Hub : Genes

LOC102547621

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	XR_010066508.1	0.05	0.03	2.5e-06	0.04	0.05	0.05	0.04	1.6e-05	2.8e-06	5.4e-06	9.0e-06
2	Adipose	alternative TSS	XR_010066509.1	0.02	0.02	7.9e-03	0.02	0.01	0.02	0.02	1.2e-03	2.1e-02	2.6e-03	2.7e-03
3	Liver	gene expression	LOC102547621	0.44	0.1	0.0e+00	0.58	0.56	0.57	0.58	4.5e-79	2.5e-74	1.0e-77	3.8e-78
4	Liver	isoform ratio	XR_010066506.1	0.18	0.08	0.0e+00	0.27	0.25	0.26	0.26	1.3e-29	2.0e-27	1.4e-28	5.7e-29

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.5	2.6	2.9	-1.4	1.7	-1.7	-1.7
Area under the delay curve	1.0	1.2	1.5	0.9	-1.1	1.1	1.2
BMI with tail	1.7	5.8	6.6	-2.3	2.6	-2.6	-2.2
BMI without tail	2.4	7.3	8.4	-2.6	2.9	-2.9	-2.3
Body weight	2.8	12.0	14.9	-3.9	3.5	-3.5	-3.0
Weight adjusted by age	0.0	0.1	0.1	-0.3	0.1	-0.1	0.3
Bone surface	0.8	1.4	1.4	-1.2	1.2	-1.2	-1.1
Bone volume	0.7	1.3	1.5	-1.0	1.2	-1.2	-1.1
Breakpoint value in progressive ratio session	2.4	2.9	4.8	0.8	-1.8	1.8	2.2
Number of licking bursts	4.6	7.6	7.7	-2.8	2.7	-2.7	-2.8
Context. condit. distance diff. score	0.1	0.1	0.1	0.4	-0.3	0.3	0.1
Locomotion velocity, session 1	0.2	0.2	0.4	-0.6	-0.5	0.5	0.4
Locomotion distance, session 1	0.1	0.1	0.3	-0.6	0.0	-0.0	0.1
Locomotion velocity, session 2	2.5	3.0	3.4	-1.6	1.8	-1.8	-1.6
Locomotion distance, session 2	1.6	2.2	3.4	-1.9	1.4	-1.4	-1.3
Locomotion velocity, session 3	0.1	0.1	0.1	-0.3	-0.3	0.3	0.1
Locomotion distance, session 3	1.5	1.7	2.5	-1.6	1.2	-1.2	-1.0
Stereotopy head waving bouts, day 3	0.4	0.4	0.7	0.0	-0.8	0.8	0.6
Stereotopy head waving duration, day 3	0.4	0.5	0.8	0.3	-0.9	0.9	0.5
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	-0.3	0.3	0.3
Locomotion distance, session 7	0.1	0.1	0.3	-0.6	0.3	-0.3	-0.2
Stereotopy head waving bouts, day 7	1.0	1.1	1.7	-1.3	0.9	-0.9	-1.1
Stereotopy head waving duration, day 7	0.6	0.7	1.0	-1.0	0.6	-0.6	-0.9
Locomotion velocity, session 8	0.0	0.1	0.1	-0.1	-0.3	0.3	0.1
Locomotion distance, session 8	0.1	0.1	0.3	-0.5	0.1	-0.1	-0.2
Degree of sensitization distance	0.9	1.0	1.0	1.0	-1.0	1.0	0.9
Degree of sensitization stereotypy	1.4	1.5	1.8	-1.3	1.2	-1.2	-1.3
Conditioned locomotion	0.1	0.1	0.2	-0.0	-0.4	0.4	0.4
Cocaine response after cond. corrected	2.5	3.0	3.6	1.2	-1.9	1.9	1.8
Cocaine response after cond. not corrected	2.2	2.5	3.1	1.0	-1.8	1.8	1.7
Cocaine response before conditioning	1.0	1.1	1.2	-1.0	1.1	-1.1	-1.1
Saline control response	0.6	0.8	1.8	-1.4	0.6	-0.6	-0.8
Bone: connectivity density	0.7	1.2	1.4	-0.8	1.2	-1.2	-1.1
Bone: cortical apparent density	0.2	0.3	0.4	0.0	0.5	-0.5	-0.6
Bone: cortical area	3.5	5.4	6.2	-2.1	2.5	-2.5	-2.2
Bone: cortical porosity	0.2	0.2	0.3	0.5	-0.5	0.5	0.4
Bone: cortical porosity	0.0	0.0	0.0	-0.0	-0.2	0.2	0.0
Bone: cortical thickness	1.5	2.6	3.2	-1.2	1.8	-1.8	-1.6
Bone: cortical thickness	0.0	0.0	0.2	0.4	0.0	-0.0	0.2
Bone: cortical tissue density	0.1	0.2	0.3	0.1	0.4	-0.4	-0.5
Condit. Reinf. active minus inactive responses	0.7	0.8	0.9	-0.8	0.9	-0.9	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	0.9	-0.7	0.7	0.6
Condit. Reinf. active responses	3.4	4.2	4.7	-1.9	2.2	-2.2	-1.9
Condit. Reinf. inactive responses	4.0	4.9	5.6	-2.1	2.4	-2.4	-2.0
Incentive salience index mean	4.6	5.6	6.0	-2.5	2.4	-2.4	-2.2
Condit. Reinf. lever presses	9.6	13.4	16.2	-4.0	3.6	-3.6	-3.5
Condit. Reinf. active minus inactive responses	0.8	1.0	1.1	-0.9	1.0	-1.0	-1.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.3
Condit. Reinf. active responses	2.5	3.5	3.6	-1.8	1.9	-1.9	-1.8
Condit. Reinf. inactive responses	3.8	5.0	5.3	-2.1	2.3	-2.3	-2.3
Condit. Reinf. lever presses	3.7	5.2	5.6	-2.0	2.4	-2.4	-2.3
Condit. Reinf. lever reinforcers received	2.9	4.0	4.1	-2.0	2.0	-2.0	-2.0
Conditioned reinforcement - actives	0.1	0.2	0.4	-0.4	-0.6	0.6	-0.4
Conditioned reinforcement - inactives	0.4	0.5	1.0	0.1	-1.0	1.0	-0.2
Conditioned locomotion	0.1	0.2	0.2	-0.3	-0.5	0.5	0.3
Patch foraging indifference point 0 sec	0.1	0.3	0.3	-0.5	-0.5	0.5	0.5
Patch foraging indifference point AUC	6.1	8.8	10.2	-3.2	3.0	-3.0	-2.7
Delay disc. indifference point, 0s delay	1.5	1.6	1.9	1.0	-1.4	1.4	1.3
Delay disc. indifference point, 16s delay	1.8	2.0	2.5	1.0	-1.6	1.6	1.5
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.3	0.3	-0.3	-0.5
Delay disc. indifference point, 24s delay	0.1	0.2	0.2	0.5	-0.3	0.3	0.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.4	-0.4	0.4	0.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.0	0.0	-0.0	0.2
Indifference point function ln k	1.9	3.3	3.6	1.9	-1.8	1.8	1.7
Indifference point function log k	1.9	3.3	3.6	1.9	-1.8	1.8	1.7
Patch foraging total patch changes 0 sec	0.1	0.2	0.8	-0.9	-0.1	0.1	0.1
Patch foraging total patch changes 12 sec	1.6	2.1	2.4	-1.5	1.4	-1.4	-1.4
Patch foraging total patch changes 18 sec	0.3	0.5	0.7	-0.9	0.7	-0.7	-0.5
Patch foraging total patch changes 24 sec	1.1	1.8	2.7	-1.7	1.2	-1.2	-1.2
Patch foraging total patch changes 6 sec	1.2	1.8	3.6	-1.9	1.1	-1.1	-1.1
Patch foraging time to switch 0 sec	1.3	2.6	3.8	1.9	-1.5	1.5	1.4
Patch foraging water rate 0 sec	0.6	1.4	2.4	-1.5	1.1	-1.1	-0.9
Patch foraging water rate 12 sec	0.0	0.0	0.0	-0.2	-0.2	0.2	0.1
Patch foraging water rate 18 sec	0.5	0.8	1.5	-0.7	0.8	-0.8	-1.2
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.2	0.2	-0.2	-0.4
Patch foraging water rate 6 sec	1.0	1.5	2.0	-1.3	1.0	-1.0	-1.4
Seeking ratio, delayed vs. immediate footshock	3.8	4.6	5.0	-2.1	2.2	-2.2	-2.0
Distance traveled before self-admin	3.7	4.8	7.4	-2.7	2.0	-2.0	-2.0
Distance traveled after self-admin	3.1	3.8	4.9	-1.9	1.8	-1.8	-2.2
Extensor digitorum longus weight	5.0	19.5	22.7	-4.8	4.3	-4.3	-4.2
Bone: elastic displacement	5.3	6.2	8.5	2.9	-2.2	2.2	2.5
Bone: elastic work	1.0	1.4	3.3	1.8	-0.8	0.8	1.0
Bone: endosteal estimation	0.9	1.9	2.9	-1.7	1.3	-1.3	-1.1
Bone: endosteal perimeter	0.8	1.7	2.9	-1.7	1.2	-1.2	-0.9
Epididymis fat weight	0.4	1.3	1.8	-1.0	1.3	-1.3	-0.8
Delta time in closed arm before/after self-admin	1.0	0.9	1.3	-0.5	1.2	-1.2	-0.9
Delta time in open arm before/after self-admin	0.6	0.6	1.0	0.4	-1.0	1.0	0.6
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.2	0.1	-0.1	0.1
Delay discount exponential model param	0.9	1.0	1.4	-0.8	1.0	-1.0	-1.2
Extinction: sum of active levers before priming	3.4	3.8	4.6	1.8	-2.1	2.1	1.7
Active lever presses in extinction session 6	0.5	0.5	0.8	0.7	-0.6	0.6	0.9
Bone: final force	2.2	3.5	3.6	-1.9	1.9	-1.9	-1.8
Bone: final moment	1.9	3.0	3.2	-1.7	1.8	-1.8	-1.7
Food consumed during 24 hour testing period	0.8	1.1	1.4	-1.2	1.0	-1.0	-1.0
Glucose	2.2	3.4	3.7	-1.9	1.9	-1.9	-1.6
Heart weight	0.5	0.8	1.1	-0.9	1.0	-1.0	-0.5
Delay discount hyperbolic model param	0.6	0.7	1.0	-0.6	0.8	-0.8	-1.0
Intermittent access intake day 1-15 change	0.8	1.7	1.9	-1.1	1.4	-1.4	-1.2
Intermittent access intake escalation	0.8	1.6	1.9	-1.1	1.4	-1.4	-1.2
Intermittent access intake escalation 2	2.7	3.1	4.3	-1.4	1.8	-1.8	-2.1
Intermitt. access day 1 inactive lever presses	0.4	1.6	2.0	-1.2	1.4	-1.4	-0.8
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	-0.6	0.5	-0.5	-0.3
Intermitt. access escalation Index	0.4	0.5	0.7	-0.8	0.8	-0.8	-0.4
Intermittent access day 1 total infusions	2.5	4.1	5.6	1.5	-2.4	2.4	1.7
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.2
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	-0.7	-0.1	0.1	-0.8
Intermittent access total infusions	0.2	0.2	0.3	-0.3	-0.6	0.6	-0.2
Intermittent access day 1 locomotion	2.8	3.6	4.4	1.5	-2.1	2.1	1.8
Intermittent access day 15 total locomotion	1.4	2.5	3.0	1.3	-1.7	1.7	1.5
Intermittent access total locomotion	1.8	2.1	2.8	1.3	-1.7	1.7	1.1
Intermittent access standard deviation	0.2	0.4	0.6	-0.8	0.6	-0.6	-0.7
Left kidney weight	0.3	1.5	2.5	-1.6	1.1	-1.1	-0.9
Right kidney weight	0.3	1.2	1.5	-1.2	1.2	-1.2	-0.7
Cocaine induced anxiety	0.1	0.1	0.3	-0.1	-0.3	0.3	-0.6
Post-drug Anxiety	0.7	0.7	1.4	-1.0	0.4	-0.4	-1.2
Baseline Anxiety	0.7	0.8	1.0	-0.8	1.0	-1.0	-0.7
Tail length	1.9	7.2	8.0	-2.8	2.7	-2.7	-2.5
Length with tail	1.0	4.2	6.8	-2.6	1.9	-1.9	-1.7
Length without tail	0.1	0.2	0.2	-0.4	-0.5	0.5	0.3
Times rat made contact with spout	0.7	0.8	1.0	-0.7	0.9	-0.9	-1.0
Lifetime Intake	0.3	0.4	0.8	-0.4	-0.9	0.9	-0.1
Liver weight, left	0.1	0.1	0.2	0.1	-0.3	0.3	0.5
Liver weight, right	0.5	0.8	1.1	1.0	-1.1	1.1	0.4
Locomotor activity	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Locomotor testing distance	0.2	0.3	0.4	0.2	-0.6	0.6	0.5
Locomotor testing rearing	0.6	1.3	1.8	-1.3	0.9	-0.9	-1.3
Locomotion in novel chamber	0.1	0.2	0.4	0.7	-0.3	0.3	0.1
Locomotion in novel chamber post-restriction	1.7	2.8	3.3	-1.2	1.8	-1.8	-1.7
Fecal boli incidents, locomotor time 1	0.8	1.2	1.8	1.3	-0.8	0.8	1.3
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	-0.8	0.5	-0.5	-0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.2	-0.3	0.3	0.6
Bouts of movement, locomotor time 1	1.3	1.4	1.8	1.3	-1.2	1.2	1.0
Total resting periods, locomotor time 1	1.6	1.7	2.6	1.6	-1.3	1.3	1.1
Rest time, locomotor task time 1	0.3	0.4	1.6	1.3	-0.1	0.1	0.2
Distance moved, locomotor task time 1	0.7	1.0	2.7	-1.6	0.6	-0.6	-0.7
Vertical activity count, locomotor time 1	0.2	0.4	1.5	-1.2	0.0	-0.0	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.2	0.2	-0.2	0.1
Bouts of movement, locomotor time 2	0.4	0.6	0.8	-0.9	0.7	-0.7	-0.8
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.5	0.3	-0.3	-0.5
Rest time, locomotor task time 2	0.5	0.7	0.9	1.0	-0.8	0.8	0.7
Distance moved, locomotor task time 2	1.0	1.1	1.4	-0.8	1.2	-1.2	-1.1
Vertical activity count, locomotor time 2	0.4	0.5	0.8	-0.9	0.8	-0.8	-0.5
Light reinforcement 1	0.3	0.7	2.5	-1.6	0.4	-0.4	-0.4
Light reinforcement 2	0.3	0.4	0.5	-0.7	-0.7	0.7	0.4
Bone: marrow area	1.0	2.2	3.1	-1.8	1.5	-1.5	-1.3
Bone: maximum diameter	2.9	5.4	5.9	-2.3	2.4	-2.4	-2.1
Bone: maximum force	4.1	7.2	7.5	-2.7	2.7	-2.7	-2.6
Bone: maximum moment	3.4	6.0	6.4	-2.4	2.5	-2.5	-2.4
Mean time between licks in bursts	0.2	0.5	0.5	0.7	-0.6	0.6	0.7
Mean num. licks in bursts	2.1	3.3	3.8	1.9	-1.8	1.8	1.7
Cd content in liver	1.0	1.1	1.5	-1.2	0.9	-0.9	-1.0
Co content in liver	0.6	0.7	0.9	0.6	-1.0	1.0	0.8
Cu content in liver	1.4	1.6	2.0	1.4	-1.2	1.2	1.2
Fe content in liver	1.0	1.3	1.7	0.8	-1.3	1.3	0.9
K content in liver	0.5	0.5	0.6	0.4	-0.8	0.8	0.8
Mg content in liver	1.4	1.4	1.6	1.1	-1.2	1.2	1.3
Mn content in liver	1.6	1.8	2.0	-1.3	1.4	-1.4	-1.2
Na content in liver	1.0	1.1	1.3	1.1	-1.1	1.1	0.8
Rb content in liver	5.2	6.0	6.5	2.5	-2.6	2.6	2.2
Se content in liver	3.1	3.6	4.0	-1.8	1.9	-1.9	-2.0
Sr content in liver	0.2	0.1	0.3	-0.5	0.4	-0.4	0.0
Zn content in liver	0.1	0.1	0.1	-0.1	0.4	-0.4	-0.1
Bone: minimum diameter	0.0	0.0	0.0	0.2	0.0	-0.0	0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.4	0.6	0.2	-0.2	-0.2
Time in novel zone, hab. session 1	2.9	2.9	3.7	1.1	-1.8	1.8	1.9
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.0	0.1	-0.1	0.1
Total locomotion distance, hab. session 1	0.6	0.8	1.2	-0.5	1.1	-1.1	-0.9
Locomotion velocity, hab. session 1	2.0	2.8	3.3	-1.4	1.8	-1.8	-1.6
Time in familiar zone, hab. session 2	0.3	0.3	0.8	0.9	-0.3	0.3	0.4
Time in novel zone, hab. session 2	2.0	2.0	2.6	0.9	-1.6	1.6	1.4
Total zone transitions, hab. session 2	0.3	0.4	0.7	-0.8	0.6	-0.6	-0.4
Total locomotion distance, hab. session 2	0.8	1.0	1.1	-1.0	1.1	-1.1	-0.9
Locomotion velocity, hab. session 2	1.1	1.4	1.5	-1.2	1.2	-1.2	-1.1
Novel to familiar place preference ratio	4.5	4.9	5.7	1.9	-2.3	2.3	2.4
Novelty place preference	5.8	6.2	6.8	2.2	-2.6	2.6	2.6
Time in novel zone, NPP test	7.0	7.5	8.0	2.4	-2.8	2.8	2.8
Total zone transitions, NPP test	0.3	0.5	1.0	-1.0	0.6	-0.6	-0.5
Total locomotion distance, NPP test	1.3	1.8	2.6	-1.6	1.3	-1.3	-1.0
Locomotion velocity, NPP test	1.9	2.6	3.4	-1.8	1.6	-1.6	-1.4
Intraocular pressure	1.7	2.5	3.8	-2.0	1.4	-1.4	-1.4
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.1	0.1	-0.1	-0.5
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	0.6	-0.5	0.5	-0.1
Parametrial fat weight	0.2	0.4	0.8	0.3	-0.5	0.5	0.9
Pavlov. Cond. lever latency	6.9	8.7	10.2	3.2	-2.9	2.9	2.8
Pavlov. Cond. magazine entry latency	0.6	0.8	1.0	-0.8	1.0	-1.0	-0.7
Pavlov. Cond. change in total contacts	2.8	3.0	3.5	-1.9	1.7	-1.7	-1.6
Pavlov. Cond. index score	3.6	4.6	4.7	-2.2	2.2	-2.2	-2.0
Pavlov. Cond. latency score	3.2	4.1	4.4	-2.1	2.0	-2.0	-1.9
Pavlov. Cond. lever contacts	6.6	7.9	8.9	-3.0	2.8	-2.8	-2.7
Pavlov. Cond. magazine entry number	1.0	1.2	1.5	0.9	-1.2	1.2	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.3	-0.5	0.6	-0.6	-0.5
Pavlov. Cond. lever-magazine prob. diff.	3.8	4.7	5.0	-2.1	2.2	-2.2	-2.1
Pavlov. Cond. response bias	4.4	5.4	5.7	-2.4	2.4	-2.4	-2.1
Pavlov. Cond. lever latency	3.5	4.7	5.2	1.9	-2.3	2.3	2.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	-0.3	0.3	0.1
Pavlov. Cond. change in total contacts	1.4	2.2	2.9	-0.9	1.7	-1.7	-1.5
Pavlov. Cond. index score	0.6	0.8	1.0	-0.5	1.0	-1.0	-1.0
Pavlov. Cond. latency score	0.8	1.1	1.3	-0.6	1.1	-1.1	-1.1
Pavlov. Cond. lever contacts	2.6	3.6	4.0	-1.6	2.0	-2.0	-2.0
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	0.3	-0.8	0.8	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.6	0.5	-0.5	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.1	-0.5	1.0	-1.0	-1.0
Pavlov. Cond. response bias	1.5	2.1	2.4	-1.1	1.5	-1.5	-1.5
Time in closed arm before self-admin	0.4	0.5	0.7	0.9	-0.6	0.6	0.7
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	0.3	-0.3	-0.1
Time in open arm before self-admin	0.5	0.6	1.3	-1.1	0.6	-0.6	-0.3
Time in open arm after self-admin	0.3	0.3	0.9	-1.0	0.2	-0.2	-0.4
Bone: periosteal estimation	2.0	4.3	4.6	-2.1	2.1	-2.1	-1.9
Bone: periosteal perimeter	0.5	0.9	1.3	-1.1	0.9	-0.9	-0.7
Bone: post-yield work	1.8	2.7	4.1	-2.0	1.5	-1.5	-1.4
Progressive ratio test 1 active lever presses	1.1	1.3	2.5	0.3	-1.6	1.6	0.4
Progressive ratio test 1 breakpoint	0.9	1.1	2.1	0.2	-1.4	1.4	0.3
Progressive ratio test 1 inactive lever presses	0.3	0.4	1.2	-1.1	0.1	-0.1	-0.5
Progressive ratio test 2 active lever presses	1.8	2.1	3.8	0.5	-1.9	1.9	0.7
Progressive ratio test 2 breakpoint	1.9	2.2	3.9	0.5	-2.0	2.0	0.8
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.4
Incentive Sensitization - Responses	0.4	0.6	1.2	-0.0	-1.1	1.1	-0.1
Incentive Sensitization - Breakpoint	0.5	0.6	1.3	0.1	-1.1	1.1	-0.0
Sum of active levers in priming session hrs 5-6	5.0	4.6	5.5	1.8	-2.2	2.2	2.4
Progressive ratio	0.0	0.0	0.0	0.2	-0.1	0.1	0.2
Food seeking constrained by brief footshock	5.3	6.6	10.2	-3.2	2.1	-2.1	-2.7
Seeking ratio, punishment vs. effort	1.8	2.6	3.8	-2.0	1.3	-1.3	-1.8
Retroperitoneal fat weight	0.3	1.1	1.9	1.4	-0.8	0.8	1.1
Reaction time number correct	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1
Reaction time mean minus median	0.6	1.4	2.1	-0.4	1.5	-1.5	-1.1
Reaction time mean minus median AUC	0.8	2.0	2.5	-0.9	1.6	-1.6	-1.5
Reaction time num false alarms	0.1	0.2	0.3	-0.2	0.4	-0.4	-0.5
Reaction time num false alarms AUC	0.4	0.7	0.8	-0.8	0.8	-0.8	-0.9
Reaction time trials correct on left	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1
Reaction time trials on left	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2
Reaction time mean	0.4	0.6	1.9	1.4	-0.3	0.3	0.6
Reaction time mean AUC	0.4	0.7	2.2	1.5	-0.4	0.4	0.6
Median of all reaction times	1.5	2.1	3.9	2.0	-1.1	1.1	1.4
Reaction time omissions	1.7	2.5	3.6	1.7	-1.3	1.3	1.9
Reaction time false alarm rate	0.1	0.1	0.2	-0.1	0.3	-0.3	-0.4
Reaction time premature initiation rate	1.4	2.0	3.2	1.8	-1.1	1.1	1.5
Reaction time premature initiations	0.9	1.6	2.4	1.5	-1.0	1.0	1.4
Std. dev. reaction times	0.2	0.3	0.6	0.4	0.7	-0.7	-0.3
Reaction time trials completed	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2
Reaction time trials AUC	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.3	0.3	-0.3	-0.0
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.3	-0.3	0.3	0.2
Latency to leave start box in cocaine runway	0.9	1.1	1.3	-1.0	1.1	-1.1	-0.8
Latency to leave start box in cocaine runway, F	0.2	0.2	0.6	0.2	-0.3	0.3	0.8
Latency to leave start box in cocaine runway, M	3.2	3.0	3.4	-1.9	1.7	-1.7	-1.7
Std. dev. time between licks in bursts	0.3	0.4	0.5	0.7	-0.7	0.7	0.5
Total sessions with >9 infusions	0.4	0.4	0.7	-0.5	-0.9	0.9	-0.2
Short access day 1 total inactive lever presses	0.4	0.5	1.4	-1.2	0.3	-0.3	-0.6
Short access day 10 total inactive lever presses	0.7	1.7	1.8	-1.2	1.4	-1.4	-1.3
Short access day 1 total infusions	0.3	0.4	0.6	-0.7	-0.8	0.8	-0.2
Short access day 10 total infusions	0.6	0.7	1.3	0.1	-1.1	1.1	0.6
Short access total infusions	0.9	1.1	2.1	-0.1	-1.5	1.5	0.4
Short access day 1 locomotion	2.0	2.5	3.0	1.1	-1.7	1.7	1.6
Short access day 10 total locomotion	0.5	1.0	1.4	1.2	-1.0	1.0	0.7
Short access total locomotion	0.9	1.1	1.4	0.7	-1.2	1.2	1.0
One hour access (0.3 mA shock)	0.2	0.3	0.5	-0.3	-0.7	0.7	0.1
Compulsive drug intake	0.2	0.2	0.5	-0.1	0.7	-0.7	-0.2
One hour access (shock baseline)	0.4	0.6	1.1	-0.2	-1.1	1.1	0.4
Social response proportion	1.8	2.1	3.0	1.7	-1.1	1.1	1.7
Social responses	0.6	0.8	0.9	-1.0	1.0	-1.0	-0.7
Social time	0.0	0.0	0.1	0.1	-0.1	0.1	0.3
Soleus weight	0.2	0.5	0.9	-0.1	-0.7	0.7	0.9
Bone: stiffness	5.4	8.8	9.0	-3.0	3.0	-3.0	-2.9
Tibialis anterior weight	7.5	25.6	31.6	-5.6	4.9	-4.9	-4.7
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.3	1.2	-0.7	0.7	0.8
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.1	-0.1	0.3	-0.3	-0.3
Time to tail flick, test, before self-admin	0.3	0.4	0.7	-0.7	0.4	-0.4	-0.9
Time to tail flick, test, after self-admin	2.3	2.4	3.3	-1.0	1.8	-1.8	-1.3
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.5	-0.7	0.5	-0.5	-0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.3	0.5	-0.5	0.1
Tibia length	0.0	0.1	0.2	-0.4	-0.3	0.3	0.4
Ambulatory time before self-admin	2.2	3.2	5.5	-2.4	1.6	-1.6	-1.6
Ambulatory time after self-admin	0.9	1.1	1.6	-1.3	0.8	-0.8	-1.1
Bone: tissue strength	0.2	0.2	0.3	-0.4	0.6	-0.6	-0.4
Total heroin consumption	1.8	2.1	2.7	0.9	-1.6	1.6	1.5
Bone: trabecular number	1.2	2.0	2.3	-1.2	1.5	-1.5	-1.5
Bone: trabecular spacing	0.0	0.0	0.1	-0.1	0.3	-0.3	-0.2
Bone: trabecular thickness	0.1	0.2	0.3	0.5	-0.3	0.3	0.4
Bone: trabecular tissue density	3.5	5.2	6.3	-2.5	2.2	-2.2	-2.2
Water consumed over 24 hours	1.1	1.4	1.7	-1.2	1.1	-1.1	-1.3
Number of responses in last shaping day	1.0	1.1	2.0	-0.0	-1.1	1.1	1.4