0.10.2-0.60.50.9-0.90.90.8
Bone: maximum force0.40.92.71.61.5-1.6-0.70.31.20.20.40.4-0.40.40.4
Bone: maximum moment0.50.93.11.71.7-1.6-0.90.21.20.60.0-0.00.0-0.00.1
Mean time between licks in bursts0.31.75.4-1.9-1.32.31.3-1.9-1.7-0.20.7-0.40.4-0.30.4
Mean num. licks in bursts0.10.30.8-0.5-0.70.90.6-0.9-0.7-0.3-0.40.1-0.1-0.10.2
Cd content in liver2.22.54.71.21.2-0.4-1.40.50.81.9-2.0-2.02.0-2.2-1.9
Co content in liver0.30.41.20.80.4-1.1-0.51.10.7-0.1-0.60.4-0.50.2-0.3
Cu content in liver0.30.30.90.60.5-0.8-0.60.90.40.6-0.2-0.20.2-0.3-0.6
Fe content in liver0.50.61.5-0.9-0.91.20.4-1.1-1.1-0.2-0.3-0.60.6-0.4-0.1
K content in liver0.40.41.0-1.0-0.70.60.7-0.3-0.7-0.50.90.5-0.50.60.5
Mg content in liver1.41.53.0-1.6-1.31.61.5-1.5-1.7-0.91.10.7-0.60.61.0
Mn content in liver1.31.53.3-1.2-0.91.21.3-1.8-1.7-1.01.30.7-0.70.81.3
Na content in liver5.56.29.53.13.0-2.7-2.92.02.32.5-2.5-2.22.1-2.1-2.2
Rb content in liver0.30.41.1-0.8-0.81.10.2-0.0-0.20.3-0.5-0.60.6-0.7-0.6
Se content in liver0.70.82.20.50.50.2-0.6-1.4-0.60.6-1.0-1.41.5-1.0-0.4
Sr content in liver0.50.50.9-0.5-0.20.90.1-0.6-0.90.6-0.7-0.80.9-0.9-0.5
Zn content in liver0.30.41.2-0.6-0.41.10.5-1.1-0.90.10.0-0.40.4-0.40.1
Bone: minimum diameter0.10.21.21.10.7-0.7-0.3-0.6-0.0-0.2-0.30.1-0.10.20.4
Time in familiar zone, hab. session 10.80.91.5-0.6-0.80.40.9-0.9-0.7-1.20.91.1-1.11.21.2
Time in novel zone, hab. session 11.21.33.71.11.0-1.3-1.21.91.41.1-0.8-0.50.5-0.7-1.2
Total zone transitions, hab. session 10.20.30.80.90.8-0.8-0.2-0.20.6-0.20.40.4-0.40.50.6
Total locomotion distance, hab. session 10.30.41.20.40.4-0.20.3-0.90.1-0.50.90.5-0.50.71.1
Locomotion velocity, hab. session 10.20.31.40.60.8-0.20.0-1.20.1-0.10.80.00.00.30.9
Time in familiar zone, hab. session 20.30.30.6-0.7-0.70.40.60.0-0.7-0.50.40.6-0.60.50.2
Time in novel zone, hab. session 20.10.10.40.40.4-0.2-0.1-0.20.6-0.10.1-0.00.00.10.3
Total zone transitions, hab. session 20.30.41.31.21.0-0.7-0.7-0.00.50.5-0.6-0.50.5-0.5-0.2
Total locomotion distance, hab. session 20.10.10.30.60.5-0.3-0.1-0.40.1-0.20.30.1-0.10.30.5
Locomotion velocity, hab. session 20.20.20.80.90.9-0.6-0.3-0.20.40.00.20.0-0.00.10.4
Novel to familiar place preference ratio0.40.51.1-0.3-0.50.60.8-0.8-0.4-1.00.50.6-0.60.71.1
Novelty place preference0.30.30.8-0.2-0.50.60.7-0.8-0.3-0.80.30.4-0.40.50.9
Time in novel zone, NPP test0.10.10.4-0.1-0.30.50.4-0.6-0.1-0.60.00.2-0.20.30.6
Total zone transitions, NPP test0.10.20.90.40.5-0.10.0-1.00.1-0.10.4-0.10.10.10.6
Total locomotion distance, NPP test1.01.35.5-0.9-0.51.31.1-2.3-1.3-0.81.40.2-0.10.51.4
Locomotion velocity, NPP test1.11.65.3-1.1-0.61.41.3-2.3-1.4-0.91.60.5-0.40.71.5
Intraocular pressure0.91.54.5-1.4-1.32.01.2-2.1-2.0-0.60.1-0.20.3-0.20.5
Delta distance traveled before/after self-admin0.40.51.80.90.8-1.3-0.61.00.90.3-0.20.1-0.10.2-0.0
Delta ambulatory time before/after self-admin0.20.31.30.90.6-1.2-0.30.60.9-0.10.00.4-0.40.40.3
Parametrial fat weight1.84.310.6-1.9-1.81.92.2-3.3-2.5-2.01.91.4-1.31.52.2
Pavlov. Cond. lever latency0.70.81.7-1.3-1.11.21.1-0.8-1.2-0.60.80.7-0.70.50.5
Pavlov. Cond. magazine entry latency0.60.81.30.80.6-0.8-1.10.90.90.8-1.1-1.01.0-0.8-1.0
Pavlov. Cond. change in total contacts1.92.04.82.21.9-2.0-1.61.32.01.0-1.0-0.70.7-0.6-0.7
Pavlov. Cond. index score2.32.94.52.01.9-2.1-2.11.81.91.5-1.3-1.41.3-1.2-1.4
Pavlov. Cond. latency score1.72.13.31.71.6-1.8-1.81.51.71.2-1.2-1.21.2-1.0-1.2
Pavlov. Cond. lever contacts0.91.11.91.41.2-1.4-1.31.01.40.7-0.9-0.80.8-0.6-0.7
Pavlov. Cond. magazine entry number1.92.43.5-1.7-1.61.81.9-1.7-1.6-1.41.51.3-1.21.21.5
Pavlov. Cond. intertrial magazine entries0.20.20.40.40.6-0.0-0.3-0.50.10.4-0.2-0.60.7-0.5-0.1
Pavlov. Cond. lever-magazine prob. diff.2.63.35.12.12.1-2.3-2.22.02.11.6-1.4-1.41.3-1.2-1.5
Pavlov. Cond. response bias1.62.03.21.71.4-1.8-1.71.71.81.2-1.2-1.01.0-0.9-1.2
Pavlov. Cond. lever latency1.82.53.9-1.5-1.60.91.5-0.7-0.8-2.02.01.8-1.72.01.8
Pavlov. Cond. magazine entry latency1.01.42.71.61.6-1.6-1.50.91.31.1-0.6-0.90.9-0.7-0.8
Pavlov. Cond. change in total contacts2.04.96.32.42.3-1.9-2.41.81.92.5-2.5-2.12.0-2.3-2.4
Pavlov. Cond. index score2.23.44.32.02.0-1.6-2.11.31.62.1-1.9-1.81.8-1.9-1.9
Pavlov. Cond. latency score2.33.64.62.02.1-1.6-2.11.21.52.2-2.1-2.02.0-2.0-2.0
Pavlov. Cond. lever contacts1.62.43.91.51.6-0.9-1.50.70.92.0-1.8-1.71.7-1.9-1.7
Pavlov. Cond. magazine entry number0.30.41.2-1.1-1.11.00.8-0.2-0.9-0.50.10.3-0.30.20.1
Pavlov. Cond. intertrial magazine entries2.96.413.1-3.2-2.83.63.0-3.5-2.8-2.11.81.1-1.01.12.1
Pavlov. Cond. lever-magazine prob. diff.2.03.14.22.02.0-1.7-2.01.31.61.9-1.7-1.61.6-1.6-1.7
Pavlov. Cond. response bias1.72.43.71.81.9-1.4-1.70.91.31.8-1.5-1.51.5-1.6-1.5
Time in closed arm before self-admin0.91.52.91.01.2-1.2-1.51.71.11.3-0.9-1.11.1-1.1-1.4
Time in closed arm after self-admin0.10.10.40.20.3-0.4-0.5-0.00.30.30.1-0.60.6-0.3-0.3
Time in open arm before self-admin0.50.62.3-0.5-0.50.90.9-1.5-0.3-0.60.90.4-0.40.51.0
Time in open arm after self-admin0.10.10.3-0.10.20.3-0.10.3-0.00.6-0.1-0.30.3-0.4-0.4
Bone: periosteal estimation0.10.20.50.40.4-0.30.2-0.7-0.1-0.20.60.4-0.40.40.7
Bone: periosteal perimeter0.10.10.90.30.20.00.2-0.9-0.2-0.20.10.1-0.10.20.6
Bone: post-yield work3.45.813.0-0.8-1.1-0.22.0-0.4-0.4-2.83.13.6-3.63.43.0
Progressive ratio test 1 active lever presses1.22.13.6-1.3-1.31.01.6-0.3-0.7-1.51.71.9-1.91.71.5
Progressive ratio test 1 breakpoint1.11.93.4-1.2-1.20.91.5-0.3-0.6-1.41.61.8-1.81.61.4
Progressive ratio test 1 inactive lever presses0.20.61.7-1.3-0.71.20.7-0.7-1.1-0.31.3-0.00.00.10.2
Progressive ratio test 2 active lever presses0.50.71.6-1.1-1.21.31.2-0.4-1.2-0.70.10.6-0.60.30.5
Progressive ratio test 2 breakpoint0.40.51.2-0.9-0.91.11.0-0.3-1.0-0.5-0.00.5-0.50.20.3
Progressive ratio test 2 inactive lever presses0.41.23.4-1.9-1.61.81.4-0.3-1.3-0.70.80.4-0.40.30.3
Incentive Sensitization - Responses0.30.72.00.0-0.10.9-0.0-0.2-0.90.6-1.4-1.01.1-1.3-0.8
Incentive Sensitization - Breakpoint0.30.71.9-0.0-0.10.9-0.0-0.3-0.90.7-1.4-1.11.1-1.3-0.8
Sum of active levers in priming session hrs 5-60.20.20.7-0.5-0.20.20.30.1-0.0-0.30.80.5-0.50.70.4
Progressive ratio0.61.62.31.31.5-1.3-1.41.41.11.4-0.9-1.11.1-1.3-1.4
Food seeking constrained by brief footshock0.70.81.4-1.1-1.20.50.80.7-0.3-1.00.71.2-1.21.10.5
Seeking ratio, punishment vs. effort0.61.32.2-1.1-1.40.91.1-0.3-0.7-1.40.71.3-1.31.51.1
Retroperitoneal fat weight0.31.32.7-1.0-0.90.81.2-1.6-1.0-1.21.40.8-0.81.01.4
Reaction time number correct0.10.31.1-0.8-0.81.00.6-0.7-0.8-0.2-0.0-0.00.0-0.2-0.0
Reaction time mean minus median0.21.41.91.11.1-1.0-1.30.60.91.1-1.4-1.41.4-1.3-1.2
Reaction time mean minus median AUC0.10.91.70.60.8-0.6-1.00.40.51.0-0.9-1.31.3-1.3-1.2
Reaction time num false alarms0.81.43.11.11.8-0.9-1.20.91.51.6-0.4-1.21.2-1.1-1.0
Reaction time num false alarms AUC0.61.32.71.21.6-1.0-1.11.01.41.3-0.6-1.01.0-1.0-0.9
Reaction time trials correct on left0.10.31.1-0.8-0.81.00.6-0.7-0.8-0.2-0.0-0.00.0-0.2-0.0
Reaction time trials on left0.10.41.3-0.9-0.91.20.7-0.8-0.9-0.20.00.0-0.0-0.2-0.0
Reaction time mean0.20.51.40.10.10.1-0.40.3-0.10.8-1.2-0.90.9-1.1-1.1
Reaction time mean AUC0.40.92.10.30.4-0.1-0.70.40.11.1-1.4-1.21.2-1.4-1.4
Median of all reaction times0.20.41.1-0.2-0.20.4-0.10.3-0.30.6-1.0-0.60.6-0.9-0.9
Reaction time omissions0.71.13.3-1.7-1.31.81.2-1.5-1.4-0.30.4-0.20.2-0.30.2
Reaction time false alarm rate1.01.33.01.31.7-1.4-1.21.31.71.2-0.3-0.70.7-0.6-0.7
Reaction time premature initiation rate0.20.30.70.80.3-0.8-0.60.80.4-0.0-0.80.0-0.10.1-0.3
Reaction time premature initiations0.00.10.40.2-0.3-0.1-0.10.2-0.3-0.3-0.60.2-0.20.2-0.1
Std. dev. reaction times0.10.31.00.20.1-0.2-0.50.30.20.4-1.0-0.70.7-0.7-0.7
Reaction time trials completed0.10.41.3-0.9-0.91.20.7-0.8-0.9-0.20.00.0-0.0-0.2-0.0
Reaction time trials AUC0.10.51.6-1.0-0.91.30.7-0.9-1.0-0.2-0.00.00.0-0.20.0
Run reversals in cocaine runway, females0.70.72.2-0.8-0.40.50.9-0.7-0.4-0.31.51.0-1.01.10.9
Run reversals in cocaine runway, males1.71.94.41.91.5-2.0-1.42.11.70.9-1.3-0.10.1-0.4-1.0
Latency to leave start box in cocaine runway0.91.33.1-1.2-1.71.81.2-1.0-1.8-1.1-0.50.4-0.40.10.4
Latency to leave start box in cocaine runway, F0.30.41.4-0.2-0.80.70.2-0.0-1.1-0.5-1.2-0.20.2-0.5-0.4
Latency to leave start box in cocaine runway, M0.90.82.3-1.2-1.21.51.1-1.3-1.2-0.40.10.2-0.1-0.00.3
Std. dev. time between licks in bursts0.50.94.4-0.6-0.31.50.6-2.1-1.0-0.0-0.0-0.90.9-0.60.4
Total sessions with >9 infusions0.50.61.3-1.2-0.91.01.0-0.4-0.9-0.51.00.5-0.50.30.4
Short access day 1 total inactive lever presses0.30.51.2-0.6-1.10.40.80.3-0.3-0.90.41.1-1.10.60.4
Short access day 10 total inactive lever presses0.10.40.6-0.7-0.80.70.7-0.5-0.8-0.70.40.4-0.40.40.5
Short access day 1 total infusions1.73.35.6-2.1-2.42.02.2-1.2-2.1-1.91.41.7-1.71.31.4
Short access day 10 total infusions0.20.30.7-0.1-0.20.20.6-0.20.0-0.60.50.8-0.80.70.8
Short access total infusions0.81.11.7-1.0-1.21.11.3-0.7-0.9-1.30.61.1-1.10.91.0
Short access day 1 locomotion0.00.10.30.10.30.1-0.10.2-0.30.40.1-0.30.3-0.5-0.3
Short access day 10 total locomotion0.10.30.60.30.5-0.1-0.60.3-0.00.6-0.4-0.80.8-0.8-0.7
Short access total locomotion0.20.30.60.40.7-0.3-0.50.50.10.7-0.3-0.60.6-0.7-0.6
One hour access (0.3 mA shock)2.22.65.0-1.1-1.10.91.7-1.2-1.3-1.82.21.8-1.81.82.0
Compulsive drug intake0.30.54.2-0.40.40.00.2-0.6-0.4-0.02.00.1-0.10.50.6
One hour access (shock baseline)0.71.82.7-1.2-1.61.31.7-1.0-1.3-1.60.61.4-1.41.21.4
Social response proportion1.31.64.9-1.9-2.21.81.5-0.7-1.3-1.40.20.7-0.70.50.6
Social responses2.22.96.8-1.9-2.12.41.7-2.6-2.1-2.00.40.5-0.40.71.4
Social time0.81.23.00.10.70.6-0.6-0.3-0.21.4-1.1-1.71.7-1.7-1.3
Soleus weight0.10.41.20.60.5-1.1-0.41.10.7-0.10.40.5-0.50.5-0.0
Bone: stiffness0.51.02.61.31.3-1.5-1.01.31.60.7-0.2-0.20.1-0.2-0.5
Tibialis anterior weight4.816.527.94.94.9-5.3-4.65.35.13.8-2.4-2.12.0-2.4-3.5
Time to tail flick, vehicle, before self-admin0.50.71.80.81.0-1.3-1.00.81.40.90.1-0.30.30.0-0.5
Time to tail flick, vehicle, after self-admin0.40.93.40.70.5-1.2-0.91.81.31.0-0.7-0.0-0.0-0.1-0.9
Time to tail flick, test, before self-admin0.20.21.4-0.10.6-0.0-0.0-0.5-0.30.61.2-0.20.2-0.10.1
Time to tail flick, test, after self-admin3.13.36.8-2.6-2.42.12.1-2.2-2.4-1.31.70.9-0.80.81.0
Delta time to tail flick, vehicle, before/after SA0.40.41.4-0.8-1.20.70.70.2-0.7-0.4-0.40.6-0.60.2-0.0
Delta time to tail flick, test, before/after SA1.92.46.1-2.4-2.52.01.8-1.2-1.7-1.40.61.0-1.00.80.7
Tibia length2.46.712.22.02.9-1.2-2.60.51.73.3-2.2-3.53.5-3.1-2.6
Ambulatory time before self-admin0.00.10.40.20.10.60.1-0.10.10.1-0.5-0.00.0-0.3-0.1
Ambulatory time after self-admin0.60.92.71.61.2-1.1-0.81.01.30.7-0.9-0.20.2-0.4-0.3
Bone: tissue strength0.20.20.7-0.20.10.60.4-0.8-0.60.20.2-0.00.1-0.30.1
Total heroin consumption0.60.72.01.00.8-1.2-0.71.41.10.6-0.90.0-0.1-0.2-0.5
Bone: trabecular number0.40.82.2-1.3-0.71.50.9-1.4-1.2-0.10.8-0.30.3-0.10.3
Bone: trabecular spacing0.91.34.41.71.3-2.1-1.21.61.60.3-0.30.2-0.30.3-0.3
Bone: trabecular thickness0.10.20.70.50.9-0.6-0.3-0.10.50.30.5-0.10.10.00.1
Bone: trabecular tissue density1.93.45.92.21.9-2.4-2.32.42.41.4-1.6-1.11.0-1.0-1.6
Water consumed over 24 hours0.40.81.21.11.1-1.0-0.91.01.11.0-0.8-0.60.5-0.7-0.8
Number of responses in last shaping day0.40.51.31.10.7-1.1-0.71.10.80.2-0.70.1-0.1-0.1-0.2