Hub : Genes

Kcnj6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr11_34276411_34308566 0.04 0.03 1.9e-03 0.01 0.01 0.01 0.01 1.8e-02 2.4e-02 4.0e-02 2.3e-02
2 PL gene expression Kcnj6 0.03 0.02 1.0e-03 0.04 0.03 0.03 0.03 9.8e-05 8.6e-04 4.1e-04 4.2e-04
3 Brain isoform ratio NM_001393803.1 0.58 0.12 0.0e+00 0.29 0.37 0.4 0.39 6.0e-27 2.7e-36 1.4e-39 2.1e-38
4 Brain isoform ratio NM_013192.3 0.56 0.12 0.0e+00 0.28 0.37 0.39 0.38 1.5e-26 7.6e-36 8.7e-39 1.1e-37
5 Brain intron excision ratio chr11_34250394_34308566 0.07 0.04 1.4e-04 0.02 0.03 0.03 0.03 2.7e-03 1.7e-03 2.0e-03 1.9e-03
6 OFC intron excision ratio chr11_34276411_34308566 0.15 0.09 4.8e-03 0.08 0.1 0.07 0.08 6.6e-03 2.1e-03 7.7e-03 4.9e-03
7 pVTA isoform ratio NM_013192.3 0.14 0.07 6.1e-05 0.09 0.11 0.09 0.1 8.4e-05 2.4e-05 9.9e-05 3.6e-05
8 pVTA isoform ratio NM_001393803.1 0.14 0.07 2.0e-05 0.1 0.12 0.09 0.1 4.1e-05 1.0e-05 9.6e-05 4.5e-05
9 BLA mRNA stability Kcnj6 0.08 0.06 1.6e-03 0.03 0.03 0.03 0.04 7.5e-03 9.7e-03 8.5e-03 3.6e-03
10 OFC isoform ratio NM_001393803.1 0.23 0.12 3.9e-04 0.03 0.14 0.15 0.06 6.7e-02 2.9e-04 2.0e-04 1.3e-02
11 LHb isoform ratio NM_001393803.1 0.21 0.12 1.3e-03 0.14 0.14 0.09 0.09 4.4e-04 3.8e-04 3.2e-03 3.7e-03
12 OFC isoform ratio NM_013192.3 0.19 0.11 1.9e-03 0.03 0.11 0.09 0.01 7.7e-02 1.7e-03 3.6e-03 1.6e-01
13 Brain gene expression Kcnj6 0.13 0.07 6.0e-04 0.04 0.04 0.03 0.03 2.9e-04 4.7e-05 3.8e-04 7.6e-04
14 PL mRNA stability Kcnj6 0.17 0.11 6.2e-08 0.08 0.03 0.06 0.08 3.5e-09 1.3e-04 4.3e-07 8.4e-09
15 LHb isoform ratio NM_013192.3 0.15 0.1 7.4e-03 0.1 0.08 0.05 0.05 2.7e-03 5.4e-03 2.2e-02 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.10.6-0.10.10.2-0.2-0.1-0.20.4-0.40.10.2-0.40.2-0.8-0.00.1
Area under the delay curve1.31.43.8-0.50.31.1-1.0-1.20.70.4-0.4-0.82.0-1.51.9-1.60.6-1.5
BMI with tail0.41.23.31.0-0.91.8-1.80.2-0.61.3-1.3-0.11.0-1.61.0-0.40.4-1.0
BMI without tail0.10.21.1-0.00.10.4-0.3-0.40.30.0-0.0-0.80.7-0.40.6-0.31.0-0.4
Body weight0.10.61.90.9-0.81.4-1.40.4-0.61.0-1.00.30.5-1.00.5-0.1-0.1-0.4
Weight adjusted by age1.21.32.9-1.31.2-0.70.7-1.21.6-1.51.5-1.70.80.90.5-0.01.70.4
Bone surface2.13.86.12.5-2.52.4-2.42.2-2.22.2-2.22.2-0.4-1.2-0.21.8-2.1-0.5
Bone volume1.52.54.01.9-1.92.0-2.01.6-1.92.0-2.01.8-0.2-1.2-0.10.9-1.7-0.4
Breakpoint value in progressive ratio session0.50.52.5-0.20.4-0.50.50.20.5-0.80.8-0.1-0.41.3-0.41.30.01.6
Number of licking bursts0.50.61.5-0.60.7-0.20.3-0.90.6-0.10.1-1.11.0-0.50.9-1.21.2-0.9
Context. condit. distance diff. score0.20.20.5-0.50.4-0.10.1-0.40.5-0.60.60.2-0.10.6-0.3-0.5-0.50.7
Locomotion velocity, session 10.20.20.60.10.0-0.20.20.4-0.50.2-0.20.6-0.80.2-0.7-0.2-0.60.4
Locomotion distance, session 10.60.84.00.2-0.20.0-0.10.7-1.00.4-0.51.8-1.10.3-1.1-0.2-2.00.7
Locomotion velocity, session 20.40.41.70.00.1-0.40.30.5-0.2-0.30.31.0-0.80.7-0.70.8-1.30.7
Locomotion distance, session 20.10.21.3-0.40.4-0.10.1-0.2-0.10.2-0.20.80.2-0.30.3-0.5-1.1-0.2
Locomotion velocity, session 32.63.05.61.9-1.80.7-0.72.3-2.21.1-1.12.3-2.40.5-2.31.6-2.11.1
Locomotion distance, session 30.30.31.40.7-0.80.5-0.60.6-0.30.5-0.40.10.0-0.10.21.2-0.00.1
Stereotopy head waving bouts, day 30.70.82.70.9-0.9-0.30.21.2-1.40.7-0.80.2-1.60.0-1.60.20.50.1
Stereotopy head waving duration, day 30.70.92.51.0-1.0-0.0-0.11.3-1.50.8-0.90.5-1.5-0.1-1.60.00.2-0.1
Locomotion velocity, session 71.21.32.2-1.51.4-1.31.3-1.21.4-1.41.4-1.20.30.90.3-0.61.00.7
Locomotion distance, session 72.12.65.5-2.12.0-1.21.3-2.12.3-1.71.7-1.91.60.41.7-0.81.4-0.0
Stereotopy head waving bouts, day 72.12.46.91.5-1.40.0-0.12.1-1.90.6-0.71.7-2.60.9-2.61.4-1.21.3
Stereotopy head waving duration, day 72.53.07.41.6-1.60.3-0.42.2-1.90.7-0.72.2-2.71.1-2.71.5-2.01.6
Locomotion velocity, session 81.72.13.71.7-1.80.8-0.81.9-1.70.8-0.91.8-1.90.4-1.91.4-1.60.8
Locomotion distance, session 80.20.31.4-0.60.6-0.10.2-0.50.4-0.40.40.70.10.20.0-0.6-1.20.2
Degree of sensitization distance1.91.93.8-2.01.9-1.31.3-1.91.7-1.51.4-1.30.90.40.8-1.71.0-0.1
Degree of sensitization stereotypy2.42.75.01.8-1.80.9-0.92.2-1.91.0-1.12.2-2.00.5-2.01.6-2.01.0
Conditioned locomotion0.50.61.2-0.90.9-0.80.8-0.81.0-1.11.1-0.80.10.80.0-0.20.60.7
Cocaine response after cond. corrected0.60.72.0-0.50.4-0.90.90.10.1-0.70.71.0-1.11.1-1.00.1-1.40.8
Cocaine response after cond. not corrected0.80.91.6-0.90.9-1.21.2-0.30.6-1.11.10.7-0.71.2-0.70.2-1.30.8
Cocaine response before conditioning0.10.20.5-0.50.6-0.20.2-0.50.4-0.20.2-0.10.7-0.20.7-0.1-0.2-0.5
Saline control response0.71.03.10.7-0.70.3-0.31.0-0.80.2-0.21.3-1.31.0-1.50.7-1.31.8
Bone: connectivity density0.40.61.30.8-0.81.0-1.00.7-0.91.1-1.10.90.1-0.80.20.3-1.0-0.3
Bone: cortical apparent density0.30.40.90.2-0.20.5-0.50.3-0.80.9-1.00.90.1-0.80.1-0.8-0.9-0.6
Bone: cortical area0.20.31.10.1-0.1-0.20.20.40.0-0.40.50.6-0.60.9-0.61.1-0.90.7
Bone: cortical porosity0.20.31.8-0.70.7-0.40.4-0.60.2-0.20.2-0.20.1-0.1-0.0-1.30.2-0.2
Bone: cortical porosity0.30.41.8-0.80.8-0.30.4-0.90.5-0.30.2-0.30.5-0.20.4-1.30.3-0.6
Bone: cortical thickness1.42.34.6-1.81.8-2.02.1-1.21.6-2.12.1-0.6-0.41.9-0.5-0.10.21.2
Bone: cortical thickness0.30.30.7-0.70.7-0.50.5-0.70.9-0.70.8-0.60.50.50.4-0.10.50.3
Bone: cortical tissue density0.40.51.20.3-0.30.6-0.60.3-0.91.0-1.10.90.1-0.90.1-0.8-0.9-0.6
Condit. Reinf. active minus inactive responses0.00.00.1-0.10.2-0.20.2-0.10.2-0.30.3-0.30.00.20.00.20.20.1
Condit. Reinf. active-inactive response ratio0.50.61.3-0.60.6-0.90.9-0.40.7-1.01.0-0.7-0.41.1-0.40.20.61.1
Condit. Reinf. active responses0.10.10.50.00.00.1-0.10.1-0.20.2-0.20.60.0-0.20.1-0.0-0.7-0.4
Condit. Reinf. inactive responses0.40.52.20.3-0.20.1-0.20.5-0.90.7-0.71.3-0.4-0.4-0.4-0.2-1.5-0.4
Incentive salience index mean0.10.20.4-0.40.4-0.30.3-0.50.6-0.50.5-0.50.40.20.40.20.4-0.2
Condit. Reinf. lever presses0.30.40.8-0.70.7-0.50.6-0.80.9-0.80.8-0.50.40.30.4-0.30.3-0.3
Condit. Reinf. active minus inactive responses0.30.42.10.4-0.50.8-0.80.3-0.50.6-0.61.2-0.1-0.4-0.1-0.1-1.4-0.1
Condit. Reinf. active-inactive response ratio0.70.71.90.1-0.11.1-1.0-0.60.20.5-0.5-0.21.4-1.31.3-0.90.2-1.4
Condit. Reinf. active responses0.81.12.70.8-0.80.2-0.21.2-1.00.3-0.41.6-1.60.7-1.50.8-1.61.3
Condit. Reinf. inactive responses1.62.05.90.6-0.6-0.60.61.5-1.0-0.10.11.5-2.41.6-2.31.3-1.52.3
Condit. Reinf. lever presses0.30.53.10.8-0.90.4-0.40.8-0.20.00.00.7-0.40.3-0.31.7-0.80.2
Condit. Reinf. lever reinforcers received0.81.12.80.9-0.90.4-0.41.2-1.00.4-0.41.6-1.40.6-1.30.9-1.71.1
Conditioned reinforcement - actives0.30.30.9-0.70.6-0.40.4-0.90.6-0.20.3-0.70.7-0.20.8-1.00.0-0.3
Conditioned reinforcement - inactives2.02.24.6-1.81.8-2.12.1-1.21.6-2.02.1-0.9-0.41.8-0.4-0.20.01.0
Conditioned locomotion0.20.30.6-0.70.6-0.70.7-0.30.5-0.60.6-0.2-0.20.7-0.2-0.10.00.8
Patch foraging indifference point 0 sec2.13.37.5-1.61.3-2.52.5-0.61.5-2.52.4-0.4-1.62.7-1.50.70.22.5
Patch foraging indifference point AUC1.72.04.01.0-1.00.2-0.31.6-1.30.3-0.32.0-2.01.2-2.01.5-2.01.9
Delay disc. indifference point, 0s delay0.80.92.30.2-0.41.5-1.4-0.2-0.41.0-1.10.31.2-1.51.1-1.0-0.3-1.1
Delay disc. indifference point, 16s delay0.70.71.5-0.10.20.7-0.7-0.70.30.4-0.4-0.91.2-1.21.2-1.10.9-1.2
Delay disc. indifference point, 2s delay0.91.02.40.2-0.41.3-1.3-0.4-0.10.9-0.90.01.4-1.61.4-0.9-0.1-1.5
Delay disc. indifference point, 24s delay1.41.33.4-1.11.00.1-0.1-1.51.1-0.30.3-1.01.7-1.11.7-1.50.7-1.8
Delay disc. indifference point, 4s delay0.80.82.1-0.0-0.41.1-1.0-0.60.10.8-0.7-0.21.3-1.41.4-1.10.1-1.2
Delay disc. indifference point, 8s delay1.01.13.0-0.80.80.4-0.3-1.41.1-0.30.4-1.11.7-0.81.5-1.30.8-1.1
Indifference point function ln k0.60.81.4-1.21.1-0.90.9-1.21.1-0.80.8-1.00.70.00.7-0.90.9-0.4
Indifference point function log k0.60.81.4-1.21.1-0.90.9-1.21.1-0.80.8-1.00.70.00.7-0.90.9-0.4
Patch foraging total patch changes 0 sec1.82.97.0-1.31.0-2.12.2-0.31.2-2.22.1-0.2-1.72.6-1.60.8-0.02.6
Patch foraging total patch changes 12 sec1.92.58.20.9-1.0-0.30.31.6-0.7-0.40.41.3-2.42.1-2.32.3-1.22.9
Patch foraging total patch changes 18 sec1.41.84.90.4-0.6-0.50.41.2-0.8-0.30.31.8-2.21.6-2.21.1-1.82.2
Patch foraging total patch changes 24 sec0.50.61.70.4-0.70.4-0.40.7-0.4-0.10.01.2-0.90.7-1.00.8-1.31.0
Patch foraging total patch changes 6 sec2.23.29.30.2-0.2-1.41.41.3-0.5-1.01.01.4-3.02.6-2.81.8-1.43.0
Patch foraging time to switch 0 sec0.60.93.3-0.0-0.00.3-0.3-0.4-0.20.9-0.9-0.71.1-1.71.3-1.20.9-1.8
Patch foraging water rate 0 sec1.42.34.71.4-1.50.5-0.52.0-1.30.3-0.31.7-2.11.2-2.02.2-1.52.0
Patch foraging water rate 12 sec1.52.24.5-1.81.8-1.71.8-1.51.8-2.12.1-1.0-0.11.6-0.3-0.90.81.1
Patch foraging water rate 18 sec0.30.41.70.9-0.81.3-1.20.4-0.30.6-0.5-0.10.5-0.50.40.60.2-0.2
Patch foraging water rate 24 sec0.40.51.7-0.70.7-0.10.2-0.91.3-1.11.1-0.60.70.70.60.30.10.5
Patch foraging water rate 6 sec0.10.20.5-0.40.3-0.20.3-0.60.7-0.60.6-0.30.30.20.3-0.10.2-0.3
Seeking ratio, delayed vs. immediate footshock0.40.51.3-0.10.10.2-0.3-0.3-0.40.8-0.8-0.40.7-1.10.8-1.20.7-0.9
Distance traveled before self-admin0.10.10.30.2-0.30.2-0.10.3-0.10.1-0.00.1-0.10.2-0.10.60.00.5
Distance traveled after self-admin0.50.62.20.4-0.51.0-1.0-0.20.30.4-0.3-1.01.5-0.81.30.50.0-0.4
Extensor digitorum longus weight3.312.923.04.6-4.73.9-4.04.2-4.84.5-4.63.6-1.6-2.6-1.41.8-2.8-1.2
Bone: elastic displacement0.20.31.2-0.50.6-0.30.3-0.60.4-0.30.2-0.80.3-0.10.1-1.10.90.0
Bone: elastic work0.00.10.30.0-0.0-0.00.10.0-0.2-0.1-0.0-0.2-0.30.1-0.5-0.50.40.1
Bone: endosteal estimation2.24.810.12.8-2.83.2-3.21.9-2.22.8-2.71.40.4-2.20.61.2-1.0-1.3
Bone: endosteal perimeter1.02.04.01.7-1.71.7-1.71.6-1.61.5-1.41.9-0.5-0.6-0.51.1-2.0-0.0
Epididymis fat weight2.96.714.13.4-3.13.8-3.72.5-2.73.1-3.12.20.1-2.30.31.7-1.9-1.1
Delta time in closed arm before/after self-admin0.80.82.20.10.10.9-0.8-0.70.20.6-0.6-0.91.5-1.41.3-1.10.0-1.4
Delta time in open arm before/after self-admin0.30.31.70.7-0.80.6-0.60.6-0.20.3-0.2-0.0-0.1-0.10.11.30.00.1
Diff in mean of infusions in LGA sessions1.51.75.00.6-0.6-0.60.51.5-0.9-0.20.21.7-2.21.6-2.21.60.01.5
Delay discount exponential model param1.11.23.20.5-0.3-1.00.91.2-0.6-0.40.30.7-1.81.4-1.71.7-0.51.4
Extinction: sum of active levers before priming0.90.93.10.3-0.3-0.30.30.8-0.0-0.60.60.4-1.21.5-1.21.70.01.8
Active lever presses in extinction session 62.01.94.9-0.50.4-1.61.60.50.2-1.41.30.8-2.22.2-2.01.10.02.0
Bone: final force0.20.41.50.8-0.80.5-0.50.7-0.30.1-0.00.4-0.50.5-0.61.2-0.30.8
Bone: final moment0.30.41.90.8-0.80.4-0.40.8-0.30.00.00.5-0.60.6-0.61.4-0.40.8
Food consumed during 24 hour testing period0.40.41.2-0.80.9-1.11.1-0.60.4-0.80.70.0-0.30.6-0.4-0.7-0.2-0.2
Glucose3.04.68.72.6-2.61.5-1.63.0-2.71.9-1.92.7-2.0-0.1-1.92.4-2.40.7
Heart weight1.31.94.21.5-1.32.0-2.00.6-0.91.7-1.7-0.21.2-1.81.30.20.5-1.4
Delay discount hyperbolic model param1.11.23.20.3-0.1-1.21.11.0-0.4-0.60.60.6-1.81.6-1.71.5-0.41.4
Intermittent access intake day 1-15 change0.70.71.5-0.90.9-1.21.2-0.30.3-1.00.90.3-0.91.2-1.0-0.40.00.9
Intermittent access intake escalation0.90.92.0-0.80.8-1.31.3-0.20.3-1.11.00.3-1.11.4-1.2-0.30.01.0
Intermittent access intake escalation 21.31.33.2-0.70.7-1.51.50.20.0-1.01.01.0-1.71.7-1.80.20.01.4
Intermitt. access day 1 inactive lever presses2.42.65.0-2.01.9-2.02.0-1.72.0-2.22.2-1.60.31.60.1-0.60.00.9
Intermitt. access day 15 inactive lever presses0.70.81.9-0.91.0-1.41.3-0.50.9-1.31.3-0.4-0.31.1-0.30.50.0-0.0
Intermitt. access escalation Index0.20.20.4-0.30.6-0.40.4-0.40.6-0.50.5-0.70.30.20.20.20.0-0.4
Intermittent access day 1 total infusions0.40.51.0-1.01.0-0.80.8-0.70.9-0.90.9-0.60.10.50.2-0.30.00.2
Intermittent access day 15 total infusions2.42.75.9-1.91.9-2.42.4-0.91.3-2.22.1-0.3-1.22.2-1.2-0.40.01.3
Intermittent access terminal intake (last 3 days)1.92.14.7-1.81.8-2.22.1-1.11.4-2.01.9-0.5-0.71.7-0.7-0.40.00.9
Intermittent access total infusions1.61.73.6-1.71.6-1.91.9-1.01.4-1.91.9-0.7-0.41.6-0.4-0.10.00.7
Intermittent access day 1 locomotion1.51.63.1-1.81.8-1.51.5-1.51.6-1.41.4-1.40.50.60.7-0.90.00.1
Intermittent access day 15 total locomotion1.21.32.9-1.11.1-1.61.6-0.10.4-1.31.30.3-1.41.7-1.40.10.01.4
Intermittent access total locomotion2.42.86.0-2.02.0-2.52.4-1.01.5-2.22.2-0.6-1.02.1-1.0-0.20.01.4
Intermittent access standard deviation1.01.02.5-0.90.8-1.51.4-0.20.5-1.21.20.4-1.21.6-1.30.10.01.1
Left kidney weight1.02.96.6-1.92.1-0.40.5-2.62.3-1.11.2-1.72.4-0.62.4-2.01.1-0.9
Right kidney weight1.54.29.4-2.42.6-1.01.1-3.12.8-1.71.8-2.12.5-0.32.3-2.31.4-1.1
Cocaine induced anxiety0.30.30.8-0.20.2-0.60.50.2-0.0-0.50.50.3-0.90.9-0.90.30.00.9
Post-drug Anxiety0.50.61.70.3-0.3-0.40.40.8-0.5-0.30.31.0-1.21.1-1.31.10.00.8
Baseline Anxiety0.00.00.1-0.0-0.0-0.20.10.0-0.00.0-0.00.20.0-0.10.10.20.0-0.4
Tail length0.51.63.4-1.41.5-1.71.7-0.91.4-1.81.8-0.6-0.31.7-0.40.10.21.0
Length with tail0.00.10.3-0.40.4-0.40.4-0.20.4-0.50.50.1-0.10.6-0.20.1-0.30.3
Length without tail0.00.10.30.3-0.20.4-0.30.1-0.20.2-0.20.40.0-0.2-0.1-0.1-0.5-0.0
Times rat made contact with spout5.26.011.8-3.43.4-3.43.4-2.72.7-2.92.8-1.90.31.60.2-2.11.50.2
Lifetime Intake0.60.71.4-1.11.0-1.11.0-0.81.1-1.11.2-0.80.10.70.2-0.10.00.2
Liver weight, left0.10.10.3-0.40.5-0.40.3-0.30.5-0.50.5-0.10.20.20.30.3-0.20.1
Liver weight, right0.10.20.5-0.40.4-0.10.1-0.50.5-0.20.2-0.50.7-0.20.7-0.10.4-0.1
Locomotor activity2.84.49.1-2.72.7-1.71.8-2.73.0-2.62.7-2.31.51.31.2-1.31.70.6
Locomotor testing distance1.52.54.3-2.01.9-2.02.0-1.51.9-2.12.1-1.60.21.50.0-0.61.30.8
Locomotor testing rearing0.61.02.0-1.31.4-0.70.7-1.41.4-1.01.1-1.01.00.30.9-0.70.6-0.1
Locomotion in novel chamber0.10.20.5-0.50.4-0.70.7-0.20.2-0.50.50.2-0.30.4-0.30.1-0.2-0.4
Locomotion in novel chamber post-restriction1.51.83.61.6-1.71.5-1.51.3-1.71.9-1.90.80.1-1.60.20.4-0.4-1.3
Fecal boli incidents, locomotor time 10.70.82.9-0.40.20.8-0.7-1.00.80.1-0.0-0.51.7-1.11.6-0.80.2-1.3
Change in fecal boli incidents, locomotor task2.01.93.1-1.71.7-1.41.4-1.81.4-1.01.0-1.60.9-0.51.2-1.61.5-1.5
Time >=10cm from walls, locomotor time 10.50.51.4-0.60.8-1.21.2-0.50.8-1.01.0-0.4-0.20.6-0.10.20.1-0.5
Bouts of movement, locomotor time 10.30.30.70.3-0.40.5-0.50.4-0.70.4-0.50.8-0.3-0.1-0.7-0.5-0.80.4
Total resting periods, locomotor time 10.20.20.60.2-0.20.3-0.30.3-0.40.1-0.20.7-0.30.2-0.7-0.3-0.80.6
Rest time, locomotor task time 10.70.71.90.3-0.41.4-1.3-0.3-0.00.8-0.80.21.3-1.31.2-0.7-0.4-0.6
Distance moved, locomotor task time 10.60.72.4-0.30.4-1.41.3-0.10.4-0.70.7-1.2-0.70.8-0.50.21.60.4
Vertical activity count, locomotor time 10.50.51.70.2-0.4-0.90.90.6-0.2-0.40.4-0.1-1.31.0-1.11.00.40.7
Time >=10cm from walls, locomotor time 20.40.40.90.9-0.90.4-0.50.6-0.60.8-0.7-0.00.1-0.70.30.70.3-0.9
Bouts of movement, locomotor time 21.51.65.41.3-1.01.4-1.41.4-1.21.1-1.02.1-0.4-0.4-0.41.4-2.30.1
Total resting periods, locomotor time 20.50.52.80.6-0.30.8-0.80.6-0.40.4-0.41.4-0.1-0.2-0.10.9-1.70.1
Rest time, locomotor task time 20.30.31.0-0.90.8-0.50.6-0.80.6-0.50.5-0.00.2-0.10.1-1.0-0.2-0.4
Distance moved, locomotor task time 20.40.51.11.0-1.00.6-0.70.9-0.80.9-0.9-0.3-0.1-0.40.00.80.80.3
Vertical activity count, locomotor time 20.70.82.21.3-1.41.0-1.01.0-0.70.9-0.8-0.20.1-0.50.21.50.6-0.2
Light reinforcement 10.40.83.40.2-0.10.8-0.8-0.30.00.6-0.6-0.11.4-1.41.4-0.10.0-1.8
Light reinforcement 22.93.97.22.3-2.32.4-2.42.0-2.02.1-2.02.5-0.1-1.2-0.02.0-2.7-0.6
Bone: marrow area2.24.810.12.8-2.83.2-3.22.0-2.32.8-2.81.50.4-2.20.51.2-1.2-1.3
Bone: maximum diameter0.61.12.41.3-1.30.9-0.91.3-1.00.7-0.71.5-0.90.1-0.81.3-1.60.3
Bone: maximum force0.30.51.10.9-0.90.5-0.51.0-0.70.3-0.30.6-0.80.5-0.91.1-0.41.0
Bone: maximum moment0.30.51.30.8-0.80.5-0.51.0-0.60.3-0.20.7-0.70.5-0.81.2-0.50.9
Mean time between licks in bursts1.82.64.7-1.92.0-1.61.7-2.01.6-1.31.3-2.10.90.10.8-2.12.2-0.5
Mean num. licks in bursts1.11.32.9-1.11.0-1.71.7-0.30.6-1.41.40.2-1.31.6-1.20.1-0.51.3
Cd content in liver1.51.63.7-1.21.3-1.61.6-0.81.2-1.51.5-1.7-0.21.3-0.3-0.11.91.0
Co content in liver0.30.42.40.2-0.20.4-0.4-0.1-0.20.6-0.60.00.6-1.10.8-0.3-0.0-1.6
Cu content in liver0.10.11.10.3-0.1-0.10.10.6-0.30.1-0.10.1-0.50.3-0.31.0-0.10.4
Fe content in liver0.70.82.70.8-0.7-0.80.71.2-0.7-0.10.10.1-1.60.9-1.41.60.40.7
K content in liver0.60.61.61.0-1.01.2-1.20.5-0.30.6-0.5-0.30.5-0.50.51.10.5-0.2
Mg content in liver0.60.61.41.1-1.11.2-1.20.9-0.80.7-0.70.0-0.2-0.2-0.30.90.30.3
Mn content in liver1.31.53.01.0-1.21.7-1.70.6-1.01.4-1.41.50.6-1.40.5-0.0-1.6-1.2
Na content in liver2.62.76.82.0-2.11.2-1.32.3-1.71.1-1.12.0-1.50.3-1.32.6-2.00.7
Rb content in liver0.20.30.5-0.60.7-0.40.4-0.70.6-0.30.4-0.70.7-0.00.6-0.40.6-0.2
Se content in liver0.60.71.6-0.30.3-1.21.20.20.3-0.90.9-0.5-1.01.3-0.91.00.60.8
Sr content in liver1.81.63.2-1.61.5-1.21.2-1.81.8-1.41.4-1.41.00.31.0-1.21.0-0.2
Zn content in liver0.50.61.3-0.60.5-1.11.1-0.40.8-1.11.1-0.6-0.41.0-0.40.40.50.4
Bone: minimum diameter2.44.58.22.9-2.92.3-2.32.6-2.72.4-2.42.3-1.3-1.0-1.21.5-1.8-0.2
Time in familiar zone, hab. session 10.30.31.3-0.30.30.3-0.3-0.3-0.20.3-0.30.70.4-0.50.1-1.2-0.9-0.6
Time in novel zone, hab. session 10.60.51.21.0-1.00.8-0.80.7-0.60.8-0.8-0.60.1-0.60.20.81.1-0.2
Total zone transitions, hab. session 11.31.83.8-1.91.8-1.41.5-1.71.9-1.71.7-0.91.00.70.9-0.60.3-0.2
Total locomotion distance, hab. session 11.21.73.3-1.81.8-1.31.4-1.71.8-1.51.5-1.21.00.51.0-0.70.7-0.2
Locomotion velocity, hab. session 11.31.83.5-1.91.8-1.51.5-1.61.9-1.61.6-1.10.90.70.9-0.60.60.1
Time in familiar zone, hab. session 20.70.71.80.5-0.51.3-1.3-0.0-0.51.0-1.00.60.7-1.20.5-1.0-0.7-0.8
Time in novel zone, hab. session 20.30.30.6-0.20.3-0.70.70.10.3-0.50.5-0.6-0.40.7-0.20.70.80.7
Total zone transitions, hab. session 20.81.02.4-1.51.5-0.60.6-1.51.3-0.90.9-0.21.00.10.9-1.5-0.40.0
Total locomotion distance, hab. session 21.62.14.7-2.12.2-1.01.0-2.11.8-1.21.2-1.01.40.21.3-2.10.40.3
Locomotion velocity, hab. session 21.52.14.8-2.22.2-1.11.1-2.11.8-1.31.3-0.91.30.31.2-2.00.30.5
Novel to familiar place preference ratio0.20.20.8-0.10.1-0.20.1-0.00.3-0.00.1-0.80.5-0.10.60.60.9-0.2
Novelty place preference0.20.30.60.3-0.30.3-0.40.2-0.10.5-0.4-0.60.7-0.50.80.80.7-0.5
Time in novel zone, NPP test0.30.30.60.5-0.40.6-0.60.3-0.30.7-0.6-0.40.7-0.70.80.70.6-0.6
Total zone transitions, NPP test0.20.31.3-0.50.5-0.30.3-0.30.2-0.40.30.7-0.20.4-0.3-0.6-1.10.5
Total locomotion distance, NPP test0.20.30.7-0.80.8-0.40.4-0.70.6-0.40.4-0.20.50.00.5-0.7-0.10.1
Locomotion velocity, NPP test0.30.41.1-1.01.1-0.70.7-0.90.7-0.60.6-0.20.50.30.5-0.8-0.10.3
Intraocular pressure0.50.71.90.4-0.70.9-0.90.2-0.81.1-1.2-0.20.5-1.40.4-0.90.7-1.1
Delta distance traveled before/after self-admin1.01.14.3-0.20.20.7-0.7-1.00.90.10.0-1.72.1-1.12.0-0.30.0-1.4
Delta ambulatory time before/after self-admin1.11.24.5-0.40.40.6-0.5-1.21.1-0.10.2-1.92.1-1.02.0-0.50.0-1.2
Parametrial fat weight1.32.66.91.7-1.62.6-2.60.9-1.42.1-2.10.81.0-2.10.9-0.1-0.7-1.2
Pavlov. Cond. lever latency0.20.21.0-0.30.30.3-0.2-0.50.3-0.00.0-0.60.6-0.30.4-1.00.80.1
Pavlov. Cond. magazine entry latency0.30.40.7-0.80.8-0.40.5-0.80.7-0.40.3-0.80.7-0.30.7-0.80.8-0.6
Pavlov. Cond. change in total contacts0.20.21.0-0.10.1-0.10.1-0.00.00.1-0.10.60.3-0.30.40.3-0.9-1.0
Pavlov. Cond. index score0.10.10.2-0.30.3-0.50.5-0.20.4-0.30.4-0.20.10.10.30.40.0-0.5
Pavlov. Cond. latency score0.10.20.3-0.40.4-0.50.5-0.30.5-0.40.4-0.30.30.10.50.50.1-0.5
Pavlov. Cond. lever contacts0.40.41.3-0.30.3-0.80.80.20.3-0.70.70.5-0.60.9-0.51.1-0.80.4
Pavlov. Cond. magazine entry number0.10.10.40.2-0.20.1-0.10.3-0.2-0.00.00.5-0.40.4-0.40.4-0.60.6
Pavlov. Cond. intertrial magazine entries4.04.99.92.6-2.61.0-1.03.1-2.71.3-1.42.4-3.00.9-2.92.6-1.81.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.20.2-0.40.4-0.20.3-0.30.3-0.10.20.10.30.40.0-0.5
Pavlov. Cond. response bias0.10.10.3-0.50.5-0.50.5-0.30.2-0.30.30.1-0.10.1-0.1-0.5-0.1-0.2
Pavlov. Cond. lever latency1.01.33.5-1.31.4-1.01.0-1.31.0-0.70.7-1.70.60.10.6-1.61.90.3
Pavlov. Cond. magazine entry latency0.10.10.4-0.20.2-0.10.1-0.10.5-0.60.60.30.10.5-0.00.6-0.60.0
Pavlov. Cond. change in total contacts0.71.02.71.1-1.11.3-1.30.8-0.80.9-0.91.40.2-0.70.10.8-1.6-0.7
Pavlov. Cond. index score0.30.41.40.4-0.50.2-0.20.6-0.1-0.20.30.9-0.50.5-0.61.1-1.20.1
Pavlov. Cond. latency score0.10.20.70.1-0.10.1-0.10.10.2-0.40.50.5-0.00.4-0.20.8-0.9-0.2
Pavlov. Cond. lever contacts0.50.72.01.0-1.10.9-0.90.8-0.60.6-0.51.2-0.1-0.3-0.11.1-1.4-0.6
Pavlov. Cond. magazine entry number0.20.20.6-0.30.4-0.80.7-0.10.1-0.30.3-0.4-0.50.5-0.3-0.10.50.7
Pavlov. Cond. intertrial magazine entries0.40.51.90.3-0.4-0.10.10.7-0.70.2-0.20.6-1.30.6-1.20.1-0.41.4
Pavlov. Cond. lever-magazine prob. diff.0.20.31.60.3-0.30.2-0.20.4-0.1-0.30.30.9-0.40.5-0.61.0-1.20.1
Pavlov. Cond. response bias0.40.62.50.8-0.90.8-0.80.7-0.60.4-0.41.3-0.3-0.1-0.30.9-1.6-0.3
Time in closed arm before self-admin0.30.30.70.6-0.70.7-0.70.3-0.60.8-0.80.40.3-0.70.3-0.10.0-0.6
Time in closed arm after self-admin3.33.48.90.5-0.51.9-1.9-0.8-0.31.9-1.8-0.72.8-3.02.5-2.10.0-2.9
Time in open arm before self-admin0.10.10.2-0.40.3-0.20.2-0.30.3-0.20.2-0.20.2-0.00.2-0.20.0-0.3
Time in open arm after self-admin0.70.82.80.3-0.4-0.40.30.9-0.2-0.50.50.5-1.51.2-1.21.70.01.5
Bone: periosteal estimation0.91.83.31.8-1.81.7-1.71.5-1.41.5-1.41.3-0.3-0.7-0.21.4-1.2-0.3
Bone: periosteal perimeter0.60.93.60.8-0.80.6-0.61.0-0.90.5-0.51.7-0.90.4-1.00.8-1.90.8
Bone: post-yield work0.81.12.21.2-1.20.5-0.51.5-1.30.6-0.71.2-1.50.4-1.41.1-1.00.8
Progressive ratio test 1 active lever presses0.50.51.6-0.80.8-0.30.3-1.01.0-0.50.6-1.31.0-0.11.0-0.60.0-0.3
Progressive ratio test 1 breakpoint1.01.02.9-1.01.0-0.20.3-1.41.3-0.60.7-1.71.5-0.41.5-0.80.0-0.7
Progressive ratio test 1 inactive lever presses0.91.01.9-1.21.1-1.21.2-0.91.3-1.31.4-1.1-0.01.00.1-0.20.00.6
Progressive ratio test 2 active lever presses1.41.53.3-1.51.5-1.81.8-0.70.8-1.51.5-0.0-1.01.6-0.9-0.50.01.1
Progressive ratio test 2 breakpoint1.31.53.2-1.41.4-1.81.8-0.50.8-1.51.50.1-1.21.7-1.1-0.30.01.3
Progressive ratio test 2 inactive lever presses2.73.17.0-1.81.8-2.62.6-0.71.3-2.32.2-0.1-1.72.5-1.50.20.01.6
Incentive Sensitization - Responses1.31.34.1-0.30.3-1.11.00.7-0.4-0.70.61.4-2.01.7-1.90.50.01.7
Incentive Sensitization - Breakpoint1.51.54.7-0.40.4-1.21.20.7-0.4-0.70.61.5-2.21.8-2.10.50.01.8
Sum of active levers in priming session hrs 5-62.22.18.90.1-0.2-0.80.71.00.0-1.11.10.7-1.92.4-1.92.10.03.0
Progressive ratio0.00.10.20.3-0.20.3-0.30.2-0.20.1-0.10.2-0.1-0.2-0.10.3-0.3-0.4
Food seeking constrained by brief footshock1.31.62.7-1.41.5-1.71.6-1.31.6-1.41.4-1.60.60.70.7-0.21.5-0.3
Seeking ratio, punishment vs. effort0.91.12.6-1.21.1-1.21.2-1.11.2-1.01.0-1.50.70.50.7-0.61.60.1
Retroperitoneal fat weight1.54.98.42.9-2.72.8-2.82.4-2.82.8-2.82.2-0.6-1.7-0.51.1-1.8-0.5
Reaction time number correct0.30.41.30.1-0.2-0.30.30.5-0.4-0.10.11.0-0.90.7-0.80.4-1.20.7
Reaction time mean minus median0.40.61.4-0.60.7-1.11.1-0.10.3-0.80.80.2-0.91.2-0.80.1-0.31.0
Reaction time mean minus median AUC0.60.82.00.00.1-0.70.60.6-0.3-0.50.51.1-1.41.3-1.40.7-1.31.1
Reaction time num false alarms2.33.16.1-2.12.1-1.81.8-2.01.8-1.71.7-2.30.70.80.4-2.12.50.7
Reaction time num false alarms AUC2.53.56.7-2.42.3-1.71.7-2.42.0-1.71.6-2.41.00.50.8-2.62.40.5
Reaction time trials correct on left0.30.41.30.1-0.2-0.30.30.5-0.4-0.10.11.0-0.90.7-0.80.4-1.20.7
Reaction time trials on left0.30.41.40.1-0.2-0.30.30.5-0.4-0.10.11.0-0.90.7-0.80.4-1.20.8
Reaction time mean0.10.20.80.5-0.30.5-0.50.3-0.40.5-0.5-0.50.1-0.50.20.00.9-0.4
Reaction time mean AUC0.00.10.30.3-0.10.1-0.10.3-0.20.1-0.1-0.3-0.2-0.0-0.20.20.5-0.0
Median of all reaction times0.60.81.80.9-0.71.1-1.10.3-0.61.1-1.1-0.70.7-1.30.7-0.21.2-1.0
Reaction time omissions0.00.00.10.1-0.10.1-0.1-0.10.2-0.10.2-0.10.10.20.20.30.10.3
Reaction time false alarm rate2.33.37.4-2.12.1-1.41.4-2.31.9-1.41.4-2.61.30.11.1-2.52.7-0.0
Reaction time premature initiation rate0.70.91.71.0-1.31.3-1.20.8-1.01.2-1.21.00.3-1.00.30.4-1.0-0.9
Reaction time premature initiations0.60.92.50.9-1.20.7-0.81.0-1.00.8-0.81.5-0.5-0.1-0.50.8-1.6-0.0
Std. dev. reaction times0.30.51.1-0.70.8-1.11.0-0.40.5-0.80.8-0.4-0.40.9-0.4-0.10.30.6
Reaction time trials completed0.30.41.40.1-0.2-0.30.30.5-0.4-0.10.11.0-0.90.7-0.80.4-1.20.8
Reaction time trials AUC0.30.41.30.3-0.4-0.10.10.7-0.60.1-0.11.0-0.90.5-0.80.6-1.10.7
Run reversals in cocaine runway, females0.30.30.8-0.70.7-0.00.1-0.70.7-0.50.5-0.30.90.00.6-0.40.1-0.5
Run reversals in cocaine runway, males0.60.62.4-0.20.4-0.40.40.3-0.2-0.50.41.2-0.91.0-1.10.3-1.50.7
Latency to leave start box in cocaine runway0.40.41.20.2-0.20.3-0.3-0.0-0.60.9-0.90.50.1-1.10.4-1.1-0.4-0.7
Latency to leave start box in cocaine runway, F0.30.41.4-0.30.20.2-0.2-0.60.10.4-0.4-0.60.8-0.90.9-1.20.8-0.4
Latency to leave start box in cocaine runway, M0.70.62.00.7-0.50.4-0.40.9-1.10.8-0.91.4-0.8-0.3-0.60.2-1.40.0
Std. dev. time between licks in bursts0.60.71.8-0.80.8-1.31.3-0.40.6-1.11.1-0.1-0.71.1-0.8-0.0-0.10.5
Total sessions with >9 infusions0.91.03.0-0.90.7-0.30.3-1.31.3-0.50.6-1.71.5-0.51.5-0.70.0-1.0
Short access day 1 total inactive lever presses1.92.14.8-1.61.5-2.01.9-1.21.7-2.12.2-1.0-0.21.9-0.40.10.01.1
Short access day 10 total inactive lever presses0.30.41.10.4-0.50.1-0.10.8-0.40.00.00.8-0.70.7-0.91.10.00.7
Short access day 1 total infusions0.10.20.5-0.20.20.0-0.0-0.40.6-0.30.4-0.70.60.00.70.30.00.0
Short access day 10 total infusions0.50.51.70.1-0.10.5-0.5-0.50.40.2-0.2-1.01.2-0.91.30.00.0-1.3
Short access total infusions0.60.72.7-0.20.00.5-0.4-0.80.80.00.1-1.51.5-0.91.6-0.10.0-1.2
Short access day 1 locomotion0.80.92.9-1.00.9-0.40.4-1.31.3-0.70.7-1.71.3-0.21.3-0.70.0-0.4
Short access day 10 total locomotion0.10.10.7-0.30.20.1-0.1-0.30.4-0.30.3-0.70.30.20.40.00.00.8
Short access total locomotion0.60.62.3-0.30.20.3-0.2-0.80.70.00.0-1.31.3-0.81.5-0.30.0-0.9
One hour access (0.3 mA shock)0.80.91.8-1.11.1-1.31.3-0.50.8-1.21.2-0.2-0.71.3-0.7-0.20.01.0
Compulsive drug intake0.50.50.90.9-0.90.9-0.90.6-0.50.8-0.80.10.3-0.80.50.70.0-0.8
One hour access (shock baseline)1.61.94.0-1.41.4-2.01.9-0.40.8-1.61.60.2-1.42.0-1.4-0.10.01.6
Social response proportion0.60.61.5-0.80.8-0.50.5-1.10.9-0.60.6-1.20.6-0.00.5-1.11.2-0.4
Social responses0.70.91.7-1.01.1-0.40.4-1.31.0-0.50.5-1.11.1-0.71.2-1.20.9-1.2
Social time0.10.10.30.4-0.40.5-0.50.2-0.00.1-0.1-0.10.1-0.10.10.50.20.2
Soleus weight0.41.36.11.6-1.61.3-1.41.3-0.70.8-0.60.80.0-0.20.22.5-0.9-0.1
Bone: stiffness0.20.31.6-0.10.1-0.40.40.10.3-0.60.6-0.1-0.51.1-0.50.70.11.3
Tibialis anterior weight5.619.334.45.8-5.94.8-4.95.2-5.65.4-5.44.3-1.6-3.0-1.33.3-3.4-1.6
Time to tail flick, vehicle, before self-admin2.22.34.5-1.92.1-2.02.0-1.91.8-1.61.7-1.50.70.40.8-1.30.0-0.7
Time to tail flick, vehicle, after self-admin1.81.94.11.6-1.61.8-1.80.9-1.51.9-1.90.60.5-2.00.6-0.10.0-1.5
Time to tail flick, test, before self-admin1.00.92.6-0.90.9-0.20.2-1.31.0-0.20.2-1.21.6-0.81.5-1.20.0-1.0
Time to tail flick, test, after self-admin1.41.54.2-0.81.00.2-0.1-1.51.3-0.30.3-1.92.1-1.02.0-1.10.0-1.5
Delta time to tail flick, vehicle, before/after SA2.92.95.52.3-2.42.3-2.31.9-2.12.1-2.21.4-0.3-1.3-0.30.90.0-0.2
Delta time to tail flick, test, before/after SA0.00.00.20.00.00.1-0.1-0.10.2-0.20.2-0.50.20.10.10.20.0-0.2
Tibia length0.00.10.40.00.00.2-0.2-0.10.20.0-0.0-0.30.5-0.30.60.40.2-0.6
Ambulatory time before self-admin0.40.50.90.8-0.90.4-0.40.9-0.70.4-0.40.9-0.70.4-0.81.00.00.7
Ambulatory time after self-admin0.30.30.90.7-0.80.9-0.90.3-0.00.4-0.3-0.40.7-0.20.50.90.00.1
Bone: tissue strength0.40.40.9-0.60.6-0.50.5-0.70.6-0.50.4-0.90.4-0.10.4-0.71.0-0.5
Total heroin consumption2.73.18.9-1.61.6-2.02.0-0.81.8-2.32.4-0.9-0.72.7-0.71.00.03.0
Bone: trabecular number0.10.10.4-0.10.10.2-0.2-0.1-0.20.4-0.40.20.3-0.50.4-0.6-0.2-0.1
Bone: trabecular spacing1.21.63.2-1.71.7-1.01.0-1.81.7-1.31.3-1.41.10.21.0-1.41.1-0.4
Bone: trabecular thickness0.81.02.21.0-1.00.9-0.91.0-1.51.3-1.41.2-0.8-0.7-0.7-0.5-0.90.1
Bone: trabecular tissue density0.81.24.9-1.51.5-0.50.6-1.61.1-0.70.7-0.61.1-0.20.8-2.20.3-0.5
Water consumed over 24 hours0.40.50.9-0.91.0-0.70.8-0.90.9-1.00.9-0.50.20.5-0.0-0.90.3-0.1
Number of responses in last shaping day1.01.02.6-0.80.8-0.10.1-1.41.1-0.30.3-1.41.6-0.81.6-1.20.0-1.1