Hub : Genes

Ints9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Ints9 0.08 0.07 6.7e-07 0.06 0.06 0.06 0.06 2.5e-07 2.9e-07 3.1e-07 3.7e-07
2 IC mRNA stability Ints9 0.07 0.05 1.9e-03 0.03 0.03 0 0.03 2.8e-02 1.8e-02 2.7e-01 3.0e-02
3 pVTA mRNA stability Ints9 0.07 0.04 2.0e-07 0.05 0.07 0.06 0.06 5.7e-05 1.6e-06 7.0e-06 9.9e-06
4 Brain mRNA stability Ints9 0.31 0.12 0.0e+00 0.26 0.29 0.28 0.27 1.2e-24 3.6e-27 2.5e-26 1.7e-25
5 NAcc alternative polyA NM_001402259.1 0.02 0.02 7.2e-03 0.01 0.01 0.01 0.01 2.8e-03 5.8e-03 9.3e-03 2.9e-03
6 NAcc alternative polyA XM_063274137.1 0.02 0.02 6.1e-03 0.02 0.01 0.01 0.01 9.6e-04 7.6e-03 6.2e-03 3.7e-03
7 NAcc mRNA stability Ints9 0.04 0.02 3.0e-08 0.06 0.05 0.05 0.06 2.1e-09 2.2e-08 1.9e-08 9.6e-09
8 OFC alternative polyA NM_001402259.1 0.21 0.13 7.4e-03 0.07 0 0 0.01 9.4e-03 3.3e-01 3.2e-01 1.7e-01
9 OFC alternative polyA XM_063274137.1 0.21 0.13 8.3e-03 0.08 0 -0 0.03 7.5e-03 2.5e-01 3.7e-01 8.0e-02
10 PL mRNA stability Ints9 0.05 0.03 6.4e-05 0.04 0.03 0.03 0.04 1.4e-05 2.4e-04 2.9e-04 4.5e-05
11 Liver gene expression Ints9 0.15 0.07 4.8e-14 0.1 0.08 0.09 0.09 9.9e-11 3.3e-09 8.0e-10 1.0e-09
12 IL mRNA stability Ints9 0.3 0.2 1.8e-03 0.02 0.03 0.01 0.01 1.1e-01 8.2e-02 2.1e-01 1.5e-01
13 NAcc intron excision ratio chr15_43410312_43415357 0.06 0.05 7.9e-03 0 0.01 0 0 8.9e-02 4.0e-02 4.4e-02 6.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.30.62.3-1.5-1.3-0.9-0.9-0.90.90.2-0.70.70.3-0.2-0.0-0.0
Area under the delay curve3.04.610.12.82.91.61.13.2-3.2-0.73.1-3.1-0.60.40.2-0.2
BMI with tail0.20.71.61.11.31.00.90.9-0.9-0.80.7-0.7-0.90.50.60.4
BMI without tail0.00.00.2-0.2-0.1-0.2-0.4-0.00.0-0.1-0.20.20.1-0.0-0.1-0.5
Body weight0.72.95.61.91.92.32.10.3-0.3-2.30.1-0.1-2.42.02.01.3
Weight adjusted by age1.13.15.61.31.02.12.2-1.21.2-2.3-1.21.2-2.12.42.11.6
Bone surface0.20.51.9-1.4-1.1-0.7-0.7-0.70.70.1-0.60.60.2-0.1-0.0-0.1
Bone volume0.10.31.1-1.1-0.7-0.7-0.90.0-0.00.40.2-0.20.5-0.4-0.3-0.5
Breakpoint value in progressive ratio session0.61.02.81.21.20.60.41.4-1.4-0.11.7-1.7-0.10.20.0-0.2
Number of licking bursts0.10.41.30.60.70.30.41.1-1.10.11.0-1.00.2-0.10.00.3
Context. condit. distance diff. score2.73.35.9-1.4-1.0-2.1-2.01.2-1.22.41.3-1.32.4-2.4-2.3-1.5
Locomotion velocity, session 10.10.10.20.20.40.2-0.10.4-0.4-0.10.3-0.3-0.20.00.0-0.2
Locomotion distance, session 10.00.00.1-0.10.00.1-0.20.4-0.4-0.00.0-0.0-0.10.10.0-0.2
Locomotion velocity, session 20.30.31.20.40.50.1-0.11.1-1.10.20.8-0.80.2-0.2-0.2-0.3
Locomotion distance, session 20.10.10.2-0.3-0.3-0.1-0.3-0.30.3-0.1-0.50.5-0.20.20.2-0.1
Locomotion velocity, session 30.70.81.80.91.01.21.0-0.20.2-1.3-0.30.3-1.31.31.00.2
Locomotion distance, session 30.20.20.70.60.80.60.50.2-0.2-0.40.4-0.4-0.50.40.3-0.1
Stereotopy head waving bouts, day 31.01.22.2-0.1-0.60.40.8-1.51.5-0.9-1.41.4-0.91.01.01.3
Stereotopy head waving duration, day 30.81.02.01.10.51.11.1-0.60.6-1.4-0.70.7-1.41.41.20.7
Locomotion velocity, session 72.22.45.1-1.3-1.0-1.9-1.60.9-0.92.21.2-1.22.2-2.3-1.8-0.6
Locomotion distance, session 72.63.36.0-2.1-1.6-2.4-2.40.6-0.62.40.7-0.72.4-2.4-2.1-1.2
Stereotopy head waving bouts, day 71.41.62.81.51.11.61.6-0.80.8-1.6-0.40.4-1.51.71.50.9
Stereotopy head waving duration, day 72.43.05.32.01.52.22.3-0.70.7-2.3-0.60.6-2.12.32.01.4
Locomotion velocity, session 80.50.61.40.10.4-0.3-0.51.2-1.20.71.0-1.00.8-0.6-0.7-0.9
Locomotion distance, session 80.91.22.1-0.9-0.6-1.3-1.40.8-0.81.40.8-0.81.4-1.4-1.3-1.1
Degree of sensitization distance5.15.510.2-2.7-2.5-3.2-2.90.5-0.53.10.6-0.63.1-3.1-2.6-1.3
Degree of sensitization stereotypy0.70.82.51.61.41.31.10.1-0.1-1.00.5-0.5-0.81.00.70.1
Conditioned locomotion0.70.91.6-0.7-0.8-1.2-1.10.6-0.61.20.6-0.61.3-1.2-1.1-0.8
Cocaine response after cond. corrected1.11.72.7-0.10.1-1.0-1.21.6-1.61.31.6-1.61.2-1.3-1.5-1.5
Cocaine response after cond. not corrected0.81.21.9-0.10.3-0.7-1.01.3-1.31.01.4-1.41.0-1.0-1.1-1.3
Cocaine response before conditioning0.81.01.60.10.30.91.0-1.01.0-1.1-1.11.1-0.91.11.31.2
Saline control response0.40.50.80.20.00.60.7-0.70.7-0.8-0.90.9-0.80.70.80.9
Bone: connectivity density1.72.85.9-2.4-2.3-1.0-0.4-2.32.3-0.2-2.32.3-0.10.30.71.5
Bone: cortical apparent density0.20.30.60.50.70.40.40.8-0.8-0.20.7-0.7-0.10.10.10.0
Bone: cortical area1.22.05.81.21.40.50.12.2-2.20.32.4-2.40.3-0.3-0.4-0.8
Bone: cortical porosity1.01.12.11.51.41.31.30.9-0.9-0.90.9-0.9-0.70.80.80.6
Bone: cortical porosity1.01.12.31.51.31.41.30.7-0.7-1.10.7-0.7-1.01.00.90.6
Bone: cortical thickness1.62.77.21.62.00.90.62.5-2.50.12.7-2.70.2-0.2-0.3-0.5
Bone: cortical thickness4.35.311.91.11.7-0.3-0.83.5-3.51.83.4-3.41.8-1.8-1.9-1.8
Bone: cortical tissue density0.10.20.50.40.60.30.30.7-0.7-0.10.6-0.6-0.10.10.1-0.1
Condit. Reinf. active minus inactive responses0.40.40.80.60.40.80.9-0.60.6-0.7-0.30.3-0.70.60.70.8
Condit. Reinf. active-inactive response ratio0.10.10.30.2-0.20.10.2-0.50.5-0.3-0.40.4-0.30.20.30.3
Condit. Reinf. active responses0.30.41.10.70.60.91.0-0.40.4-0.6-0.10.1-0.70.60.81.0
Condit. Reinf. inactive responses0.30.41.70.10.30.70.9-0.40.4-0.5-0.20.2-0.50.50.81.3
Incentive salience index mean1.01.33.01.31.31.61.7-0.20.2-1.20.1-0.1-1.31.21.31.3
Condit. Reinf. lever presses1.01.53.51.31.71.81.90.2-0.2-1.20.4-0.4-1.41.21.31.3
Condit. Reinf. active minus inactive responses0.20.30.8-0.4-0.5-0.7-0.60.1-0.10.90.1-0.10.9-0.9-0.8-0.2
Condit. Reinf. active-inactive response ratio0.10.10.3-0.2-0.2-0.4-0.4-0.10.10.5-0.20.20.4-0.5-0.5-0.3
Condit. Reinf. active responses0.30.41.0-0.5-0.6-0.9-0.9-0.10.10.90.1-0.11.0-0.9-0.8-0.5
Condit. Reinf. inactive responses0.50.71.4-1.1-1.1-1.2-1.2-0.10.11.00.1-0.11.2-1.0-0.9-0.4
Condit. Reinf. lever presses0.40.71.6-0.1-0.30.40.3-1.31.3-0.8-1.11.1-0.70.80.70.3
Condit. Reinf. lever reinforcers received0.10.20.5-0.2-0.3-0.5-0.6-0.10.10.60.1-0.10.7-0.6-0.6-0.4
Conditioned reinforcement - actives1.04.07.1-2.7-2.4-2.5-2.5-1.91.91.9-1.61.61.8-1.7-1.7-1.5
Conditioned reinforcement - inactives0.82.24.6-2.0-1.8-0.9-0.2-2.12.10.5-2.12.10.3-0.20.41.5
Conditioned locomotion1.42.13.9-1.0-0.6-1.7-1.90.8-0.81.80.8-0.81.7-1.9-2.0-1.8
Patch foraging indifference point 0 sec0.41.12.80.1-0.20.81.0-1.11.1-0.9-1.21.2-1.10.81.31.7
Patch foraging indifference point AUC0.81.97.8-0.40.2-1.0-1.71.1-1.11.31.1-1.11.4-1.1-1.8-2.8
Delay disc. indifference point, 0s delay0.10.10.60.20.00.10.20.5-0.5-0.20.4-0.4-0.2-0.20.20.8
Delay disc. indifference point, 16s delay2.13.07.51.82.10.90.42.7-2.70.22.7-2.70.3-0.1-0.4-0.9
Delay disc. indifference point, 2s delay0.40.41.11.00.90.60.30.9-0.9-0.60.8-0.8-0.50.10.20.1
Delay disc. indifference point, 24s delay3.04.712.72.02.20.60.13.6-3.60.53.5-3.50.7-0.6-0.8-1.0
Delay disc. indifference point, 4s delay2.52.65.92.42.41.81.41.9-1.9-1.11.8-1.8-1.11.00.70.1
Delay disc. indifference point, 8s delay2.64.39.03.02.81.81.42.9-2.9-0.92.8-2.8-0.80.60.40.1
Indifference point function ln k0.51.43.80.90.41.21.6-0.80.8-1.2-0.70.7-1.31.21.62.0
Indifference point function log k0.51.43.80.90.41.21.6-0.80.8-1.2-0.70.7-1.31.21.62.0
Patch foraging total patch changes 0 sec0.41.22.70.50.31.11.2-1.01.0-1.1-1.01.0-1.31.01.51.6
Patch foraging total patch changes 12 sec0.10.10.30.00.50.30.10.4-0.4-0.10.2-0.2-0.10.10.0-0.2
Patch foraging total patch changes 18 sec0.20.51.3-0.7-0.2-0.7-1.00.2-0.20.80.2-0.20.7-0.8-1.0-1.2
Patch foraging total patch changes 24 sec0.00.10.20.20.40.4-0.00.2-0.2-0.2-0.00.0-0.40.40.2-0.4
Patch foraging total patch changes 6 sec0.00.00.10.00.20.20.2-0.00.0-0.00.0-0.0-0.20.20.20.1
Patch foraging time to switch 0 sec0.10.20.7-0.4-0.5-0.4-0.10.4-0.40.40.5-0.50.3-0.6-0.10.8
Patch foraging water rate 0 sec0.20.71.71.01.21.31.0-0.20.2-1.0-0.30.3-1.01.20.90.2
Patch foraging water rate 12 sec0.10.41.10.60.50.91.1-0.20.2-0.5-0.60.6-0.60.80.70.7
Patch foraging water rate 18 sec1.22.66.82.62.22.21.80.9-0.9-1.70.8-0.8-1.81.81.30.1
Patch foraging water rate 24 sec0.10.20.30.30.3-0.0-0.10.6-0.60.40.4-0.40.4-0.3-0.5-0.5
Patch foraging water rate 6 sec0.60.91.81.21.11.31.0-0.20.2-1.1-0.30.3-1.21.30.9-0.1
Seeking ratio, delayed vs. immediate footshock0.40.53.7-0.4-0.50.20.8-0.60.6-0.4-0.40.4-0.40.10.71.9
Distance traveled before self-admin0.20.41.10.0-0.10.2-0.2-1.11.1-0.5-0.70.7-0.40.70.3-0.7
Distance traveled after self-admin0.20.41.40.90.80.5-0.10.5-0.5-0.40.9-0.9-0.30.5-0.0-1.2
Extensor digitorum longus weight3.614.237.56.15.74.93.82.8-2.8-3.52.8-2.8-3.53.62.5-0.5
Bone: elastic displacement0.10.10.3-0.5-0.5-0.2-0.1-0.30.30.1-0.30.30.1-0.1-0.00.2
Bone: elastic work0.30.40.80.70.60.90.70.3-0.3-0.80.4-0.4-0.80.80.80.4
Bone: endosteal estimation0.10.10.4-0.5-0.5-0.4-0.6-0.30.30.0-0.20.20.10.0-0.2-0.6
Bone: endosteal perimeter0.20.41.4-1.0-1.2-0.7-0.8-0.70.70.2-0.60.60.2-0.1-0.2-0.3
Epididymis fat weight0.10.51.20.50.40.00.21.1-1.10.60.9-0.90.5-0.6-0.40.3
Delta time in closed arm before/after self-admin0.30.31.1-1.0-0.8-0.6-0.1-0.40.40.5-0.30.30.6-0.5-0.00.8
Delta time in open arm before/after self-admin0.20.20.50.70.50.50.50.4-0.4-0.70.2-0.2-0.60.30.40.3
Diff in mean of infusions in LGA sessions2.85.09.92.92.32.93.10.6-0.6-2.60.7-0.7-2.52.32.52.6
Delay discount exponential model param3.85.210.7-3.1-3.1-1.8-1.3-3.33.30.9-3.23.20.8-0.5-0.20.3
Extinction: sum of active levers before priming0.10.10.20.20.40.40.4-0.10.1-0.40.2-0.2-0.30.40.50.4
Active lever presses in extinction session 60.70.71.5-0.5-0.3-0.9-1.00.4-0.41.20.5-0.51.2-0.9-1.0-1.0
Bone: final force0.71.22.81.01.40.80.41.7-1.7-0.21.7-1.7-0.20.20.0-0.5
Bone: final moment0.50.81.71.01.30.90.51.2-1.2-0.51.2-1.2-0.50.50.3-0.4
Food consumed during 24 hour testing period0.10.20.40.20.00.40.2-0.50.5-0.6-0.70.7-0.70.60.5-0.1
Glucose0.61.02.00.70.8-0.2-0.61.3-1.30.71.2-1.20.8-0.7-1.0-1.4
Heart weight0.00.10.30.1-0.5-0.2-0.0-0.20.20.1-0.30.30.2-0.20.00.6
Delay discount hyperbolic model param3.44.38.7-2.9-2.8-1.7-1.2-3.03.00.9-2.92.90.8-0.5-0.30.2
Intermittent access intake day 1-15 change0.21.12.1-1.4-1.4-1.4-1.3-0.60.61.1-0.50.51.1-1.2-0.9-0.5
Intermittent access intake escalation0.10.51.1-1.0-1.1-0.9-0.8-0.50.50.8-0.40.40.8-0.7-0.6-0.2
Intermittent access intake escalation 20.10.20.5-0.5-0.7-0.6-0.4-0.30.30.4-0.10.10.4-0.5-0.4-0.0
Intermitt. access day 1 inactive lever presses0.11.74.1-1.6-1.5-0.60.4-1.61.60.5-1.91.90.4-0.30.52.0
Intermitt. access day 15 inactive lever presses0.31.73.9-0.5-0.50.61.0-2.02.0-1.0-1.71.7-0.71.21.31.3
Intermitt. access escalation Index0.00.10.5-0.2-0.5-0.5-0.40.2-0.20.40.1-0.10.2-0.7-0.40.2
Intermittent access day 1 total infusions0.30.82.2-0.9-0.5-1.1-1.40.0-0.01.0-0.20.20.9-1.0-1.2-1.5
Intermittent access day 15 total infusions0.71.73.2-1.7-1.5-1.8-1.8-0.50.51.5-0.40.41.4-1.6-1.4-1.0
Intermittent access terminal intake (last 3 days)1.22.14.2-1.6-1.5-1.9-2.1-0.40.41.6-0.20.21.6-1.6-1.8-1.7
Intermittent access total infusions2.42.95.3-2.1-1.6-2.3-2.3-0.20.22.1-0.10.12.1-2.0-2.0-1.6
Intermittent access day 1 locomotion0.10.10.30.30.40.30.30.3-0.3-0.20.2-0.2-0.40.10.30.5
Intermittent access day 15 total locomotion0.10.40.9-0.6-0.6-0.9-0.9-0.10.10.6-0.10.10.7-0.9-0.9-0.7
Intermittent access total locomotion0.10.10.4-0.4-0.4-0.5-0.3-0.10.10.3-0.00.00.2-0.6-0.40.0
Intermittent access standard deviation0.21.34.4-0.9-0.8-1.3-1.6-0.20.21.20.3-0.31.2-1.1-1.6-2.1
Left kidney weight0.43.26.11.71.22.12.1-1.01.0-2.5-0.90.9-2.42.32.31.6
Right kidney weight1.17.613.51.61.43.03.4-1.91.9-3.5-1.71.7-3.63.33.73.3
Cocaine induced anxiety0.41.22.71.41.01.41.60.6-0.6-1.10.3-0.3-1.11.01.21.5
Post-drug Anxiety1.92.14.81.20.51.51.8-0.90.9-1.6-1.11.1-1.61.71.92.2
Baseline Anxiety0.10.20.7-0.1-0.10.0-0.2-0.90.9-0.4-0.70.7-0.40.30.4-0.1
Tail length0.31.84.1-0.8-0.90.30.4-2.02.0-1.1-2.02.0-0.91.11.20.9
Length with tail0.62.64.90.70.41.61.8-1.21.2-2.0-1.21.2-2.12.02.22.0
Length without tail0.73.97.42.52.32.72.60.4-0.4-2.40.4-0.4-2.62.22.21.6
Times rat made contact with spout0.10.20.4-0.1-0.2-0.4-0.50.6-0.60.40.3-0.30.4-0.4-0.4-0.5
Lifetime Intake2.22.75.3-2.0-1.6-2.2-2.3-0.30.32.0-0.20.22.0-1.9-2.0-1.7
Liver weight, left1.72.95.21.41.02.02.2-1.21.2-2.1-1.01.0-2.32.02.01.8
Liver weight, right0.81.44.02.01.91.40.80.9-0.9-1.01.0-1.0-1.10.90.5-0.7
Locomotor activity2.84.48.32.11.72.82.9-0.60.6-2.6-0.50.5-2.72.62.62.1
Locomotor testing distance0.81.95.00.0-0.31.01.5-1.51.5-1.2-1.41.4-1.31.41.82.2
Locomotor testing rearing1.55.310.3-0.8-1.11.01.5-3.23.2-1.9-3.03.0-2.02.02.42.8
Locomotion in novel chamber0.30.40.80.70.70.70.50.3-0.3-0.90.3-0.3-0.50.80.80.3
Locomotion in novel chamber post-restriction0.41.12.50.20.8-0.1-0.61.6-1.60.51.4-1.40.6-0.6-1.0-1.5
Fecal boli incidents, locomotor time 10.20.62.40.80.5-0.1-0.70.7-0.7-0.20.8-0.8-0.2-0.6-0.9-1.5
Change in fecal boli incidents, locomotor task0.91.02.3-0.3-0.40.40.9-1.21.2-0.3-1.51.5-0.40.60.91.5
Time >=10cm from walls, locomotor time 11.11.32.9-0.1-0.30.81.2-1.31.3-1.1-1.21.2-1.11.21.51.7
Bouts of movement, locomotor time 10.30.40.90.2-0.0-0.5-0.50.7-0.70.30.9-0.90.5-0.9-0.9-0.7
Total resting periods, locomotor time 11.11.32.4-0.1-0.1-0.9-1.01.1-1.11.01.3-1.31.1-1.5-1.5-1.3
Rest time, locomotor task time 10.91.53.4-0.40.0-1.0-1.41.1-1.11.21.3-1.31.3-1.3-1.6-1.8
Distance moved, locomotor task time 10.20.51.0-0.3-0.40.20.5-0.70.7-0.2-1.01.0-0.30.90.81.0
Vertical activity count, locomotor time 10.21.22.70.40.41.21.1-1.01.0-1.3-1.21.2-1.31.71.40.7
Time >=10cm from walls, locomotor time 20.30.92.2-0.5-0.40.40.5-1.51.5-0.6-1.21.2-0.61.21.00.6
Bouts of movement, locomotor time 20.51.74.01.71.60.80.71.9-1.9-0.32.0-2.0-0.3-0.2-0.1-0.2
Total resting periods, locomotor time 20.52.04.51.91.80.90.62.1-2.1-0.42.1-2.1-0.3-0.2-0.2-0.5
Rest time, locomotor task time 22.33.88.41.51.8-0.0-0.92.8-2.80.62.7-2.70.6-1.0-1.7-2.9
Distance moved, locomotor task time 20.81.02.1-1.0-1.0-0.10.3-1.41.4-0.1-1.51.5-0.20.80.91.2
Vertical activity count, locomotor time 20.20.51.3-0.3-0.20.40.2-0.90.9-0.4-0.90.9-0.61.10.80.3
Light reinforcement 10.00.10.1-0.2-0.1-0.2-0.10.4-0.40.20.3-0.30.3-0.00.00.2
Light reinforcement 20.30.61.1-0.6-0.5-0.9-1.00.4-0.40.90.6-0.61.0-0.7-0.9-1.0
Bone: marrow area0.10.20.6-0.6-0.6-0.5-0.8-0.20.20.1-0.10.10.2-0.1-0.3-0.7
Bone: maximum diameter0.91.84.60.90.9-0.0-0.62.0-2.00.62.1-2.10.6-0.6-0.9-1.5
Bone: maximum force1.12.15.41.51.80.90.22.1-2.1-0.22.3-2.3-0.20.2-0.2-1.2
Bone: maximum moment0.81.53.31.41.71.10.41.6-1.6-0.61.8-1.8-0.60.50.2-0.9
Mean time between licks in bursts0.53.06.4-2.3-2.5-1.4-1.0-2.52.50.2-2.42.40.3-0.20.10.9
Mean num. licks in bursts0.10.40.7-0.7-0.8-0.6-0.8-0.60.60.3-0.70.70.1-0.3-0.4-0.7
Cd content in liver1.82.03.70.80.31.31.4-1.31.3-1.9-1.11.1-1.91.91.71.1
Co content in liver0.81.02.11.31.30.60.21.4-1.4-0.01.4-1.40.0-0.1-0.4-1.0
Cu content in liver0.30.40.91.00.80.70.60.7-0.7-0.60.7-0.7-0.50.60.40.0
Fe content in liver0.81.02.2-1.2-1.4-0.60.1-1.31.30.1-1.11.10.1-0.20.31.5
K content in liver0.20.20.8-0.9-0.7-0.7-0.4-0.10.10.4-0.10.10.5-0.5-0.30.2
Mg content in liver0.91.02.5-1.3-1.6-1.4-1.4-0.50.50.8-0.50.50.9-0.9-0.8-0.5
Mn content in liver0.80.92.0-1.4-1.2-1.2-1.3-0.50.50.9-0.40.41.1-1.0-0.8-0.5
Na content in liver3.74.28.52.72.52.92.80.2-0.2-2.50.2-0.2-2.52.52.31.4
Rb content in liver0.81.02.5-0.9-1.2-0.40.1-1.41.4-0.3-1.61.6-0.30.30.40.8
Se content in liver1.21.54.2-0.5-0.60.41.0-1.61.6-0.6-1.71.7-0.60.61.12.1
Sr content in liver0.70.61.4-0.9-1.1-0.20.1-1.21.2-0.6-0.70.7-0.50.60.60.9
Zn content in liver0.30.41.3-0.9-1.1-0.5-0.4-0.80.8-0.1-0.60.6-0.10.10.10.3
Bone: minimum diameter0.30.61.80.80.80.30.01.2-1.20.21.3-1.30.2-0.2-0.4-0.7
Time in familiar zone, hab. session 10.80.91.7-0.5-0.3-0.9-1.00.9-0.91.20.9-0.91.3-1.2-1.2-0.9
Time in novel zone, hab. session 10.80.92.51.61.31.31.10.4-0.4-1.10.4-0.4-1.11.10.80.2
Total zone transitions, hab. session 10.40.61.20.71.00.3-0.11.1-1.10.21.1-1.10.1-0.1-0.4-0.8
Total locomotion distance, hab. session 10.30.40.80.10.3-0.2-0.50.9-0.90.50.8-0.80.5-0.4-0.5-0.7
Locomotion velocity, hab. session 10.00.10.2-0.10.20.1-0.20.4-0.40.10.3-0.30.00.0-0.0-0.2
Time in familiar zone, hab. session 20.20.20.3-0.5-0.4-0.6-0.60.3-0.30.50.1-0.10.6-0.4-0.5-0.5
Time in novel zone, hab. session 20.00.00.10.40.30.10.00.3-0.30.10.3-0.3-0.0-0.1-0.0-0.1
Total zone transitions, hab. session 20.20.20.60.80.70.70.40.3-0.3-0.50.1-0.1-0.70.60.4-0.2
Total locomotion distance, hab. session 20.10.10.30.30.40.1-0.10.5-0.50.20.5-0.50.0-0.0-0.2-0.3
Locomotion velocity, hab. session 20.20.20.50.50.70.40.10.7-0.7-0.00.6-0.6-0.20.2-0.0-0.4
Novel to familiar place preference ratio0.40.51.0-0.6-0.4-0.8-0.90.3-0.31.00.4-0.41.0-0.9-1.0-0.8
Novelty place preference0.30.40.7-0.6-0.5-0.7-0.80.1-0.10.80.2-0.20.8-0.8-0.8-0.5
Time in novel zone, NPP test0.10.20.4-0.5-0.4-0.5-0.50.0-0.00.60.1-0.10.6-0.5-0.5-0.4
Total zone transitions, NPP test0.00.00.0-0.00.0-0.0-0.20.0-0.00.10.1-0.1-0.0-0.1-0.00.0
Total locomotion distance, NPP test0.70.92.7-1.6-1.5-1.1-1.0-0.90.90.8-0.80.80.6-0.7-0.30.3
Locomotion velocity, NPP test0.71.02.8-1.7-1.4-1.3-1.3-0.80.80.9-0.70.70.7-0.8-0.5-0.1
Intraocular pressure1.22.04.7-1.9-2.2-1.4-0.9-1.81.80.6-1.81.80.6-0.7-0.30.6
Delta distance traveled before/after self-admin0.70.81.81.11.10.70.51.3-1.3-0.31.2-1.2-0.20.20.1-0.2
Delta ambulatory time before/after self-admin0.50.92.21.01.00.40.11.5-1.50.11.4-1.40.1-0.2-0.3-0.6
Parametrial fat weight1.12.65.1-2.1-2.0-2.2-2.1-0.10.11.9-0.10.11.9-2.1-1.7-0.8
Pavlov. Cond. lever latency0.50.61.3-1.0-1.1-1.1-1.1-0.30.30.6-0.40.40.8-0.6-0.7-0.8
Pavlov. Cond. magazine entry latency0.50.71.70.50.51.01.3-0.70.7-0.8-0.40.4-0.90.81.01.3
Pavlov. Cond. change in total contacts1.31.44.01.82.01.71.30.6-0.6-1.00.9-0.9-1.11.00.80.0
Pavlov. Cond. index score1.72.14.81.71.82.12.20.0-0.0-1.50.3-0.3-1.71.51.61.5
Pavlov. Cond. latency score1.21.53.61.41.51.71.90.0-0.0-1.20.2-0.2-1.41.21.31.3
Pavlov. Cond. lever contacts0.70.82.01.11.21.31.40.2-0.2-0.70.3-0.3-0.90.80.91.1
Pavlov. Cond. magazine entry number1.31.63.6-1.5-1.6-1.8-1.90.2-0.21.4-0.10.11.5-1.4-1.4-1.1
Pavlov. Cond. intertrial magazine entries0.10.20.30.0-0.10.30.3-0.40.4-0.4-0.50.5-0.40.40.60.6
Pavlov. Cond. lever-magazine prob. diff.1.92.35.11.82.02.22.30.1-0.1-1.60.4-0.4-1.71.61.61.4
Pavlov. Cond. response bias1.11.43.11.51.61.71.80.1-0.1-1.20.3-0.3-1.31.21.11.0
Pavlov. Cond. lever latency1.52.13.9-1.1-0.7-1.6-1.31.3-1.32.01.2-1.21.8-2.0-1.6-0.6
Pavlov. Cond. magazine entry latency0.81.12.21.31.41.51.40.5-0.5-1.10.5-0.5-0.91.11.10.8
Pavlov. Cond. change in total contacts1.43.46.32.01.82.42.2-0.90.9-2.5-0.90.9-2.42.52.10.8
Pavlov. Cond. index score1.52.44.31.61.42.12.0-0.70.7-2.1-0.70.7-1.82.01.91.1
Pavlov. Cond. latency score1.72.74.71.51.32.12.1-0.90.9-2.2-0.90.9-1.92.12.01.4
Pavlov. Cond. lever contacts1.32.03.91.10.81.51.3-1.31.3-2.0-1.21.2-1.72.01.60.5
Pavlov. Cond. magazine entry number0.30.40.9-0.8-0.9-0.8-0.7-0.50.50.5-0.50.50.3-0.5-0.5-0.3
Pavlov. Cond. intertrial magazine entries2.45.113.1-3.5-3.6-3.1-2.6-1.71.72.1-1.61.61.8-2.1-1.5-0.2
Pavlov. Cond. lever-magazine prob. diff.1.42.14.11.61.62.01.9-0.40.4-1.9-0.40.4-1.71.91.70.9
Pavlov. Cond. response bias1.21.73.31.51.31.71.5-0.70.7-1.8-0.50.5-1.61.81.60.6
Time in closed arm before self-admin0.91.53.01.21.01.41.5-0.70.7-1.5-0.80.8-1.71.31.41.2
Time in closed arm after self-admin0.30.42.0-0.10.00.40.8-0.50.5-0.4-0.50.5-0.40.20.71.4
Time in open arm before self-admin0.40.51.1-1.0-0.8-0.8-0.90.1-0.10.80.2-0.20.9-0.5-0.6-0.7
Time in open arm after self-admin0.10.10.3-0.0-0.20.20.1-0.30.3-0.5-0.40.4-0.50.50.50.2
Bone: periosteal estimation0.20.61.70.20.4-0.1-0.51.1-1.10.31.3-1.30.3-0.2-0.5-1.0
Bone: periosteal perimeter0.10.20.6-0.1-0.0-0.1-0.30.7-0.70.30.7-0.70.3-0.2-0.3-0.4
Bone: post-yield work5.49.316.10.30.8-1.7-2.73.8-3.82.74.0-4.02.8-2.7-3.3-4.0
Progressive ratio test 1 active lever presses0.91.64.7-0.9-0.5-1.4-1.90.5-0.51.50.3-0.31.4-1.4-1.7-2.2
Progressive ratio test 1 breakpoint0.91.54.5-0.7-0.3-1.3-1.70.6-0.61.50.4-0.41.4-1.3-1.7-2.1
Progressive ratio test 1 inactive lever presses0.41.12.5-1.4-1.2-0.7-0.4-1.61.60.4-1.51.50.2-0.10.20.7
Progressive ratio test 2 active lever presses0.70.91.6-1.0-1.1-1.1-1.3-1.01.00.7-0.90.90.6-0.7-0.9-1.1
Progressive ratio test 2 breakpoint0.60.71.2-0.8-0.9-0.9-1.1-1.11.10.5-0.90.90.4-0.5-0.7-1.0
Progressive ratio test 2 inactive lever presses0.72.34.4-2.0-1.9-1.4-1.1-2.12.10.9-2.12.10.8-0.7-0.5-0.1
Incentive Sensitization - Responses0.51.34.2-0.6-1.0-0.1-0.0-2.12.1-0.8-1.71.7-0.80.40.50.3
Incentive Sensitization - Breakpoint0.71.54.7-0.6-1.0-0.1-0.0-2.22.2-0.8-1.81.8-0.80.50.60.3
Sum of active levers in priming session hrs 5-60.10.10.1-0.2-0.0-0.2-0.20.2-0.20.40.3-0.30.4-0.2-0.10.1
Progressive ratio0.41.33.71.21.11.51.2-0.30.3-1.9-0.10.1-1.71.41.30.4
Food seeking constrained by brief footshock0.40.50.9-0.6-0.2-0.8-0.70.6-0.60.90.7-0.70.9-0.9-0.9-0.7
Seeking ratio, punishment vs. effort0.51.23.2-0.7-0.5-1.2-0.90.9-0.91.80.7-0.71.6-1.3-1.3-0.6
Retroperitoneal fat weight0.20.81.8-1.1-1.0-1.2-1.10.3-0.31.10.1-0.11.2-1.3-0.9-0.1
Reaction time number correct0.10.40.9-0.6-0.9-0.6-0.5-0.80.80.2-0.80.80.1-0.2-0.2-0.1
Reaction time mean minus median0.21.12.10.80.61.21.4-0.90.9-1.2-0.70.7-1.31.01.31.4
Reaction time mean minus median AUC0.21.22.20.30.20.91.2-1.21.2-1.2-1.01.0-1.30.91.31.5
Reaction time num false alarms0.71.22.91.00.81.31.1-0.20.2-1.60.2-0.2-1.71.61.60.9
Reaction time num false alarms AUC0.51.02.31.20.91.31.00.1-0.1-1.50.4-0.4-1.51.41.30.5
Reaction time trials correct on left0.10.40.9-0.6-0.9-0.6-0.5-0.80.80.2-0.80.80.1-0.2-0.2-0.1
Reaction time trials on left0.10.51.2-0.7-1.1-0.7-0.6-0.90.90.2-0.90.90.1-0.3-0.2-0.1
Reaction time mean0.40.82.30.0-0.30.40.5-1.51.5-0.8-1.21.2-0.80.80.70.4
Reaction time mean AUC0.51.33.20.2-0.10.70.8-1.81.8-1.2-1.41.4-1.31.11.10.6
Median of all reaction times0.50.72.4-0.2-0.50.10.2-1.51.5-0.6-1.31.3-0.60.60.50.1
Reaction time omissions1.22.04.6-1.9-2.1-1.3-0.9-2.12.10.2-1.71.70.1-0.4-0.10.4
Reaction time false alarm rate0.81.11.91.31.31.41.10.5-0.5-1.20.8-0.8-1.31.21.10.5
Reaction time premature initiation rate0.30.41.10.80.90.50.61.0-1.00.10.8-0.80.10.0-0.1-0.1
Reaction time premature initiations0.10.20.40.30.3-0.00.00.6-0.60.40.5-0.50.3-0.3-0.4-0.4
Std. dev. reaction times0.10.40.90.1-0.00.40.5-1.01.0-0.5-0.80.8-0.50.40.50.5
Reaction time trials completed0.10.51.2-0.7-1.1-0.7-0.6-0.90.90.2-0.90.90.1-0.3-0.2-0.1
Reaction time trials AUC0.20.61.4-0.8-1.2-0.8-0.7-1.01.00.3-1.01.00.2-0.3-0.2-0.1
Run reversals in cocaine runway, females0.40.51.2-0.9-0.3-0.6-0.90.0-0.01.00.4-0.41.1-0.2-0.6-1.1
Run reversals in cocaine runway, males1.71.95.02.22.21.50.91.5-1.5-1.01.2-1.2-1.11.00.3-1.0
Latency to leave start box in cocaine runway1.01.42.4-1.5-1.5-1.4-1.3-1.01.00.8-1.11.11.0-1.2-1.1-0.9
Latency to leave start box in cocaine runway, F0.20.20.5-0.5-0.6-0.5-0.3-0.70.7-0.2-0.60.60.1-0.4-0.4-0.3
Latency to leave start box in cocaine runway, M1.31.32.3-1.4-1.5-1.1-1.1-1.41.40.6-1.51.50.7-0.5-0.5-0.5
Std. dev. time between licks in bursts0.91.84.3-1.7-1.7-0.7-0.3-2.12.10.0-1.81.80.1-0.00.41.2
Total sessions with >9 infusions0.50.71.2-1.0-0.9-0.9-1.0-1.11.10.4-0.80.80.2-0.4-0.5-0.6
Short access day 1 total inactive lever presses0.40.73.5-0.2-0.1-0.8-1.20.3-0.30.70.3-0.30.4-1.1-1.3-1.9
Short access day 10 total inactive lever presses0.10.40.8-0.9-0.8-0.8-0.7-0.40.40.6-0.30.30.5-0.8-0.6-0.2
Short access day 1 total infusions1.42.75.9-1.8-1.7-2.2-2.4-0.50.51.7-0.20.21.6-1.9-2.1-2.0
Short access day 10 total infusions0.20.42.0-0.40.1-0.5-0.90.2-0.20.70.2-0.20.6-0.5-0.9-1.4
Short access total infusions0.71.02.4-1.0-0.8-1.3-1.5-0.20.21.10.0-0.00.9-1.1-1.4-1.5
Short access day 1 locomotion0.10.20.70.0-0.10.1-0.1-0.90.9-0.6-0.40.4-0.80.30.3-0.2
Short access day 10 total locomotion0.10.51.20.40.00.50.7-0.60.6-1.0-0.40.4-1.10.40.91.1
Short access total locomotion0.30.41.30.40.20.60.5-0.80.8-0.9-0.40.4-1.10.60.70.4
One hour access (0.3 mA shock)1.51.73.3-1.0-0.6-1.5-1.80.6-0.61.70.7-0.71.6-1.7-1.7-1.5
Compulsive drug intake0.10.10.7-0.2-0.1-0.10.10.1-0.10.00.3-0.30.3-0.10.40.9
One hour access (shock baseline)0.61.63.4-1.3-1.1-1.6-1.9-0.10.11.5-0.00.01.3-1.6-1.7-1.7
Social response proportion1.31.63.5-1.6-1.9-1.7-1.2-1.01.01.3-1.01.01.2-1.4-1.1-0.1
Social responses1.92.55.9-2.2-2.4-2.0-1.3-1.11.11.9-1.21.21.7-1.8-1.10.7
Social time1.93.07.0-0.4-0.80.60.8-2.72.7-1.4-2.42.4-1.51.51.71.5
Soleus weight0.30.92.41.31.20.50.31.3-1.30.11.5-1.50.0-0.1-0.2-0.5
Bone: stiffness0.50.92.41.31.51.10.81.0-1.0-0.71.2-1.2-0.70.70.4-0.2
Tibialis anterior weight3.712.729.95.55.34.94.02.0-2.0-3.82.0-2.0-3.73.83.00.3
Time to tail flick, vehicle, before self-admin0.50.61.50.71.21.11.20.5-0.5-0.30.4-0.4-0.50.90.80.9
Time to tail flick, vehicle, after self-admin0.30.61.71.21.30.90.90.8-0.8-0.30.8-0.8-0.40.80.3-0.2
Time to tail flick, test, before self-admin0.20.20.5-0.2-0.10.20.1-0.70.7-0.4-0.70.7-0.60.50.50.3
Time to tail flick, test, after self-admin3.03.26.6-2.6-2.5-2.2-1.8-1.81.81.5-1.71.71.5-1.4-1.1-0.3
Delta time to tail flick, vehicle, before/after SA0.40.41.5-0.4-0.6-0.8-0.9-0.30.30.6-0.20.20.6-0.4-0.8-1.2
Delta time to tail flick, test, before/after SA1.92.34.6-2.2-2.1-2.0-1.5-1.11.11.6-1.21.21.7-1.4-1.2-0.5
Tibia length2.87.713.20.30.62.63.0-2.52.5-3.3-2.72.7-3.23.33.63.5
Ambulatory time before self-admin0.00.21.00.1-0.0-0.0-0.4-0.50.5-0.1-0.30.30.00.3-0.2-1.0
Ambulatory time after self-admin0.61.02.51.61.41.00.30.9-0.9-0.71.2-1.2-0.60.70.1-1.2
Bone: tissue strength0.20.30.6-0.2-0.5-0.3-0.7-0.80.8-0.3-0.50.5-0.30.2-0.0-0.7
Total heroin consumption0.60.71.71.31.20.80.40.9-0.9-0.71.0-1.0-0.60.40.1-0.7
Bone: trabecular number0.61.23.3-1.8-1.7-0.9-0.5-1.41.40.1-1.31.30.2-0.10.30.8
Bone: trabecular spacing1.42.14.92.02.21.30.92.1-2.1-0.31.8-1.8-0.40.30.0-0.5
Bone: trabecular thickness0.10.20.30.40.60.50.20.4-0.4-0.30.6-0.6-0.30.40.30.0
Bone: trabecular tissue density1.42.45.22.22.32.22.20.7-0.7-1.40.7-0.7-1.51.41.31.1
Water consumed over 24 hours0.30.61.31.11.01.00.70.5-0.5-1.00.2-0.2-0.91.00.7-0.2
Number of responses in last shaping day0.60.71.61.21.30.70.31.1-1.1-0.61.1-1.1-0.70.0-0.2-0.7