Hub : Genes

Wdr81

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Wdr81	0.04	0.03	2.1e-04	0	0.03	0.03	0.02	1.2e-01	1.5e-03	2.0e-03	1.2e-02
2	BLA	gene expression	Wdr81	0.06	0.04	4.7e-03	-0	0.03	0.02	0.01	3.7e-01	8.2e-03	2.3e-02	9.1e-02
3	PL	gene expression	Wdr81	0.22	0.17	3.8e-12	0.1	0.11	0.1	0.1	7.7e-11	7.6e-12	9.8e-11	4.2e-11
4	Liver	mRNA stability	Wdr81	0.03	0.02	6.0e-04	0.03	0.02	0.03	0.03	3.5e-04	2.0e-03	3.2e-04	6.6e-04
5	IL	gene expression	Wdr81	0.31	0.15	1.9e-05	0.21	0.18	0.14	0.15	1.0e-05	3.7e-05	2.5e-04	2.0e-04
6	Brain	intron excision ratio	chr10_60286949_60288749	0.03	0.02	9.5e-03	0.02	0.02	0.01	0.02	2.3e-03	6.4e-03	1.4e-02	5.4e-03
7	NAcc	gene expression	Wdr81	0.04	0.03	3.7e-05	0.05	0.03	0.04	0.04	2.1e-06	1.6e-04	4.0e-05	1.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	2.9	4.9	7.7	-2.8	-2.7	-2.1	-2.0	1.9	1.9	1.9
Area under the delay curve	1.0	1.1	2.1	1.5	1.3	0.7	1.0	-0.8	-0.8	-0.8
BMI with tail	0.5	1.7	3.0	-1.7	-1.7	-1.3	-1.3	1.0	1.0	1.0
BMI without tail	0.5	1.0	1.2	-0.9	-0.9	-0.9	-1.0	1.0	1.1	1.1
Body weight	2.4	10.0	12.7	-2.7	-3.0	-3.6	-3.2	3.1	3.2	3.2
Weight adjusted by age	0.4	0.5	0.9	-0.9	-0.9	-0.7	-0.7	0.5	0.6	0.6
Bone surface	1.8	3.2	5.5	-2.3	-2.3	-1.9	-1.6	1.5	1.4	1.4
Bone volume	2.0	3.3	5.8	-2.4	-2.3	-1.8	-1.6	1.5	1.4	1.4
Breakpoint value in progressive ratio session	2.1	2.3	2.7	-1.2	-1.4	-1.7	-1.5	1.6	1.6	1.6
Number of licking bursts	0.3	0.4	0.7	0.8	0.7	0.4	0.6	-0.6	-0.6	-0.6
Context. condit. distance diff. score	1.3	1.5	2.3	-1.5	-1.4	-1.0	-1.2	1.2	1.1	1.1
Locomotion velocity, session 1	4.2	4.6	5.1	-2.2	-2.3	-2.1	-2.2	2.1	2.1	2.1
Locomotion distance, session 1	0.3	0.4	0.7	-0.8	-0.8	-0.8	-0.5	0.4	0.4	0.4
Locomotion velocity, session 2	0.7	0.8	1.1	-1.1	-1.0	-0.9	-0.9	0.8	0.8	0.8
Locomotion distance, session 2	0.9	1.2	2.1	-1.5	-1.4	-1.2	-1.0	0.9	0.8	0.8
Locomotion velocity, session 3	2.3	2.7	5.6	2.4	2.2	1.3	1.5	-1.2	-1.3	-1.3
Locomotion distance, session 3	0.1	0.1	0.2	0.2	0.2	0.3	0.4	-0.5	-0.4	-0.4
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	-0.1	-0.2	-0.5	-0.4	0.6	0.5	0.5
Stereotopy head waving duration, day 3	0.3	0.4	0.6	0.8	0.7	0.4	0.6	-0.6	-0.6	-0.6
Locomotion velocity, session 7	0.3	0.3	1.0	-1.0	-0.8	-0.3	-0.4	0.3	0.3	0.3
Locomotion distance, session 7	0.7	0.9	2.1	-1.4	-1.3	-0.6	-0.8	0.6	0.6	0.6
Stereotopy head waving bouts, day 7	0.8	0.9	1.3	-0.9	-1.0	-1.2	-0.9	0.9	0.8	0.8
Stereotopy head waving duration, day 7	1.0	1.2	2.0	-1.1	-1.2	-1.4	-1.0	1.0	0.9	0.9
Locomotion velocity, session 8	0.2	0.2	0.5	-0.7	-0.6	-0.4	-0.4	0.2	0.3	0.3
Locomotion distance, session 8	2.4	3.6	4.4	-2.1	-2.1	-2.0	-1.8	1.8	1.7	1.7
Degree of sensitization distance	1.4	1.4	1.8	-1.4	-1.3	-1.0	-1.2	1.2	1.2	1.2
Degree of sensitization stereotypy	1.5	1.7	2.1	-1.3	-1.4	-1.5	-1.3	1.3	1.2	1.2
Conditioned locomotion	0.9	1.1	1.7	0.8	0.9	1.3	1.1	-1.0	-1.0	-1.0
Cocaine response after cond. corrected	0.3	0.4	0.5	-0.6	-0.5	-0.4	-0.7	0.6	0.7	0.7
Cocaine response after cond. not corrected	0.9	1.0	1.3	-0.9	-0.9	-0.9	-1.1	1.0	1.1	1.1
Cocaine response before conditioning	1.0	1.2	1.9	-1.1	-1.2	-1.4	-1.0	1.0	1.0	1.0
Saline control response	0.2	0.2	0.6	-0.6	-0.6	-0.7	-0.4	0.2	0.3	0.3
Bone: connectivity density	3.5	5.5	9.5	-3.1	-3.0	-2.2	-2.1	2.0	1.9	1.9
Bone: cortical apparent density	0.7	1.0	1.4	0.7	0.8	1.2	1.0	-1.1	-1.0	-1.0
Bone: cortical area	1.3	2.0	2.9	1.7	1.7	1.4	1.4	-1.1	-1.2	-1.2
Bone: cortical porosity	0.2	0.2	0.2	-0.4	-0.5	-0.5	-0.5	0.4	0.4	0.4
Bone: cortical porosity	0.0	0.0	0.1	-0.1	-0.1	-0.3	-0.2	0.2	0.2	0.2
Bone: cortical thickness	2.5	4.2	8.0	2.8	2.7	1.9	1.9	-1.5	-1.5	-1.5
Bone: cortical thickness	0.1	0.2	0.6	0.8	0.7	0.1	0.2	0.1	0.0	0.0
Bone: cortical tissue density	0.5	0.7	1.0	0.5	0.7	1.0	0.8	-0.9	-0.9	-0.9
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	0.2	0.1	-0.0	-0.1	0.1	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.9	1.0	0.8	0.0	0.0	0.2	0.2	0.2
Condit. Reinf. active responses	0.1	0.1	0.4	-0.6	-0.5	-0.2	-0.3	0.3	0.2	0.2
Condit. Reinf. inactive responses	0.3	0.4	1.7	-1.3	-1.0	0.0	-0.0	-0.2	-0.2	-0.2
Incentive salience index mean	0.1	0.2	0.3	-0.2	-0.2	-0.3	-0.4	0.5	0.5	0.5
Condit. Reinf. lever presses	1.3	1.7	2.1	-1.2	-1.2	-1.2	-1.4	1.4	1.4	1.4
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.7	-0.6	-0.5	-0.5	0.4	0.4	0.4
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	-0.0	-0.1	-0.1	-0.2	0.3	0.3	0.3
Condit. Reinf. active responses	0.2	0.2	0.6	-0.8	-0.7	-0.6	-0.3	0.1	0.2	0.2
Condit. Reinf. inactive responses	0.2	0.2	0.5	-0.7	-0.7	-0.3	0.1	-0.4	-0.4	-0.4
Condit. Reinf. lever presses	0.8	1.1	1.7	0.9	0.9	0.7	1.1	-1.3	-1.2	-1.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.4	-0.6	-0.6	-0.5	-0.2	-0.0	0.0	0.0
Conditioned reinforcement - actives	0.6	0.6	1.7	-1.3	-1.1	-0.4	-0.6	0.4	0.3	0.3
Conditioned reinforcement - inactives	0.1	0.1	0.4	-0.6	-0.5	0.0	-0.1	0.0	0.1	0.1
Conditioned locomotion	0.3	0.4	0.6	0.6	0.5	0.4	0.5	-0.8	-0.8	-0.8
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3	0.1	0.4	0.4
Patch foraging indifference point AUC	0.9	1.0	1.5	0.7	0.8	1.2	1.0	-1.2	-1.0	-1.0
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.0	-0.1	-0.4	-0.2	0.1	0.1	0.1
Delay disc. indifference point, 16s delay	0.7	0.7	1.2	1.1	1.0	0.6	0.8	-0.8	-0.8	-0.8
Delay disc. indifference point, 2s delay	0.8	0.9	1.8	1.3	1.2	0.6	0.9	-0.8	-0.8	-0.8
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.5	0.5	0.4	0.4	-0.3	-0.3	-0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.9	0.9	0.8	0.3	0.4	-0.3	-0.3	-0.3
Delay disc. indifference point, 8s delay	0.4	0.4	0.9	1.0	0.8	0.4	0.6	-0.4	-0.5	-0.5
Indifference point function ln k	0.6	0.8	1.2	-1.1	-1.1	-0.8	-0.9	0.9	0.8	0.8
Indifference point function log k	0.6	0.8	1.2	-1.1	-1.1	-0.8	-0.9	0.9	0.8	0.8
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	-0.4	-0.4	-0.2	-0.2	-0.1	0.3	0.3
Patch foraging total patch changes 12 sec	0.3	0.4	0.7	0.8	0.8	0.5	0.6	-0.6	-0.4	-0.4
Patch foraging total patch changes 18 sec	0.3	0.3	1.0	1.0	0.8	0.2	0.5	-0.5	-0.2	-0.2
Patch foraging total patch changes 24 sec	0.8	0.9	1.4	1.2	1.1	0.9	1.0	-1.0	-0.7	-0.7
Patch foraging total patch changes 6 sec	0.5	0.7	1.3	0.7	0.7	0.8	0.9	-1.2	-0.7	-0.7
Patch foraging time to switch 0 sec	0.1	0.2	0.6	0.8	0.5	-0.4	-0.1	0.4	0.1	0.1
Patch foraging water rate 0 sec	0.1	0.2	0.4	-0.1	-0.0	0.4	0.4	-0.6	-0.4	-0.4
Patch foraging water rate 12 sec	0.0	0.1	0.1	-0.1	-0.2	-0.2	-0.2	0.1	0.4	0.4
Patch foraging water rate 18 sec	1.4	1.9	3.2	-1.8	-1.8	-1.4	-1.2	1.1	1.1	1.1
Patch foraging water rate 24 sec	0.0	0.0	0.1	-0.2	-0.1	0.0	0.2	-0.3	-0.2	-0.2
Patch foraging water rate 6 sec	0.4	0.6	0.8	0.6	0.7	0.9	0.8	-0.9	-0.8	-0.8
Seeking ratio, delayed vs. immediate footshock	2.2	2.6	3.0	1.7	1.7	1.3	1.7	-1.6	-1.6	-1.6
Distance traveled before self-admin	1.8	1.9	2.8	1.7	1.6	1.2	1.4	-1.2	-1.2	-1.2
Distance traveled after self-admin	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.1	0.1
Extensor digitorum longus weight	1.9	7.5	17.2	-4.1	-3.8	-2.3	-2.3	1.9	1.8	1.8
Bone: elastic displacement	0.9	1.0	1.2	0.9	0.9	1.0	1.0	-1.1	-1.0	-1.0
Bone: elastic work	2.3	3.0	5.5	2.3	2.2	1.5	1.7	-1.4	-1.3	-1.3
Bone: endosteal estimation	0.0	0.0	0.0	-0.2	-0.1	-0.0	0.1	-0.1	-0.1	-0.1
Bone: endosteal perimeter	0.1	0.1	0.5	-0.7	-0.5	0.1	0.1	-0.2	-0.3	-0.3
Epididymis fat weight	3.9	9.2	10.6	-3.1	-3.3	-3.3	-3.0	2.9	2.8	2.8
Delta time in closed arm before/after self-admin	0.7	0.7	0.8	0.7	0.7	0.8	0.8	-0.9	-0.9	-0.9
Delta time in open arm before/after self-admin	1.6	1.5	1.9	-1.1	-1.2	-1.4	-1.2	1.2	1.2	1.2
Diff in mean of infusions in LGA sessions	1.2	1.4	1.7	-1.0	-1.0	-1.0	-1.3	1.3	1.3	1.3
Delay discount exponential model param	0.8	0.8	1.8	-1.4	-1.2	-0.6	-0.8	0.7	0.7	0.7
Extinction: sum of active levers before priming	1.5	1.5	2.6	-1.6	-1.5	-1.0	-1.3	1.0	1.1	1.1
Active lever presses in extinction session 6	1.0	1.0	1.6	-1.3	-1.2	-0.9	-1.0	0.9	0.9	0.9
Bone: final force	0.1	0.2	0.3	0.6	0.3	-0.4	-0.2	0.5	0.4	0.4
Bone: final moment	0.1	0.1	0.3	0.6	0.4	-0.3	-0.0	0.3	0.3	0.3
Food consumed during 24 hour testing period	0.3	0.3	0.5	-0.7	-0.7	-0.4	-0.5	0.5	0.5	0.5
Glucose	2.7	4.1	6.3	2.5	2.4	1.8	2.0	-1.8	-1.8	-1.8
Heart weight	0.3	0.4	0.8	-0.3	-0.5	-0.9	-0.6	0.6	0.7	0.7
Delay discount hyperbolic model param	0.9	0.9	1.9	-1.4	-1.2	-0.7	-0.9	0.7	0.7	0.7
Intermittent access intake day 1-15 change	1.2	1.2	1.7	0.5	0.7	1.3	1.3	-1.2	-1.2	-1.2
Intermittent access intake escalation	2.1	2.1	2.6	1.1	1.3	1.6	1.6	-1.5	-1.5	-1.5
Intermittent access intake escalation 2	2.8	2.8	3.4	1.5	1.6	1.8	1.9	-1.6	-1.6	-1.6
Intermitt. access day 1 inactive lever presses	2.6	2.8	3.7	1.9	1.9	1.7	1.7	-1.5	-1.5	-1.5
Intermitt. access day 15 inactive lever presses	1.3	1.4	1.7	1.1	1.1	1.2	1.1	-1.3	-1.3	-1.3
Intermitt. access escalation Index	5.4	4.8	5.8	-1.5	-1.7	-2.3	-2.4	2.4	2.4	2.4
Intermittent access day 1 total infusions	0.3	0.3	0.6	-0.8	-0.8	-0.7	-0.6	0.3	0.4	0.4
Intermittent access day 15 total infusions	0.3	0.3	0.5	-0.2	-0.0	0.5	0.5	-0.7	-0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.4	0.4	1.1	-1.0	-0.9	-0.5	-0.4	0.3	0.3	0.3
Intermittent access total infusions	0.1	0.1	0.1	-0.3	-0.2	0.1	0.2	-0.4	-0.3	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.5	0.4	0.0	0.1	-0.2	-0.2	-0.2
Intermittent access day 15 total locomotion	0.7	0.8	1.0	0.8	0.8	0.7	0.9	-1.0	-1.0	-1.0
Intermittent access total locomotion	0.1	0.1	0.1	0.3	0.3	0.2	0.3	-0.3	-0.3	-0.3
Intermittent access standard deviation	3.5	3.7	4.8	1.1	1.4	2.2	2.1	-2.1	-2.1	-2.1
Left kidney weight	0.5	1.3	5.2	2.3	1.8	0.0	0.6	-0.2	-0.2	-0.2
Right kidney weight	0.3	0.8	3.6	1.9	1.4	-0.3	0.3	0.3	0.1	0.1
Cocaine induced anxiety	0.6	0.7	1.1	0.4	0.5	1.1	0.9	-1.0	-1.0	-1.0
Post-drug Anxiety	0.0	0.0	0.1	-0.2	-0.1	0.2	0.1	-0.2	-0.2	-0.2
Baseline Anxiety	0.2	0.2	0.3	-0.2	-0.3	-0.5	-0.4	0.5	0.5	0.5
Tail length	2.8	8.4	11.7	-1.4	-1.9	-3.3	-2.9	3.3	3.4	3.4
Length with tail	1.8	6.8	9.1	-1.5	-1.9	-3.0	-2.6	2.8	2.9	2.9
Length without tail	1.6	3.5	5.1	-1.6	-1.8	-2.3	-1.9	1.8	1.8	1.8
Times rat made contact with spout	0.1	0.1	0.6	0.8	0.6	-0.0	0.0	0.1	0.1	0.1
Lifetime Intake	0.1	0.2	0.3	-0.2	-0.1	0.3	0.3	-0.5	-0.5	-0.5
Liver weight, left	1.2	1.9	2.8	-0.7	-0.9	-1.4	-1.4	1.7	1.7	1.7
Liver weight, right	1.1	1.9	2.5	-1.0	-1.1	-1.3	-1.4	1.6	1.5	1.5
Locomotor activity	0.1	0.1	0.3	-0.1	-0.2	-0.5	-0.3	0.1	0.3	0.3
Locomotor testing distance	0.0	0.0	0.1	-0.0	-0.1	-0.4	-0.2	-0.0	0.2	0.2
Locomotor testing rearing	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.0	-0.2	-0.3	-0.3
Locomotion in novel chamber	5.3	6.5	7.7	2.1	2.3	2.7	2.7	-2.8	-2.7	-2.7
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.1	-0.0	0.3	0.2	-0.4	-0.3	-0.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	-0.3	-0.5	-0.3	0.4	0.4	0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.4	0.3	0.0	0.0	0.0	0.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.3	-0.2	0.3	0.1	-0.0	-0.1	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.3	0.1	-0.2	0.1	0.1	0.1
Total resting periods, locomotor time 1	0.0	0.1	0.2	-0.4	-0.2	0.3	-0.0	-0.0	-0.0	-0.0
Rest time, locomotor task time 1	0.4	0.4	0.8	0.2	0.3	0.9	0.7	-0.7	-0.7	-0.7
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.2	-0.1	-0.0	-0.1	-0.0	0.0	0.0
Vertical activity count, locomotor time 1	0.3	0.3	0.5	-0.7	-0.7	-0.6	-0.5	0.3	0.4	0.4
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.8	0.9	0.9	0.8	0.7	-0.6	-0.6	-0.6
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.3	0.3	0.2	0.1	-0.1	-0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1	0.1	0.1	0.1
Rest time, locomotor task time 2	0.0	0.0	0.2	-0.4	-0.3	0.1	-0.0	0.1	0.1	0.1
Distance moved, locomotor task time 2	0.6	0.7	1.0	0.7	0.7	0.8	0.8	-1.0	-0.9	-0.9
Vertical activity count, locomotor time 2	0.3	0.3	0.6	0.8	0.7	0.4	0.5	-0.6	-0.5	-0.5
Light reinforcement 1	0.0	0.0	0.2	0.1	-0.1	-0.5	-0.0	-0.0	0.0	0.0
Light reinforcement 2	0.9	1.2	3.1	1.8	1.5	0.5	0.9	-0.6	-0.8	-0.8
Bone: marrow area	0.0	0.0	0.0	-0.2	-0.1	-0.0	0.1	-0.1	-0.1	-0.1
Bone: maximum diameter	0.3	0.6	1.0	0.3	0.4	1.0	0.8	-0.8	-0.8	-0.8
Bone: maximum force	0.1	0.2	0.7	0.9	0.7	-0.1	0.2	0.1	0.1	0.1
Bone: maximum moment	0.1	0.2	0.8	0.9	0.7	0.1	0.3	-0.0	-0.1	-0.1
Mean time between licks in bursts	0.5	0.7	1.1	-0.4	-0.5	-1.1	-0.9	0.9	0.9	0.9
Mean num. licks in bursts	0.3	0.3	0.5	-0.3	-0.3	-0.4	-0.6	0.7	0.7	0.7
Cd content in liver	0.4	0.5	1.0	-1.0	-0.9	-0.6	-0.6	0.4	0.5	0.5
Co content in liver	0.1	0.1	0.2	0.5	0.4	0.2	0.3	-0.4	-0.2	-0.2
Cu content in liver	0.2	0.2	0.6	0.8	0.7	0.3	0.2	-0.3	-0.1	-0.1
Fe content in liver	0.6	0.7	1.0	-0.4	-0.5	-0.9	-0.9	0.8	1.0	1.0
K content in liver	0.7	0.7	1.3	0.0	-0.2	-1.0	-0.8	1.2	1.0	1.0
Mg content in liver	0.1	0.1	0.1	0.2	0.2	0.2	0.3	-0.2	-0.3	-0.3
Mn content in liver	0.1	0.1	0.3	-0.5	-0.5	-0.3	-0.3	0.4	0.2	0.2
Na content in liver	1.1	1.1	2.9	1.7	1.5	0.7	0.9	-0.6	-0.7	-0.7
Rb content in liver	0.2	0.3	0.9	-1.0	-0.8	-0.2	-0.3	0.2	0.1	0.1
Se content in liver	0.4	0.5	1.0	1.0	0.9	0.6	0.6	-0.5	-0.5	-0.5
Sr content in liver	0.5	0.4	0.8	-0.9	-0.8	-0.5	-0.6	0.5	0.5	0.5
Zn content in liver	0.1	0.1	0.3	-0.5	-0.4	0.2	0.0	-0.1	-0.1	-0.1
Bone: minimum diameter	0.2	0.3	1.1	1.0	0.9	0.3	0.4	-0.2	-0.3	-0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.5	-0.3	0.5	0.3	-0.5	-0.5	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.6	0.4	-0.4	-0.2	0.4	0.4	0.4
Total zone transitions, hab. session 1	0.2	0.3	0.7	-0.8	-0.8	-0.6	-0.1	-0.1	-0.1	-0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.5	-0.6	-0.6	-0.7	-0.3	0.2	0.2	0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.4	-0.6	-0.6	-0.5	-0.2	0.1	0.1	0.1
Time in familiar zone, hab. session 2	0.4	0.4	1.2	-1.1	-1.0	-0.6	-0.5	0.3	0.3	0.3
Time in novel zone, hab. session 2	1.2	1.2	3.3	1.8	1.6	0.9	0.8	-0.6	-0.6	-0.6
Total zone transitions, hab. session 2	0.7	0.8	1.6	-1.0	-1.1	-1.3	-0.8	0.7	0.7	0.7
Total locomotion distance, hab. session 2	0.2	0.2	0.5	-0.3	-0.4	-0.7	-0.4	0.5	0.4	0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.3	-0.3	-0.5	-0.3	0.4	0.3	0.3
Novel to familiar place preference ratio	0.5	0.5	0.8	0.4	0.6	0.9	0.8	-0.8	-0.8	-0.8
Novelty place preference	0.1	0.1	0.3	0.2	0.3	0.5	0.4	-0.4	-0.4	-0.4
Time in novel zone, NPP test	0.0	0.0	0.0	-0.1	-0.0	0.2	0.1	-0.1	-0.1	-0.1
Total zone transitions, NPP test	0.2	0.3	0.8	-0.7	-0.8	-0.9	-0.3	0.2	0.1	0.1
Total locomotion distance, NPP test	0.1	0.1	0.2	0.1	0.0	-0.0	0.4	-0.4	-0.5	-0.5
Locomotion velocity, NPP test	0.4	0.6	0.9	0.5	0.5	0.6	0.8	-0.9	-0.9	-0.9
Intraocular pressure	1.0	1.3	2.0	0.5	0.7	1.2	1.2	-1.4	-1.4	-1.4
Delta distance traveled before/after self-admin	2.4	2.6	2.9	-1.7	-1.7	-1.4	-1.7	1.6	1.6	1.6
Delta ambulatory time before/after self-admin	1.9	2.0	2.3	-1.5	-1.5	-1.2	-1.5	1.4	1.4	1.4
Parametrial fat weight	10.5	20.5	22.6	-4.5	-4.7	-4.8	-4.5	4.3	4.4	4.4
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.0	0.1	0.3	0.4	-0.6	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.8	1.1	1.4	-1.0	-0.9	-0.8	-1.1	1.2	1.1	1.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	0.7	0.6	0.5	0.4	-0.3	-0.3	-0.3
Pavlov. Cond. index score	0.8	1.1	1.4	-0.8	-0.8	-0.9	-1.1	1.2	1.2	1.2
Pavlov. Cond. latency score	1.0	1.3	1.8	-0.7	-0.8	-1.1	-1.2	1.3	1.3	1.3
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.1	-0.2	-0.4	-0.5	0.6	0.6	0.6
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	0.5	0.5	0.4	0.6	-0.6	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	0.2	0.2	0.1	0.6	-0.7	-0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.1	-0.8	-0.8	-0.7	-1.0	1.0	1.0	1.0
Pavlov. Cond. response bias	0.4	0.5	0.7	-0.6	-0.6	-0.6	-0.8	0.8	0.8	0.8
Pavlov. Cond. lever latency	1.4	1.8	2.6	-1.6	-1.5	-1.1	-1.4	1.3	1.2	1.2
Pavlov. Cond. magazine entry latency	0.3	0.3	1.3	1.1	0.9	-0.2	0.3	-0.2	-0.2	-0.2
Pavlov. Cond. change in total contacts	0.5	0.7	1.5	1.2	1.1	0.5	0.8	-0.7	-0.7	-0.7
Pavlov. Cond. index score	1.5	1.9	3.3	1.8	1.6	0.9	1.4	-1.3	-1.3	-1.3
Pavlov. Cond. latency score	2.0	2.5	3.9	2.0	1.8	1.1	1.6	-1.5	-1.5	-1.5
Pavlov. Cond. lever contacts	0.6	0.8	1.6	1.3	1.1	0.4	0.9	-0.8	-0.7	-0.7
Pavlov. Cond. magazine entry number	0.5	0.6	1.9	-1.4	-1.1	-0.3	-0.7	0.5	0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.8	-1.7	-1.5	-0.8	-1.0	0.8	0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	2.9	1.7	1.5	0.9	1.3	-1.2	-1.2	-1.2
Pavlov. Cond. response bias	0.7	0.9	2.1	1.4	1.3	0.5	0.9	-0.8	-0.7	-0.7
Time in closed arm before self-admin	3.2	3.6	4.0	-1.8	-1.9	-2.0	-1.8	1.9	1.9	1.9
Time in closed arm after self-admin	0.0	0.0	0.1	0.2	0.2	0.2	0.2	-0.1	-0.2	-0.2
Time in open arm before self-admin	5.5	6.0	7.6	2.7	2.8	2.5	2.3	-2.3	-2.2	-2.2
Time in open arm after self-admin	1.0	1.1	1.3	1.1	1.2	1.1	1.0	-1.0	-1.0	-1.0
Bone: periosteal estimation	0.2	0.5	0.7	0.9	0.8	0.6	0.7	-0.5	-0.6	-0.6
Bone: periosteal perimeter	0.3	0.5	0.7	0.5	0.6	0.8	0.8	-0.7	-0.8	-0.8
Bone: post-yield work	0.5	0.7	0.8	-0.7	-0.8	-0.9	-0.9	0.9	0.8	0.8
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.6	-0.5	-0.4	-0.4	0.2	0.3	0.3
Progressive ratio test 1 breakpoint	0.5	0.6	0.9	-0.9	-0.9	-0.8	-0.7	0.6	0.6	0.6
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.1	0.8	0.9	1.1	0.9	-0.9	-0.9	-0.9
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.3	-0.2	0.2	0.2	-0.3	-0.3	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.2	-0.1	0.3	0.3	-0.4	-0.4	-0.4
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.7	0.3	0.4	0.8	0.8	-0.9	-0.8	-0.8
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.0	0.0	0.3	0.3	-0.3	-0.3	-0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	0.0	0.1	0.3	0.3	-0.3	-0.3	-0.3
Sum of active levers in priming session hrs 5-6	3.2	3.1	3.2	-1.7	-1.8	-1.7	-1.8	1.8	1.8	1.8
Progressive ratio	0.2	0.2	0.4	-0.0	0.0	0.3	0.4	-0.6	-0.6	-0.6
Food seeking constrained by brief footshock	0.1	0.2	0.2	0.5	0.4	0.3	0.4	-0.3	-0.4	-0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.4	0.6	0.5	0.1	0.1	0.2	0.1	0.1
Retroperitoneal fat weight	0.0	0.0	0.1	0.1	0.0	-0.3	0.0	0.2	0.1	0.1
Reaction time number correct	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.4	0.3	0.4	0.4
Reaction time mean minus median	0.4	0.5	0.8	0.3	0.5	0.8	0.8	-0.7	-0.9	-0.9
Reaction time mean minus median AUC	0.1	0.2	0.4	-0.6	-0.4	0.2	0.2	-0.2	-0.4	-0.4
Reaction time num false alarms	0.7	0.9	1.5	0.4	0.5	0.8	1.0	-1.1	-1.2	-1.2
Reaction time num false alarms AUC	0.7	1.0	1.7	0.4	0.5	0.9	1.1	-1.2	-1.3	-1.3
Reaction time trials correct on left	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.4	0.3	0.4	0.4
Reaction time trials on left	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.3	0.3	0.3
Reaction time mean	0.2	0.3	0.4	0.3	0.4	0.6	0.5	-0.3	-0.6	-0.6
Reaction time mean AUC	0.6	0.8	1.1	0.6	0.7	1.1	0.9	-0.7	-1.1	-1.1
Median of all reaction times	0.2	0.3	0.4	0.5	0.5	0.6	0.5	-0.3	-0.6	-0.6
Reaction time omissions	0.0	0.0	0.0	0.0	0.1	0.2	0.0	-0.1	-0.0	-0.0
Reaction time false alarm rate	0.6	0.8	1.4	0.3	0.5	0.9	1.0	-1.0	-1.2	-1.2
Reaction time premature initiation rate	0.1	0.2	0.6	-0.8	-0.7	-0.2	-0.2	0.3	0.1	0.1
Reaction time premature initiations	0.2	0.3	0.8	-0.9	-0.8	-0.4	-0.4	0.4	0.2	0.2
Std. dev. reaction times	0.4	0.6	0.9	0.3	0.4	0.9	0.8	-0.7	-0.9	-0.9
Reaction time trials completed	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.3	0.3	0.3
Reaction time trials AUC	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.3	0.3	0.3
Run reversals in cocaine runway, females	0.9	0.9	1.5	0.7	0.8	0.9	1.0	-1.2	-1.0	-1.0
Run reversals in cocaine runway, males	0.3	0.3	0.5	0.0	0.2	0.6	0.6	-0.7	-0.7	-0.7
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.4	0.3	-0.1	0.1	-0.1	-0.1	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.2	0.0	-0.4	-0.2	0.3	0.2	0.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	0.2	0.3	0.3
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.5	-0.5	-0.4	-0.3	0.2	0.2	0.2
Total sessions with >9 infusions	0.0	0.0	0.1	-0.3	-0.3	-0.2	-0.3	-0.0	0.0	0.0
Short access day 1 total inactive lever presses	0.3	0.3	0.4	-0.6	-0.6	-0.5	-0.5	0.5	0.6	0.6
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.2	0.2	0.2	-0.0	0.2	0.2	0.2
Short access day 1 total infusions	1.2	1.3	1.9	0.6	0.8	1.3	1.1	-1.4	-1.3	-1.3
Short access day 10 total infusions	0.1	0.1	0.3	-0.5	-0.4	-0.0	-0.0	-0.3	-0.3	-0.3
Short access total infusions	0.4	0.5	0.8	0.0	0.2	0.7	0.6	-0.9	-0.9	-0.9
Short access day 1 locomotion	0.6	0.6	0.9	0.7	0.7	0.8	0.8	-0.9	-0.9	-0.9
Short access day 10 total locomotion	0.6	0.7	0.8	0.8	0.9	0.9	0.8	-0.8	-0.8	-0.8
Short access total locomotion	0.7	0.7	0.9	0.7	0.7	0.8	0.8	-1.0	-0.9	-0.9
One hour access (0.3 mA shock)	0.1	0.2	0.5	-0.7	-0.6	0.0	0.0	-0.3	-0.3	-0.3
Compulsive drug intake	0.4	0.4	0.6	-0.3	-0.4	-0.7	-0.8	0.6	0.7	0.7
One hour access (shock baseline)	0.1	0.2	0.3	-0.3	-0.2	0.3	0.4	-0.5	-0.5	-0.5
Social response proportion	4.5	4.9	5.5	-1.9	-2.0	-2.1	-2.3	2.3	2.3	2.3
Social responses	2.5	3.2	3.6	-1.7	-1.8	-1.9	-1.9	1.7	1.8	1.8
Social time	3.2	4.2	5.0	-2.2	-2.2	-2.1	-2.0	2.0	1.9	1.9
Soleus weight	4.7	13.8	15.7	-3.7	-3.8	-4.0	-3.7	3.6	3.6	3.6
Bone: stiffness	1.6	2.5	2.9	-1.3	-1.4	-1.7	-1.6	1.7	1.6	1.6
Tibialis anterior weight	4.8	16.3	29.1	-5.4	-5.2	-3.8	-3.7	3.1	3.2	3.2
Time to tail flick, vehicle, before self-admin	5.6	5.7	7.8	-2.8	-2.7	-2.3	-2.3	2.1	2.1	2.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.5	-0.4	-0.1	-0.0	-0.2	-0.2	-0.2
Time to tail flick, test, before self-admin	0.3	0.3	0.5	-0.7	-0.7	-0.5	-0.6	0.4	0.4	0.4
Time to tail flick, test, after self-admin	0.4	0.4	0.5	-0.6	-0.6	-0.6	-0.7	0.7	0.7	0.7
Delta time to tail flick, vehicle, before/after SA	2.3	2.3	2.6	1.2	1.4	1.6	1.5	-1.6	-1.6	-1.6
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.1	-0.0	0.3	0.1	-0.1	-0.1	-0.1
Tibia length	0.5	1.3	2.1	-0.0	-0.3	-1.2	-1.2	1.4	1.4	1.4
Ambulatory time before self-admin	1.3	1.3	2.8	1.7	1.5	0.8	1.1	-0.9	-0.9	-0.9
Ambulatory time after self-admin	0.9	1.0	1.4	-0.4	-0.6	-1.1	-1.1	1.2	1.2	1.2
Bone: tissue strength	0.9	0.8	2.0	1.4	1.3	0.7	0.8	-0.6	-0.6	-0.6
Total heroin consumption	4.8	5.6	6.3	-2.5	-2.5	-2.3	-2.4	2.3	2.3	2.3
Bone: trabecular number	2.7	4.1	7.0	-2.7	-2.5	-1.9	-1.8	1.7	1.7	1.7
Bone: trabecular spacing	0.6	0.7	1.1	1.0	1.0	0.9	0.8	-0.8	-0.8	-0.8
Bone: trabecular thickness	0.2	0.2	0.4	-0.6	-0.6	-0.5	-0.4	0.5	0.4	0.4
Bone: trabecular tissue density	1.8	2.6	3.6	1.9	1.9	1.6	1.6	-1.3	-1.4	-1.4
Water consumed over 24 hours	0.3	0.4	0.6	-0.0	-0.2	-0.7	-0.6	0.8	0.8	0.8
Number of responses in last shaping day	1.4	1.4	1.6	1.2	1.2	1.2	1.1	-1.3	-1.2	-1.2