Wdr81

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Wdr81	0.06	0.05	4.0e-03	0.01	0.04	0.01	0.03	1.1e-01	5.0e-03	5.6e-02	1.2e-02
2	Brain	gene expression	Wdr81	0.04	0.03	2.9e-04	0	0.03	0.02	0.01	2.6e-01	1.5e-03	9.6e-03	2.8e-02
3	PL	gene expression	Wdr81	0.19	0.11	6.8e-13	0.11	0.12	0.1	0.11	4.8e-12	9.9e-13	3.4e-11	7.9e-12
4	pVTA	gene expression	Wdr81	0.05	0.04	1.0e-03	0.02	0.03	0.02	0.02	1.1e-02	2.6e-03	8.2e-03	7.2e-03
5	IC	gene expression	Wdr81	0.17	0.1	2.7e-06	0.15	0.13	0.14	0.15	7.8e-07	4.1e-06	2.0e-06	5.7e-07
6	Liver	mRNA stability	Wdr81	0.04	0.03	2.2e-04	0.03	0.03	0.02	0.02	4.6e-04	6.1e-04	1.4e-03	9.2e-04
7	NAcc	gene expression	Wdr81	0.05	0.03	2.2e-07	0.04	0.04	0.04	0.04	3.1e-07	9.1e-07	6.5e-07	1.0e-06
8	IL	gene expression	Wdr81	0.33	0.16	7.9e-06	0.23	0.21	0.17	0.21	2.8e-06	1.0e-05	6.0e-05	9.0e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	3.0	5.6	8.5	-2.9	-2.9	-2.4	-2.2	-2.0	-2.1	2.0	2.2
Area under the delay curve	0.6	1.0	1.7	1.2	1.3	0.7	1.0	0.9	0.9	-0.9	-0.8
BMI with tail	0.7	2.3	3.8	-1.9	-1.9	-1.5	-1.4	-1.3	-1.3	1.4	1.3
BMI without tail	1.2	6.4	7.5	-2.4	-2.3	-2.7	-2.5	-2.6	-2.6	2.5	2.4
Body weight	3.3	14.5	18.9	-3.4	-3.2	-4.3	-3.8	-4.0	-3.9	3.9	3.9
Weight adjusted by age	0.0	0.1	0.3	-0.5	-0.5	-0.2	-0.1	-0.0	-0.1	0.1	0.1
Bone surface	2.0	3.9	6.8	-2.6	-2.5	-2.1	-1.7	-1.6	-1.6	1.6	1.8
Bone volume	2.0	4.0	7.1	-2.7	-2.6	-2.2	-1.7	-1.5	-1.7	1.6	1.8
Breakpoint value in progressive ratio session	1.2	2.3	2.8	-1.4	-1.4	-1.7	-1.5	-1.5	-1.5	1.5	1.5
Number of licking bursts	0.2	0.5	0.9	0.8	0.9	0.2	0.8	0.6	0.6	-0.6	-0.9
Context. condit. distance diff. score	1.3	1.5	2.1	-1.4	-1.5	-1.0	-1.3	-1.1	-1.1	1.2	1.2
Locomotion velocity, session 1	3.9	4.4	5.1	-2.2	-2.3	-2.0	-2.2	-2.0	-2.0	2.0	2.1
Locomotion distance, session 1	0.2	0.3	0.6	-0.8	-0.8	-0.7	-0.4	-0.4	-0.4	0.4	0.4
Locomotion velocity, session 2	0.6	0.7	1.1	-1.1	-1.1	-0.9	-0.8	-0.8	-0.7	0.7	0.8
Locomotion distance, session 2	0.7	1.0	2.0	-1.4	-1.4	-1.1	-0.8	-0.8	-0.8	0.8	0.8
Locomotion velocity, session 3	2.1	2.4	4.9	2.1	2.2	1.1	1.5	1.3	1.3	-1.2	-1.2
Locomotion distance, session 3	0.2	0.2	0.3	0.3	0.3	0.3	0.5	0.5	0.5	-0.4	-0.5
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	-0.2	-0.2	-0.5	-0.5	-0.5	-0.4	0.7	0.5
Stereotopy head waving duration, day 3	0.2	0.3	0.5	0.6	0.6	0.2	0.7	0.5	0.6	-0.4	-0.5
Locomotion velocity, session 7	0.2	0.3	0.7	-0.8	-0.9	-0.3	-0.4	-0.4	-0.3	0.3	0.4
Locomotion distance, session 7	0.5	0.7	1.6	-1.2	-1.3	-0.5	-0.8	-0.6	-0.6	0.7	0.6
Stereotopy head waving bouts, day 7	1.0	1.2	2.0	-1.2	-1.1	-1.4	-0.9	-1.0	-1.0	1.2	1.0
Stereotopy head waving duration, day 7	0.9	1.2	2.0	-1.3	-1.2	-1.4	-0.8	-0.9	-0.9	1.1	0.9
Locomotion velocity, session 8	0.1	0.1	0.3	-0.6	-0.6	-0.3	-0.3	-0.2	-0.2	0.1	0.2
Locomotion distance, session 8	2.3	3.4	4.4	-2.1	-2.1	-1.9	-1.8	-1.7	-1.7	1.7	1.7
Degree of sensitization distance	1.3	1.4	1.8	-1.3	-1.3	-1.0	-1.3	-1.2	-1.2	1.2	1.2
Degree of sensitization stereotypy	1.4	1.6	2.2	-1.4	-1.3	-1.5	-1.1	-1.2	-1.2	1.2	1.1
Conditioned locomotion	0.6	0.7	1.0	0.8	0.8	1.0	0.8	1.0	0.9	-0.7	-0.8
Cocaine response after cond. corrected	0.2	0.3	0.5	-0.4	-0.5	-0.4	-0.7	-0.6	-0.6	0.7	0.5
Cocaine response after cond. not corrected	0.5	0.8	1.0	-0.8	-0.9	-0.8	-1.0	-0.9	-0.9	0.9	0.9
Cocaine response before conditioning	0.8	1.0	1.6	-1.2	-1.1	-1.3	-0.8	-0.9	-0.9	0.6	0.9
Saline control response	0.1	0.1	0.3	-0.5	-0.4	-0.5	0.1	-0.1	0.0	-0.2	0.1
Bone: connectivity density	3.9	6.2	10.1	-3.2	-3.1	-2.4	-2.3	-2.0	-2.1	2.1	2.3
Bone: cortical apparent density	0.8	1.3	1.7	1.0	0.9	1.3	1.1	1.2	1.2	-1.3	-1.1
Bone: cortical area	0.9	1.4	2.5	1.6	1.6	1.2	1.0	1.0	1.0	-1.0	-1.0
Bone: cortical porosity	0.2	0.3	0.3	-0.5	-0.5	-0.5	-0.5	-0.5	-0.5	0.4	0.6
Bone: cortical porosity	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	-0.2	-0.2	0.1	0.2
Bone: cortical thickness	2.1	3.4	7.3	2.7	2.7	1.7	1.5	1.4	1.4	-1.5	-1.3
Bone: cortical thickness	0.1	0.1	0.4	0.7	0.7	0.1	-0.1	-0.0	-0.1	0.1	0.2
Bone: cortical tissue density	0.6	0.9	1.2	0.8	0.7	1.1	0.9	1.0	1.0	-1.1	-0.9
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.2	0.3	-0.2	-0.1	-0.1	-0.1	0.2	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	0.8	0.9	-0.1	-0.1	-0.2	-0.2	0.3	0.1
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.3	-0.2	-0.2	0.3	0.2
Condit. Reinf. inactive responses	0.2	0.3	0.9	-0.9	-1.0	0.2	0.2	0.3	0.3	-0.3	-0.3
Incentive salience index mean	0.1	0.2	0.3	-0.1	-0.1	-0.4	-0.5	-0.5	-0.5	0.5	0.5
Condit. Reinf. lever presses	1.2	1.8	2.2	-1.1	-1.2	-1.2	-1.5	-1.5	-1.4	1.4	1.4
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.7	-0.7	-0.5	-0.4	-0.4	-0.3	0.3	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.1	-0.1	-0.2	-0.4	-0.5	-0.3	0.4	0.3
Condit. Reinf. active responses	0.1	0.2	0.6	-0.7	-0.7	-0.5	-0.0	-0.1	-0.1	-0.1	0.2
Condit. Reinf. inactive responses	0.2	0.3	0.6	-0.7	-0.6	-0.3	0.6	0.6	0.4	-0.7	-0.3
Condit. Reinf. lever presses	0.9	1.3	2.2	0.8	0.9	0.8	1.4	1.2	1.3	-1.5	-1.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.4	-0.6	-0.5	-0.4	0.2	0.1	0.1	-0.3	0.0
Conditioned reinforcement - actives	0.1	0.5	1.5	-1.2	-1.2	-0.4	-0.6	-0.4	-0.6	0.5	0.6
Conditioned reinforcement - inactives	0.0	0.1	0.3	-0.5	-0.5	-0.3	-0.3	-0.3	-0.2	0.3	0.2
Conditioned locomotion	0.5	0.7	1.1	0.8	0.8	0.8	1.0	1.0	0.7	-0.9	-0.6
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.4	-0.4	-0.2	-0.2	-0.1	-0.2	0.0	0.3
Patch foraging indifference point AUC	0.4	0.8	1.1	0.7	0.7	1.0	0.9	0.9	1.0	-1.0	-1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.3	-0.2	-0.5	-0.1	-0.2	-0.2	0.3	0.3
Delay disc. indifference point, 16s delay	0.7	1.0	1.7	1.2	1.3	0.7	1.1	1.0	1.0	-0.9	-0.8
Delay disc. indifference point, 2s delay	0.5	0.6	1.1	1.0	1.0	0.4	0.8	0.7	0.7	-0.9	-0.6
Delay disc. indifference point, 24s delay	0.2	0.3	0.4	0.6	0.6	0.4	0.5	0.5	0.5	-0.6	-0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.7	0.7	0.2	0.3	0.2	0.2	-0.4	-0.0
Delay disc. indifference point, 8s delay	0.2	0.4	0.8	0.9	0.9	0.4	0.6	0.5	0.5	-0.6	-0.5
Indifference point function ln k	0.3	0.9	1.2	-1.1	-1.1	-0.8	-0.9	-0.8	-1.0	0.7	1.0
Indifference point function log k	0.3	0.9	1.2	-1.1	-1.1	-0.8	-0.9	-0.8	-1.0	0.7	1.0
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.5	-0.5	-0.2	-0.2	-0.1	-0.2	0.0	0.2
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	0.6	0.6	0.3	0.3	0.3	0.4	-0.3	-0.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.5	0.6	0.7	0.0	0.3	0.2	0.2	-0.3	-0.2
Patch foraging total patch changes 24 sec	0.2	0.6	0.8	0.9	0.9	0.7	0.7	0.7	0.7	-0.8	-0.8
Patch foraging total patch changes 6 sec	0.4	0.7	1.2	0.6	0.6	0.7	1.0	0.9	0.9	-1.1	-0.9
Patch foraging time to switch 0 sec	0.1	0.2	0.3	0.4	0.4	-0.6	-0.4	-0.5	-0.6	0.4	0.5
Patch foraging water rate 0 sec	0.1	0.5	0.7	0.2	0.1	0.7	0.8	0.8	0.8	-0.8	-0.8
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.1	-0.2	-0.2	0.1	0.2
Patch foraging water rate 18 sec	0.5	1.2	2.6	-1.6	-1.6	-1.2	-0.8	-0.8	-0.8	0.9	0.7
Patch foraging water rate 24 sec	0.0	0.1	0.1	-0.1	-0.1	0.1	0.3	0.3	0.3	-0.3	-0.3
Patch foraging water rate 6 sec	0.6	0.9	1.1	0.8	0.8	1.0	0.9	1.0	0.9	-1.1	-0.9
Seeking ratio, delayed vs. immediate footshock	1.5	2.2	2.7	1.4	1.5	1.1	1.6	1.5	1.5	-1.6	-1.5
Distance traveled before self-admin	1.9	4.2	5.8	2.3	2.4	1.7	2.1	1.9	2.0	-1.9	-2.0
Distance traveled after self-admin	0.2	0.4	0.6	0.7	0.8	0.5	0.6	0.5	0.5	-0.5	-0.6
Extensor digitorum longus weight	1.7	6.7	14.8	-3.8	-3.8	-2.3	-2.1	-1.9	-1.9	2.0	1.9
Bone: elastic displacement	0.9	1.1	1.6	1.0	1.0	1.1	1.0	1.1	1.0	-1.3	-0.8
Bone: elastic work	2.3	3.0	5.4	2.3	2.3	1.5	1.5	1.5	1.4	-1.6	-1.2
Bone: endosteal estimation	0.0	0.1	0.2	-0.4	-0.4	-0.2	-0.1	-0.1	-0.0	0.1	-0.0
Bone: endosteal perimeter	0.1	0.1	0.5	-0.7	-0.7	0.0	0.0	0.1	0.2	-0.1	-0.2
Epididymis fat weight	5.4	27.0	34.4	-5.9	-5.7	-5.5	-5.0	-5.0	-4.8	4.7	4.9
Delta time in closed arm before/after self-admin	1.7	1.6	2.2	1.2	1.2	1.2	1.4	1.3	1.2	-1.3	-1.5
Delta time in open arm before/after self-admin	1.3	1.5	1.9	-1.3	-1.3	-1.3	-1.2	-1.2	-1.2	1.1	1.4
Diff in mean of infusions in LGA sessions	1.2	2.1	2.4	-1.5	-1.5	-1.2	-1.6	-1.5	-1.5	1.4	1.4
Delay discount exponential model param	0.6	0.7	1.4	-1.1	-1.2	-0.6	-0.8	-0.8	-0.8	0.8	0.6
Extinction: sum of active levers before priming	0.6	0.9	2.1	-1.4	-1.4	-0.7	-0.8	-0.7	-0.8	0.5	0.9
Active lever presses in extinction session 6	1.2	1.2	2.2	-1.5	-1.5	-1.0	-1.0	-0.9	-1.0	0.9	1.0
Bone: final force	0.1	0.2	0.2	0.4	0.4	-0.5	-0.3	-0.4	-0.3	0.5	0.4
Bone: final moment	0.1	0.1	0.2	0.4	0.5	-0.3	-0.2	-0.3	-0.2	0.4	0.3
Food consumed during 24 hour testing period	0.2	0.3	0.5	-0.6	-0.7	-0.3	-0.6	-0.5	-0.5	0.5	0.6
Glucose	3.1	4.9	7.0	2.6	2.6	2.1	2.1	2.0	2.0	-2.1	-1.9
Heart weight	2.1	3.4	3.7	-1.8	-1.8	-1.9	-1.8	-1.8	-1.9	1.9	1.8
Delay discount hyperbolic model param	0.6	0.8	1.5	-1.2	-1.2	-0.6	-0.8	-0.7	-0.7	0.8	0.6
Intermittent access intake day 1-15 change	0.3	1.6	2.2	0.9	0.9	1.3	1.3	1.2	1.5	-1.3	-1.5
Intermittent access intake escalation	0.3	1.7	2.4	0.9	0.9	1.4	1.3	1.3	1.5	-1.3	-1.5
Intermittent access intake escalation 2	1.2	2.1	2.8	1.1	1.1	1.5	1.5	1.4	1.7	-1.4	-1.7
Intermitt. access day 1 inactive lever presses	0.3	4.2	5.2	2.0	1.9	2.3	2.0	2.0	2.2	-1.9	-2.2
Intermitt. access day 15 inactive lever presses	0.9	4.6	5.7	2.0	2.0	2.4	2.2	2.3	2.0	-2.2	-2.1
Intermitt. access escalation Index	0.7	2.1	3.6	-1.0	-1.0	-1.4	-1.6	-1.5	-1.6	1.9	1.6
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.1	0.2	-0.1	0.2	0.2	0.1	-0.1	-0.0
Intermittent access day 15 total infusions	0.1	0.4	0.6	0.2	0.2	0.6	0.7	0.7	0.8	-0.6	-0.7
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.3	-0.5	-0.5	-0.1	-0.0	0.1	0.1	0.0	-0.0
Intermittent access total infusions	0.2	0.2	0.4	0.1	0.2	0.4	0.5	0.6	0.5	-0.4	-0.5
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.5	0.5	0.0	0.3	0.3	0.2	-0.3	-0.1
Intermittent access day 15 total locomotion	0.2	0.6	0.8	0.7	0.8	0.7	0.8	0.9	0.8	-0.7	-0.8
Intermittent access total locomotion	0.2	0.3	0.3	0.4	0.4	0.4	0.6	0.6	0.6	-0.6	-0.5
Intermittent access standard deviation	0.4	2.3	3.1	0.8	0.8	1.7	1.6	1.7	1.8	-1.6	-1.8
Left kidney weight	0.1	0.6	2.5	1.5	1.6	-0.3	0.1	-0.1	-0.2	0.1	0.2
Right kidney weight	0.1	0.6	0.9	0.9	1.0	-0.9	-0.5	-0.8	-0.7	0.7	0.7
Cocaine induced anxiety	0.1	0.3	0.5	0.5	0.4	0.7	0.6	0.6	0.6	-0.5	-0.6
Post-drug Anxiety	0.8	0.9	1.1	-0.8	-0.9	-0.8	-1.1	-0.9	-1.0	1.0	1.0
Baseline Anxiety	1.4	2.3	2.6	-1.4	-1.5	-1.4	-1.6	-1.6	-1.6	1.5	1.6
Tail length	1.7	9.4	12.7	-2.2	-2.1	-3.6	-3.1	-3.4	-3.3	3.2	3.3
Length with tail	2.1	9.4	12.8	-2.0	-1.9	-3.6	-3.2	-3.5	-3.3	3.3	3.3
Length without tail	0.7	3.7	5.7	-1.5	-1.4	-2.4	-1.9	-2.0	-2.0	1.9	2.1
Times rat made contact with spout	0.1	0.1	0.4	0.6	0.6	-0.0	-0.0	-0.1	-0.1	0.1	0.2
Lifetime Intake	0.1	0.2	0.3	0.1	0.2	0.4	0.4	0.6	0.4	-0.4	-0.4
Liver weight, left	8.1	13.9	15.7	-3.1	-3.1	-3.8	-4.0	-3.9	-3.9	3.9	3.9
Liver weight, right	6.2	10.8	11.9	-2.9	-2.8	-3.4	-3.4	-3.4	-3.4	3.4	3.4
Locomotor activity	0.1	0.1	0.2	-0.3	-0.3	-0.5	-0.2	-0.2	-0.3	0.1	0.3
Locomotor testing distance	0.0	0.0	0.2	-0.2	-0.2	-0.4	-0.1	-0.1	-0.1	0.0	0.2
Locomotor testing rearing	0.0	0.0	0.1	-0.4	-0.3	-0.2	0.2	0.1	0.1	-0.3	0.0
Locomotion in novel chamber	4.8	6.5	8.3	2.1	2.1	2.6	2.6	2.7	2.6	-2.9	-2.7
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	-0.1	-0.2	0.3	0.3	0.4	0.3	-0.4	-0.3
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	-0.2	-0.2	-0.3	-0.2	-0.2	-0.3	0.2	0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.2	0.4	0.3	0.3	-0.1	0.0	-0.0	-0.0	0.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.3	-0.4	0.1	-0.2	-0.1	-0.1	0.2	-0.1
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.3	-0.1	-0.2	0.2	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.2	-0.1	-0.2	0.4	-0.1	0.1	0.0	0.1	0.0
Rest time, locomotor task time 1	0.4	0.7	1.3	0.7	0.6	1.1	0.7	0.9	0.8	-0.8	-0.8
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	-0.2	-0.2	-0.1	-0.2	-0.1	0.1	0.2
Vertical activity count, locomotor time 1	0.1	0.4	0.7	-0.8	-0.8	-0.7	-0.5	-0.5	-0.5	0.5	0.5
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.5	0.7	0.7	0.6	0.4	0.5	0.5	-0.3	-0.6
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.2	0.2	0.1	0.0	0.1	0.1	-0.0	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.2	-0.1	-0.1	0.2	0.3
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.2	-0.3	0.2	-0.1	0.1	-0.1	0.0	-0.2
Distance moved, locomotor task time 2	0.4	0.6	0.8	0.6	0.7	0.6	0.9	0.8	0.8	-0.9	-0.7
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.5	0.5	0.2	0.4	0.3	0.3	-0.3	-0.2
Light reinforcement 1	0.0	0.1	0.3	-0.2	-0.0	-0.6	0.1	-0.1	-0.1	-0.1	-0.1
Light reinforcement 2	0.4	0.8	2.3	1.4	1.5	0.3	0.9	0.6	0.6	-0.7	-0.6
Bone: marrow area	0.0	0.0	0.2	-0.4	-0.4	-0.2	-0.1	-0.1	-0.0	0.1	-0.0
Bone: maximum diameter	0.2	0.4	0.7	0.3	0.3	0.8	0.6	0.6	0.7	-0.7	-0.8
Bone: maximum force	0.1	0.1	0.5	0.7	0.7	-0.1	0.0	-0.2	-0.0	0.1	0.1
Bone: maximum moment	0.1	0.1	0.6	0.7	0.8	0.1	0.2	0.0	0.2	-0.0	-0.1
Mean time between licks in bursts	0.2	0.9	1.4	-0.7	-0.7	-1.2	-1.0	-1.0	-1.0	1.1	1.0
Mean num. licks in bursts	0.2	0.5	1.2	-0.4	-0.5	-0.2	-0.9	-0.7	-0.7	0.7	1.1
Cd content in liver	0.1	0.1	0.2	-0.3	-0.3	0.4	0.2	0.3	0.3	-0.4	-0.3
Co content in liver	0.0	0.0	0.1	0.3	0.3	0.3	0.1	0.1	0.1	-0.2	-0.2
Cu content in liver	0.5	0.6	0.9	1.0	0.9	0.8	0.7	0.7	0.7	-0.6	-0.7
Fe content in liver	0.7	0.9	1.1	-0.7	-0.7	-1.1	-1.0	-1.0	-1.0	1.0	1.0
K content in liver	0.6	0.6	1.2	-0.3	-0.2	-1.1	-0.7	-0.9	-0.9	0.8	0.8
Mg content in liver	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	0.0	0.0	-0.1	-0.1
Mn content in liver	0.0	0.1	0.1	-0.4	-0.4	0.2	0.1	0.1	0.1	-0.2	-0.1
Na content in liver	0.7	0.8	2.0	1.4	1.4	0.6	0.8	0.6	0.6	-0.6	-0.6
Rb content in liver	0.9	1.1	2.8	-1.7	-1.7	-0.9	-0.8	-0.7	-0.7	0.6	0.7
Se content in liver	0.2	0.3	0.5	0.7	0.7	0.4	0.4	0.4	0.4	-0.4	-0.4
Sr content in liver	0.2	0.2	0.7	-0.8	-0.8	-0.1	-0.4	-0.2	-0.2	0.2	0.3
Zn content in liver	0.5	0.6	0.9	-0.7	-0.7	-0.5	-0.9	-0.8	-0.8	0.8	0.8
Bone: minimum diameter	0.1	0.2	0.6	0.8	0.8	0.2	0.2	0.1	0.2	-0.1	-0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.3	-0.3	0.5	0.4	0.5	0.4	-0.6	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.3	0.4	-0.4	-0.3	-0.3	-0.4	0.5	0.4
Total zone transitions, hab. session 1	0.1	0.2	0.6	-0.8	-0.6	-0.6	0.3	0.2	0.2	-0.3	-0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.4	-0.6	-0.5	-0.6	-0.0	-0.1	-0.1	0.1	0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.3	-0.6	-0.5	-0.5	0.1	-0.0	-0.0	-0.0	0.1
Time in familiar zone, hab. session 2	0.3	0.3	1.0	-1.0	-0.9	-0.6	-0.3	-0.3	-0.4	0.3	0.3
Time in novel zone, hab. session 2	0.9	1.0	2.7	1.6	1.6	0.9	0.7	0.6	0.6	-0.7	-0.6
Total zone transitions, hab. session 2	0.5	0.7	1.5	-1.1	-0.9	-1.2	-0.5	-0.7	-0.6	0.6	0.7
Total locomotion distance, hab. session 2	0.1	0.2	0.5	-0.4	-0.3	-0.7	-0.3	-0.4	-0.3	0.4	0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.3	-0.2	-0.6	-0.2	-0.3	-0.3	0.3	0.3
Novel to familiar place preference ratio	0.4	0.5	1.0	0.5	0.5	1.0	0.7	0.8	0.8	-0.6	-0.7
Novelty place preference	0.1	0.1	0.4	0.3	0.2	0.6	0.2	0.4	0.3	-0.2	-0.3
Time in novel zone, NPP test	0.0	0.0	0.1	-0.0	-0.1	0.3	0.0	0.1	0.1	0.0	-0.1
Total zone transitions, NPP test	0.2	0.2	0.7	-0.8	-0.6	-0.9	0.1	-0.1	-0.0	0.1	0.1
Total locomotion distance, NPP test	0.1	0.2	0.4	0.0	0.1	-0.1	0.7	0.5	0.5	-0.5	-0.5
Locomotion velocity, NPP test	0.5	0.8	1.2	0.5	0.6	0.5	1.1	1.0	1.0	-1.0	-0.9
Intraocular pressure	1.2	1.9	2.6	0.8	0.9	1.3	1.6	1.4	1.6	-1.6	-1.6
Delta distance traveled before/after self-admin	2.4	2.6	3.3	-1.8	-1.8	-1.3	-1.7	-1.5	-1.6	1.5	1.6
Delta ambulatory time before/after self-admin	1.3	2.2	3.0	-1.7	-1.7	-1.1	-1.6	-1.4	-1.5	1.4	1.5
Parametrial fat weight	8.8	20.8	24.8	-5.0	-4.9	-4.7	-4.4	-4.3	-4.4	4.2	4.4
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.1	0.1	0.5	0.5	0.6	0.6	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.7	0.9	1.3	-0.7	-0.8	-0.7	-1.1	-1.0	-1.0	1.0	1.0
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.7	0.7	0.5	0.4	0.3	0.3	-0.5	-0.4
Pavlov. Cond. index score	0.8	1.0	1.4	-0.7	-0.8	-1.0	-1.2	-1.2	-1.1	1.0	1.1
Pavlov. Cond. latency score	1.0	1.3	1.7	-0.7	-0.8	-1.1	-1.3	-1.3	-1.3	1.2	1.2
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.1	-0.1	-0.4	-0.5	-0.6	-0.5	0.4	0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.4	0.5	0.3	0.6	0.5	0.5	-0.4	-0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	0.2	0.3	0.1	0.9	0.7	0.8	-0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.0	-0.6	-0.7	-0.8	-1.0	-1.0	-1.0	0.8	0.9
Pavlov. Cond. response bias	0.5	0.6	0.8	-0.7	-0.7	-0.7	-0.9	-0.9	-0.8	0.8	0.8
Pavlov. Cond. lever latency	1.3	1.9	2.6	-1.5	-1.6	-1.0	-1.5	-1.3	-1.4	1.4	1.1
Pavlov. Cond. magazine entry latency	0.2	0.3	1.1	0.9	1.0	-0.1	0.5	0.2	0.3	-0.5	-0.4
Pavlov. Cond. change in total contacts	0.4	1.0	1.7	1.2	1.3	0.6	1.0	0.8	0.9	-0.9	-0.9
Pavlov. Cond. index score	1.4	2.2	3.4	1.7	1.8	1.0	1.6	1.4	1.4	-1.5	-1.3
Pavlov. Cond. latency score	1.7	2.8	4.0	1.9	2.0	1.2	1.8	1.5	1.6	-1.7	-1.5
Pavlov. Cond. lever contacts	0.5	0.7	1.3	1.0	1.1	0.4	0.9	0.7	0.8	-0.9	-0.6
Pavlov. Cond. magazine entry number	0.5	0.6	1.5	-1.1	-1.2	-0.2	-0.8	-0.5	-0.6	0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.5	1.1	2.4	-1.5	-1.5	-0.8	-0.9	-0.8	-0.8	1.0	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.4	2.1	3.1	1.7	1.8	1.0	1.6	1.3	1.4	-1.5	-1.3
Pavlov. Cond. response bias	0.6	0.9	1.8	1.3	1.3	0.5	1.0	0.8	0.8	-0.9	-0.7
Time in closed arm before self-admin	1.9	3.3	3.5	-1.8	-1.8	-1.8	-1.9	-1.8	-1.8	1.9	1.9
Time in closed arm after self-admin	0.2	0.2	0.4	0.6	0.6	0.4	0.4	0.4	0.3	-0.3	-0.4
Time in open arm before self-admin	3.3	4.1	5.3	2.3	2.3	2.0	1.9	1.8	1.8	-1.9	-2.0
Time in open arm after self-admin	0.8	0.8	1.0	0.9	0.9	1.0	0.9	0.9	0.9	-1.0	-0.8
Bone: periosteal estimation	0.1	0.2	0.3	0.6	0.6	0.3	0.4	0.3	0.4	-0.3	-0.4
Bone: periosteal perimeter	0.2	0.3	0.4	0.5	0.4	0.6	0.5	0.5	0.6	-0.5	-0.6
Bone: post-yield work	0.6	1.1	1.3	-1.0	-1.0	-1.1	-1.0	-1.2	-1.0	1.2	0.8
Progressive ratio test 1 active lever presses	0.2	0.3	0.4	0.5	0.5	0.5	0.6	0.7	0.6	-0.5	-0.5
Progressive ratio test 1 breakpoint	0.2	0.3	0.5	0.4	0.5	0.5	0.7	0.7	0.6	-0.5	-0.5
Progressive ratio test 1 inactive lever presses	1.2	3.0	3.4	1.8	1.7	1.8	1.7	1.7	1.8	-1.7	-1.7
Progressive ratio test 2 active lever presses	0.2	0.3	0.5	-0.0	-0.0	0.6	0.6	0.7	0.6	-0.5	-0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.1	-0.1	0.5	0.5	0.7	0.6	-0.4	-0.6
Progressive ratio test 2 inactive lever presses	0.4	1.3	1.6	0.8	0.8	1.2	1.2	1.3	1.2	-1.2	-1.2
Incentive Sensitization - Responses	0.0	0.1	0.2	-0.4	-0.4	0.3	0.2	0.3	0.4	-0.2	-0.4
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	-0.4	-0.4	0.3	0.2	0.3	0.4	-0.1	-0.4
Sum of active levers in priming session hrs 5-6	3.7	3.5	3.8	-1.9	-1.9	-1.7	-1.9	-1.9	-1.9	1.8	1.9
Progressive ratio	0.2	0.6	1.0	0.5	0.5	0.6	0.9	0.8	0.8	-1.0	-0.9
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.3	0.3	-0.2	-0.3
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.4	0.4	0.0	-0.1	-0.2	-0.1	0.3	0.1
Retroperitoneal fat weight	0.2	1.0	2.0	-1.0	-0.9	-1.4	-0.8	-1.0	-0.8	0.9	0.9
Reaction time number correct	0.0	0.2	0.3	-0.4	-0.4	-0.5	-0.3	-0.4	-0.5	0.4	0.3
Reaction time mean minus median	0.1	0.5	0.7	0.4	0.4	0.8	0.7	0.7	0.7	-0.7	-0.8
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.4	-0.4	0.3	0.2	0.3	0.2	-0.3	-0.4
Reaction time num false alarms	0.6	1.0	1.6	0.5	0.6	0.8	1.3	1.2	1.2	-1.2	-1.1
Reaction time num false alarms AUC	0.4	1.0	1.6	0.5	0.6	0.8	1.2	1.2	1.2	-1.1	-1.1
Reaction time trials correct on left	0.0	0.2	0.3	-0.4	-0.4	-0.5	-0.3	-0.4	-0.5	0.4	0.3
Reaction time trials on left	0.0	0.1	0.2	-0.4	-0.4	-0.5	-0.3	-0.3	-0.4	0.3	0.3
Reaction time mean	0.0	0.1	0.3	0.3	0.3	0.5	0.2	0.3	0.2	-0.3	-0.3
Reaction time mean AUC	0.2	0.5	0.9	0.7	0.6	0.9	0.6	0.7	0.6	-0.7	-0.7
Median of all reaction times	0.0	0.1	0.1	0.3	0.3	0.4	0.1	0.2	0.1	-0.2	-0.1
Reaction time omissions	0.0	0.0	0.1	-0.3	-0.3	-0.1	-0.2	-0.1	-0.2	0.0	0.2
Reaction time false alarm rate	0.6	0.9	1.3	0.5	0.5	0.9	1.1	1.1	1.1	-1.0	-1.0
Reaction time premature initiation rate	0.1	0.2	0.5	-0.7	-0.7	-0.2	-0.4	-0.3	-0.4	0.4	0.4
Reaction time premature initiations	0.1	0.3	0.6	-0.8	-0.8	-0.4	-0.4	-0.4	-0.5	0.4	0.4
Std. dev. reaction times	0.1	0.4	0.7	0.3	0.3	0.8	0.6	0.7	0.6	-0.6	-0.7
Reaction time trials completed	0.0	0.1	0.2	-0.4	-0.4	-0.5	-0.3	-0.3	-0.4	0.3	0.3
Reaction time trials AUC	0.0	0.1	0.2	-0.4	-0.3	-0.4	-0.2	-0.3	-0.4	0.3	0.2
Run reversals in cocaine runway, females	0.7	0.8	1.1	0.6	0.6	0.8	1.0	1.0	0.9	-1.0	-1.1
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.1	-0.2	0.4	0.4	0.4	0.5	-0.3	-0.5
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.2	0.3	0.0	0.1	0.1	-0.0	-0.1	-0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.2	-0.2	-0.6	-0.5	-0.5	-0.6	0.5	0.5
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	0.4	0.4	0.4	0.4	0.4	0.4	-0.4	-0.4
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.4	-0.4	-0.3	-0.1	-0.2	-0.1	0.1	0.1
Total sessions with >9 infusions	0.2	0.2	0.4	0.2	0.2	0.6	0.5	0.7	0.5	-0.6	-0.4
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.3	-0.3	-0.1	-0.3	-0.3	-0.1	0.3	0.1
Short access day 10 total inactive lever presses	0.2	1.0	1.3	1.1	1.1	1.1	0.9	0.9	1.0	-1.1	-1.0
Short access day 1 total infusions	0.7	1.4	1.8	1.0	1.0	1.4	1.2	1.3	1.2	-1.3	-1.1
Short access day 10 total infusions	0.4	0.7	1.0	0.6	0.6	0.8	0.9	1.0	0.9	-0.8	-0.8
Short access total infusions	0.8	1.1	1.4	0.9	0.9	1.1	1.1	1.2	1.0	-1.1	-1.0
Short access day 1 locomotion	1.3	2.2	2.6	1.5	1.6	1.5	1.6	1.5	1.4	-1.6	-1.3
Short access day 10 total locomotion	0.4	1.6	1.8	1.3	1.3	1.3	1.3	1.2	1.2	-1.3	-1.2
Short access total locomotion	2.2	3.3	3.5	1.8	1.8	1.9	1.9	1.9	1.8	-1.9	-1.7
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.6	-0.6	-0.0	-0.0	0.1	0.0	0.1	0.0
Compulsive drug intake	1.1	1.6	2.0	-1.1	-1.1	-1.3	-1.4	-1.3	-1.4	1.2	1.4
One hour access (shock baseline)	0.1	0.4	0.5	0.4	0.4	0.6	0.7	0.7	0.7	-0.5	-0.7
Social response proportion	3.7	4.6	5.4	-1.9	-1.9	-2.1	-2.3	-2.2	-2.3	2.0	2.3
Social responses	2.4	3.1	3.3	-1.8	-1.8	-1.8	-1.8	-1.7	-1.8	1.6	1.8
Social time	2.3	3.7	4.3	-2.1	-2.0	-1.9	-1.9	-1.8	-1.9	1.9	1.9
Soleus weight	4.7	13.8	15.0	-3.8	-3.8	-3.9	-3.7	-3.7	-3.5	3.8	3.6
Bone: stiffness	1.5	2.7	3.4	-1.4	-1.4	-1.8	-1.7	-1.8	-1.6	1.8	1.5
Tibialis anterior weight	4.4	15.0	27.2	-5.2	-5.2	-3.6	-3.4	-3.2	-3.2	3.2	3.2
Time to tail flick, vehicle, before self-admin	3.9	4.8	7.5	-2.7	-2.7	-2.0	-2.1	-2.0	-2.0	2.0	1.9
Time to tail flick, vehicle, after self-admin	0.1	0.3	0.4	-0.6	-0.6	-0.5	-0.4	-0.4	-0.4	0.4	0.4
Time to tail flick, test, before self-admin	1.0	1.1	1.2	-1.1	-1.1	-1.1	-1.1	-1.1	-1.0	1.1	1.0
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.1	0.1	-0.1	-0.2	-0.2	-0.2	0.2	0.3
Delta time to tail flick, vehicle, before/after SA	1.4	1.5	1.7	1.3	1.3	1.3	1.2	1.2	1.2	-1.2	-1.2
Delta time to tail flick, test, before/after SA	0.7	0.8	1.1	0.8	0.8	1.1	0.9	1.0	0.9	-1.0	-0.8
Tibia length	0.5	1.5	2.2	-0.4	-0.4	-1.3	-1.4	-1.5	-1.4	1.3	1.4
Ambulatory time before self-admin	1.1	3.4	5.9	2.4	2.4	1.4	1.8	1.6	1.7	-1.6	-1.7
Ambulatory time after self-admin	0.1	0.1	0.2	0.2	0.2	-0.3	-0.3	-0.4	-0.4	0.4	0.4
Bone: tissue strength	0.8	0.8	1.9	1.3	1.4	0.6	0.8	0.7	0.8	-0.7	-0.7
Total heroin consumption	4.9	5.8	7.0	-2.6	-2.6	-2.4	-2.4	-2.3	-2.3	2.2	2.4
Bone: trabecular number	2.8	5.2	8.4	-2.9	-2.9	-2.3	-2.1	-1.9	-2.0	1.8	2.1
Bone: trabecular spacing	0.6	0.9	1.1	1.1	1.0	1.0	0.9	0.8	0.8	-0.8	-1.0
Bone: trabecular thickness	0.3	0.5	0.7	-0.8	-0.8	-0.8	-0.6	-0.5	-0.6	0.6	0.7
Bone: trabecular tissue density	1.3	2.3	3.5	1.9	1.9	1.5	1.4	1.3	1.4	-1.4	-1.4
Water consumed over 24 hours	0.1	0.2	0.4	0.1	0.1	-0.4	-0.5	-0.5	-0.6	0.5	0.7
Number of responses in last shaping day	2.0	2.6	3.2	1.6	1.6	1.6	1.7	1.6	1.6	-1.8	-1.5