Hub : Genes

Wdr81

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Wdr81 0.06 0.05 4.0e-03 0.01 0.04 0.01 0.03 1.1e-01 5.0e-03 5.6e-02 1.3e-02
2 Brain gene expression Wdr81 0.04 0.03 2.9e-04 0 0.03 0.02 0.01 2.6e-01 1.5e-03 9.6e-03 2.5e-02
3 PL gene expression Wdr81 0.19 0.11 6.8e-13 0.11 0.12 0.1 0.11 4.8e-12 9.9e-13 3.5e-11 7.9e-12
4 pVTA gene expression Wdr81 0.05 0.04 1.0e-03 0.02 0.03 0.02 0.02 1.1e-02 2.6e-03 8.2e-03 7.4e-03
5 IC gene expression Wdr81 0.17 0.1 2.7e-06 0.15 0.13 0.14 0.15 7.8e-07 4.1e-06 2.0e-06 5.6e-07
6 Liver mRNA stability Wdr81 0.04 0.03 2.2e-04 0.03 0.03 0.02 0.02 4.6e-04 6.1e-04 1.4e-03 9.2e-04
7 NAcc gene expression Wdr81 0.05 0.03 2.2e-07 0.04 0.04 0.04 0.04 3.1e-07 9.1e-07 6.5e-07 1.0e-06
8 IL gene expression Wdr81 0.33 0.16 7.9e-06 0.23 0.21 0.17 0.21 2.8e-06 1.0e-05 6.0e-05 9.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density3.35.68.5-2.9-2.9-2.4-2.2-2.02.1-2.0-2.2
Area under the delay curve0.81.01.71.21.30.71.00.9-0.90.90.8
BMI with tail0.72.33.8-1.9-1.9-1.5-1.4-1.31.3-1.4-1.3
BMI without tail2.16.47.5-2.4-2.3-2.7-2.5-2.62.6-2.5-2.4
Body weight3.314.518.9-3.4-3.2-4.3-3.8-4.03.9-3.9-3.9
Weight adjusted by age0.10.10.3-0.5-0.5-0.2-0.1-0.00.1-0.1-0.1
Bone surface2.13.96.8-2.6-2.5-2.1-1.7-1.61.6-1.6-1.8
Bone volume2.34.07.1-2.7-2.6-2.2-1.7-1.51.7-1.6-1.8
Breakpoint value in progressive ratio session1.92.32.8-1.4-1.4-1.7-1.5-1.51.5-1.5-1.5
Number of licking bursts0.30.50.90.80.90.20.80.6-0.60.60.9
Context. condit. distance diff. score1.31.52.1-1.4-1.5-1.0-1.3-1.11.1-1.2-1.2
Locomotion velocity, session 14.14.45.1-2.2-2.3-2.0-2.2-2.02.0-2.0-2.1
Locomotion distance, session 10.20.30.6-0.8-0.8-0.7-0.4-0.40.4-0.4-0.4
Locomotion velocity, session 20.60.71.1-1.1-1.1-0.9-0.8-0.80.7-0.7-0.8
Locomotion distance, session 20.71.02.0-1.4-1.4-1.1-0.8-0.80.8-0.8-0.8
Locomotion velocity, session 32.12.44.92.12.21.11.51.3-1.31.21.2
Locomotion distance, session 30.20.20.30.30.30.30.50.5-0.50.40.5
Stereotopy head waving bouts, day 30.20.20.5-0.2-0.2-0.5-0.5-0.50.4-0.7-0.5
Stereotopy head waving duration, day 30.20.30.50.60.60.20.70.5-0.60.40.5
Locomotion velocity, session 70.20.30.7-0.8-0.9-0.3-0.4-0.40.3-0.3-0.4
Locomotion distance, session 70.50.71.6-1.2-1.3-0.5-0.8-0.60.6-0.7-0.6
Stereotopy head waving bouts, day 71.11.22.0-1.2-1.1-1.4-0.9-1.01.0-1.2-1.0
Stereotopy head waving duration, day 71.01.22.0-1.3-1.2-1.4-0.8-0.90.9-1.1-0.9
Locomotion velocity, session 80.10.10.3-0.6-0.6-0.3-0.3-0.20.2-0.1-0.2
Locomotion distance, session 82.43.44.4-2.1-2.1-1.9-1.8-1.71.7-1.7-1.7
Degree of sensitization distance1.41.41.8-1.3-1.3-1.0-1.3-1.21.2-1.2-1.2
Degree of sensitization stereotypy1.51.62.2-1.4-1.3-1.5-1.1-1.21.2-1.2-1.1
Conditioned locomotion0.60.71.00.80.81.00.81.0-0.90.70.8
Cocaine response after cond. corrected0.30.30.5-0.4-0.5-0.4-0.7-0.60.6-0.7-0.5
Cocaine response after cond. not corrected0.70.81.0-0.8-0.9-0.8-1.0-0.90.9-0.9-0.9
Cocaine response before conditioning0.81.01.6-1.2-1.1-1.3-0.8-0.90.9-0.6-0.9
Saline control response0.10.10.3-0.5-0.4-0.50.1-0.1-0.00.2-0.1
Bone: connectivity density3.96.210.1-3.2-3.1-2.4-2.3-2.02.1-2.1-2.3
Bone: cortical apparent density0.91.31.71.00.91.31.11.2-1.21.31.1
Bone: cortical area0.91.42.51.61.61.21.01.0-1.01.01.0
Bone: cortical porosity0.20.30.3-0.5-0.5-0.5-0.5-0.50.5-0.4-0.6
Bone: cortical porosity0.00.00.1-0.1-0.1-0.2-0.2-0.20.2-0.1-0.2
Bone: cortical thickness2.13.47.32.72.71.71.51.4-1.41.51.3
Bone: cortical thickness0.10.10.40.70.70.1-0.1-0.00.1-0.1-0.2
Bone: cortical tissue density0.60.91.20.80.71.10.91.0-1.01.10.9
Condit. Reinf. active minus inactive responses0.00.00.10.20.3-0.2-0.1-0.10.1-0.2-0.1
Condit. Reinf. active-inactive response ratio0.20.20.70.80.9-0.1-0.1-0.20.2-0.3-0.1
Condit. Reinf. active responses0.10.10.2-0.4-0.4-0.2-0.3-0.20.2-0.3-0.2
Condit. Reinf. inactive responses0.20.30.9-0.9-1.00.20.20.3-0.30.30.3
Incentive salience index mean0.10.20.3-0.1-0.1-0.4-0.5-0.50.5-0.5-0.5
Condit. Reinf. lever presses1.31.82.2-1.1-1.2-1.2-1.5-1.51.4-1.4-1.4
Condit. Reinf. active minus inactive responses0.20.20.4-0.7-0.7-0.5-0.4-0.40.3-0.3-0.4
Condit. Reinf. active-inactive response ratio0.10.10.2-0.1-0.1-0.2-0.4-0.50.3-0.4-0.3
Condit. Reinf. active responses0.10.20.6-0.7-0.7-0.5-0.0-0.10.10.1-0.2
Condit. Reinf. inactive responses0.20.30.6-0.7-0.6-0.30.60.6-0.40.70.3
Condit. Reinf. lever presses1.01.32.20.80.90.81.41.2-1.31.51.0
Condit. Reinf. lever reinforcers received0.10.10.4-0.6-0.5-0.40.20.1-0.10.3-0.0
Conditioned reinforcement - actives0.30.51.5-1.2-1.2-0.4-0.6-0.40.6-0.5-0.6
Conditioned reinforcement - inactives0.10.10.3-0.5-0.5-0.3-0.3-0.30.2-0.3-0.2
Conditioned locomotion0.50.71.10.80.80.81.01.0-0.70.90.6
Patch foraging indifference point 0 sec0.00.10.2-0.4-0.4-0.2-0.2-0.10.2-0.0-0.3
Patch foraging indifference point AUC0.60.81.10.70.71.00.90.9-1.01.01.0
Delay disc. indifference point, 0s delay0.10.10.3-0.3-0.2-0.5-0.1-0.20.2-0.3-0.3
Delay disc. indifference point, 16s delay0.91.01.71.21.30.71.11.0-1.00.90.8
Delay disc. indifference point, 2s delay0.50.61.11.01.00.40.80.7-0.70.90.6
Delay disc. indifference point, 24s delay0.20.30.40.60.60.40.50.5-0.50.60.4
Delay disc. indifference point, 4s delay0.20.20.50.70.70.20.30.2-0.20.40.0
Delay disc. indifference point, 8s delay0.30.40.80.90.90.40.60.5-0.50.60.5
Indifference point function ln k0.50.91.2-1.1-1.1-0.8-0.9-0.81.0-0.7-1.0
Indifference point function log k0.50.91.2-1.1-1.1-0.8-0.9-0.81.0-0.7-1.0
Patch foraging total patch changes 0 sec0.00.10.2-0.5-0.5-0.2-0.2-0.10.2-0.0-0.2
Patch foraging total patch changes 12 sec0.10.10.30.60.60.30.30.3-0.40.30.2
Patch foraging total patch changes 18 sec0.10.10.50.60.70.00.30.2-0.20.30.2
Patch foraging total patch changes 24 sec0.40.60.80.90.90.70.70.7-0.70.80.8
Patch foraging total patch changes 6 sec0.50.71.20.60.60.71.00.9-0.91.10.9
Patch foraging time to switch 0 sec0.10.20.30.40.4-0.6-0.4-0.50.6-0.4-0.5
Patch foraging water rate 0 sec0.20.50.70.20.10.70.80.8-0.80.80.8
Patch foraging water rate 12 sec0.00.00.1-0.2-0.1-0.3-0.1-0.20.2-0.1-0.2
Patch foraging water rate 18 sec0.81.22.6-1.6-1.6-1.2-0.8-0.80.8-0.9-0.7
Patch foraging water rate 24 sec0.00.10.1-0.1-0.10.10.30.3-0.30.30.3
Patch foraging water rate 6 sec0.60.91.10.80.81.00.91.0-0.91.10.9
Seeking ratio, delayed vs. immediate footshock1.82.22.71.41.51.11.61.5-1.51.61.5
Distance traveled before self-admin3.24.25.82.32.41.72.11.9-2.01.92.0
Distance traveled after self-admin0.30.40.60.70.80.50.60.5-0.50.50.6
Extensor digitorum longus weight1.76.714.8-3.8-3.8-2.3-2.1-1.91.9-2.0-1.9
Bone: elastic displacement0.91.11.61.01.01.11.01.1-1.01.30.8
Bone: elastic work2.33.05.42.32.31.51.51.5-1.41.61.2
Bone: endosteal estimation0.00.10.2-0.4-0.4-0.2-0.1-0.10.0-0.10.0
Bone: endosteal perimeter0.10.10.5-0.7-0.70.00.00.1-0.20.10.2
Epididymis fat weight7.927.034.4-5.9-5.7-5.5-5.0-5.04.8-4.7-4.9
Delta time in closed arm before/after self-admin1.81.62.21.21.21.21.41.3-1.21.31.5
Delta time in open arm before/after self-admin1.51.51.9-1.3-1.3-1.3-1.2-1.21.2-1.1-1.4
Diff in mean of infusions in LGA sessions1.72.12.4-1.5-1.5-1.2-1.6-1.51.5-1.4-1.4
Delay discount exponential model param0.70.71.4-1.1-1.2-0.6-0.8-0.80.8-0.8-0.6
Extinction: sum of active levers before priming0.90.92.1-1.4-1.4-0.7-0.8-0.70.8-0.5-0.9
Active lever presses in extinction session 61.21.22.2-1.5-1.5-1.0-1.0-0.91.0-0.9-1.0
Bone: final force0.10.20.20.40.4-0.5-0.3-0.40.3-0.5-0.4
Bone: final moment0.10.10.20.40.5-0.3-0.2-0.30.2-0.4-0.3
Food consumed during 24 hour testing period0.20.30.5-0.6-0.7-0.3-0.6-0.50.5-0.5-0.6
Glucose3.14.97.02.62.62.12.12.0-2.02.11.9
Heart weight2.23.43.7-1.8-1.8-1.9-1.8-1.81.9-1.9-1.8
Delay discount hyperbolic model param0.70.81.5-1.2-1.2-0.6-0.8-0.70.7-0.8-0.6
Intermittent access intake day 1-15 change0.81.62.20.90.91.31.31.2-1.51.31.5
Intermittent access intake escalation0.81.72.40.90.91.41.31.3-1.51.31.5
Intermittent access intake escalation 21.82.12.81.11.11.51.51.4-1.71.41.7
Intermitt. access day 1 inactive lever presses1.14.25.22.01.92.32.02.0-2.21.92.2
Intermitt. access day 15 inactive lever presses2.34.65.72.02.02.42.22.3-2.02.22.1
Intermitt. access escalation Index1.52.13.6-1.0-1.0-1.4-1.6-1.51.6-1.9-1.6
Intermittent access day 1 total infusions0.00.00.10.10.2-0.10.20.2-0.10.10.0
Intermittent access day 15 total infusions0.20.40.60.20.20.60.70.7-0.80.60.7
Intermittent access terminal intake (last 3 days)0.00.10.3-0.5-0.5-0.1-0.00.1-0.1-0.00.0
Intermittent access total infusions0.20.20.40.10.20.40.50.6-0.50.40.5
Intermittent access day 1 locomotion0.10.10.30.50.50.00.30.3-0.20.30.1
Intermittent access day 15 total locomotion0.30.60.80.70.80.70.80.9-0.80.70.8
Intermittent access total locomotion0.20.30.30.40.40.40.60.6-0.60.60.5
Intermittent access standard deviation1.12.33.10.80.81.71.61.7-1.81.61.8
Left kidney weight0.10.62.51.51.6-0.30.1-0.10.2-0.1-0.2
Right kidney weight0.10.60.90.91.0-0.9-0.5-0.80.7-0.7-0.7
Cocaine induced anxiety0.20.30.50.50.40.70.60.6-0.60.50.6
Post-drug Anxiety0.80.91.1-0.8-0.9-0.8-1.1-0.91.0-1.0-1.0
Baseline Anxiety2.02.32.6-1.4-1.5-1.4-1.6-1.61.6-1.5-1.6
Tail length2.49.412.7-2.2-2.1-3.6-3.1-3.43.3-3.2-3.3
Length with tail2.29.412.8-2.0-1.9-3.6-3.2-3.53.3-3.3-3.3
Length without tail1.13.75.7-1.5-1.4-2.4-1.9-2.02.0-1.9-2.1
Times rat made contact with spout0.10.10.40.60.6-0.0-0.0-0.10.1-0.1-0.2
Lifetime Intake0.10.20.30.10.20.40.40.6-0.40.40.4
Liver weight, left8.413.915.7-3.1-3.1-3.8-4.0-3.93.9-3.9-3.9
Liver weight, right6.210.811.9-2.9-2.8-3.4-3.4-3.43.4-3.4-3.4
Locomotor activity0.10.10.2-0.3-0.3-0.5-0.2-0.20.3-0.1-0.3
Locomotor testing distance0.00.00.2-0.2-0.2-0.4-0.1-0.10.1-0.0-0.2
Locomotor testing rearing0.00.00.1-0.4-0.3-0.20.20.1-0.10.3-0.0
Locomotion in novel chamber5.16.58.32.12.12.62.62.7-2.62.92.7
Locomotion in novel chamber post-restriction0.10.10.2-0.1-0.20.30.30.4-0.30.40.3
Fecal boli incidents, locomotor time 10.00.10.1-0.2-0.2-0.3-0.2-0.20.3-0.2-0.1
Change in fecal boli incidents, locomotor task0.00.00.20.40.30.3-0.10.00.00.0-0.1
Time >=10cm from walls, locomotor time 10.00.00.1-0.3-0.40.1-0.2-0.10.1-0.20.1
Bouts of movement, locomotor time 10.00.00.1-0.2-0.30.1-0.3-0.10.2-0.2-0.2
Total resting periods, locomotor time 10.00.00.2-0.1-0.20.4-0.10.1-0.0-0.1-0.0
Rest time, locomotor task time 10.60.71.30.70.61.10.70.9-0.80.80.8
Distance moved, locomotor task time 10.00.00.1-0.3-0.2-0.2-0.1-0.20.1-0.1-0.2
Vertical activity count, locomotor time 10.20.40.7-0.8-0.8-0.7-0.5-0.50.5-0.5-0.5
Time >=10cm from walls, locomotor time 20.20.30.50.70.70.60.40.5-0.50.30.6
Bouts of movement, locomotor time 20.00.00.00.20.20.10.00.1-0.10.0-0.1
Total resting periods, locomotor time 20.00.00.1-0.2-0.2-0.1-0.2-0.10.1-0.2-0.3
Rest time, locomotor task time 20.00.00.1-0.2-0.30.2-0.10.10.1-0.00.2
Distance moved, locomotor task time 20.50.60.80.60.70.60.90.8-0.80.90.7
Vertical activity count, locomotor time 20.10.10.30.50.50.20.40.3-0.30.30.2
Light reinforcement 10.00.10.3-0.2-0.0-0.60.1-0.10.10.10.1
Light reinforcement 20.50.82.31.41.50.30.90.6-0.60.70.6
Bone: marrow area0.00.00.2-0.4-0.4-0.2-0.1-0.10.0-0.10.0
Bone: maximum diameter0.20.40.70.30.30.80.60.6-0.70.70.8
Bone: maximum force0.10.10.50.70.7-0.10.0-0.20.0-0.1-0.1
Bone: maximum moment0.10.10.60.70.80.10.20.0-0.20.00.1
Mean time between licks in bursts0.40.91.4-0.7-0.7-1.2-1.0-1.01.0-1.1-1.0
Mean num. licks in bursts0.30.51.2-0.4-0.5-0.2-0.9-0.70.7-0.7-1.1
Cd content in liver0.10.10.2-0.3-0.30.40.20.3-0.30.40.3
Co content in liver0.00.00.10.30.30.30.10.1-0.10.20.2
Cu content in liver0.50.60.91.00.90.80.70.7-0.70.60.7
Fe content in liver0.70.91.1-0.7-0.7-1.1-1.0-1.01.0-1.0-1.0
K content in liver0.60.61.2-0.3-0.2-1.1-0.7-0.90.9-0.8-0.8
Mg content in liver0.00.00.0-0.2-0.1-0.10.10.0-0.00.10.1
Mn content in liver0.00.10.1-0.4-0.40.20.10.1-0.10.20.1
Na content in liver0.70.82.01.41.40.60.80.6-0.60.60.6
Rb content in liver0.91.12.8-1.7-1.7-0.9-0.8-0.70.7-0.6-0.7
Se content in liver0.20.30.50.70.70.40.40.4-0.40.40.4
Sr content in liver0.20.20.7-0.8-0.8-0.1-0.4-0.20.2-0.2-0.3
Zn content in liver0.60.60.9-0.7-0.7-0.5-0.9-0.80.8-0.8-0.8
Bone: minimum diameter0.10.20.60.80.80.20.20.1-0.20.10.1
Time in familiar zone, hab. session 10.20.20.3-0.3-0.30.50.40.5-0.40.60.5
Time in novel zone, hab. session 10.10.10.20.30.4-0.4-0.3-0.30.4-0.5-0.4
Total zone transitions, hab. session 10.10.20.6-0.8-0.6-0.60.30.2-0.20.30.2
Total locomotion distance, hab. session 10.10.10.4-0.6-0.5-0.6-0.0-0.10.1-0.1-0.2
Locomotion velocity, hab. session 10.10.10.3-0.6-0.5-0.50.1-0.00.00.0-0.1
Time in familiar zone, hab. session 20.30.31.0-1.0-0.9-0.6-0.3-0.30.4-0.3-0.3
Time in novel zone, hab. session 21.01.02.71.61.60.90.70.6-0.60.70.6
Total zone transitions, hab. session 20.50.71.5-1.1-0.9-1.2-0.5-0.70.6-0.6-0.7
Total locomotion distance, hab. session 20.10.20.5-0.4-0.3-0.7-0.3-0.40.3-0.4-0.4
Locomotion velocity, hab. session 20.10.10.3-0.3-0.2-0.6-0.2-0.30.3-0.3-0.3
Novel to familiar place preference ratio0.50.51.00.50.51.00.70.8-0.80.60.7
Novelty place preference0.10.10.40.30.20.60.20.4-0.30.20.3
Time in novel zone, NPP test0.00.00.1-0.0-0.10.30.00.1-0.1-0.00.1
Total zone transitions, NPP test0.20.20.7-0.8-0.6-0.90.1-0.10.0-0.1-0.1
Total locomotion distance, NPP test0.10.20.40.00.1-0.10.70.5-0.50.50.5
Locomotion velocity, NPP test0.50.81.20.50.60.51.11.0-1.01.00.9
Intraocular pressure1.31.92.60.80.91.31.61.4-1.61.61.6
Delta distance traveled before/after self-admin2.52.63.3-1.8-1.8-1.3-1.7-1.51.6-1.5-1.6
Delta ambulatory time before/after self-admin1.82.23.0-1.7-1.7-1.1-1.6-1.41.5-1.4-1.5
Parametrial fat weight8.820.824.8-5.0-4.9-4.7-4.4-4.34.4-4.2-4.4
Pavlov. Cond. lever latency0.20.20.30.10.10.50.50.6-0.60.50.5
Pavlov. Cond. magazine entry latency0.70.91.3-0.7-0.8-0.7-1.1-1.01.0-1.0-1.0
Pavlov. Cond. change in total contacts0.20.30.60.70.70.50.40.3-0.30.50.4
Pavlov. Cond. index score0.81.01.4-0.7-0.8-1.0-1.2-1.21.1-1.0-1.1
Pavlov. Cond. latency score1.01.31.7-0.7-0.8-1.1-1.3-1.31.3-1.2-1.2
Pavlov. Cond. lever contacts0.20.20.3-0.1-0.1-0.4-0.5-0.60.5-0.4-0.5
Pavlov. Cond. magazine entry number0.20.20.40.40.50.30.60.5-0.50.40.5
Pavlov. Cond. intertrial magazine entries0.30.40.90.20.30.10.90.7-0.80.70.8
Pavlov. Cond. lever-magazine prob. diff.0.60.71.0-0.6-0.7-0.8-1.0-1.01.0-0.8-0.9
Pavlov. Cond. response bias0.50.60.8-0.7-0.7-0.7-0.9-0.90.8-0.8-0.8
Pavlov. Cond. lever latency1.41.92.6-1.5-1.6-1.0-1.5-1.31.4-1.4-1.1
Pavlov. Cond. magazine entry latency0.30.31.10.91.0-0.10.50.2-0.30.50.4
Pavlov. Cond. change in total contacts0.61.01.71.21.30.61.00.8-0.90.90.9
Pavlov. Cond. index score1.72.23.41.71.81.01.61.4-1.41.51.3
Pavlov. Cond. latency score2.12.84.01.92.01.21.81.5-1.61.71.5
Pavlov. Cond. lever contacts0.50.71.31.01.10.40.90.7-0.80.90.6
Pavlov. Cond. magazine entry number0.50.61.5-1.1-1.2-0.2-0.8-0.50.6-0.6-0.6
Pavlov. Cond. intertrial magazine entries0.71.12.4-1.5-1.5-0.8-0.9-0.80.8-1.0-0.7
Pavlov. Cond. lever-magazine prob. diff.1.62.13.11.71.81.01.61.3-1.41.51.3
Pavlov. Cond. response bias0.70.91.81.31.30.51.00.8-0.80.90.7
Time in closed arm before self-admin2.63.33.5-1.8-1.8-1.8-1.9-1.81.8-1.9-1.9
Time in closed arm after self-admin0.20.20.40.60.60.40.40.4-0.30.30.4
Time in open arm before self-admin3.74.15.32.32.32.01.91.8-1.81.92.0
Time in open arm after self-admin0.80.81.00.90.91.00.90.9-0.91.00.8
Bone: periosteal estimation0.10.20.30.60.60.30.40.3-0.40.30.4
Bone: periosteal perimeter0.20.30.40.50.40.60.50.5-0.60.50.6
Bone: post-yield work0.71.11.3-1.0-1.0-1.1-1.0-1.21.0-1.2-0.8
Progressive ratio test 1 active lever presses0.20.30.40.50.50.50.60.7-0.60.50.5
Progressive ratio test 1 breakpoint0.20.30.50.40.50.50.70.7-0.60.50.5
Progressive ratio test 1 inactive lever presses2.13.03.41.81.71.81.71.7-1.81.71.7
Progressive ratio test 2 active lever presses0.20.30.5-0.0-0.00.60.60.7-0.60.50.6
Progressive ratio test 2 breakpoint0.20.20.4-0.1-0.10.50.50.7-0.60.40.6
Progressive ratio test 2 inactive lever presses0.81.31.60.80.81.21.21.3-1.21.21.2
Incentive Sensitization - Responses0.10.10.2-0.4-0.40.30.20.3-0.40.20.4
Incentive Sensitization - Breakpoint0.10.10.2-0.4-0.40.30.20.3-0.40.10.4
Sum of active levers in priming session hrs 5-63.83.53.8-1.9-1.9-1.7-1.9-1.91.9-1.8-1.9
Progressive ratio0.40.61.00.50.50.60.90.8-0.81.00.9
Food seeking constrained by brief footshock0.10.10.10.30.30.30.30.3-0.30.20.3
Seeking ratio, punishment vs. effort0.00.10.20.40.40.0-0.1-0.20.1-0.3-0.1
Retroperitoneal fat weight0.21.02.0-1.0-0.9-1.4-0.8-1.00.8-0.9-0.9
Reaction time number correct0.10.20.3-0.4-0.4-0.5-0.3-0.40.5-0.4-0.3
Reaction time mean minus median0.20.50.70.40.40.80.70.7-0.70.70.8
Reaction time mean minus median AUC0.00.10.2-0.4-0.40.30.20.3-0.20.30.4
Reaction time num false alarms0.71.01.60.50.60.81.31.2-1.21.21.1
Reaction time num false alarms AUC0.71.01.60.50.60.81.21.2-1.21.11.1
Reaction time trials correct on left0.10.20.3-0.4-0.4-0.5-0.3-0.40.5-0.4-0.3
Reaction time trials on left0.10.10.2-0.4-0.4-0.5-0.3-0.30.4-0.3-0.3
Reaction time mean0.10.10.30.30.30.50.20.3-0.20.30.3
Reaction time mean AUC0.30.50.90.70.60.90.60.7-0.60.70.7
Median of all reaction times0.00.10.10.30.30.40.10.2-0.10.20.1
Reaction time omissions0.00.00.1-0.3-0.3-0.1-0.2-0.10.2-0.0-0.2
Reaction time false alarm rate0.60.91.30.50.50.91.11.1-1.11.01.0
Reaction time premature initiation rate0.20.20.5-0.7-0.7-0.2-0.4-0.30.4-0.4-0.4
Reaction time premature initiations0.20.30.6-0.8-0.8-0.4-0.4-0.40.5-0.4-0.4
Std. dev. reaction times0.20.40.70.30.30.80.60.7-0.60.60.7
Reaction time trials completed0.10.10.2-0.4-0.4-0.5-0.3-0.30.4-0.3-0.3
Reaction time trials AUC0.10.10.2-0.4-0.3-0.4-0.2-0.30.4-0.3-0.2
Run reversals in cocaine runway, females0.80.81.10.60.60.81.01.0-0.91.01.1
Run reversals in cocaine runway, males0.10.10.2-0.1-0.20.40.40.4-0.50.30.5
Latency to leave start box in cocaine runway0.00.00.10.20.30.00.10.10.00.10.1
Latency to leave start box in cocaine runway, F0.20.20.4-0.2-0.2-0.6-0.5-0.50.6-0.5-0.5
Latency to leave start box in cocaine runway, M0.20.20.20.40.40.40.40.4-0.40.40.4
Std. dev. time between licks in bursts0.00.10.2-0.4-0.4-0.3-0.1-0.20.1-0.1-0.1
Total sessions with >9 infusions0.20.20.40.20.20.60.50.7-0.50.60.4
Short access day 1 total inactive lever presses0.00.00.1-0.3-0.3-0.1-0.3-0.30.1-0.3-0.1
Short access day 10 total inactive lever presses0.41.01.31.11.11.10.90.9-1.01.11.0
Short access day 1 total infusions1.11.41.81.01.01.41.21.3-1.21.31.1
Short access day 10 total infusions0.50.71.00.60.60.80.91.0-0.90.80.8
Short access total infusions0.81.11.40.90.91.11.11.2-1.01.11.0
Short access day 1 locomotion1.82.22.61.51.61.51.61.5-1.41.61.3
Short access day 10 total locomotion0.91.61.81.31.31.31.31.2-1.21.31.2
Short access total locomotion2.83.33.51.81.81.91.91.9-1.81.91.7
One hour access (0.3 mA shock)0.10.10.3-0.6-0.6-0.0-0.00.1-0.0-0.1-0.0
Compulsive drug intake1.41.62.0-1.1-1.1-1.3-1.4-1.31.4-1.2-1.4
One hour access (shock baseline)0.20.40.50.40.40.60.70.7-0.70.50.7
Social response proportion4.14.65.4-1.9-1.9-2.1-2.3-2.22.3-2.0-2.3
Social responses2.43.13.3-1.8-1.8-1.8-1.8-1.71.8-1.6-1.8
Social time2.73.74.3-2.1-2.0-1.9-1.9-1.81.9-1.9-1.9
Soleus weight4.713.815.0-3.8-3.8-3.9-3.7-3.73.5-3.8-3.6
Bone: stiffness1.72.73.4-1.4-1.4-1.8-1.7-1.81.6-1.8-1.5
Tibialis anterior weight4.415.027.2-5.2-5.2-3.6-3.4-3.23.2-3.2-3.2
Time to tail flick, vehicle, before self-admin4.64.87.5-2.7-2.7-2.0-2.1-2.02.0-2.0-1.9
Time to tail flick, vehicle, after self-admin0.20.30.4-0.6-0.6-0.5-0.4-0.40.4-0.4-0.4
Time to tail flick, test, before self-admin1.11.11.2-1.1-1.1-1.1-1.1-1.11.0-1.1-1.0
Time to tail flick, test, after self-admin0.00.00.10.10.1-0.1-0.2-0.20.2-0.2-0.3
Delta time to tail flick, vehicle, before/after SA1.61.51.71.31.31.31.21.2-1.21.21.2
Delta time to tail flick, test, before/after SA0.80.81.10.80.81.10.91.0-0.91.00.8
Tibia length0.51.52.2-0.4-0.4-1.3-1.4-1.51.4-1.3-1.4
Ambulatory time before self-admin2.33.45.92.42.41.41.81.6-1.71.61.7
Ambulatory time after self-admin0.10.10.20.20.2-0.3-0.3-0.40.4-0.4-0.4
Bone: tissue strength0.80.81.91.31.40.60.80.7-0.80.70.7
Total heroin consumption5.05.87.0-2.6-2.6-2.4-2.4-2.32.3-2.2-2.4
Bone: trabecular number3.25.28.4-2.9-2.9-2.3-2.1-1.92.0-1.8-2.1
Bone: trabecular spacing0.70.91.11.11.01.00.90.8-0.80.81.0
Bone: trabecular thickness0.40.50.7-0.8-0.8-0.8-0.6-0.50.6-0.6-0.7
Bone: trabecular tissue density1.62.33.51.91.91.51.41.3-1.41.41.4
Water consumed over 24 hours0.20.20.40.10.1-0.4-0.5-0.50.6-0.5-0.7
Number of responses in last shaping day2.42.63.21.61.61.61.71.6-1.61.81.5