Hub : Genes

Krt81

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Krt81 0.04 0.03 1.1e-03 0.03 0.04 0.03 0.04 9.1e-04 5.1e-04 2.4e-03 5.0e-04
2 Adipose gene expression Krt81 0.03 0.02 7.2e-04 0.02 0.02 0.02 0.02 2.7e-03 1.2e-03 4.4e-03 2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.20.2-0.50.5
Area under the delay curve0.10.10.2-0.40.3
BMI with tail1.86.36.5-2.52.5
BMI without tail0.72.22.2-1.51.5
Body weight0.52.12.2-1.51.4
Weight adjusted by age1.32.02.4-1.31.5
Bone surface0.20.30.4-0.50.6
Bone volume0.40.70.7-0.80.9
Breakpoint value in progressive ratio session0.00.00.00.0-0.0
Number of licking bursts0.00.00.1-0.20.1
Context. condit. distance diff. score0.00.10.10.1-0.3
Locomotion velocity, session 13.94.24.82.2-1.9
Locomotion distance, session 10.50.60.80.9-0.6
Locomotion velocity, session 22.22.52.91.7-1.5
Locomotion distance, session 20.71.01.21.1-0.9
Locomotion velocity, session 35.05.76.12.5-2.3
Locomotion distance, session 35.25.75.92.4-2.3
Stereotopy head waving bouts, day 31.92.22.3-1.51.5
Stereotopy head waving duration, day 30.10.10.1-0.30.3
Locomotion velocity, session 71.31.41.61.1-1.3
Locomotion distance, session 73.34.24.22.1-2.0
Stereotopy head waving bouts, day 74.44.95.1-2.32.2
Stereotopy head waving duration, day 72.42.92.9-1.71.7
Locomotion velocity, session 80.20.20.20.5-0.4
Locomotion distance, session 81.62.32.31.5-1.5
Degree of sensitization distance0.60.60.7-0.80.7
Degree of sensitization stereotypy2.62.82.9-1.71.7
Conditioned locomotion0.20.20.30.5-0.5
Cocaine response after cond. corrected0.20.20.2-0.40.5
Cocaine response after cond. not corrected0.00.00.0-0.10.2
Cocaine response before conditioning1.51.82.01.4-1.3
Saline control response0.10.10.10.2-0.3
Bone: connectivity density0.10.10.10.4-0.4
Bone: cortical apparent density2.43.33.3-1.81.8
Bone: cortical area0.61.01.0-1.01.0
Bone: cortical porosity1.51.61.61.3-1.2
Bone: cortical porosity1.51.61.71.3-1.2
Bone: cortical thickness0.40.60.6-0.80.8
Bone: cortical thickness0.30.40.50.7-0.5
Bone: cortical tissue density2.23.03.1-1.71.8
Condit. Reinf. active minus inactive responses0.20.20.20.4-0.4
Condit. Reinf. active-inactive response ratio0.40.40.40.6-0.6
Condit. Reinf. active responses0.40.50.60.8-0.6
Condit. Reinf. inactive responses0.30.40.50.7-0.5
Incentive salience index mean0.00.00.00.1-0.0
Condit. Reinf. lever presses0.50.70.7-0.80.9
Condit. Reinf. active minus inactive responses1.11.41.5-1.21.1
Condit. Reinf. active-inactive response ratio0.40.40.5-0.70.6
Condit. Reinf. active responses0.91.31.5-1.21.1
Condit. Reinf. inactive responses0.10.10.1-0.30.4
Condit. Reinf. lever presses0.50.70.80.8-0.9
Condit. Reinf. lever reinforcers received0.20.30.4-0.60.5
Conditioned reinforcement - actives0.10.10.20.2-0.4
Conditioned reinforcement - inactives0.30.40.50.7-0.6
Conditioned locomotion0.30.40.50.5-0.7
Patch foraging indifference point 0 sec0.40.70.70.8-0.8
Patch foraging indifference point AUC0.40.50.6-0.70.7
Delay disc. indifference point, 0s delay0.00.00.0-0.20.1
Delay disc. indifference point, 16s delay0.10.10.1-0.30.1
Delay disc. indifference point, 2s delay5.46.06.4-2.42.5
Delay disc. indifference point, 24s delay0.00.00.0-0.10.2
Delay disc. indifference point, 4s delay0.10.10.2-0.40.3
Delay disc. indifference point, 8s delay0.20.20.30.4-0.6
Indifference point function ln k0.00.00.00.1-0.1
Indifference point function log k0.00.00.00.1-0.1
Patch foraging total patch changes 0 sec0.71.41.51.2-1.1
Patch foraging total patch changes 12 sec0.00.10.10.2-0.3
Patch foraging total patch changes 18 sec0.20.40.40.6-0.6
Patch foraging total patch changes 24 sec0.00.00.10.2-0.3
Patch foraging total patch changes 6 sec0.00.00.00.2-0.2
Patch foraging time to switch 0 sec0.10.20.3-0.40.5
Patch foraging water rate 0 sec0.00.00.00.1-0.1
Patch foraging water rate 12 sec0.61.21.31.1-1.0
Patch foraging water rate 18 sec0.00.00.00.1-0.1
Patch foraging water rate 24 sec0.20.30.4-0.60.4
Patch foraging water rate 6 sec0.30.40.40.7-0.6
Seeking ratio, delayed vs. immediate footshock0.00.00.00.1-0.2
Distance traveled before self-admin0.00.00.10.0-0.2
Distance traveled after self-admin2.63.23.91.6-2.0
Extensor digitorum longus weight7.931.131.7-5.55.6
Bone: elastic displacement4.85.55.92.3-2.4
Bone: elastic work2.53.23.31.8-1.8
Bone: endosteal estimation0.10.20.2-0.40.5
Bone: endosteal perimeter0.51.11.2-1.01.1
Epididymis fat weight2.89.69.63.1-3.1
Delta time in closed arm before/after self-admin0.10.00.1-0.2-0.2
Delta time in open arm before/after self-admin3.03.03.31.8-1.6
Diff in mean of infusions in LGA sessions1.01.21.3-1.11.1
Delay discount exponential model param0.20.20.30.5-0.4
Extinction: sum of active levers before priming1.21.31.3-1.21.1
Active lever presses in extinction session 60.20.20.30.4-0.5
Bone: final force0.20.30.3-0.50.5
Bone: final moment0.10.20.2-0.50.4
Food consumed during 24 hour testing period0.81.11.11.0-1.1
Glucose0.20.40.40.6-0.6
Heart weight0.20.30.30.5-0.5
Delay discount hyperbolic model param0.40.40.50.7-0.6
Intermittent access intake day 1-15 change0.51.11.11.0-1.1
Intermittent access intake escalation0.10.30.30.5-0.6
Intermittent access intake escalation 20.40.40.60.5-0.8
Intermitt. access day 1 inactive lever presses0.20.60.7-0.80.7
Intermitt. access day 15 inactive lever presses0.00.10.20.4-0.1
Intermitt. access escalation Index1.31.91.9-1.41.3
Intermittent access day 1 total infusions0.10.10.10.3-0.3
Intermittent access day 15 total infusions0.10.10.10.4-0.3
Intermittent access terminal intake (last 3 days)0.00.00.10.2-0.2
Intermittent access total infusions0.00.00.00.1-0.1
Intermittent access day 1 locomotion0.20.30.30.5-0.6
Intermittent access day 15 total locomotion2.03.63.71.9-1.9
Intermittent access total locomotion0.91.01.11.0-1.1
Intermittent access standard deviation0.91.91.91.4-1.4
Left kidney weight0.10.50.6-0.80.6
Right kidney weight0.31.41.4-1.21.2
Cocaine induced anxiety0.10.10.10.3-0.3
Post-drug Anxiety0.50.50.60.7-0.7
Baseline Anxiety0.00.00.0-0.10.2
Tail length0.20.91.01.0-1.0
Length with tail0.00.10.20.4-0.3
Length without tail0.00.00.0-0.10.1
Times rat made contact with spout0.91.01.01.0-1.0
Lifetime Intake0.10.20.20.4-0.4
Liver weight, left0.00.10.1-0.30.2
Liver weight, right0.00.00.0-0.00.0
Locomotor activity0.10.20.20.4-0.4
Locomotor testing distance0.50.90.91.0-0.9
Locomotor testing rearing0.40.80.90.9-0.8
Locomotion in novel chamber1.72.22.5-1.61.4
Locomotion in novel chamber post-restriction0.00.10.1-0.30.0
Fecal boli incidents, locomotor time 12.63.83.92.0-1.9
Change in fecal boli incidents, locomotor task0.70.70.8-0.70.9
Time >=10cm from walls, locomotor time 10.80.80.91.0-0.8
Bouts of movement, locomotor time 10.20.20.30.5-0.3
Total resting periods, locomotor time 10.70.81.01.0-0.7
Rest time, locomotor task time 10.70.81.01.0-0.8
Distance moved, locomotor task time 10.81.11.5-1.20.9
Vertical activity count, locomotor time 11.33.23.5-1.91.7
Time >=10cm from walls, locomotor time 20.30.50.60.7-0.6
Bouts of movement, locomotor time 21.21.92.0-1.41.4
Total resting periods, locomotor time 21.52.72.8-1.61.7
Rest time, locomotor task time 20.10.10.10.3-0.1
Distance moved, locomotor task time 20.10.10.1-0.30.2
Vertical activity count, locomotor time 20.40.50.6-0.80.6
Light reinforcement 10.00.00.00.10.1
Light reinforcement 20.00.00.00.10.1
Bone: marrow area0.10.20.2-0.40.4
Bone: maximum diameter0.30.50.6-0.70.8
Bone: maximum force0.71.31.3-1.11.1
Bone: maximum moment0.61.01.0-1.01.0
Mean time between licks in bursts0.71.71.71.3-1.3
Mean num. licks in bursts0.81.21.31.1-1.1
Cd content in liver0.40.50.50.7-0.7
Co content in liver0.10.10.2-0.30.4
Cu content in liver0.00.00.0-0.1-0.1
Fe content in liver0.10.20.20.4-0.5
K content in liver0.00.00.1-0.20.1
Mg content in liver0.40.40.40.6-0.6
Mn content in liver0.10.10.1-0.20.3
Na content in liver0.00.00.00.1-0.2
Rb content in liver0.40.50.70.6-0.8
Se content in liver0.81.01.01.0-1.0
Sr content in liver0.20.20.20.4-0.4
Zn content in liver1.01.21.21.1-1.1
Bone: minimum diameter0.61.21.2-1.01.1
Time in familiar zone, hab. session 10.30.30.40.6-0.4
Time in novel zone, hab. session 11.71.71.9-1.41.2
Total zone transitions, hab. session 10.70.91.1-0.91.0
Total locomotion distance, hab. session 10.10.20.30.5-0.3
Locomotion velocity, hab. session 10.20.30.40.6-0.4
Time in familiar zone, hab. session 20.20.20.20.4-0.4
Time in novel zone, hab. session 20.70.70.8-0.90.7
Total zone transitions, hab. session 20.10.20.30.5-0.3
Total locomotion distance, hab. session 20.20.20.30.6-0.3
Locomotion velocity, hab. session 20.30.40.60.8-0.5
Novel to familiar place preference ratio1.31.41.5-1.11.2
Novelty place preference0.80.91.0-0.91.0
Time in novel zone, NPP test1.01.11.2-1.01.1
Total zone transitions, NPP test0.30.40.50.7-0.5
Total locomotion distance, NPP test1.11.41.71.3-1.1
Locomotion velocity, NPP test1.31.82.21.5-1.2
Intraocular pressure1.42.02.01.4-1.4
Delta distance traveled before/after self-admin5.65.96.22.3-2.5
Delta ambulatory time before/after self-admin4.25.25.72.2-2.4
Parametrial fat weight1.53.54.01.7-2.0
Pavlov. Cond. lever latency1.11.31.31.2-1.2
Pavlov. Cond. magazine entry latency2.32.93.0-1.71.7
Pavlov. Cond. change in total contacts3.23.43.4-1.81.8
Pavlov. Cond. index score3.64.54.5-2.12.1
Pavlov. Cond. latency score3.13.94.0-2.02.0
Pavlov. Cond. lever contacts1.21.51.5-1.21.2
Pavlov. Cond. magazine entry number1.62.12.21.5-1.4
Pavlov. Cond. intertrial magazine entries1.82.22.21.5-1.5
Pavlov. Cond. lever-magazine prob. diff.3.54.34.4-2.12.0
Pavlov. Cond. response bias1.01.21.2-1.11.1
Pavlov. Cond. lever latency1.72.32.4-1.61.5
Pavlov. Cond. magazine entry latency2.22.62.71.7-1.6
Pavlov. Cond. change in total contacts0.60.90.9-0.91.0
Pavlov. Cond. index score1.52.02.11.5-1.3
Pavlov. Cond. latency score1.31.81.91.4-1.3
Pavlov. Cond. lever contacts2.33.13.41.8-1.7
Pavlov. Cond. magazine entry number0.60.80.8-0.90.9
Pavlov. Cond. intertrial magazine entries1.11.61.81.2-1.3
Pavlov. Cond. lever-magazine prob. diff.1.01.31.51.2-1.1
Pavlov. Cond. response bias2.02.72.71.7-1.6
Time in closed arm before self-admin2.53.23.3-1.81.8
Time in closed arm after self-admin3.13.33.7-1.91.7
Time in open arm before self-admin0.50.60.6-0.80.7
Time in open arm after self-admin0.60.60.70.8-0.7
Bone: periosteal estimation0.40.80.8-0.90.9
Bone: periosteal perimeter1.52.62.6-1.61.6
Bone: post-yield work0.20.30.3-0.60.5
Progressive ratio test 1 active lever presses1.01.31.41.2-1.1
Progressive ratio test 1 breakpoint1.41.71.81.3-1.2
Progressive ratio test 1 inactive lever presses0.20.30.3-0.50.5
Progressive ratio test 2 active lever presses0.00.00.00.2-0.2
Progressive ratio test 2 breakpoint0.00.00.0-0.00.1
Progressive ratio test 2 inactive lever presses0.30.50.50.7-0.6
Incentive Sensitization - Responses0.30.50.5-0.60.7
Incentive Sensitization - Breakpoint0.50.70.8-0.80.9
Sum of active levers in priming session hrs 5-60.20.20.2-0.40.5
Progressive ratio0.00.00.0-0.1-0.1
Food seeking constrained by brief footshock0.10.10.20.3-0.4
Seeking ratio, punishment vs. effort0.00.00.00.2-0.1
Retroperitoneal fat weight3.313.914.53.7-3.8
Reaction time number correct0.81.51.81.3-1.1
Reaction time mean minus median0.00.10.2-0.40.2
Reaction time mean minus median AUC0.10.30.4-0.60.5
Reaction time num false alarms0.10.20.20.5-0.4
Reaction time num false alarms AUC0.00.00.10.2-0.1
Reaction time trials correct on left0.81.51.81.3-1.1
Reaction time trials on left0.81.51.81.4-1.1
Reaction time mean0.20.30.4-0.60.4
Reaction time mean AUC0.20.30.5-0.70.5
Median of all reaction times0.10.20.2-0.50.3
Reaction time omissions0.10.10.10.3-0.3
Reaction time false alarm rate0.40.50.5-0.70.7
Reaction time premature initiation rate1.21.72.11.2-1.4
Reaction time premature initiations1.93.33.51.8-1.9
Std. dev. reaction times0.20.40.5-0.70.5
Reaction time trials completed0.81.51.81.4-1.1
Reaction time trials AUC0.61.11.41.2-0.9
Run reversals in cocaine runway, females0.00.00.0-0.2-0.1
Run reversals in cocaine runway, males2.72.72.8-1.71.6
Latency to leave start box in cocaine runway0.10.10.1-0.30.4
Latency to leave start box in cocaine runway, F0.20.20.2-0.40.5
Latency to leave start box in cocaine runway, M0.00.00.0-0.20.2
Std. dev. time between licks in bursts1.52.12.21.5-1.4
Total sessions with >9 infusions0.00.00.0-0.0-0.1
Short access day 1 total inactive lever presses0.10.10.20.2-0.4
Short access day 10 total inactive lever presses0.10.20.4-0.60.3
Short access day 1 total infusions0.20.30.30.5-0.6
Short access day 10 total infusions0.00.00.0-0.00.0
Short access total infusions0.40.50.60.7-0.8
Short access day 1 locomotion0.00.00.0-0.10.1
Short access day 10 total locomotion0.00.00.0-0.20.1
Short access total locomotion0.00.00.0-0.2-0.0
One hour access (0.3 mA shock)0.50.60.6-0.80.7
Compulsive drug intake0.70.80.9-0.90.8
One hour access (shock baseline)0.10.10.1-0.30.3
Social response proportion1.51.71.81.4-1.2
Social responses0.10.10.20.4-0.3
Social time0.70.91.11.1-0.9
Soleus weight0.00.00.00.1-0.1
Bone: stiffness2.44.04.2-1.92.0
Tibialis anterior weight11.338.338.4-6.26.2
Time to tail flick, vehicle, before self-admin0.20.20.3-0.60.3
Time to tail flick, vehicle, after self-admin0.30.40.6-0.50.8
Time to tail flick, test, before self-admin0.60.60.7-0.80.8
Time to tail flick, test, after self-admin0.91.01.1-1.00.9
Delta time to tail flick, vehicle, before/after SA0.20.10.30.5-0.2
Delta time to tail flick, test, before/after SA0.00.00.0-0.20.1
Tibia length0.00.00.00.1-0.1
Ambulatory time before self-admin0.10.20.30.3-0.5
Ambulatory time after self-admin2.93.44.31.6-2.1
Bone: tissue strength1.01.01.1-1.10.9
Total heroin consumption0.10.10.10.1-0.3
Bone: trabecular number0.10.20.20.4-0.4
Bone: trabecular spacing0.20.30.4-0.60.4
Bone: trabecular thickness0.30.40.5-0.50.7
Bone: trabecular tissue density2.94.24.6-2.02.2
Water consumed over 24 hours0.81.11.21.0-1.1
Number of responses in last shaping day0.00.00.00.20.2