Hub : Genes

N4bp2l1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression N4bp2l1 0.11 0.06 6.2e-07 0.05 0.07 0.06 0.06 1.2e-05 8.7e-07 2.1e-06 1.8e-06
2 Brain alternative TSS NM_001035222.2 0.08 0.05 5.4e-05 0.04 0.04 0.04 0.04 2.8e-04 2.0e-04 2.3e-04 2.8e-04
3 Brain alternative TSS XM_039089675.1 0.08 0.05 8.1e-05 0.04 0.04 0.04 0.04 2.5e-04 2.1e-04 2.2e-04 2.2e-04
4 PL alternative TSS XM_039089675.1 0.05 0.03 2.8e-04 0.04 0.04 0.03 0.04 1.4e-05 6.3e-05 5.0e-04 2.2e-05
5 PL alternative TSS NM_001035222.2 0.05 0.03 2.7e-04 0.04 0.04 0.03 0.04 1.4e-05 7.6e-05 3.3e-04 3.5e-05
6 Adipose gene expression N4bp2l1 0.36 0.12 0.0e+00 0.28 0.28 0.28 0.28 1.2e-30 2.3e-31 1.1e-31 1.4e-31
7 PL gene expression N4bp2l1 0.05 0.03 1.2e-04 0.04 0.03 0.03 0.03 3.5e-05 3.7e-04 4.0e-04 1.8e-04
8 Liver gene expression N4bp2l1 0.2 0.09 0.0e+00 0.13 0.16 0.16 0.16 1.1e-14 4.9e-17 4.6e-17 7.8e-17
9 BLA gene expression N4bp2l1 0.1 0.06 7.3e-04 0.06 0.06 0.06 0.06 3.2e-04 3.2e-04 3.5e-04 5.7e-04
10 Adipose mRNA stability N4bp2l1 0.05 0.03 6.1e-05 0.01 0.03 0.02 0.03 8.2e-03 1.6e-04 3.9e-03 7.8e-04
11 pVTA gene expression N4bp2l1 0.2 0.1 3.2e-05 0.05 0.11 0.04 0.08 3.5e-03 2.6e-05 5.3e-03 1.9e-04
12 Liver isoform ratio XR_005491656.1 0.04 0.03 6.7e-04 0.03 0.02 0.02 0.03 3.2e-04 1.0e-03 2.1e-03 6.8e-04
13 PL isoform ratio NM_001035222.2 0.03 0.02 3.2e-03 0.01 0 0 0 1.5e-02 2.3e-01 2.0e-01 7.6e-02
14 IL isoform ratio NM_001035222.2 0.16 0.1 8.5e-03 0.04 0.12 0.12 0.11 4.0e-02 8.9e-04 6.9e-04 1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density4.77.811.6-3.4-3.43.4-3.03.02.92.92.6-2.71.8-3.3-2.11.1-2.5
Area under the delay curve1.11.23.01.31.7-1.70.9-0.9-0.7-0.8-0.40.40.31.60.61.01.5
BMI with tail1.75.610.3-2.4-1.41.3-2.92.82.52.72.1-3.22.5-2.1-1.63.0-1.4
BMI without tail2.65.49.3-2.3-1.91.9-2.72.72.62.52.4-2.53.0-1.4-1.83.1-0.1
Body weight15.063.184.4-8.7-7.37.1-9.29.28.88.98.2-8.88.0-7.1-6.57.8-4.0
Weight adjusted by age0.91.02.0-1.2-1.41.4-1.00.80.91.10.9-0.70.3-1.3-1.0-0.2-1.1
Bone surface5.910.414.0-3.7-3.33.3-3.73.63.43.53.1-3.52.6-3.5-2.82.2-2.5
Bone volume3.76.39.5-3.0-2.72.6-2.82.82.62.72.2-2.71.6-3.1-1.81.2-2.6
Breakpoint value in progressive ratio session0.30.41.70.30.5-0.5-0.20.20.20.20.2-0.20.90.7-0.01.31.1
Number of licking bursts1.01.22.6-1.3-1.61.6-1.11.21.11.01.0-0.70.6-1.2-1.1-0.0-0.8
Context. condit. distance diff. score2.73.26.3-1.6-1.51.5-1.92.02.11.92.2-1.52.5-0.6-1.82.30.5
Locomotion velocity, session 10.91.02.01.11.1-1.11.0-0.9-1.0-1.0-0.80.9-0.31.21.4-0.11.1
Locomotion distance, session 12.22.84.41.81.6-1.51.8-1.7-1.8-2.0-1.71.8-1.21.72.1-1.01.3
Locomotion velocity, session 20.30.41.00.80.6-0.60.5-0.6-0.5-0.5-0.30.7-0.11.00.50.11.0
Locomotion distance, session 22.23.05.61.91.2-1.11.9-1.9-1.7-1.9-1.42.4-1.12.11.7-1.32.0
Locomotion velocity, session 30.10.10.4-0.1-0.10.1-0.20.30.20.20.2-0.20.60.1-0.10.70.4
Locomotion distance, session 30.10.10.60.2-0.20.20.4-0.4-0.3-0.3-0.10.6-0.50.2-0.2-0.80.1
Stereotopy head waving bouts, day 33.33.95.2-2.3-2.32.3-2.32.22.12.12.1-1.91.6-2.0-1.81.2-1.2
Stereotopy head waving duration, day 30.20.30.6-0.6-0.40.4-0.60.50.50.50.4-0.70.1-0.8-0.40.2-0.8
Locomotion velocity, session 71.01.12.41.11.5-1.50.7-0.7-0.8-0.8-0.70.40.11.31.50.81.3
Locomotion distance, session 70.70.93.41.10.9-0.90.8-0.7-0.7-0.9-0.41.00.31.60.60.51.8
Stereotopy head waving bouts, day 70.70.81.41.10.8-0.81.0-1.2-0.8-0.9-0.31.1-0.71.1-0.4-0.70.9
Stereotopy head waving duration, day 70.50.61.21.00.9-0.80.9-1.1-0.8-0.9-0.40.9-0.80.9-0.3-0.70.5
Locomotion velocity, session 80.10.20.9-0.10.2-0.2-0.30.30.20.3-0.0-0.40.70.20.31.00.5
Locomotion distance, session 80.50.82.2-0.7-0.60.7-0.91.01.00.90.9-0.71.5-0.1-0.11.50.6
Degree of sensitization distance1.21.22.41.31.4-1.31.1-1.1-1.0-1.2-0.81.0-0.21.60.80.11.5
Degree of sensitization stereotypy0.50.50.90.90.9-0.80.8-1.0-0.6-0.7-0.20.8-0.50.9-0.4-0.40.7
Conditioned locomotion0.10.10.6-0.4-0.40.4-0.20.20.20.20.0-0.2-0.3-0.6-0.4-0.4-0.8
Cocaine response after cond. corrected1.11.25.4-1.0-0.10.0-1.10.90.71.10.2-1.8-0.2-1.80.70.3-2.3
Cocaine response after cond. not corrected0.60.72.3-0.70.2-0.3-0.80.80.61.00.2-1.50.1-1.20.60.7-1.5
Cocaine response before conditioning0.60.73.80.70.4-0.30.5-0.3-0.2-0.40.20.80.71.4-0.80.71.9
Saline control response2.33.09.0-1.5-2.32.4-1.41.41.81.52.3-0.51.8-0.6-3.00.80.5
Bone: connectivity density6.410.113.9-3.7-3.73.7-3.53.63.43.43.0-3.02.8-3.2-2.92.1-1.9
Bone: cortical apparent density0.50.61.51.01.2-1.20.7-0.7-0.8-0.8-0.70.4-0.30.90.50.20.7
Bone: cortical area1.82.85.5-1.6-1.11.1-2.01.91.81.91.7-1.92.2-1.0-0.92.4-0.2
Bone: cortical porosity0.20.21.4-0.4-0.40.4-0.30.20.40.40.5-0.20.1-0.4-1.2-0.1-0.3
Bone: cortical porosity0.20.20.80.50.2-0.20.5-0.5-0.3-0.30.00.6-0.20.6-0.9-0.40.6
Bone: cortical thickness1.62.65.0-1.6-1.11.1-2.01.91.81.91.5-1.92.1-1.1-1.02.2-0.3
Bone: cortical thickness1.01.22.2-0.9-1.11.1-1.11.01.21.11.4-0.71.5-0.3-1.31.20.4
Bone: cortical tissue density0.50.71.51.01.2-1.20.8-0.8-0.9-0.9-0.80.5-0.40.90.5-0.00.6
Condit. Reinf. active minus inactive responses0.50.61.40.91.2-1.20.9-0.9-0.6-0.4-0.60.4-0.60.81.1-0.20.4
Condit. Reinf. active-inactive response ratio0.20.20.90.50.9-1.00.3-0.4-0.2-0.0-0.3-0.1-0.10.40.50.40.2
Condit. Reinf. active responses0.60.81.51.11.0-0.91.0-1.0-0.7-0.7-0.51.0-0.41.20.9-0.31.1
Condit. Reinf. inactive responses1.41.73.31.50.9-0.81.5-1.4-1.2-1.4-0.91.8-0.61.81.0-0.81.8
Incentive salience index mean0.70.91.31.11.1-1.11.1-1.1-0.8-0.8-0.71.0-0.61.10.9-0.50.9
Condit. Reinf. lever presses0.60.81.61.10.8-0.71.0-1.0-0.9-1.0-0.61.2-0.41.30.6-0.51.2
Condit. Reinf. active minus inactive responses1.11.33.8-0.5-0.50.6-0.90.91.10.91.6-0.51.90.5-1.31.91.3
Condit. Reinf. active-inactive response ratio0.60.62.30.10.1-0.0-0.30.40.50.30.8-0.11.40.9-0.81.51.5
Condit. Reinf. active responses1.11.64.5-0.5-0.60.6-1.00.91.21.01.8-0.52.10.6-1.22.11.5
Condit. Reinf. inactive responses0.30.30.8-0.5-0.60.6-0.60.50.70.60.9-0.30.8-0.0-0.30.60.4
Condit. Reinf. lever presses0.10.10.4-0.0-0.10.2-0.20.20.30.20.60.00.70.4-0.20.60.7
Condit. Reinf. lever reinforcers received0.81.13.3-0.1-0.20.3-0.60.50.80.61.4-0.11.80.9-1.01.81.8
Conditioned reinforcement - actives4.44.48.0-2.0-2.42.4-2.02.02.42.12.7-1.42.5-1.0-2.81.90.2
Conditioned reinforcement - inactives0.40.51.3-0.8-1.11.2-0.50.50.60.50.7-0.20.3-0.7-1.1-0.2-0.4
Conditioned locomotion2.93.45.7-1.8-2.02.1-1.81.82.11.92.4-1.32.2-0.9-2.31.80.2
Patch foraging indifference point 0 sec0.40.61.8-0.7-1.21.2-0.20.10.20.20.30.1-0.8-1.1-0.6-1.3-1.3
Patch foraging indifference point AUC0.60.71.6-0.8-1.21.2-0.80.80.90.71.0-0.30.8-0.4-1.30.30.1
Delay disc. indifference point, 0s delay1.11.24.6-0.60.8-0.9-0.80.80.61.00.3-2.11.1-0.70.82.1-0.8
Delay disc. indifference point, 16s delay0.70.71.81.11.1-1.10.9-0.9-0.5-0.7-0.10.70.01.3-0.10.31.3
Delay disc. indifference point, 2s delay1.92.16.41.62.5-2.51.2-1.3-1.2-1.2-1.10.3-0.21.61.50.91.2
Delay disc. indifference point, 24s delay0.70.71.31.01.1-1.10.9-0.9-0.6-0.7-0.50.6-0.31.10.50.10.9
Delay disc. indifference point, 4s delay0.80.82.70.91.6-1.60.7-0.7-0.7-0.6-0.7-0.0-0.00.91.00.80.6
Delay disc. indifference point, 8s delay0.80.92.51.21.1-1.00.9-0.9-0.6-0.9-0.30.90.11.50.10.31.6
Indifference point function ln k0.10.20.80.3-0.20.30.5-0.5-0.2-0.4-0.00.9-0.30.5-0.1-0.60.6
Indifference point function log k0.10.20.80.3-0.20.30.5-0.5-0.2-0.4-0.00.9-0.30.5-0.1-0.60.6
Patch foraging total patch changes 0 sec0.40.72.7-0.6-1.21.2-0.0-0.10.10.00.20.4-0.9-1.0-0.6-1.6-1.3
Patch foraging total patch changes 12 sec0.50.61.3-0.9-1.11.1-0.60.50.50.50.6-0.4-0.1-1.1-0.8-0.6-1.1
Patch foraging total patch changes 18 sec0.60.82.0-0.9-1.31.3-0.40.40.30.30.2-0.1-0.6-1.2-0.5-1.4-1.4
Patch foraging total patch changes 24 sec0.40.51.9-0.0-1.01.00.3-0.4-0.1-0.40.21.1-0.50.2-1.3-1.40.2
Patch foraging total patch changes 6 sec0.60.92.3-1.0-1.51.5-0.60.50.70.60.7-0.1-0.3-1.2-0.8-1.1-1.2
Patch foraging time to switch 0 sec1.11.85.90.42.0-2.20.2-0.2-0.8-0.2-1.5-1.3-1.0-0.72.40.4-1.8
Patch foraging water rate 0 sec1.82.99.7-1.6-3.03.1-1.11.11.61.22.00.21.1-0.8-2.4-0.40.2
Patch foraging water rate 12 sec0.30.51.50.1-0.81.00.2-0.20.1-0.10.61.00.20.6-1.2-0.51.0
Patch foraging water rate 18 sec0.71.04.11.10.4-0.30.9-1.0-0.5-0.80.11.50.11.7-0.4-0.12.0
Patch foraging water rate 24 sec1.41.94.2-1.2-2.02.0-1.11.21.51.11.8-0.31.5-0.4-2.00.70.6
Patch foraging water rate 6 sec0.20.31.1-0.4-1.01.1-0.30.30.40.30.50.40.50.1-0.7-0.10.6
Seeking ratio, delayed vs. immediate footshock2.02.35.01.11.0-1.01.5-1.5-1.7-1.5-2.01.2-2.20.21.8-2.2-0.7
Distance traveled before self-admin0.50.61.30.91.0-1.00.5-0.6-0.5-0.5-0.40.50.11.10.90.41.1
Distance traveled after self-admin0.20.21.00.50.2-0.20.3-0.4-0.2-0.20.00.60.20.9-0.20.11.0
Extensor digitorum longus weight4.919.426.2-4.6-4.44.4-4.94.85.04.85.1-4.14.9-3.1-4.34.4-0.9
Bone: elastic displacement0.40.50.9-0.9-0.90.9-0.80.80.70.80.5-0.60.6-0.8-0.50.4-0.5
Bone: elastic work4.25.47.0-2.6-2.62.6-2.52.52.52.62.5-2.12.1-2.1-2.51.6-1.1
Bone: endosteal estimation0.92.14.4-1.7-2.12.1-1.51.41.51.41.6-0.90.9-1.5-1.20.2-1.0
Bone: endosteal perimeter0.71.52.7-1.2-1.51.6-1.21.11.41.11.6-0.71.3-0.6-1.50.80.1
Epididymis fat weight0.10.31.4-0.3-0.10.1-0.40.40.60.60.8-0.60.7-0.1-1.20.80.1
Delta time in closed arm before/after self-admin0.20.20.80.10.1-0.0-0.10.10.20.00.20.10.60.50.40.60.9
Delta time in open arm before/after self-admin3.43.34.21.91.8-1.82.0-2.0-2.0-1.9-2.11.7-2.01.41.5-1.80.5
Diff in mean of infusions in LGA sessions0.20.20.90.30.00.00.3-0.2-0.2-0.20.10.60.20.7-0.40.01.0
Delay discount exponential model param1.51.63.6-1.5-1.91.8-1.11.20.91.00.5-0.8-0.2-1.9-0.6-0.9-1.8
Extinction: sum of active levers before priming1.61.62.41.51.4-1.41.4-1.4-1.3-1.4-1.11.3-0.81.51.0-0.71.3
Active lever presses in extinction session 60.00.00.1-0.2-0.20.2-0.20.20.10.10.0-0.10.2-0.10.10.20.2
Bone: final force2.84.66.3-2.2-1.91.9-2.52.32.42.42.5-2.12.4-1.5-2.12.3-0.6
Bone: final moment2.43.95.3-2.1-1.81.8-2.32.22.22.22.2-2.02.2-1.5-1.82.0-0.7
Food consumed during 24 hour testing period0.40.51.1-0.8-1.01.0-0.60.60.60.60.4-0.4-0.1-1.0-0.1-0.4-0.9
Glucose0.30.51.50.81.2-1.20.6-0.6-0.7-0.6-0.90.2-0.40.60.60.10.2
Heart weight0.50.84.40.5-0.40.50.3-0.30.1-0.30.61.30.71.4-1.00.12.1
Delay discount hyperbolic model param1.51.53.7-1.5-1.91.9-1.11.20.91.00.6-0.6-0.1-1.8-0.7-0.8-1.6
Intermittent access intake day 1-15 change1.21.23.2-1.3-1.81.8-1.11.01.10.91.1-0.60.7-1.1-1.00.1-0.7
Intermittent access intake escalation1.00.92.7-1.1-1.61.7-0.90.91.00.81.1-0.30.8-0.7-1.00.2-0.1
Intermittent access intake escalation 20.10.10.4-0.0-0.50.60.2-0.2-0.1-0.30.00.6-0.20.10.0-0.60.2
Intermitt. access day 1 inactive lever presses0.60.61.8-0.9-1.31.3-0.50.60.70.60.7-0.30.2-0.9-1.0-0.3-0.7
Intermitt. access day 15 inactive lever presses0.80.84.8-0.8-0.20.1-0.60.60.20.6-0.3-1.2-0.7-1.70.5-0.3-2.2
Intermitt. access escalation Index0.80.71.40.90.5-0.50.9-0.9-0.9-1.0-0.61.2-0.31.20.3-0.51.2
Intermittent access day 1 total infusions1.11.22.71.41.2-1.21.1-1.2-1.0-1.0-0.71.2-0.41.60.5-0.31.5
Intermittent access day 15 total infusions0.20.20.70.2-0.30.40.2-0.3-0.0-0.20.30.70.10.6-0.4-0.30.8
Intermittent access terminal intake (last 3 days)0.30.30.70.60.3-0.30.6-0.8-0.5-0.6-0.40.9-0.40.70.3-0.70.6
Intermittent access total infusions0.60.61.21.00.9-0.90.7-0.9-0.7-0.7-0.50.8-0.31.10.6-0.21.0
Intermittent access day 1 locomotion2.02.13.41.81.8-1.81.5-1.6-1.4-1.4-1.21.4-0.81.81.3-0.41.5
Intermittent access day 15 total locomotion0.30.32.20.40.00.10.1-0.20.0-0.20.30.60.71.0-0.10.51.5
Intermittent access total locomotion1.31.43.41.51.3-1.31.1-1.2-1.0-1.1-0.71.2-0.21.80.90.01.8
Intermittent access standard deviation0.91.03.4-1.2-1.11.1-0.80.80.70.90.4-0.9-0.2-1.7-0.2-0.4-1.8
Left kidney weight11.432.242.9-6.0-5.95.9-6.16.16.36.16.5-5.25.8-4.4-6.44.9-1.9
Right kidney weight8.624.230.6-5.4-5.15.1-5.55.55.55.35.3-4.84.9-4.2-4.64.3-2.0
Cocaine induced anxiety0.50.61.11.01.0-0.90.9-0.8-0.8-0.9-0.60.7-0.31.00.5-0.10.9
Post-drug Anxiety3.74.28.12.42.8-2.92.1-2.0-2.1-2.0-2.01.5-1.32.12.1-0.41.4
Baseline Anxiety2.62.86.61.82.5-2.51.4-1.4-1.7-1.3-2.10.7-1.51.12.6-0.40.2
Tail length7.221.930.8-4.8-4.54.5-5.35.45.35.15.2-4.55.6-3.2-3.95.2-0.7
Length with tail16.861.680.6-8.5-7.77.6-8.99.08.98.78.5-7.98.3-6.4-6.87.7-2.9
Length without tail11.424.932.6-5.5-4.54.4-5.65.75.65.75.2-5.64.8-4.6-4.34.7-2.9
Times rat made contact with spout0.60.71.5-0.8-0.80.9-1.01.01.01.00.9-0.71.2-0.4-0.41.10.2
Lifetime Intake0.50.51.00.91.0-1.00.6-0.8-0.7-0.6-0.70.5-0.50.70.9-0.30.4
Liver weight, left1.72.74.9-2.0-2.22.1-1.51.51.41.41.4-1.30.3-2.2-2.0-0.3-2.0
Liver weight, right4.16.89.0-3.0-3.03.0-2.82.92.92.82.9-2.42.4-2.4-2.41.8-1.3
Locomotor activity1.93.16.6-1.0-1.61.8-1.31.21.81.42.6-0.32.60.5-2.52.01.9
Locomotor testing distance0.71.22.9-0.9-1.51.6-0.90.81.20.91.6-0.21.1-0.3-1.70.50.4
Locomotor testing rearing0.10.21.10.1-0.30.40.3-0.5-0.2-0.3-0.10.6-0.6-0.00.0-1.0-0.2
Locomotion in novel chamber0.40.50.9-0.6-0.91.0-0.60.80.80.50.9-0.20.8-0.2-0.90.50.2
Locomotion in novel chamber post-restriction2.12.55.0-1.2-1.81.9-1.41.41.81.52.0-0.52.1-0.2-2.21.51.0
Fecal boli incidents, locomotor time 10.91.01.7-0.8-1.11.1-1.11.01.21.01.3-0.41.3-0.2-1.21.00.6
Change in fecal boli incidents, locomotor task0.40.31.00.10.5-0.60.4-0.4-0.5-0.3-0.8-0.2-0.8-0.50.7-0.6-1.0
Time >=10cm from walls, locomotor time 11.91.94.31.52.0-2.11.4-1.4-1.6-1.4-1.60.6-1.01.11.7-0.30.5
Bouts of movement, locomotor time 11.61.73.2-1.2-1.41.4-1.31.31.61.51.7-0.91.4-0.7-1.81.10.0
Total resting periods, locomotor time 11.31.53.0-1.0-1.21.3-1.21.21.51.41.6-0.71.4-0.5-1.71.10.2
Rest time, locomotor task time 10.70.81.3-0.9-0.80.7-1.01.01.01.10.9-0.90.9-0.7-1.10.8-0.3
Distance moved, locomotor task time 10.60.71.31.00.7-0.70.8-0.8-0.8-0.9-0.51.0-0.31.10.8-0.31.0
Vertical activity count, locomotor time 10.30.31.70.3-0.20.30.1-0.10.0-0.20.30.80.40.9-0.40.21.3
Time >=10cm from walls, locomotor time 20.70.82.6-0.70.1-0.2-0.90.90.70.90.4-1.61.0-0.80.11.6-0.6
Bouts of movement, locomotor time 21.61.83.3-1.3-1.51.5-1.41.31.71.61.8-0.91.4-0.7-1.51.0-0.0
Total resting periods, locomotor time 21.71.83.0-1.3-1.51.5-1.41.31.71.71.7-1.01.3-0.9-1.40.9-0.3
Rest time, locomotor task time 20.20.20.30.50.5-0.50.5-0.5-0.4-0.4-0.50.3-0.50.30.3-0.40.1
Distance moved, locomotor task time 20.10.10.3-0.3-0.50.5-0.30.30.30.20.2-0.00.2-0.2-0.10.0-0.0
Vertical activity count, locomotor time 21.92.14.0-1.5-2.02.0-1.61.61.61.51.7-0.71.4-0.9-1.60.9-0.0
Light reinforcement 11.12.04.11.81.8-1.81.3-1.3-1.3-1.4-1.11.3-0.42.00.9-0.01.8
Light reinforcement 20.10.10.30.30.2-0.20.4-0.4-0.4-0.3-0.40.4-0.50.20.2-0.6-0.0
Bone: marrow area0.92.04.6-1.7-2.12.1-1.41.41.51.41.6-0.90.9-1.5-1.20.1-1.0
Bone: maximum diameter1.73.14.2-2.0-1.81.8-2.02.02.02.01.9-1.91.7-1.7-1.11.4-1.0
Bone: maximum force2.34.15.6-2.1-2.12.1-2.32.22.22.22.4-1.82.2-1.5-2.01.8-0.6
Bone: maximum moment2.03.44.4-2.0-2.02.0-2.12.02.02.02.1-1.71.9-1.5-1.71.5-0.7
Mean time between licks in bursts1.62.23.11.61.3-1.31.8-1.8-1.7-1.7-1.61.6-1.71.20.6-1.70.5
Mean num. licks in bursts0.10.10.30.40.6-0.60.2-0.3-0.2-0.2-0.10.10.10.50.30.40.4
Cd content in liver3.03.37.01.80.9-0.82.1-2.1-1.9-2.2-1.72.6-1.71.81.4-2.11.5
Co content in liver0.50.62.0-0.9-1.41.4-0.50.50.50.40.3-0.0-0.1-1.0-0.4-0.7-0.8
Cu content in liver0.10.20.60.2-0.20.20.4-0.4-0.4-0.6-0.40.6-0.50.10.0-0.80.0
Fe content in liver1.41.74.2-1.0-1.31.4-1.21.21.41.11.6-0.61.7-0.2-2.11.40.7
K content in liver0.10.11.0-0.2-0.10.1-0.20.30.20.20.1-0.30.2-0.2-1.00.3-0.1
Mg content in liver0.50.51.0-0.8-0.70.7-0.90.90.70.70.6-0.80.7-0.6-1.00.7-0.3
Mn content in liver0.30.41.10.40.4-0.50.6-0.6-0.7-0.5-0.90.4-1.0-0.0-0.0-0.9-0.5
Na content in liver0.30.31.3-0.3-0.0-0.0-0.50.50.40.40.3-0.60.7-0.1-1.10.80.1
Rb content in liver2.02.43.51.71.6-1.61.7-1.7-1.9-1.9-1.81.5-1.71.21.3-1.40.5
Se content in liver0.60.73.3-0.40.2-0.2-0.90.90.70.90.4-1.11.3-0.10.71.80.4
Sr content in liver0.90.82.3-1.0-1.21.2-0.60.60.50.60.3-0.6-0.3-1.4-0.8-0.6-1.5
Zn content in liver4.04.46.8-2.5-2.62.6-2.22.22.12.11.9-1.91.3-2.5-1.90.8-1.9
Bone: minimum diameter0.00.00.0-0.1-0.20.2-0.1-0.0-0.0-0.00.00.1-0.1-0.1-0.1-0.2-0.1
Time in familiar zone, hab. session 10.50.42.4-0.2-0.10.00.1-0.1-0.3-0.2-0.6-0.3-1.0-1.00.1-1.0-1.5
Time in novel zone, hab. session 10.40.41.0-0.3-0.20.3-0.50.50.70.70.8-0.41.00.1-0.41.00.6
Total zone transitions, hab. session 12.23.15.52.11.8-1.71.9-2.0-1.7-1.8-1.52.0-0.92.31.4-0.72.1
Total locomotion distance, hab. session 10.71.01.81.31.3-1.31.0-1.2-0.9-0.9-0.70.9-0.41.40.7-0.11.2
Locomotion velocity, hab. session 11.82.54.12.01.9-1.81.7-1.8-1.5-1.6-1.31.6-0.82.01.3-0.51.7
Time in familiar zone, hab. session 20.30.31.2-0.40.1-0.2-0.40.40.10.3-0.3-0.8-0.2-0.81.10.1-1.1
Time in novel zone, hab. session 20.70.71.81.00.6-0.50.9-1.0-0.6-0.8-0.21.2-0.21.3-0.5-0.41.4
Total zone transitions, hab. session 20.10.10.60.0-0.20.2-0.10.10.10.10.20.20.50.4-0.00.40.8
Total locomotion distance, hab. session 20.20.30.90.70.5-0.40.6-0.7-0.4-0.5-0.20.8-0.10.90.1-0.11.0
Locomotion velocity, hab. session 20.20.30.90.70.4-0.40.6-0.7-0.4-0.5-0.20.8-0.10.90.1-0.21.0
Novel to familiar place preference ratio0.10.10.40.30.2-0.10.1-0.3-0.0-0.10.10.30.10.5-0.60.00.6
Novelty place preference0.20.20.60.60.5-0.40.5-0.6-0.4-0.4-0.20.6-0.20.8-0.4-0.20.7
Time in novel zone, NPP test0.10.10.40.40.3-0.30.2-0.4-0.2-0.20.00.40.00.6-0.6-0.00.6
Total zone transitions, NPP test0.10.21.00.30.2-0.20.2-0.2-0.1-0.20.10.40.40.70.30.41.0
Total locomotion distance, NPP test0.40.62.10.80.9-0.80.5-0.6-0.3-0.40.00.60.41.30.40.61.4
Locomotion velocity, NPP test0.50.73.30.90.6-0.60.6-0.6-0.2-0.40.20.80.51.50.20.61.8
Intraocular pressure1.72.48.6-1.4-1.71.7-1.31.31.61.42.0-0.91.5-0.9-2.91.0-0.1
Delta distance traveled before/after self-admin0.20.21.2-0.1-0.60.60.2-0.10.0-0.10.20.5-0.10.0-1.1-0.60.1
Delta ambulatory time before/after self-admin0.30.31.10.40.00.00.7-0.6-0.5-0.6-0.30.8-0.60.3-0.3-1.00.2
Parametrial fat weight0.40.72.4-1.0-0.60.5-0.70.80.60.60.5-1.10.0-1.4-0.60.1-1.5
Pavlov. Cond. lever latency3.24.05.4-2.3-2.32.3-2.22.22.22.12.0-1.91.6-2.1-2.01.2-1.4
Pavlov. Cond. magazine entry latency0.10.20.6-0.1-0.10.1-0.40.30.30.20.2-0.10.70.3-0.40.70.6
Pavlov. Cond. change in total contacts0.60.72.00.91.4-1.40.5-0.6-0.6-0.5-0.70.2-0.10.91.10.60.7
Pavlov. Cond. index score0.20.30.60.70.8-0.80.4-0.5-0.5-0.5-0.50.4-0.00.80.40.30.8
Pavlov. Cond. latency score0.60.81.41.11.2-1.20.8-0.8-0.8-0.8-0.80.7-0.21.10.90.11.0
Pavlov. Cond. lever contacts2.22.53.71.81.9-1.91.7-1.7-1.7-1.6-1.61.4-1.31.61.7-0.81.0
Pavlov. Cond. magazine entry number0.30.41.00.20.3-0.30.4-0.4-0.5-0.3-0.60.1-1.0-0.41.0-1.0-1.0
Pavlov. Cond. intertrial magazine entries1.21.42.41.20.8-0.81.3-1.3-1.2-1.2-1.21.4-1.30.91.6-1.40.4
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.50.7-0.70.3-0.3-0.4-0.3-0.40.2-0.00.50.40.30.5
Pavlov. Cond. response bias0.10.10.60.20.2-0.2-0.0-0.00.0-0.00.20.10.40.5-0.50.50.8
Pavlov. Cond. lever latency0.81.04.0-1.1-1.11.0-0.70.70.60.80.3-0.9-0.5-1.7-0.6-0.7-2.0
Pavlov. Cond. magazine entry latency1.92.24.61.82.1-2.11.4-1.5-1.4-1.4-1.11.1-0.42.00.70.31.7
Pavlov. Cond. change in total contacts0.70.93.61.10.8-0.70.8-0.8-0.6-0.9-0.21.10.31.70.20.31.9
Pavlov. Cond. index score1.62.15.21.81.6-1.61.4-1.4-1.2-1.4-0.81.4-0.12.20.70.32.3
Pavlov. Cond. latency score1.51.84.21.71.6-1.61.3-1.3-1.2-1.3-0.81.3-0.12.00.70.32.0
Pavlov. Cond. lever contacts0.71.02.91.11.1-1.10.7-0.8-0.7-0.8-0.40.80.31.60.90.61.7
Pavlov. Cond. magazine entry number2.22.75.1-2.0-2.02.0-1.71.71.61.81.2-1.60.6-2.3-0.50.2-2.0
Pavlov. Cond. intertrial magazine entries0.40.51.2-0.8-1.11.1-0.70.70.80.70.8-0.30.7-0.5-0.40.3-0.0
Pavlov. Cond. lever-magazine prob. diff.1.82.35.71.81.7-1.61.5-1.5-1.3-1.5-0.81.5-0.12.30.60.22.4
Pavlov. Cond. response bias1.72.36.11.81.7-1.61.3-1.4-1.2-1.4-0.81.40.12.41.10.42.5
Time in closed arm before self-admin1.92.16.0-1.5-2.02.0-1.21.21.41.31.8-0.71.1-1.1-2.50.4-0.5
Time in closed arm after self-admin1.01.03.3-0.7-1.41.4-0.70.71.00.61.40.01.20.1-1.80.60.9
Time in open arm before self-admin0.10.10.6-0.10.1-0.0-0.30.30.30.30.1-0.30.60.20.10.80.4
Time in open arm after self-admin0.20.30.60.40.7-0.70.4-0.5-0.5-0.3-0.70.1-0.70.10.6-0.4-0.3
Bone: periosteal estimation1.73.54.7-2.1-2.12.1-2.22.12.12.02.1-1.71.9-1.5-1.31.6-0.7
Bone: periosteal perimeter0.50.92.3-0.7-0.80.8-0.90.91.00.81.2-0.61.50.0-0.81.30.7
Bone: post-yield work0.20.20.5-0.6-0.70.7-0.50.50.50.50.6-0.40.4-0.5-0.30.2-0.3
Progressive ratio test 1 active lever presses0.60.61.1-0.7-0.80.8-0.80.70.90.81.0-0.60.9-0.4-1.10.7-0.0
Progressive ratio test 1 breakpoint0.60.61.1-0.7-0.80.8-0.80.70.90.81.0-0.60.9-0.4-1.00.7-0.0
Progressive ratio test 1 inactive lever presses1.01.13.6-1.0-1.51.6-0.80.71.10.81.4-0.21.0-0.4-1.90.30.2
Progressive ratio test 2 active lever presses0.90.92.4-0.5-1.01.1-0.70.61.00.71.4-0.01.40.3-1.60.91.1
Progressive ratio test 2 breakpoint0.50.62.2-0.1-0.50.6-0.20.10.60.31.00.41.20.8-1.20.71.5
Progressive ratio test 2 inactive lever presses2.32.76.7-1.7-2.52.6-1.41.31.71.32.0-0.51.4-0.9-2.50.3-0.0
Incentive Sensitization - Responses0.50.52.20.70.2-0.10.7-0.7-0.5-0.7-0.11.10.11.2-0.3-0.31.5
Incentive Sensitization - Breakpoint0.60.62.50.80.2-0.10.7-0.7-0.5-0.8-0.11.20.11.3-0.3-0.31.6
Sum of active levers in priming session hrs 5-60.40.41.40.41.1-1.10.2-0.2-0.5-0.3-0.8-0.3-0.50.01.20.2-0.3
Progressive ratio0.50.61.30.40.7-0.70.6-0.6-0.8-0.7-1.00.2-1.0-0.11.2-0.9-0.7
Food seeking constrained by brief footshock1.21.45.40.60.2-0.31.1-1.0-1.2-1.2-1.41.0-2.0-0.31.0-2.3-1.1
Seeking ratio, punishment vs. effort0.30.41.0-0.7-0.91.0-0.50.60.60.60.7-0.20.3-0.5-1.0-0.0-0.2
Retroperitoneal fat weight0.51.66.61.22.4-2.60.8-0.9-1.3-0.9-1.5-0.4-0.90.51.20.4-0.5
Reaction time number correct0.40.62.5-0.5-1.31.3-0.20.30.50.30.80.40.2-0.3-1.6-0.50.1
Reaction time mean minus median1.11.56.61.01.2-1.10.4-0.3-0.1-0.40.50.31.42.0-0.71.92.6
Reaction time mean minus median AUC1.51.96.31.61.4-1.31.4-1.3-1.0-1.4-0.21.50.22.3-0.80.32.5
Reaction time num false alarms1.01.45.01.41.1-1.11.1-1.0-0.8-1.1-0.41.30.22.00.40.42.2
Reaction time num false alarms AUC0.60.83.41.00.8-0.70.8-0.7-0.5-0.8-0.11.00.31.60.10.51.8
Reaction time trials correct on left0.40.62.5-0.5-1.31.3-0.20.30.50.30.80.40.2-0.3-1.6-0.50.1
Reaction time trials on left0.40.52.6-0.5-1.21.3-0.20.20.50.30.80.40.2-0.2-1.6-0.50.1
Reaction time mean2.63.67.72.32.8-2.82.0-1.9-2.0-2.0-1.61.3-0.82.31.0-0.11.7
Reaction time mean AUC3.04.07.82.52.8-2.82.2-2.1-2.1-2.2-1.71.6-0.92.41.0-0.31.9
Median of all reaction times3.54.89.42.63.0-3.12.4-2.3-2.4-2.4-2.21.5-1.62.21.5-0.91.2
Reaction time omissions0.91.22.41.31.6-1.51.1-1.1-1.1-1.2-0.80.8-0.21.50.30.21.4
Reaction time false alarm rate0.71.02.81.11.3-1.20.8-0.7-0.6-0.8-0.40.70.41.60.70.81.7
Reaction time premature initiation rate0.20.21.00.20.3-0.3-0.10.10.10.00.20.00.70.70.11.01.0
Reaction time premature initiations0.20.20.90.0-0.20.2-0.20.10.30.10.60.20.70.5-0.70.60.9
Std. dev. reaction times1.11.54.11.41.7-1.71.1-0.9-0.8-1.1-0.20.70.41.9-0.21.02.0
Reaction time trials completed0.40.52.6-0.5-1.21.3-0.20.20.50.30.80.40.2-0.2-1.6-0.50.1
Reaction time trials AUC0.30.41.9-0.3-1.01.10.0-0.00.30.00.60.60.00.0-1.4-0.70.3
Run reversals in cocaine runway, females0.40.40.70.60.5-0.60.7-0.7-0.7-0.6-0.60.6-0.80.30.4-0.8-0.0
Run reversals in cocaine runway, males0.40.41.50.4-0.40.40.5-0.5-0.3-0.6-0.31.2-0.40.7-0.1-0.90.8
Latency to leave start box in cocaine runway0.10.10.40.30.6-0.60.2-0.1-0.3-0.2-0.3-0.10.00.20.50.40.2
Latency to leave start box in cocaine runway, F0.50.51.3-0.8-0.30.3-0.80.80.60.80.4-1.20.3-1.1-0.20.5-1.1
Latency to leave start box in cocaine runway, M1.91.94.51.61.1-1.01.4-1.3-1.2-1.4-0.91.8-0.42.00.9-0.42.1
Std. dev. time between licks in bursts0.20.31.40.1-0.30.4-0.0-0.00.20.00.60.40.60.6-1.20.31.1
Total sessions with >9 infusions0.00.00.20.00.2-0.2-0.10.10.10.10.2-0.10.30.2-0.20.40.2
Short access day 1 total inactive lever presses0.20.20.4-0.5-0.50.5-0.40.40.40.40.3-0.40.0-0.6-0.7-0.0-0.6
Short access day 10 total inactive lever presses3.23.55.9-2.3-2.32.2-2.02.01.81.81.5-1.80.9-2.4-1.40.6-2.1
Short access day 1 total infusions1.11.12.80.71.0-1.10.8-0.9-1.1-0.8-1.50.3-1.7-0.31.2-1.4-1.2
Short access day 10 total infusions1.01.11.71.21.1-1.11.2-1.3-1.1-1.1-1.01.1-1.11.00.9-1.10.5
Short access total infusions0.40.51.30.51.0-1.10.3-0.4-0.5-0.2-0.9-0.2-0.8-0.11.1-0.3-0.7
Short access day 1 locomotion1.21.32.91.41.7-1.71.0-1.0-1.1-1.0-0.90.7-0.41.41.10.21.2
Short access day 10 total locomotion0.30.30.70.40.5-0.50.5-0.5-0.6-0.5-0.60.3-0.80.00.8-0.7-0.4
Short access total locomotion0.80.92.21.01.5-1.50.8-0.8-0.9-0.7-1.00.3-0.70.71.4-0.20.2
One hour access (0.3 mA shock)0.60.72.10.4-0.60.70.7-0.7-0.3-0.70.31.5-0.01.0-1.0-0.91.3
Compulsive drug intake3.73.75.12.01.7-1.72.3-2.2-2.2-2.2-2.12.1-2.11.51.6-2.10.7
One hour access (shock baseline)1.01.22.7-0.7-1.21.3-0.80.71.10.81.5-0.01.50.3-1.60.91.2
Social response proportion5.15.511.7-1.9-1.61.7-2.42.52.62.42.9-2.13.3-0.7-2.73.40.7
Social responses1.72.25.8-1.1-1.51.5-1.31.41.51.21.9-0.52.0-0.1-2.41.61.0
Social time3.14.16.72.52.2-2.12.3-2.3-2.1-2.3-1.62.2-1.22.60.8-0.92.2
Soleus weight1.33.95.8-2.2-2.42.4-2.12.12.32.22.2-1.62.0-1.6-1.71.5-0.6
Bone: stiffness0.50.82.2-0.5-0.70.7-0.80.70.90.81.2-0.41.50.2-1.01.30.9
Tibialis anterior weight6.622.429.7-4.9-4.44.3-5.45.35.45.35.3-4.85.4-3.4-4.05.2-1.1
Time to tail flick, vehicle, before self-admin0.91.02.71.11.6-1.60.6-0.7-0.7-0.5-0.70.3-0.11.21.30.61.0
Time to tail flick, vehicle, after self-admin0.60.61.91.00.8-0.80.8-0.7-0.7-0.8-0.40.9-0.01.30.40.11.4
Time to tail flick, test, before self-admin0.70.71.0-1.0-1.01.0-0.80.90.90.90.8-0.80.8-0.8-0.70.6-0.6
Time to tail flick, test, after self-admin0.30.31.1-0.50.2-0.2-0.60.60.30.50.1-1.00.3-0.70.50.8-0.7
Delta time to tail flick, vehicle, before/after SA0.50.51.10.60.1-0.10.9-0.7-0.8-0.9-0.61.1-0.70.60.3-1.10.4
Delta time to tail flick, test, before/after SA0.20.20.50.30.6-0.60.2-0.2-0.4-0.2-0.5-0.1-0.6-0.10.7-0.2-0.4
Tibia length5.114.320.2-4.3-3.53.4-4.54.44.14.33.5-4.43.3-3.9-2.73.4-2.7
Ambulatory time before self-admin0.60.62.90.80.8-0.80.4-0.5-0.2-0.40.00.60.61.4-0.20.81.7
Ambulatory time after self-admin0.30.41.20.70.5-0.50.6-0.6-0.4-0.5-0.20.80.11.00.0-0.01.1
Bone: tissue strength0.50.42.1-0.5-0.70.6-0.10.10.10.2-0.1-0.2-0.8-1.1-0.4-1.1-1.4
Total heroin consumption5.36.38.93.02.8-2.82.6-2.6-2.6-2.7-2.42.5-1.53.02.1-1.22.4
Bone: trabecular number4.67.39.9-3.2-3.03.0-3.03.02.92.92.7-2.72.2-2.8-2.41.7-1.9
Bone: trabecular spacing3.44.45.72.32.2-2.22.4-2.3-2.4-2.4-2.42.0-2.11.72.0-1.80.8
Bone: trabecular thickness5.06.07.8-2.8-2.62.6-2.72.72.72.72.6-2.52.2-2.4-2.01.9-1.5
Bone: trabecular tissue density1.01.45.00.91.4-1.40.2-0.20.0-0.10.60.01.41.8-0.42.12.2
Water consumed over 24 hours2.83.35.5-2.0-2.32.4-2.01.92.12.02.1-1.41.5-1.6-1.70.9-0.8
Number of responses in last shaping day0.10.10.3-0.3-0.40.4-0.20.20.30.30.4-0.10.1-0.3-0.6-0.1-0.2