Hub : Genes

Ints9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Ints9 0.1 0.07 4.1e-03 0.02 0.04 0.02 0.01 4.2e-02 1.1e-02 6.4e-02 6.8e-02
2 Adipose gene expression Ints9 0.1 0.09 2.6e-07 0.06 0.06 0.06 0.06 1.7e-07 1.4e-07 2.2e-07 3.6e-07
3 Brain mRNA stability Ints9 0.29 0.11 0.0e+00 0.26 0.27 0.28 0.26 1.0e-23 2.0e-25 2.4e-26 4.3e-24
4 Liver gene expression Ints9 0.13 0.07 4.5e-13 0.09 0.07 0.07 0.07 4.1e-10 5.1e-08 1.5e-08 1.1e-08
5 IL mRNA stability Ints9 0.26 0.17 3.6e-03 0.02 0.01 0.01 0.01 9.7e-02 1.8e-01 1.5e-01 1.9e-01
6 NAcc mRNA stability Ints9 0.04 0.03 1.3e-04 0.03 0.03 0.02 0.03 1.7e-04 5.7e-04 2.6e-03 2.0e-04
7 PL mRNA stability Ints9 0.05 0.03 1.4e-04 0.03 0.02 0.04 0.03 1.0e-04 1.4e-03 3.1e-05 3.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.10.21.2-0.31.10.50.10.00.0-0.1
Area under the delay curve1.41.57.31.3-2.7-0.80.3-0.5-0.30.8
BMI with tail0.41.24.61.2-2.1-1.10.6-0.6-0.60.3
BMI without tail0.30.61.0-0.80.51.0-0.70.80.81.0
Body weight1.45.98.92.9-2.5-3.02.2-2.3-2.3-1.3
Weight adjusted by age3.84.36.11.9-0.9-2.22.2-2.2-2.2-2.5
Bone surface0.10.10.4-0.10.70.40.10.00.0-0.1
Bone volume0.10.10.6-0.20.30.7-0.20.30.30.3
Breakpoint value in progressive ratio session0.20.30.60.4-0.8-0.2-0.50.50.50.6
Number of licking bursts0.10.10.40.3-0.6-0.3-0.10.00.00.5
Context. condit. distance diff. score3.94.75.8-2.21.22.0-2.32.42.42.4
Locomotion velocity, session 10.10.10.20.3-0.50.10.1-0.0-0.10.3
Locomotion distance, session 10.00.00.3-0.0-0.20.50.0-0.0-0.10.2
Locomotion velocity, session 20.10.10.50.2-0.70.2-0.30.20.30.6
Locomotion distance, session 20.00.00.20.00.10.50.1-0.1-0.1-0.1
Locomotion velocity, session 31.21.41.81.0-0.8-1.11.4-1.3-1.3-1.2
Locomotion distance, session 30.30.30.60.6-0.7-0.50.5-0.6-0.6-0.2
Stereotopy head waving bouts, day 30.60.82.20.50.5-0.80.9-0.8-0.9-1.5
Stereotopy head waving duration, day 31.72.13.31.2-0.8-1.31.6-1.5-1.6-1.8
Locomotion velocity, session 73.33.75.2-1.71.41.5-2.02.22.12.3
Locomotion distance, session 73.74.75.7-2.01.92.1-2.22.32.32.4
Stereotopy head waving bouts, day 71.82.02.31.4-1.4-1.31.5-1.4-1.5-1.3
Stereotopy head waving duration, day 73.84.65.22.0-1.7-2.22.3-2.2-2.3-2.2
Locomotion velocity, session 80.30.40.6-0.6-0.30.7-0.60.70.70.8
Locomotion distance, session 81.31.92.7-1.30.61.6-1.41.41.41.7
Degree of sensitization distance8.48.59.7-2.82.62.8-3.03.13.12.9
Degree of sensitization stereotypy0.91.01.91.0-1.4-1.01.0-0.9-1.0-0.7
Conditioned locomotion0.60.70.9-0.90.70.7-0.90.90.90.6
Cocaine response after cond. corrected1.21.42.3-1.1-0.01.0-1.31.31.31.5
Cocaine response after cond. not corrected0.80.92.1-0.7-0.20.8-1.01.01.01.4
Cocaine response before conditioning0.70.91.61.3-0.3-0.91.0-1.0-1.0-0.6
Saline control response0.10.10.20.4-0.1-0.20.3-0.4-0.4-0.2
Bone: connectivity density0.50.84.8-0.02.2-0.10.4-0.4-0.3-0.7
Bone: cortical apparent density0.00.00.1-0.1-0.3-0.0-0.10.10.10.3
Bone: cortical area0.40.62.5-0.0-1.60.4-0.50.50.51.0
Bone: cortical porosity2.02.12.91.7-1.6-1.61.3-1.4-1.4-1.0
Bone: cortical porosity1.31.42.11.3-1.5-1.31.0-1.1-1.1-0.8
Bone: cortical thickness0.50.84.60.5-2.1-0.2-0.20.20.20.9
Bone: cortical thickness3.03.58.3-1.0-1.51.4-2.01.91.92.9
Bone: cortical tissue density0.00.00.1-0.1-0.30.0-0.10.10.10.3
Condit. Reinf. active minus inactive responses0.50.60.80.8-0.5-0.90.7-0.7-0.7-0.8
Condit. Reinf. active-inactive response ratio0.10.10.50.00.2-0.30.3-0.3-0.3-0.7
Condit. Reinf. active responses0.50.61.11.1-0.7-0.90.6-0.7-0.7-0.6
Condit. Reinf. inactive responses0.30.31.21.1-0.4-0.70.4-0.4-0.5-0.1
Incentive salience index mean1.51.82.91.7-1.4-1.61.2-1.2-1.2-1.0
Condit. Reinf. lever presses1.62.14.12.0-1.8-1.61.2-1.2-1.1-0.5
Condit. Reinf. active minus inactive responses0.40.50.7-0.50.20.6-0.80.90.90.7
Condit. Reinf. active-inactive response ratio0.20.20.3-0.60.10.4-0.50.60.60.2
Condit. Reinf. active responses0.40.60.8-0.60.40.8-0.80.90.90.9
Condit. Reinf. inactive responses0.81.01.2-0.71.11.0-1.01.01.01.1
Condit. Reinf. lever presses0.50.60.90.7-0.0-0.61.0-0.9-0.9-0.9
Condit. Reinf. lever reinforcers received0.20.20.4-0.40.10.5-0.50.60.60.6
Conditioned reinforcement - actives6.86.810.1-3.22.83.1-2.42.42.41.5
Conditioned reinforcement - inactives0.70.73.2-0.41.80.7-0.40.80.70.2
Conditioned locomotion3.23.95.1-2.01.22.0-2.32.12.02.0
Patch foraging indifference point 0 sec0.50.91.81.3-0.2-1.00.9-0.9-0.9-0.9
Patch foraging indifference point AUC1.61.83.3-1.8-0.31.8-1.21.31.31.3
Delay disc. indifference point, 0s delay0.10.10.20.4-0.1-0.2-0.40.10.20.5
Delay disc. indifference point, 16s delay0.91.04.90.7-2.2-0.10.10.00.11.1
Delay disc. indifference point, 2s delay0.20.20.90.5-1.0-0.3-0.1-0.3-0.20.1
Delay disc. indifference point, 24s delay1.21.25.00.5-2.20.0-0.40.30.41.6
Delay disc. indifference point, 4s delay1.31.44.91.3-2.2-1.00.8-0.9-0.7-0.0
Delay disc. indifference point, 8s delay2.02.18.01.6-2.8-1.40.7-1.0-0.80.3
Indifference point function ln k1.41.93.11.8-0.6-1.71.4-1.3-1.3-1.3
Indifference point function log k1.41.93.11.8-0.6-1.71.4-1.3-1.3-1.3
Patch foraging total patch changes 0 sec0.71.22.41.5-0.5-1.21.1-1.1-1.0-0.9
Patch foraging total patch changes 12 sec0.00.10.30.2-0.50.10.0-0.1-0.10.3
Patch foraging total patch changes 18 sec0.70.91.7-1.00.31.3-1.00.90.91.0
Patch foraging total patch changes 24 sec0.10.10.20.3-0.40.00.4-0.3-0.4-0.3
Patch foraging total patch changes 6 sec0.00.00.10.2-0.2-0.10.1-0.1-0.10.0
Patch foraging time to switch 0 sec0.10.10.20.10.5-0.1-0.50.20.30.4
Patch foraging water rate 0 sec0.60.91.61.0-1.3-0.61.2-0.9-0.9-0.5
Patch foraging water rate 12 sec0.20.30.50.7-0.7-0.50.7-0.3-0.3-0.5
Patch foraging water rate 18 sec2.53.45.51.6-2.4-1.91.9-1.8-1.8-1.4
Patch foraging water rate 24 sec0.20.20.4-0.5-0.20.3-0.40.60.60.5
Patch foraging water rate 6 sec0.81.21.60.8-1.2-0.71.2-1.2-1.2-1.3
Seeking ratio, delayed vs. immediate footshock0.20.20.70.80.3-0.80.2-0.3-0.1-0.0
Distance traveled before self-admin0.10.10.7-0.40.20.80.3-0.10.00.3
Distance traveled after self-admin0.20.20.9-0.70.01.0-0.00.20.20.3
Extensor digitorum longus weight3.413.331.53.2-5.6-3.33.4-3.4-3.4-2.4
Bone: elastic displacement0.00.00.00.10.20.10.0-0.1-0.1-0.2
Bone: elastic work0.50.71.01.0-0.9-0.50.9-0.9-0.9-0.8
Bone: endosteal estimation0.00.10.2-0.30.30.4-0.20.20.2-0.0
Bone: endosteal perimeter0.20.30.8-0.60.90.8-0.40.40.4-0.0
Epididymis fat weight0.20.41.20.20.00.0-0.60.80.61.1
Delta time in closed arm before/after self-admin0.20.20.8-0.20.90.2-0.20.40.40.4
Delta time in open arm before/after self-admin0.00.00.1-0.00.2-0.2-0.30.10.10.1
Diff in mean of infusions in LGA sessions5.15.68.83.0-2.2-2.92.1-2.3-2.3-1.4
Delay discount exponential model param1.61.68.0-1.22.80.9-0.30.60.4-0.7
Extinction: sum of active levers before priming0.20.20.5-0.10.30.2-0.70.70.70.1
Active lever presses in extinction session 60.60.50.9-0.70.60.7-0.81.01.00.3
Bone: final force0.30.42.40.6-1.5-0.30.0-0.0-0.00.3
Bone: final moment0.30.52.20.7-1.5-0.50.3-0.4-0.4-0.2
Food consumed during 24 hour testing period0.20.30.70.1-0.1-0.20.6-0.6-0.6-0.8
Glucose0.40.61.0-0.9-0.40.7-0.90.80.71.0
Heart weight0.20.20.40.40.0-0.60.3-0.5-0.5-0.6
Delay discount hyperbolic model param1.71.88.2-1.42.91.0-0.50.80.6-0.5
Intermittent access intake day 1-15 change0.40.41.0-0.71.00.2-0.70.60.6-0.1
Intermittent access intake escalation0.60.61.0-1.00.90.5-1.00.80.80.1
Intermittent access intake escalation 20.20.10.5-0.40.7-0.0-0.30.30.3-0.3
Intermitt. access day 1 inactive lever presses0.40.42.10.21.4-0.5-0.20.40.4-0.2
Intermitt. access day 15 inactive lever presses1.71.83.71.10.5-1.31.5-1.3-1.4-1.9
Intermitt. access escalation Index1.61.42.0-1.30.51.3-1.41.21.21.2
Intermittent access day 1 total infusions1.41.73.0-1.70.31.7-1.31.21.11.2
Intermittent access day 15 total infusions2.73.04.6-2.21.31.8-2.11.71.71.1
Intermittent access terminal intake (last 3 days)2.52.75.4-2.31.01.8-1.91.61.60.9
Intermittent access total infusions3.94.36.0-2.41.22.3-2.32.12.11.8
Intermittent access day 1 locomotion0.20.20.8-0.1-0.30.7-0.40.30.30.9
Intermittent access day 15 total locomotion0.50.61.0-0.90.50.7-1.00.80.80.6
Intermittent access total locomotion0.20.20.5-0.30.00.4-0.70.40.40.6
Intermittent access standard deviation0.80.92.2-1.50.81.1-0.80.80.8-0.1
Left kidney weight2.05.77.22.2-1.4-2.72.4-2.5-2.5-2.6
Right kidney weight3.610.114.03.7-1.6-3.73.2-3.2-3.3-3.0
Cocaine induced anxiety0.40.50.90.9-0.4-0.60.9-0.6-0.7-0.7
Post-drug Anxiety1.92.13.92.0-0.0-1.41.9-1.3-1.4-1.3
Baseline Anxiety0.00.00.20.40.3-0.10.1-0.1-0.10.2
Tail length0.10.42.2-0.21.50.20.2-0.2-0.2-0.7
Length with tail1.13.95.52.1-0.6-2.31.9-2.1-2.1-2.1
Length without tail3.78.011.23.1-2.7-3.32.7-2.8-2.8-2.4
Times rat made contact with spout0.20.20.4-0.60.20.6-0.40.30.30.3
Lifetime Intake3.84.36.3-2.51.42.3-2.32.02.01.6
Liver weight, left1.72.83.81.3-1.9-1.91.6-1.6-1.6-1.6
Liver weight, right0.50.93.20.6-1.8-0.41.0-0.8-0.8-0.5
Locomotor activity4.26.77.92.8-2.0-2.72.6-2.7-2.7-2.4
Locomotor testing distance1.21.92.61.6-0.2-1.31.5-1.5-1.5-1.6
Locomotor testing rearing2.13.35.71.80.8-1.61.9-1.9-1.9-2.4
Locomotion in novel chamber0.60.81.10.9-0.9-0.80.9-1.1-1.0-0.5
Locomotion in novel chamber post-restriction0.20.30.6-0.6-0.70.6-0.50.30.40.6
Fecal boli incidents, locomotor time 10.20.20.7-0.9-0.6-0.0-0.4-0.2-0.2-0.5
Change in fecal boli incidents, locomotor task0.40.30.70.80.3-0.80.6-0.5-0.5-0.4
Time >=10cm from walls, locomotor time 11.11.11.71.00.3-1.01.2-1.1-1.1-1.3
Bouts of movement, locomotor time 10.20.20.7-0.8-0.00.4-0.80.20.30.2
Total resting periods, locomotor time 10.91.01.9-1.40.11.0-1.30.91.00.9
Rest time, locomotor task time 10.60.61.0-1.0-0.40.9-0.70.70.80.9
Distance moved, locomotor task time 10.10.10.40.30.6-0.10.20.0-0.0-0.2
Vertical activity count, locomotor time 10.70.81.20.9-0.3-0.41.1-1.0-1.0-1.1
Time >=10cm from walls, locomotor time 20.50.61.40.40.6-0.41.0-0.7-0.7-1.2
Bouts of movement, locomotor time 20.40.42.20.4-1.5-0.6-0.2-0.1-0.00.4
Total resting periods, locomotor time 20.50.53.00.3-1.7-0.6-0.2-0.1-0.00.4
Rest time, locomotor task time 20.80.92.9-1.0-1.70.6-0.60.50.61.0
Distance moved, locomotor task time 20.20.20.90.41.00.20.4-0.1-0.1-0.2
Vertical activity count, locomotor time 20.20.20.50.40.20.50.7-0.4-0.4-0.2
Light reinforcement 10.10.20.7-0.00.40.5-0.20.40.40.8
Light reinforcement 20.70.91.3-1.20.81.1-0.80.91.00.9
Bone: marrow area0.10.10.3-0.40.40.5-0.30.30.30.1
Bone: maximum diameter0.40.81.1-0.7-1.00.8-0.90.90.91.1
Bone: maximum force0.30.63.50.4-1.9-0.0-0.10.10.10.5
Bone: maximum moment0.30.53.20.6-1.8-0.20.2-0.3-0.30.0
Mean time between licks in bursts0.91.37.2-0.92.70.7-0.50.40.4-0.4
Mean num. licks in bursts0.30.30.7-0.80.80.8-0.20.30.3-0.2
Cd content in liver0.20.20.6-0.10.8-0.10.2-0.2-0.2-0.7
Co content in liver0.60.71.3-0.6-1.10.7-0.70.70.71.0
Cu content in liver0.30.30.40.4-0.5-0.60.6-0.5-0.5-0.6
Fe content in liver0.20.31.60.01.3-0.40.1-0.1-0.1-0.4
K content in liver0.70.71.0-0.60.50.7-0.91.01.01.0
Mg content in liver0.90.91.1-1.00.91.0-0.91.01.00.8
Mn content in liver1.61.82.4-1.01.11.4-1.41.41.41.6
Na content in liver7.17.59.33.1-2.5-2.82.9-2.8-2.8-2.3
Rb content in liver0.40.51.9-0.81.40.3-0.40.40.40.0
Se content in liver0.40.51.41.20.2-1.00.6-0.6-0.6-0.6
Sr content in liver0.40.42.3-0.51.50.40.0-0.0-0.0-0.2
Zn content in liver3.13.44.41.9-1.1-1.82.1-2.0-2.0-1.9
Bone: minimum diameter0.20.31.3-0.0-1.10.3-0.30.30.30.6
Time in familiar zone, hab. session 11.31.31.8-1.00.21.3-1.11.21.31.3
Time in novel zone, hab. session 11.21.21.51.0-1.2-1.21.0-1.1-1.1-0.9
Total zone transitions, hab. session 10.20.21.10.0-1.10.5-0.20.10.10.6
Total locomotion distance, hab. session 10.20.30.7-0.1-0.40.6-0.50.50.50.8
Locomotion velocity, hab. session 10.10.10.20.3-0.40.2-0.10.10.10.5
Time in familiar zone, hab. session 20.20.20.5-0.70.50.4-0.50.40.50.3
Time in novel zone, hab. session 20.00.00.10.1-0.30.2-0.00.1-0.00.2
Total zone transitions, hab. session 20.30.30.70.5-0.9-0.20.6-0.7-0.6-0.4
Total locomotion distance, hab. session 20.10.10.30.1-0.60.3-0.10.10.20.4
Locomotion velocity, hab. session 20.10.10.80.3-0.90.10.1-0.1-0.00.3
Novel to familiar place preference ratio0.80.81.0-0.80.30.9-1.01.01.01.0
Novelty place preference0.50.50.8-0.70.40.7-0.90.80.80.8
Time in novel zone, NPP test0.30.30.4-0.50.30.5-0.60.60.60.5
Total zone transitions, NPP test0.00.00.10.1-0.20.3-0.10.0-0.00.2
Total locomotion distance, NPP test0.50.71.7-0.51.31.0-0.80.70.70.6
Locomotion velocity, NPP test0.70.91.8-0.71.31.2-0.90.80.80.7
Intraocular pressure0.71.04.0-1.12.00.8-0.80.60.6-0.1
Delta distance traveled before/after self-admin0.00.10.3-0.0-0.5-0.10.0-0.2-0.2-0.1
Delta ambulatory time before/after self-admin0.10.10.2-0.4-0.50.2-0.40.20.2-0.0
Parametrial fat weight4.07.89.3-2.72.13.1-3.02.93.02.7
Pavlov. Cond. lever latency0.50.61.2-1.11.01.1-0.50.50.50.2
Pavlov. Cond. magazine entry latency0.91.22.51.4-0.7-1.61.0-1.0-1.0-0.7
Pavlov. Cond. change in total contacts1.41.54.01.4-2.0-1.31.0-1.0-1.0-0.5
Pavlov. Cond. index score2.43.05.02.2-1.8-2.21.6-1.6-1.5-0.9
Pavlov. Cond. latency score1.72.23.81.9-1.5-2.01.3-1.3-1.2-0.7
Pavlov. Cond. lever contacts1.41.73.01.6-1.2-1.71.2-1.2-1.1-0.7
Pavlov. Cond. magazine entry number1.72.13.4-1.71.41.8-1.41.41.41.0
Pavlov. Cond. intertrial magazine entries0.10.20.30.5-0.0-0.20.5-0.4-0.5-0.6
Pavlov. Cond. lever-magazine prob. diff.2.83.55.52.3-2.0-2.31.7-1.7-1.6-1.0
Pavlov. Cond. response bias2.42.94.82.0-1.7-2.21.6-1.6-1.5-1.1
Pavlov. Cond. lever latency2.53.34.2-1.71.01.8-2.02.02.02.0
Pavlov. Cond. magazine entry latency1.72.03.51.9-1.5-1.61.2-1.3-1.3-0.7
Pavlov. Cond. change in total contacts4.46.07.02.4-2.0-2.52.6-2.6-2.6-2.4
Pavlov. Cond. index score3.44.45.42.3-1.7-2.32.1-2.2-2.2-1.8
Pavlov. Cond. latency score3.74.65.82.4-1.5-2.42.2-2.3-2.3-1.9
Pavlov. Cond. lever contacts2.22.93.91.5-0.9-1.51.9-2.0-2.0-1.9
Pavlov. Cond. magazine entry number0.50.61.3-1.11.10.8-0.50.60.60.1
Pavlov. Cond. intertrial magazine entries4.86.313.5-2.63.72.6-2.22.22.21.4
Pavlov. Cond. lever-magazine prob. diff.3.24.15.02.2-1.7-2.22.0-2.1-2.1-1.7
Pavlov. Cond. response bias2.12.83.31.8-1.5-1.61.7-1.8-1.8-1.5
Time in closed arm before self-admin3.23.64.82.1-1.7-2.01.9-2.2-2.2-1.2
Time in closed arm after self-admin1.11.22.41.5-0.7-1.21.1-1.1-1.1-0.3
Time in open arm before self-admin1.11.22.7-1.41.01.7-0.81.01.00.6
Time in open arm after self-admin0.20.31.1-0.61.00.4-0.30.30.3-0.1
Bone: periosteal estimation0.20.30.4-0.4-0.50.6-0.60.60.60.6
Bone: periosteal perimeter0.10.20.3-0.3-0.20.5-0.50.60.50.5
Bone: post-yield work4.96.79.5-2.4-0.62.6-2.82.82.83.1
Progressive ratio test 1 active lever presses2.42.53.6-1.90.11.8-1.71.61.51.6
Progressive ratio test 1 breakpoint2.62.73.6-1.90.11.9-1.81.61.61.7
Progressive ratio test 1 inactive lever presses0.50.51.4-0.81.20.7-0.80.60.50.3
Progressive ratio test 2 active lever presses3.63.97.2-2.71.82.1-2.11.91.91.0
Progressive ratio test 2 breakpoint2.42.75.2-2.31.61.7-1.71.51.50.7
Progressive ratio test 2 inactive lever presses1.21.43.0-1.41.71.1-1.11.11.00.2
Incentive Sensitization - Responses1.01.03.6-1.41.90.5-0.80.40.4-0.7
Incentive Sensitization - Breakpoint1.01.03.8-1.42.00.5-0.70.30.3-0.8
Sum of active levers in priming session hrs 5-60.90.91.2-0.90.71.1-0.91.11.10.6
Progressive ratio2.02.33.91.2-1.0-1.31.6-2.0-1.8-1.6
Food seeking constrained by brief footshock0.50.61.1-0.70.30.6-0.70.90.91.0
Seeking ratio, punishment vs. effort1.31.62.8-1.00.51.0-1.31.71.51.5
Retroperitoneal fat weight1.13.55.2-1.71.01.5-2.32.02.12.2
Reaction time number correct0.20.30.9-0.71.00.5-0.20.30.2-0.1
Reaction time mean minus median1.31.72.41.5-0.8-1.51.2-1.4-1.4-1.2
Reaction time mean minus median AUC1.11.52.11.3-0.3-1.41.1-1.4-1.4-1.3
Reaction time num false alarms1.21.62.41.5-0.7-1.21.5-1.4-1.4-1.1
Reaction time num false alarms AUC0.91.31.81.2-0.8-1.01.3-1.2-1.2-1.0
Reaction time trials correct on left0.20.30.9-0.71.00.5-0.20.30.2-0.1
Reaction time trials on left0.20.31.2-0.71.10.5-0.30.30.3-0.1
Reaction time mean0.60.81.80.60.3-0.80.9-1.0-1.0-1.3
Reaction time mean AUC1.21.63.01.00.1-1.21.3-1.4-1.4-1.7
Median of all reaction times0.40.51.40.20.7-0.50.7-0.7-0.7-1.2
Reaction time omissions0.50.74.3-0.62.10.3-0.20.0-0.0-0.7
Reaction time false alarm rate0.91.21.81.4-1.2-1.11.2-1.1-1.0-0.6
Reaction time premature initiation rate0.10.20.80.4-0.9-0.50.10.10.10.3
Reaction time premature initiations0.00.10.1-0.2-0.2-0.0-0.20.30.40.3
Std. dev. reaction times0.30.40.60.5-0.1-0.70.6-0.7-0.7-0.8
Reaction time trials completed0.20.31.2-0.71.10.5-0.30.30.3-0.1
Reaction time trials AUC0.30.41.4-0.81.20.6-0.30.40.3-0.1
Run reversals in cocaine runway, females0.40.41.4-0.10.41.20.20.70.50.8
Run reversals in cocaine runway, males1.11.04.30.6-2.1-0.60.8-0.9-0.9-0.5
Latency to leave start box in cocaine runway0.70.71.7-1.31.10.7-0.80.60.7-0.2
Latency to leave start box in cocaine runway, F0.10.10.4-0.50.3-0.1-0.1-0.2-0.0-0.6
Latency to leave start box in cocaine runway, M0.50.52.4-0.71.50.4-0.10.30.3-0.5
Std. dev. time between licks in bursts0.30.32.10.11.50.1-0.00.10.1-0.3
Total sessions with >9 infusions0.70.82.2-1.11.50.7-1.00.60.60.1
Short access day 1 total inactive lever presses1.21.32.6-1.60.71.4-1.11.21.10.6
Short access day 10 total inactive lever presses0.40.41.0-0.41.00.3-0.70.80.70.5
Short access day 1 total infusions3.33.56.3-2.52.01.9-2.11.61.60.9
Short access day 10 total infusions1.31.52.6-1.3-0.41.6-1.21.21.11.4
Short access total infusions1.21.42.5-1.60.81.4-1.41.11.00.7
Short access day 1 locomotion0.20.20.70.10.5-0.10.3-0.5-0.4-0.9
Short access day 10 total locomotion0.91.12.01.4-0.5-1.21.0-1.1-1.1-0.6
Short access total locomotion0.60.61.11.0-0.1-0.80.8-0.9-0.9-0.7
One hour access (0.3 mA shock)2.73.24.1-2.00.71.9-2.01.91.91.6
Compulsive drug intake0.20.20.90.2-0.30.3-0.20.30.30.9
One hour access (shock baseline)2.42.75.0-2.21.11.8-1.91.61.60.9
Social response proportion2.02.13.5-1.81.91.1-1.61.41.40.7
Social responses2.02.54.9-1.32.21.1-1.71.71.71.1
Social time1.31.73.00.90.6-1.01.4-1.5-1.5-1.7
Soleus weight0.10.21.30.2-1.1-0.2-0.20.00.10.4
Bone: stiffness0.20.41.60.6-1.3-0.60.3-0.3-0.20.1
Tibialis anterior weight4.515.327.03.8-5.2-3.73.8-3.8-3.8-2.8
Time to tail flick, vehicle, before self-admin1.71.84.02.0-1.4-1.31.6-1.0-1.0-0.1
Time to tail flick, vehicle, after self-admin0.60.72.10.9-1.4-0.50.9-0.6-0.60.1
Time to tail flick, test, before self-admin0.60.61.20.5-0.3-0.00.9-0.9-0.9-1.1
Time to tail flick, test, after self-admin2.52.66.0-1.62.41.6-1.31.51.50.8
Delta time to tail flick, vehicle, before/after SA0.70.71.8-1.30.61.1-0.80.80.70.3
Delta time to tail flick, test, before/after SA3.83.45.4-1.82.31.6-1.51.92.01.6
Tibia length3.08.412.03.5-0.8-3.23.1-3.0-3.0-2.9
Ambulatory time before self-admin0.10.10.5-0.4-0.00.7-0.10.30.40.2
Ambulatory time after self-admin0.10.10.6-0.2-0.80.40.2-0.2-0.20.2
Bone: tissue strength0.20.20.6-0.30.60.30.3-0.2-0.3-0.8
Total heroin consumption0.20.30.70.3-0.9-0.40.4-0.5-0.5-0.4
Bone: trabecular number0.20.42.0-0.41.40.5-0.10.20.2-0.1
Bone: trabecular spacing0.60.84.00.8-2.0-0.60.3-0.3-0.40.3
Bone: trabecular thickness0.10.20.50.6-0.7-0.20.3-0.3-0.30.1
Bone: trabecular tissue density1.31.93.61.6-1.9-1.51.2-1.2-1.2-0.8
Water consumed over 24 hours0.81.01.30.8-1.1-0.71.1-1.1-1.1-1.0
Number of responses in last shaping day0.20.30.50.2-0.4-0.6-0.0-0.6-0.7-0.6