LOC102547621

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC102547621	0.06	0.05	7.6e-03	0.06	0.04	0.05	0.05	1.7e-03	5.3e-03	3.0e-03	2.3e-03
2	Liver	gene expression	LOC102547621	0.11	0.06	2.4e-15	0.14	0.13	0.13	0.14	4.0e-15	1.4e-14	2.7e-14	6.1e-15
3	OFC	gene expression	LOC102547621	0.19	0.14	2.8e-03	0.03	0.06	0.06	0.03	7.0e-02	1.2e-02	1.4e-02	5.4e-02
4	PL	gene expression	LOC102547621	0.15	0.08	0.0e+00	0.13	0.15	0.14	0.14	1.9e-14	8.1e-16	1.3e-15	2.6e-15
5	Adipose	gene expression	LOC102547621	0.05	0.03	7.5e-06	0.02	0.04	0.04	0.04	2.3e-03	1.6e-05	1.7e-05	7.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.9	1.5	2.1	1.3	1.5	-0.5	-1.5	-1.1
Area under the delay curve	0.7	0.8	1.2	-0.6	-1.0	-0.1	1.1	1.1
BMI with tail	1.6	5.1	7.7	2.8	2.4	-1.1	-2.7	-1.9
BMI without tail	3.6	7.5	16.5	4.1	2.7	-2.8	-2.3	-0.9
Body weight	2.2	9.0	18.4	4.3	3.2	-2.8	-2.7	-1.3
Weight adjusted by age	0.7	0.8	1.5	0.5	-0.4	-1.2	0.9	1.2
Bone surface	0.5	0.8	1.4	1.2	1.0	-1.1	-0.5	-0.1
Bone volume	0.5	0.8	1.4	1.1	1.2	-0.7	-0.9	-0.5
Breakpoint value in progressive ratio session	1.7	1.9	4.0	-0.2	-1.2	-0.9	1.8	2.0
Number of licking bursts	4.1	4.8	7.8	2.5	2.8	-1.5	-2.3	-1.6
Context. condit. distance diff. score	0.1	0.1	0.3	-0.5	-0.0	0.5	0.0	-0.2
Locomotion velocity, session 1	4.1	4.4	8.3	1.2	-0.6	-2.8	2.0	2.9
Locomotion distance, session 1	1.1	1.5	3.0	0.9	-0.3	-1.7	1.0	1.6
Locomotion velocity, session 2	1.6	1.9	2.6	1.5	1.6	-0.6	-1.6	-1.2
Locomotion distance, session 2	1.5	2.1	4.6	2.0	1.1	-2.2	-0.4	0.5
Locomotion velocity, session 3	0.8	0.9	1.8	0.4	-0.1	-1.2	1.0	1.3
Locomotion distance, session 3	1.6	1.7	3.5	1.9	1.2	-1.8	-0.4	0.3
Stereotopy head waving bouts, day 3	0.7	0.8	1.6	-0.0	0.3	-0.9	1.2	1.3
Stereotopy head waving duration, day 3	0.3	0.4	0.9	-0.5	0.2	-0.2	1.0	0.8
Locomotion velocity, session 7	0.0	0.0	0.1	-0.3	0.1	0.2	0.1	0.0
Locomotion distance, session 7	0.2	0.2	0.5	0.5	0.4	-0.7	-0.1	0.2
Stereotopy head waving bouts, day 7	1.8	2.0	3.7	1.8	1.9	-1.4	-0.9	-0.4
Stereotopy head waving duration, day 7	0.6	0.7	1.6	1.1	1.2	-1.0	-0.3	-0.0
Locomotion velocity, session 8	0.5	0.7	1.3	0.3	0.0	-1.1	0.8	1.1
Locomotion distance, session 8	0.4	0.6	1.4	0.6	0.1	-1.2	0.5	0.9
Degree of sensitization distance	0.6	0.6	1.6	-1.3	-0.5	1.0	0.4	-0.0
Degree of sensitization stereotypy	1.0	1.1	2.0	1.3	1.4	-0.9	-0.8	-0.5
Conditioned locomotion	0.5	0.6	1.3	0.0	-0.2	-0.8	1.0	1.2
Cocaine response after cond. corrected	2.6	3.0	5.4	-1.1	-1.7	-0.5	2.3	2.3
Cocaine response after cond. not corrected	2.7	2.9	5.6	-0.8	-1.5	-0.8	2.3	2.4
Cocaine response before conditioning	0.8	1.0	1.9	1.1	1.4	-0.5	-1.0	-0.8
Saline control response	1.2	1.5	3.6	1.5	1.1	-1.9	0.2	0.8
Bone: connectivity density	0.5	0.7	1.4	0.7	0.9	-0.1	-1.2	-1.0
Bone: cortical apparent density	1.0	1.3	2.5	-0.4	0.5	1.4	-1.2	-1.6
Bone: cortical area	1.9	2.9	4.1	1.9	2.0	-0.7	-2.0	-1.6
Bone: cortical porosity	0.4	0.5	1.0	-0.9	-1.0	0.6	0.5	0.2
Bone: cortical porosity	0.0	0.0	0.1	-0.1	-0.4	0.1	0.1	0.0
Bone: cortical thickness	1.2	2.0	3.7	0.9	1.3	0.3	-1.9	-1.8
Bone: cortical thickness	0.2	0.3	0.6	-0.3	-0.0	0.8	-0.4	-0.6
Bone: cortical tissue density	0.8	1.1	2.0	-0.5	0.4	1.3	-1.0	-1.4
Condit. Reinf. active minus inactive responses	0.5	0.5	0.9	0.7	1.0	-0.3	-0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.8	-0.9	-0.5	0.9	0.3	-0.1
Condit. Reinf. active responses	2.3	2.9	5.3	1.8	2.3	-1.0	-1.8	-1.3
Condit. Reinf. inactive responses	2.9	3.5	5.6	2.0	2.4	-0.8	-2.1	-1.6
Incentive salience index mean	2.9	3.5	5.8	2.4	2.3	-1.8	-1.6	-0.8
Condit. Reinf. lever presses	6.7	8.9	16.8	4.1	3.3	-3.5	-2.0	-0.5
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	0.9	0.7	-0.5	-0.8	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.2	-0.1	0.1	-0.4	-0.4
Condit. Reinf. active responses	1.5	2.1	3.5	1.9	1.7	-1.2	-1.4	-0.8
Condit. Reinf. inactive responses	2.8	3.5	5.4	2.0	2.3	-0.8	-2.2	-1.7
Condit. Reinf. lever presses	2.5	3.4	5.4	1.6	2.3	-0.2	-2.3	-2.0
Condit. Reinf. lever reinforcers received	1.8	2.5	4.0	2.0	1.9	-1.3	-1.6	-0.9
Conditioned reinforcement - actives	0.4	0.4	1.2	-0.1	1.1	-0.2	-0.7	-0.6
Conditioned reinforcement - inactives	0.1	0.2	0.6	-0.3	0.8	-0.3	-0.1	-0.1
Conditioned locomotion	0.2	0.3	0.5	0.4	0.7	-0.6	-0.5	-0.2
Patch foraging indifference point 0 sec	1.9	3.1	5.8	0.9	-0.5	-2.4	1.7	2.4
Patch foraging indifference point AUC	4.4	5.0	10.9	3.3	2.2	-2.4	-1.8	-0.7
Delay disc. indifference point, 0s delay	1.1	1.2	1.9	-1.1	-1.2	0.3	1.4	1.1
Delay disc. indifference point, 16s delay	2.0	2.0	3.5	-0.7	-1.6	-0.5	1.8	1.9
Delay disc. indifference point, 2s delay	0.3	0.3	0.5	-0.1	0.7	0.4	-0.6	-0.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.3	-0.7	0.3	0.3	0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.4	-0.4	0.2	0.2	0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.1	-0.2	-0.2	0.1	0.2
Indifference point function ln k	1.3	1.8	3.9	-2.0	-1.1	1.3	1.3	0.6
Indifference point function log k	1.3	1.8	3.9	-2.0	-1.1	1.3	1.3	0.6
Patch foraging total patch changes 0 sec	1.7	2.7	6.3	1.2	-0.1	-2.5	1.3	2.0
Patch foraging total patch changes 12 sec	1.1	1.4	3.4	1.9	0.8	-1.3	-1.0	-0.4
Patch foraging total patch changes 18 sec	0.5	0.6	1.6	1.1	0.4	-1.3	-0.0	0.5
Patch foraging total patch changes 24 sec	1.4	1.7	3.8	1.9	0.9	-1.9	-0.4	0.4
Patch foraging total patch changes 6 sec	1.9	2.9	7.5	2.3	0.6	-2.7	0.1	1.1
Patch foraging time to switch 0 sec	1.6	2.5	5.2	-2.3	-1.4	2.2	0.5	-0.3
Patch foraging water rate 0 sec	1.2	1.9	4.7	1.9	0.7	-2.2	0.0	0.8
Patch foraging water rate 12 sec	0.1	0.2	0.4	0.3	0.4	-0.6	0.4	0.5
Patch foraging water rate 18 sec	0.4	0.5	0.9	0.5	0.7	0.1	-0.9	-0.9
Patch foraging water rate 24 sec	0.5	0.7	1.5	-0.3	0.5	1.1	-0.9	-1.2
Patch foraging water rate 6 sec	0.8	1.2	2.7	1.2	1.6	-0.9	-0.8	-0.5
Seeking ratio, delayed vs. immediate footshock	2.6	2.9	5.0	2.2	1.9	-1.2	-1.8	-1.2
Distance traveled before self-admin	4.2	4.5	8.5	2.9	2.4	-2.6	-1.1	-0.1
Distance traveled after self-admin	1.7	1.9	4.6	1.0	2.1	-0.4	-1.5	-1.3
Extensor digitorum longus weight	3.4	13.4	22.2	4.7	4.6	-3.4	-3.1	-1.6
Bone: elastic displacement	3.2	3.7	6.5	-2.6	-2.2	2.5	1.0	-0.0
Bone: elastic work	2.4	3.1	8.1	-1.9	-0.9	2.9	-0.7	-1.6
Bone: endosteal estimation	0.9	1.9	3.6	1.8	1.6	-1.9	-0.3	0.4
Bone: endosteal perimeter	1.0	2.2	4.6	1.9	1.5	-2.1	-0.0	0.7
Epididymis fat weight	0.4	0.9	2.0	1.4	0.8	-1.3	-0.5	0.0
Delta time in closed arm before/after self-admin	2.0	1.9	3.4	1.4	1.3	-0.1	-1.9	-1.6
Delta time in open arm before/after self-admin	0.5	0.5	0.9	-0.5	-0.5	-0.2	0.9	0.9
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.3	0.1	0.3	-0.0	-0.1
Delay discount exponential model param	0.6	0.7	1.1	0.5	1.0	0.1	-1.0	-1.0
Extinction: sum of active levers before priming	1.1	1.1	2.3	-1.5	-1.0	0.9	1.0	0.6
Active lever presses in extinction session 6	1.1	1.1	2.4	-0.9	-1.5	0.3	1.1	1.0
Bone: final force	0.9	1.5	2.5	1.5	1.6	-1.0	-1.2	-0.7
Bone: final moment	0.8	1.3	2.2	1.2	1.5	-0.6	-1.3	-0.9
Food consumed during 24 hour testing period	0.6	0.8	1.7	1.2	0.7	-1.3	-0.4	0.2
Glucose	0.6	0.9	2.0	1.4	0.7	-1.1	-0.7	-0.2
Heart weight	0.4	0.6	1.5	1.2	0.4	-1.1	-0.3	0.2
Delay discount hyperbolic model param	0.6	0.6	1.0	0.5	0.9	0.1	-0.9	-1.0
Intermittent access intake day 1-15 change	1.4	1.4	2.6	0.7	1.1	0.3	-1.6	-1.5
Intermittent access intake escalation	1.2	1.2	2.4	1.1	1.0	-0.1	-1.5	-1.3
Intermittent access intake escalation 2	2.4	2.4	4.4	1.0	1.6	0.3	-2.1	-2.0
Intermitt. access day 1 inactive lever presses	0.4	0.5	1.2	1.1	0.5	-0.8	-0.5	-0.1
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.6	0.6	0.0	-0.8	0.3	0.5
Intermitt. access escalation Index	1.0	0.9	2.2	1.5	0.6	-1.3	-0.1	0.4
Intermittent access day 1 total infusions	1.0	1.1	2.0	-0.8	-1.0	-0.3	1.4	1.4
Intermittent access day 15 total infusions	0.2	0.2	0.3	0.5	0.5	-0.5	-0.5	-0.2
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.3	0.7	1.2	-0.8	-0.7	-0.3
Intermittent access total infusions	0.3	0.4	0.9	0.7	0.7	-0.9	-0.3	0.1
Intermittent access day 1 locomotion	1.7	1.8	2.8	-1.2	-1.7	0.2	1.6	1.5
Intermittent access day 15 total locomotion	0.8	0.8	1.5	-1.1	-1.2	0.4	0.9	0.7
Intermittent access total locomotion	0.4	0.5	1.1	-1.1	-0.7	0.8	0.3	0.0
Intermittent access standard deviation	0.4	0.5	0.9	0.6	0.7	-0.2	-0.9	-0.7
Left kidney weight	0.4	1.2	2.9	1.6	0.4	-1.7	0.1	0.7
Right kidney weight	0.2	0.4	0.8	0.6	-0.3	-0.9	0.6	0.8
Cocaine induced anxiety	0.5	0.6	1.4	-1.2	-0.6	0.5	0.8	0.5
Post-drug Anxiety	0.3	0.4	0.7	0.8	0.7	-0.7	-0.4	-0.1
Baseline Anxiety	0.9	1.0	1.6	1.2	0.8	-0.2	-1.3	-1.0
Tail length	1.8	5.4	11.5	3.4	2.4	-2.7	-1.5	-0.3
Length with tail	0.7	2.5	5.0	2.2	1.4	-2.2	-0.4	0.5
Length without tail	0.3	0.7	1.0	-1.0	-0.9	0.3	1.0	0.8
Times rat made contact with spout	0.7	0.8	1.4	0.6	1.2	-0.0	-1.0	-1.0
Lifetime Intake	0.7	0.8	2.5	0.8	0.7	-1.6	0.2	0.8
Liver weight, left	0.3	0.5	1.1	1.1	0.7	-0.8	-0.6	-0.3
Liver weight, right	0.0	0.1	0.1	-0.2	0.1	-0.2	0.4	0.4
Locomotor activity	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.2	-0.1
Locomotor testing distance	0.3	0.4	0.9	0.2	-0.2	-0.8	0.7	0.9
Locomotor testing rearing	0.7	1.0	1.9	1.2	1.3	-1.4	-0.6	-0.0
Locomotion in novel chamber	0.2	0.3	0.5	-0.5	-0.2	0.7	-0.4	-0.6
Locomotion in novel chamber post-restriction	2.2	2.6	4.6	0.8	1.8	0.3	-2.2	-2.1
Fecal boli incidents, locomotor time 1	0.8	0.9	1.9	-1.0	-1.4	1.0	0.6	0.2
Change in fecal boli incidents, locomotor task	0.9	0.9	2.3	1.1	0.7	-1.5	0.0	0.6
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	0.4	-0.1	-0.8	0.7	0.9
Bouts of movement, locomotor time 1	1.0	1.1	2.8	-1.7	-0.8	1.3	0.7	0.1
Total resting periods, locomotor time 1	1.5	1.6	3.8	-2.0	-0.8	1.8	0.5	-0.3
Rest time, locomotor task time 1	2.6	2.9	7.1	-1.8	-0.3	2.7	-0.9	-1.8
Distance moved, locomotor task time 1	2.1	2.3	5.9	1.9	1.0	-2.4	0.2	1.1
Vertical activity count, locomotor time 1	2.1	2.2	5.2	1.6	0.6	-2.3	0.7	1.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.5	-0.1	-0.5	0.1	0.2
Bouts of movement, locomotor time 2	0.5	0.6	1.2	0.8	1.1	-0.4	-0.8	-0.5
Total resting periods, locomotor time 2	0.3	0.3	0.7	0.4	0.9	-0.1	-0.6	-0.5
Rest time, locomotor task time 2	0.6	0.7	1.8	-1.4	-0.3	1.2	0.2	-0.4
Distance moved, locomotor task time 2	0.4	0.5	0.9	0.8	0.6	-0.1	-1.0	-0.8
Vertical activity count, locomotor time 2	0.4	0.5	1.3	1.1	0.4	-0.9	-0.2	0.2
Light reinforcement 1	2.3	4.2	10.4	2.2	0.4	-3.2	1.0	2.1
Light reinforcement 2	3.1	4.2	7.8	1.1	-0.6	-2.8	2.0	2.8
Bone: marrow area	0.9	2.0	3.5	1.9	1.7	-1.8	-0.5	0.2
Bone: maximum diameter	1.7	3.1	5.2	2.2	2.3	-1.4	-1.6	-1.0
Bone: maximum force	2.2	3.8	6.2	2.3	2.5	-1.4	-2.0	-1.3
Bone: maximum moment	1.8	3.1	5.1	1.9	2.3	-1.0	-1.9	-1.4
Mean time between licks in bursts	0.2	0.2	0.6	-0.7	-0.2	0.5	0.4	0.2
Mean num. licks in bursts	1.6	2.0	3.4	-1.8	-1.6	1.4	1.2	0.6
Cd content in liver	1.1	1.2	1.9	0.8	1.3	-0.0	-1.4	-1.2
Co content in liver	0.9	1.1	1.8	-1.0	-1.1	0.2	1.4	1.1
Cu content in liver	0.6	0.7	1.9	-1.2	-0.2	1.4	0.0	-0.5
Fe content in liver	1.3	1.6	3.0	0.7	0.1	-1.7	1.2	1.7
K content in liver	0.8	0.8	1.4	-0.2	-1.2	-0.3	1.0	1.1
Mg content in liver	0.8	0.8	1.5	-0.8	-1.2	0.3	1.0	0.8
Mn content in liver	0.5	0.6	1.2	0.2	0.8	0.4	-0.9	-1.1
Na content in liver	0.7	0.7	1.3	-1.1	-0.9	0.8	0.7	0.3
Rb content in liver	3.1	3.9	6.6	-2.3	-2.6	1.2	2.0	1.4
Se content in liver	1.7	2.1	3.3	1.4	1.7	-0.4	-1.8	-1.5
Sr content in liver	0.4	0.4	0.8	0.7	0.9	-0.3	-0.6	-0.4
Zn content in liver	0.4	0.4	0.8	-0.0	0.6	0.6	-0.8	-0.9
Bone: minimum diameter	0.0	0.1	0.2	-0.2	0.1	0.5	-0.1	-0.3
Time in familiar zone, hab. session 1	2.6	2.5	4.7	-1.0	0.6	2.2	-1.4	-2.1
Time in novel zone, hab. session 1	3.2	3.1	6.8	-0.8	-1.1	-0.9	2.5	2.6
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.0	-0.4	0.0	-0.0	0.0
Total locomotion distance, hab. session 1	0.7	1.1	2.3	0.4	0.4	0.6	-1.5	-1.5
Locomotion velocity, hab. session 1	1.2	1.7	3.6	1.3	0.8	-0.1	-1.9	-1.6
Time in familiar zone, hab. session 2	1.2	1.2	3.1	-1.1	-0.2	1.7	-0.6	-1.2
Time in novel zone, hab. session 2	2.1	2.1	4.3	-0.8	-1.0	-0.6	2.1	2.0
Total zone transitions, hab. session 2	0.6	0.7	1.9	1.0	-0.1	-1.4	0.2	0.8
Total locomotion distance, hab. session 2	0.4	0.5	1.1	1.1	0.5	-0.7	-0.7	-0.3
Locomotion velocity, hab. session 2	0.5	0.7	1.5	1.2	0.5	-0.8	-0.9	-0.5
Novel to familiar place preference ratio	3.3	3.4	5.8	-1.8	-1.9	0.2	2.4	2.1
Novelty place preference	4.0	4.1	6.3	-2.1	-2.3	0.6	2.5	2.0
Time in novel zone, NPP test	4.7	4.8	7.5	-2.4	-2.4	0.7	2.7	2.2
Total zone transitions, NPP test	0.7	1.0	2.7	1.3	0.1	-1.6	0.3	0.9
Total locomotion distance, NPP test	1.1	1.5	3.6	1.8	0.3	-1.9	-0.3	0.5
Locomotion velocity, NPP test	1.2	1.7	4.2	2.0	0.4	-1.9	-0.7	0.2
Intraocular pressure	1.6	2.2	4.2	2.0	1.6	-1.9	-0.6	0.1
Delta distance traveled before/after self-admin	0.3	0.3	0.9	-1.0	-0.1	0.8	-0.0	-0.4
Delta ambulatory time before/after self-admin	0.8	0.9	2.4	-1.6	-0.5	1.3	0.2	-0.3
Parametrial fat weight	0.2	0.4	1.1	1.0	-0.0	-0.9	0.0	0.4
Pavlov. Cond. lever latency	5.3	6.7	11.4	-3.4	-3.2	2.7	2.0	0.9
Pavlov. Cond. magazine entry latency	0.5	0.6	1.6	0.7	1.3	-0.4	-0.7	-0.5
Pavlov. Cond. change in total contacts	2.0	2.1	3.7	1.9	1.7	-1.6	-1.0	-0.4
Pavlov. Cond. index score	2.5	3.2	5.8	2.1	2.4	-1.5	-1.6	-1.0
Pavlov. Cond. latency score	2.3	3.0	5.4	2.1	2.3	-1.4	-1.5	-0.9
Pavlov. Cond. lever contacts	4.0	4.7	7.9	2.7	2.8	-2.1	-1.7	-0.9
Pavlov. Cond. magazine entry number	0.8	0.9	1.9	-1.1	-1.4	0.6	0.9	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.5	0.6	-0.2	-0.6	-0.4
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.1	5.6	2.0	2.4	-1.1	-1.8	-1.2
Pavlov. Cond. response bias	2.5	3.0	5.4	2.1	2.3	-1.5	-1.5	-0.8
Pavlov. Cond. lever latency	3.7	5.0	10.6	-1.7	-3.3	0.2	2.5	2.2
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	-0.7	0.7	0.8	-0.1	-0.4
Pavlov. Cond. change in total contacts	2.4	3.4	5.5	0.7	2.3	0.9	-2.2	-2.3
Pavlov. Cond. index score	1.4	1.8	3.8	0.3	1.9	0.8	-1.4	-1.6
Pavlov. Cond. latency score	1.8	2.2	4.5	0.4	2.1	0.8	-1.6	-1.8
Pavlov. Cond. lever contacts	1.9	2.7	6.3	1.2	2.5	-0.1	-1.7	-1.6
Pavlov. Cond. magazine entry number	1.4	1.7	2.8	0.1	-1.6	-1.1	1.4	1.7
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	0.7	-0.5	-0.8	-0.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	3.7	0.2	1.9	0.8	-1.4	-1.6
Pavlov. Cond. response bias	1.4	1.9	4.3	0.7	2.1	0.3	-1.5	-1.5
Time in closed arm before self-admin	2.3	2.6	4.6	-2.0	-2.1	1.4	1.4	0.8
Time in closed arm after self-admin	0.3	0.3	0.6	-0.5	-0.7	0.8	-0.1	-0.3
Time in open arm before self-admin	1.9	2.1	4.2	1.9	1.5	-2.1	-0.4	0.3
Time in open arm after self-admin	1.1	1.2	2.7	1.4	1.1	-1.6	-0.0	0.5
Bone: periosteal estimation	1.2	2.5	4.4	2.1	2.0	-1.5	-1.2	-0.5
Bone: periosteal perimeter	0.6	0.9	2.0	1.2	0.9	-1.4	0.0	0.5
Bone: post-yield work	1.1	1.5	2.9	1.6	1.4	-1.7	-0.4	0.2
Progressive ratio test 1 active lever presses	0.5	0.5	1.2	0.4	0.6	-1.1	0.4	0.7
Progressive ratio test 1 breakpoint	0.6	0.6	1.5	0.5	0.8	-1.2	0.3	0.7
Progressive ratio test 1 inactive lever presses	1.5	1.6	3.9	1.0	0.5	-2.0	0.9	1.5
Progressive ratio test 2 active lever presses	0.6	0.7	1.4	-0.1	0.1	-1.1	0.9	1.2
Progressive ratio test 2 breakpoint	0.6	0.7	1.4	-0.3	-0.1	-0.9	1.0	1.2
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.8	0.4	0.7	-0.9	-0.2	0.2
Incentive Sensitization - Responses	0.2	0.2	0.6	0.0	0.4	-0.8	0.3	0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.1	0.3	-0.6	0.4	0.5
Sum of active levers in priming session hrs 5-6	3.6	3.5	5.3	-1.9	-2.3	0.6	2.2	1.8
Progressive ratio	0.2	0.2	0.5	-0.1	-0.7	-0.1	0.4	0.5
Food seeking constrained by brief footshock	4.9	6.1	11.8	3.4	2.4	-3.4	-1.0	0.3
Seeking ratio, punishment vs. effort	1.6	2.0	3.8	1.6	2.0	-1.5	-1.0	-0.4
Retroperitoneal fat weight	0.1	0.2	0.5	-0.4	-0.4	0.7	-0.1	-0.3
Reaction time number correct	0.2	0.3	0.6	0.3	-0.2	-0.7	0.4	0.7
Reaction time mean minus median	2.4	3.2	6.8	0.1	1.3	1.5	-2.3	-2.6
Reaction time mean minus median AUC	2.1	2.7	5.2	0.6	1.6	0.8	-2.2	-2.3
Reaction time num false alarms	0.4	0.5	0.9	-0.1	0.7	0.7	-0.7	-1.0
Reaction time num false alarms AUC	0.4	0.5	1.1	0.6	1.0	-0.1	-0.7	-0.7
Reaction time trials correct on left	0.2	0.3	0.6	0.3	-0.2	-0.7	0.4	0.7
Reaction time trials on left	0.2	0.3	0.5	0.2	-0.3	-0.6	0.5	0.7
Reaction time mean	1.5	2.2	5.5	-1.6	-0.0	2.3	-0.7	-1.5
Reaction time mean AUC	1.9	2.5	6.4	-1.8	0.1	2.5	-0.7	-1.6
Median of all reaction times	1.5	2.1	5.1	-2.1	-0.7	2.3	0.3	-0.6
Reaction time omissions	0.6	0.8	1.9	-1.4	-0.5	1.3	0.6	0.0
Reaction time false alarm rate	0.3	0.4	0.8	-0.2	0.6	0.8	-0.6	-0.9
Reaction time premature initiation rate	1.4	1.9	4.0	-1.7	-1.5	2.0	0.4	-0.3
Reaction time premature initiations	0.9	1.3	2.3	-1.3	-1.5	1.4	0.6	0.0
Std. dev. reaction times	1.9	2.7	5.2	-0.6	0.7	2.0	-1.7	-2.3
Reaction time trials completed	0.2	0.3	0.5	0.2	-0.3	-0.6	0.5	0.7
Reaction time trials AUC	0.2	0.3	0.5	0.2	-0.3	-0.6	0.5	0.7
Run reversals in cocaine runway, females	0.2	0.2	0.5	-0.1	-0.3	0.7	-0.5	-0.6
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.1	0.1	0.3	-0.1	-0.2
Latency to leave start box in cocaine runway	0.8	0.8	1.4	0.9	1.2	-0.4	-1.0	-0.8
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.0	-0.3	-0.2	0.3	0.3
Latency to leave start box in cocaine runway, M	1.5	1.4	2.6	1.5	1.6	-1.3	-0.7	-0.2
Std. dev. time between licks in bursts	0.3	0.3	0.6	-0.8	-0.7	0.7	0.3	0.1
Total sessions with >9 infusions	1.1	1.2	2.5	0.1	-0.0	-1.5	1.2	1.6
Short access day 1 total inactive lever presses	1.7	1.9	4.2	1.9	1.3	-2.0	-0.6	0.2
Short access day 10 total inactive lever presses	0.3	0.3	0.7	0.8	0.5	-0.4	-0.6	-0.4
Short access day 1 total infusions	1.9	2.0	5.6	1.3	1.2	-2.4	0.3	1.1
Short access day 10 total infusions	1.0	1.1	2.9	0.8	0.0	-1.7	0.7	1.3
Short access total infusions	1.2	1.3	3.3	0.6	0.4	-1.8	0.9	1.4
Short access day 1 locomotion	0.7	0.8	1.5	-0.2	-1.0	-0.5	1.0	1.2
Short access day 10 total locomotion	0.7	0.8	1.5	-1.2	-0.9	1.2	0.2	-0.2
Short access total locomotion	0.3	0.4	0.8	0.2	-0.4	-0.7	0.6	0.9
One hour access (0.3 mA shock)	0.3	0.4	1.2	0.4	0.3	-1.1	0.4	0.7
Compulsive drug intake	0.1	0.1	0.2	0.3	-0.0	-0.5	0.1	0.2
One hour access (shock baseline)	0.5	0.6	1.4	0.6	0.1	-1.2	0.5	0.9
Social response proportion	1.8	1.9	4.2	-1.7	-2.0	1.5	0.5	-0.0
Social responses	0.3	0.4	0.9	1.0	0.5	-0.6	-0.6	-0.3
Social time	0.1	0.1	0.2	-0.1	-0.3	-0.2	0.3	0.4
Soleus weight	1.1	3.1	6.8	0.5	-0.7	-2.0	2.0	2.6
Bone: stiffness	2.9	4.5	6.8	2.6	2.6	-1.6	-2.2	-1.4
Tibialis anterior weight	5.1	17.5	31.8	5.6	5.0	-4.6	-2.9	-1.0
Time to tail flick, vehicle, before self-admin	1.3	1.4	2.3	-1.4	-1.5	1.2	0.9	0.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.2	0.1	-0.2	0.1	0.2
Time to tail flick, test, before self-admin	0.4	0.4	0.9	0.3	0.9	0.0	-0.7	-0.7
Time to tail flick, test, after self-admin	0.5	0.5	1.2	0.4	0.4	0.4	-1.1	-1.0
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	0.6	0.8	-0.6	-0.5	-0.2
Delta time to tail flick, test, before/after SA	0.2	0.1	0.5	-0.2	-0.7	0.4	0.1	0.0
Tibia length	0.4	1.2	2.4	0.5	-0.1	-1.5	1.1	1.5
Ambulatory time before self-admin	3.2	3.3	6.7	2.5	1.7	-2.6	-0.5	0.4
Ambulatory time after self-admin	0.4	0.5	1.3	0.6	1.1	-0.7	-0.4	-0.2
Bone: tissue strength	0.2	0.2	0.3	0.3	0.4	-0.1	-0.5	-0.4
Total heroin consumption	0.6	0.7	1.6	-0.2	-0.5	-0.5	1.2	1.3
Bone: trabecular number	0.9	1.5	2.6	1.2	1.3	-0.3	-1.6	-1.3
Bone: trabecular spacing	0.2	0.2	0.6	-0.0	0.2	0.5	-0.6	-0.7
Bone: trabecular thickness	0.1	0.1	0.3	-0.5	0.2	0.5	0.1	-0.1
Bone: trabecular tissue density	2.1	3.0	5.1	2.2	2.2	-1.4	-1.5	-0.9
Water consumed over 24 hours	0.7	0.9	1.6	1.0	1.3	-0.7	-0.9	-0.6
Number of responses in last shaping day	2.2	2.3	4.7	1.0	-0.4	-2.2	1.3	2.0