Fam124a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Fam124a	0.04	0.03	1.0e-02	0	0	0	0	2.6e-01	1.6e-01	2.3e-01	2.7e-01
2	PL	gene expression	Fam124a	0.04	0.03	2.1e-03	0.03	0.02	0.02	0.02	5.6e-04	1.4e-03	1.5e-03	9.2e-04
3	Adipose	gene expression	Fam124a	0.03	0.02	2.9e-03	0	0.01	-0	-0	3.2e-01	5.9e-02	3.7e-01	5.3e-01
4	BLA	mRNA stability	Fam124a	0.1	0.06	2.0e-04	0.08	0.05	0.06	0.08	3.7e-05	1.1e-03	5.4e-04	5.9e-05
5	pVTA	mRNA stability	Fam124a	0.1	0.06	2.4e-03	0	0.04	0.02	0.01	2.5e-01	1.1e-02	4.0e-02	1.1e-01
6	Brain	mRNA stability	Fam124a	0.04	0.03	4.1e-03	0.01	0.02	0.01	0.01	5.0e-02	4.6e-03	3.9e-02	5.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	0.9	0.4	0.2	-0.9	-0.2	0.9	0.6
Area under the delay curve	4.1	4.3	6.2	-2.2	-1.8	2.3	1.8	-1.8	-2.5
BMI with tail	0.3	1.0	2.4	-0.6	-0.7	1.5	0.8	-1.5	-0.3
BMI without tail	0.1	0.1	0.3	0.5	0.3	-0.1	-0.2	-0.3	0.5
Body weight	0.7	2.9	3.8	-1.9	-1.6	1.8	1.7	-1.5	-1.6
Weight adjusted by age	1.1	1.3	2.0	-1.2	-1.4	1.0	1.4	-1.0	-0.4
Bone surface	0.2	0.4	0.9	0.3	0.3	-0.9	-0.3	1.0	0.5
Bone volume	0.1	0.1	0.4	0.2	0.1	-0.5	-0.1	0.6	0.3
Breakpoint value in progressive ratio session	0.1	0.1	0.1	-0.1	-0.3	0.2	0.3	-0.2	-0.3
Number of licking bursts	0.3	0.3	0.7	-0.1	-0.6	0.7	0.6	-0.8	-0.0
Context. condit. distance diff. score	0.1	0.1	0.3	0.3	0.4	-0.1	-0.4	0.1	-0.5
Locomotion velocity, session 1	0.9	0.9	1.3	-1.1	-1.0	1.0	1.0	-1.0	-0.5
Locomotion distance, session 1	0.7	0.9	1.5	-1.1	-1.2	0.7	1.2	-0.8	-0.4
Locomotion velocity, session 2	0.4	0.5	0.7	-0.9	-0.7	0.6	0.7	-0.4	-0.8
Locomotion distance, session 2	0.1	0.1	0.3	-0.3	-0.5	-0.3	0.5	0.2	0.3
Locomotion velocity, session 3	0.9	1.1	2.0	-1.0	-1.3	0.8	1.4	-0.8	-0.6
Locomotion distance, session 3	1.3	1.5	2.1	-1.1	-1.4	1.2	1.5	-1.2	-0.9
Stereotopy head waving bouts, day 3	0.8	1.0	1.4	1.0	1.0	-1.2	-1.0	1.1	0.7
Stereotopy head waving duration, day 3	0.0	0.1	0.1	-0.3	-0.3	0.1	0.3	-0.1	-0.1
Locomotion velocity, session 7	0.1	0.1	0.2	0.5	-0.1	-0.1	0.1	-0.2	0.5
Locomotion distance, session 7	1.3	1.6	2.4	1.5	1.2	-1.4	-1.1	1.2	1.1
Stereotopy head waving bouts, day 7	2.5	2.8	3.6	-1.7	-1.9	1.7	1.8	-1.7	-1.1
Stereotopy head waving duration, day 7	3.8	4.6	5.6	-2.2	-2.4	2.2	2.3	-2.1	-1.6
Locomotion velocity, session 8	0.7	0.8	2.0	-1.1	-0.7	0.7	0.7	-0.4	-1.4
Locomotion distance, session 8	0.1	0.2	0.4	-0.5	-0.4	0.1	0.4	-0.0	-0.7
Degree of sensitization distance	6.8	6.8	8.4	2.9	2.7	-2.6	-2.7	2.4	2.3
Degree of sensitization stereotypy	3.2	3.5	4.6	-2.2	-1.9	1.9	1.8	-1.7	-1.7
Conditioned locomotion	0.6	0.7	1.7	-0.1	0.8	-0.5	-0.8	1.1	-1.3
Cocaine response after cond. corrected	0.3	0.3	0.6	0.5	0.7	0.4	-0.7	-0.4	-0.4
Cocaine response after cond. not corrected	0.2	0.2	0.4	0.4	0.7	0.3	-0.6	-0.3	-0.4
Cocaine response before conditioning	0.3	0.3	0.7	-0.7	-0.8	0.2	0.8	-0.1	-0.2
Saline control response	0.3	0.4	1.2	-0.2	0.3	-0.8	-0.3	1.1	-0.3
Bone: connectivity density	1.0	1.5	3.1	0.7	1.0	-1.7	-1.0	1.7	0.9
Bone: cortical apparent density	0.9	1.1	2.7	-0.4	-1.1	1.3	1.0	-1.6	-0.4
Bone: cortical area	0.1	0.1	0.4	0.1	-0.1	0.6	0.1	-0.6	-0.2
Bone: cortical porosity	2.1	2.3	5.0	-2.0	-1.3	1.0	1.3	-0.4	-2.2
Bone: cortical porosity	2.0	2.2	4.8	-2.0	-1.3	1.0	1.3	-0.4	-2.2
Bone: cortical thickness	0.4	0.7	1.4	-0.5	-0.6	1.2	0.6	-1.1	-0.6
Bone: cortical thickness	1.5	1.7	3.1	-0.9	-0.9	1.7	1.0	-1.8	-1.2
Bone: cortical tissue density	0.8	1.1	2.7	-0.3	-1.0	1.3	1.0	-1.6	-0.3
Condit. Reinf. active minus inactive responses	0.9	1.0	1.5	-1.1	-1.2	0.8	1.2	-0.9	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.6	0.3	-0.0	-0.1	0.0	-0.2	0.8
Condit. Reinf. active responses	1.7	2.1	3.4	-1.8	-1.6	1.3	1.6	-1.2	-0.8
Condit. Reinf. inactive responses	1.5	1.7	3.4	-1.8	-1.3	1.0	1.3	-0.6	-1.5
Incentive salience index mean	2.1	2.5	3.5	-1.9	-1.8	1.6	1.8	-1.5	-0.7
Condit. Reinf. lever presses	2.6	3.4	5.0	-2.2	-1.9	2.0	1.9	-1.7	-1.2
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.4	-0.4	0.5	0.4	-0.6	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	-0.4	-0.8	0.7	0.8	-0.9	0.2
Condit. Reinf. active responses	0.4	0.5	0.6	-0.8	-0.7	0.7	0.7	-0.8	-0.5
Condit. Reinf. inactive responses	0.4	0.5	1.0	0.3	0.8	-0.8	-0.8	1.0	-0.1
Condit. Reinf. lever presses	2.0	2.8	4.3	-1.9	-2.1	1.3	2.1	-1.4	-0.7
Condit. Reinf. lever reinforcers received	0.5	0.8	0.9	-1.0	-0.9	0.9	0.9	-0.9	-0.6
Conditioned reinforcement - actives	8.6	8.6	12.0	2.7	3.5	-3.0	-3.3	3.0	1.9
Conditioned reinforcement - inactives	4.1	4.6	5.8	2.1	2.1	-2.4	-2.1	2.1	2.0
Conditioned locomotion	3.0	3.6	6.4	1.8	2.5	-1.6	-2.4	1.7	0.6
Patch foraging indifference point 0 sec	0.1	0.1	0.4	0.0	0.0	-0.4	0.1	0.6	0.0
Patch foraging indifference point AUC	0.4	0.5	1.3	0.7	-0.4	0.5	0.3	-1.1	0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.5	-0.4	0.4	0.4	-0.1	-0.8
Delay disc. indifference point, 16s delay	1.6	1.7	3.7	-1.3	-1.0	1.3	1.0	-0.9	-1.9
Delay disc. indifference point, 2s delay	1.9	2.1	2.7	-1.6	-1.5	1.4	1.4	-1.0	-1.6
Delay disc. indifference point, 24s delay	0.9	0.8	1.5	-0.8	-0.7	1.2	0.7	-1.1	-1.0
Delay disc. indifference point, 4s delay	4.4	4.7	6.2	-2.5	-2.0	2.3	1.8	-1.8	-2.5
Delay disc. indifference point, 8s delay	3.3	3.4	4.9	-1.8	-1.6	2.2	1.6	-1.8	-2.0
Indifference point function ln k	0.5	0.6	1.6	-1.3	-0.5	0.6	0.6	0.0	-1.2
Indifference point function log k	0.5	0.6	1.6	-1.3	-0.5	0.6	0.6	0.0	-1.2
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.4	-0.4	0.1	0.5	0.2	-0.5
Patch foraging total patch changes 12 sec	0.3	0.4	0.7	-0.2	-0.8	0.5	0.8	-0.8	0.3
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	-0.2	-0.5	0.5	0.4	-0.7	-0.4
Patch foraging total patch changes 24 sec	0.6	0.7	1.3	-0.8	-1.1	0.7	1.0	-0.7	-0.8
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	0.5	-0.1	0.0	0.1	-0.3	0.6
Patch foraging time to switch 0 sec	0.2	0.4	0.7	0.2	0.7	-0.7	-0.7	0.8	-0.1
Patch foraging water rate 0 sec	1.0	1.6	1.9	-1.4	-1.3	1.4	1.3	-1.2	-1.1
Patch foraging water rate 12 sec	3.2	4.9	7.4	-2.7	-2.2	2.0	2.2	-1.6	-2.4
Patch foraging water rate 18 sec	6.9	9.3	10.6	-3.1	-3.2	3.3	3.1	-3.0	-2.6
Patch foraging water rate 24 sec	1.3	1.8	3.0	-1.7	-1.2	1.2	1.2	-0.8	-1.7
Patch foraging water rate 6 sec	2.8	4.1	5.6	-2.4	-1.9	1.9	1.9	-1.5	-2.3
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	3.3	0.5	1.8	-0.9	-1.7	1.5	-0.1
Distance traveled before self-admin	0.1	0.1	0.3	-0.4	-0.2	-0.2	0.1	0.5	-0.5
Distance traveled after self-admin	0.5	0.6	1.2	0.1	0.9	-0.7	-1.0	1.1	-0.4
Extensor digitorum longus weight	7.5	29.5	32.9	-5.5	-5.6	5.7	5.5	-5.1	-5.2
Bone: elastic displacement	0.4	0.5	0.9	-0.1	0.7	-0.7	-0.7	0.9	-0.5
Bone: elastic work	0.3	0.3	0.7	-0.9	-0.6	0.2	0.6	0.1	-0.8
Bone: endosteal estimation	0.3	0.7	1.3	0.7	0.6	-1.0	-0.6	1.1	0.7
Bone: endosteal perimeter	0.8	1.7	2.7	1.0	1.3	-1.5	-1.3	1.6	0.8
Epididymis fat weight	0.2	0.4	1.0	-0.3	0.4	-0.5	-0.4	1.0	-1.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.0	-0.2	-0.1	0.4	0.3	-0.4
Delta time in open arm before/after self-admin	4.7	4.5	7.2	2.5	2.1	-1.6	-2.3	1.1	2.7
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	-0.4	-0.5	0.1	0.6	0.2	-0.7
Delay discount exponential model param	5.1	5.4	6.8	2.4	2.1	-2.6	-2.0	2.1	2.6
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.4	0.3	-0.4	-0.3	0.3	0.2
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.1	-0.0	-0.5	0.0	0.6	-0.3
Bone: final force	1.0	1.6	2.2	-1.2	-1.5	1.2	1.5	-0.9	-1.3
Bone: final moment	1.2	1.9	2.7	-1.4	-1.6	1.2	1.6	-0.8	-1.4
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.3	-0.4	0.2	0.4	-0.3	0.2
Glucose	0.5	0.7	1.5	-0.1	-1.0	0.9	1.0	-1.2	0.3
Heart weight	0.1	0.2	0.4	-0.2	-0.3	0.6	0.3	-0.7	0.2
Delay discount hyperbolic model param	5.3	5.6	7.2	2.5	2.2	-2.6	-2.1	2.1	2.7
Intermittent access intake day 1-15 change	1.3	1.2	2.6	0.8	0.9	-1.5	-0.8	1.6	0.6
Intermittent access intake escalation	1.6	1.5	2.8	1.0	1.1	-1.6	-1.0	1.7	0.7
Intermittent access intake escalation 2	0.7	0.7	1.1	0.8	0.7	-1.1	-0.6	0.9	0.8
Intermitt. access day 1 inactive lever presses	5.4	5.8	8.5	2.9	2.2	-2.3	-2.3	1.8	2.8
Intermitt. access day 15 inactive lever presses	1.5	1.7	2.4	1.2	1.0	-1.6	-1.1	1.5	1.2
Intermitt. access escalation Index	0.4	0.4	1.0	0.2	-0.6	0.5	0.6	-1.0	0.4
Intermittent access day 1 total infusions	0.2	0.2	0.4	0.6	0.6	-0.4	-0.4	0.4	-0.1
Intermittent access day 15 total infusions	2.3	2.6	3.4	1.7	1.6	-1.9	-1.4	1.8	1.0
Intermittent access terminal intake (last 3 days)	1.7	1.9	2.7	1.6	1.4	-1.6	-1.2	1.4	0.9
Intermittent access total infusions	2.4	2.7	3.7	1.9	1.8	-1.6	-1.6	1.6	1.0
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.3	0.5	0.0	-0.3	0.0	-0.1
Intermittent access day 15 total locomotion	1.7	1.8	2.4	1.3	1.5	-1.4	-1.5	1.5	0.5
Intermittent access total locomotion	1.0	1.2	1.7	1.2	1.3	-1.0	-1.2	1.1	0.5
Intermittent access standard deviation	1.1	1.2	3.1	0.5	0.9	-1.5	-0.8	1.8	0.1
Left kidney weight	1.9	5.4	7.2	-2.7	-2.6	2.3	2.6	-2.1	-1.5
Right kidney weight	2.9	8.1	10.6	-3.2	-3.1	2.8	3.1	-2.5	-2.1
Cocaine induced anxiety	0.4	0.5	0.9	-1.0	-0.7	0.4	0.7	-0.1	-0.9
Post-drug Anxiety	0.2	0.2	0.5	-0.4	-0.2	-0.5	0.3	0.7	0.1
Baseline Anxiety	0.2	0.2	0.3	0.2	0.4	-0.5	-0.4	0.5	0.5
Tail length	0.1	0.3	0.6	-0.7	-0.2	-0.5	0.1	0.7	-0.8
Length with tail	0.2	0.9	2.2	-1.4	-0.7	0.1	0.7	0.4	-1.5
Length without tail	0.7	1.6	2.7	-1.7	-1.2	1.2	1.3	-0.6	-1.5
Times rat made contact with spout	0.4	0.5	1.1	-0.6	-1.1	0.3	1.1	-0.3	-0.2
Lifetime Intake	2.6	3.0	4.1	2.0	2.0	-1.7	-1.8	1.7	1.0
Liver weight, left	4.0	6.4	8.9	-2.4	-3.0	2.5	3.0	-2.4	-1.7
Liver weight, right	0.1	0.2	0.4	-0.5	-0.4	0.6	0.4	-0.4	-0.6
Locomotor activity	3.3	5.2	8.1	-2.8	-2.5	2.0	2.4	-1.5	-2.3
Locomotor testing distance	0.5	0.8	1.8	-1.3	-1.1	0.2	0.9	0.2	-1.0
Locomotor testing rearing	0.2	0.4	0.7	-0.3	-0.3	-0.8	0.2	0.8	0.8
Locomotion in novel chamber	1.1	1.4	1.9	-1.4	-1.3	1.2	0.9	-1.0	-1.2
Locomotion in novel chamber post-restriction	0.2	0.2	0.9	-0.6	-0.0	0.1	0.0	0.3	-1.0
Fecal boli incidents, locomotor time 1	2.4	2.7	4.6	-1.2	-1.7	1.9	1.7	-2.1	-0.6
Change in fecal boli incidents, locomotor task	1.4	1.3	2.3	0.9	1.1	-1.3	-1.3	1.5	0.6
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	-0.6	-0.6	-0.4	0.7	0.6	-0.2
Bouts of movement, locomotor time 1	0.5	0.6	0.9	-0.6	-0.8	0.9	0.9	-0.9	-0.2
Total resting periods, locomotor time 1	0.5	0.6	1.1	-0.4	-0.7	0.9	0.8	-1.1	-0.1
Rest time, locomotor task time 1	2.6	2.9	6.7	-0.9	-1.6	2.1	1.7	-2.6	-0.0
Distance moved, locomotor task time 1	1.5	1.6	4.1	0.6	1.1	-1.7	-1.1	2.0	-0.1
Vertical activity count, locomotor time 1	1.4	1.5	3.8	-0.0	1.0	-1.4	-1.0	2.0	-1.0
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.3	-0.4	-0.4	-0.8	0.4	1.2	-0.5
Bouts of movement, locomotor time 2	0.3	0.3	1.0	-0.1	-0.2	1.0	0.2	-1.0	-0.2
Total resting periods, locomotor time 2	0.7	0.7	1.9	-0.2	-0.5	1.3	0.5	-1.4	-0.1
Rest time, locomotor task time 2	2.5	2.9	6.7	-0.8	-1.7	2.2	1.6	-2.6	-0.1
Distance moved, locomotor task time 2	0.6	0.7	2.2	-0.2	0.3	-1.1	-0.2	1.5	-0.7
Vertical activity count, locomotor time 2	1.1	1.2	2.7	-0.4	0.9	-1.0	-0.7	1.7	-1.4
Light reinforcement 1	0.3	0.6	0.9	-0.9	-0.8	0.5	0.8	-0.4	-0.8
Light reinforcement 2	0.5	0.7	1.2	0.7	1.1	-0.7	-1.1	0.9	-0.1
Bone: marrow area	0.4	0.8	1.4	0.8	0.7	-1.1	-0.7	1.2	0.7
Bone: maximum diameter	0.3	0.6	1.1	0.9	1.0	-0.4	-1.0	0.5	0.2
Bone: maximum force	0.9	1.5	2.3	-1.2	-1.4	1.0	1.4	-0.6	-1.5
Bone: maximum moment	1.1	1.9	2.5	-1.5	-1.6	1.1	1.6	-0.6	-1.6
Mean time between licks in bursts	1.3	1.8	3.9	1.7	1.0	-1.3	-1.0	0.7	2.0
Mean num. licks in bursts	0.0	0.1	0.1	-0.3	-0.1	-0.3	0.1	0.3	-0.1
Cd content in liver	1.0	1.1	2.0	1.1	0.9	-1.0	-0.9	0.8	1.4
Co content in liver	0.7	0.8	1.3	-0.7	-0.8	1.1	0.7	-0.9	-1.1
Cu content in liver	0.9	1.1	1.9	-0.8	-1.4	1.0	1.4	-1.2	-0.0
Fe content in liver	0.4	0.5	1.1	0.7	0.4	-0.8	-0.4	0.5	1.0
K content in liver	0.1	0.1	0.5	0.1	0.0	-0.1	0.0	0.2	-0.7
Mg content in liver	0.7	0.7	1.0	0.9	0.9	-1.0	-0.8	1.0	0.1
Mn content in liver	0.5	0.6	1.0	0.7	0.8	-0.9	-0.7	1.0	0.0
Na content in liver	2.9	3.1	4.8	-2.0	-2.1	1.3	2.2	-1.0	-1.5
Rb content in liver	3.3	4.0	6.0	1.8	2.1	-2.3	-2.1	2.5	0.9
Se content in liver	2.2	2.6	4.0	1.4	1.7	-1.8	-1.7	2.0	1.0
Sr content in liver	1.3	1.2	3.9	1.2	0.7	-1.0	-0.7	0.4	2.0
Zn content in liver	1.2	1.3	2.2	-1.5	-1.3	0.8	1.3	-0.4	-1.3
Bone: minimum diameter	0.0	0.1	0.1	0.4	0.3	-0.2	-0.3	0.3	0.2
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.4	-0.4	0.6	0.4	-0.6	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.6	0.3	-0.4	-0.3	0.4	0.3
Total zone transitions, hab. session 1	0.7	1.0	1.3	-0.8	-1.1	1.1	1.1	-1.1	-0.7
Total locomotion distance, hab. session 1	0.2	0.2	0.5	-0.3	-0.7	0.3	0.7	-0.2	-0.4
Locomotion velocity, hab. session 1	0.3	0.4	0.7	-0.7	-0.9	0.3	0.9	-0.1	-0.7
Time in familiar zone, hab. session 2	0.4	0.4	0.7	-0.0	0.7	-0.5	-0.7	0.9	-0.6
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.1	-0.5	0.3	0.5	-0.5	0.6
Total zone transitions, hab. session 2	2.3	2.9	3.7	-1.9	-1.9	1.5	1.9	-1.2	-1.7
Total locomotion distance, hab. session 2	1.6	2.2	2.9	-1.6	-1.6	1.2	1.6	-1.0	-1.7
Locomotion velocity, hab. session 2	1.9	2.5	3.2	-1.7	-1.8	1.4	1.8	-1.1	-1.7
Novel to familiar place preference ratio	1.6	1.7	1.9	1.3	1.3	-1.4	-1.3	1.3	1.2
Novelty place preference	1.5	1.6	1.9	1.1	1.2	-1.4	-1.3	1.4	1.1
Time in novel zone, NPP test	1.5	1.5	1.9	1.1	1.2	-1.4	-1.2	1.4	1.1
Total zone transitions, NPP test	1.0	1.4	2.0	-1.3	-1.4	1.1	1.4	-1.0	-0.8
Total locomotion distance, NPP test	0.1	0.2	0.7	0.4	-0.2	-0.4	0.2	0.2	0.9
Locomotion velocity, NPP test	0.1	0.2	0.5	0.3	-0.4	-0.3	0.4	-0.0	0.7
Intraocular pressure	2.6	3.6	5.4	1.3	1.9	-2.3	-2.0	2.2	1.5
Delta distance traveled before/after self-admin	1.3	1.4	2.3	1.1	1.5	-0.8	-1.5	0.8	1.0
Delta ambulatory time before/after self-admin	0.7	0.7	1.3	0.8	1.1	-0.7	-1.1	0.7	0.6
Parametrial fat weight	2.1	4.1	5.4	1.9	2.1	-2.3	-2.2	2.3	0.7
Pavlov. Cond. lever latency	0.6	0.8	1.6	0.9	0.7	-1.3	-0.7	1.2	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	0.1	0.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.7	-0.7	-0.3	0.9	0.3	-0.7	-0.1
Pavlov. Cond. index score	1.2	1.5	2.5	-1.3	-1.1	1.6	1.1	-1.5	-0.4
Pavlov. Cond. latency score	0.8	1.1	1.9	-1.1	-0.9	1.4	0.9	-1.3	-0.1
Pavlov. Cond. lever contacts	0.8	1.0	1.7	-1.1	-0.8	1.3	0.8	-1.2	-0.2
Pavlov. Cond. magazine entry number	0.4	0.4	0.7	0.7	0.7	-0.8	-0.7	0.7	0.0
Pavlov. Cond. intertrial magazine entries	1.3	1.6	2.2	-1.5	-1.5	1.1	1.4	-1.0	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	3.0	-1.4	-1.2	1.7	1.3	-1.6	-0.4
Pavlov. Cond. response bias	1.5	1.8	2.6	-1.5	-1.3	1.6	1.3	-1.4	-0.8
Pavlov. Cond. lever latency	2.4	3.3	4.6	2.1	2.1	-1.7	-2.2	1.6	1.0
Pavlov. Cond. magazine entry latency	1.6	1.9	3.4	-1.9	-1.1	1.3	1.1	-0.8	-1.7
Pavlov. Cond. change in total contacts	3.6	5.0	6.3	-2.5	-2.5	2.0	2.5	-1.9	-1.8
Pavlov. Cond. index score	2.9	3.7	5.5	-2.4	-2.0	1.8	2.0	-1.6	-1.6
Pavlov. Cond. latency score	2.8	3.4	5.4	-2.3	-2.0	1.7	2.0	-1.4	-1.6
Pavlov. Cond. lever contacts	2.2	2.9	4.4	-2.1	-2.0	1.4	2.0	-1.3	-1.1
Pavlov. Cond. magazine entry number	1.6	2.0	2.9	1.7	1.4	-1.4	-1.4	1.2	1.4
Pavlov. Cond. intertrial magazine entries	3.6	4.7	8.2	2.4	1.8	-2.3	-1.8	1.6	2.9
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.4	5.1	-2.2	-1.9	1.8	1.9	-1.5	-1.6
Pavlov. Cond. response bias	2.8	3.8	5.8	-2.4	-2.1	1.8	2.1	-1.6	-1.6
Time in closed arm before self-admin	2.0	2.2	2.7	-1.6	-1.5	1.5	1.4	-1.3	-1.5
Time in closed arm after self-admin	3.7	3.8	4.5	-2.1	-1.9	2.0	2.0	-1.5	-2.1
Time in open arm before self-admin	0.7	0.7	1.7	-1.2	-0.8	0.0	0.7	0.3	-1.3
Time in open arm after self-admin	2.6	2.9	4.9	2.0	1.4	-1.7	-1.5	1.2	2.2
Bone: periosteal estimation	0.3	0.5	0.8	0.9	0.8	-0.6	-0.7	0.7	0.7
Bone: periosteal perimeter	0.2	0.4	0.6	0.7	0.7	-0.5	-0.7	0.5	0.6
Bone: post-yield work	0.3	0.5	1.3	-0.3	-0.4	0.8	0.5	-0.6	-1.1
Progressive ratio test 1 active lever presses	0.3	0.3	0.9	1.0	0.6	-0.3	-0.4	0.1	0.5
Progressive ratio test 1 breakpoint	0.2	0.3	1.0	1.0	0.5	-0.2	-0.3	0.0	0.4
Progressive ratio test 1 inactive lever presses	1.1	1.2	2.0	1.4	0.9	-1.2	-0.9	0.8	1.2
Progressive ratio test 2 active lever presses	3.9	4.2	6.9	2.6	1.9	-2.0	-1.6	1.5	2.5
Progressive ratio test 2 breakpoint	2.9	3.2	5.5	2.3	1.5	-1.7	-1.2	1.2	2.4
Progressive ratio test 2 inactive lever presses	2.2	2.5	5.1	2.0	1.3	-1.5	-1.2	1.0	2.3
Incentive Sensitization - Responses	3.8	3.8	7.8	2.3	1.5	-2.0	-1.4	1.4	2.8
Incentive Sensitization - Breakpoint	3.5	3.6	7.5	2.2	1.4	-2.0	-1.2	1.4	2.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.3	0.1	-0.1	-0.1	-0.2	0.4
Progressive ratio	0.1	0.1	0.4	-0.6	-0.1	0.3	0.2	-0.2	-0.6
Food seeking constrained by brief footshock	0.3	0.4	0.8	0.9	0.8	-0.1	-0.6	-0.2	0.5
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	0.1	0.2	0.0	-0.3	0.1
Retroperitoneal fat weight	0.2	0.8	1.4	0.5	1.1	-0.9	-1.1	1.2	-0.4
Reaction time number correct	0.2	0.3	0.8	0.5	0.3	-0.5	-0.2	0.3	0.9
Reaction time mean minus median	0.1	0.1	0.3	-0.6	0.0	-0.2	0.0	0.4	-0.3
Reaction time mean minus median AUC	0.1	0.1	0.3	0.1	0.3	-0.3	-0.3	0.2	0.5
Reaction time num false alarms	0.2	0.3	0.9	-0.6	-0.9	0.1	0.8	0.1	-0.2
Reaction time num false alarms AUC	0.5	0.6	1.5	-0.8	-1.2	0.5	1.1	-0.4	-0.4
Reaction time trials correct on left	0.2	0.3	0.8	0.5	0.3	-0.5	-0.2	0.3	0.9
Reaction time trials on left	0.2	0.4	1.1	0.7	0.3	-0.6	-0.3	0.3	1.0
Reaction time mean	0.5	0.7	1.5	0.3	0.9	-1.1	-1.0	1.2	0.1
Reaction time mean AUC	0.7	1.0	1.8	0.4	1.1	-1.1	-1.1	1.3	0.2
Median of all reaction times	0.7	1.0	1.8	0.4	1.1	-1.2	-1.1	1.3	0.2
Reaction time omissions	2.5	3.4	5.4	1.9	1.7	-1.8	-1.8	1.3	2.3
Reaction time false alarm rate	0.6	0.9	1.5	-0.9	-1.2	0.8	1.1	-0.7	-0.7
Reaction time premature initiation rate	0.5	0.6	1.4	-1.0	-0.8	0.3	0.8	-0.0	-1.2
Reaction time premature initiations	0.1	0.2	0.3	-0.5	-0.4	-0.1	0.5	0.2	-0.5
Std. dev. reaction times	0.4	0.6	0.8	0.4	0.9	-0.9	-0.9	0.9	0.4
Reaction time trials completed	0.2	0.4	1.1	0.7	0.3	-0.6	-0.3	0.3	1.0
Reaction time trials AUC	0.2	0.4	0.9	0.6	0.3	-0.6	-0.3	0.4	1.0
Run reversals in cocaine runway, females	1.3	1.2	2.1	0.6	1.1	-1.3	-1.4	1.5	0.4
Run reversals in cocaine runway, males	0.9	0.9	1.2	-1.0	-1.0	1.0	1.1	-0.7	-0.8
Latency to leave start box in cocaine runway	0.8	0.9	1.3	1.0	1.1	-0.8	-1.0	0.7	1.0
Latency to leave start box in cocaine runway, F	1.6	1.8	2.5	1.5	1.5	-1.2	-1.1	1.0	1.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.1	-0.2	0.2	-0.1	-0.5	0.5
Std. dev. time between licks in bursts	2.3	2.7	4.3	1.3	1.6	-2.0	-1.6	2.1	1.1
Total sessions with >9 infusions	5.0	5.5	7.0	2.6	2.6	-2.1	-2.4	2.0	2.1
Short access day 1 total inactive lever presses	0.2	0.2	0.3	0.6	0.4	-0.5	-0.3	0.3	0.4
Short access day 10 total inactive lever presses	0.3	0.3	1.3	0.7	-0.1	-0.1	0.1	-0.4	1.1
Short access day 1 total infusions	4.1	4.4	5.8	2.3	2.4	-2.0	-2.2	2.0	1.4
Short access day 10 total infusions	0.2	0.2	0.4	0.2	0.6	-0.2	-0.4	0.5	-0.6
Short access total infusions	1.5	1.7	2.8	1.4	1.7	-1.2	-1.4	1.4	0.4
Short access day 1 locomotion	1.4	1.5	2.5	1.4	1.6	-0.9	-1.5	1.0	0.8
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	0.2	0.2	-0.1	-0.1	-0.1
Short access total locomotion	0.3	0.3	0.7	0.5	0.8	-0.2	-0.7	0.3	0.3
One hour access (0.3 mA shock)	2.1	2.5	3.5	1.9	1.8	-1.3	-1.6	1.1	1.6
Compulsive drug intake	0.4	0.5	1.1	-0.7	-0.4	0.9	0.3	-1.0	-0.2
One hour access (shock baseline)	3.5	4.0	5.0	2.2	2.1	-2.2	-1.9	2.1	1.4
Social response proportion	3.2	3.5	4.2	1.8	2.0	-2.0	-2.0	1.8	1.5
Social responses	1.7	2.2	2.7	1.4	1.5	-1.6	-1.4	1.5	1.5
Social time	0.3	0.4	0.6	-0.4	-0.8	0.2	0.8	-0.5	0.7
Soleus weight	0.7	2.0	3.6	-0.8	-1.4	1.8	1.3	-1.9	-0.9
Bone: stiffness	0.3	0.5	0.8	-0.3	-0.9	0.8	0.9	-0.6	-0.4
Tibialis anterior weight	7.8	26.6	30.8	-5.0	-5.5	5.6	5.4	-5.2	-4.2
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.5	-0.7	-0.2	-0.3	0.4	0.7	-0.6
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.7	-0.6	-0.5	0.3	0.5	-0.2	-0.8
Time to tail flick, test, before self-admin	0.8	0.8	1.7	-1.0	-1.3	0.4	1.3	-0.3	-0.5
Time to tail flick, test, after self-admin	2.1	2.2	2.9	1.2	1.6	-1.7	-1.5	1.6	1.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.5	0.1	0.1	-0.2	-0.4	0.4
Delta time to tail flick, test, before/after SA	2.6	2.3	3.5	1.4	1.9	-1.4	-1.9	1.4	1.0
Tibia length	0.4	1.1	2.2	-1.0	-1.5	0.6	1.5	-0.7	0.6
Ambulatory time before self-admin	0.7	0.7	1.3	-1.1	-0.8	0.6	0.7	-0.3	-1.2
Ambulatory time after self-admin	0.5	0.5	2.2	-0.9	-0.1	0.4	0.0	0.1	-1.5
Bone: tissue strength	0.4	0.4	0.9	0.5	0.2	-1.0	-0.2	0.9	0.6
Total heroin consumption	0.2	0.2	0.7	-0.3	-0.3	0.7	0.3	-0.8	0.1
Bone: trabecular number	0.6	1.0	1.8	0.5	0.9	-1.3	-0.9	1.3	0.6
Bone: trabecular spacing	0.5	0.7	1.2	-0.5	-0.5	1.1	0.4	-0.9	-1.1
Bone: trabecular thickness	0.8	1.0	1.5	-0.9	-1.2	1.0	1.2	-0.9	-0.5
Bone: trabecular tissue density	1.0	1.4	2.6	-0.6	-1.1	1.5	1.1	-1.6	-0.6
Water consumed over 24 hours	0.4	0.5	1.0	-0.8	-1.0	0.5	1.0	-0.3	-0.5
Number of responses in last shaping day	0.5	0.5	1.3	0.4	0.5	-0.8	-0.6	1.1	-0.5