Ror1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Ror1	0.1	0.07	2.7e-06	0.06	0.06	0.06	0.06	1.4e-06	2.3e-06	6.2e-06	2.6e-06
2	LHb	gene expression	Ror1	0.15	0.1	3.0e-03	0.09	0.08	0.03	0.04	3.6e-03	5.4e-03	6.8e-02	3.4e-02
3	pVTA	gene expression	Ror1	0.18	0.1	6.9e-10	0.13	0.12	0.12	0.12	1.1e-10	1.7e-09	5.9e-10	1.4e-09
4	NAcc	gene expression	Ror1	0.29	0.12	0.0e+00	0.17	0.16	0.17	0.17	9.2e-25	5.3e-23	6.6e-25	8.0e-25
5	PL	gene expression	Ror1	0.07	0.05	1.1e-03	0.02	0.02	0.02	0.01	2.7e-03	1.5e-03	6.4e-03	9.8e-03
6	BLA	gene expression	Ror1	0.18	0.12	3.0e-03	0.03	0.04	0.01	0.05	1.3e-02	4.8e-03	9.6e-02	1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.5	0.9	1.6	1.0	0.8	1.2	1.3	-0.7	-0.6
Area under the delay curve	0.2	0.4	0.7	0.5	0.5	0.8	0.5	0.7	-0.5
BMI with tail	0.4	1.4	2.8	-1.6	-1.7	-1.1	-1.1	0.5	-0.7
BMI without tail	0.4	2.3	4.3	-2.0	-2.1	-1.6	-1.4	1.2	0.4
Body weight	0.2	0.8	2.0	-1.4	-1.3	-0.7	-0.4	-0.1	-0.6
Weight adjusted by age	0.4	1.0	3.2	-0.9	-1.3	-0.5	-0.5	1.8	0.3
Bone surface	0.5	0.9	2.5	-1.3	-1.6	-0.8	-0.7	0.4	-0.0
Bone volume	0.1	0.1	0.4	-0.4	-0.6	0.1	0.2	0.2	-0.2
Breakpoint value in progressive ratio session	0.5	1.0	2.7	0.6	1.1	0.4	0.6	-1.6	-1.0
Number of licking bursts	0.1	0.3	0.5	-0.5	-0.1	-0.7	-0.7	0.6	0.5
Context. condit. distance diff. score	4.3	5.3	7.7	2.2	2.0	2.1	2.0	-2.8	-2.5
Locomotion velocity, session 1	0.3	0.4	0.7	-0.6	-0.6	-0.9	-0.8	-0.1	0.2
Locomotion distance, session 1	0.3	0.3	0.6	0.7	0.8	0.4	0.4	-0.8	-0.0
Locomotion velocity, session 2	0.1	0.2	0.3	0.5	-0.3	0.3	0.3	0.5	0.5
Locomotion distance, session 2	0.3	0.5	1.3	-0.4	-0.3	-0.7	-0.8	0.2	1.2
Locomotion velocity, session 3	0.1	0.1	0.4	0.3	0.7	-0.1	-0.2	-0.2	0.4
Locomotion distance, session 3	0.0	0.1	0.2	-0.1	0.4	-0.1	-0.2	-0.1	0.1
Stereotopy head waving bouts, day 3	0.7	0.8	1.2	1.1	1.0	1.1	1.1	-0.5	-0.2
Stereotopy head waving duration, day 3	0.8	0.9	1.8	1.3	1.0	1.2	1.2	-0.5	0.1
Locomotion velocity, session 7	1.4	1.5	2.2	1.3	1.5	1.4	1.3	-1.2	-0.2
Locomotion distance, session 7	0.7	0.8	1.0	1.0	1.0	1.0	0.9	-1.0	-0.4
Stereotopy head waving bouts, day 7	0.5	0.6	0.8	-0.9	-0.9	-0.8	-0.8	0.8	0.3
Stereotopy head waving duration, day 7	1.2	1.5	1.9	-1.4	-1.1	-1.3	-1.3	1.2	1.0
Locomotion velocity, session 8	0.2	0.3	0.8	0.5	0.7	0.3	0.3	-0.9	-0.3
Locomotion distance, session 8	1.1	1.6	3.3	1.3	1.3	1.1	1.0	-1.8	-0.6
Degree of sensitization distance	0.1	0.1	0.3	0.2	-0.2	0.3	0.3	-0.4	-0.5
Degree of sensitization stereotypy	1.1	1.2	1.5	-1.2	-1.2	-1.2	-1.2	1.1	0.7
Conditioned locomotion	0.1	0.1	0.2	0.1	0.3	-0.4	-0.4	-0.1	0.0
Cocaine response after cond. corrected	0.5	0.8	1.3	-0.9	-0.5	-1.1	-1.1	0.9	0.7
Cocaine response after cond. not corrected	0.4	0.5	1.0	-1.0	-0.3	-0.9	-0.9	0.4	0.5
Cocaine response before conditioning	0.1	0.1	0.5	-0.1	0.1	0.4	0.4	-0.7	-0.0
Saline control response	0.1	0.1	0.2	-0.1	-0.4	-0.2	-0.2	0.4	0.4
Bone: connectivity density	0.7	1.1	2.3	-1.3	-1.5	-1.0	-0.9	0.9	0.4
Bone: cortical apparent density	3.6	5.7	8.4	2.9	2.9	2.5	2.6	-2.1	-0.4
Bone: cortical area	0.3	0.6	0.8	-0.7	-0.9	-0.8	-0.7	0.5	0.8
Bone: cortical porosity	0.5	0.5	0.7	-0.9	-0.9	-0.7	-0.8	0.3	-0.4
Bone: cortical porosity	0.8	0.9	1.4	-1.2	-1.1	-1.1	-1.1	0.6	-0.3
Bone: cortical thickness	0.1	0.2	0.3	0.4	0.3	0.3	0.3	-0.5	-0.4
Bone: cortical thickness	0.3	0.4	0.7	0.6	0.2	0.4	0.5	-0.8	-0.8
Bone: cortical tissue density	3.5	5.6	8.2	2.9	2.9	2.5	2.5	-2.1	-0.4
Condit. Reinf. active minus inactive responses	0.8	0.9	1.6	-1.1	-0.8	-1.2	-1.2	0.5	0.7
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.3	-1.0	-0.3	-1.1	-1.1	-0.1	0.4
Condit. Reinf. active responses	1.6	2.1	3.3	-1.8	-1.3	-1.8	-1.7	1.0	0.7
Condit. Reinf. inactive responses	0.7	0.9	1.6	-1.3	-0.9	-1.0	-1.0	0.8	0.2
Incentive salience index mean	1.0	1.3	2.2	-1.4	-1.0	-1.5	-1.5	0.3	0.7
Condit. Reinf. lever presses	0.3	0.5	0.8	-0.9	-0.5	-0.9	-0.9	-0.6	-0.1
Condit. Reinf. active minus inactive responses	0.7	1.1	2.2	0.8	1.0	1.1	1.1	-1.5	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.5	0.1	0.4	0.1	0.2	-0.7	0.3
Condit. Reinf. active responses	0.8	1.2	2.9	0.7	0.8	1.1	1.1	-1.7	-1.0
Condit. Reinf. inactive responses	1.2	1.8	2.3	1.2	1.1	1.5	1.5	-1.5	-1.2
Condit. Reinf. lever presses	1.3	1.9	3.0	-1.7	-1.7	-1.4	-1.4	0.6	1.0
Condit. Reinf. lever reinforcers received	0.4	0.6	1.7	0.3	0.4	0.8	0.8	-1.3	-0.8
Conditioned reinforcement - actives	0.0	0.2	0.5	-0.1	-0.2	-0.5	-0.5	0.0	0.7
Conditioned reinforcement - inactives	0.2	0.6	1.5	0.3	0.3	0.7	0.6	-1.1	-1.2
Conditioned locomotion	0.2	0.2	0.5	-0.4	0.0	-0.7	-0.7	-0.2	0.5
Patch foraging indifference point 0 sec	3.0	8.3	13.6	-3.6	-3.7	-3.2	-2.9	2.3	0.4
Patch foraging indifference point AUC	0.8	1.9	2.7	-1.6	-1.4	-1.2	-1.4	1.3	1.2
Delay disc. indifference point, 0s delay	3.1	3.5	5.3	1.5	1.6	2.3	2.2	-1.0	-2.2
Delay disc. indifference point, 16s delay	1.4	2.0	3.0	-1.6	-1.2	-1.4	-1.6	1.7	0.7
Delay disc. indifference point, 2s delay	1.2	1.3	2.7	0.8	0.8	1.5	1.3	-0.1	-1.6
Delay disc. indifference point, 24s delay	0.1	0.2	0.4	-0.1	0.1	-0.4	-0.5	0.6	0.6
Delay disc. indifference point, 4s delay	1.9	2.0	4.3	1.8	1.1	2.1	1.6	0.0	-1.0
Delay disc. indifference point, 8s delay	0.4	0.7	1.4	1.1	0.8	1.2	0.8	0.2	-0.3
Indifference point function ln k	0.5	1.4	2.0	1.4	0.9	1.1	1.1	-1.2	-1.3
Indifference point function log k	0.5	1.4	2.0	1.4	0.9	1.1	1.1	-1.2	-1.3
Patch foraging total patch changes 0 sec	2.7	8.0	13.0	-3.6	-3.6	-3.1	-2.8	2.2	0.4
Patch foraging total patch changes 12 sec	1.8	2.4	3.6	-1.9	-1.6	-1.7	-1.6	1.5	0.8
Patch foraging total patch changes 18 sec	1.6	3.8	6.6	-2.5	-2.6	-2.2	-2.1	1.1	0.3
Patch foraging total patch changes 24 sec	0.5	1.7	3.7	-1.9	-1.6	-1.4	-1.2	0.7	-0.4
Patch foraging total patch changes 6 sec	3.8	6.5	11.9	-3.5	-2.8	-2.7	-2.6	2.0	1.2
Patch foraging time to switch 0 sec	0.2	0.8	2.2	1.2	1.5	0.3	0.4	-0.2	0.9
Patch foraging water rate 0 sec	0.4	1.4	2.6	-1.5	-1.6	-1.1	-1.1	1.0	0.0
Patch foraging water rate 12 sec	0.5	2.2	3.9	-1.8	-2.0	-1.8	-1.6	0.4	-0.4
Patch foraging water rate 18 sec	0.3	0.6	1.4	-1.2	-0.6	-0.9	-0.7	0.0	-0.6
Patch foraging water rate 24 sec	0.2	0.4	1.8	-0.1	-0.0	-0.1	0.1	-0.6	-1.3
Patch foraging water rate 6 sec	0.2	0.3	0.6	0.3	-0.1	0.5	0.7	-0.5	-0.8
Seeking ratio, delayed vs. immediate footshock	0.9	1.3	5.8	0.2	-0.1	0.5	0.6	-1.2	-2.4
Distance traveled before self-admin	0.1	0.3	0.6	-0.5	-0.8	-0.7	-0.6	-0.1	-0.4
Distance traveled after self-admin	0.5	0.9	1.2	-0.7	-0.9	-1.0	-1.0	1.1	1.0
Extensor digitorum longus weight	0.7	2.7	5.0	1.0	1.5	1.3	1.4	-2.1	-2.2
Bone: elastic displacement	0.7	0.9	1.5	0.8	0.7	1.0	0.8	-1.1	-1.2
Bone: elastic work	1.3	1.7	2.1	1.2	1.2	1.4	1.4	-1.2	-1.3
Bone: endosteal estimation	0.3	0.7	1.7	-1.2	-1.3	-0.7	-0.6	0.0	-0.3
Bone: endosteal perimeter	1.1	2.6	3.5	-1.7	-1.9	-1.6	-1.6	1.4	1.4
Epididymis fat weight	0.0	0.1	0.2	0.4	-0.1	-0.1	-0.1	-0.4	-0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	-0.2	0.1	0.0	-0.1	-0.3	-0.6
Delta time in open arm before/after self-admin	1.9	2.2	2.9	-1.0	-1.7	-1.5	-1.4	1.6	1.6
Diff in mean of infusions in LGA sessions	0.1	0.3	0.8	-0.9	-0.2	-0.5	-0.3	-0.5	-0.4
Delay discount exponential model param	0.2	0.3	0.6	-0.5	-0.4	-0.8	-0.4	-0.7	0.5
Extinction: sum of active levers before priming	1.1	1.7	2.4	1.3	1.0	1.3	1.3	-1.3	-1.5
Active lever presses in extinction session 6	0.2	0.2	0.6	-0.3	-0.2	-0.4	-0.3	-0.8	-0.6
Bone: final force	0.2	0.4	1.0	0.5	0.7	0.5	0.6	-1.0	-0.0
Bone: final moment	0.1	0.1	0.5	-0.1	0.0	0.0	0.1	-0.7	-0.0
Food consumed during 24 hour testing period	0.3	0.5	1.0	0.9	0.8	0.4	0.6	-0.4	1.0
Glucose	0.2	0.3	0.5	-0.7	-0.5	-0.5	-0.7	-0.1	-0.6
Heart weight	2.5	4.1	7.4	1.4	2.0	2.0	2.1	-2.7	-1.7
Delay discount hyperbolic model param	0.3	0.4	0.9	-0.6	-0.4	-0.9	-0.5	-0.8	0.5
Intermittent access intake day 1-15 change	0.1	0.6	2.2	0.1	0.6	-0.5	-0.5	0.7	1.5
Intermittent access intake escalation	0.1	0.6	2.1	0.6	1.0	-0.1	-0.2	0.6	1.4
Intermittent access intake escalation 2	0.2	0.4	1.1	0.0	0.8	-0.5	-0.4	0.2	1.0
Intermitt. access day 1 inactive lever presses	0.1	1.2	5.2	-0.5	-0.4	0.8	0.5	-0.8	-2.3
Intermitt. access day 15 inactive lever presses	0.5	2.8	4.5	1.4	1.5	1.7	1.6	-2.1	-1.5
Intermitt. access escalation Index	0.3	0.9	1.4	0.8	0.0	1.2	1.1	1.2	0.9
Intermittent access day 1 total infusions	0.2	0.7	1.1	1.0	0.6	1.0	0.8	-0.9	-0.4
Intermittent access day 15 total infusions	0.3	0.6	1.2	1.0	1.1	0.5	0.3	0.1	1.0
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.6	0.4	0.2	0.0	-0.0	0.5
Intermittent access total infusions	0.4	0.5	1.4	1.2	1.0	0.6	0.3	-0.5	0.4
Intermittent access day 1 locomotion	0.1	0.2	0.9	-0.0	-0.1	-0.4	-0.6	0.1	0.9
Intermittent access day 15 total locomotion	0.3	1.1	2.5	-0.5	-0.6	-1.2	-1.3	0.7	1.6
Intermittent access total locomotion	0.3	0.4	0.9	0.1	0.1	-0.7	-1.0	-0.0	0.9
Intermittent access standard deviation	0.0	0.2	0.6	0.5	0.8	-0.3	-0.3	-0.2	0.4
Left kidney weight	0.1	0.5	1.9	0.0	0.7	0.3	0.4	-1.4	-0.8
Right kidney weight	0.3	1.8	3.7	0.7	1.2	1.3	1.4	-1.9	-1.3
Cocaine induced anxiety	0.5	1.4	5.5	0.3	-0.0	-0.2	-0.3	1.7	2.3
Post-drug Anxiety	0.9	1.0	1.3	1.1	0.8	1.1	1.2	0.8	1.1
Baseline Anxiety	0.9	1.5	2.7	0.8	0.7	1.4	1.4	-1.1	-1.6
Tail length	0.1	0.3	0.5	0.2	0.5	0.5	0.7	-0.7	0.3
Length with tail	0.0	0.2	0.5	-0.2	-0.0	0.4	0.5	-0.7	-0.3
Length without tail	0.1	0.4	1.7	-0.4	-0.5	-0.0	-0.1	-0.6	-1.3
Times rat made contact with spout	0.3	0.3	0.8	-0.9	-0.2	-0.7	-0.5	-0.4	-0.1
Lifetime Intake	0.4	0.6	1.5	1.2	0.9	0.7	0.5	-0.2	0.6
Liver weight, left	2.2	3.8	4.8	2.2	2.0	2.0	1.9	-2.1	-1.4
Liver weight, right	1.8	3.2	5.0	1.3	1.4	1.7	1.6	-2.2	-2.2
Locomotor activity	0.1	0.2	0.7	-0.1	-0.8	0.2	0.3	0.1	-0.6
Locomotor testing distance	0.5	1.3	3.5	-1.4	-1.9	-0.9	-0.8	0.9	-0.2
Locomotor testing rearing	0.0	0.1	0.3	-0.5	-0.5	-0.3	-0.3	0.2	0.0
Locomotion in novel chamber	0.9	1.2	2.6	-1.1	-1.1	-1.5	-1.6	0.3	0.2
Locomotion in novel chamber post-restriction	0.1	0.3	1.0	0.5	0.6	-0.3	-0.3	-0.2	1.0
Fecal boli incidents, locomotor time 1	0.2	0.4	1.4	-0.0	0.2	-0.7	-0.5	0.5	1.2
Change in fecal boli incidents, locomotor task	0.5	0.5	0.9	0.8	0.0	0.9	0.8	-0.3	-0.8
Time >=10cm from walls, locomotor time 1	0.3	0.4	1.4	0.1	-0.8	-0.0	-0.3	1.2	0.3
Bouts of movement, locomotor time 1	0.6	0.8	2.9	-0.9	-0.6	-0.5	-0.5	-0.4	-1.7
Total resting periods, locomotor time 1	0.7	0.8	3.2	-0.9	-0.5	-0.3	-0.2	-0.4	-1.8
Rest time, locomotor task time 1	0.2	0.2	1.0	-0.1	-0.5	0.2	0.5	-0.1	-1.0
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.3	0.5	0.6	0.4	-0.2	0.3
Vertical activity count, locomotor time 1	0.0	0.2	0.4	0.2	-0.3	0.4	0.3	0.6	0.6
Time >=10cm from walls, locomotor time 2	1.1	3.0	4.4	1.9	1.5	2.1	1.8	-1.5	-1.5
Bouts of movement, locomotor time 2	0.4	1.4	2.7	-1.3	-1.6	-1.1	-1.4	0.9	-0.4
Total resting periods, locomotor time 2	0.3	1.4	2.4	-1.3	-1.5	-1.2	-1.3	1.0	-0.2
Rest time, locomotor task time 2	0.2	0.3	0.8	-0.3	-0.8	-0.4	0.1	0.9	-0.2
Distance moved, locomotor task time 2	2.0	2.7	4.5	1.2	1.5	2.0	1.5	-2.1	-1.2
Vertical activity count, locomotor time 2	0.5	1.1	1.9	0.9	0.4	1.4	0.8	-1.3	-1.1
Light reinforcement 1	0.2	0.8	2.9	0.6	0.5	0.5	0.5	-1.7	-0.9
Light reinforcement 2	0.3	0.7	1.4	1.1	0.5	0.6	0.7	-1.2	-0.7
Bone: marrow area	0.2	0.6	1.5	-1.1	-1.2	-0.7	-0.6	-0.1	-0.4
Bone: maximum diameter	0.8	1.6	2.3	-1.2	-1.1	-1.3	-1.3	1.2	1.5
Bone: maximum force	0.0	0.1	0.5	-0.2	-0.0	-0.2	-0.1	-0.7	0.2
Bone: maximum moment	0.2	0.4	0.8	-0.9	-0.7	-0.8	-0.6	-0.4	0.1
Mean time between licks in bursts	1.2	7.4	9.3	2.9	2.8	3.1	3.0	-2.5	-1.9
Mean num. licks in bursts	0.1	0.2	0.6	-0.3	-0.2	0.1	0.3	-0.8	-0.5
Cd content in liver	1.4	1.5	3.3	-1.5	-1.8	-1.2	-1.3	0.5	0.6
Co content in liver	1.2	1.4	4.1	0.1	0.1	0.4	0.2	-2.0	-2.0
Cu content in liver	0.7	0.9	1.5	0.8	1.2	0.8	0.8	-1.2	-0.6
Fe content in liver	2.0	2.5	9.5	0.1	0.2	0.9	0.7	-2.0	-3.1
K content in liver	2.5	2.4	3.2	1.4	1.4	1.8	1.6	-1.7	-1.4
Mg content in liver	0.3	0.4	1.0	-0.5	-0.4	-0.4	-0.4	0.6	1.0
Mn content in liver	0.2	0.2	0.6	-0.3	-0.1	-0.7	-0.8	0.0	0.3
Na content in liver	4.1	4.7	6.3	1.9	1.9	2.5	2.4	-2.5	-1.6
Rb content in liver	0.3	0.4	1.0	0.7	1.0	0.5	0.4	-0.7	-0.4
Se content in liver	0.6	0.8	3.1	0.0	-0.2	0.5	0.5	-1.0	-1.7
Sr content in liver	1.0	0.9	1.7	-1.0	-1.3	-1.0	-1.0	0.5	0.5
Zn content in liver	1.7	2.0	2.8	-1.6	-1.2	-1.4	-1.5	1.1	1.7
Bone: minimum diameter	1.2	2.3	4.2	-1.9	-2.1	-1.4	-1.3	1.5	0.4
Time in familiar zone, hab. session 1	2.1	2.3	3.1	1.7	1.7	1.3	1.2	-1.6	-1.5
Time in novel zone, hab. session 1	4.4	4.9	7.4	-2.4	-2.7	-2.1	-2.0	2.2	1.8
Total zone transitions, hab. session 1	0.5	0.7	2.1	0.9	1.4	0.8	0.7	-0.7	0.0
Total locomotion distance, hab. session 1	0.4	0.6	0.8	0.7	0.7	0.9	0.9	-0.7	-0.6
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.6	0.7	0.7	0.6	-0.5	-0.3
Time in familiar zone, hab. session 2	0.2	0.2	0.6	0.5	0.8	-0.1	-0.1	-0.7	-0.3
Time in novel zone, hab. session 2	0.5	0.6	1.2	-0.7	-1.1	-0.3	-0.4	1.0	0.7
Total zone transitions, hab. session 2	3.3	4.2	7.6	2.6	2.8	2.1	2.0	-1.6	0.1
Total locomotion distance, hab. session 2	2.5	3.3	4.7	2.2	2.1	2.2	2.0	-1.4	-0.4
Locomotion velocity, hab. session 2	2.2	2.9	4.4	2.1	2.1	2.0	1.9	-1.2	-0.1
Novel to familiar place preference ratio	0.6	0.8	1.7	-1.0	-1.3	-0.9	-0.8	0.6	0.4
Novelty place preference	0.3	0.4	1.2	-0.7	-1.1	-0.5	-0.5	0.3	0.1
Time in novel zone, NPP test	0.4	0.5	1.4	-0.8	-1.2	-0.6	-0.6	0.3	-0.0
Total zone transitions, NPP test	0.8	1.2	2.8	1.2	1.7	1.2	1.1	-0.9	0.1
Total locomotion distance, NPP test	0.6	0.9	1.6	1.0	0.9	1.3	1.2	-0.5	-0.1
Locomotion velocity, NPP test	0.5	0.8	1.4	1.0	0.9	1.2	1.1	-0.4	0.0
Intraocular pressure	0.1	0.1	0.3	0.6	-0.1	0.2	0.3	0.6	0.0
Delta distance traveled before/after self-admin	1.2	1.3	2.6	-0.7	-0.7	-0.9	-1.0	1.6	1.5
Delta ambulatory time before/after self-admin	0.7	1.2	3.1	-0.4	-0.5	-0.7	-0.8	1.7	1.7
Parametrial fat weight	4.2	9.9	16.8	-4.1	-4.1	-3.2	-3.0	2.3	1.2
Pavlov. Cond. lever latency	1.0	1.2	2.2	1.5	1.0	1.4	1.5	0.2	0.1
Pavlov. Cond. magazine entry latency	0.1	0.2	0.6	-0.3	0.1	-0.4	-0.5	-0.1	0.8
Pavlov. Cond. change in total contacts	1.0	1.1	1.8	-1.3	-1.1	-1.3	-1.3	0.2	0.4
Pavlov. Cond. index score	0.5	0.6	1.1	-1.1	-0.7	-1.0	-1.0	-0.2	0.0
Pavlov. Cond. latency score	0.6	0.7	1.3	-1.1	-0.7	-1.1	-1.1	-0.2	0.2
Pavlov. Cond. lever contacts	0.6	0.8	1.4	-1.1	-0.6	-1.2	-1.2	-0.3	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.3	-0.3	0.2	0.3	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	0.5	0.6	0.3	0.5	0.7	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.4	-1.2	-0.8	-1.1	-1.2	-0.0	0.2
Pavlov. Cond. response bias	0.3	0.4	0.8	-0.9	-0.3	-0.8	-0.9	-0.4	0.0
Pavlov. Cond. lever latency	2.1	2.9	4.3	1.6	1.8	1.7	1.6	-1.4	-2.1
Pavlov. Cond. magazine entry latency	1.8	2.5	3.4	-1.5	-1.5	-1.9	-1.8	1.4	1.5
Pavlov. Cond. change in total contacts	0.8	2.0	2.4	-1.3	-1.6	-1.4	-1.3	1.2	1.6
Pavlov. Cond. index score	1.2	1.9	2.4	-1.4	-1.5	-1.5	-1.4	1.0	1.3
Pavlov. Cond. latency score	1.0	1.6	2.0	-1.2	-1.4	-1.4	-1.3	0.9	1.2
Pavlov. Cond. lever contacts	2.1	3.1	4.5	-1.7	-1.8	-1.8	-1.7	1.5	2.1
Pavlov. Cond. magazine entry number	1.0	1.3	1.7	1.0	1.0	1.3	1.3	-1.0	-1.3
Pavlov. Cond. intertrial magazine entries	0.6	1.3	2.1	1.2	1.3	1.4	1.5	-0.5	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.3	2.0	2.6	-1.4	-1.6	-1.5	-1.5	1.1	1.3
Pavlov. Cond. response bias	2.1	3.0	4.3	-1.7	-1.7	-1.8	-1.7	1.5	2.1
Time in closed arm before self-admin	0.3	0.6	2.4	0.4	0.5	-0.4	-0.4	0.6	1.6
Time in closed arm after self-admin	0.1	0.1	0.5	0.3	0.7	0.0	-0.0	-0.0	-0.1
Time in open arm before self-admin	0.5	0.6	2.8	-0.7	-0.5	0.3	0.2	-0.3	-1.7
Time in open arm after self-admin	2.1	2.3	5.4	-1.6	-2.3	-1.3	-1.3	1.4	0.5
Bone: periosteal estimation	0.3	0.8	1.9	-1.2	-1.4	-0.9	-0.8	0.2	0.1
Bone: periosteal perimeter	0.9	1.9	2.6	-1.4	-1.3	-1.5	-1.4	1.0	1.6
Bone: post-yield work	1.2	2.0	3.6	-1.4	-1.3	-1.9	-1.7	0.3	1.3
Progressive ratio test 1 active lever presses	0.9	1.5	4.0	2.0	1.5	1.0	0.8	-0.7	0.6
Progressive ratio test 1 breakpoint	1.1	1.8	4.7	2.2	1.7	1.2	1.0	-0.9	0.5
Progressive ratio test 1 inactive lever presses	0.8	2.1	4.7	2.2	1.6	1.6	1.3	-1.2	-0.2
Progressive ratio test 2 active lever presses	0.3	0.4	1.6	0.4	0.3	-0.4	-0.5	0.3	1.3
Progressive ratio test 2 breakpoint	0.4	0.4	1.7	0.6	0.5	-0.3	-0.4	0.2	1.3
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.2	0.2	0.2	0.1	-0.0	0.0	0.4
Incentive Sensitization - Responses	0.2	0.6	1.2	-0.5	-0.3	-0.9	-0.9	0.6	1.1
Incentive Sensitization - Breakpoint	0.4	0.8	1.5	-0.7	-0.4	-1.0	-1.1	0.8	1.2
Sum of active levers in priming session hrs 5-6	3.5	3.3	8.3	1.2	0.8	1.5	1.6	-2.2	-2.9
Progressive ratio	0.1	0.2	0.8	0.4	0.5	0.1	0.1	0.1	0.9
Food seeking constrained by brief footshock	4.3	5.4	7.4	2.6	2.1	2.7	2.7	-2.2	-1.3
Seeking ratio, punishment vs. effort	0.8	1.7	2.6	1.1	1.0	1.2	1.2	-1.6	-1.6
Retroperitoneal fat weight	0.3	1.3	2.2	-1.3	-1.5	-1.3	-1.2	0.8	0.3
Reaction time number correct	0.1	0.3	1.0	0.3	-0.2	0.0	0.1	0.6	1.0
Reaction time mean minus median	0.3	2.1	3.3	-1.1	-1.2	-1.8	-1.8	1.2	1.3
Reaction time mean minus median AUC	0.1	0.6	1.2	-0.4	-0.5	-1.0	-1.1	0.8	0.8
Reaction time num false alarms	0.2	0.3	0.7	-0.5	-0.5	-0.3	-0.4	0.8	0.7
Reaction time num false alarms AUC	0.4	0.9	1.3	-1.1	-1.0	-0.8	-0.8	1.1	0.9
Reaction time trials correct on left	0.1	0.3	1.0	0.3	-0.2	0.0	0.1	0.6	1.0
Reaction time trials on left	0.1	0.3	1.0	0.2	-0.2	-0.1	-0.0	0.7	1.0
Reaction time mean	0.7	1.4	2.7	-0.6	-1.0	-1.6	-1.6	1.2	0.8
Reaction time mean AUC	0.3	0.8	1.8	-0.2	-0.6	-1.3	-1.3	0.9	0.5
Median of all reaction times	0.7	1.1	2.0	-0.3	-0.9	-1.3	-1.4	1.2	0.7
Reaction time omissions	1.2	2.0	3.8	-1.4	-1.2	-1.8	-1.9	0.9	0.9
Reaction time false alarm rate	0.7	0.9	1.8	-1.3	-1.0	-0.9	-1.0	0.9	0.5
Reaction time premature initiation rate	0.3	0.5	0.9	-0.2	0.8	0.8	0.6	-0.9	-0.7
Reaction time premature initiations	0.2	0.5	0.8	0.2	0.9	0.9	0.8	-0.8	-0.3
Std. dev. reaction times	1.0	3.4	5.7	-1.7	-1.8	-2.3	-2.4	1.6	1.0
Reaction time trials completed	0.1	0.3	1.0	0.2	-0.2	-0.1	-0.0	0.7	1.0
Reaction time trials AUC	0.1	0.3	1.1	0.1	-0.3	-0.1	-0.0	0.7	1.0
Run reversals in cocaine runway, females	0.4	0.4	2.0	-0.3	-0.0	0.4	0.4	-0.5	-1.4
Run reversals in cocaine runway, males	0.5	0.6	1.0	-0.8	-0.9	-1.0	-1.0	0.3	0.1
Latency to leave start box in cocaine runway	0.5	0.7	1.2	1.0	0.5	0.8	0.9	-1.1	-0.5
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	-0.1	0.3
Latency to leave start box in cocaine runway, M	1.9	1.8	2.5	1.4	1.0	1.3	1.3	-1.6	-1.4
Std. dev. time between licks in bursts	0.6	1.1	3.8	0.6	0.1	0.8	0.9	-0.8	-2.0
Total sessions with >9 infusions	0.6	0.7	1.6	1.2	0.9	1.0	0.8	-0.1	0.6
Short access day 1 total inactive lever presses	0.1	0.3	0.8	0.1	0.3	0.2	0.3	-0.8	-0.9
Short access day 10 total inactive lever presses	0.2	1.5	5.1	-1.3	-1.4	-0.1	-0.1	-0.4	-2.3
Short access day 1 total infusions	0.3	0.7	1.5	1.1	0.3	1.2	1.1	-0.1	-0.1
Short access day 10 total infusions	0.3	0.5	1.1	1.1	1.0	0.3	0.1	-0.9	0.2
Short access total infusions	0.2	0.3	0.8	0.9	0.5	0.5	0.3	-0.0	0.6
Short access day 1 locomotion	0.1	0.1	0.5	0.0	-0.1	-0.0	-0.1	0.3	0.7
Short access day 10 total locomotion	0.2	0.8	1.8	-1.3	-0.3	-1.3	-1.2	-0.0	0.3
Short access total locomotion	0.2	0.3	1.1	0.2	0.5	-0.1	-0.2	0.1	1.1
One hour access (0.3 mA shock)	1.3	1.6	3.4	-0.2	0.2	-1.6	-1.8	0.4	1.8
Compulsive drug intake	1.5	2.2	3.4	-1.6	-1.8	-1.4	-1.5	1.6	0.6
One hour access (shock baseline)	0.3	0.8	2.2	1.2	1.5	0.2	0.1	-0.6	0.8
Social response proportion	0.8	1.0	2.2	-0.6	-0.5	-1.0	-1.0	1.1	1.5
Social responses	0.2	0.2	0.5	-0.1	0.5	-0.3	-0.4	-0.7	0.4
Social time	0.3	0.4	1.0	-0.3	-0.4	-1.0	-0.9	0.2	0.6
Soleus weight	0.1	0.3	0.5	0.2	0.7	0.0	-0.2	-0.7	0.7
Bone: stiffness	0.0	0.1	0.3	-0.0	-0.1	-0.0	0.1	-0.6	-0.1
Tibialis anterior weight	5.6	19.2	28.3	-5.3	-5.1	-4.8	-4.7	3.5	2.0
Time to tail flick, vehicle, before self-admin	1.5	1.9	2.7	-1.5	-1.4	-1.6	-1.7	1.2	0.3
Time to tail flick, vehicle, after self-admin	0.6	1.3	3.3	-0.7	-1.1	-1.0	-0.9	1.8	1.0
Time to tail flick, test, before self-admin	0.1	0.2	0.4	0.5	0.2	0.6	0.5	0.2	-0.2
Time to tail flick, test, after self-admin	0.6	0.6	1.3	0.9	0.5	1.0	1.1	-0.3	-0.5
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.5	1.2	0.9	1.0	1.0	-0.2	0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.6	-0.7	-0.4	-0.1	0.4	0.4
Tibia length	2.8	7.8	11.4	2.8	3.0	2.9	2.8	-3.4	-1.5
Ambulatory time before self-admin	0.2	0.5	1.9	-0.1	-0.4	0.0	0.1	-0.8	-1.4
Ambulatory time after self-admin	0.8	1.2	1.9	-0.8	-1.0	-1.3	-1.4	1.1	1.0
Bone: tissue strength	0.9	0.9	2.0	-0.8	-0.5	-1.1	-1.0	0.6	1.4
Total heroin consumption	0.7	0.8	1.5	1.2	1.1	0.6	0.6	-1.1	-0.5
Bone: trabecular number	0.3	0.5	1.0	0.5	0.3	0.9	1.0	-0.5	-0.7
Bone: trabecular spacing	0.0	0.1	0.2	0.0	0.3	-0.3	-0.3	-0.4	-0.1
Bone: trabecular thickness	0.2	0.3	0.5	0.7	0.4	0.7	0.7	0.0	0.2
Bone: trabecular tissue density	7.9	13.7	20.5	4.4	4.5	4.1	3.9	-3.2	-0.5
Water consumed over 24 hours	0.2	0.5	1.3	-0.4	0.1	-0.3	-0.3	-1.1	-1.0
Number of responses in last shaping day	0.3	0.4	1.9	-0.0	-0.1	-0.1	-0.2	-0.8	-1.4