Rpa1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Rpa1	0.13	0.08	3.3e-12	0.09	0.08	0.08	0.09	3.7e-10	5.2e-09	6.8e-09	1.2e-09
2	pVTA	gene expression	Rpa1	0.13	0.09	2.5e-09	0.13	0.06	0.13	0.03	7.7e-11	9.8e-06	1.6e-10	9.2e-04
3	PL	gene expression	Rpa1	0.04	0.04	9.7e-05	0.03	0.03	0.02	0.02	3.8e-04	2.9e-04	4.6e-03	9.8e-04
4	Adipose	isoform ratio	NM_001394069.1	0.06	0.05	2.1e-05	0.03	0.04	0.03	0.03	5.9e-04	8.7e-05	2.5e-04	1.7e-04
5	Adipose	alternative TSS	NM_001394069.1	0.06	0.05	2.7e-05	0.02	0.03	0.03	0.03	1.6e-03	9.6e-05	2.7e-04	2.1e-04
6	Adipose	isoform ratio	XM_063268676.1	0.06	0.04	1.2e-04	0.02	0.02	0.01	0.02	6.6e-03	1.6e-03	9.0e-03	3.8e-03
7	NAcc	gene expression	Rpa1	0.04	0.03	8.1e-05	0.02	0.02	0.02	0.02	6.5e-04	1.6e-04	2.7e-04	3.8e-04
8	Adipose	alternative TSS	XM_063268676.1	0.06	0.05	8.3e-05	0.02	0.03	0.02	0.02	2.8e-03	7.7e-04	3.4e-03	1.6e-03
9	PL	alternative TSS	XM_063268676.1	0.06	0.04	3.8e-05	0.04	0.03	0.03	0.03	9.5e-05	3.2e-04	5.6e-04	1.6e-04
10	Adipose	gene expression	Rpa1	0.11	0.07	2.5e-07	0.03	0.04	0.04	0.03	9.3e-05	2.7e-05	6.7e-05	1.8e-04
11	IC	mRNA stability	Rpa1	0.08	0.06	8.4e-03	0.08	0.02	0.04	0.05	3.1e-04	5.1e-02	1.2e-02	3.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	2.7	5.1	9.1	-3.0	3.0	3.0	2.2	2.2	-2.0	-1.9	-1.9	-1.3	-1.4	-2.1
Area under the delay curve	0.7	1.0	2.0	1.4	-1.2	-1.3	-1.1	-1.1	1.0	1.0	0.9	0.8	0.8	0.4
BMI with tail	0.8	2.7	4.5	-2.0	2.1	2.0	1.7	1.7	-1.5	-1.5	-1.5	-1.1	-1.2	-1.4
BMI without tail	0.3	1.4	6.5	-1.0	1.1	2.3	0.1	0.1	0.2	0.2	0.3	0.9	0.7	-2.6
Body weight	0.8	3.7	16.1	-0.9	1.0	3.1	-0.6	-0.7	1.1	1.1	1.2	2.2	1.8	-4.0
Weight adjusted by age	0.3	0.8	1.0	-1.0	1.0	0.6	1.0	1.0	-1.0	-1.0	-1.0	-0.9	-0.9	0.0
Bone surface	3.0	5.9	9.5	-3.1	3.1	2.8	2.6	2.5	-2.3	-2.3	-2.3	-1.8	-1.9	-1.6
Bone volume	3.0	5.9	9.4	-3.1	3.1	2.8	2.6	2.5	-2.3	-2.3	-2.3	-1.7	-1.9	-1.7
Breakpoint value in progressive ratio session	0.2	0.4	1.9	-0.8	0.7	1.4	0.2	0.1	0.0	0.0	0.1	0.4	0.3	-1.0
Number of licking bursts	0.1	0.4	1.6	0.8	-0.8	-0.8	-0.5	-0.5	0.4	0.4	0.4	0.3	0.3	1.3
Context. condit. distance diff. score	0.7	0.8	2.0	-1.2	1.2	1.4	0.8	0.8	-0.7	-0.6	-0.6	-0.3	-0.4	-1.1
Locomotion velocity, session 1	1.3	1.4	5.0	-1.5	1.5	2.2	0.8	0.8	-0.6	-0.5	-0.5	0.1	-0.1	-2.1
Locomotion distance, session 1	0.8	1.0	1.4	-1.2	1.2	0.9	1.1	1.1	-1.0	-1.0	-1.0	-0.9	-0.9	-0.4
Locomotion velocity, session 2	0.6	0.7	1.3	-1.1	1.1	1.1	0.8	0.8	-0.7	-0.7	-0.7	-0.5	-0.6	-0.8
Locomotion distance, session 2	1.6	2.3	3.6	-1.9	1.9	1.5	1.6	1.6	-1.5	-1.5	-1.5	-1.3	-1.3	-0.7
Locomotion velocity, session 3	4.0	4.6	6.9	2.6	-2.6	-2.3	-2.3	-2.3	2.1	2.1	2.1	1.7	1.8	1.2
Locomotion distance, session 3	0.2	0.2	0.3	-0.2	0.2	-0.2	0.4	0.4	-0.4	-0.4	-0.5	-0.6	-0.5	0.5
Stereotopy head waving bouts, day 3	0.3	0.4	0.8	0.5	-0.5	0.1	-0.6	-0.6	0.7	0.6	0.7	0.9	0.7	-0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.5	-0.5	-0.5	-0.1	-0.1	0.0	0.0	0.0	0.1	-0.1	0.5
Locomotion velocity, session 7	1.1	1.2	1.7	-1.3	1.3	0.9	1.2	1.2	-1.2	-1.2	-1.2	-1.0	-1.0	-0.3
Locomotion distance, session 7	1.6	2.0	2.9	-1.7	1.7	1.3	1.5	1.5	-1.5	-1.4	-1.4	-1.2	-1.3	-0.6
Stereotopy head waving bouts, day 7	0.4	0.5	1.5	-0.8	0.8	1.2	0.6	0.6	-0.5	-0.5	-0.4	0.0	-0.3	-1.0
Stereotopy head waving duration, day 7	0.9	1.1	1.9	-1.2	1.2	1.4	1.1	1.1	-1.0	-1.0	-0.9	-0.5	-0.8	-0.9
Locomotion velocity, session 8	0.6	0.7	1.0	-1.0	1.0	0.7	0.9	0.9	-0.9	-0.9	-0.9	-0.8	-0.8	-0.2
Locomotion distance, session 8	1.3	1.9	4.5	-1.9	1.9	2.1	1.2	1.2	-1.0	-1.0	-0.9	-0.5	-0.6	-1.7
Degree of sensitization distance	0.4	0.5	1.5	-0.9	0.9	1.2	0.4	0.4	-0.3	-0.3	-0.2	0.1	-0.0	-1.2
Degree of sensitization stereotypy	0.6	0.7	2.0	-1.0	1.0	1.4	0.7	0.7	-0.6	-0.6	-0.5	-0.1	-0.3	-1.2
Conditioned locomotion	0.1	0.2	0.7	0.4	-0.4	-0.8	-0.1	-0.1	-0.0	-0.1	-0.1	-0.2	-0.2	0.9
Cocaine response after cond. corrected	0.1	0.2	0.4	0.1	-0.1	0.3	-0.4	-0.4	0.4	0.4	0.5	0.6	0.6	-0.5
Cocaine response after cond. not corrected	0.1	0.2	0.7	-0.3	0.3	0.8	-0.1	-0.1	0.2	0.2	0.2	0.5	0.4	-0.8
Cocaine response before conditioning	0.8	0.9	1.7	-1.2	1.3	1.3	1.0	0.9	-0.9	-0.8	-0.8	-0.5	-0.6	-0.9
Saline control response	0.6	0.9	1.1	-1.0	1.0	0.6	1.1	1.1	-1.0	-1.1	-1.0	-0.9	-1.0	0.0
Bone: connectivity density	4.7	7.6	12.7	-3.5	3.6	3.3	2.8	2.8	-2.6	-2.5	-2.5	-1.9	-2.0	-2.1
Bone: cortical apparent density	0.2	0.3	1.2	0.3	-0.3	-0.9	0.2	0.3	-0.4	-0.4	-0.4	-0.7	-0.6	1.1
Bone: cortical area	1.4	2.2	3.3	1.8	-1.8	-1.7	-1.6	-1.6	1.5	1.5	1.4	1.0	1.2	1.0
Bone: cortical porosity	0.1	0.1	0.3	-0.2	0.2	0.5	0.1	0.1	-0.0	-0.0	0.0	0.2	0.1	-0.5
Bone: cortical porosity	0.1	0.1	0.2	0.2	-0.2	0.1	-0.3	-0.3	0.3	0.3	0.3	0.4	0.3	-0.2
Bone: cortical thickness	5.5	9.2	12.7	3.6	-3.6	-3.0	-3.3	-3.3	3.2	3.1	3.1	2.5	2.8	1.3
Bone: cortical thickness	2.1	2.5	3.4	1.5	-1.5	-0.9	-1.8	-1.8	1.8	1.8	1.8	1.6	1.8	-0.2
Bone: cortical tissue density	0.2	0.3	0.9	0.1	-0.1	-0.7	0.3	0.3	-0.4	-0.4	-0.5	-0.7	-0.6	0.9
Condit. Reinf. active minus inactive responses	0.6	0.6	0.9	0.9	-0.9	-0.3	-0.9	-0.9	0.9	0.9	0.9	1.0	0.8	-0.2
Condit. Reinf. active-inactive response ratio	4.4	4.7	5.8	2.2	-2.2	-1.1	-2.4	-2.4	2.4	2.4	2.4	2.4	2.3	-0.3
Condit. Reinf. active responses	0.1	0.2	0.2	-0.4	0.4	0.5	0.5	0.5	-0.4	-0.4	-0.4	-0.2	-0.4	-0.2
Condit. Reinf. inactive responses	5.1	6.6	8.3	-2.5	2.5	1.2	2.9	2.9	-2.9	-2.9	-2.9	-2.9	-2.8	0.4
Incentive salience index mean	0.5	0.7	1.3	0.7	-0.7	-0.0	-0.9	-0.9	0.9	0.9	0.9	1.1	1.0	-0.5
Condit. Reinf. lever presses	0.4	0.6	2.0	-0.1	0.1	1.0	-0.4	-0.5	0.6	0.6	0.7	1.1	0.9	-1.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	-0.7	0.8	0.7	0.7	0.7	-0.7	-0.7	-0.6	-0.4	-0.6	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	0.5	-0.5	-0.0	-0.6	-0.6	0.6	0.6	0.6	0.8	0.7	-0.3
Condit. Reinf. active responses	1.4	2.0	2.6	-1.3	1.4	1.0	1.6	1.6	-1.6	-1.6	-1.6	-1.3	-1.5	-0.1
Condit. Reinf. inactive responses	4.1	6.1	8.1	-2.3	2.3	1.1	2.8	2.8	-2.8	-2.8	-2.8	-2.7	-2.8	0.4
Condit. Reinf. lever presses	0.6	0.8	1.5	-0.1	0.2	-0.6	0.8	0.9	-1.0	-1.0	-1.0	-1.1	-1.2	1.2
Condit. Reinf. lever reinforcers received	1.4	2.0	2.8	-1.3	1.4	0.9	1.6	1.6	-1.6	-1.7	-1.6	-1.4	-1.6	0.1
Conditioned reinforcement - actives	0.6	2.4	3.2	-1.7	1.8	1.3	1.7	1.7	-1.7	-1.7	-1.6	-1.5	-1.5	-0.5
Conditioned reinforcement - inactives	0.1	0.4	0.5	-0.6	0.7	0.6	0.7	0.7	-0.6	-0.6	-0.6	-0.5	-0.6	-0.1
Conditioned locomotion	0.1	0.1	0.5	0.3	-0.3	-0.7	0.1	0.1	-0.2	-0.2	-0.2	-0.4	-0.4	0.7
Patch foraging indifference point 0 sec	0.1	0.4	0.5	-0.7	0.7	0.5	0.7	0.7	-0.6	-0.6	-0.6	-0.6	-0.6	-0.3
Patch foraging indifference point AUC	0.1	0.3	1.0	0.1	-0.1	-0.6	0.4	0.4	-0.5	-0.5	-0.5	-0.7	-0.7	1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.0	0.4	0.4	0.3	0.3	-0.3	-0.3	-0.3	-0.2	-0.3	-0.3
Delay disc. indifference point, 16s delay	0.6	0.8	1.6	1.2	-1.1	-1.3	-0.9	-0.9	0.8	0.8	0.8	0.6	0.6	0.4
Delay disc. indifference point, 2s delay	0.5	0.6	1.1	1.1	-0.8	-1.0	-0.9	-0.8	0.8	0.8	0.8	0.6	0.6	-0.1
Delay disc. indifference point, 24s delay	0.1	0.2	0.4	0.5	-0.5	-0.6	-0.4	-0.4	0.3	0.3	0.3	0.3	0.2	0.4
Delay disc. indifference point, 4s delay	1.1	1.2	1.9	1.4	-1.1	-0.7	-1.2	-1.2	1.2	1.1	1.2	1.1	1.0	0.4
Delay disc. indifference point, 8s delay	0.5	0.8	1.1	1.1	-1.0	-0.9	-1.0	-0.9	0.9	0.9	0.9	0.8	0.8	-0.0
Indifference point function ln k	0.2	0.6	1.3	-1.0	1.0	1.1	0.7	0.7	-0.6	-0.6	-0.6	-0.4	-0.4	-1.0
Indifference point function log k	0.2	0.6	1.3	-1.0	1.0	1.1	0.7	0.7	-0.6	-0.6	-0.6	-0.4	-0.4	-1.0
Patch foraging total patch changes 0 sec	0.2	0.5	0.7	-0.8	0.8	0.5	0.8	0.8	-0.8	-0.8	-0.8	-0.7	-0.7	-0.3
Patch foraging total patch changes 12 sec	0.3	0.5	0.7	0.8	-0.8	-0.6	-0.7	-0.7	0.7	0.7	0.7	0.7	0.6	0.3
Patch foraging total patch changes 18 sec	0.4	0.8	1.3	1.1	-1.1	-0.6	-1.0	-1.0	1.0	1.0	1.0	1.0	0.9	0.1
Patch foraging total patch changes 24 sec	0.1	0.3	0.8	0.8	-0.7	-0.9	-0.6	-0.5	0.5	0.5	0.4	0.3	0.3	0.7
Patch foraging total patch changes 6 sec	0.2	0.4	0.8	-0.2	0.2	-0.5	0.6	0.6	-0.7	-0.7	-0.7	-0.9	-0.8	0.8
Patch foraging time to switch 0 sec	0.8	3.2	4.7	1.6	-1.7	-0.6	-2.0	-2.0	2.0	2.0	2.1	2.2	2.1	-0.5
Patch foraging water rate 0 sec	0.4	1.7	2.9	-1.0	1.0	0.0	1.4	1.4	-1.5	-1.5	-1.5	-1.7	-1.6	0.8
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.2	0.1	0.2	0.0	0.0	-0.0	-0.0	-0.0	-0.0	0.0	-0.3
Patch foraging water rate 18 sec	1.6	3.6	5.2	-2.2	2.3	1.8	2.1	2.1	-2.0	-2.0	-1.9	-1.7	-1.7	-0.8
Patch foraging water rate 24 sec	0.4	0.6	0.9	-0.7	0.7	0.2	0.9	0.9	-0.9	-0.9	-0.9	-1.0	-0.9	0.3
Patch foraging water rate 6 sec	0.1	0.2	0.8	0.2	-0.3	-0.7	0.1	0.1	-0.2	-0.3	-0.3	-0.5	-0.4	0.9
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.8	0.7	-0.7	-1.3	-0.1	-0.1	-0.0	-0.1	-0.1	-0.4	-0.3	1.2
Distance traveled before self-admin	1.0	2.1	5.7	2.0	-2.0	-2.4	-1.4	-1.4	1.2	1.2	1.1	0.6	0.8	0.7
Distance traveled after self-admin	0.2	0.4	0.8	0.9	-0.8	-0.8	-0.6	-0.6	0.6	0.5	0.5	0.4	0.4	0.3
Extensor digitorum longus weight	5.2	20.7	28.5	-5.3	5.3	4.2	5.0	5.0	-4.8	-4.7	-4.7	-4.0	-4.2	-1.8
Bone: elastic displacement	0.2	0.2	0.8	0.5	-0.5	-0.9	-0.1	-0.1	0.0	-0.0	-0.0	-0.3	-0.2	0.8
Bone: elastic work	3.8	5.0	7.5	2.7	-2.7	-2.5	-2.4	-2.4	2.3	2.2	2.2	1.7	1.9	1.2
Bone: endosteal estimation	0.2	0.6	0.8	-0.8	0.8	0.5	0.9	0.9	-0.9	-0.9	-0.9	-0.8	-0.9	0.1
Bone: endosteal perimeter	1.3	3.1	4.0	-1.7	1.7	0.9	2.0	2.0	-2.0	-2.0	-2.0	-1.9	-1.9	0.3
Epididymis fat weight	2.7	13.4	35.5	-4.8	4.9	6.0	3.2	3.1	-2.6	-2.6	-2.4	-1.0	-1.5	-4.8
Delta time in closed arm before/after self-admin	0.6	0.5	2.9	0.4	-0.4	-1.1	0.2	0.2	-0.3	-0.4	-0.4	-0.7	-0.6	1.7
Delta time in open arm before/after self-admin	0.6	0.7	4.0	-0.8	0.8	1.3	0.4	0.4	-0.2	-0.2	-0.2	0.1	0.0	-2.0
Diff in mean of infusions in LGA sessions	0.3	0.5	2.0	-0.8	0.8	1.4	0.3	0.3	-0.2	-0.1	-0.1	0.3	0.1	-1.3
Delay discount exponential model param	0.7	1.0	1.8	-1.3	1.1	1.2	1.1	1.1	-1.0	-1.0	-0.9	-0.8	-0.8	-0.4
Extinction: sum of active levers before priming	1.8	2.7	3.5	-1.9	1.9	1.6	1.8	1.8	-1.7	-1.7	-1.7	-1.4	-1.5	-0.6
Active lever presses in extinction session 6	1.9	1.9	2.8	-1.7	1.7	1.6	1.5	1.4	-1.3	-1.3	-1.3	-1.0	-1.1	-0.9
Bone: final force	1.6	2.7	3.6	1.5	-1.5	-0.6	-1.8	-1.8	1.9	1.9	1.9	1.9	1.9	-0.4
Bone: final moment	1.2	2.0	2.6	1.3	-1.3	-0.6	-1.6	-1.6	1.6	1.6	1.6	1.6	1.6	-0.3
Food consumed during 24 hour testing period	0.1	0.2	0.5	-0.5	0.5	0.7	0.4	0.4	-0.3	-0.3	-0.3	-0.1	-0.2	-0.5
Glucose	2.4	3.8	7.4	2.5	-2.6	-2.7	-1.9	-1.9	1.7	1.6	1.6	1.0	1.2	1.9
Heart weight	0.5	0.8	3.6	-1.1	1.1	1.7	0.3	0.3	-0.1	-0.0	-0.0	0.4	0.3	-1.9
Delay discount hyperbolic model param	1.0	1.3	2.2	-1.5	1.3	1.2	1.2	1.2	-1.1	-1.1	-1.1	-1.0	-0.9	-0.4
Intermittent access intake day 1-15 change	0.2	0.9	2.4	-0.1	0.2	-0.8	0.7	0.8	-0.9	-0.9	-0.9	-1.3	-1.1	1.6
Intermittent access intake escalation	0.2	1.0	2.6	-0.2	0.2	-0.8	0.8	0.9	-1.0	-1.0	-1.0	-1.4	-1.2	1.6
Intermittent access intake escalation 2	0.5	0.8	2.9	0.0	-0.0	-1.0	0.6	0.6	-0.8	-0.8	-0.8	-1.2	-1.0	1.7
Intermitt. access day 1 inactive lever presses	0.1	1.1	5.0	1.2	-1.1	-1.9	-0.3	-0.3	0.1	0.0	-0.0	-0.5	-0.3	2.2
Intermitt. access day 15 inactive lever presses	0.2	1.0	4.2	0.8	-0.8	-1.9	0.1	0.2	-0.4	-0.4	-0.5	-1.0	-0.8	2.0
Intermitt. access escalation Index	0.4	1.4	2.8	0.3	-0.4	0.8	-1.0	-1.1	1.2	1.2	1.3	1.6	1.5	-1.7
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.0	-0.1	-0.1	0.0	0.0	-0.0	-0.1	-0.0	-0.1	-0.1	0.1
Intermittent access day 15 total infusions	0.5	1.1	2.1	-0.7	0.7	-0.0	1.1	1.1	-1.2	-1.2	-1.2	-1.4	-1.3	0.8
Intermittent access terminal intake (last 3 days)	0.7	1.3	1.9	-1.2	1.1	0.6	1.3	1.3	-1.3	-1.3	-1.3	-1.4	-1.2	0.1
Intermittent access total infusions	0.4	0.5	1.0	-0.5	0.4	-0.1	0.7	0.7	-0.8	-0.8	-0.8	-1.0	-0.9	0.5
Intermittent access day 1 locomotion	0.2	0.4	0.6	0.7	-0.8	-0.5	-0.7	-0.7	0.6	0.6	0.6	0.6	0.5	0.2
Intermittent access day 15 total locomotion	0.0	0.1	0.7	0.3	-0.3	-0.7	0.0	0.0	-0.1	-0.1	-0.1	-0.3	-0.3	0.8
Intermittent access total locomotion	0.1	0.1	0.3	0.1	-0.0	-0.3	0.2	0.2	-0.3	-0.3	-0.3	-0.4	-0.4	0.6
Intermittent access standard deviation	0.6	2.9	5.6	-0.8	0.9	-0.6	1.7	1.7	-1.9	-1.9	-1.9	-2.4	-2.1	1.9
Left kidney weight	1.5	11.8	14.8	3.5	-3.5	-1.9	-3.8	-3.8	3.8	3.8	3.8	3.8	3.7	-0.4
Right kidney weight	1.6	11.4	15.4	3.1	-3.1	-1.3	-3.8	-3.8	3.8	3.8	3.8	3.9	3.8	-1.0
Cocaine induced anxiety	0.0	0.1	0.4	0.1	-0.1	-0.4	0.2	0.2	-0.2	-0.2	-0.2	-0.3	-0.3	0.6
Post-drug Anxiety	0.2	0.2	1.0	-0.2	0.3	0.8	-0.1	-0.2	0.3	0.3	0.3	0.5	0.5	-1.0
Baseline Anxiety	0.3	0.5	2.4	-0.6	0.7	1.3	0.0	0.0	0.1	0.2	0.2	0.5	0.5	-1.6
Tail length	1.0	5.5	10.9	0.6	-0.6	1.9	-2.0	-2.1	2.4	2.4	2.5	3.3	2.9	-3.3
Length with tail	1.8	8.0	15.6	1.1	-1.1	1.6	-2.6	-2.7	3.0	3.1	3.1	3.9	3.6	-3.4
Length without tail	0.3	1.4	4.5	-0.1	0.1	1.4	-0.8	-0.9	1.0	1.1	1.1	1.6	1.4	-2.1
Times rat made contact with spout	2.2	2.5	3.2	1.6	-1.6	-0.8	-1.8	-1.8	1.8	1.8	1.8	1.8	1.7	-0.1
Lifetime Intake	0.3	0.4	0.8	-0.4	0.3	-0.1	0.6	0.7	-0.7	-0.7	-0.7	-0.9	-0.8	0.4
Liver weight, left	2.7	4.6	16.5	-0.3	0.4	2.8	-1.2	-1.3	1.7	1.8	1.8	2.8	2.4	-4.1
Liver weight, right	1.6	2.9	11.5	-0.6	0.7	2.6	-0.7	-0.8	1.1	1.1	1.2	2.1	1.7	-3.4
Locomotor activity	0.0	0.1	0.1	-0.2	0.3	0.4	0.2	0.2	-0.1	-0.1	-0.1	-0.0	-0.1	-0.4
Locomotor testing distance	0.0	0.0	0.1	-0.2	0.3	0.3	0.2	0.2	-0.2	-0.2	-0.2	-0.1	-0.1	-0.3
Locomotor testing rearing	0.3	1.2	1.5	-1.0	1.1	0.5	1.2	1.2	-1.2	-1.2	-1.2	-1.2	-1.2	0.1
Locomotion in novel chamber	1.2	1.6	3.4	0.2	-0.2	-1.8	0.9	0.9	-1.2	-1.2	-1.3	-1.8	-1.6	1.5
Locomotion in novel chamber post-restriction	0.3	0.9	1.2	-0.8	0.8	0.3	1.0	1.0	-1.1	-1.1	-1.1	-1.1	-1.1	-0.3
Fecal boli incidents, locomotor time 1	0.0	0.1	0.8	-0.2	0.0	0.1	-0.2	-0.2	0.2	0.2	0.2	0.3	0.3	-0.9
Change in fecal boli incidents, locomotor task	0.7	0.8	1.1	1.0	-0.9	-0.5	-1.0	-1.0	1.0	1.0	1.0	0.9	0.9	0.4
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	-0.4	0.6	0.4	0.5	0.5	-0.5	-0.5	-0.5	-0.4	-0.4	-0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.5	-0.1	0.1	0.2	0.2	0.1	-0.1	-0.2	-0.1	0.0	-0.1	-0.7
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.2	0.2	0.1	0.3	0.3	-0.3	-0.3	-0.3	-0.2	-0.3	-0.4
Rest time, locomotor task time 1	0.1	0.2	1.2	0.3	-0.3	-0.7	0.0	0.0	-0.1	-0.1	-0.1	-0.2	-0.3	1.1
Distance moved, locomotor task time 1	0.0	0.1	0.1	-0.3	0.3	0.3	0.3	0.3	-0.3	-0.3	-0.3	-0.2	-0.2	-0.4
Vertical activity count, locomotor time 1	0.1	0.8	1.2	-1.0	1.1	0.9	0.9	0.9	-0.9	-0.9	-0.9	-0.7	-0.8	-1.1
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.0	1.0	-0.8	-0.8	-0.8	-0.8	0.7	0.8	0.7	0.6	0.6	0.6
Bouts of movement, locomotor time 2	0.0	0.1	0.1	0.4	-0.4	-0.2	-0.4	-0.4	0.3	0.3	0.3	0.3	0.3	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.0	-0.0	0.0	0.0	0.0	0.1	0.0	0.1
Rest time, locomotor task time 2	0.1	0.2	0.4	-0.5	0.5	0.2	0.5	0.5	-0.5	-0.5	-0.5	-0.6	-0.4	0.3
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.3	-0.1	-0.5	0.2	0.2	-0.3	-0.4	-0.3	-0.3	-0.5	0.5
Vertical activity count, locomotor time 2	0.1	0.2	0.5	0.7	-0.6	-0.5	-0.5	-0.5	0.5	0.4	0.5	0.5	0.4	-0.0
Light reinforcement 1	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	0.2	-0.2	-0.2	-0.2	-0.1	-0.2	-0.0
Light reinforcement 2	1.4	3.1	4.2	2.0	-2.0	-1.5	-2.0	-2.0	1.9	1.9	1.8	1.6	1.7	0.6
Bone: marrow area	0.2	0.5	0.7	-0.7	0.7	0.5	0.8	0.8	-0.8	-0.8	-0.8	-0.7	-0.8	0.1
Bone: maximum diameter	0.3	0.5	0.9	-0.4	0.3	-0.2	0.7	0.7	-0.8	-0.8	-0.8	-1.0	-0.9	0.9
Bone: maximum force	1.4	2.7	3.4	1.6	-1.6	-0.9	-1.8	-1.9	1.8	1.9	1.8	1.8	1.8	-0.1
Bone: maximum moment	1.0	1.9	2.5	1.4	-1.4	-0.9	-1.6	-1.6	1.5	1.5	1.5	1.4	1.5	0.1
Mean time between licks in bursts	0.1	0.4	0.8	0.0	-0.0	0.6	-0.5	-0.6	0.7	0.7	0.7	0.9	0.9	-0.9
Mean num. licks in bursts	0.2	0.7	1.6	0.4	-0.4	0.3	-0.8	-0.8	0.9	0.9	0.9	1.0	0.9	-1.3
Cd content in liver	1.7	1.9	2.5	-1.3	1.3	0.4	1.5	1.5	-1.5	-1.5	-1.5	-1.6	-1.5	1.1
Co content in liver	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.3	0.3	0.3	0.2	0.3	0.2
Cu content in liver	0.6	0.7	1.2	1.1	-1.1	-1.0	-0.9	-0.9	0.8	0.8	0.8	0.6	0.6	0.8
Fe content in liver	0.4	0.5	1.0	0.2	-0.2	0.6	-0.6	-0.6	0.7	0.7	0.8	1.0	0.9	-0.6
K content in liver	1.2	1.2	2.2	0.7	-0.7	0.2	-1.1	-1.2	1.2	1.3	1.3	1.5	1.4	-0.7
Mg content in liver	0.2	0.2	0.3	-0.4	0.4	0.2	0.5	0.5	-0.5	-0.5	-0.5	-0.5	-0.5	0.2
Mn content in liver	1.0	1.1	1.4	-1.0	1.0	0.5	1.2	1.2	-1.2	-1.2	-1.2	-1.2	-1.1	0.3
Na content in liver	2.7	3.1	4.3	2.1	-2.1	-1.5	-1.9	-1.9	1.8	1.8	1.8	1.7	1.6	-0.3
Rb content in liver	3.9	4.5	6.0	-2.5	2.5	1.8	2.4	2.3	-2.3	-2.2	-2.2	-2.0	-2.0	-0.3
Se content in liver	0.5	0.6	1.5	0.9	-0.9	-0.7	-0.8	-0.8	0.7	0.7	0.7	0.6	0.6	1.2
Sr content in liver	1.8	1.6	2.0	-1.3	1.3	0.9	1.4	1.4	-1.4	-1.4	-1.4	-1.3	-1.3	-0.3
Zn content in liver	0.1	0.1	0.4	-0.1	0.1	0.6	-0.2	-0.2	0.3	0.3	0.3	0.5	0.5	-0.4
Bone: minimum diameter	0.9	1.8	2.3	1.4	-1.4	-1.0	-1.5	-1.5	1.5	1.5	1.5	1.3	1.4	0.2
Time in familiar zone, hab. session 1	2.4	2.6	4.0	-1.6	1.6	0.5	1.8	1.8	-1.8	-1.8	-1.8	-2.0	-1.8	0.5
Time in novel zone, hab. session 1	2.1	2.4	3.6	1.5	-1.6	-0.5	-1.7	-1.7	1.7	1.7	1.7	1.9	1.7	-0.4
Total zone transitions, hab. session 1	3.0	4.2	5.3	-2.0	2.0	1.0	2.3	2.3	-2.3	-2.3	-2.3	-2.2	-2.2	0.3
Total locomotion distance, hab. session 1	0.8	1.1	1.4	-1.2	1.2	0.8	1.2	1.2	-1.2	-1.2	-1.2	-1.1	-1.1	-0.1
Locomotion velocity, hab. session 1	1.0	1.5	1.8	-1.3	1.3	0.7	1.3	1.3	-1.3	-1.3	-1.3	-1.3	-1.3	0.0
Time in familiar zone, hab. session 2	2.2	2.5	3.1	-1.8	1.8	1.2	1.7	1.7	-1.7	-1.7	-1.7	-1.6	-1.5	-0.3
Time in novel zone, hab. session 2	4.9	5.4	7.1	2.6	-2.7	-1.8	-2.6	-2.6	2.5	2.5	2.5	2.2	2.3	0.6
Total zone transitions, hab. session 2	0.9	1.1	1.7	-1.3	1.3	1.2	1.2	1.1	-1.1	-1.1	-1.0	-0.8	-0.9	-0.6
Total locomotion distance, hab. session 2	0.0	0.1	0.2	-0.4	0.3	0.4	0.2	0.2	-0.1	-0.1	-0.1	-0.1	-0.0	-0.4
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.3	0.3	0.3	0.1	0.1	-0.1	-0.1	-0.1	-0.0	-0.0	-0.3
Novel to familiar place preference ratio	0.2	0.2	0.6	-0.1	0.1	-0.5	0.3	0.3	-0.4	-0.4	-0.4	-0.7	-0.5	0.8
Novelty place preference	0.0	0.0	0.1	-0.0	0.0	-0.3	0.1	0.1	-0.1	-0.1	-0.2	-0.3	-0.2	0.4
Time in novel zone, NPP test	0.1	0.1	0.1	-0.3	0.3	-0.0	0.3	0.3	-0.3	-0.2	-0.3	-0.4	-0.3	0.1
Total zone transitions, NPP test	1.7	2.5	3.1	-1.7	1.7	1.0	1.8	1.8	-1.7	-1.7	-1.7	-1.7	-1.6	-0.1
Total locomotion distance, NPP test	0.7	1.0	1.6	-0.9	0.9	0.1	1.1	1.1	-1.2	-1.2	-1.2	-1.3	-1.2	0.5
Locomotion velocity, NPP test	0.6	0.9	1.7	-0.5	0.5	-0.4	0.9	1.0	-1.0	-1.0	-1.1	-1.3	-1.2	1.0
Intraocular pressure	1.3	2.1	3.7	-0.7	0.7	-0.6	1.4	1.5	-1.6	-1.6	-1.6	-1.9	-1.8	1.7
Delta distance traveled before/after self-admin	0.8	0.9	3.2	-1.3	1.3	1.8	0.8	0.8	-0.7	-0.7	-0.6	-0.2	-0.4	-0.8
Delta ambulatory time before/after self-admin	0.6	1.0	2.9	-1.3	1.3	1.7	0.9	0.9	-0.7	-0.7	-0.7	-0.3	-0.5	-1.0
Parametrial fat weight	3.6	8.4	25.2	-3.8	3.8	5.0	2.3	2.2	-1.8	-1.7	-1.6	-0.3	-0.8	-4.4
Pavlov. Cond. lever latency	0.8	1.0	1.7	-0.8	0.8	0.1	1.1	1.1	-1.1	-1.1	-1.1	-1.3	-1.2	0.6
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	0.1	-0.1	0.6	-0.5	-0.6	0.7	0.7	0.7	1.0	0.8	-1.0
Pavlov. Cond. change in total contacts	0.8	0.9	1.4	1.2	-1.2	-0.8	-1.0	-1.0	1.0	0.9	1.0	1.0	0.8	0.3
Pavlov. Cond. index score	0.6	0.7	1.6	0.3	-0.3	0.6	-0.8	-0.8	0.9	0.9	0.9	1.3	1.1	-1.1
Pavlov. Cond. latency score	1.0	1.3	2.7	0.5	-0.5	0.6	-1.1	-1.1	1.2	1.2	1.3	1.6	1.4	-1.3
Pavlov. Cond. lever contacts	0.7	0.8	1.5	0.7	-0.7	-0.0	-1.0	-1.0	1.0	1.1	1.1	1.2	1.1	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.0	-0.0	-0.4	0.1	0.2	-0.2	-0.2	-0.2	-0.4	-0.3	0.5
Pavlov. Cond. intertrial magazine entries	1.3	1.6	2.5	-0.9	0.9	0.0	1.3	1.4	-1.4	-1.4	-1.4	-1.6	-1.5	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	0.2	-0.2	0.5	-0.6	-0.6	0.7	0.7	0.8	1.0	0.9	-1.0
Pavlov. Cond. response bias	0.2	0.3	0.7	0.0	-0.0	0.6	-0.3	-0.4	0.4	0.5	0.5	0.7	0.6	-0.8
Pavlov. Cond. lever latency	0.6	0.8	2.2	-1.3	1.2	1.5	0.7	0.7	-0.6	-0.6	-0.5	-0.3	-0.3	-1.2
Pavlov. Cond. magazine entry latency	1.4	2.0	2.5	1.5	-1.5	-1.1	-1.6	-1.6	1.5	1.5	1.5	1.4	1.4	0.4
Pavlov. Cond. change in total contacts	0.4	1.0	1.6	1.3	-1.2	-1.2	-1.0	-1.0	0.9	0.9	0.9	0.7	0.7	0.9
Pavlov. Cond. index score	0.8	1.3	3.0	1.5	-1.5	-1.7	-1.1	-1.0	0.9	0.9	0.8	0.5	0.6	1.4
Pavlov. Cond. latency score	0.9	1.4	3.5	1.6	-1.6	-1.9	-1.0	-1.0	0.9	0.8	0.8	0.4	0.5	1.6
Pavlov. Cond. lever contacts	0.4	0.7	1.2	1.1	-1.0	-1.0	-0.8	-0.8	0.7	0.7	0.7	0.5	0.5	0.7
Pavlov. Cond. magazine entry number	1.4	1.9	2.4	-1.5	1.5	1.3	1.5	1.5	-1.4	-1.4	-1.4	-1.2	-1.3	-0.6
Pavlov. Cond. intertrial magazine entries	1.4	3.0	3.8	-2.0	2.0	1.7	1.9	1.9	-1.8	-1.8	-1.8	-1.4	-1.6	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.2	2.8	1.5	-1.4	-1.7	-1.0	-1.0	0.8	0.8	0.8	0.5	0.5	1.4
Pavlov. Cond. response bias	1.0	1.4	2.2	1.5	-1.4	-1.3	-1.3	-1.2	1.2	1.1	1.1	0.9	0.9	0.8
Time in closed arm before self-admin	0.5	0.9	4.7	-0.9	1.0	1.7	0.3	0.2	-0.1	-0.0	0.0	0.5	0.3	-2.2
Time in closed arm after self-admin	0.3	0.4	0.7	0.8	-0.8	-0.7	-0.7	-0.7	0.6	0.6	0.6	0.5	0.5	-0.1
Time in open arm before self-admin	2.1	2.5	5.7	2.0	-2.0	-2.3	-1.4	-1.3	1.2	1.1	1.1	0.6	0.7	2.4
Time in open arm after self-admin	0.2	0.2	0.8	0.6	-0.6	-0.9	-0.3	-0.3	0.2	0.2	0.2	-0.1	0.0	0.4
Bone: periosteal estimation	0.2	0.4	0.6	0.8	-0.8	-0.6	-0.7	-0.7	0.7	0.6	0.6	0.5	0.5	0.4
Bone: periosteal perimeter	0.0	0.1	0.4	0.1	-0.1	-0.4	0.1	0.1	-0.2	-0.2	-0.2	-0.4	-0.3	0.6
Bone: post-yield work	0.1	0.2	0.8	-0.5	0.5	0.9	0.1	0.0	0.0	0.1	0.1	0.4	0.3	-0.9
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	-0.1	-0.1	-0.4	0.2	0.3	-0.3	-0.3	-0.3	-0.6	-0.5	0.6
Progressive ratio test 1 breakpoint	0.1	0.2	0.5	-0.1	-0.1	-0.4	0.3	0.4	-0.4	-0.4	-0.4	-0.7	-0.6	0.6
Progressive ratio test 1 inactive lever presses	0.3	0.8	3.2	1.1	-1.2	-1.7	-0.5	-0.4	0.3	0.2	0.2	-0.2	-0.1	1.8
Progressive ratio test 2 active lever presses	1.2	1.7	3.0	-1.1	0.9	0.2	1.4	1.4	-1.5	-1.5	-1.5	-1.7	-1.6	0.7
Progressive ratio test 2 breakpoint	1.4	1.7	3.0	-1.1	1.0	0.2	1.4	1.5	-1.5	-1.5	-1.5	-1.7	-1.6	0.6
Progressive ratio test 2 inactive lever presses	0.3	0.8	1.7	-0.2	0.2	-0.7	0.8	0.8	-0.9	-0.9	-0.9	-1.3	-1.1	1.3
Incentive Sensitization - Responses	0.7	2.0	2.7	-1.3	1.3	0.5	1.6	1.6	-1.6	-1.6	-1.6	-1.6	-1.6	0.4
Incentive Sensitization - Breakpoint	0.8	1.8	2.3	-1.2	1.2	0.5	1.5	1.5	-1.5	-1.5	-1.5	-1.5	-1.5	0.4
Sum of active levers in priming session hrs 5-6	1.2	1.1	5.4	-1.1	1.1	1.8	0.5	0.4	-0.2	-0.2	-0.2	0.3	0.1	-2.3
Progressive ratio	0.1	0.4	0.8	-0.3	0.3	-0.4	0.6	0.6	-0.7	-0.7	-0.7	-0.9	-0.8	0.1
Food seeking constrained by brief footshock	0.0	0.0	0.3	0.1	-0.1	-0.2	0.0	0.1	-0.1	-0.1	-0.1	-0.2	-0.1	0.5
Seeking ratio, punishment vs. effort	0.6	1.3	1.6	1.1	-1.1	-0.6	-1.3	-1.3	1.3	1.3	1.3	1.2	1.2	0.3
Retroperitoneal fat weight	0.1	0.3	1.1	-0.7	0.8	1.1	0.5	0.4	-0.3	-0.3	-0.3	0.1	-0.1	-0.9
Reaction time number correct	0.0	0.0	0.2	-0.2	0.2	0.4	0.2	0.1	-0.1	-0.1	-0.1	0.1	-0.0	-0.4
Reaction time mean minus median	0.1	0.4	0.8	-0.2	0.2	-0.3	0.6	0.6	-0.7	-0.7	-0.7	-0.8	-0.8	0.9
Reaction time mean minus median AUC	0.3	2.3	3.0	-1.4	1.4	0.6	1.7	1.7	-1.7	-1.7	-1.7	-1.7	-1.7	0.5
Reaction time num false alarms	1.2	2.0	3.5	-0.9	0.9	-0.3	1.5	1.5	-1.6	-1.6	-1.6	-1.9	-1.8	1.2
Reaction time num false alarms AUC	0.8	1.8	3.2	-0.8	0.8	-0.3	1.4	1.4	-1.5	-1.5	-1.5	-1.8	-1.7	1.2
Reaction time trials correct on left	0.0	0.0	0.2	-0.2	0.2	0.4	0.2	0.1	-0.1	-0.1	-0.1	0.1	-0.0	-0.4
Reaction time trials on left	0.0	0.1	0.2	-0.2	0.2	0.4	0.2	0.2	-0.2	-0.2	-0.1	0.0	-0.1	-0.4
Reaction time mean	0.0	0.0	0.2	0.2	-0.2	-0.3	-0.1	-0.1	0.0	0.0	0.0	-0.1	-0.0	0.4
Reaction time mean AUC	0.1	0.1	0.8	0.3	-0.3	-0.6	-0.0	0.0	-0.1	-0.1	-0.1	-0.3	-0.2	0.9
Median of all reaction times	0.1	0.1	0.2	0.4	-0.5	-0.4	-0.4	-0.4	0.4	0.4	0.4	0.3	0.3	0.3
Reaction time omissions	0.0	0.0	0.1	-0.2	0.3	0.3	0.2	0.2	-0.2	-0.2	-0.2	-0.0	-0.2	-0.1
Reaction time false alarm rate	1.0	1.4	2.6	-0.7	0.7	-0.3	1.2	1.2	-1.3	-1.3	-1.4	-1.6	-1.5	1.1
Reaction time premature initiation rate	0.5	0.8	1.0	-0.9	1.0	0.8	1.0	1.0	-0.9	-0.9	-0.9	-0.8	-0.8	-0.2
Reaction time premature initiations	0.3	1.0	1.3	-1.1	1.1	0.9	1.1	1.1	-1.1	-1.1	-1.1	-0.9	-1.0	-0.3
Std. dev. reaction times	0.1	0.5	0.8	-0.3	0.3	-0.2	0.6	0.7	-0.7	-0.7	-0.7	-0.9	-0.8	0.9
Reaction time trials completed	0.0	0.1	0.2	-0.2	0.2	0.4	0.2	0.2	-0.2	-0.2	-0.1	0.0	-0.1	-0.4
Reaction time trials AUC	0.0	0.0	0.2	-0.2	0.2	0.4	0.2	0.2	-0.2	-0.2	-0.2	-0.0	-0.1	-0.3
Run reversals in cocaine runway, females	1.0	1.1	4.6	-0.4	0.5	-0.4	0.9	0.9	-1.0	-1.0	-1.0	-1.2	-1.1	2.2
Run reversals in cocaine runway, males	1.2	1.3	2.0	-1.0	1.0	0.3	1.3	1.3	-1.3	-1.3	-1.3	-1.4	-1.3	0.6
Latency to leave start box in cocaine runway	0.2	0.2	0.3	0.4	-0.5	-0.3	-0.5	-0.5	0.5	0.5	0.5	0.5	0.5	0.6
Latency to leave start box in cocaine runway, F	0.3	0.4	0.7	0.4	-0.5	0.1	-0.7	-0.7	0.8	0.8	0.8	0.8	0.9	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	-0.2	-0.3	0.0	0.1	-0.1	-0.1	-0.1	-0.1	-0.2	0.4
Std. dev. time between licks in bursts	0.2	0.4	0.5	-0.7	0.7	0.5	0.7	0.7	-0.6	-0.6	-0.6	-0.6	-0.6	-0.7
Total sessions with >9 infusions	0.4	0.5	1.0	-0.4	0.3	-0.1	0.7	0.7	-0.8	-0.8	-0.8	-1.0	-0.9	0.5
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.3	0.3	0.3	0.2	0.2	-0.2	-0.2	-0.2	-0.2	-0.1	-0.0
Short access day 10 total inactive lever presses	0.1	0.5	1.2	0.9	-0.9	-1.1	-0.6	-0.5	0.4	0.5	0.4	0.1	0.3	1.1
Short access day 1 total infusions	0.2	0.5	1.4	0.1	-0.3	-0.9	0.4	0.4	-0.5	-0.6	-0.6	-1.0	-0.8	1.2
Short access day 10 total infusions	0.3	0.5	1.1	-0.2	0.1	-0.4	0.7	0.7	-0.8	-0.8	-0.8	-1.0	-1.0	0.9
Short access total infusions	0.2	0.3	1.0	0.1	-0.3	-0.8	0.3	0.3	-0.4	-0.5	-0.5	-0.8	-0.7	1.0
Short access day 1 locomotion	0.4	0.6	2.2	1.0	-1.0	-1.5	-0.4	-0.4	0.2	0.2	0.2	-0.3	-0.1	1.4
Short access day 10 total locomotion	0.1	0.4	1.8	0.8	-0.8	-1.2	-0.3	-0.2	0.1	0.1	0.1	-0.2	-0.2	1.3
Short access total locomotion	0.5	0.8	3.2	1.1	-1.1	-1.7	-0.3	-0.3	0.1	0.0	0.0	-0.4	-0.3	1.8
One hour access (0.3 mA shock)	1.4	1.6	2.1	-1.3	1.1	0.7	1.4	1.4	-1.4	-1.4	-1.4	-1.5	-1.4	0.1
Compulsive drug intake	0.3	0.5	2.2	-0.3	0.2	1.0	-0.3	-0.3	0.4	0.4	0.5	0.8	0.7	-1.5
One hour access (shock baseline)	0.2	0.4	0.9	-0.3	0.3	-0.3	0.6	0.7	-0.7	-0.7	-0.7	-0.9	-0.8	0.8
Social response proportion	1.0	1.2	5.6	-0.6	0.6	1.8	-0.3	-0.4	0.6	0.6	0.7	1.2	1.0	-2.4
Social responses	0.6	0.8	3.6	-1.0	0.9	1.8	0.4	0.4	-0.2	-0.2	-0.2	0.4	0.1	-1.9
Social time	0.9	1.4	4.2	-1.5	1.4	2.1	0.9	0.9	-0.7	-0.7	-0.6	-0.1	-0.4	-1.8
Soleus weight	1.3	3.9	14.0	-2.6	2.5	3.7	1.2	1.1	-0.7	-0.7	-0.6	0.4	0.0	-3.5
Bone: stiffness	0.3	0.6	2.3	-0.5	0.4	1.3	-0.3	-0.3	0.5	0.5	0.5	0.9	0.8	-1.5
Tibialis anterior weight	7.4	25.3	39.0	-6.2	6.2	5.6	5.4	5.3	-5.0	-4.9	-4.8	-3.8	-4.1	-3.1
Time to tail flick, vehicle, before self-admin	3.9	4.8	8.2	-2.8	2.8	2.9	2.3	2.2	-2.0	-2.0	-1.9	-1.4	-1.6	-1.5
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.5	-0.7	0.7	0.7	0.6	0.6	-0.5	-0.5	-0.5	-0.4	-0.4	-0.7
Time to tail flick, test, before self-admin	0.3	0.3	1.2	-0.7	0.7	1.1	0.3	0.3	-0.2	-0.2	-0.2	0.1	0.0	-1.0
Time to tail flick, test, after self-admin	0.4	0.4	0.6	0.5	-0.6	-0.2	-0.7	-0.7	0.7	0.7	0.7	0.8	0.7	-0.4
Delta time to tail flick, vehicle, before/after SA	0.4	0.5	1.7	0.9	-0.9	-1.3	-0.5	-0.5	0.3	0.3	0.3	-0.0	0.1	1.0
Delta time to tail flick, test, before/after SA	0.1	0.2	0.8	0.3	-0.3	-0.8	0.1	0.1	-0.2	-0.2	-0.2	-0.4	-0.4	0.9
Tibia length	1.4	3.9	6.6	1.3	-1.3	0.1	-2.1	-2.1	2.3	2.3	2.3	2.6	2.5	-1.4
Ambulatory time before self-admin	1.3	3.9	6.3	2.5	-2.5	-2.5	-2.1	-2.1	1.9	1.9	1.9	1.4	1.6	0.4
Ambulatory time after self-admin	0.8	1.2	1.8	1.0	-1.0	-0.3	-1.2	-1.2	1.3	1.3	1.3	1.3	1.3	-0.7
Bone: tissue strength	2.0	2.1	3.3	1.8	-1.8	-1.4	-1.6	-1.6	1.5	1.5	1.4	1.3	1.3	0.7
Total heroin consumption	1.9	2.2	7.0	-2.1	2.0	2.6	1.3	1.2	-1.0	-1.0	-0.9	-0.3	-0.5	-1.6
Bone: trabecular number	3.1	5.8	9.9	-3.1	3.1	3.0	2.4	2.4	-2.2	-2.1	-2.1	-1.5	-1.7	-2.0
Bone: trabecular spacing	0.3	0.5	1.1	0.9	-1.0	-1.1	-0.6	-0.6	0.5	0.5	0.4	0.2	0.3	0.8
Bone: trabecular thickness	0.3	0.4	0.7	-0.8	0.8	0.9	0.6	0.6	-0.5	-0.5	-0.5	-0.3	-0.4	-0.6
Bone: trabecular tissue density	1.2	2.1	3.8	1.9	-1.9	-1.9	-1.5	-1.4	1.3	1.3	1.2	0.8	1.0	1.4
Water consumed over 24 hours	1.0	1.9	2.9	1.2	-1.2	-0.3	-1.5	-1.5	1.6	1.6	1.6	1.7	1.6	-0.1
Number of responses in last shaping day	0.5	0.6	2.7	0.8	-0.9	-1.5	-0.2	-0.2	0.0	-0.0	-0.0	-0.5	-0.3	1.6