Hub : Genes

Sart1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Sart1	0.04	0.03	6.4e-04	0.03	0.02	0.02	0.02	3.8e-04	2.7e-03	1.9e-03	1.2e-03
2	PL	gene expression	Sart1	0.05	0.03	2.0e-05	0.05	0.04	0.04	0.04	4.3e-06	2.3e-05	5.0e-05	1.9e-05
3	LHb	gene expression	Sart1	0.16	0.11	4.7e-03	0.08	0.1	0.08	0.04	6.8e-03	3.0e-03	5.4e-03	4.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.3	0.4	0.7	-0.5	-0.8	-0.6
Area under the delay curve	0.3	0.3	0.9	0.2	0.3	-0.9
BMI with tail	1.6	5.3	8.1	-2.8	-2.8	0.4
BMI without tail	0.7	1.5	2.8	-1.7	-1.3	0.1
Body weight	3.4	14.3	17.4	-4.2	-4.1	2.9
Weight adjusted by age	2.6	2.9	3.3	-1.5	-1.8	1.8
Bone surface	3.3	5.8	8.0	-2.7	-2.8	1.4
Bone volume	0.9	1.6	2.7	-1.4	-1.6	0.4
Breakpoint value in progressive ratio session	3.6	3.9	4.6	-1.9	-2.1	1.9
Number of licking bursts	0.3	0.4	0.4	-0.6	-0.7	0.5
Context. condit. distance diff. score	2.1	2.5	2.9	1.4	1.7	-1.6
Locomotion velocity, session 1	0.0	0.0	0.1	-0.2	-0.1	0.3
Locomotion distance, session 1	0.4	0.5	0.8	-0.7	-0.9	-0.1
Locomotion velocity, session 2	3.0	3.4	4.8	-2.2	-2.0	1.3
Locomotion distance, session 2	0.5	0.8	1.3	-1.0	-1.1	0.2
Locomotion velocity, session 3	0.2	0.3	0.6	0.5	0.2	-0.8
Locomotion distance, session 3	0.0	0.0	0.0	0.1	0.1	-0.2
Stereotopy head waving bouts, day 3	1.1	1.3	1.8	0.9	1.1	-1.4
Stereotopy head waving duration, day 3	1.3	1.5	1.9	1.0	1.3	-1.4
Locomotion velocity, session 7	0.7	0.8	1.8	0.7	0.4	-1.3
Locomotion distance, session 7	0.1	0.2	0.4	0.4	0.0	-0.6
Stereotopy head waving bouts, day 7	0.3	0.4	0.6	0.5	0.5	-0.7
Stereotopy head waving duration, day 7	0.5	0.6	1.0	-1.0	-0.9	0.3
Locomotion velocity, session 8	1.2	1.4	1.5	-1.2	-1.2	1.2
Locomotion distance, session 8	0.2	0.3	0.7	0.3	0.5	-0.8
Degree of sensitization distance	0.1	0.1	0.3	0.2	-0.0	-0.5
Degree of sensitization stereotypy	0.3	0.3	0.4	-0.6	-0.7	0.3
Conditioned locomotion	1.9	2.2	2.5	-1.4	-1.5	1.6
Cocaine response after cond. corrected	1.6	1.8	2.1	1.4	1.4	-1.2
Cocaine response after cond. not corrected	1.3	1.4	1.5	1.2	1.2	-1.1
Cocaine response before conditioning	0.7	0.9	1.1	-1.1	-0.9	0.8
Saline control response	3.9	5.1	6.1	-2.4	-2.5	1.9
Bone: connectivity density	1.6	2.5	4.0	-1.8	-2.0	0.5
Bone: cortical apparent density	0.3	0.4	0.4	-0.7	-0.6	0.6
Bone: cortical area	0.9	1.4	1.7	-1.0	-1.3	1.3
Bone: cortical porosity	0.1	0.1	0.1	-0.4	-0.2	-0.3
Bone: cortical porosity	0.4	0.5	0.9	-1.0	-0.6	0.2
Bone: cortical thickness	3.9	6.5	8.1	-2.2	-2.5	2.8
Bone: cortical thickness	1.0	1.1	1.9	-0.7	-1.0	1.4
Bone: cortical tissue density	0.4	0.5	0.6	-0.8	-0.6	0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.4	-0.5	0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.1	-0.2	0.1
Condit. Reinf. active responses	0.1	0.1	0.2	-0.1	-0.4	0.0
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	0.0	-0.3
Incentive salience index mean	0.2	0.3	0.5	-0.6	-0.7	0.1
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.7	-0.7	0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.5	0.3	-0.6
Condit. Reinf. active-inactive response ratio	0.7	0.7	0.9	1.0	0.7	-0.9
Condit. Reinf. active responses	0.1	0.1	0.2	0.0	-0.2	-0.5
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.6	-0.6	-0.2
Condit. Reinf. lever presses	2.3	3.2	4.3	-1.8	-2.1	1.4
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	-0.4	-0.6	-0.1
Conditioned reinforcement - actives	0.1	0.1	0.2	0.5	0.3	-0.1
Conditioned reinforcement - inactives	5.8	6.5	8.4	2.9	2.6	-2.1
Conditioned locomotion	7.4	8.8	10.9	3.3	3.2	-2.3
Patch foraging indifference point 0 sec	0.1	0.1	0.1	0.2	0.2	-0.4
Patch foraging indifference point AUC	4.2	4.8	5.3	-2.3	-2.2	2.0
Delay disc. indifference point, 0s delay	1.0	1.1	2.1	0.5	1.0	-1.4
Delay disc. indifference point, 16s delay	1.2	1.2	1.6	1.1	0.9	-1.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	0.3	0.4	-0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.3	0.3	-0.2
Delay disc. indifference point, 4s delay	0.4	0.4	0.9	0.4	0.5	-0.9
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.1	0.3	-0.7
Indifference point function ln k	9.3	12.9	15.1	3.9	3.8	-3.1
Indifference point function log k	9.3	12.9	15.1	3.9	3.8	-3.1
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.1	0.2	-0.1
Patch foraging total patch changes 12 sec	5.2	6.7	8.3	-2.8	-2.9	2.0
Patch foraging total patch changes 18 sec	0.6	0.7	1.2	-1.1	-0.9	0.4
Patch foraging total patch changes 24 sec	3.3	4.0	4.6	-2.1	-2.0	1.9
Patch foraging total patch changes 6 sec	1.1	1.6	2.4	-1.3	-1.6	0.8
Patch foraging time to switch 0 sec	1.3	1.9	2.9	-1.6	-1.7	0.5
Patch foraging water rate 0 sec	3.2	5.1	7.1	2.6	2.7	-1.2
Patch foraging water rate 12 sec	7.5	11.5	15.2	3.8	3.9	-2.2
Patch foraging water rate 18 sec	2.8	3.7	4.6	2.2	2.0	-1.5
Patch foraging water rate 24 sec	3.5	4.9	6.7	2.4	2.6	-1.4
Patch foraging water rate 6 sec	3.1	4.5	6.4	2.5	2.4	-1.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.2	0.1	-0.6
Distance traveled before self-admin	0.5	0.5	0.7	-0.9	-0.6	0.6
Distance traveled after self-admin	0.2	0.2	0.3	-0.5	-0.4	0.5
Extensor digitorum longus weight	7.8	30.9	35.5	-5.8	-6.0	4.8
Bone: elastic displacement	0.8	0.9	1.7	1.3	1.0	-0.1
Bone: elastic work	1.0	1.2	1.9	-0.8	-1.1	1.4
Bone: endosteal estimation	1.3	2.8	4.2	1.4	1.4	-2.0
Bone: endosteal perimeter	1.5	3.2	4.9	1.6	1.5	-2.2
Epididymis fat weight	3.1	7.1	7.9	2.5	2.8	-2.7
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.0	-0.2	0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.2	-0.2	0.4
Diff in mean of infusions in LGA sessions	0.6	0.6	0.9	-0.6	-0.8	1.0
Delay discount exponential model param	0.2	0.2	0.6	-0.1	-0.3	0.8
Extinction: sum of active levers before priming	4.3	4.2	5.2	-2.2	-2.3	1.6
Active lever presses in extinction session 6	3.5	3.4	4.4	-1.7	-1.7	2.1
Bone: final force	3.0	4.8	5.8	-2.4	-2.3	1.8
Bone: final moment	2.6	4.2	4.9	-2.2	-2.2	1.7
Food consumed during 24 hour testing period	0.1	0.2	0.4	-0.3	-0.2	0.6
Glucose	2.8	4.2	5.9	1.8	1.9	-2.4
Heart weight	3.9	5.6	5.7	2.3	2.4	-2.4
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.1	-0.2	0.7
Intermittent access intake day 1-15 change	0.4	0.4	0.7	0.8	0.6	0.1
Intermittent access intake escalation	0.4	0.4	0.7	0.8	0.6	-0.2
Intermittent access intake escalation 2	0.1	0.1	0.1	0.4	0.4	0.4
Intermitt. access day 1 inactive lever presses	2.5	2.7	3.2	1.8	1.7	-1.4
Intermitt. access day 15 inactive lever presses	2.1	2.3	3.7	1.9	1.3	-1.3
Intermitt. access escalation Index	4.5	4.0	5.3	1.8	1.8	-2.3
Intermittent access day 1 total infusions	7.0	8.1	12.0	2.6	2.4	-3.5
Intermittent access day 15 total infusions	8.3	9.3	10.7	3.3	2.8	-3.0
Intermittent access terminal intake (last 3 days)	5.8	6.4	7.0	2.7	2.3	-2.6
Intermittent access total infusions	5.3	5.9	7.9	2.4	1.9	-2.8
Intermittent access day 1 locomotion	5.1	5.4	8.6	2.1	1.8	-2.9
Intermittent access day 15 total locomotion	5.1	5.5	6.4	2.5	2.1	-2.4
Intermittent access total locomotion	7.5	8.6	11.7	2.8	2.5	-3.4
Intermittent access standard deviation	0.9	1.0	1.5	1.2	1.0	-0.6
Left kidney weight	0.5	1.5	2.1	1.3	1.5	-0.9
Right kidney weight	0.1	0.1	0.3	0.3	0.5	0.3
Cocaine induced anxiety	0.0	0.0	0.1	-0.0	0.1	0.2
Post-drug Anxiety	1.6	1.8	2.8	-1.2	-1.1	1.7
Baseline Anxiety	3.0	3.2	3.6	-1.6	-1.8	1.9
Tail length	1.0	3.1	5.1	-1.5	-1.3	2.3
Length with tail	2.7	10.0	12.1	-3.0	-3.0	3.5
Length without tail	2.9	6.4	7.4	-2.3	-2.7	2.5
Times rat made contact with spout	0.3	0.4	0.6	-0.7	-0.7	0.3
Lifetime Intake	4.7	5.4	7.7	2.3	1.8	-2.8
Liver weight, left	0.1	0.1	0.2	0.3	0.4	-0.2
Liver weight, right	0.1	0.1	0.1	0.4	0.3	-0.2
Locomotor activity	1.3	2.0	3.0	1.7	1.6	-0.8
Locomotor testing distance	1.9	3.2	4.4	2.1	2.0	-1.1
Locomotor testing rearing	2.2	3.4	4.0	2.0	1.9	-1.6
Locomotion in novel chamber	4.4	5.4	6.2	2.5	2.4	-2.0
Locomotion in novel chamber post-restriction	2.8	3.4	4.0	2.0	1.9	-1.7
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.2	-0.0	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.1	-0.0	-0.4
Time >=10cm from walls, locomotor time 1	1.2	1.2	2.3	0.8	0.9	-1.5
Bouts of movement, locomotor time 1	1.6	1.8	1.8	-1.4	-1.3	1.3
Total resting periods, locomotor time 1	1.1	1.2	1.3	-1.1	-1.1	1.0
Rest time, locomotor task time 1	1.1	1.2	1.8	1.2	1.3	-0.7
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.2	-0.5	-0.3
Vertical activity count, locomotor time 1	1.3	1.4	1.9	1.4	1.1	-1.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.3	-0.0	-0.0
Bouts of movement, locomotor time 2	0.5	0.5	0.7	-0.7	-0.8	0.6
Total resting periods, locomotor time 2	0.2	0.2	0.3	-0.5	-0.6	0.3
Rest time, locomotor task time 2	2.5	2.9	3.6	1.6	1.9	-1.6
Distance moved, locomotor task time 2	1.4	1.6	1.9	-1.2	-1.4	1.2
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.2	-0.1	0.8
Light reinforcement 1	0.1	0.2	0.3	0.3	0.6	-0.3
Light reinforcement 2	0.7	0.9	1.5	1.0	1.2	-0.6
Bone: marrow area	1.4	2.9	4.5	1.4	1.5	-2.1
Bone: maximum diameter	0.2	0.3	0.5	-0.5	-0.5	0.7
Bone: maximum force	3.0	5.1	6.8	-2.5	-2.6	1.4
Bone: maximum moment	2.5	4.3	5.9	-2.3	-2.4	1.3
Mean time between licks in bursts	0.4	0.6	0.6	-0.8	-0.8	0.8
Mean num. licks in bursts	0.2	0.3	0.4	0.5	0.5	-0.6
Cd content in liver	1.0	1.1	1.5	1.1	1.2	-0.6
Co content in liver	1.0	1.2	2.0	1.1	1.4	-0.5
Cu content in liver	0.2	0.3	0.5	-0.5	-0.7	0.3
Fe content in liver	0.1	0.2	0.3	-0.3	-0.4	0.6
K content in liver	1.3	1.3	2.1	-1.3	-1.5	0.5
Mg content in liver	0.3	0.3	0.8	-0.2	-0.4	-0.9
Mn content in liver	2.8	3.2	3.8	-1.8	-1.9	1.6
Na content in liver	1.5	1.6	2.1	-1.2	-1.1	1.4
Rb content in liver	2.2	2.7	4.0	1.6	1.3	-2.0
Se content in liver	0.0	0.0	0.1	0.1	-0.2	-0.2
Sr content in liver	4.1	3.8	4.6	-1.9	-1.7	2.1
Zn content in liver	1.1	1.2	1.5	-1.2	-1.2	0.8
Bone: minimum diameter	1.3	2.4	4.4	1.3	1.1	-2.1
Time in familiar zone, hab. session 1	0.4	0.4	0.5	0.7	0.4	-0.7
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.2	0.5	0.0
Total zone transitions, hab. session 1	0.7	0.9	1.5	-0.9	-1.2	0.7
Total locomotion distance, hab. session 1	0.4	0.6	0.8	0.7	0.7	-0.9
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.2	0.2	-0.4
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.2	0.0	0.3
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	-0.2	-0.3
Total zone transitions, hab. session 2	0.9	1.2	1.8	-1.4	-1.3	-0.2
Total locomotion distance, hab. session 2	0.3	0.4	1.2	0.0	0.2	-1.1
Locomotion velocity, hab. session 2	0.4	0.6	1.5	0.2	0.4	-1.2
Novel to familiar place preference ratio	0.8	0.8	1.1	-1.0	-1.0	0.7
Novelty place preference	0.3	0.3	0.4	-0.6	-0.6	0.3
Time in novel zone, NPP test	0.2	0.2	0.3	-0.5	-0.5	0.2
Total zone transitions, NPP test	2.0	2.8	4.0	-2.0	-1.8	1.0
Total locomotion distance, NPP test	0.0	0.1	0.1	-0.3	-0.1	-0.3
Locomotion velocity, NPP test	0.0	0.1	0.1	-0.3	-0.2	-0.2
Intraocular pressure	0.6	0.8	1.6	1.0	1.2	-0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.2	0.0	0.0
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.1	-0.0	0.1
Parametrial fat weight	3.2	6.3	7.7	2.2	2.6	-2.8
Pavlov. Cond. lever latency	0.2	0.2	0.4	0.7	0.5	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	-0.3	-0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	-0.1	-0.1
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.2	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	-0.1	-0.0
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	0.0	-0.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.5	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	0.8	0.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	-0.6	-0.5	0.3
Pavlov. Cond. response bias	0.1	0.1	0.1	-0.3	-0.3	0.3
Pavlov. Cond. lever latency	0.5	0.7	0.9	0.9	0.9	-0.7
Pavlov. Cond. magazine entry latency	3.4	3.9	5.7	-2.0	-2.4	1.5
Pavlov. Cond. change in total contacts	1.8	2.4	3.4	-1.6	-1.8	1.1
Pavlov. Cond. index score	2.4	3.1	4.3	-1.8	-2.1	1.4
Pavlov. Cond. latency score	2.0	2.5	3.5	-1.6	-1.9	1.2
Pavlov. Cond. lever contacts	0.7	0.9	1.0	-0.9	-0.9	1.0
Pavlov. Cond. magazine entry number	6.3	7.6	10.2	2.8	3.2	-2.2
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.1	1.1	1.4	-1.1
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.8	5.1	-2.0	-2.3	1.5
Pavlov. Cond. response bias	2.0	2.7	3.2	-1.7	-1.8	1.4
Time in closed arm before self-admin	0.0	0.0	0.1	-0.2	0.0	-0.0
Time in closed arm after self-admin	0.0	0.0	0.1	0.3	0.1	-0.2
Time in open arm before self-admin	0.5	0.5	0.6	0.8	0.7	-0.8
Time in open arm after self-admin	0.1	0.1	0.2	0.4	0.4	-0.0
Bone: periosteal estimation	0.0	0.1	0.1	0.2	0.0	-0.3
Bone: periosteal perimeter	0.0	0.1	0.2	-0.2	-0.4	-0.0
Bone: post-yield work	0.7	0.9	1.9	-0.7	-0.6	-1.4
Progressive ratio test 1 active lever presses	2.9	3.1	3.6	1.9	1.6	-1.8
Progressive ratio test 1 breakpoint	2.5	2.6	3.3	1.8	1.5	-1.6
Progressive ratio test 1 inactive lever presses	1.4	1.5	1.8	1.3	1.1	-1.3
Progressive ratio test 2 active lever presses	4.1	4.5	5.6	2.4	1.8	-2.1
Progressive ratio test 2 breakpoint	4.9	5.5	7.4	2.7	2.2	-2.1
Progressive ratio test 2 inactive lever presses	9.3	10.7	11.8	3.4	3.1	-3.3
Incentive Sensitization - Responses	0.4	0.4	0.6	0.8	0.3	-0.7
Incentive Sensitization - Breakpoint	0.6	0.6	0.9	1.0	0.5	-0.8
Sum of active levers in priming session hrs 5-6	3.0	2.9	5.0	-1.2	-1.5	2.2
Progressive ratio	1.4	1.6	2.9	-1.7	-1.4	0.2
Food seeking constrained by brief footshock	0.2	0.2	0.3	-0.3	-0.6	0.5
Seeking ratio, punishment vs. effort	1.2	1.5	2.7	1.6	1.3	-0.4
Retroperitoneal fat weight	6.1	20.1	21.3	4.6	4.5	-4.3
Reaction time number correct	0.5	0.7	1.2	-0.8	-0.6	1.1
Reaction time mean minus median	3.1	4.0	4.5	-2.1	-2.1	1.8
Reaction time mean minus median AUC	2.0	2.6	2.8	-1.6	-1.6	1.7
Reaction time num false alarms	0.2	0.2	0.5	0.7	0.4	-0.1
Reaction time num false alarms AUC	0.1	0.1	0.3	-0.0	-0.3	0.5
Reaction time trials correct on left	0.5	0.7	1.2	-0.8	-0.6	1.1
Reaction time trials on left	0.7	0.9	1.5	-0.9	-0.7	1.2
Reaction time mean	0.0	0.0	0.1	-0.3	-0.2	0.2
Reaction time mean AUC	0.0	0.0	0.0	-0.2	-0.1	0.1
Median of all reaction times	0.1	0.1	0.1	0.2	0.3	-0.3
Reaction time omissions	1.4	1.9	2.1	-1.3	-1.4	1.4
Reaction time false alarm rate	0.1	0.2	0.4	0.7	0.4	-0.2
Reaction time premature initiation rate	2.5	3.4	3.6	-1.9	-1.8	1.8
Reaction time premature initiations	4.5	6.3	7.1	-2.5	-2.4	2.7
Std. dev. reaction times	0.8	1.2	1.4	-1.2	-1.1	1.0
Reaction time trials completed	0.7	0.9	1.5	-0.9	-0.7	1.2
Reaction time trials AUC	0.4	0.6	1.0	-0.6	-0.5	1.0
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.6	-0.7	-0.4
Run reversals in cocaine runway, males	0.3	0.3	0.4	0.5	0.4	0.6
Latency to leave start box in cocaine runway	0.1	0.2	0.4	0.2	0.0	-0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.0	-0.1	-0.4
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.2	-0.1	-0.0
Std. dev. time between licks in bursts	0.0	0.1	0.1	0.2	0.3	0.2
Total sessions with >9 infusions	2.2	2.4	3.4	1.5	1.3	-1.8
Short access day 1 total inactive lever presses	4.2	4.7	5.2	2.3	2.0	-2.2
Short access day 10 total inactive lever presses	3.7	4.0	4.9	2.2	2.0	-1.7
Short access day 1 total infusions	4.1	4.4	7.0	1.8	1.7	-2.6
Short access day 10 total infusions	2.6	2.9	6.0	1.4	0.9	-2.5
Short access total infusions	2.0	2.3	4.3	1.3	1.0	-2.1
Short access day 1 locomotion	3.2	3.4	5.4	1.8	1.2	-2.3
Short access day 10 total locomotion	2.3	2.5	4.4	1.5	1.1	-2.1
Short access total locomotion	2.0	2.1	3.9	1.3	0.9	-2.0
One hour access (0.3 mA shock)	10.1	11.8	13.9	3.7	3.4	-3.2
Compulsive drug intake	2.8	2.9	3.2	-1.7	-1.6	1.8
One hour access (shock baseline)	8.9	10.3	12.1	3.5	3.1	-3.0
Social response proportion	0.8	0.9	1.1	-1.1	-1.0	0.7
Social responses	0.3	0.3	0.4	-0.4	-0.7	0.6
Social time	0.4	0.6	0.7	-0.7	-0.8	0.8
Soleus weight	4.2	12.2	14.2	3.7	3.8	-3.0
Bone: stiffness	2.3	3.6	4.9	-2.2	-2.2	1.0
Tibialis anterior weight	12.6	43.1	44.3	-6.6	-6.7	6.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.7	-0.6	0.2
Time to tail flick, vehicle, after self-admin	1.0	1.1	1.6	-1.3	-1.2	0.4
Time to tail flick, test, before self-admin	1.2	1.1	2.3	0.8	0.6	-1.5
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	-0.0	0.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	-0.7	-0.7	0.2
Delta time to tail flick, test, before/after SA	2.3	2.0	3.9	-1.2	-0.8	2.0
Tibia length	1.4	4.0	5.3	-1.8	-1.8	2.3
Ambulatory time before self-admin	0.4	0.4	0.4	-0.7	-0.6	0.6
Ambulatory time after self-admin	0.1	0.1	0.2	0.3	0.3	-0.5
Bone: tissue strength	0.1	0.1	0.2	-0.4	-0.2	0.0
Total heroin consumption	5.9	7.0	7.6	-2.8	-2.7	2.4
Bone: trabecular number	0.3	0.4	0.9	-0.5	-1.0	-0.2
Bone: trabecular spacing	0.1	0.2	0.4	0.3	0.6	-0.2
Bone: trabecular thickness	0.9	1.0	1.7	1.0	0.6	-1.3
Bone: trabecular tissue density	3.2	4.6	6.0	2.3	2.4	-1.5
Water consumed over 24 hours	0.8	0.9	1.1	-1.1	-1.0	0.8
Number of responses in last shaping day	1.1	1.1	1.6	1.3	1.0	-0.9