Hub : Genes

Krt81

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Krt81	0.04	0.03	1.1e-03	0.03	0.04	0.03	0.04	9.1e-04	5.1e-04	2.1e-03	4.7e-04
2	Adipose	gene expression	Krt81	0.03	0.02	7.2e-04	0.02	0.02	0.02	0.02	2.7e-03	1.2e-03	4.4e-03	2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.1	0.2	0.2	-0.5	0.5
Area under the delay curve	0.1	0.1	0.2	-0.4	0.3
BMI with tail	1.8	6.3	6.5	-2.5	2.5
BMI without tail	0.4	2.2	2.2	-1.5	1.5
Body weight	0.5	2.1	2.2	-1.5	1.4
Weight adjusted by age	0.7	2.0	2.4	-1.3	1.5
Bone surface	0.2	0.3	0.4	-0.5	0.6
Bone volume	0.4	0.7	0.7	-0.8	0.9
Breakpoint value in progressive ratio session	0.0	0.0	0.0	0.0	-0.0
Number of licking bursts	0.0	0.0	0.1	-0.2	0.1
Context. condit. distance diff. score	0.0	0.1	0.1	0.1	-0.3
Locomotion velocity, session 1	3.8	4.2	4.8	2.2	-1.9
Locomotion distance, session 1	0.4	0.6	0.8	0.9	-0.6
Locomotion velocity, session 2	2.1	2.5	2.9	1.7	-1.5
Locomotion distance, session 2	0.7	1.0	1.2	1.1	-0.9
Locomotion velocity, session 3	5.0	5.7	6.1	2.5	-2.3
Locomotion distance, session 3	5.0	5.7	5.9	2.4	-2.3
Stereotopy head waving bouts, day 3	1.9	2.2	2.3	-1.5	1.5
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, session 7	1.3	1.4	1.6	1.1	-1.3
Locomotion distance, session 7	3.3	4.2	4.2	2.1	-2.0
Stereotopy head waving bouts, day 7	4.2	4.9	5.1	-2.3	2.2
Stereotopy head waving duration, day 7	2.3	2.9	2.9	-1.7	1.7
Locomotion velocity, session 8	0.2	0.2	0.2	0.5	-0.4
Locomotion distance, session 8	1.6	2.3	2.3	1.5	-1.5
Degree of sensitization distance	0.6	0.6	0.7	-0.8	0.7
Degree of sensitization stereotypy	2.6	2.8	2.9	-1.7	1.7
Conditioned locomotion	0.2	0.2	0.3	0.5	-0.5
Cocaine response after cond. corrected	0.2	0.2	0.2	-0.4	0.5
Cocaine response after cond. not corrected	0.0	0.0	0.0	-0.1	0.2
Cocaine response before conditioning	1.5	1.8	2.0	1.4	-1.3
Saline control response	0.1	0.1	0.1	0.2	-0.3
Bone: connectivity density	0.1	0.1	0.1	0.4	-0.4
Bone: cortical apparent density	2.1	3.3	3.3	-1.8	1.8
Bone: cortical area	0.6	1.0	1.0	-1.0	1.0
Bone: cortical porosity	1.5	1.6	1.6	1.3	-1.2
Bone: cortical porosity	1.5	1.6	1.7	1.3	-1.2
Bone: cortical thickness	0.4	0.6	0.6	-0.8	0.8
Bone: cortical thickness	0.3	0.4	0.5	0.7	-0.5
Bone: cortical tissue density	1.9	3.0	3.1	-1.7	1.8
Condit. Reinf. active minus inactive responses	0.2	0.2	0.2	0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.4	0.6	-0.6
Condit. Reinf. active responses	0.4	0.5	0.6	0.8	-0.6
Condit. Reinf. inactive responses	0.3	0.4	0.5	0.7	-0.5
Incentive salience index mean	0.0	0.0	0.0	0.1	-0.0
Condit. Reinf. lever presses	0.5	0.7	0.7	-0.8	0.9
Condit. Reinf. active minus inactive responses	0.9	1.4	1.5	-1.2	1.1
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	-0.7	0.6
Condit. Reinf. active responses	0.9	1.3	1.5	-1.2	1.1
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.3	0.4
Condit. Reinf. lever presses	0.5	0.7	0.8	0.8	-0.9
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	-0.6	0.5
Conditioned reinforcement - actives	0.0	0.1	0.2	0.2	-0.4
Conditioned reinforcement - inactives	0.2	0.4	0.5	0.7	-0.6
Conditioned locomotion	0.3	0.4	0.5	0.5	-0.7
Patch foraging indifference point 0 sec	0.2	0.7	0.7	0.8	-0.8
Patch foraging indifference point AUC	0.2	0.5	0.6	-0.7	0.7
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.2	0.1
Delay disc. indifference point, 16s delay	0.0	0.1	0.1	-0.3	0.1
Delay disc. indifference point, 2s delay	5.4	6.0	6.4	-2.4	2.5
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	-0.1	0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	0.3
Delay disc. indifference point, 8s delay	0.1	0.2	0.3	0.4	-0.6
Indifference point function ln k	0.0	0.0	0.0	0.1	-0.1
Indifference point function log k	0.0	0.0	0.0	0.1	-0.1
Patch foraging total patch changes 0 sec	0.5	1.4	1.5	1.2	-1.1
Patch foraging total patch changes 12 sec	0.0	0.1	0.1	0.2	-0.3
Patch foraging total patch changes 18 sec	0.1	0.4	0.4	0.6	-0.6
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	0.2	-0.3
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	0.2	-0.2
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.4	0.5
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.1	-0.1
Patch foraging water rate 12 sec	0.3	1.2	1.3	1.1	-1.0
Patch foraging water rate 18 sec	0.0	0.0	0.0	0.1	-0.1
Patch foraging water rate 24 sec	0.2	0.3	0.4	-0.6	0.4
Patch foraging water rate 6 sec	0.3	0.4	0.4	0.7	-0.6
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.1	-0.2
Distance traveled before self-admin	0.0	0.0	0.1	0.0	-0.2
Distance traveled after self-admin	1.8	3.2	3.9	1.6	-2.0
Extensor digitorum longus weight	7.8	31.1	31.7	-5.5	5.6
Bone: elastic displacement	4.3	5.5	5.9	2.3	-2.4
Bone: elastic work	2.5	3.2	3.3	1.8	-1.8
Bone: endosteal estimation	0.1	0.2	0.2	-0.4	0.5
Bone: endosteal perimeter	0.5	1.1	1.2	-1.0	1.1
Epididymis fat weight	1.9	9.6	9.6	3.1	-3.1
Delta time in closed arm before/after self-admin	0.1	0.0	0.1	-0.2	-0.2
Delta time in open arm before/after self-admin	2.5	3.0	3.3	1.8	-1.6
Diff in mean of infusions in LGA sessions	0.7	1.2	1.3	-1.1	1.1
Delay discount exponential model param	0.2	0.2	0.3	0.5	-0.4
Extinction: sum of active levers before priming	0.9	1.3	1.3	-1.2	1.1
Active lever presses in extinction session 6	0.2	0.2	0.3	0.4	-0.5
Bone: final force	0.2	0.3	0.3	-0.5	0.5
Bone: final moment	0.1	0.2	0.2	-0.5	0.4
Food consumed during 24 hour testing period	0.5	1.1	1.1	1.0	-1.1
Glucose	0.2	0.4	0.4	0.6	-0.6
Heart weight	0.2	0.3	0.3	0.5	-0.5
Delay discount hyperbolic model param	0.3	0.4	0.5	0.7	-0.6
Intermittent access intake day 1-15 change	0.2	1.1	1.1	1.0	-1.1
Intermittent access intake escalation	0.0	0.3	0.3	0.5	-0.6
Intermittent access intake escalation 2	0.2	0.4	0.6	0.5	-0.8
Intermitt. access day 1 inactive lever presses	0.0	0.6	0.7	-0.8	0.7
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	0.4	-0.1
Intermitt. access escalation Index	0.6	1.9	1.9	-1.4	1.3
Intermittent access day 1 total infusions	0.0	0.1	0.1	0.3	-0.3
Intermittent access day 15 total infusions	0.0	0.1	0.1	0.4	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.2	-0.2
Intermittent access total infusions	0.0	0.0	0.0	0.1	-0.1
Intermittent access day 1 locomotion	0.2	0.3	0.3	0.5	-0.6
Intermittent access day 15 total locomotion	0.9	3.6	3.7	1.9	-1.9
Intermittent access total locomotion	0.9	1.0	1.1	1.0	-1.1
Intermittent access standard deviation	0.4	1.9	1.9	1.4	-1.4
Left kidney weight	0.1	0.5	0.6	-0.8	0.6
Right kidney weight	0.2	1.4	1.4	-1.2	1.2
Cocaine induced anxiety	0.0	0.1	0.1	0.3	-0.3
Post-drug Anxiety	0.5	0.5	0.6	0.7	-0.7
Baseline Anxiety	0.0	0.0	0.0	-0.1	0.2
Tail length	0.2	0.9	1.0	1.0	-1.0
Length with tail	0.0	0.1	0.2	0.4	-0.3
Length without tail	0.0	0.0	0.0	-0.1	0.1
Times rat made contact with spout	0.9	1.0	1.0	1.0	-1.0
Lifetime Intake	0.1	0.2	0.2	0.4	-0.4
Liver weight, left	0.0	0.1	0.1	-0.3	0.2
Liver weight, right	0.0	0.0	0.0	-0.0	0.0
Locomotor activity	0.1	0.2	0.2	0.4	-0.4
Locomotor testing distance	0.4	0.9	0.9	1.0	-0.9
Locomotor testing rearing	0.2	0.8	0.9	0.9	-0.8
Locomotion in novel chamber	1.6	2.2	2.5	-1.6	1.4
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	-0.3	0.0
Fecal boli incidents, locomotor time 1	1.5	3.8	3.9	2.0	-1.9
Change in fecal boli incidents, locomotor task	0.6	0.7	0.8	-0.7	0.9
Time >=10cm from walls, locomotor time 1	0.6	0.8	0.9	1.0	-0.8
Bouts of movement, locomotor time 1	0.1	0.2	0.3	0.5	-0.3
Total resting periods, locomotor time 1	0.7	0.8	1.0	1.0	-0.7
Rest time, locomotor task time 1	0.5	0.8	1.0	1.0	-0.8
Distance moved, locomotor task time 1	0.4	1.1	1.5	-1.2	0.9
Vertical activity count, locomotor time 1	0.5	3.2	3.5	-1.9	1.7
Time >=10cm from walls, locomotor time 2	0.2	0.5	0.6	0.7	-0.6
Bouts of movement, locomotor time 2	0.6	1.9	2.0	-1.4	1.4
Total resting periods, locomotor time 2	0.7	2.7	2.8	-1.6	1.7
Rest time, locomotor task time 2	0.0	0.1	0.1	0.3	-0.1
Distance moved, locomotor task time 2	0.1	0.1	0.1	-0.3	0.2
Vertical activity count, locomotor time 2	0.2	0.5	0.6	-0.8	0.6
Light reinforcement 1	0.0	0.0	0.0	0.1	0.1
Light reinforcement 2	0.0	0.0	0.0	0.1	0.1
Bone: marrow area	0.1	0.2	0.2	-0.4	0.4
Bone: maximum diameter	0.3	0.5	0.6	-0.7	0.8
Bone: maximum force	0.6	1.3	1.3	-1.1	1.1
Bone: maximum moment	0.5	1.0	1.0	-1.0	1.0
Mean time between licks in bursts	0.3	1.7	1.7	1.3	-1.3
Mean num. licks in bursts	0.5	1.2	1.3	1.1	-1.1
Cd content in liver	0.4	0.5	0.5	0.7	-0.7
Co content in liver	0.1	0.1	0.2	-0.3	0.4
Cu content in liver	0.0	0.0	0.0	-0.1	-0.1
Fe content in liver	0.1	0.2	0.2	0.4	-0.5
K content in liver	0.0	0.0	0.1	-0.2	0.1
Mg content in liver	0.3	0.4	0.4	0.6	-0.6
Mn content in liver	0.1	0.1	0.1	-0.2	0.3
Na content in liver	0.0	0.0	0.0	0.1	-0.2
Rb content in liver	0.4	0.5	0.7	0.6	-0.8
Se content in liver	0.8	1.0	1.0	1.0	-1.0
Sr content in liver	0.2	0.2	0.2	0.4	-0.4
Zn content in liver	1.0	1.2	1.2	1.1	-1.1
Bone: minimum diameter	0.6	1.2	1.2	-1.0	1.1
Time in familiar zone, hab. session 1	0.3	0.3	0.4	0.6	-0.4
Time in novel zone, hab. session 1	1.5	1.7	1.9	-1.4	1.2
Total zone transitions, hab. session 1	0.7	0.9	1.1	-0.9	1.0
Total locomotion distance, hab. session 1	0.1	0.2	0.3	0.5	-0.3
Locomotion velocity, hab. session 1	0.2	0.3	0.4	0.6	-0.4
Time in familiar zone, hab. session 2	0.1	0.2	0.2	0.4	-0.4
Time in novel zone, hab. session 2	0.6	0.7	0.8	-0.9	0.7
Total zone transitions, hab. session 2	0.1	0.2	0.3	0.5	-0.3
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.6	-0.3
Locomotion velocity, hab. session 2	0.3	0.4	0.6	0.8	-0.5
Novel to familiar place preference ratio	1.1	1.4	1.5	-1.1	1.2
Novelty place preference	0.7	0.9	1.0	-0.9	1.0
Time in novel zone, NPP test	0.9	1.1	1.2	-1.0	1.1
Total zone transitions, NPP test	0.3	0.4	0.5	0.7	-0.5
Total locomotion distance, NPP test	1.0	1.4	1.7	1.3	-1.1
Locomotion velocity, NPP test	1.3	1.8	2.2	1.5	-1.2
Intraocular pressure	1.2	2.0	2.0	1.4	-1.4
Delta distance traveled before/after self-admin	5.3	5.9	6.2	2.3	-2.5
Delta ambulatory time before/after self-admin	3.0	5.2	5.7	2.2	-2.4
Parametrial fat weight	1.5	3.5	4.0	1.7	-2.0
Pavlov. Cond. lever latency	1.1	1.3	1.3	1.2	-1.2
Pavlov. Cond. magazine entry latency	2.3	2.9	3.0	-1.7	1.7
Pavlov. Cond. change in total contacts	3.1	3.4	3.4	-1.8	1.8
Pavlov. Cond. index score	3.5	4.5	4.5	-2.1	2.1
Pavlov. Cond. latency score	3.1	3.9	4.0	-2.0	2.0
Pavlov. Cond. lever contacts	1.2	1.5	1.5	-1.2	1.2
Pavlov. Cond. magazine entry number	1.6	2.1	2.2	1.5	-1.4
Pavlov. Cond. intertrial magazine entries	1.8	2.2	2.2	1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.3	4.4	-2.1	2.0
Pavlov. Cond. response bias	1.0	1.2	1.2	-1.1	1.1
Pavlov. Cond. lever latency	1.6	2.3	2.4	-1.6	1.5
Pavlov. Cond. magazine entry latency	1.8	2.6	2.7	1.7	-1.6
Pavlov. Cond. change in total contacts	0.4	0.9	0.9	-0.9	1.0
Pavlov. Cond. index score	1.2	2.0	2.1	1.5	-1.3
Pavlov. Cond. latency score	1.1	1.8	1.9	1.4	-1.3
Pavlov. Cond. lever contacts	2.1	3.1	3.4	1.8	-1.7
Pavlov. Cond. magazine entry number	0.6	0.8	0.8	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.7	1.6	1.8	1.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.3	1.5	1.2	-1.1
Pavlov. Cond. response bias	1.9	2.7	2.7	1.7	-1.6
Time in closed arm before self-admin	1.9	3.2	3.3	-1.8	1.8
Time in closed arm after self-admin	2.9	3.3	3.7	-1.9	1.7
Time in open arm before self-admin	0.5	0.6	0.6	-0.8	0.7
Time in open arm after self-admin	0.6	0.6	0.7	0.8	-0.7
Bone: periosteal estimation	0.3	0.8	0.8	-0.9	0.9
Bone: periosteal perimeter	1.3	2.6	2.6	-1.6	1.6
Bone: post-yield work	0.2	0.3	0.3	-0.6	0.5
Progressive ratio test 1 active lever presses	0.7	1.3	1.4	1.2	-1.1
Progressive ratio test 1 breakpoint	1.0	1.7	1.8	1.3	-1.2
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.3	-0.5	0.5
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.2	-0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.0	0.1
Progressive ratio test 2 inactive lever presses	0.1	0.5	0.5	0.7	-0.6
Incentive Sensitization - Responses	0.2	0.5	0.5	-0.6	0.7
Incentive Sensitization - Breakpoint	0.3	0.7	0.8	-0.8	0.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	-0.4	0.5
Progressive ratio	0.0	0.0	0.0	-0.1	-0.1
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.3	-0.4
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.2	-0.1
Retroperitoneal fat weight	3.1	13.9	14.5	3.7	-3.8
Reaction time number correct	0.4	1.5	1.8	1.3	-1.1
Reaction time mean minus median	0.0	0.1	0.2	-0.4	0.2
Reaction time mean minus median AUC	0.0	0.3	0.4	-0.6	0.5
Reaction time num false alarms	0.1	0.2	0.2	0.5	-0.4
Reaction time num false alarms AUC	0.0	0.0	0.1	0.2	-0.1
Reaction time trials correct on left	0.4	1.5	1.8	1.3	-1.1
Reaction time trials on left	0.4	1.5	1.8	1.4	-1.1
Reaction time mean	0.1	0.3	0.4	-0.6	0.4
Reaction time mean AUC	0.1	0.3	0.5	-0.7	0.5
Median of all reaction times	0.1	0.2	0.2	-0.5	0.3
Reaction time omissions	0.1	0.1	0.1	0.3	-0.3
Reaction time false alarm rate	0.4	0.5	0.5	-0.7	0.7
Reaction time premature initiation rate	1.1	1.7	2.1	1.2	-1.4
Reaction time premature initiations	1.1	3.3	3.5	1.8	-1.9
Std. dev. reaction times	0.1	0.4	0.5	-0.7	0.5
Reaction time trials completed	0.4	1.5	1.8	1.4	-1.1
Reaction time trials AUC	0.3	1.1	1.4	1.2	-0.9
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.2	-0.1
Run reversals in cocaine runway, males	2.5	2.7	2.8	-1.7	1.6
Latency to leave start box in cocaine runway	0.1	0.1	0.1	-0.3	0.4
Latency to leave start box in cocaine runway, F	0.1	0.2	0.2	-0.4	0.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.2	0.2
Std. dev. time between licks in bursts	1.1	2.1	2.2	1.5	-1.4
Total sessions with >9 infusions	0.0	0.0	0.0	-0.0	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.2	-0.4
Short access day 10 total inactive lever presses	0.0	0.2	0.4	-0.6	0.3
Short access day 1 total infusions	0.2	0.3	0.3	0.5	-0.6
Short access day 10 total infusions	0.0	0.0	0.0	-0.0	0.0
Short access total infusions	0.4	0.5	0.6	0.7	-0.8
Short access day 1 locomotion	0.0	0.0	0.0	-0.1	0.1
Short access day 10 total locomotion	0.0	0.0	0.0	-0.2	0.1
Short access total locomotion	0.0	0.0	0.0	-0.2	-0.0
One hour access (0.3 mA shock)	0.5	0.6	0.6	-0.8	0.7
Compulsive drug intake	0.5	0.8	0.9	-0.9	0.8
One hour access (shock baseline)	0.0	0.1	0.1	-0.3	0.3
Social response proportion	1.3	1.7	1.8	1.4	-1.2
Social responses	0.1	0.1	0.2	0.4	-0.3
Social time	0.6	0.9	1.1	1.1	-0.9
Soleus weight	0.0	0.0	0.0	0.1	-0.1
Bone: stiffness	2.2	4.0	4.2	-1.9	2.0
Tibialis anterior weight	11.1	38.3	38.4	-6.2	6.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	-0.6	0.3
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.6	-0.5	0.8
Time to tail flick, test, before self-admin	0.5	0.6	0.7	-0.8	0.8
Time to tail flick, test, after self-admin	0.9	1.0	1.1	-1.0	0.9
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.5	-0.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	-0.2	0.1
Tibia length	0.0	0.0	0.0	0.1	-0.1
Ambulatory time before self-admin	0.1	0.2	0.3	0.3	-0.5
Ambulatory time after self-admin	2.1	3.4	4.3	1.6	-2.1
Bone: tissue strength	1.0	1.0	1.1	-1.1	0.9
Total heroin consumption	0.1	0.1	0.1	0.1	-0.3
Bone: trabecular number	0.1	0.2	0.2	0.4	-0.4
Bone: trabecular spacing	0.2	0.3	0.4	-0.6	0.4
Bone: trabecular thickness	0.3	0.4	0.5	-0.5	0.7
Bone: trabecular tissue density	2.4	4.2	4.6	-2.0	2.2
Water consumed over 24 hours	0.6	1.1	1.2	1.0	-1.1
Number of responses in last shaping day	0.0	0.0	0.0	0.2	0.2