Fau

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	NM_001160231.1	0.05	0.03	4.1e-03	0.01	0.01	0.01	0.01	9.5e-03	5.0e-02	4.2e-02	2.0e-02
2	Brain	intron excision ratio	chr1_212779567_212779814	0.03	0.02	6.4e-03	-0	0.01	0.01	-0	5.9e-01	2.6e-02	5.3e-02	6.9e-01
3	NAcc	gene expression	Fau	0.02	0.01	7.2e-04	0.03	0.02	0.02	0.02	6.3e-05	3.6e-04	2.3e-04	1.9e-04
4	Liver	intron excision ratio	chr1_212779567_212779814	0.06	0.05	9.4e-03	0.01	0	0	0.01	2.8e-02	1.4e-01	1.1e-01	5.5e-02
5	OFC	alternative TSS	XM_063287976.1	0.26	0.14	8.9e-03	0.07	-0.01	0.02	0.12	7.7e-03	7.7e-01	9.7e-02	8.0e-04
6	OFC	alternative TSS	XM_063287976.1	0.27	0.14	8.3e-03	0.08	-0.01	0.03	0.12	7.2e-03	7.0e-01	6.8e-02	8.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.7	2.6	0.7	1.6	-0.7	0.7	0.2	0.2
Area under the delay curve	0.4	0.4	1.3	-0.1	0.3	-0.2	0.1	-1.1	-1.1
BMI with tail	1.6	5.4	17.6	2.4	4.2	-2.1	2.1	0.4	0.4
BMI without tail	0.8	2.6	6.0	1.6	2.5	-1.8	1.6	-0.8	-0.8
Body weight	2.2	9.8	19.8	3.7	4.4	-3.5	3.5	0.0	0.0
Weight adjusted by age	0.9	1.4	2.5	1.6	1.2	-1.3	1.0	0.9	0.9
Bone surface	3.5	6.3	13.2	3.0	3.6	-2.3	2.3	1.7	1.7
Bone volume	1.5	2.7	6.0	1.6	2.5	-1.0	1.0	1.7	1.7
Breakpoint value in progressive ratio session	2.2	2.7	4.2	1.9	2.0	-1.7	1.6	1.2	1.2
Number of licking bursts	0.2	0.3	0.5	0.7	0.6	-0.4	0.4	0.5	0.5
Context. condit. distance diff. score	1.3	1.5	3.0	-1.7	-1.4	1.2	-1.3	-0.8	-0.8
Locomotion velocity, session 1	0.4	0.4	0.8	0.1	-0.1	-0.6	0.5	-0.9	-0.9
Locomotion distance, session 1	0.7	0.9	1.6	0.8	1.3	-1.1	1.0	-0.6	-0.6
Locomotion velocity, session 2	2.3	2.7	4.8	1.9	2.2	-1.8	2.0	0.1	0.1
Locomotion distance, session 2	0.9	1.2	1.8	1.1	1.3	-1.3	1.3	-0.6	-0.6
Locomotion velocity, session 3	0.2	0.2	0.3	-0.5	0.3	0.2	-0.2	-0.5	-0.5
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.1	-0.3	-0.3
Stereotopy head waving bouts, day 3	0.4	0.5	0.9	-0.8	-0.1	0.3	-0.6	-1.0	-1.0
Stereotopy head waving duration, day 3	0.3	0.4	0.9	-0.9	-0.4	0.6	-0.9	-0.2	-0.2
Locomotion velocity, session 7	0.2	0.2	0.4	-0.6	0.3	0.6	-0.5	-0.0	-0.0
Locomotion distance, session 7	0.4	0.5	1.2	-0.2	0.3	-0.3	0.4	-1.1	-1.1
Stereotopy head waving bouts, day 7	0.5	0.6	1.2	-0.1	0.3	0.5	-0.8	1.1	1.1
Stereotopy head waving duration, day 7	0.7	0.9	1.6	0.9	1.3	-0.4	0.2	1.2	1.2
Locomotion velocity, session 8	1.0	1.2	2.2	1.0	0.7	-1.5	1.5	-0.9	-0.9
Locomotion distance, session 8	0.1	0.1	0.3	-0.6	0.1	0.3	-0.4	-0.2	-0.2
Degree of sensitization distance	0.2	0.2	0.4	0.0	0.5	-0.3	0.4	-0.6	-0.6
Degree of sensitization stereotypy	0.8	0.9	2.1	0.7	0.9	-0.0	-0.1	1.4	1.4
Conditioned locomotion	1.3	1.5	2.4	1.5	1.4	-1.5	1.4	-0.4	-0.4
Cocaine response after cond. corrected	1.1	1.3	1.9	-1.4	-1.2	0.7	-0.8	-1.3	-1.3
Cocaine response after cond. not corrected	0.7	0.9	1.5	-1.2	-1.0	0.6	-0.8	-1.0	-1.0
Cocaine response before conditioning	0.8	0.9	1.8	0.9	0.9	-0.5	0.4	1.3	1.3
Saline control response	3.1	4.2	6.7	2.6	2.3	-2.6	2.5	-0.4	-0.4
Bone: connectivity density	1.7	2.7	6.8	1.8	2.6	-1.7	1.8	0.3	0.3
Bone: cortical apparent density	0.0	0.1	0.1	0.3	-0.2	-0.3	0.3	-0.2	-0.2
Bone: cortical area	0.5	0.8	1.3	1.0	1.1	-0.8	0.9	0.8	0.8
Bone: cortical porosity	0.2	0.2	0.4	0.5	0.6	-0.4	0.5	-0.2	-0.2
Bone: cortical porosity	0.5	0.6	1.1	0.9	1.0	-0.9	0.9	-0.2	-0.2
Bone: cortical thickness	1.9	3.1	6.0	2.1	1.4	-2.4	2.4	-0.5	-0.5
Bone: cortical thickness	0.9	1.1	1.7	0.6	0.1	-1.3	1.2	-1.2	-1.2
Bone: cortical tissue density	0.1	0.1	0.3	0.5	-0.1	-0.5	0.5	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	0.4	0.5	-0.6	0.3	-0.1	-0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.1	-0.0	-0.3	0.1	-0.1	-0.1
Condit. Reinf. active responses	0.1	0.1	0.2	0.1	0.5	-0.1	-0.0	0.4	0.4
Condit. Reinf. inactive responses	0.2	0.3	0.5	-0.3	0.3	0.6	-0.4	0.7	0.7
Incentive salience index mean	0.3	0.4	1.0	0.6	1.0	-0.7	0.5	0.0	0.0
Condit. Reinf. lever presses	0.5	0.7	1.7	0.7	1.3	-0.5	0.5	0.8	0.8
Condit. Reinf. active minus inactive responses	0.5	0.7	1.6	-0.3	-0.1	0.7	-0.6	1.3	1.3
Condit. Reinf. active-inactive response ratio	1.6	1.9	3.1	-0.9	-0.3	1.4	-1.4	1.8	1.8
Condit. Reinf. active responses	0.2	0.3	0.7	0.4	0.5	-0.0	0.1	0.9	0.9
Condit. Reinf. inactive responses	0.6	0.8	1.2	0.9	0.7	-1.1	1.1	-0.7	-0.7
Condit. Reinf. lever presses	1.5	2.1	3.3	1.7	1.8	-0.9	1.1	1.5	1.5
Condit. Reinf. lever reinforcers received	0.4	0.5	1.0	0.7	0.7	-0.3	0.4	1.0	1.0
Conditioned reinforcement - actives	0.9	1.6	4.4	0.2	-0.0	0.6	-0.6	2.1	2.1
Conditioned reinforcement - inactives	3.6	5.3	7.1	-2.2	-2.0	2.6	-2.7	2.2	2.2
Conditioned locomotion	6.4	8.3	13.0	-3.3	-3.4	3.6	-3.6	0.9	0.9
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.3	-0.0	0.0	-0.0	0.1	0.1
Patch foraging indifference point AUC	1.3	1.9	2.9	1.7	1.5	-1.2	1.4	1.2	1.2
Delay disc. indifference point, 0s delay	1.1	1.2	3.6	-0.4	0.1	0.1	-0.2	-1.9	-1.9
Delay disc. indifference point, 16s delay	0.6	0.6	1.1	-1.0	-0.6	1.0	-1.0	0.4	0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.4	0.1	0.4	-0.4	-0.2	-0.2
Delay disc. indifference point, 24s delay	0.5	0.5	1.5	-0.1	-0.4	-0.2	0.2	-1.2	-1.2
Delay disc. indifference point, 4s delay	0.8	0.9	2.5	-0.3	0.1	-0.3	0.2	-1.6	-1.6
Delay disc. indifference point, 8s delay	0.7	0.9	2.5	-0.1	0.1	-0.4	0.3	-1.6	-1.6
Indifference point function ln k	4.4	7.6	12.2	-3.5	-3.2	2.5	-2.7	-2.1	-2.1
Indifference point function log k	4.4	7.6	12.2	-3.5	-3.2	2.5	-2.7	-2.1	-2.1
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.2	-0.4	-0.4
Patch foraging total patch changes 12 sec	3.0	4.0	6.3	2.5	2.4	-2.3	2.4	0.5	0.5
Patch foraging total patch changes 18 sec	0.4	0.5	1.2	0.8	1.1	-0.6	0.8	0.5	0.5
Patch foraging total patch changes 24 sec	1.0	1.7	3.2	1.6	1.3	-1.6	1.8	0.2	0.2
Patch foraging total patch changes 6 sec	0.9	1.3	2.4	1.0	1.3	-1.4	1.6	-0.7	-0.7
Patch foraging time to switch 0 sec	1.3	2.7	6.4	1.7	2.5	-1.1	1.0	1.5	1.5
Patch foraging water rate 0 sec	2.4	5.1	11.7	-2.6	-3.4	2.4	-2.2	-1.0	-1.0
Patch foraging water rate 12 sec	5.1	10.7	20.8	-3.7	-4.6	2.8	-2.9	-2.6	-2.6
Patch foraging water rate 18 sec	2.4	3.7	5.4	-2.0	-2.3	1.4	-1.5	-2.1	-2.1
Patch foraging water rate 24 sec	3.1	4.4	8.5	-2.4	-2.9	2.0	-2.0	-1.5	-1.5
Patch foraging water rate 6 sec	4.2	6.1	10.2	-2.6	-3.2	1.7	-1.6	-2.7	-2.7
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.3	-0.1	0.3	-0.4	0.1	0.1
Distance traveled before self-admin	0.7	1.0	1.5	0.9	1.2	-0.5	0.4	1.2	1.2
Distance traveled after self-admin	0.4	0.5	1.3	0.4	0.4	-0.3	0.3	1.1	1.1
Extensor digitorum longus weight	5.5	21.8	34.5	5.9	5.9	-5.6	5.5	0.5	0.5
Bone: elastic displacement	1.4	1.7	3.0	-1.0	-1.7	0.4	-0.3	-1.7	-1.7
Bone: elastic work	1.5	2.0	2.7	1.0	0.6	-1.6	1.7	-1.6	-1.6
Bone: endosteal estimation	0.4	0.9	2.0	-1.2	0.1	1.4	-1.3	0.4	0.4
Bone: endosteal perimeter	1.0	2.0	3.7	-1.4	-0.1	1.9	-1.8	1.3	1.3
Epididymis fat weight	2.4	8.2	14.8	-3.3	-2.8	3.8	-3.6	1.1	1.1
Delta time in closed arm before/after self-admin	1.9	1.8	3.9	0.3	0.3	-1.2	1.1	-2.0	-2.0
Delta time in open arm before/after self-admin	1.3	1.3	3.7	0.4	0.4	0.2	-0.3	1.9	1.9
Diff in mean of infusions in LGA sessions	0.4	0.5	0.7	0.8	0.6	-0.8	0.8	0.6	0.6
Delay discount exponential model param	0.4	0.4	1.1	0.1	-0.3	0.3	-0.2	1.0	1.0
Extinction: sum of active levers before priming	2.0	2.2	4.3	1.6	2.1	-1.6	1.5	1.0	1.0
Active lever presses in extinction session 6	2.8	2.8	4.1	2.0	2.0	-1.4	1.4	1.6	1.6
Bone: final force	1.8	2.9	5.3	2.1	2.3	-1.9	1.8	0.7	0.7
Bone: final moment	1.7	2.7	5.0	2.0	2.2	-1.8	1.7	0.6	0.6
Food consumed during 24 hour testing period	0.3	0.4	1.2	0.3	-0.3	0.2	-0.1	1.1	1.1
Glucose	1.3	2.1	4.2	-2.0	-1.0	1.8	-1.9	-0.5	-0.5
Heart weight	1.3	2.0	4.9	-1.2	-0.1	0.5	-0.5	-2.2	-2.2
Delay discount hyperbolic model param	0.3	0.3	1.0	0.1	-0.3	0.2	-0.1	1.0	1.0
Intermittent access intake day 1-15 change	1.2	2.5	3.2	-1.4	-1.5	1.8	-1.6	1.6	1.6
Intermittent access intake escalation	1.2	2.5	3.2	-1.3	-1.4	1.7	-1.6	1.8	1.8
Intermittent access intake escalation 2	1.9	2.2	2.8	-1.2	-1.3	1.6	-1.5	1.7	1.7
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.4	-0.6	-0.6	0.5	-0.6	0.6	0.6
Intermitt. access day 15 inactive lever presses	1.7	3.4	4.7	-1.7	-1.3	2.0	-2.2	1.8	1.8
Intermitt. access escalation Index	2.0	2.8	4.2	-2.1	-1.8	1.7	-1.7	-1.3	-1.3
Intermittent access day 1 total infusions	1.5	2.4	4.8	-1.8	-0.7	2.2	-2.1	0.7	0.7
Intermittent access day 15 total infusions	4.8	7.2	11.5	-2.8	-2.2	3.4	-3.3	2.0	2.0
Intermittent access terminal intake (last 3 days)	4.6	6.1	10.0	-2.5	-1.7	3.2	-3.1	2.1	2.1
Intermittent access total infusions	3.3	3.9	7.1	-2.1	-1.2	2.7	-2.6	1.3	1.3
Intermittent access day 1 locomotion	1.4	1.8	3.5	-1.7	-0.8	1.9	-1.8	0.5	0.5
Intermittent access day 15 total locomotion	3.9	7.2	10.4	-2.6	-1.8	3.2	-3.2	2.5	2.5
Intermittent access total locomotion	7.1	8.5	13.7	-3.0	-1.8	3.7	-3.7	2.4	2.4
Intermittent access standard deviation	0.8	1.7	2.7	-1.5	-1.5	1.6	-1.6	0.4	0.4
Left kidney weight	0.4	2.0	3.6	-1.7	-1.0	1.9	-1.9	0.8	0.8
Right kidney weight	0.2	1.0	1.8	-1.1	-1.0	1.4	-1.3	0.5	0.5
Cocaine induced anxiety	0.4	0.5	1.5	0.1	0.2	0.0	-0.1	1.2	1.2
Post-drug Anxiety	0.8	0.8	1.1	0.9	0.9	-0.7	0.7	1.0	1.0
Baseline Anxiety	0.7	0.8	1.2	0.6	0.4	-0.9	1.0	-1.1	-1.1
Tail length	0.5	1.8	3.1	1.4	0.6	-1.8	1.7	-1.0	-1.0
Length with tail	1.5	6.4	11.0	3.1	2.4	-3.3	3.3	-0.9	-0.9
Length without tail	1.7	5.5	9.6	2.7	2.0	-3.0	3.1	-1.2	-1.2
Times rat made contact with spout	0.5	0.5	1.0	0.8	0.6	-1.0	1.0	-0.4	-0.4
Lifetime Intake	2.0	2.4	4.7	-1.8	-1.0	2.2	-2.1	0.7	0.7
Liver weight, left	0.6	1.0	1.5	-1.2	-1.1	0.8	-0.8	-1.0	-1.0
Liver weight, right	1.7	3.0	4.2	-2.1	-1.8	1.2	-1.2	-1.9	-1.9
Locomotor activity	2.2	3.4	5.4	-1.8	-2.3	1.2	-1.0	-2.1	-2.1
Locomotor testing distance	2.7	4.9	8.0	-2.0	-2.6	1.2	-1.0	-2.8	-2.8
Locomotor testing rearing	2.0	4.0	5.9	-2.0	-2.4	1.2	-1.1	-2.4	-2.4
Locomotion in novel chamber	3.7	4.7	7.9	-2.6	-2.4	2.8	-2.7	0.6	0.6
Locomotion in novel chamber post-restriction	2.1	3.5	6.1	-2.2	-2.0	2.5	-2.3	0.6	0.6
Fecal boli incidents, locomotor time 1	0.9	1.4	3.6	-0.1	0.2	0.6	-0.6	1.9	1.9
Change in fecal boli incidents, locomotor task	0.8	0.8	2.0	0.1	0.1	-0.5	0.6	-1.4	-1.4
Time >=10cm from walls, locomotor time 1	1.3	1.3	1.9	-0.9	0.3	1.3	-1.4	1.3	1.3
Bouts of movement, locomotor time 1	1.0	1.1	2.6	1.6	0.7	-1.0	1.0	0.9	0.9
Total resting periods, locomotor time 1	0.8	0.9	1.5	1.2	0.6	-0.6	0.7	1.1	1.1
Rest time, locomotor task time 1	1.1	1.3	2.4	-1.2	-1.4	1.6	-1.4	0.2	0.2
Distance moved, locomotor task time 1	0.2	0.3	0.6	0.2	0.8	-0.4	0.4	-0.5	-0.5
Vertical activity count, locomotor time 1	0.3	0.7	1.5	-1.2	-1.0	0.9	-1.0	-0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	0.3	0.4	0.2	-0.3	0.7	0.7
Bouts of movement, locomotor time 2	0.2	0.4	0.6	0.8	0.5	-0.6	0.7	0.5	0.5
Total resting periods, locomotor time 2	0.1	0.2	0.3	0.4	0.4	-0.2	0.4	0.5	0.5
Rest time, locomotor task time 2	1.4	1.7	3.0	-1.6	-1.4	1.7	-1.6	-0.3	-0.3
Distance moved, locomotor task time 2	0.8	1.0	1.8	1.3	0.9	-1.3	1.2	-0.4	-0.4
Vertical activity count, locomotor time 2	0.2	0.3	0.5	-0.0	-0.7	-0.3	0.3	-0.7	-0.7
Light reinforcement 1	0.1	0.1	0.3	-0.4	-0.6	0.1	-0.1	-0.4	-0.4
Light reinforcement 2	1.1	1.7	2.4	-1.0	-0.8	1.5	-1.5	1.4	1.4
Bone: marrow area	0.4	0.9	2.0	-1.2	0.1	1.4	-1.3	0.3	0.3
Bone: maximum diameter	0.6	1.1	2.9	0.5	0.8	0.1	0.1	1.7	1.7
Bone: maximum force	2.5	4.5	10.0	2.5	3.2	-2.0	2.0	1.3	1.3
Bone: maximum moment	2.3	4.1	9.2	2.3	3.0	-1.9	1.9	1.1	1.1
Mean time between licks in bursts	0.7	1.6	2.9	0.6	0.3	-1.3	1.3	-1.7	-1.7
Mean num. licks in bursts	0.2	0.3	0.5	-0.5	-0.6	0.2	-0.1	-0.7	-0.7
Cd content in liver	2.2	2.4	3.1	-1.2	-1.1	1.8	-1.7	1.7	1.7
Co content in liver	1.6	1.9	4.2	-1.2	-2.0	0.6	-0.6	-1.6	-1.6
Cu content in liver	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2	-0.1	-0.1
Fe content in liver	0.1	0.2	0.2	0.4	0.3	-0.5	0.4	-0.4	-0.4
K content in liver	0.6	0.6	1.2	0.5	1.1	-0.8	0.9	-0.6	-0.6
Mg content in liver	0.5	0.5	1.2	-0.7	-0.3	0.3	-0.3	-1.1	-1.1
Mn content in liver	2.3	2.5	4.6	2.1	2.0	-1.5	1.5	1.0	1.0
Na content in liver	0.2	0.2	0.5	0.6	0.4	-0.7	0.6	-0.0	-0.0
Rb content in liver	1.7	1.9	3.1	-1.8	-1.5	1.1	-1.2	-1.4	-1.4
Se content in liver	0.5	0.6	0.9	-0.3	-0.3	0.8	-0.9	1.0	1.0
Sr content in liver	1.9	1.6	3.0	1.7	1.1	-1.4	1.6	0.7	0.7
Zn content in liver	0.3	0.3	0.7	0.5	0.6	-0.8	0.6	-0.3	-0.3
Bone: minimum diameter	0.4	0.8	1.7	-1.1	0.1	1.3	-1.3	0.4	0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.5	-0.2	0.5	-0.5	0.1	0.1
Time in novel zone, hab. session 1	0.6	0.6	1.4	-0.3	-0.8	-0.1	0.1	-1.2	-1.2
Total zone transitions, hab. session 1	0.5	0.7	1.0	1.0	1.0	-0.9	0.9	0.4	0.4
Total locomotion distance, hab. session 1	0.1	0.2	0.4	-0.6	-0.0	0.5	-0.6	0.1	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.1	0.3	0.1	-0.2	0.2	0.2
Time in familiar zone, hab. session 2	0.7	0.7	1.7	-0.2	-0.3	-0.6	0.5	-1.3	-1.3
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.4	0.5	0.1	-0.1	0.6	0.6
Total zone transitions, hab. session 2	1.4	1.8	4.3	1.5	2.1	-1.5	1.4	-0.0	-0.0
Total locomotion distance, hab. session 2	0.2	0.2	0.7	0.1	0.8	-0.3	0.2	-0.5	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.5	-0.2	0.7	0.1	-0.2	-0.1	-0.1
Novel to familiar place preference ratio	1.7	1.8	4.0	1.1	1.3	-0.3	0.3	2.0	2.0
Novelty place preference	1.2	1.3	3.1	0.7	0.8	-0.0	-0.0	1.8	1.8
Time in novel zone, NPP test	0.8	0.9	2.1	0.6	0.7	-0.0	0.0	1.5	1.5
Total zone transitions, NPP test	1.9	2.7	4.9	2.0	2.2	-1.8	1.8	0.6	0.6
Total locomotion distance, NPP test	0.1	0.2	0.6	0.3	0.8	-0.4	0.4	-0.2	-0.2
Locomotion velocity, NPP test	0.1	0.2	0.6	0.4	0.8	-0.4	0.3	0.1	0.1
Intraocular pressure	2.1	3.0	3.6	-1.3	-1.6	1.8	-1.9	1.9	1.9
Delta distance traveled before/after self-admin	0.3	0.3	0.7	-0.5	-0.9	-0.0	0.1	-0.6	-0.6
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.2	-0.6	-0.3	0.4	-0.6	-0.6
Parametrial fat weight	2.4	5.8	10.8	-3.0	-2.0	3.1	-3.3	0.6	0.6
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.6	-0.9	0.5	-0.5	-0.1	-0.1
Pavlov. Cond. magazine entry latency	0.4	0.5	1.3	0.8	1.1	-0.3	0.1	0.7	0.7
Pavlov. Cond. change in total contacts	0.9	0.9	2.3	0.4	0.7	0.3	-0.4	1.5	1.5
Pavlov. Cond. index score	0.3	0.3	0.5	0.7	0.7	-0.2	0.1	0.7	0.7
Pavlov. Cond. latency score	0.2	0.2	0.5	0.6	0.7	-0.2	0.1	0.4	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.5	0.4	0.7	-0.3	0.3	-0.1	-0.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	-0.8	-0.6	0.2	-0.1	-1.0	-1.0
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.3	-1.0	-1.1	1.1	-1.1	0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	0.9	1.0	-0.4	0.2	0.8	0.8
Pavlov. Cond. response bias	0.3	0.3	0.6	0.6	0.6	-0.2	0.0	0.8	0.8
Pavlov. Cond. lever latency	0.6	0.9	1.7	-0.9	-1.0	0.3	-0.3	-1.3	-1.3
Pavlov. Cond. magazine entry latency	3.1	3.7	6.7	2.4	2.6	-2.0	2.0	0.9	0.9
Pavlov. Cond. change in total contacts	1.8	2.9	5.7	1.6	1.8	-0.6	0.5	2.4	2.4
Pavlov. Cond. index score	2.0	2.6	4.6	1.9	2.1	-1.2	1.1	1.6	1.6
Pavlov. Cond. latency score	1.8	2.4	4.0	1.7	2.0	-1.0	1.0	1.6	1.6
Pavlov. Cond. lever contacts	0.6	0.9	1.6	0.9	1.0	-0.4	0.3	1.3	1.3
Pavlov. Cond. magazine entry number	4.9	6.0	10.1	-3.2	-3.1	2.4	-2.4	-1.5	-1.5
Pavlov. Cond. intertrial magazine entries	0.7	1.1	1.8	-1.3	-1.2	1.2	-1.3	0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.3	3.1	5.3	2.1	2.3	-1.4	1.3	1.6	1.6
Pavlov. Cond. response bias	1.5	2.1	3.6	1.8	1.9	-1.1	1.1	1.3	1.3
Time in closed arm before self-admin	0.6	0.8	1.2	-0.5	-0.2	1.1	-1.0	1.1	1.1
Time in closed arm after self-admin	0.2	0.2	0.5	-0.7	-0.5	0.3	-0.3	-0.4	-0.4
Time in open arm before self-admin	3.2	3.5	9.7	-0.4	-0.7	-0.7	0.7	-3.1	-3.1
Time in open arm after self-admin	0.3	0.4	0.7	0.4	-0.0	-0.5	0.5	-0.8	-0.8
Bone: periosteal estimation	0.2	0.5	1.0	-0.0	0.8	0.4	-0.3	1.0	1.0
Bone: periosteal perimeter	0.3	0.5	1.0	0.4	1.0	0.0	0.1	0.9	0.9
Bone: post-yield work	1.9	2.8	7.1	0.9	2.7	0.1	0.0	2.1	2.1
Progressive ratio test 1 active lever presses	0.4	0.5	0.8	-0.5	-0.4	0.9	-0.9	0.7	0.7
Progressive ratio test 1 breakpoint	0.4	0.5	0.7	-0.4	-0.3	0.9	-0.8	0.8	0.8
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.5	-0.4	-0.4	0.5	-0.6	0.7	0.7
Progressive ratio test 2 active lever presses	3.0	3.5	5.4	-1.7	-1.4	2.3	-2.3	1.7	1.7
Progressive ratio test 2 breakpoint	3.1	3.5	5.4	-1.7	-1.4	2.3	-2.3	1.7	1.7
Progressive ratio test 2 inactive lever presses	5.7	9.3	15.3	-3.3	-2.9	3.9	-3.9	1.7	1.7
Incentive Sensitization - Responses	0.4	0.6	1.6	-0.1	0.3	0.5	-0.4	1.2	1.2
Incentive Sensitization - Breakpoint	0.5	0.7	1.6	-0.3	0.1	0.7	-0.6	1.2	1.2
Sum of active levers in priming session hrs 5-6	3.6	3.4	9.6	1.0	0.4	-0.1	0.1	3.1	3.1
Progressive ratio	0.9	1.4	4.9	1.5	2.2	-0.9	0.7	0.4	0.4
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.2	0.1	-0.3	0.4	-0.4	-0.4
Seeking ratio, punishment vs. effort	1.5	2.1	4.9	-1.7	-2.2	0.8	-0.6	-1.4	-1.4
Retroperitoneal fat weight	6.3	26.8	45.5	-6.7	-5.9	6.1	-6.3	-1.4	-1.4
Reaction time number correct	0.1	0.2	0.4	0.6	0.2	-0.6	0.6	-0.3	-0.3
Reaction time mean minus median	1.7	4.3	6.3	2.5	2.4	-1.6	1.7	2.0	2.0
Reaction time mean minus median AUC	0.7	1.9	3.3	1.8	1.5	-1.2	1.3	1.2	1.2
Reaction time num false alarms	1.4	1.9	4.9	-0.9	-0.9	-0.2	0.0	-2.2	-2.2
Reaction time num false alarms AUC	1.1	1.7	4.7	-0.2	-0.3	-0.8	0.6	-2.2	-2.2
Reaction time trials correct on left	0.1	0.2	0.4	0.6	0.2	-0.6	0.6	-0.3	-0.3
Reaction time trials on left	0.2	0.3	0.6	0.7	0.3	-0.7	0.7	-0.3	-0.3
Reaction time mean	0.4	0.7	1.9	0.3	0.3	0.1	-0.3	1.4	1.4
Reaction time mean AUC	0.5	0.7	2.0	0.2	0.3	0.3	-0.4	1.4	1.4
Median of all reaction times	0.4	0.6	1.1	-0.4	-0.2	0.6	-0.8	1.0	1.0
Reaction time omissions	1.1	1.6	3.2	1.8	1.6	-1.3	1.3	0.6	0.6
Reaction time false alarm rate	1.0	1.4	3.6	-0.8	-0.6	-0.1	-0.0	-1.9	-1.9
Reaction time premature initiation rate	3.6	5.0	7.5	2.0	1.5	-2.6	2.7	-2.1	-2.1
Reaction time premature initiations	3.4	6.0	9.9	2.6	1.7	-3.0	3.1	-1.9	-1.9
Std. dev. reaction times	0.8	1.4	2.1	1.3	1.2	-0.7	0.7	1.5	1.5
Reaction time trials completed	0.2	0.3	0.6	0.7	0.3	-0.7	0.7	-0.3	-0.3
Reaction time trials AUC	0.1	0.2	0.4	0.5	0.2	-0.6	0.6	-0.4	-0.4
Run reversals in cocaine runway, females	1.7	1.7	3.2	0.4	1.1	-1.0	1.1	-1.8	-1.8
Run reversals in cocaine runway, males	0.4	0.4	1.3	-0.7	-1.1	0.5	-0.5	-0.3	-0.3
Latency to leave start box in cocaine runway	0.1	0.2	0.2	-0.3	0.4	0.4	-0.4	0.5	0.5
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.1	0.2	0.2	-0.2	-0.1	-0.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.1	0.5	-0.0	-0.0	0.6	0.6
Std. dev. time between licks in bursts	1.2	1.6	4.3	-0.1	-0.4	-0.7	0.6	-2.1	-2.1
Total sessions with >9 infusions	0.1	0.1	0.3	0.0	0.5	0.2	-0.1	0.2	0.2
Short access day 1 total inactive lever presses	1.6	2.1	4.0	-2.0	-1.5	1.8	-1.7	-0.1	-0.1
Short access day 10 total inactive lever presses	0.3	0.7	1.3	-1.1	-1.0	0.5	-0.6	-0.7	-0.7
Short access day 1 total infusions	0.8	1.1	2.1	-1.4	-0.7	1.5	-1.4	-0.1	-0.1
Short access day 10 total infusions	0.5	0.6	1.0	-0.7	0.5	1.0	-0.9	0.8	0.8
Short access total infusions	0.2	0.3	0.7	-0.7	0.2	0.8	-0.7	-0.1	-0.1
Short access day 1 locomotion	1.1	1.4	2.5	-1.6	-1.0	1.5	-1.5	0.3	0.3
Short access day 10 total locomotion	0.7	1.2	2.2	-1.2	-0.5	1.5	-1.4	0.8	0.8
Short access total locomotion	1.2	1.4	2.7	-1.4	-0.7	1.6	-1.5	0.7	0.7
One hour access (0.3 mA shock)	5.1	5.9	9.9	-3.0	-2.6	3.2	-3.1	0.1	0.1
Compulsive drug intake	3.3	3.9	5.7	1.5	0.7	-2.2	2.2	-2.4	-2.4
One hour access (shock baseline)	5.6	8.6	14.5	-3.2	-2.6	3.8	-3.7	1.7	1.7
Social response proportion	0.6	0.7	1.0	0.8	0.8	-0.6	0.5	1.0	1.0
Social responses	0.1	0.2	0.4	0.5	0.2	-0.6	0.5	-0.0	-0.0
Social time	0.2	0.3	0.7	0.7	0.3	-0.8	0.8	-0.3	-0.3
Soleus weight	2.8	8.2	14.1	-3.8	-3.4	3.3	-3.4	-0.6	-0.6
Bone: stiffness	2.1	3.3	7.0	2.1	2.6	-1.5	1.4	1.5	1.5
Tibialis anterior weight	6.8	23.0	39.9	6.3	5.5	-5.7	5.7	1.1	1.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.7	0.6	0.9	-0.4	0.3	-0.1	-0.1
Time to tail flick, vehicle, after self-admin	1.0	1.3	2.8	0.8	1.7	-1.0	1.0	-1.0	-1.0
Time to tail flick, test, before self-admin	1.7	1.7	2.3	-1.5	-0.7	1.2	-1.2	-1.5	-1.5
Time to tail flick, test, after self-admin	0.2	0.2	0.7	0.3	0.2	0.1	-0.0	0.8	0.8
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.9	0.5	0.9	-0.8	0.8	-0.5	-0.5
Delta time to tail flick, test, before/after SA	1.6	1.6	2.6	1.5	0.4	-1.0	1.0	1.6	1.6
Tibia length	1.5	4.1	9.6	1.6	1.5	-0.6	0.5	3.1	3.1
Ambulatory time before self-admin	0.9	1.3	3.1	0.7	1.1	-0.1	0.0	1.8	1.8
Ambulatory time after self-admin	0.8	1.0	2.2	-0.6	-0.2	0.7	-0.8	1.5	1.5
Bone: tissue strength	0.0	0.0	0.1	0.1	0.1	0.2	0.0	0.3	0.3
Total heroin consumption	3.6	4.3	7.1	2.7	2.5	-2.4	2.4	0.7	0.7
Bone: trabecular number	0.7	1.2	3.0	0.9	1.7	-0.6	0.7	1.2	1.2
Bone: trabecular spacing	0.5	0.7	1.3	-0.7	-1.0	0.2	-0.3	-1.2	-1.2
Bone: trabecular thickness	0.2	0.3	0.6	-0.8	-0.2	0.8	-0.7	0.1	0.1
Bone: trabecular tissue density	3.2	4.7	7.6	-2.6	-2.6	2.6	-2.8	0.2	0.2
Water consumed over 24 hours	0.7	1.0	1.8	1.3	0.7	-1.4	1.3	-0.2	-0.2
Number of responses in last shaping day	0.2	0.3	0.7	-0.1	-0.3	-0.1	0.1	-0.8	-0.8