Dnaja1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Dnaja1	0.03	0.02	4.9e-03	0.02	0.01	0	0.01	3.3e-03	1.4e-02	7.2e-02	1.0e-02
2	Adipose	gene expression	Dnaja1	0.15	0.09	1.3e-12	0.1	0.1	0.1	0.1	5.2e-11	1.1e-10	4.7e-11	8.6e-11
3	NAcc	gene expression	Dnaja1	0.03	0.02	5.0e-05	0.02	0.03	0.02	0.02	4.5e-04	6.0e-05	5.9e-04	2.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.8	1.4	2.2	1.4	1.5	-0.2
Area under the delay curve	0.2	0.3	0.4	-0.6	-0.6	0.1
BMI with tail	0.7	2.4	3.7	1.7	1.9	-0.9
BMI without tail	1.1	3.2	4.1	2.0	2.0	-1.2
Body weight	2.5	11.1	12.3	3.5	3.5	-2.9
Weight adjusted by age	0.6	0.9	1.5	0.9	0.5	-1.2
Bone surface	0.7	1.2	1.5	1.2	1.2	-0.8
Bone volume	0.5	0.9	1.2	1.1	1.1	-0.4
Breakpoint value in progressive ratio session	0.8	0.9	1.3	-0.5	-1.1	-1.1
Number of licking bursts	4.0	6.6	9.7	2.8	3.1	-1.4
Context. condit. distance diff. score	0.2	0.2	0.3	-0.5	-0.5	0.5
Locomotion velocity, session 1	2.7	3.0	8.0	0.8	0.4	-2.8
Locomotion distance, session 1	1.0	1.2	3.0	0.7	0.4	-1.7
Locomotion velocity, session 2	1.3	1.6	2.3	1.4	1.5	-0.6
Locomotion distance, session 2	2.3	3.2	3.9	1.8	1.7	-2.0
Locomotion velocity, session 3	0.4	0.5	1.5	0.1	-0.0	-1.2
Locomotion distance, session 3	1.4	1.5	2.5	1.1	1.0	-1.6
Stereotopy head waving bouts, day 3	0.4	0.4	1.0	0.4	0.4	-1.0
Stereotopy head waving duration, day 3	0.1	0.2	0.2	0.3	0.5	-0.4
Locomotion velocity, session 7	0.2	0.2	0.3	-0.6	-0.5	0.2
Locomotion distance, session 7	0.1	0.2	0.4	0.2	0.3	-0.6
Stereotopy head waving bouts, day 7	2.5	2.8	3.4	1.8	1.8	-1.4
Stereotopy head waving duration, day 7	1.7	2.1	2.7	1.6	1.6	-1.0
Locomotion velocity, session 8	0.9	1.0	2.2	0.7	0.6	-1.5
Locomotion distance, session 8	0.5	0.7	1.6	0.6	0.5	-1.2
Degree of sensitization distance	0.5	0.5	0.6	-0.7	-0.6	0.8
Degree of sensitization stereotypy	2.1	2.3	2.9	1.7	1.7	-1.0
Conditioned locomotion	0.2	0.3	0.8	0.2	0.0	-0.9
Cocaine response after cond. corrected	0.4	0.5	0.6	-0.7	-0.8	-0.6
Cocaine response after cond. not corrected	0.4	0.5	1.0	-0.3	-0.5	-1.0
Cocaine response before conditioning	1.0	1.2	1.6	1.2	1.2	-0.7
Saline control response	2.9	3.8	4.2	2.0	1.8	-2.0
Bone: connectivity density	0.3	0.4	0.6	0.7	0.8	0.2
Bone: cortical apparent density	0.2	0.3	0.8	-0.1	0.0	0.9
Bone: cortical area	1.9	2.9	4.5	2.0	2.1	-0.4
Bone: cortical porosity	0.1	0.1	0.2	-0.0	-0.1	0.4
Bone: cortical porosity	0.1	0.1	0.2	0.5	0.4	-0.2
Bone: cortical thickness	0.7	1.2	1.9	1.2	1.4	0.5
Bone: cortical thickness	0.2	0.3	0.8	-0.2	-0.0	0.9
Bone: cortical tissue density	0.2	0.2	0.7	-0.2	-0.1	0.8
Condit. Reinf. active minus inactive responses	0.3	0.3	0.4	0.6	0.6	-0.5
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.2	-1.0	-1.1	0.9
Condit. Reinf. active responses	2.2	2.7	3.3	1.8	1.8	-1.2
Condit. Reinf. inactive responses	2.7	3.3	4.3	2.1	2.1	-1.1
Incentive salience index mean	3.8	4.7	5.4	2.3	2.3	-1.9
Condit. Reinf. lever presses	11.3	15.9	17.8	4.2	4.1	-3.6
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	0.8	0.7	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	0.1	0.4
Condit. Reinf. active responses	1.1	1.5	2.0	1.4	1.4	-0.8
Condit. Reinf. inactive responses	1.4	1.8	2.5	1.6	1.6	-0.6
Condit. Reinf. lever presses	0.9	1.2	2.1	1.3	1.4	-0.1
Condit. Reinf. lever reinforcers received	1.3	1.8	2.3	1.5	1.5	-0.9
Conditioned reinforcement - actives	0.0	0.0	0.1	0.3	0.2	0.1
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.2	0.0	-0.2
Conditioned locomotion	0.0	0.0	0.1	0.0	0.2	-0.2
Patch foraging indifference point 0 sec	1.1	2.1	5.5	0.7	0.5	-2.3
Patch foraging indifference point AUC	3.9	5.7	6.6	2.6	2.5	-2.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.3	-0.5	-0.1
Delay disc. indifference point, 16s delay	0.7	0.7	1.2	-1.0	-1.1	-0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.3	0.5	0.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.5	-0.5	0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	-0.3	0.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.1	0.1
Indifference point function ln k	0.9	1.6	2.1	-1.4	-1.4	0.8
Indifference point function log k	0.9	1.6	2.1	-1.4	-1.4	0.8
Patch foraging total patch changes 0 sec	1.7	3.1	6.4	1.3	1.1	-2.5
Patch foraging total patch changes 12 sec	0.7	1.0	1.0	1.0	1.0	-1.0
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	0.2	0.2	-0.8
Patch foraging total patch changes 24 sec	1.6	2.8	3.2	1.8	1.5	-1.7
Patch foraging total patch changes 6 sec	2.4	3.7	6.1	1.6	1.6	-2.5
Patch foraging time to switch 0 sec	2.5	5.1	5.6	-2.4	-2.2	2.2
Patch foraging water rate 0 sec	1.7	3.5	4.2	1.8	1.7	-2.1
Patch foraging water rate 12 sec	0.2	0.5	0.6	0.7	0.7	-0.8
Patch foraging water rate 18 sec	0.5	0.8	1.3	1.1	1.1	0.2
Patch foraging water rate 24 sec	0.2	0.3	0.4	0.5	0.6	0.6
Patch foraging water rate 6 sec	2.3	3.3	4.5	2.1	2.0	-1.2
Seeking ratio, delayed vs. immediate footshock	1.7	2.0	2.9	1.7	1.5	-1.0
Distance traveled before self-admin	6.5	8.6	10.1	3.0	3.2	-2.6
Distance traveled after self-admin	3.7	4.5	7.1	2.3	2.7	-1.0
Extensor digitorum longus weight	4.5	17.7	22.6	4.6	4.8	-3.0
Bone: elastic displacement	7.3	8.4	9.3	-3.0	-3.1	2.6
Bone: elastic work	4.8	6.2	10.0	-2.2	-2.0	3.2
Bone: endosteal estimation	1.0	2.1	2.9	1.3	1.3	-1.7
Bone: endosteal perimeter	1.1	2.3	3.2	1.4	1.3	-1.8
Epididymis fat weight	0.1	0.4	0.7	0.7	0.8	-0.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.5	-0.1	0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.1	-0.4	-0.2
Diff in mean of infusions in LGA sessions	0.8	1.0	1.2	-1.0	-1.0	1.1
Delay discount exponential model param	0.2	0.3	0.4	0.6	0.6	-0.1
Extinction: sum of active levers before priming	1.6	1.8	2.6	-1.5	-1.6	0.8
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.2	-0.2	0.2
Bone: final force	1.5	2.5	3.4	1.8	1.8	-0.9
Bone: final moment	1.0	1.7	2.5	1.5	1.6	-0.5
Food consumed during 24 hour testing period	1.5	2.1	2.3	1.4	1.4	-1.5
Glucose	1.3	2.0	2.2	1.4	1.5	-1.3
Heart weight	0.4	0.6	0.9	0.7	0.9	-0.5
Delay discount hyperbolic model param	0.2	0.2	0.3	0.6	0.5	-0.0
Intermittent access intake day 1-15 change	0.0	0.1	0.1	0.3	0.3	-0.1
Intermittent access intake escalation	0.0	0.0	0.1	0.2	0.3	0.1
Intermittent access intake escalation 2	0.3	0.3	0.5	0.6	0.7	0.3
Intermitt. access day 1 inactive lever presses	0.3	1.2	1.4	1.2	0.9	-1.1
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.4	0.7	0.3	-0.5
Intermitt. access escalation Index	0.1	0.2	0.2	0.4	0.4	-0.4
Intermittent access day 1 total infusions	1.1	1.8	2.5	-1.5	-1.6	0.6
Intermittent access day 15 total infusions	0.2	0.3	0.3	-0.5	-0.5	0.6
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.3	0.2	-0.1
Intermittent access total infusions	0.0	0.0	0.1	-0.2	-0.2	-0.0
Intermittent access day 1 locomotion	0.9	1.2	1.7	-1.3	-1.3	0.5
Intermittent access day 15 total locomotion	1.3	2.4	3.5	-1.9	-1.7	0.8
Intermittent access total locomotion	1.7	2.1	2.6	-1.6	-1.4	1.2
Intermittent access standard deviation	0.0	0.1	0.2	0.1	0.1	-0.4
Left kidney weight	1.1	5.1	7.0	2.1	1.9	-2.6
Right kidney weight	0.4	1.6	1.7	1.3	1.2	-1.3
Cocaine induced anxiety	1.0	1.4	1.8	1.3	1.4	-0.9
Post-drug Anxiety	4.0	4.3	5.0	2.2	2.2	-1.8
Baseline Anxiety	0.3	0.3	0.5	0.6	0.7	-0.3
Tail length	1.4	5.4	6.5	2.5	2.5	-1.9
Length with tail	1.7	7.5	8.8	2.7	2.5	-3.0
Length without tail	0.4	1.2	2.4	0.7	0.7	-1.5
Times rat made contact with spout	0.3	0.4	0.6	0.6	0.8	-0.0
Lifetime Intake	0.1	0.1	0.2	-0.1	-0.1	-0.4
Liver weight, left	0.2	0.4	0.5	0.5	0.6	-0.7
Liver weight, right	0.7	1.2	1.4	-1.2	-1.1	1.0
Locomotor activity	0.1	0.1	0.1	-0.4	-0.4	0.2
Locomotor testing distance	0.1	0.1	0.2	-0.2	-0.3	-0.5
Locomotor testing rearing	0.4	0.8	0.9	0.9	0.8	-1.0
Locomotion in novel chamber	0.2	0.3	0.4	0.6	0.7	0.1
Locomotion in novel chamber post-restriction	0.9	1.4	2.9	1.2	1.7	-0.0
Fecal boli incidents, locomotor time 1	2.3	3.3	4.4	-1.9	-2.1	1.3
Change in fecal boli incidents, locomotor task	1.6	1.6	1.8	1.4	1.1	-1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.3	0.1	-0.5
Bouts of movement, locomotor time 1	1.1	1.2	1.4	-1.2	-1.2	1.0
Total resting periods, locomotor time 1	2.5	2.8	2.9	-1.7	-1.7	1.6
Rest time, locomotor task time 1	2.6	3.2	5.4	-1.7	-1.3	2.3
Distance moved, locomotor task time 1	2.0	3.0	4.7	1.6	1.3	-2.2
Vertical activity count, locomotor time 1	1.3	3.2	5.2	1.7	1.2	-2.3
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	0.6	0.2	-0.5
Bouts of movement, locomotor time 2	0.4	0.6	0.9	1.0	0.7	-0.5
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.6	0.3	-0.2
Rest time, locomotor task time 2	1.1	1.3	1.5	-1.2	-1.0	1.2
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.3	0.4	-0.0
Vertical activity count, locomotor time 2	0.6	0.9	1.1	1.1	0.7	-1.0
Light reinforcement 1	1.5	3.6	7.5	1.4	1.3	-2.7
Light reinforcement 2	1.7	2.6	5.8	1.1	0.9	-2.4
Bone: marrow area	0.9	2.0	2.4	1.3	1.3	-1.5
Bone: maximum diameter	2.0	3.8	5.3	2.2	2.3	-1.1
Bone: maximum force	3.0	5.4	7.5	2.6	2.7	-1.4
Bone: maximum moment	2.2	3.9	5.7	2.2	2.4	-1.0
Mean time between licks in bursts	0.2	0.4	0.6	-0.7	-0.7	0.4
Mean num. licks in bursts	2.6	4.0	5.3	-2.2	-2.3	1.4
Cd content in liver	1.2	1.3	1.9	1.3	1.4	-0.7
Co content in liver	0.3	0.4	0.6	-0.6	-0.8	-0.3
Cu content in liver	1.1	1.3	1.5	-1.2	-1.2	1.0
Fe content in liver	0.3	0.4	0.6	-0.6	-0.8	-0.4
K content in liver	0.1	0.1	0.2	-0.4	-0.5	-0.2
Mg content in liver	0.9	0.9	1.3	-1.1	-1.1	0.6
Mn content in liver	1.6	1.8	3.0	1.5	1.7	-0.3
Na content in liver	1.1	1.2	1.2	-1.1	-1.1	1.1
Rb content in liver	4.4	5.1	7.0	-2.6	-2.6	1.3
Se content in liver	2.2	2.6	4.0	1.9	2.0	-0.6
Sr content in liver	0.5	0.4	0.7	0.8	0.8	-0.2
Zn content in liver	0.0	0.0	0.1	-0.1	-0.0	0.3
Bone: minimum diameter	0.1	0.3	0.4	-0.5	-0.4	0.6
Time in familiar zone, hab. session 1	2.0	1.9	5.1	-0.8	-0.3	2.3
Time in novel zone, hab. session 1	1.2	1.2	1.6	-0.8	-1.3	-1.1
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.2	-0.2	0.1
Total locomotion distance, hab. session 1	0.3	0.4	0.6	0.5	0.8	0.7
Locomotion velocity, hab. session 1	0.9	1.3	2.3	1.3	1.5	0.0
Time in familiar zone, hab. session 2	2.1	2.2	3.9	-1.3	-1.0	2.0
Time in novel zone, hab. session 2	0.5	0.5	1.0	-0.4	-0.7	-1.0
Total zone transitions, hab. session 2	1.3	1.7	2.7	1.2	1.0	-1.6
Total locomotion distance, hab. session 2	1.0	1.4	1.7	1.3	1.3	-0.8
Locomotion velocity, hab. session 2	1.1	1.4	1.9	1.3	1.4	-0.8
Novel to familiar place preference ratio	2.5	2.7	4.6	-1.9	-2.2	0.3
Novelty place preference	3.5	3.7	5.9	-2.2	-2.4	0.7
Time in novel zone, NPP test	4.1	4.4	7.0	-2.4	-2.6	0.7
Total zone transitions, NPP test	1.2	1.7	2.6	1.2	1.0	-1.6
Total locomotion distance, NPP test	2.2	3.0	3.1	1.7	1.7	-1.8
Locomotion velocity, NPP test	2.3	3.2	3.4	1.8	1.8	-1.7
Intraocular pressure	1.6	2.3	2.6	1.6	1.5	-1.4
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.1	0.1	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.1	-0.1	0.4
Parametrial fat weight	0.1	0.2	0.4	-0.2	-0.5	-0.6
Pavlov. Cond. lever latency	8.1	10.2	11.6	-3.3	-3.4	2.8
Pavlov. Cond. magazine entry latency	0.4	0.5	0.6	0.7	0.8	-0.7
Pavlov. Cond. change in total contacts	2.9	3.1	3.4	1.8	1.7	-1.8
Pavlov. Cond. index score	3.4	4.3	5.2	2.2	2.3	-1.7
Pavlov. Cond. latency score	3.1	4.0	4.7	2.1	2.2	-1.7
Pavlov. Cond. lever contacts	7.6	9.1	10.6	3.2	3.3	-2.5
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	-0.9	-0.9	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.3	0.4	-0.2
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	4.6	2.1	2.1	-1.4
Pavlov. Cond. response bias	4.2	5.2	6.0	2.4	2.5	-1.9
Pavlov. Cond. lever latency	0.8	1.1	1.9	-1.2	-1.4	0.1
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	-0.7	-0.6	0.9
Pavlov. Cond. change in total contacts	0.3	0.5	1.3	0.1	0.4	1.1
Pavlov. Cond. index score	0.2	0.3	0.8	-0.1	0.1	0.9
Pavlov. Cond. latency score	0.2	0.3	0.8	0.0	0.2	0.9
Pavlov. Cond. lever contacts	0.5	0.7	1.3	1.0	1.1	0.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.4	0.3	0.0	-1.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	0.9	0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.0	-0.2	0.0	1.0
Pavlov. Cond. response bias	0.2	0.3	0.4	0.4	0.6	0.6
Time in closed arm before self-admin	0.4	0.6	0.6	-0.8	-0.8	0.7
Time in closed arm after self-admin	0.6	0.6	0.8	-0.9	-0.5	0.9
Time in open arm before self-admin	1.7	1.9	2.5	1.3	1.2	-1.6
Time in open arm after self-admin	1.4	1.5	1.8	1.3	1.0	-1.3
Bone: periosteal estimation	1.4	3.0	3.8	1.9	1.9	-1.3
Bone: periosteal perimeter	0.7	1.2	1.6	1.1	1.0	-1.3
Bone: post-yield work	2.7	3.9	4.2	1.9	2.1	-2.0
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.1	-0.4	-0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.0	-0.3	-0.4
Progressive ratio test 1 inactive lever presses	1.0	1.4	2.4	1.1	0.7	-1.6
Progressive ratio test 2 active lever presses	0.3	0.4	0.7	-0.6	-0.8	-0.2
Progressive ratio test 2 breakpoint	0.4	0.4	0.8	-0.6	-0.9	-0.2
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	0.2	-0.0	-0.4
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.3	-0.4	-0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.5	-0.6	-0.1
Sum of active levers in priming session hrs 5-6	2.8	2.6	4.3	-1.8	-2.1	0.2
Progressive ratio	0.0	0.1	0.1	-0.2	-0.4	-0.2
Food seeking constrained by brief footshock	11.5	14.1	15.8	4.0	3.8	-3.5
Seeking ratio, punishment vs. effort	3.2	4.6	5.7	2.4	2.4	-1.6
Retroperitoneal fat weight	0.5	2.2	2.4	-1.6	-1.4	1.4
Reaction time number correct	0.0	0.1	0.2	-0.1	-0.3	-0.4
Reaction time mean minus median	0.6	1.6	4.4	-0.6	-0.1	2.1
Reaction time mean minus median AUC	0.3	0.7	1.8	0.1	0.6	1.4
Reaction time num false alarms	0.2	0.2	0.6	-0.2	0.1	0.8
Reaction time num false alarms AUC	0.1	0.2	0.4	0.4	0.6	0.0
Reaction time trials correct on left	0.0	0.1	0.2	-0.1	-0.3	-0.4
Reaction time trials on left	0.1	0.1	0.2	-0.2	-0.4	-0.3
Reaction time mean	3.0	4.7	7.5	-2.0	-1.6	2.7
Reaction time mean AUC	3.2	5.2	8.4	-2.1	-1.6	2.9
Median of all reaction times	3.6	5.1	5.9	-2.3	-2.0	2.4
Reaction time omissions	2.7	3.9	4.9	-2.2	-2.2	1.5
Reaction time false alarm rate	0.1	0.2	0.4	-0.1	0.2	0.7
Reaction time premature initiation rate	4.3	6.0	6.8	-2.6	-2.4	2.3
Reaction time premature initiations	2.6	4.7	5.7	-2.4	-2.3	1.8
Std. dev. reaction times	1.6	3.0	6.6	-1.3	-0.8	2.6
Reaction time trials completed	0.1	0.1	0.2	-0.2	-0.4	-0.3
Reaction time trials AUC	0.1	0.1	0.2	-0.2	-0.4	-0.3
Run reversals in cocaine runway, females	0.3	0.3	0.8	-0.5	-0.2	0.9
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.4	-0.3	0.3
Latency to leave start box in cocaine runway	0.9	1.1	1.5	1.1	1.2	-0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.3	-0.3	-0.4
Latency to leave start box in cocaine runway, M	5.1	4.7	6.1	2.5	2.5	-1.4
Std. dev. time between licks in bursts	0.7	1.0	1.2	-1.1	-1.0	0.9
Total sessions with >9 infusions	0.1	0.2	0.4	0.1	0.1	-0.7
Short access day 1 total inactive lever presses	1.6	2.2	3.6	1.3	1.1	-1.9
Short access day 10 total inactive lever presses	0.4	1.1	1.3	1.1	1.1	-0.9
Short access day 1 total infusions	0.5	0.6	1.5	0.4	0.4	-1.2
Short access day 10 total infusions	0.2	0.2	0.3	-0.3	-0.6	-0.5
Short access total infusions	0.2	0.2	0.5	-0.1	-0.3	-0.7
Short access day 1 locomotion	1.4	1.7	2.7	-1.6	-1.5	0.5
Short access day 10 total locomotion	1.4	2.7	3.1	-1.8	-1.4	1.7
Short access total locomotion	0.9	1.0	1.6	-1.3	-1.0	0.6
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.4	-0.6	-0.3
Compulsive drug intake	0.1	0.1	0.2	-0.1	-0.2	0.5
One hour access (shock baseline)	0.2	0.3	0.8	-0.2	-0.3	-0.9
Social response proportion	0.8	0.9	1.1	-0.9	-1.0	1.0
Social responses	0.5	0.7	0.8	0.9	0.8	-0.7
Social time	0.1	0.1	0.1	-0.3	-0.4	-0.2
Soleus weight	0.4	1.2	3.3	0.3	0.0	-1.8
Bone: stiffness	4.2	6.8	9.1	2.9	3.0	-1.6
Tibialis anterior weight	7.3	24.6	29.0	5.3	5.4	-4.1
Time to tail flick, vehicle, before self-admin	1.9	2.0	2.5	-1.6	-1.5	1.1
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	-0.0	0.3
Time to tail flick, test, before self-admin	0.4	0.4	0.6	0.8	0.7	-0.4
Time to tail flick, test, after self-admin	0.2	0.3	0.4	0.4	0.4	0.7
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.8	0.9	0.8	-0.6
Delta time to tail flick, test, before/after SA	0.8	0.8	1.1	-0.9	-0.7	1.0
Tibia length	0.7	1.9	3.2	1.2	1.0	-1.8
Ambulatory time before self-admin	4.6	6.8	7.6	2.7	2.8	-2.4
Ambulatory time after self-admin	3.4	4.0	5.1	2.1	2.3	-1.5
Bone: tissue strength	0.1	0.1	0.1	0.3	0.3	-0.1
Total heroin consumption	0.7	0.8	1.5	-1.0	-1.2	0.1
Bone: trabecular number	0.6	1.0	1.6	1.2	1.3	-0.2
Bone: trabecular spacing	0.1	0.1	0.1	0.3	0.3	0.3
Bone: trabecular thickness	0.1	0.2	0.3	-0.4	-0.3	0.5
Bone: trabecular tissue density	3.8	5.6	7.6	2.6	2.8	-1.6
Water consumed over 24 hours	1.6	2.2	2.8	1.6	1.7	-1.1
Number of responses in last shaping day	1.4	1.5	3.9	0.7	0.3	-2.0