Hub : Genes

Efemp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio NM_001005907.2 0.02 0.02 7.3e-03 0.02 0.02 0.01 0.01 5.5e-03 4.7e-03 4.2e-02 1.2e-02
2 RMTg intron excision ratio chr1_202782491_202782781 0.15 0.1 7.0e-03 0.05 0.06 0.05 0.06 1.8e-02 1.0e-02 1.4e-02 1.3e-02
3 NAcc mRNA stability Efemp2 0.04 0.03 6.3e-05 0.04 0.03 0.03 0.03 1.7e-05 1.9e-04 4.8e-04 2.2e-04
4 NAcc gene expression Efemp2 0.08 0.05 4.7e-10 0.08 0.09 0.08 0.09 6.2e-10 6.3e-11 1.9e-09 3.7e-10
5 NAcc alternative TSS XM_006230743.2 0.05 0.03 4.0e-05 0.03 0.04 0.03 0.04 3.5e-04 2.4e-05 2.5e-04 6.0e-05
6 NAcc alternative TSS XM_006230743.2 0.05 0.04 1.6e-05 0.03 0.04 0.04 0.04 1.6e-04 8.3e-06 2.1e-05 1.4e-05
7 Brain intron excision ratio chr1_202785726_202785838 0.03 0.02 5.4e-03 0.01 0.01 0.01 -0 4.9e-02 5.4e-02 9.0e-02 5.2e-01
8 RMTg mRNA stability Efemp2 0.14 0.09 1.9e-03 0.1 0.05 0.06 0.07 1.5e-03 1.8e-02 1.1e-02 6.3e-03
9 Eye intron excision ratio chr1_202784023_202785247 0.65 0.16 8.9e-03 -0.02 -0.02 -0.02 0.02 7.1e-01 8.3e-01 9.1e-01 1.5e-01
10 LHb intron excision ratio chr1_202785957_202787634 0.18 0.12 9.4e-03 0.06 0.02 0 0.04 1.7e-02 1.1e-01 3.0e-01 4.3e-02
11 LHb intron excision ratio chr1_202787422_202787634 0.48 0.2 3.1e-04 0.16 0.15 0.14 0.12 1.1e-04 2.6e-04 4.0e-04 8.8e-04
12 LHb isoform ratio NM_001005907.2 0.47 0.18 8.3e-03 0.07 0.07 0.13 0.13 8.5e-03 1.1e-02 4.6e-04 6.2e-04
13 PL gene expression Efemp2 0.05 0.03 5.4e-05 0.05 0.04 0.04 0.04 4.0e-06 1.9e-05 2.9e-05 1.5e-05
14 Adipose gene expression Efemp2 0.12 0.07 2.4e-06 0.04 0.04 0.05 0.04 1.3e-05 6.2e-05 1.8e-06 5.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.23.71.3-0.7-0.8-0.31.01.0-0.90.4-0.2-1.81.90.5-1.90.6
Area under the delay curve0.60.61.70.10.30.30.51.11.1-0.70.21.2-0.80.80.5-0.51.3
BMI with tail2.99.429.14.3-2.9-2.5-1.81.01.1-1.31.40.6-4.94.92.6-5.42.3
BMI without tail1.22.56.22.2-1.5-1.1-0.90.70.8-0.50.61.0-2.52.41.9-2.51.3
Body weight2.08.521.24.6-4.3-4.1-3.7-1.9-1.81.5-1.3-0.9-2.72.72.9-3.70.8
Weight adjusted by age1.61.83.21.6-1.8-1.8-1.8-1.6-1.61.3-0.8-1.6-0.50.50.6-0.6-1.4
Bone surface2.34.110.03.2-2.7-2.8-2.4-0.9-0.90.4-0.7-2.2-2.52.50.6-2.6-0.1
Bone volume1.22.05.32.1-1.4-1.7-1.10.00.0-0.60.1-1.7-2.32.3-0.2-2.10.1
Breakpoint value in progressive ratio session2.12.34.72.1-2.1-2.2-2.0-1.6-1.51.0-1.3-2.0-1.11.10.4-0.6-0.8
Number of licking bursts0.20.20.50.7-0.6-0.7-0.6-0.4-0.4-0.20.0-0.7-0.60.60.10.2-0.0
Context. condit. distance diff. score1.21.43.0-1.51.71.71.71.51.4-1.10.91.10.6-0.6-0.60.10.2
Locomotion velocity, session 10.20.30.8-0.1-0.10.0-0.2-0.3-0.30.7-0.60.60.9-0.90.7-0.30.1
Locomotion distance, session 10.70.93.31.2-0.8-0.8-0.40.60.6-0.30.50.7-0.80.81.4-1.81.1
Locomotion velocity, session 21.72.04.72.2-2.0-2.0-1.7-0.7-0.70.7-0.5-0.4-1.51.51.5-1.80.7
Locomotion distance, session 20.71.02.91.4-1.1-1.1-0.70.20.30.10.20.8-0.90.91.7-1.61.1
Locomotion velocity, session 30.60.72.70.10.30.30.61.11.1-0.90.90.7-0.80.90.5-1.70.8
Locomotion distance, session 30.00.00.0-0.10.20.10.20.20.2-0.00.00.20.2-0.00.1-0.20.1
Stereotopy head waving bouts, day 31.11.23.6-0.50.80.91.11.51.5-1.01.51.5-0.40.30.4-1.90.8
Stereotopy head waving duration, day 30.70.81.7-0.81.01.11.21.31.3-1.01.20.8-0.30.1-0.2-0.80.5
Locomotion velocity, session 71.61.83.50.10.60.71.11.81.8-1.81.80.9-1.51.5-0.0-1.90.9
Locomotion distance, session 70.50.62.40.20.10.30.51.01.0-0.60.51.3-0.40.30.9-1.50.7
Stereotopy head waving bouts, day 70.60.61.8-0.10.50.30.60.70.7-1.01.1-0.7-1.31.3-1.0-0.40.1
Stereotopy head waving duration, day 70.91.14.01.4-1.0-1.2-0.80.00.0-0.30.3-1.1-2.02.0-0.0-0.80.3
Locomotion velocity, session 80.91.12.40.8-1.2-1.2-1.3-1.1-1.11.5-1.60.20.3-0.41.5-0.7-0.1
Locomotion distance, session 80.50.72.4-0.10.50.50.81.11.1-0.91.30.7-0.60.50.0-1.50.6
Degree of sensitization distance0.50.52.30.30.00.10.30.80.8-0.60.81.1-0.40.30.6-1.50.6
Degree of sensitization stereotypy0.70.82.90.9-0.6-0.8-0.5-0.2-0.2-0.30.3-1.5-1.71.7-0.7-0.3-0.2
Conditioned locomotion1.11.22.31.3-1.5-1.5-1.5-1.3-1.31.1-1.2-0.60.1-0.11.1-1.1-0.3
Cocaine response after cond. corrected1.01.13.1-1.41.31.21.31.11.1-0.50.41.80.9-0.80.3-0.20.6
Cocaine response after cond. not corrected0.80.82.5-1.21.11.11.21.01.0-0.50.51.60.8-0.70.2-0.30.6
Cocaine response before conditioning0.50.51.81.0-0.9-1.0-0.9-0.7-0.70.3-0.1-1.3-0.70.8-0.2-0.1-0.2
Saline control response2.22.96.72.4-2.6-2.4-2.5-1.6-1.51.8-1.1-0.4-0.50.52.1-1.5-0.1
Bone: connectivity density1.52.35.62.4-1.9-2.0-1.40.00.1-0.1-0.4-0.8-2.22.21.1-2.30.4
Bone: cortical apparent density0.20.30.80.5-0.6-0.5-0.6-0.5-0.50.4-0.70.1-0.1-0.00.50.90.2
Bone: cortical area0.60.82.31.0-1.1-1.3-1.1-1.1-1.10.4-0.7-1.5-0.40.3-0.1-0.8-0.6
Bone: cortical porosity0.30.31.30.6-0.3-0.3-0.10.50.5-0.40.00.2-1.21.10.4-0.40.2
Bone: cortical porosity0.40.41.21.0-0.8-0.7-0.60.00.00.1-0.50.2-1.11.10.8-0.60.1
Bone: cortical thickness2.33.87.91.8-2.4-2.6-2.5-2.6-2.62.2-2.8-1.10.5-0.51.60.1-0.9
Bone: cortical thickness1.21.44.50.5-1.0-1.0-1.1-1.3-1.31.5-2.10.41.5-1.41.40.4-0.1
Bone: cortical tissue density0.30.30.90.6-0.7-0.6-0.7-0.6-0.60.6-0.80.1-0.0-0.10.60.90.2
Condit. Reinf. active minus inactive responses0.10.20.60.6-0.5-0.8-0.30.10.1-0.00.30.2-0.50.50.5-0.10.3
Condit. Reinf. active-inactive response ratio0.10.10.40.2-0.1-0.5-0.10.00.00.1-0.2-0.1-0.10.10.10.70.1
Condit. Reinf. active responses0.20.20.60.5-0.2-0.6-0.00.30.3-0.50.80.0-0.50.60.1-0.60.3
Condit. Reinf. inactive responses0.40.52.20.20.20.00.40.60.6-1.01.20.1-0.40.5-0.4-1.50.4
Incentive salience index mean0.40.40.91.0-0.6-0.8-0.30.30.3-0.30.60.3-0.90.90.6-0.90.6
Condit. Reinf. lever presses0.20.31.50.9-0.7-0.7-0.5-0.2-0.2-0.20.5-0.3-0.50.60.1-1.20.4
Condit. Reinf. active minus inactive responses0.30.41.1-0.20.40.20.50.50.5-0.81.0-1.0-0.70.6-1.00.2-0.3
Condit. Reinf. active-inactive response ratio1.11.23.6-0.51.00.71.00.80.8-1.61.9-1.3-0.90.9-1.8-0.2-0.2
Condit. Reinf. active responses0.20.31.00.5-0.1-0.3-0.00.50.5-0.50.7-0.5-1.00.9-0.2-0.00.2
Condit. Reinf. inactive responses0.40.41.70.8-0.7-0.7-0.50.40.40.3-0.40.9-0.60.41.3-0.20.7
Condit. Reinf. lever presses1.52.04.42.0-1.8-2.1-1.7-1.2-1.10.5-0.4-2.0-1.61.5-0.0-0.7-0.6
Condit. Reinf. lever reinforcers received0.20.30.90.8-0.5-0.7-0.40.10.1-0.20.4-0.8-1.00.9-0.20.1-0.0
Conditioned reinforcement - actives0.40.41.9-0.60.50.60.3-0.2-0.2-0.10.5-0.90.4-0.4-1.40.6-1.1
Conditioned reinforcement - inactives3.84.210.0-2.92.92.62.61.51.4-1.91.4-0.91.3-1.3-3.22.1-0.7
Conditioned locomotion4.65.513.1-3.63.43.53.01.51.4-1.51.60.42.1-2.1-2.82.3-0.4
Patch foraging indifference point 0 sec0.00.10.2-0.20.20.40.30.40.4-0.4-0.00.00.0-0.0-0.3-0.20.2
Patch foraging indifference point AUC2.42.75.02.1-2.2-2.2-2.2-1.8-1.81.5-1.9-2.2-0.80.90.5-0.2-0.5
Delay disc. indifference point, 0s delay1.31.45.6-0.40.71.01.01.61.6-0.80.72.4-0.50.50.8-0.81.7
Delay disc. indifference point, 16s delay1.01.02.3-0.61.00.91.21.31.3-1.50.90.0-0.80.8-0.90.41.2
Delay disc. indifference point, 2s delay0.20.20.5-0.20.40.40.50.60.6-0.60.70.5-0.30.3-0.1-0.50.4
Delay disc. indifference point, 24s delay0.30.31.3-0.40.20.30.20.10.10.4-0.51.10.5-0.50.70.40.5
Delay disc. indifference point, 4s delay0.70.73.5-0.20.40.50.61.01.1-0.50.11.9-0.20.21.0-0.51.2
Delay disc. indifference point, 8s delay0.40.42.2-0.00.10.30.30.80.8-0.1-0.41.5-0.10.10.9-0.20.9
Indifference point function ln k5.17.114.6-3.63.63.83.62.72.6-2.02.43.32.1-2.2-0.70.61.0
Indifference point function log k5.17.114.6-3.63.63.83.62.72.6-2.02.43.32.1-2.2-0.70.61.0
Patch foraging total patch changes 0 sec0.00.10.3-0.20.10.30.1-0.0-0.00.1-0.40.20.5-0.50.00.10.0
Patch foraging total patch changes 12 sec2.63.47.92.8-2.7-2.5-2.6-1.6-1.51.4-1.8-1.5-1.51.51.3-0.80.2
Patch foraging total patch changes 18 sec0.40.51.31.1-0.9-0.9-0.8-0.2-0.20.1-0.3-1.0-1.21.10.0-0.70.5
Patch foraging total patch changes 24 sec1.62.04.31.6-1.9-1.8-2.1-1.8-1.71.7-1.6-1.20.00.10.9-0.6-0.3
Patch foraging total patch changes 6 sec0.60.92.01.4-1.4-1.4-1.2-0.5-0.50.5-1.0-0.1-0.50.51.1-1.10.3
Patch foraging time to switch 0 sec1.92.910.22.4-1.6-2.1-1.10.20.3-0.70.7-0.7-3.23.10.5-1.91.1
Patch foraging water rate 0 sec2.84.511.4-3.32.62.82.10.30.3-0.20.10.63.4-3.4-1.72.2-1.3
Patch foraging water rate 12 sec5.27.920.5-4.53.73.93.11.21.1-0.20.52.64.1-4.1-1.02.6-1.1
Patch foraging water rate 18 sec2.02.76.2-2.52.12.11.91.11.1-0.50.82.02.4-2.4-0.20.6-0.3
Patch foraging water rate 24 sec2.63.69.4-3.12.62.72.10.70.7-0.30.71.52.7-2.8-1.01.5-0.9
Patch foraging water rate 6 sec2.63.810.4-3.02.32.31.90.60.60.10.32.33.2-3.2-0.11.6-0.8
Seeking ratio, delayed vs. immediate footshock0.30.41.00.30.10.20.40.80.8-1.00.70.6-0.60.60.4-0.80.8
Distance traveled before self-admin0.40.41.50.9-0.7-0.5-0.7-0.6-0.60.2-0.2-1.2-0.80.8-0.40.2-0.3
Distance traveled after self-admin0.30.42.50.5-0.5-0.3-0.5-0.5-0.50.3-0.6-1.6-0.40.4-0.40.6-0.4
Extensor digitorum longus weight4.015.936.06.0-5.9-5.9-5.5-3.6-3.53.0-2.8-2.1-2.72.83.6-3.50.3
Bone: elastic displacement1.41.66.7-1.60.90.80.6-0.3-0.30.8-0.71.02.6-2.60.41.1-0.6
Bone: elastic work1.21.52.90.6-1.1-1.1-1.2-1.3-1.31.6-1.70.31.6-1.61.7-0.4-0.2
Bone: endosteal estimation1.32.87.2-0.71.41.51.72.12.1-2.32.70.7-1.21.3-1.0-2.11.1
Bone: endosteal perimeter1.63.28.0-0.81.61.61.92.22.2-2.52.8-0.4-1.41.4-1.9-2.00.6
Epididymis fat weight1.74.07.8-2.42.82.82.82.32.3-2.42.21.00.3-0.3-2.00.00.7
Delta time in closed arm before/after self-admin0.60.63.40.0-0.3-0.2-0.2-0.1-0.00.9-0.51.60.8-0.81.80.10.6
Delta time in open arm before/after self-admin0.60.63.20.1-0.1-0.2-0.2-0.5-0.6-0.2-0.5-1.8-0.30.3-1.50.8-0.6
Diff in mean of infusions in LGA sessions0.50.61.60.5-0.7-0.8-0.9-1.0-1.00.8-0.9-1.30.3-0.3-0.20.4-0.5
Delay discount exponential model param0.40.41.4-0.1-0.2-0.3-0.4-0.9-0.90.5-0.0-1.10.7-0.7-0.50.4-1.2
Extinction: sum of active levers before priming2.92.97.12.7-2.3-2.4-2.0-1.0-1.00.7-1.0-1.5-2.12.11.0-1.60.0
Active lever presses in extinction session 62.22.24.41.3-1.6-1.6-1.9-2.1-2.11.7-1.1-2.0-0.10.1-0.10.2-1.8
Bone: final force1.62.55.72.4-2.3-2.3-2.1-1.4-1.40.9-0.9-1.4-1.11.20.9-2.0-0.2
Bone: final moment1.42.25.02.2-2.1-2.2-2.0-1.3-1.30.9-0.9-1.3-1.01.10.9-1.9-0.1
Food consumed during 24 hour testing period0.40.51.8-0.1-0.1-0.2-0.4-0.9-0.90.3-0.6-1.30.6-0.5-0.80.7-1.0
Glucose1.82.75.8-1.21.81.72.12.42.4-2.32.01.2-0.50.5-0.9-1.10.7
Heart weight2.13.05.9-2.22.42.02.42.12.1-1.81.61.90.7-0.8-0.80.11.1
Delay discount hyperbolic model param0.40.41.3-0.1-0.1-0.2-0.4-0.8-0.80.5-0.0-1.10.6-0.6-0.50.4-1.1
Intermittent access intake day 1-15 change1.00.92.7-1.10.80.60.5-0.4-0.5-0.10.2-1.31.0-1.0-1.61.4-1.4
Intermittent access intake escalation0.60.62.1-0.90.80.50.6-0.1-0.1-0.40.5-1.10.7-0.7-1.51.0-1.0
Intermittent access intake escalation 20.80.82.3-0.70.40.30.1-0.7-0.70.2-0.2-1.50.8-0.8-1.41.2-1.3
Intermitt. access day 1 inactive lever presses1.41.53.2-1.61.81.31.71.21.2-1.60.8-0.20.4-0.4-1.71.30.0
Intermitt. access day 15 inactive lever presses1.61.85.0-1.71.81.21.70.90.9-1.51.4-1.10.5-0.5-2.21.2-0.4
Intermitt. access escalation Index3.33.06.3-1.51.92.12.12.32.2-1.81.82.50.1-0.1-0.1-0.41.9
Intermittent access day 1 total infusions5.15.911.7-1.92.82.43.13.43.4-3.43.31.7-0.80.8-1.5-0.51.7
Intermittent access day 15 total infusions5.15.711.2-2.93.32.83.32.62.5-2.93.00.30.6-0.6-2.91.10.2
Intermittent access terminal intake (last 3 days)3.94.38.4-2.32.82.32.82.32.3-2.72.90.10.0-0.0-2.70.70.2
Intermittent access total infusions3.74.28.7-1.82.52.02.72.72.7-3.02.90.7-0.50.5-2.00.20.8
Intermittent access day 1 locomotion4.24.49.4-1.42.11.72.63.13.1-2.92.72.3-0.80.8-0.3-0.92.1
Intermittent access day 15 total locomotion3.23.46.6-2.22.62.22.62.12.1-2.42.20.10.2-0.2-2.30.80.3
Intermittent access total locomotion5.36.113.2-2.13.02.53.33.33.3-3.63.30.8-0.80.8-2.3-0.21.2
Intermittent access standard deviation0.90.92.6-1.41.20.91.00.30.3-0.60.3-0.40.9-0.9-1.51.6-0.7
Left kidney weight0.41.13.3-1.31.51.31.40.70.7-1.31.0-0.70.3-0.3-1.80.0-0.2
Right kidney weight0.30.84.7-0.70.70.40.4-0.5-0.5-0.50.3-2.00.4-0.4-2.20.4-0.4
Cocaine induced anxiety0.10.20.8-0.10.0-0.2-0.1-0.3-0.30.10.6-0.70.1-0.1-0.70.0-0.9
Post-drug Anxiety1.31.53.51.0-1.2-1.4-1.4-1.7-1.71.2-0.1-1.90.0-0.0-0.4-0.7-1.8
Baseline Anxiety1.71.83.51.5-1.8-1.6-1.9-1.7-1.71.6-1.5-1.1-0.10.11.0-0.6-0.5
Tail length1.03.17.50.6-1.5-1.4-1.9-2.4-2.42.7-2.5-0.51.7-1.81.21.3-1.1
Length with tail1.65.810.92.3-3.0-3.3-3.3-3.3-3.23.0-2.8-1.50.6-0.61.7-0.3-0.8
Length without tail1.63.58.12.3-2.6-2.8-2.7-2.2-2.21.8-1.6-1.3-0.30.41.4-1.3-0.2
Times rat made contact with spout0.30.31.30.8-0.8-0.8-0.7-0.1-0.10.4-0.80.2-0.40.41.2-0.00.3
Lifetime Intake3.53.98.3-1.72.31.92.62.72.7-2.92.81.2-0.60.6-1.5-0.11.2
Liver weight, left0.00.10.3-0.20.30.40.30.20.2-0.20.10.10.10.0-0.3-0.2-0.6
Liver weight, right0.20.31.3-0.30.20.40.20.20.20.20.11.10.6-0.60.6-1.20.2
Locomotor activity1.32.16.7-2.21.61.51.30.30.30.2-0.41.62.6-2.60.11.60.1
Locomotor testing distance1.93.29.8-2.61.91.91.50.50.50.3-0.42.43.1-3.10.61.70.3
Locomotor testing rearing1.62.45.6-2.31.81.91.61.11.1-0.1-0.42.12.3-2.40.41.20.4
Locomotion in novel chamber2.93.67.7-2.52.72.52.51.51.5-2.02.3-0.10.8-0.8-2.81.3-0.4
Locomotion in novel chamber post-restriction1.82.14.3-2.02.12.02.01.31.3-1.51.40.60.6-0.6-1.71.30.5
Fecal boli incidents, locomotor time 10.60.63.20.2-0.0-0.1-0.1-0.3-0.4-0.50.6-1.8-0.80.8-1.6-0.2-0.8
Change in fecal boli incidents, locomotor task0.70.63.00.2-0.20.10.00.60.60.20.41.70.2-0.21.7-0.91.0
Time >=10cm from walls, locomotor time 12.12.16.8-0.31.00.81.31.61.6-2.42.6-0.2-1.51.5-1.4-0.91.0
Bouts of movement, locomotor time 11.21.34.11.2-1.3-1.2-1.4-1.2-1.21.1-2.0-1.5-0.50.50.00.5-0.7
Total resting periods, locomotor time 10.80.92.31.1-1.1-1.1-1.1-0.9-0.90.6-1.5-1.5-0.70.7-0.30.3-0.6
Rest time, locomotor task time 10.70.82.1-1.51.31.41.00.30.2-0.10.30.11.1-1.1-1.10.9-0.2
Distance moved, locomotor task time 10.40.51.00.7-0.3-0.5-0.00.60.7-0.60.90.2-1.01.00.7-1.00.6
Vertical activity count, locomotor time 10.70.71.5-1.21.21.11.20.90.9-0.80.90.60.6-0.6-0.40.20.2
Time >=10cm from walls, locomotor time 20.20.20.70.3-0.0-0.0-0.00.00.0-0.40.1-0.6-0.70.7-0.90.1-0.2
Bouts of movement, locomotor time 20.40.41.10.8-0.8-0.8-0.7-0.5-0.50.2-1.0-0.6-0.60.60.30.1-0.2
Total resting periods, locomotor time 20.20.20.60.7-0.5-0.5-0.4-0.2-0.2-0.1-0.7-0.5-0.70.70.10.10.0
Rest time, locomotor task time 21.41.63.4-1.71.81.91.81.41.4-1.20.90.90.4-0.4-1.10.90.7
Distance moved, locomotor task time 20.80.91.71.1-1.3-1.3-1.3-1.1-1.11.1-0.8-0.7-0.20.20.9-0.5-0.8
Vertical activity count, locomotor time 20.90.93.2-0.5-0.1-0.1-0.4-1.0-1.01.4-0.80.41.8-1.80.80.4-0.8
Light reinforcement 10.10.31.3-0.70.50.90.30.10.10.3-0.40.10.4-0.5-0.11.2-0.2
Light reinforcement 20.81.15.2-1.21.31.11.00.30.2-0.71.1-1.3-0.30.2-2.30.5-0.7
Bone: marrow area1.43.07.7-0.71.41.61.82.22.2-2.32.80.8-1.21.3-1.0-2.21.2
Bone: maximum diameter0.30.63.20.4-0.4-0.5-0.5-0.7-0.70.00.2-1.8-0.60.6-1.1-1.0-0.7
Bone: maximum force2.13.79.03.0-2.5-2.6-2.1-0.8-0.70.0-0.0-1.8-2.42.40.8-2.90.4
Bone: maximum moment1.83.28.02.8-2.3-2.4-1.9-0.7-0.60.0-0.0-1.6-2.22.20.7-2.80.4
Mean time between licks in bursts0.81.14.10.6-1.0-0.6-1.0-0.7-0.71.3-1.21.31.0-1.02.0-0.30.2
Mean num. licks in bursts0.20.20.8-0.50.40.50.50.60.60.2-0.20.90.5-0.40.40.10.2
Cd content in liver1.01.13.7-1.51.41.41.00.10.1-0.40.4-0.90.5-0.6-1.91.6-1.0
Co content in liver1.51.85.7-1.81.21.30.90.10.10.6-1.01.52.0-2.00.32.4-0.5
Cu content in liver0.20.20.80.8-0.6-0.9-0.4-0.0-0.0-0.2-0.4-0.5-0.60.60.3-0.20.3
Fe content in liver0.10.20.50.3-0.4-0.3-0.5-0.6-0.60.40.1-0.70.2-0.2-0.1-0.6-0.3
K content in liver1.51.55.41.8-1.4-1.6-1.00.10.1-0.20.10.0-1.51.51.1-2.30.8
Mg content in liver1.41.43.11.0-0.3-0.50.21.41.4-1.31.20.6-1.61.70.6-1.81.2
Mn content in liver1.51.74.01.8-1.8-2.0-1.8-1.3-1.30.8-0.5-1.8-0.80.80.1-0.8-0.4
Na content in liver0.91.02.41.0-1.1-1.2-1.2-1.4-1.41.0-1.1-1.6-0.10.1-0.1-0.3-0.5
Rb content in liver1.21.53.8-1.01.41.51.62.02.0-1.61.01.3-0.20.2-0.2-0.10.7
Se content in liver0.40.52.40.20.1-0.30.10.20.2-0.70.9-1.5-0.80.8-1.3-0.4-0.3
Sr content in liver2.72.44.81.3-1.8-1.4-2.0-2.2-2.21.9-2.1-1.70.3-0.30.30.7-1.4
Zn content in liver0.60.72.11.4-1.2-1.4-1.0-0.5-0.50.3-0.6-0.4-0.80.80.7-0.50.1
Bone: minimum diameter1.52.86.3-0.31.21.21.72.42.4-2.52.20.4-1.71.7-0.8-1.81.1
Time in familiar zone, hab. session 10.50.41.7-0.20.50.60.60.80.8-1.01.30.3-0.40.5-0.2-0.50.5
Time in novel zone, hab. session 10.70.72.2-0.80.40.30.2-0.3-0.30.9-1.20.91.4-1.50.50.7-0.2
Total zone transitions, hab. session 10.40.51.51.2-1.1-1.2-0.9-0.4-0.40.2-0.1-0.2-0.80.70.7-0.30.5
Total locomotion distance, hab. session 10.50.71.1-0.30.70.80.91.01.0-1.01.00.6-0.80.7-0.3-0.90.8
Locomotion velocity, hab. session 10.20.30.80.20.20.20.40.60.6-0.70.60.3-0.90.8-0.0-0.90.6
Time in familiar zone, hab. session 20.70.72.5-0.4-0.10.2-0.2-0.3-0.30.9-0.91.11.6-1.51.2-0.3-0.1
Time in novel zone, hab. session 20.40.42.00.6-0.2-0.30.00.40.4-0.60.7-0.4-1.41.3-0.40.10.4
Total zone transitions, hab. session 21.52.04.92.0-1.4-1.2-0.80.80.8-0.40.70.6-2.02.01.6-2.21.5
Total locomotion distance, hab. session 21.11.53.70.50.10.20.51.51.5-1.11.41.3-1.51.50.7-1.91.4
Locomotion velocity, hab. session 21.21.63.70.40.30.30.71.61.6-1.41.71.0-1.61.60.3-1.91.3
Novel to familiar place preference ratio0.90.93.01.3-1.0-1.0-0.9-0.5-0.5-0.10.3-1.7-1.41.4-0.8-0.1-0.1
Novelty place preference0.60.62.10.9-0.6-0.6-0.5-0.2-0.2-0.30.3-1.5-1.31.3-0.90.20.0
Time in novel zone, NPP test0.40.41.40.8-0.5-0.4-0.4-0.1-0.1-0.20.3-1.2-1.01.0-0.70.20.1
Total zone transitions, NPP test1.21.74.82.2-1.9-1.8-1.6-0.5-0.50.6-0.5-0.4-1.41.51.2-1.30.8
Total locomotion distance, NPP test0.40.51.20.6-0.2-0.20.10.70.7-0.50.50.6-1.11.10.5-1.00.9
Locomotion velocity, NPP test0.30.51.50.7-0.3-0.30.00.50.6-0.50.50.3-1.21.20.4-0.80.9
Intraocular pressure1.01.45.7-1.51.21.10.8-0.3-0.4-0.20.1-1.70.9-0.8-2.41.7-0.8
Delta distance traveled before/after self-admin0.10.10.4-0.30.10.10.0-0.1-0.10.4-0.5-0.10.6-0.60.40.40.1
Delta ambulatory time before/after self-admin0.20.20.6-0.2-0.10.1-0.1-0.2-0.20.7-0.70.10.7-0.70.70.40.1
Parametrial fat weight2.24.39.5-1.62.42.52.72.82.8-3.12.90.8-0.60.7-1.7-0.50.8
Pavlov. Cond. lever latency0.20.20.8-0.80.50.30.4-0.0-0.00.2-0.60.10.3-0.3-0.20.9-0.6
Pavlov. Cond. magazine entry latency0.40.51.30.8-0.3-0.10.00.70.7-0.80.9-0.3-1.11.1-0.1-0.60.9
Pavlov. Cond. change in total contacts0.40.51.70.5-0.1-0.10.10.30.3-0.90.9-1.3-0.70.7-1.10.10.5
Pavlov. Cond. index score0.10.10.50.5-0.3-0.2-0.2-0.1-0.1-0.20.4-0.7-0.00.1-0.4-0.00.3
Pavlov. Cond. latency score0.10.10.40.4-0.20.0-0.00.20.2-0.30.7-0.3-0.10.1-0.2-0.30.5
Pavlov. Cond. lever contacts0.10.10.30.2-0.10.10.10.20.2-0.20.50.20.2-0.10.1-0.40.5
Pavlov. Cond. magazine entry number0.30.32.0-0.50.40.40.50.50.5-0.10.11.4-0.0-0.00.8-0.60.2
Pavlov. Cond. intertrial magazine entries0.40.51.4-0.80.70.50.5-0.1-0.1-0.30.0-0.50.9-0.8-1.11.2-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.60.8-0.5-0.4-0.4-0.2-0.2-0.10.3-0.8-0.30.3-0.2-0.30.3
Pavlov. Cond. response bias0.10.10.70.4-0.2-0.2-0.2-0.2-0.2-0.10.1-0.80.2-0.2-0.60.40.0
Pavlov. Cond. lever latency0.50.62.1-0.90.80.90.80.60.6-0.1-0.11.41.0-1.00.40.80.5
Pavlov. Cond. magazine entry latency2.12.46.02.5-2.2-2.3-2.0-1.0-0.90.7-1.2-1.1-1.81.81.2-0.90.3
Pavlov. Cond. change in total contacts1.72.37.12.0-1.6-1.8-1.4-0.8-0.8-0.1-0.1-2.7-2.42.4-0.7-0.6-0.5
Pavlov. Cond. index score1.62.14.62.1-1.8-2.0-1.7-1.0-1.00.3-0.5-2.0-1.91.90.1-1.0-0.3
Pavlov. Cond. latency score1.41.83.81.9-1.6-1.8-1.5-0.9-0.80.1-0.3-1.8-1.81.80.0-1.1-0.2
Pavlov. Cond. lever contacts0.50.72.70.7-0.8-0.9-1.0-1.0-1.00.6-0.5-1.6-0.60.5-0.5-0.3-0.9
Pavlov. Cond. magazine entry number3.64.410.6-3.33.03.12.81.61.6-1.11.41.92.2-2.2-1.11.0-0.1
Pavlov. Cond. intertrial magazine entries0.60.82.0-1.41.41.31.30.80.8-0.70.90.40.5-0.6-1.00.30.0
Pavlov. Cond. lever-magazine prob. diff.1.92.45.42.3-2.0-2.2-1.9-1.1-1.10.4-0.7-2.0-2.01.90.3-1.1-0.2
Pavlov. Cond. response bias1.21.73.41.7-1.6-1.7-1.6-1.2-1.20.7-0.9-1.8-1.41.40.0-0.6-0.5
Time in closed arm before self-admin0.20.20.70.3-0.10.1-0.00.00.0-0.60.4-0.7-0.70.7-0.8-0.2-0.1
Time in closed arm after self-admin0.20.20.5-0.00.10.20.20.40.4-0.30.70.70.0-0.00.7-0.10.7
Time in open arm before self-admin1.01.16.1-0.80.60.60.70.80.80.4-0.02.51.0-1.01.7-0.40.8
Time in open arm after self-admin0.30.30.9-0.70.40.30.2-0.2-0.20.4-0.90.10.9-0.9-0.30.7-0.3
Bone: periosteal estimation0.30.73.20.20.20.10.30.50.5-1.11.3-0.8-1.01.0-0.9-1.80.1
Bone: periosteal perimeter0.30.52.10.6-0.3-0.4-0.20.10.1-0.60.6-1.2-0.80.9-0.6-1.4-0.1
Bone: post-yield work4.76.420.32.0-0.5-0.50.42.22.2-3.13.2-1.1-4.54.5-1.0-3.41.5
Progressive ratio test 1 active lever presses1.71.73.7-1.81.91.51.91.51.4-1.40.90.60.6-0.6-1.41.20.2
Progressive ratio test 1 breakpoint1.51.53.3-1.81.81.41.71.21.2-1.10.80.50.7-0.7-1.31.30.1
Progressive ratio test 1 inactive lever presses0.90.91.7-1.11.31.01.31.21.2-1.20.40.90.3-0.3-0.41.20.7
Progressive ratio test 2 active lever presses2.72.95.7-2.12.41.92.31.71.7-2.01.9-0.10.5-0.5-2.31.10.0
Progressive ratio test 2 breakpoint3.03.47.3-2.62.72.32.51.61.6-1.81.80.11.1-1.1-2.41.5-0.1
Progressive ratio test 2 inactive lever presses5.76.612.6-3.13.63.23.52.82.8-3.13.10.40.5-0.5-3.11.60.4
Incentive Sensitization - Responses0.40.41.2-0.50.70.50.70.60.6-1.01.0-0.7-0.20.2-1.10.1-0.1
Incentive Sensitization - Breakpoint0.50.61.6-0.70.90.70.90.70.7-1.11.0-0.7-0.10.1-1.20.2-0.1
Sum of active levers in priming session hrs 5-63.23.111.40.8-1.2-1.5-1.7-2.4-2.51.6-1.1-3.40.3-0.3-1.51.2-2.3
Progressive ratio2.02.36.82.3-1.5-1.4-1.00.40.5-0.60.90.1-2.62.60.9-2.20.9
Food seeking constrained by brief footshock0.30.31.60.4-0.6-0.4-0.6-0.5-0.40.7-0.40.50.5-0.51.30.1-0.1
Seeking ratio, punishment vs. effort1.61.96.8-2.01.41.41.0-0.1-0.10.6-0.81.02.6-2.60.21.6-0.4
Retroperitoneal fat weight3.311.021.6-4.04.64.54.63.83.7-4.03.82.00.9-0.8-3.10.80.4
Reaction time number correct0.40.61.40.3-0.7-0.6-0.9-1.2-1.21.1-1.0-0.40.6-0.60.4-0.5-0.1
Reaction time mean minus median2.02.65.62.3-2.1-2.4-2.0-1.4-1.40.5-0.0-2.1-2.12.0-0.1-0.9-0.3
Reaction time mean minus median AUC1.11.53.51.5-1.5-1.9-1.6-1.5-1.50.7-0.3-1.6-1.11.0-0.1-0.3-0.6
Reaction time num false alarms0.50.75.0-0.70.40.60.40.10.10.2-0.12.21.0-1.01.30.10.5
Reaction time num false alarms AUC0.40.63.80.0-0.3-0.2-0.3-0.3-0.30.6-0.42.00.5-0.61.6-0.10.7
Reaction time trials correct on left0.40.61.40.3-0.7-0.6-0.9-1.2-1.21.1-1.0-0.40.6-0.60.4-0.5-0.1
Reaction time trials on left0.50.71.70.4-0.8-0.7-1.0-1.3-1.31.2-1.1-0.40.6-0.70.4-0.5-0.1
Reaction time mean0.20.31.00.3-0.1-0.3-0.1-0.2-0.2-0.40.4-0.8-0.90.7-1.00.3-0.3
Reaction time mean AUC0.30.41.20.3-0.0-0.20.0-0.0-0.0-0.70.6-0.9-1.10.9-1.10.1-0.2
Median of all reaction times0.20.21.1-0.10.40.20.40.30.3-0.70.5-0.4-0.70.6-1.00.4-0.2
Reaction time omissions0.81.13.01.5-1.4-1.7-1.3-1.1-1.00.6-0.6-0.7-0.90.90.6-0.70.0
Reaction time false alarm rate0.40.54.1-0.50.30.40.50.40.4-0.10.32.00.5-0.51.10.20.6
Reaction time premature initiation rate2.02.66.31.5-2.0-1.8-2.0-1.6-1.62.3-2.30.80.2-0.22.5-0.60.3
Reaction time premature initiations3.24.59.31.9-2.6-2.4-2.8-2.5-2.53.1-3.00.20.5-0.52.7-0.60.2
Std. dev. reaction times0.60.92.21.2-1.0-1.3-1.0-0.9-0.90.10.2-1.5-1.31.2-0.5-0.2-0.4
Reaction time trials completed0.50.71.70.4-0.8-0.7-1.0-1.3-1.31.2-1.1-0.40.6-0.70.4-0.5-0.1
Reaction time trials AUC0.30.51.10.3-0.6-0.5-0.8-1.0-1.01.0-0.9-0.20.6-0.70.5-0.5-0.0
Run reversals in cocaine runway, females1.81.84.41.2-0.7-0.7-0.21.01.0-0.70.82.0-1.41.42.1-1.72.1
Run reversals in cocaine runway, males1.11.03.2-1.00.50.40.1-1.0-1.01.0-0.8-0.21.8-1.8-0.31.4-1.1
Latency to leave start box in cocaine runway0.60.61.50.30.10.10.40.90.9-1.21.10.1-1.11.1-0.2-0.70.9
Latency to leave start box in cocaine runway, F0.30.30.90.4-0.0-0.00.20.60.6-0.80.30.1-1.01.0-0.1-0.30.6
Latency to leave start box in cocaine runway, M0.10.10.80.10.0-0.10.10.10.1-0.40.9-0.2-0.20.2-0.1-0.20.2
Std. dev. time between licks in bursts0.60.82.9-0.50.10.4-0.0-0.3-0.20.8-0.61.71.5-1.51.30.30.0
Total sessions with >9 infusions1.61.83.6-1.11.51.21.71.91.9-1.81.71.6-0.20.2-0.2-0.31.3
Short access day 1 total inactive lever presses2.52.85.4-2.02.22.32.32.02.0-2.01.80.90.5-0.5-1.20.51.2
Short access day 10 total inactive lever presses2.12.34.6-2.12.11.82.11.51.5-1.41.01.51.2-1.2-0.51.31.1
Short access day 1 total infusions3.43.67.3-1.21.91.92.32.72.7-2.62.51.7-0.80.8-0.8-0.42.0
Short access day 10 total infusions3.33.78.3-0.41.31.01.82.82.8-2.92.81.4-1.71.7-0.4-1.51.9
Short access total infusions2.12.45.1-0.71.31.11.72.22.2-2.12.21.7-0.90.9-0.2-0.91.7
Short access day 1 locomotion2.62.86.0-1.21.71.32.02.42.4-2.32.41.7-0.50.5-0.3-0.41.6
Short access day 10 total locomotion2.02.25.0-0.81.41.21.82.22.2-2.21.81.5-0.80.8-0.0-0.81.4
Short access total locomotion2.02.14.6-0.71.21.01.62.12.1-2.01.71.8-0.70.70.1-0.81.5
One hour access (0.3 mA shock)5.86.814.6-3.63.83.23.62.62.5-2.72.61.21.4-1.4-2.81.90.2
Compulsive drug intake2.52.56.71.4-1.9-1.6-1.9-1.6-1.62.2-2.60.50.4-0.42.40.10.1
One hour access (shock baseline)5.86.714.6-3.33.73.13.52.42.3-3.03.0-0.30.8-0.8-3.81.6-0.4
Social response proportion0.50.61.41.1-1.0-1.2-1.0-0.6-0.60.5-0.4-0.8-0.70.70.2-0.20.3
Social responses0.30.40.70.3-0.6-0.7-0.7-0.7-0.70.8-0.8-0.20.5-0.60.40.4-0.6
Social time0.50.61.60.4-0.7-0.8-0.9-0.9-0.91.3-1.10.10.6-0.70.80.2-0.7
Soleus weight2.26.514.2-3.63.83.83.62.42.4-2.32.51.51.6-1.6-2.11.00.2
Bone: stiffness1.82.86.92.6-2.0-2.1-1.7-0.5-0.5-0.20.0-1.8-2.52.40.3-2.10.2
Tibialis anterior weight6.321.744.26.0-6.5-6.6-6.6-5.6-5.54.8-4.1-3.5-1.51.53.1-2.9-1.2
Time to tail flick, vehicle, before self-admin0.60.62.80.9-0.7-0.7-0.50.10.1-0.31.00.2-1.11.10.3-1.70.3
Time to tail flick, vehicle, after self-admin1.11.13.21.5-1.3-1.2-0.90.00.10.2-0.01.1-1.11.11.8-1.50.8
Time to tail flick, test, before self-admin1.91.95.4-0.30.80.71.21.81.8-1.41.92.3-0.70.70.7-1.41.6
Time to tail flick, test, after self-admin0.10.10.1-0.1-0.1-0.2-0.2-0.3-0.30.4-0.10.00.3-0.30.0-0.0-0.3
Delta time to tail flick, vehicle, before/after SA0.40.41.50.8-0.7-0.7-0.50.00.00.3-0.70.5-0.50.51.2-0.30.5
Delta time to tail flick, test, before/after SA2.92.65.30.4-1.1-1.0-1.6-2.3-2.32.1-2.2-1.91.1-1.1-0.31.3-2.1
Tibia length1.13.012.51.6-1.7-1.9-2.0-2.3-2.31.1-0.7-3.5-0.60.7-1.2-0.2-1.6
Ambulatory time before self-admin0.60.63.10.7-0.6-0.6-0.6-0.6-0.6-0.20.0-1.8-0.90.9-1.10.1-0.7
Ambulatory time after self-admin0.50.52.40.10.30.40.40.50.4-0.90.5-1.6-0.80.8-1.20.60.2
Bone: tissue strength0.20.20.70.3-0.1-0.3-0.10.00.0-0.30.7-0.8-0.80.7-0.4-0.3-0.3
Total heroin consumption3.23.87.92.8-2.8-2.5-2.7-1.9-1.91.7-1.8-1.5-1.41.41.4-1.4-0.6
Bone: trabecular number0.61.03.01.3-0.7-1.0-0.40.50.5-0.80.4-0.9-1.71.7-0.2-1.50.2
Bone: trabecular spacing0.20.31.2-0.70.50.50.40.20.20.2-0.21.10.6-0.60.60.70.4
Bone: trabecular thickness0.60.72.1-0.30.80.71.01.41.4-1.40.80.1-0.60.5-0.5-0.30.4
Bone: trabecular tissue density1.92.66.1-2.52.42.42.21.11.0-1.41.40.11.1-1.1-1.81.5-0.2
Water consumed over 24 hours0.60.72.00.8-1.0-1.1-1.1-0.8-0.81.1-1.4-0.40.3-0.20.80.7-0.2
Number of responses in last shaping day0.90.92.0-1.41.21.11.10.60.6-0.20.41.21.2-1.2-0.31.20.3