Hub : Genes

Sart1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Sart1 0.05 0.04 4.4e-04 0.01 0.03 0.02 0.02 3.3e-02 1.9e-03 6.9e-03 7.0e-03
2 Liver gene expression Sart1 0.06 0.04 5.8e-05 0.04 0.03 0.02 0.03 3.5e-05 7.6e-04 1.7e-03 6.0e-04
3 PL gene expression Sart1 0.05 0.04 5.6e-05 0.05 0.03 0.03 0.03 8.3e-06 4.3e-04 9.2e-04 4.7e-04
4 BLA gene expression Sart1 0.06 0.05 5.0e-03 0.03 0.02 0 0.02 1.0e-02 2.6e-02 1.6e-01 4.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.61.12.31.5-0.8-0.9-0.7
Area under the delay curve0.00.10.20.10.30.4-0.1
BMI with tail2.17.213.03.6-2.4-2.3-2.1
BMI without tail0.63.45.62.4-1.5-1.7-1.6
Body weight3.214.016.94.1-3.8-3.5-3.5
Weight adjusted by age0.72.02.91.3-1.4-1.7-1.0
Bone surface4.58.912.03.5-3.1-3.0-2.3
Bone volume1.53.05.02.2-1.7-1.7-1.0
Breakpoint value in progressive ratio session2.34.24.92.2-2.1-2.2-1.6
Number of licking bursts0.10.40.50.7-0.7-0.7-0.4
Context. condit. distance diff. score1.92.32.7-1.61.71.61.3
Locomotion velocity, session 10.10.10.3-0.20.10.2-0.5
Locomotion distance, session 10.60.81.41.2-0.7-0.6-1.0
Locomotion velocity, session 23.13.74.32.1-1.8-1.7-2.0
Locomotion distance, session 21.01.31.91.4-0.9-0.9-1.3
Locomotion velocity, session 30.10.10.2-0.00.50.30.2
Locomotion distance, session 30.00.00.0-0.10.20.10.1
Stereotopy head waving bouts, day 30.60.71.4-0.60.81.20.6
Stereotopy head waving duration, day 30.81.01.5-0.81.01.20.9
Locomotion velocity, session 70.20.20.40.00.60.30.5
Locomotion distance, session 70.10.10.20.3-0.0-0.0-0.4
Stereotopy head waving bouts, day 70.10.20.60.10.2-0.00.8
Stereotopy head waving duration, day 70.60.81.31.1-0.8-1.1-0.2
Locomotion velocity, session 81.21.42.21.0-1.2-1.1-1.5
Locomotion distance, session 80.20.20.4-0.30.60.60.4
Degree of sensitization distance0.10.10.10.4-0.2-0.1-0.4
Degree of sensitization stereotypy0.40.50.90.8-0.6-0.90.1
Conditioned locomotion1.72.02.21.3-1.4-1.5-1.4
Cocaine response after cond. corrected1.01.42.1-1.31.51.10.8
Cocaine response after cond. not corrected0.71.01.5-1.11.20.90.8
Cocaine response before conditioning0.70.81.21.0-1.1-0.9-0.4
Saline control response4.36.06.42.5-2.5-2.3-2.5
Bone: connectivity density2.94.66.82.6-2.0-2.1-1.8
Bone: cortical apparent density0.10.10.20.1-0.4-0.4-0.3
Bone: cortical area0.71.11.61.0-1.1-1.3-0.9
Bone: cortical porosity0.20.20.40.6-0.4-0.2-0.5
Bone: cortical porosity0.60.70.90.9-0.8-0.4-0.9
Bone: cortical thickness3.35.47.11.9-2.3-2.7-2.4
Bone: cortical thickness0.70.91.50.6-0.8-1.0-1.2
Bone: cortical tissue density0.20.20.30.3-0.6-0.6-0.5
Condit. Reinf. active minus inactive responses0.20.30.50.7-0.4-0.5-0.3
Condit. Reinf. active-inactive response ratio0.00.00.10.3-0.1-0.2-0.1
Condit. Reinf. active responses0.10.10.30.5-0.1-0.40.0
Condit. Reinf. inactive responses0.00.10.20.10.3-0.10.4
Incentive salience index mean0.40.50.91.0-0.6-0.7-0.5
Condit. Reinf. lever presses0.50.71.01.0-0.9-0.9-0.5
Condit. Reinf. active minus inactive responses0.10.20.4-0.00.20.40.6
Condit. Reinf. active-inactive response ratio0.71.12.1-0.70.81.11.4
Condit. Reinf. active responses0.10.20.50.7-0.4-0.2-0.1
Condit. Reinf. inactive responses0.71.11.41.2-0.9-0.9-1.1
Condit. Reinf. lever presses1.92.83.92.0-1.8-1.6-1.1
Condit. Reinf. lever reinforcers received0.30.51.01.0-0.8-0.5-0.4
Conditioned reinforcement - actives0.00.10.4-0.2-0.00.00.6
Conditioned reinforcement - inactives1.74.67.1-2.02.01.82.7
Conditioned locomotion8.011.812.8-3.53.33.33.6
Patch foraging indifference point 0 sec0.00.00.1-0.0-0.00.30.0
Patch foraging indifference point AUC1.33.14.11.7-2.0-1.8-1.4
Delay disc. indifference point, 0s delay0.50.51.1-0.40.91.00.2
Delay disc. indifference point, 16s delay0.50.81.1-0.60.81.01.0
Delay disc. indifference point, 2s delay0.20.20.4-0.20.40.60.4
Delay disc. indifference point, 24s delay0.00.10.1-0.30.30.2-0.2
Delay disc. indifference point, 4s delay0.10.10.2-0.10.40.5-0.2
Delay disc. indifference point, 8s delay0.00.10.10.00.30.4-0.3
Indifference point function ln k4.012.214.7-3.63.73.82.7
Indifference point function log k4.012.214.7-3.63.73.82.7
Patch foraging total patch changes 0 sec0.00.00.1-0.1-0.10.3-0.2
Patch foraging total patch changes 12 sec5.26.98.02.8-2.8-2.5-2.4
Patch foraging total patch changes 18 sec0.40.91.21.1-1.0-0.8-0.8
Patch foraging total patch changes 24 sec0.82.93.71.5-1.9-1.5-1.8
Patch foraging total patch changes 6 sec1.42.32.51.6-1.5-1.5-1.6
Patch foraging time to switch 0 sec0.93.35.42.3-1.6-2.1-1.0
Patch foraging water rate 0 sec2.07.510.8-3.32.52.82.2
Patch foraging water rate 12 sec3.815.219.8-4.44.04.02.9
Patch foraging water rate 18 sec2.14.65.7-2.42.32.31.5
Patch foraging water rate 24 sec5.07.19.9-3.22.72.72.0
Patch foraging water rate 6 sec4.76.99.4-3.12.72.91.6
Seeking ratio, delayed vs. immediate footshock0.00.10.20.10.20.10.4
Distance traveled before self-admin0.30.61.01.0-0.8-0.7-0.4
Distance traveled after self-admin0.10.30.40.5-0.6-0.5-0.3
Extensor digitorum longus weight8.333.235.75.8-5.8-6.0-5.5
Bone: elastic displacement0.70.91.8-1.41.00.70.3
Bone: elastic work1.11.42.70.8-1.1-1.1-1.7
Bone: endosteal estimation0.61.62.6-0.71.21.61.3
Bone: endosteal perimeter0.92.33.2-0.91.41.71.8
Epididymis fat weight2.713.414.8-3.63.53.83.6
Delta time in closed arm before/after self-admin0.50.51.20.4-0.4-0.6-1.1
Delta time in open arm before/after self-admin0.10.20.30.3-0.4-0.50.3
Diff in mean of infusions in LGA sessions0.50.81.20.8-0.9-1.1-0.8
Delay discount exponential model param0.00.00.1-0.2-0.2-0.30.2
Extinction: sum of active levers before priming2.13.24.32.1-1.9-1.8-1.5
Active lever presses in extinction session 63.23.24.11.8-1.9-2.0-1.4
Bone: final force2.43.94.82.1-2.2-1.8-1.8
Bone: final moment2.23.64.42.0-2.1-1.7-1.7
Food consumed during 24 hour testing period0.00.00.0-0.2-0.1-0.10.1
Glucose2.23.54.4-1.42.12.01.9
Heart weight0.61.01.9-0.61.41.20.5
Delay discount hyperbolic model param0.00.10.1-0.1-0.2-0.40.1
Intermittent access intake day 1-15 change0.42.02.7-1.61.21.21.6
Intermittent access intake escalation0.31.62.4-1.41.01.01.6
Intermittent access intake escalation 21.01.62.1-1.41.01.11.5
Intermitt. access day 1 inactive lever presses0.00.20.3-0.40.40.20.6
Intermitt. access day 15 inactive lever presses0.52.64.7-1.31.61.12.2
Intermitt. access escalation Index1.44.25.8-1.92.12.41.7
Intermittent access day 1 total infusions1.03.04.6-1.22.01.52.1
Intermittent access day 15 total infusions3.07.411.0-2.52.72.33.3
Intermittent access terminal intake (last 3 days)3.45.99.5-2.12.51.93.1
Intermittent access total infusions3.54.16.7-1.52.21.62.6
Intermittent access day 1 locomotion1.22.23.3-1.11.71.21.8
Intermittent access day 15 total locomotion1.66.210.3-2.12.52.03.2
Intermittent access total locomotion7.18.513.4-2.43.02.53.7
Intermittent access standard deviation0.42.12.5-1.61.51.11.6
Left kidney weight0.53.74.5-1.81.92.11.9
Right kidney weight0.32.12.6-1.61.31.61.3
Cocaine induced anxiety0.00.00.10.2-0.2-0.30.1
Post-drug Anxiety0.70.81.00.9-1.0-0.9-0.7
Baseline Anxiety0.30.40.90.5-0.7-0.4-1.0
Tail length0.31.73.00.8-1.4-1.2-1.7
Length with tail1.98.610.82.5-3.1-2.8-3.3
Length without tail1.36.89.62.2-2.6-2.4-3.1
Times rat made contact with spout0.50.61.00.9-0.6-0.6-1.0
Lifetime Intake2.22.84.3-1.21.91.32.1
Liver weight, left0.81.42.1-1.41.31.20.8
Liver weight, right2.03.54.4-2.12.11.91.2
Locomotor activity2.03.24.2-2.11.91.91.0
Locomotor testing distance1.74.15.4-2.32.22.21.0
Locomotor testing rearing1.03.54.9-2.12.22.01.1
Locomotion in novel chamber5.77.78.7-2.72.73.02.7
Locomotion in novel chamber post-restriction1.64.75.2-2.12.22.22.3
Fecal boli incidents, locomotor time 10.00.10.4-0.10.1-0.20.6
Change in fecal boli incidents, locomotor task0.10.10.40.2-0.10.3-0.6
Time >=10cm from walls, locomotor time 10.60.81.9-0.40.70.71.4
Bouts of movement, locomotor time 11.31.72.01.2-1.4-1.4-1.0
Total resting periods, locomotor time 10.91.01.31.0-1.1-1.1-0.7
Rest time, locomotor task time 11.42.22.5-1.61.41.51.4
Distance moved, locomotor task time 10.10.30.60.8-0.3-0.5-0.4
Vertical activity count, locomotor time 10.10.91.2-0.91.10.81.0
Time >=10cm from walls, locomotor time 20.00.00.10.1-0.20.10.3
Bouts of movement, locomotor time 20.20.81.00.9-0.9-1.0-0.7
Total resting periods, locomotor time 20.10.40.50.7-0.7-0.7-0.4
Rest time, locomotor task time 21.83.03.5-1.81.91.71.6
Distance moved, locomotor task time 21.21.51.81.2-1.2-1.3-1.2
Vertical activity count, locomotor time 20.00.10.1-0.3-0.1-0.1-0.3
Light reinforcement 10.00.10.2-0.50.30.50.1
Light reinforcement 20.71.52.4-1.11.01.21.5
Bone: marrow area0.71.72.8-0.81.31.71.3
Bone: maximum diameter0.10.10.30.4-0.5-0.4-0.1
Bone: maximum force3.05.98.02.8-2.6-2.3-2.0
Bone: maximum moment2.95.47.32.7-2.4-2.2-1.9
Mean time between licks in bursts0.10.61.70.5-0.6-0.5-1.3
Mean num. licks in bursts0.10.20.4-0.40.70.60.1
Cd content in liver1.71.92.7-1.21.21.31.7
Co content in liver1.51.83.1-1.81.21.50.6
Cu content in liver0.00.00.10.20.10.10.2
Fe content in liver0.10.10.20.2-0.4-0.4-0.4
K content in liver0.70.60.90.9-0.7-0.7-0.9
Mg content in liver0.20.20.4-0.40.60.60.3
Mn content in liver3.84.25.82.1-2.1-2.4-1.5
Na content in liver0.20.30.50.3-0.7-0.3-0.6
Rb content in liver1.82.12.7-1.31.71.61.2
Se content in liver0.20.30.7-0.20.40.20.9
Sr content in liver2.82.42.91.2-1.7-1.7-1.6
Zn content in liver0.30.30.40.6-0.6-0.4-0.6
Bone: minimum diameter0.61.21.7-0.31.21.21.3
Time in familiar zone, hab. session 10.20.20.2-0.20.50.50.5
Time in novel zone, hab. session 10.20.20.5-0.70.40.4-0.1
Total zone transitions, hab. session 10.71.01.51.2-0.9-0.9-0.9
Total locomotion distance, hab. session 10.30.40.7-0.40.60.80.6
Locomotion velocity, hab. session 10.00.00.10.10.10.30.2
Time in familiar zone, hab. session 20.10.10.3-0.2-0.0-0.2-0.5
Time in novel zone, hab. session 20.10.10.20.4-0.20.00.1
Total zone transitions, hab. session 21.72.14.22.0-1.3-0.9-1.4
Total locomotion distance, hab. session 20.10.10.20.50.10.4-0.2
Locomotion velocity, hab. session 20.10.10.30.30.30.60.2
Novel to familiar place preference ratio0.91.21.81.2-1.2-1.4-0.3
Novelty place preference0.40.50.90.8-0.7-0.90.0
Time in novel zone, NPP test0.30.40.60.7-0.6-0.8-0.0
Total zone transitions, NPP test2.33.34.72.2-1.9-1.3-1.8
Total locomotion distance, NPP test0.10.10.30.5-0.30.2-0.4
Locomotion velocity, NPP test0.10.10.30.6-0.30.1-0.3
Intraocular pressure1.22.03.6-1.61.20.51.9
Delta distance traveled before/after self-admin0.10.10.2-0.50.20.2-0.1
Delta ambulatory time before/after self-admin0.00.10.1-0.3-0.10.0-0.4
Parametrial fat weight3.78.710.8-2.82.92.83.3
Pavlov. Cond. lever latency0.30.30.5-0.70.60.40.5
Pavlov. Cond. magazine entry latency0.20.30.70.8-0.6-0.1-0.1
Pavlov. Cond. change in total contacts0.10.10.20.5-0.3-0.10.4
Pavlov. Cond. index score0.10.20.40.5-0.6-0.2-0.1
Pavlov. Cond. latency score0.10.10.20.4-0.5-0.0-0.1
Pavlov. Cond. lever contacts0.10.10.20.5-0.3-0.1-0.3
Pavlov. Cond. magazine entry number0.20.20.5-0.50.70.30.1
Pavlov. Cond. intertrial magazine entries0.50.61.2-0.70.80.41.1
Pavlov. Cond. lever-magazine prob. diff.0.30.30.60.7-0.8-0.3-0.2
Pavlov. Cond. response bias0.10.20.30.5-0.6-0.3-0.0
Pavlov. Cond. lever latency0.40.60.9-0.81.00.90.3
Pavlov. Cond. magazine entry latency4.46.28.02.8-2.5-2.6-2.0
Pavlov. Cond. change in total contacts0.92.23.41.8-1.6-1.5-0.5
Pavlov. Cond. index score2.23.44.72.2-2.0-1.9-1.1
Pavlov. Cond. latency score1.82.84.02.0-1.8-1.8-1.0
Pavlov. Cond. lever contacts0.50.70.90.9-1.0-0.9-0.3
Pavlov. Cond. magazine entry number7.49.612.0-3.53.23.22.4
Pavlov. Cond. intertrial magazine entries0.81.82.2-1.41.21.51.3
Pavlov. Cond. lever-magazine prob. diff.2.74.25.62.4-2.2-2.1-1.3
Pavlov. Cond. response bias2.12.93.81.9-1.8-1.8-1.1
Time in closed arm before self-admin0.30.51.0-0.40.60.81.0
Time in closed arm after self-admin0.10.10.1-0.40.40.30.3
Time in open arm before self-admin0.20.30.5-0.50.50.3-0.7
Time in open arm after self-admin0.10.10.30.1-0.1-0.4-0.5
Bone: periosteal estimation0.00.00.10.20.00.10.3
Bone: periosteal perimeter0.10.20.40.6-0.4-0.3-0.1
Bone: post-yield work0.71.33.92.0-0.8-0.6-0.0
Progressive ratio test 1 active lever presses0.20.30.7-0.30.60.00.9
Progressive ratio test 1 breakpoint0.20.30.7-0.20.6-0.10.8
Progressive ratio test 1 inactive lever presses0.00.10.3-0.20.40.10.6
Progressive ratio test 2 active lever presses2.12.95.1-1.41.81.22.3
Progressive ratio test 2 breakpoint2.22.95.1-1.41.81.12.3
Progressive ratio test 2 inactive lever presses3.611.315.3-3.03.43.03.9
Incentive Sensitization - Responses0.00.10.20.30.0-0.20.4
Incentive Sensitization - Breakpoint0.00.10.40.00.20.00.6
Sum of active levers in priming session hrs 5-60.90.91.70.5-1.2-1.3-0.1
Progressive ratio0.51.43.01.7-1.0-1.0-0.7
Food seeking constrained by brief footshock0.10.10.20.4-0.4-0.4-0.4
Seeking ratio, punishment vs. effort0.71.73.0-1.71.31.30.6
Retroperitoneal fat weight10.044.648.1-6.66.86.96.3
Reaction time number correct0.10.20.40.2-0.6-0.4-0.6
Reaction time mean minus median0.74.86.22.3-2.2-2.5-1.7
Reaction time mean minus median AUC0.42.53.71.5-1.5-1.9-1.3
Reaction time num false alarms0.10.20.6-0.80.50.5-0.0
Reaction time num false alarms AUC0.10.10.4-0.0-0.1-0.3-0.6
Reaction time trials correct on left0.10.20.40.2-0.6-0.4-0.6
Reaction time trials on left0.10.30.50.3-0.7-0.5-0.7
Reaction time mean0.00.10.10.2-0.3-0.30.3
Reaction time mean AUC0.00.10.20.2-0.3-0.20.4
Median of all reaction times0.20.20.7-0.30.20.40.8
Reaction time omissions1.82.94.81.7-1.5-2.2-1.3
Reaction time false alarm rate0.10.10.2-0.50.40.10.0
Reaction time premature initiation rate2.84.47.51.8-1.9-1.8-2.7
Reaction time premature initiations2.06.29.92.1-2.4-2.2-3.1
Std. dev. reaction times0.41.42.11.2-1.2-1.4-0.7
Reaction time trials completed0.10.30.50.3-0.7-0.5-0.7
Reaction time trials AUC0.10.20.40.2-0.5-0.4-0.6
Run reversals in cocaine runway, females0.50.61.10.9-0.4-0.5-1.1
Run reversals in cocaine runway, males0.40.41.1-1.10.50.20.5
Latency to leave start box in cocaine runway0.10.10.10.20.40.10.4
Latency to leave start box in cocaine runway, F0.00.10.10.20.40.10.2
Latency to leave start box in cocaine runway, M0.10.10.10.3-0.2-0.40.0
Std. dev. time between licks in bursts0.10.10.4-0.40.10.1-0.6
Total sessions with >9 infusions0.10.10.20.50.0-0.20.1
Short access day 1 total inactive lever presses1.53.03.6-1.61.71.91.7
Short access day 10 total inactive lever presses0.10.50.7-0.70.80.50.6
Short access day 1 total infusions0.91.72.1-1.01.41.31.4
Short access day 10 total infusions0.20.40.90.30.70.10.9
Short access total infusions0.20.30.6-0.00.80.30.7
Short access day 1 locomotion0.91.52.3-1.01.40.91.5
Short access day 10 total locomotion0.31.22.0-0.71.20.81.4
Short access total locomotion1.01.52.4-0.91.41.01.5
One hour access (0.3 mA shock)6.88.09.6-2.73.12.33.1
Compulsive drug intake1.72.54.71.1-1.5-1.3-2.2
One hour access (shock baseline)3.810.013.9-2.93.22.73.7
Social response proportion0.60.71.01.0-1.0-0.8-0.5
Social responses0.20.30.40.4-0.5-0.6-0.5
Social time0.30.40.60.5-0.6-0.7-0.8
Soleus weight4.914.315.9-3.93.84.03.4
Bone: stiffness2.24.05.92.4-2.2-1.9-1.4
Tibialis anterior weight10.536.040.75.6-6.3-6.4-5.7
Time to tail flick, vehicle, before self-admin0.10.20.40.6-0.3-0.4-0.3
Time to tail flick, vehicle, after self-admin0.40.91.41.2-0.6-0.8-1.0
Time to tail flick, test, before self-admin1.31.52.4-0.91.61.21.2
Time to tail flick, test, after self-admin0.00.00.10.1-0.2-0.20.0
Delta time to tail flick, vehicle, before/after SA0.50.60.70.8-0.6-0.7-0.8
Delta time to tail flick, test, before/after SA1.11.32.10.6-1.4-1.4-1.0
Tibia length0.72.03.31.4-1.8-1.6-0.5
Ambulatory time before self-admin0.20.50.80.9-0.7-0.7-0.0
Ambulatory time after self-admin0.10.20.6-0.20.20.30.8
Bone: tissue strength0.00.00.00.2-0.1-0.0-0.0
Total heroin consumption5.66.67.32.6-2.7-2.6-2.4
Bone: trabecular number0.81.62.91.7-1.1-1.3-0.7
Bone: trabecular spacing0.40.60.9-0.90.80.80.3
Bone: trabecular thickness0.20.30.5-0.10.70.60.7
Bone: trabecular tissue density4.27.48.3-2.92.62.62.8
Water consumed over 24 hours0.71.41.81.2-1.2-1.1-1.3
Number of responses in last shaping day0.00.00.0-0.20.10.0-0.1