Hub : Genes

Acvrl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Acvrl1	0.07	0.05	3.2e-05	0.04	0.04	0.04	0.04	8.0e-05	2.6e-05	5.4e-05	4.2e-05
2	IC	isoform ratio	XM_039078444.2	0.28	0.14	7.4e-03	0.03	0.05	0.04	0.04	2.9e-02	4.9e-03	1.0e-02	6.1e-03
3	IC	gene expression	Acvrl1	0.61	0.15	9.2e-04	0.01	0.02	0.01	0.01	1.0e-01	4.1e-02	1.2e-01	1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.9	1.6	2.2	-1.5	1.4	-0.8
Area under the delay curve	0.1	0.2	0.4	-0.4	0.4	-0.6
BMI with tail	1.9	6.7	13.4	-3.7	0.2	2.6
BMI without tail	0.5	2.7	5.2	-2.3	-0.3	1.7
Body weight	1.0	4.4	9.7	-3.1	1.4	1.2
Weight adjusted by age	0.4	1.1	2.0	-1.4	-1.0	0.7
Bone surface	1.0	2.1	3.4	-1.8	1.6	-0.3
Bone volume	0.9	1.8	4.1	-2.0	1.1	-0.1
Breakpoint value in progressive ratio session	0.0	0.1	0.2	-0.2	0.4	-0.1
Number of licking bursts	0.2	0.7	1.5	0.4	-1.2	0.7
Context. condit. distance diff. score	0.2	0.2	0.5	-0.3	0.7	0.3
Locomotion velocity, session 1	1.5	1.7	4.4	2.1	0.8	-0.4
Locomotion distance, session 1	0.6	0.7	1.2	1.1	-0.6	0.8
Locomotion velocity, session 2	1.4	1.7	2.2	1.5	1.2	-1.2
Locomotion distance, session 2	0.7	1.0	2.3	1.5	-0.6	0.6
Locomotion velocity, session 3	2.6	3.0	6.4	2.5	0.9	-1.3
Locomotion distance, session 3	3.8	4.3	5.7	2.3	1.5	-2.4
Stereotopy head waving bouts, day 3	3.3	3.9	6.3	-1.1	-2.1	2.5
Stereotopy head waving duration, day 3	1.0	1.2	2.6	-0.0	-1.0	1.6
Locomotion velocity, session 7	1.1	1.2	2.1	1.4	0.3	-1.1
Locomotion distance, session 7	2.2	2.8	5.9	2.4	1.0	-1.2
Stereotopy head waving bouts, day 7	2.8	3.3	5.1	-2.3	-1.8	1.2
Stereotopy head waving duration, day 7	1.7	2.1	3.3	-1.8	-1.3	1.2
Locomotion velocity, session 8	0.0	0.0	0.1	0.3	0.0	0.0
Locomotion distance, session 8	0.6	0.9	2.0	1.4	0.9	-0.2
Degree of sensitization distance	1.1	1.2	2.9	-0.5	-0.7	1.7
Degree of sensitization stereotypy	1.4	1.6	3.6	-1.9	-1.0	0.3
Conditioned locomotion	0.3	0.3	0.8	0.4	-0.2	0.9
Cocaine response after cond. corrected	0.4	0.5	0.9	-0.3	-0.8	0.9
Cocaine response after cond. not corrected	0.1	0.2	0.3	0.0	-0.6	0.5
Cocaine response before conditioning	1.0	1.2	2.0	1.4	0.8	-0.9
Saline control response	0.0	0.0	0.0	0.1	0.1	-0.2
Bone: connectivity density	1.1	1.7	3.3	-0.4	1.8	-1.3
Bone: cortical apparent density	3.4	5.3	8.6	-1.2	-2.4	2.9
Bone: cortical area	0.7	1.2	3.1	-1.8	0.7	-0.1
Bone: cortical porosity	1.4	1.5	2.0	0.8	1.4	-1.4
Bone: cortical porosity	1.1	1.2	1.6	0.9	1.3	-1.1
Bone: cortical thickness	0.3	0.5	1.3	-1.1	0.3	0.1
Bone: cortical thickness	0.3	0.3	0.4	0.6	0.5	-0.5
Bone: cortical tissue density	3.2	5.1	8.4	-1.2	-2.4	2.9
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.2	0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.4	0.3	1.1	-1.2
Condit. Reinf. active responses	0.1	0.2	0.4	0.6	0.4	-0.1
Condit. Reinf. inactive responses	0.6	0.8	0.9	1.0	-0.7	1.0
Incentive salience index mean	0.1	0.2	0.2	-0.2	0.4	-0.5
Condit. Reinf. lever presses	0.3	0.5	0.9	-1.0	-0.3	0.6
Condit. Reinf. active minus inactive responses	0.7	1.1	1.6	-1.3	-0.5	1.2
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	-0.8	-0.1	0.7
Condit. Reinf. active responses	0.7	1.0	1.2	-1.1	-0.8	1.1
Condit. Reinf. inactive responses	0.2	0.3	0.4	-0.2	-0.6	0.6
Condit. Reinf. lever presses	0.3	0.5	0.7	0.8	0.7	-0.5
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	-0.5	-0.4	0.8
Conditioned reinforcement - actives	0.1	0.2	0.5	0.7	-0.2	-0.3
Conditioned reinforcement - inactives	0.3	0.8	2.0	1.4	-0.5	-0.4
Conditioned locomotion	0.3	0.5	0.9	0.9	0.4	-0.6
Patch foraging indifference point 0 sec	0.3	0.7	1.7	1.3	-0.5	-0.4
Patch foraging indifference point AUC	0.3	0.7	1.3	-0.2	-1.2	0.8
Delay disc. indifference point, 0s delay	0.8	0.9	1.9	-0.4	0.8	-1.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	-0.2	0.5	-0.7
Delay disc. indifference point, 2s delay	4.1	4.6	6.6	-2.6	-1.9	1.9
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.1	0.3	0.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.5	0.3	-0.6
Delay disc. indifference point, 8s delay	0.5	0.9	1.3	0.2	1.1	-1.1
Indifference point function ln k	0.2	0.7	1.3	-0.9	1.2	-0.2
Indifference point function log k	0.2	0.7	1.3	-0.9	1.2	-0.2
Patch foraging total patch changes 0 sec	0.3	0.9	2.5	1.6	-0.2	-0.6
Patch foraging total patch changes 12 sec	0.6	0.8	1.0	1.0	-1.0	0.7
Patch foraging total patch changes 18 sec	0.3	0.8	1.8	1.3	-0.6	-0.4
Patch foraging total patch changes 24 sec	0.1	0.4	0.7	0.8	-0.6	0.0
Patch foraging total patch changes 6 sec	0.6	1.0	1.3	1.1	-1.1	0.5
Patch foraging time to switch 0 sec	0.2	0.7	1.9	-0.0	-1.4	0.5
Patch foraging water rate 0 sec	0.2	0.7	1.7	-0.6	1.3	0.2
Patch foraging water rate 12 sec	0.4	1.7	4.0	0.1	2.0	-1.0
Patch foraging water rate 18 sec	0.1	0.1	0.4	-0.1	0.2	0.6
Patch foraging water rate 24 sec	0.4	0.6	1.2	-1.1	0.6	0.5
Patch foraging water rate 6 sec	1.7	2.5	4.8	-0.5	2.2	-1.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.6	-0.1	0.8	-0.6
Distance traveled before self-admin	0.1	0.3	0.5	0.7	-0.5	-0.4
Distance traveled after self-admin	1.5	2.6	3.9	2.0	1.5	-1.3
Extensor digitorum longus weight	6.0	23.8	40.1	-6.3	-3.4	4.4
Bone: elastic displacement	2.2	2.8	8.0	2.8	0.7	-0.3
Bone: elastic work	1.7	2.2	3.3	1.8	1.6	-1.0
Bone: endosteal estimation	0.7	1.7	2.7	-1.6	1.4	-0.5
Bone: endosteal perimeter	0.7	1.6	4.3	-2.1	0.7	-0.1
Epididymis fat weight	1.6	8.1	13.9	2.3	3.7	-2.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.1	0.4	-0.5
Delta time in open arm before/after self-admin	1.4	1.7	3.1	1.7	1.2	-0.8
Diff in mean of infusions in LGA sessions	0.5	0.9	1.7	-1.3	-0.4	0.9
Delay discount exponential model param	0.1	0.2	0.2	0.5	-0.2	0.5
Extinction: sum of active levers before priming	0.7	1.0	2.2	-1.5	-0.1	0.9
Active lever presses in extinction session 6	0.5	0.5	0.7	0.5	0.7	-0.9
Bone: final force	1.4	2.3	3.9	-1.7	2.0	-0.6
Bone: final moment	1.6	2.6	4.5	-1.7	2.1	-0.8
Food consumed during 24 hour testing period	0.7	1.5	4.0	0.4	2.0	-0.5
Glucose	0.1	0.2	0.3	0.6	0.3	0.1
Heart weight	0.8	1.3	2.4	0.2	1.2	-1.5
Delay discount hyperbolic model param	0.1	0.2	0.4	0.7	0.0	0.2
Intermittent access intake day 1-15 change	0.1	0.8	1.6	0.7	1.3	-0.4
Intermittent access intake escalation	0.1	0.4	1.0	0.2	1.0	-0.4
Intermittent access intake escalation 2	0.9	1.5	2.6	0.5	1.2	-1.6
Intermitt. access day 1 inactive lever presses	0.0	0.4	0.7	-0.2	-0.8	0.7
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.3	-0.0	-0.3
Intermitt. access escalation Index	0.3	0.9	1.5	-1.0	-1.2	0.3
Intermittent access day 1 total infusions	0.1	0.3	0.5	0.7	-0.6	-0.2
Intermittent access day 15 total infusions	0.0	0.1	0.2	0.4	-0.2	0.3
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	0.4	-0.3	-0.0
Intermittent access total infusions	0.2	0.2	0.4	0.4	-0.6	0.2
Intermittent access day 1 locomotion	0.2	0.4	1.0	1.0	-0.2	-0.1
Intermittent access day 15 total locomotion	0.7	2.8	3.4	1.8	1.5	-1.7
Intermittent access total locomotion	0.7	0.9	2.4	1.6	0.1	-0.5
Intermittent access standard deviation	0.6	3.0	4.8	1.4	1.5	-2.2
Left kidney weight	0.2	1.3	2.3	-1.5	1.1	-0.6
Right kidney weight	0.5	3.5	6.4	-2.5	1.7	-1.0
Cocaine induced anxiety	0.2	0.5	1.3	-0.5	1.1	-0.2
Post-drug Anxiety	0.9	1.1	2.5	-0.2	1.6	-0.8
Baseline Anxiety	0.0	0.0	0.0	-0.2	-0.0	0.2
Tail length	0.2	0.8	1.8	0.4	0.7	-1.3
Length with tail	0.2	1.1	2.1	-0.8	1.4	-0.7
Length without tail	0.4	2.2	4.3	-1.4	2.1	-0.6
Times rat made contact with spout	0.8	0.9	1.5	0.7	1.2	-0.9
Lifetime Intake	0.3	0.3	0.8	0.9	-0.4	-0.2
Liver weight, left	1.7	3.0	4.3	-1.5	2.1	-1.5
Liver weight, right	0.6	1.0	1.9	-0.6	1.4	-0.9
Locomotor activity	0.2	0.4	0.7	0.8	-0.0	-0.6
Locomotor testing distance	0.4	1.1	2.1	1.5	0.1	-1.0
Locomotor testing rearing	0.3	1.0	1.6	1.1	0.4	-1.3
Locomotion in novel chamber	0.8	1.1	3.2	-1.8	0.0	-0.2
Locomotion in novel chamber post-restriction	0.1	0.2	0.3	0.3	0.5	-0.3
Fecal boli incidents, locomotor time 1	0.8	2.2	3.5	1.9	1.4	-1.0
Change in fecal boli incidents, locomotor task	0.9	1.0	1.2	-0.7	-1.1	1.1
Time >=10cm from walls, locomotor time 1	0.3	0.4	0.6	0.8	0.1	0.8
Bouts of movement, locomotor time 1	0.3	0.4	0.8	0.5	0.4	-0.9
Total resting periods, locomotor time 1	0.5	0.6	1.0	1.0	0.3	-0.8
Rest time, locomotor task time 1	0.3	0.4	1.0	1.0	0.2	-0.5
Distance moved, locomotor task time 1	0.2	0.5	0.8	-0.6	-0.9	0.5
Vertical activity count, locomotor time 1	0.2	1.7	2.9	-1.7	-1.0	1.1
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.6	0.8	0.2	-0.5
Bouts of movement, locomotor time 2	0.4	1.4	2.9	-1.7	-0.4	1.1
Total resting periods, locomotor time 2	0.4	1.8	3.9	-2.0	-0.5	1.0
Rest time, locomotor task time 2	0.1	0.1	0.2	0.1	-0.3	0.4
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.0	-0.3	-0.1
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.5	-0.2	0.3
Light reinforcement 1	0.1	0.3	0.5	0.7	-0.7	-0.1
Light reinforcement 2	0.0	0.0	0.1	-0.0	0.0	-0.3
Bone: marrow area	0.6	1.6	2.4	-1.6	1.4	-0.5
Bone: maximum diameter	0.3	0.6	1.6	-1.3	0.0	0.4
Bone: maximum force	1.3	2.6	5.5	-2.3	1.5	0.1
Bone: maximum moment	1.5	2.8	5.4	-2.3	1.7	-0.2
Mean time between licks in bursts	0.2	0.9	2.4	1.5	0.5	-0.3
Mean num. licks in bursts	0.8	2.2	4.3	0.4	2.1	-1.4
Cd content in liver	0.1	0.1	0.3	0.6	0.1	0.2
Co content in liver	0.1	0.2	0.2	-0.4	-0.3	0.5
Cu content in liver	0.5	0.6	1.4	-0.3	0.5	-1.2
Fe content in liver	0.7	0.8	1.6	0.9	-0.5	-1.2
K content in liver	0.1	0.1	0.1	-0.1	0.0	-0.4
Mg content in liver	0.2	0.2	0.3	0.6	0.4	0.2
Mn content in liver	0.1	0.1	0.3	-0.3	-0.2	0.6
Na content in liver	1.2	1.4	3.6	-0.1	0.8	-1.9
Rb content in liver	0.2	0.3	0.7	0.8	0.1	-0.4
Se content in liver	0.8	1.0	2.0	1.4	0.1	-1.0
Sr content in liver	1.5	1.3	2.8	0.1	1.0	-1.7
Zn content in liver	0.4	0.5	1.4	1.2	0.4	-0.1
Bone: minimum diameter	0.8	1.5	4.0	-2.0	0.7	-0.1
Time in familiar zone, hab. session 1	0.2	0.3	0.4	0.4	0.6	0.5
Time in novel zone, hab. session 1	1.4	1.6	2.4	-1.1	-1.6	1.1
Total zone transitions, hab. session 1	0.7	1.0	1.6	-0.7	-1.3	0.9
Total locomotion distance, hab. session 1	0.1	0.2	0.3	0.6	-0.2	0.4
Locomotion velocity, hab. session 1	0.1	0.1	0.4	0.6	0.1	-0.0
Time in familiar zone, hab. session 2	0.5	0.6	1.6	-0.1	1.3	0.2
Time in novel zone, hab. session 2	1.3	1.4	3.3	-0.3	-1.8	0.9
Total zone transitions, hab. session 2	0.1	0.2	0.3	0.6	0.0	-0.4
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.7	-0.3	0.5
Locomotion velocity, hab. session 2	0.2	0.2	0.7	0.9	0.1	-0.0
Novel to familiar place preference ratio	0.7	0.9	2.4	-1.5	-0.6	0.1
Novelty place preference	0.5	0.6	1.7	-1.3	-0.5	-0.0
Time in novel zone, NPP test	0.6	0.8	1.8	-1.3	-0.7	0.2
Total zone transitions, NPP test	0.4	0.6	1.6	1.3	-0.6	0.1
Total locomotion distance, NPP test	0.9	1.3	3.8	2.0	-0.3	0.0
Locomotion velocity, NPP test	1.0	1.4	3.9	2.0	0.2	-0.4
Intraocular pressure	0.8	1.3	3.8	1.9	-0.0	0.4
Delta distance traveled before/after self-admin	4.3	4.7	7.3	1.9	2.7	-1.8
Delta ambulatory time before/after self-admin	2.6	4.5	6.1	1.9	2.5	-1.9
Parametrial fat weight	0.9	2.2	4.3	2.1	1.1	1.0
Pavlov. Cond. lever latency	0.5	0.6	1.4	1.2	0.5	-0.4
Pavlov. Cond. magazine entry latency	1.4	1.8	3.7	-1.9	-0.9	1.0
Pavlov. Cond. change in total contacts	2.0	2.2	4.2	-2.1	-0.9	1.3
Pavlov. Cond. index score	1.8	2.3	5.1	-2.3	-1.0	0.8
Pavlov. Cond. latency score	1.6	2.0	4.6	-2.1	-0.9	0.7
Pavlov. Cond. lever contacts	0.6	0.7	1.6	-1.3	-0.5	0.4
Pavlov. Cond. magazine entry number	0.9	1.2	2.5	1.6	0.7	-0.8
Pavlov. Cond. intertrial magazine entries	1.2	1.4	4.2	2.1	0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	4.9	-2.2	-0.9	0.8
Pavlov. Cond. response bias	0.6	0.8	1.4	-1.2	-0.6	0.8
Pavlov. Cond. lever latency	0.8	1.2	3.0	-1.7	-0.6	0.5
Pavlov. Cond. magazine entry latency	1.1	1.6	3.5	1.9	0.9	-0.6
Pavlov. Cond. change in total contacts	0.4	1.0	1.4	-1.1	-0.7	1.2
Pavlov. Cond. index score	0.6	1.0	2.4	1.5	0.7	-0.4
Pavlov. Cond. latency score	0.6	0.9	2.3	1.5	0.6	-0.5
Pavlov. Cond. lever contacts	1.0	1.4	3.3	1.8	0.8	-0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	-1.0	-0.6	0.0
Pavlov. Cond. intertrial magazine entries	0.4	1.0	1.2	1.1	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.7	1.6	1.3	0.5	-0.3
Pavlov. Cond. response bias	1.0	1.4	3.2	1.8	0.9	-0.3
Time in closed arm before self-admin	1.3	2.2	3.4	-1.8	-1.2	1.3
Time in closed arm after self-admin	1.6	1.9	2.3	-1.5	-1.3	1.2
Time in open arm before self-admin	0.7	0.8	1.5	-0.4	-1.2	0.8
Time in open arm after self-admin	0.2	0.2	0.5	0.7	0.3	0.1
Bone: periosteal estimation	1.0	2.3	4.6	-2.1	1.4	-0.6
Bone: periosteal perimeter	1.2	2.4	6.7	-2.6	0.3	0.6
Bone: post-yield work	0.5	0.9	1.5	-1.2	1.0	-0.3
Progressive ratio test 1 active lever presses	0.9	1.5	3.5	1.9	-0.7	0.7
Progressive ratio test 1 breakpoint	0.9	1.6	3.8	2.0	-0.6	0.7
Progressive ratio test 1 inactive lever presses	0.1	0.4	0.8	0.1	-0.9	0.5
Progressive ratio test 2 active lever presses	0.2	0.3	0.5	0.5	-0.7	0.5
Progressive ratio test 2 breakpoint	0.3	0.4	0.7	0.3	-0.9	0.6
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.9	0.9	0.1	-0.3
Incentive Sensitization - Responses	0.1	0.4	0.9	-1.0	-0.3	0.3
Incentive Sensitization - Breakpoint	0.2	0.5	1.1	-1.0	-0.5	0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.1	-0.5	0.3
Progressive ratio	0.1	0.4	0.5	0.7	-0.7	0.3
Food seeking constrained by brief footshock	0.5	0.6	1.3	1.1	-0.4	-0.5
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.1	0.4	-0.5
Retroperitoneal fat weight	1.9	8.3	13.8	3.7	3.0	-1.5
Reaction time number correct	0.4	1.4	2.9	-0.0	1.7	-1.1
Reaction time mean minus median	0.1	0.7	1.5	0.7	-1.2	0.1
Reaction time mean minus median AUC	0.1	0.5	1.4	0.3	-1.2	0.4
Reaction time num false alarms	0.3	0.6	0.6	0.7	-0.7	0.8
Reaction time num false alarms AUC	0.3	0.7	0.9	0.7	-1.0	0.8
Reaction time trials correct on left	0.4	1.4	2.9	-0.0	1.7	-1.1
Reaction time trials on left	0.4	1.3	2.8	0.0	1.7	-1.1
Reaction time mean	0.1	0.3	0.8	0.0	-0.9	0.4
Reaction time mean AUC	0.1	0.2	0.5	-0.1	-0.7	0.4
Median of all reaction times	0.1	0.1	0.2	-0.2	-0.5	0.4
Reaction time omissions	0.7	1.1	2.0	1.4	-1.1	-0.4
Reaction time false alarm rate	1.3	1.8	3.3	0.2	-1.8	1.4
Reaction time premature initiation rate	1.0	1.6	3.0	1.7	0.6	-1.2
Reaction time premature initiations	0.9	2.6	3.1	1.6	1.5	-1.8
Std. dev. reaction times	0.3	1.0	2.3	0.6	-1.5	0.6
Reaction time trials completed	0.4	1.3	2.8	0.0	1.7	-1.1
Reaction time trials AUC	0.4	1.3	2.8	-0.2	1.7	-1.0
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.3	0.2	0.5
Run reversals in cocaine runway, males	2.3	2.5	3.8	-1.3	-2.0	1.4
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.2	-0.5	0.1
Latency to leave start box in cocaine runway, F	0.5	0.6	1.3	0.1	-1.2	0.7
Latency to leave start box in cocaine runway, M	0.5	0.5	0.7	-0.5	0.6	-0.9
Std. dev. time between licks in bursts	0.7	1.3	2.8	1.7	0.5	-1.0
Total sessions with >9 infusions	0.4	0.5	0.9	0.8	-0.9	0.2
Short access day 1 total inactive lever presses	0.2	0.3	0.8	0.9	-0.4	-0.1
Short access day 10 total inactive lever presses	0.0	0.2	0.3	-0.3	-0.1	-0.6
Short access day 1 total infusions	0.2	0.5	1.0	1.0	-0.0	-0.7
Short access day 10 total infusions	0.3	0.4	1.0	0.5	-1.0	0.1
Short access total infusions	0.6	0.8	2.0	1.4	-0.4	-0.6
Short access day 1 locomotion	0.1	0.1	0.2	0.3	-0.4	0.2
Short access day 10 total locomotion	0.0	0.2	0.4	0.2	-0.6	0.3
Short access total locomotion	0.2	0.3	0.5	0.6	-0.7	0.3
One hour access (0.3 mA shock)	0.2	0.2	0.5	-0.7	-0.3	-0.1
Compulsive drug intake	0.4	0.5	0.8	-0.7	-0.6	0.9
One hour access (shock baseline)	0.1	0.2	0.5	-0.5	0.1	-0.7
Social response proportion	1.9	2.4	3.3	1.2	1.5	-1.8
Social responses	0.5	0.6	1.1	1.0	-0.6	-0.6
Social time	1.7	2.7	5.1	0.7	1.6	-2.3
Soleus weight	0.1	0.4	0.8	-0.5	0.9	-0.3
Bone: stiffness	2.1	3.8	10.4	-3.2	0.7	0.6
Tibialis anterior weight	9.8	33.6	43.8	-6.6	-4.7	5.9
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.8	0.4	-0.6	-0.9
Time to tail flick, vehicle, after self-admin	0.2	0.5	0.7	-0.8	-0.6	0.6
Time to tail flick, test, before self-admin	0.6	0.7	1.1	-0.5	-1.0	0.9
Time to tail flick, test, after self-admin	0.3	0.3	0.7	-0.9	-0.3	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.2	-0.3	0.4	0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.2	0.4	-0.6
Tibia length	0.6	1.5	3.5	-1.0	1.9	-0.3
Ambulatory time before self-admin	0.2	0.5	1.2	1.1	-0.2	-0.4
Ambulatory time after self-admin	1.9	3.0	4.6	2.1	1.4	-1.6
Bone: tissue strength	0.8	0.9	1.3	-1.1	-0.3	1.2
Total heroin consumption	0.3	0.3	0.8	0.1	0.9	-0.5
Bone: trabecular number	1.1	2.0	3.8	-0.4	1.9	-1.4
Bone: trabecular spacing	0.6	0.8	1.5	-0.1	-1.2	1.0
Bone: trabecular thickness	0.2	0.3	0.8	-0.9	-0.2	0.3
Bone: trabecular tissue density	2.9	5.0	7.0	-1.8	-2.2	2.6
Water consumed over 24 hours	0.4	0.9	1.7	0.7	1.3	-0.6
Number of responses in last shaping day	0.5	0.7	1.7	-0.3	-0.5	1.3