Hub : Genes

Tesk1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Tesk1 0.06 0.04 9.1e-06 0.05 0.05 0.05 0.05 3.0e-06 5.3e-06 2.4e-06 2.0e-06
2 Brain mRNA stability Tesk1 0.08 0.05 3.2e-08 0.08 0.08 0.07 0.05 3.0e-08 2.9e-08 2.2e-07 1.3e-05
3 LHb gene expression Tesk1 0.39 0.19 2.3e-05 0.15 0.15 0.11 0.13 2.2e-04 2.4e-04 1.2e-03 4.9e-04
4 Brain gene expression Tesk1 0.3 0.11 0.0e+00 0.38 0.28 0.36 0.2 2.1e-37 1.5e-26 3.2e-35 4.3e-18
5 LHb mRNA stability Tesk1 0.14 0.09 1.9e-03 0.05 0.08 0.06 0.06 2.8e-02 6.0e-03 1.4e-02 1.9e-02
6 NAcc mRNA stability Tesk1 0.03 0.02 3.6e-05 0.03 0.02 0.03 0.01 8.4e-06 1.8e-04 1.6e-05 1.0e-02
7 pVTA gene expression Tesk1 0.22 0.09 0.0e+00 0.33 0.32 0.34 0.33 2.2e-27 1.7e-26 5.6e-28 7.7e-27
8 Eye gene expression Tesk1 0.34 0.2 3.6e-03 0.09 0.1 0.1 0.03 2.0e-02 1.3e-02 1.2e-02 1.2e-01
9 IL gene expression Tesk1 0.29 0.14 5.8e-07 0.24 0.22 0.23 0.28 1.7e-06 4.3e-06 2.7e-06 2.2e-07
10 NAcc gene expression Tesk1 0.18 0.09 0.0e+00 0.19 0.13 0.2 0.13 1.2e-27 6.0e-19 6.4e-29 9.9e-20
11 IC gene expression Tesk1 0.16 0.09 5.0e-07 0.12 0.13 0.13 0.12 1.4e-05 4.9e-06 6.2e-06 8.0e-06
12 PL gene expression Tesk1 0.23 0.09 0.0e+00 0.31 0.34 0.34 0.34 4.1e-34 6.6e-38 2.9e-38 7.1e-38
13 OFC gene expression Tesk1 0.27 0.13 1.1e-05 0.19 0.16 0.2 0.14 2.4e-05 1.0e-04 1.5e-05 3.6e-04
14 Liver gene expression Tesk1 0.02 0.02 5.4e-03 0.02 0.02 0.02 0.01 3.9e-03 4.2e-03 5.1e-03 8.2e-03
15 BLA gene expression Tesk1 0.57 0.18 0.0e+00 0.39 0.42 0.44 0.43 7.2e-22 4.8e-24 2.1e-25 1.2e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.73.23.61.51.7-1.7-1.91.8-1.7-1.8-1.91.8-1.81.9-1.8-1.9-1.9-1.7
Area under the delay curve0.71.02.8-0.8-0.91.11.0-0.91.11.00.8-1.11.0-1.01.00.80.81.7
BMI with tail1.96.58.52.32.7-2.6-2.42.7-2.5-2.6-2.92.2-2.52.6-2.3-2.2-2.9-2.7
BMI without tail1.37.18.32.72.9-2.9-2.82.8-2.7-2.7-2.82.4-2.62.6-2.4-2.2-2.7-2.6
Body weight2.611.316.04.03.9-3.5-3.53.8-3.3-3.4-3.72.8-3.03.0-2.7-2.5-3.4-3.3
Weight adjusted by age0.00.10.20.50.3-0.3-0.10.3-0.5-0.2-0.4-0.0-0.00.00.20.1-0.0-0.5
Bone surface0.81.61.91.31.4-1.2-1.41.4-1.2-1.3-1.41.1-1.21.2-1.1-1.1-1.4-1.3
Bone volume0.81.61.91.11.3-1.2-1.41.3-1.2-1.3-1.31.2-1.31.3-1.2-1.3-1.4-1.3
Breakpoint value in progressive ratio session2.03.76.3-0.7-1.31.92.0-1.41.71.91.4-2.52.3-2.32.52.51.61.7
Number of licking bursts2.16.47.52.52.6-2.7-2.62.6-2.5-2.6-2.52.5-2.52.5-2.4-2.3-2.3-2.7
Context. condit. distance diff. score0.00.00.2-0.4-0.30.30.2-0.20.20.30.3-0.20.2-0.10.10.10.0-0.1
Locomotion velocity, session 10.60.62.40.80.20.40.5-0.00.30.5-0.0-1.11.0-1.11.41.50.40.4
Locomotion distance, session 10.10.10.50.70.3-0.00.10.20.10.0-0.2-0.30.3-0.40.50.60.10.4
Locomotion velocity, session 23.23.84.51.81.9-1.8-2.01.9-2.0-2.0-2.12.0-2.02.0-2.0-2.0-2.1-1.6
Locomotion distance, session 21.01.33.71.91.5-1.4-1.41.3-1.2-1.3-1.21.0-1.00.8-0.7-0.7-0.5-0.4
Locomotion velocity, session 30.20.20.60.3-0.10.30.3-0.20.40.40.1-0.60.6-0.60.70.80.40.6
Locomotion distance, session 31.51.73.01.71.6-1.2-1.21.6-1.1-1.3-1.60.9-1.01.0-0.8-0.6-1.6-1.5
Stereotopy head waving bouts, day 30.81.01.9-0.2-0.60.80.8-0.70.71.01.0-1.01.1-1.21.31.31.41.0
Stereotopy head waving duration, day 30.70.91.8-0.6-0.80.80.8-0.90.71.01.1-0.91.0-1.11.11.11.30.8
Locomotion velocity, session 70.10.10.2-0.3-0.30.30.3-0.30.30.30.2-0.30.3-0.30.30.30.20.5
Locomotion distance, session 70.10.10.30.50.5-0.3-0.40.4-0.3-0.4-0.50.1-0.20.2-0.1-0.1-0.4-0.2
Stereotopy head waving bouts, day 70.70.91.81.21.2-0.9-0.91.1-1.0-0.9-1.00.7-0.70.7-0.5-0.4-0.9-1.3
Stereotopy head waving duration, day 70.30.30.70.90.7-0.7-0.70.7-0.7-0.5-0.50.5-0.50.4-0.3-0.3-0.3-0.7
Locomotion velocity, session 80.30.41.20.1-0.30.30.2-0.40.40.40.5-0.60.6-0.70.80.81.01.1
Locomotion distance, session 80.00.10.30.60.2-0.2-0.20.1-0.1-0.0-0.0-0.20.1-0.30.30.40.30.3
Degree of sensitization distance1.11.12.2-1.2-1.21.00.9-1.30.81.01.2-0.90.9-1.00.80.71.31.5
Degree of sensitization stereotypy1.41.52.71.31.4-1.2-1.21.4-1.1-1.2-1.41.0-1.01.1-1.0-0.9-1.4-1.7
Conditioned locomotion0.20.30.7-0.2-0.20.40.6-0.20.50.40.0-0.80.7-0.60.90.8-0.10.4
Cocaine response after cond. corrected2.43.65.0-1.5-1.71.91.9-1.71.81.91.7-2.22.1-2.12.12.21.71.7
Cocaine response after cond. not corrected2.43.54.9-1.3-1.61.81.7-1.71.71.91.8-2.22.0-2.12.12.22.01.8
Cocaine response before conditioning0.60.71.21.00.9-1.1-1.10.8-0.9-0.9-0.60.9-0.90.8-0.8-0.8-0.2-0.7
Saline control response0.20.31.41.20.8-0.6-0.60.6-0.4-0.5-0.50.2-0.20.1-0.00.1-0.2-0.4
Bone: connectivity density1.21.92.71.01.2-1.2-1.41.3-1.3-1.4-1.51.4-1.41.5-1.5-1.6-1.6-1.1
Bone: cortical apparent density0.20.30.9-0.10.2-0.5-0.50.3-0.5-0.5-0.40.7-0.70.7-0.8-0.9-0.5-0.4
Bone: cortical area3.55.66.81.92.3-2.5-2.52.3-2.3-2.5-2.32.4-2.62.5-2.6-2.5-2.2-2.2
Bone: cortical porosity0.10.20.3-0.5-0.50.50.4-0.40.30.40.5-0.30.3-0.30.30.20.40.5
Bone: cortical porosity0.00.00.00.10.00.20.00.00.10.10.0-0.00.1-0.00.10.1-0.0-0.1
Bone: cortical thickness1.83.04.20.81.5-1.8-1.71.5-1.4-1.8-1.61.7-2.02.0-2.1-2.0-1.8-1.8
Bone: cortical thickness0.10.10.5-0.7-0.3-0.00.1-0.30.30.10.3-0.10.0-0.0-0.10.00.0-0.1
Bone: cortical tissue density0.10.20.6-0.20.1-0.4-0.40.2-0.4-0.4-0.30.6-0.60.6-0.7-0.8-0.4-0.2
Condit. Reinf. active minus inactive responses0.60.71.00.80.8-0.9-0.90.8-0.9-0.8-0.81.0-0.90.8-0.8-0.8-0.7-0.6
Condit. Reinf. active-inactive response ratio0.50.50.8-0.9-0.80.70.7-0.80.80.70.8-0.60.6-0.60.60.50.70.5
Condit. Reinf. active responses3.24.15.12.12.0-2.1-2.12.0-2.3-2.0-1.92.2-2.12.0-2.0-1.9-1.7-1.7
Condit. Reinf. inactive responses4.15.36.72.22.3-2.5-2.42.3-2.6-2.3-2.12.5-2.42.3-2.3-2.4-1.8-2.0
Incentive salience index mean4.05.26.82.62.5-2.3-2.42.4-2.4-2.3-2.42.3-2.22.2-2.1-2.0-2.0-1.9
Condit. Reinf. lever presses7.911.917.84.23.9-3.5-3.63.8-3.7-3.5-3.73.2-3.33.1-3.0-2.9-3.0-2.8
Condit. Reinf. active minus inactive responses0.81.21.51.01.1-1.0-1.01.1-1.0-1.2-1.21.1-1.11.1-1.2-1.1-1.2-1.1
Condit. Reinf. active-inactive response ratio0.30.40.90.30.5-0.4-0.50.6-0.5-0.7-0.70.6-0.70.7-0.8-0.8-0.9-0.7
Condit. Reinf. active responses2.33.33.92.01.9-1.9-1.71.9-1.8-2.0-1.91.8-1.81.8-1.8-1.8-1.7-1.5
Condit. Reinf. inactive responses2.74.05.12.12.0-2.3-1.92.0-2.1-2.1-2.02.1-2.12.0-2.0-2.1-1.6-1.5
Condit. Reinf. lever presses3.75.47.22.02.2-2.4-2.22.2-2.4-2.4-2.22.5-2.52.5-2.6-2.7-2.1-1.9
Condit. Reinf. lever reinforcers received2.83.94.52.12.0-2.0-1.92.0-2.0-2.1-2.12.0-2.01.9-1.9-2.0-1.8-1.6
Conditioned reinforcement - actives0.00.10.6-0.0-0.00.60.30.1-0.2-0.1-0.5-0.30.1-0.00.10.1-0.80.1
Conditioned reinforcement - inactives0.20.61.2-0.7-0.71.01.1-0.70.70.70.4-1.10.8-0.80.80.80.30.6
Conditioned locomotion0.10.10.80.10.10.50.30.2-0.10.0-0.6-0.50.3-0.10.30.4-0.9-0.1
Patch foraging indifference point 0 sec0.10.30.90.60.30.40.50.40.20.3-0.4-0.90.7-0.60.90.9-0.20.1
Patch foraging indifference point AUC4.310.314.53.83.5-3.0-3.43.5-3.3-3.4-3.63.0-3.03.0-2.7-2.5-3.2-2.9
Delay disc. indifference point, 0s delay1.61.82.2-1.0-1.31.41.3-1.31.31.51.4-1.31.4-1.41.41.41.41.3
Delay disc. indifference point, 16s delay1.72.43.8-1.0-1.31.61.6-1.31.81.51.1-1.81.7-1.71.81.71.21.9
Delay disc. indifference point, 2s delay0.10.10.30.10.3-0.3-0.40.3-0.5-0.3-0.20.5-0.40.5-0.5-0.5-0.3-0.4
Delay disc. indifference point, 24s delay0.10.10.5-0.4-0.40.30.3-0.40.30.40.3-0.30.3-0.30.20.10.50.7
Delay disc. indifference point, 4s delay0.10.10.7-0.2-0.30.40.4-0.30.40.40.2-0.40.4-0.30.30.20.20.9
Delay disc. indifference point, 8s delay0.00.10.40.10.1-0.0-0.10.1-0.0-0.1-0.30.1-0.20.1-0.2-0.5-0.10.6
Indifference point function ln k1.44.35.3-2.3-2.21.82.2-2.22.12.22.2-2.02.0-2.01.91.82.11.8
Indifference point function log k1.44.35.3-2.3-2.21.82.2-2.22.12.22.2-2.02.0-2.01.91.82.11.8
Patch foraging total patch changes 0 sec0.10.31.11.00.80.00.00.8-0.2-0.2-0.8-0.50.2-0.10.40.5-0.7-0.4
Patch foraging total patch changes 12 sec2.23.04.01.81.9-1.4-1.72.0-1.7-1.7-2.01.5-1.51.7-1.5-1.4-2.0-2.0
Patch foraging total patch changes 18 sec0.30.71.51.21.0-0.7-0.81.0-0.9-0.9-1.00.7-0.70.7-0.6-0.6-0.8-0.7
Patch foraging total patch changes 24 sec0.82.64.32.11.9-1.3-1.71.9-1.7-1.7-2.01.3-1.31.4-1.2-1.0-1.8-1.6
Patch foraging total patch changes 6 sec1.42.34.72.22.0-1.1-1.42.0-1.6-1.5-2.00.8-1.11.2-0.9-0.8-1.9-1.3
Patch foraging time to switch 0 sec0.83.25.7-2.4-2.11.61.7-2.11.71.82.1-1.51.4-1.51.31.11.81.9
Patch foraging water rate 0 sec0.51.93.71.81.7-1.1-1.01.8-1.1-1.3-1.80.8-0.91.1-0.7-0.5-1.7-1.9
Patch foraging water rate 12 sec0.00.10.20.0-0.00.20.2-0.00.20.20.1-0.50.3-0.30.40.40.2-0.0
Patch foraging water rate 18 sec0.40.92.00.60.9-0.8-0.81.0-0.6-1.0-1.10.8-0.91.0-1.0-0.8-1.3-1.4
Patch foraging water rate 24 sec0.20.31.2-0.20.2-0.3-0.30.3-0.3-0.5-0.70.5-0.50.7-0.6-0.6-1.1-0.6
Patch foraging water rate 6 sec0.40.61.61.00.9-1.1-0.90.8-0.5-0.8-0.80.7-0.60.6-0.5-0.3-0.6-1.3
Seeking ratio, delayed vs. immediate footshock3.34.76.81.92.3-2.2-1.82.4-2.2-2.1-2.51.8-2.22.2-2.1-2.2-2.6-2.0
Distance traveled before self-admin1.12.45.02.22.0-2.0-1.61.8-1.4-1.5-1.81.3-1.41.2-1.0-0.9-1.2-1.2
Distance traveled after self-admin1.01.83.21.11.2-1.8-1.41.1-1.4-1.4-1.41.5-1.51.3-1.3-1.4-1.0-0.6
Extensor digitorum longus weight4.517.823.34.84.7-4.3-4.34.7-4.2-4.4-4.73.9-4.04.0-3.7-3.6-4.1-3.7
Bone: elastic displacement3.24.17.3-2.7-2.42.22.2-2.32.42.12.2-1.81.9-1.71.61.61.51.4
Bone: elastic work0.50.63.4-1.8-1.20.80.8-1.01.00.60.8-0.20.2-0.0-0.2-0.20.00.2
Bone: endosteal estimation0.71.63.41.91.5-1.3-1.61.4-1.4-1.3-1.31.1-1.11.0-1.0-0.8-0.8-1.2
Bone: endosteal perimeter0.61.43.11.81.5-1.2-1.41.4-1.3-1.2-1.30.8-0.90.9-0.8-0.7-1.0-1.1
Epididymis fat weight0.31.51.91.21.2-1.3-1.41.2-1.4-1.2-1.11.4-1.31.3-1.3-1.3-0.9-1.0
Delta time in closed arm before/after self-admin1.21.12.00.40.8-1.2-1.00.9-1.3-1.0-0.81.1-1.31.2-1.3-1.4-0.9-1.1
Delta time in open arm before/after self-admin0.60.72.9-0.4-0.71.00.8-0.70.90.70.5-0.90.8-0.80.90.60.71.7
Diff in mean of infusions in LGA sessions0.00.00.1-0.4-0.2-0.1-0.1-0.2-0.30.00.20.2-0.20.1-0.3-0.30.20.2
Delay discount exponential model param0.60.92.50.70.8-1.0-0.90.8-1.0-0.9-0.61.0-1.00.9-0.9-0.7-0.7-1.6
Extinction: sum of active levers before priming3.24.99.2-2.1-2.22.22.3-2.22.12.32.1-2.32.2-2.22.11.72.03.0
Active lever presses in extinction session 60.30.30.6-0.7-0.60.80.6-0.50.40.60.3-0.80.6-0.60.60.50.20.8
Bone: final force1.62.73.91.71.7-1.9-2.01.6-1.6-1.8-1.41.8-1.81.6-1.7-1.7-0.9-1.1
Bone: final moment1.52.43.51.51.5-1.8-1.91.4-1.5-1.7-1.31.7-1.71.6-1.7-1.7-0.8-1.0
Food consumed during 24 hour testing period0.30.51.01.00.9-1.0-0.90.8-0.7-0.8-0.80.6-0.70.6-0.5-0.5-0.4-0.4
Glucose2.43.84.92.22.2-2.0-1.92.2-2.1-2.0-2.11.8-1.81.8-1.7-1.5-1.8-2.0
Heart weight0.61.01.61.11.1-1.0-1.21.0-1.3-1.0-0.80.9-1.11.0-1.0-1.2-0.7-0.4
Delay discount hyperbolic model param0.40.61.90.50.6-0.8-0.70.6-0.8-0.8-0.50.8-0.80.7-0.7-0.6-0.5-1.4
Intermittent access intake day 1-15 change0.31.52.50.91.1-1.4-1.21.2-1.2-1.1-1.11.2-1.21.2-1.2-1.1-1.2-1.6
Intermittent access intake escalation0.31.42.30.81.0-1.4-1.11.1-1.1-1.1-1.11.2-1.21.2-1.2-1.1-1.1-1.5
Intermittent access intake escalation 21.62.64.50.91.3-1.8-1.51.4-1.5-1.5-1.51.7-1.81.7-1.8-1.7-1.7-2.1
Intermitt. access day 1 inactive lever presses0.11.22.01.31.3-1.4-1.01.2-1.2-1.0-1.20.9-1.00.9-0.8-0.8-1.0-1.1
Intermitt. access day 15 inactive lever presses0.00.00.20.10.2-0.50.10.1-0.10.0-0.3-0.2-0.1-0.10.20.00.10.1
Intermitt. access escalation Index0.10.30.90.90.7-0.8-0.70.6-0.6-0.3-0.20.4-0.30.3-0.3-0.10.2-1.0
Intermittent access day 1 total infusions1.13.25.6-1.5-1.62.42.1-1.51.71.81.1-2.32.0-1.81.91.80.91.5
Intermittent access day 15 total infusions0.00.10.7-0.00.20.10.00.3-0.3-0.1-0.5-0.1-0.10.3-0.2-0.2-0.8-0.6
Intermittent access terminal intake (last 3 days)0.10.20.80.00.20.10.10.3-0.2-0.1-0.6-0.2-0.10.2-0.2-0.1-0.9-0.9
Intermittent access total infusions0.10.10.6-0.00.10.60.30.2-0.00.1-0.5-0.60.3-0.10.20.2-0.8-0.4
Intermittent access day 1 locomotion1.22.24.4-1.2-1.32.11.9-1.21.41.40.7-1.91.6-1.51.51.50.31.6
Intermittent access day 15 total locomotion0.41.63.0-1.2-1.21.71.6-1.01.21.20.7-1.61.4-1.31.31.30.20.9
Intermittent access total locomotion1.11.32.8-1.5-1.21.71.5-1.01.11.10.6-1.41.2-1.00.90.9-0.10.8
Intermittent access standard deviation0.10.30.60.40.6-0.6-0.30.7-0.6-0.5-0.80.2-0.50.5-0.4-0.4-0.7-0.7
Left kidney weight0.10.93.01.71.4-1.1-1.11.2-1.0-1.0-1.10.6-0.80.6-0.5-0.6-0.5-0.2
Right kidney weight0.21.52.21.51.4-1.2-1.31.3-1.3-1.4-1.41.1-1.31.2-1.2-1.4-1.2-0.0
Cocaine induced anxiety0.10.20.5-0.4-0.50.30.4-0.50.50.50.7-0.20.5-0.50.50.60.70.2
Post-drug Anxiety0.10.20.80.90.5-0.4-0.60.4-0.3-0.30.10.5-0.20.2-0.1-0.10.3-0.0
Baseline Anxiety0.50.91.21.00.9-1.0-1.10.9-1.1-1.0-0.90.9-1.00.9-0.9-1.1-0.6-0.1
Tail length1.16.19.23.02.7-2.7-2.92.6-2.6-2.7-2.52.4-2.42.3-2.2-2.0-2.1-1.8
Length with tail0.83.58.22.92.4-1.8-2.22.2-1.9-2.0-2.11.4-1.51.4-1.3-1.1-1.6-1.2
Length without tail0.00.20.60.40.00.50.3-0.00.40.40.0-0.70.6-0.60.70.70.30.4
Times rat made contact with spout0.70.71.10.60.8-0.9-0.80.8-0.7-0.8-0.90.8-0.90.9-1.0-0.9-1.0-1.0
Lifetime Intake0.20.31.0-0.1-0.10.90.7-0.00.30.4-0.3-1.00.6-0.50.60.6-0.6-0.1
Liver weight, left0.10.10.4-0.1-0.30.20.1-0.30.20.30.5-0.40.3-0.40.20.20.60.7
Liver weight, right0.61.01.6-1.3-1.21.11.1-1.11.21.01.0-0.90.9-0.90.80.70.71.0
Locomotor activity0.00.00.10.10.0-0.1-0.1-0.0-0.00.0-0.0-0.1-0.0-0.00.0-0.10.00.4
Locomotor testing distance0.30.81.1-0.2-0.60.70.8-0.80.70.90.8-1.01.0-1.01.11.01.01.1
Locomotor testing rearing0.10.41.31.10.8-0.9-0.60.7-0.7-0.6-0.50.5-0.50.4-0.4-0.3-0.2-0.3
Locomotion in novel chamber0.10.10.4-0.6-0.40.30.1-0.20.20.10.20.0-0.10.2-0.4-0.4-0.40.2
Locomotion in novel chamber post-restriction1.13.24.61.21.5-1.7-2.01.5-1.7-1.8-1.42.1-2.02.0-2.1-2.1-1.6-1.9
Fecal boli incidents, locomotor time 10.20.41.4-1.0-0.80.60.7-0.70.60.70.6-0.40.5-0.40.30.10.41.2
Change in fecal boli incidents, locomotor task0.30.41.81.00.7-0.2-0.60.6-0.5-0.5-0.60.2-0.10.2-0.10.3-0.5-1.3
Time >=10cm from walls, locomotor time 10.20.20.80.30.00.20.4-0.10.60.40.3-0.50.5-0.50.60.90.40.1
Bouts of movement, locomotor time 11.41.93.3-1.5-1.51.41.2-1.51.21.41.5-1.11.3-1.21.21.01.21.8
Total resting periods, locomotor time 11.61.93.1-1.8-1.61.41.3-1.61.21.41.6-1.01.2-1.11.00.81.31.7
Rest time, locomotor task time 10.20.31.8-1.3-0.90.20.0-0.8-0.00.30.70.4-0.00.1-0.3-0.40.40.2
Distance moved, locomotor task time 10.20.62.81.71.2-0.6-0.61.1-0.2-0.7-1.00.2-0.30.3-0.10.1-0.7-0.7
Vertical activity count, locomotor time 10.00.31.91.40.6-0.0-0.10.40.50.1-0.1-0.40.4-0.50.60.90.5-0.1
Time >=10cm from walls, locomotor time 20.00.00.10.30.2-0.30.00.2-0.3-0.1-0.1-0.0-0.1-0.0-0.0-0.10.10.2
Bouts of movement, locomotor time 20.10.50.80.80.8-0.7-0.60.8-0.9-0.7-0.80.6-0.60.6-0.5-0.7-0.80.2
Total resting periods, locomotor time 20.00.20.40.40.4-0.3-0.30.5-0.5-0.4-0.50.3-0.40.4-0.3-0.4-0.60.3
Rest time, locomotor task time 20.40.71.1-1.0-1.01.00.7-1.00.90.81.0-0.50.8-0.70.70.90.80.3
Distance moved, locomotor task time 20.70.91.60.70.8-1.2-1.00.8-0.9-0.9-0.81.0-1.21.0-1.1-1.3-0.6-0.6
Vertical activity count, locomotor time 20.10.30.91.00.7-0.9-0.60.5-0.4-0.4-0.30.5-0.60.3-0.5-0.50.0-0.3
Light reinforcement 10.10.51.71.30.6-0.40.20.20.20.2-0.1-0.80.6-0.81.11.20.70.8
Light reinforcement 20.51.13.50.7-0.20.80.6-0.40.80.90.7-1.21.3-1.41.61.91.20.9
Bone: marrow area0.82.03.71.91.7-1.5-1.71.5-1.5-1.4-1.41.3-1.21.2-1.2-1.0-1.0-1.4
Bone: maximum diameter2.85.66.92.32.4-2.4-2.62.4-2.5-2.4-2.32.3-2.42.4-2.4-2.4-2.0-2.1
Bone: maximum force3.16.17.72.52.6-2.7-2.82.5-2.5-2.7-2.42.6-2.62.5-2.5-2.5-1.9-1.7
Bone: maximum moment2.85.36.72.32.3-2.5-2.62.2-2.3-2.5-2.22.4-2.52.3-2.4-2.4-1.7-1.6
Mean time between licks in bursts0.10.82.8-0.7-1.00.60.5-1.10.70.81.3-0.60.6-0.80.60.51.71.3
Mean num. licks in bursts0.92.53.1-1.7-1.81.81.6-1.71.71.61.6-1.51.5-1.51.41.31.41.6
Cd content in liver0.50.61.11.00.9-0.9-1.00.8-0.8-0.8-0.70.6-0.70.6-0.5-0.3-0.4-0.9
Co content in liver1.11.32.2-0.6-0.91.01.0-1.11.31.11.3-1.01.2-1.31.31.41.51.0
Cu content in liver1.62.03.2-1.6-1.61.21.2-1.61.31.41.8-1.11.3-1.31.21.11.71.2
Fe content in liver1.82.33.8-1.0-1.31.31.4-1.51.71.41.3-1.51.5-1.71.71.71.41.9
K content in liver0.60.60.9-0.3-0.60.80.7-0.70.70.80.7-0.70.8-0.90.90.90.80.8
Mg content in liver0.60.71.4-0.8-0.91.20.8-0.80.91.00.9-0.80.9-0.80.60.70.90.5
Mn content in liver1.82.02.71.11.3-1.4-1.51.3-1.5-1.5-1.31.5-1.61.5-1.6-1.6-1.3-1.3
Na content in liver1.82.04.5-1.3-1.51.11.0-1.71.41.42.0-1.01.2-1.41.11.12.11.4
Rb content in liver5.96.99.1-2.6-2.82.62.5-2.83.02.72.8-2.42.6-2.62.42.52.72.4
Se content in liver2.83.35.21.51.8-1.9-1.91.8-2.3-1.9-1.71.7-1.91.9-1.9-2.0-1.7-1.4
Sr content in liver0.40.31.00.60.6-0.4-0.40.7-1.0-0.5-0.40.4-0.60.6-0.6-0.8-0.3-0.2
Zn content in liver0.10.10.40.30.2-0.4-0.50.2-0.3-0.3-0.20.6-0.40.4-0.5-0.4-0.3-0.1
Bone: minimum diameter0.00.10.2-0.20.1-0.0-0.40.1-0.3-0.2-0.10.2-0.30.3-0.4-0.4-0.3-0.3
Time in familiar zone, hab. session 10.40.41.2-0.7-0.1-0.2-0.20.2-0.3-0.4-0.20.7-0.70.9-1.0-1.1-0.9-0.9
Time in novel zone, hab. session 14.24.67.5-1.1-1.81.81.8-2.02.02.02.1-2.12.2-2.42.52.42.72.7
Total zone transitions, hab. session 10.00.00.00.10.0-0.1-0.20.0-0.2-0.10.00.2-0.20.1-0.1-0.20.10.2
Total locomotion distance, hab. session 10.91.32.20.70.8-1.1-1.20.9-1.3-1.1-0.81.4-1.31.3-1.4-1.5-0.7-0.9
Locomotion velocity, hab. session 12.33.34.41.61.7-1.8-1.91.7-2.1-1.8-1.62.1-2.01.9-2.0-2.1-1.4-1.5
Time in familiar zone, hab. session 20.10.20.9-0.9-0.60.30.3-0.50.20.30.50.1-0.00.1-0.2-0.40.20.3
Time in novel zone, hab. session 22.62.84.4-1.0-1.41.61.6-1.51.81.61.5-1.91.9-1.92.02.11.61.5
Total zone transitions, hab. session 20.20.31.11.00.7-0.5-0.60.6-0.5-0.5-0.60.3-0.30.2-0.2-0.1-0.3-0.1
Total locomotion distance, hab. session 20.81.11.51.21.1-1.1-1.11.1-1.2-1.0-1.01.0-1.01.0-0.9-0.9-0.9-0.9
Locomotion velocity, hab. session 21.11.52.11.41.3-1.2-1.31.3-1.4-1.3-1.21.2-1.21.2-1.2-1.1-1.1-1.1
Novel to familiar place preference ratio4.25.56.4-1.9-2.22.42.3-2.22.52.42.3-2.42.5-2.42.52.42.32.3
Novelty place preference5.26.77.9-2.3-2.52.62.6-2.52.82.72.6-2.62.7-2.72.62.62.52.4
Time in novel zone, NPP test6.88.29.5-2.5-2.82.92.8-2.83.12.92.9-2.93.0-3.02.92.92.82.8
Total zone transitions, NPP test0.20.31.41.20.8-0.6-0.60.6-0.6-0.5-0.60.3-0.40.2-0.1-0.1-0.20.0
Total locomotion distance, NPP test1.21.63.51.91.6-1.3-1.31.5-1.4-1.3-1.51.0-1.11.0-0.8-0.7-1.2-1.1
Locomotion velocity, NPP test1.92.74.62.11.9-1.6-1.61.9-1.8-1.7-1.91.4-1.41.4-1.2-1.1-1.7-1.5
Intraocular pressure1.62.64.32.12.0-1.5-1.61.9-1.6-1.6-1.91.2-1.41.4-1.2-1.0-1.6-1.9
Delta distance traveled before/after self-admin0.00.00.2-0.3-0.3-0.0-0.0-0.3-0.10.00.20.2-0.10.0-0.1-0.10.40.2
Delta ambulatory time before/after self-admin0.20.40.9-0.9-0.90.50.4-0.90.40.50.8-0.30.4-0.50.30.20.90.7
Parametrial fat weight0.30.61.1-0.3-0.50.50.7-0.70.80.60.7-1.00.8-1.01.01.01.01.0
Pavlov. Cond. lever latency5.97.410.2-3.2-3.02.82.8-3.03.02.82.9-2.52.6-2.52.42.42.52.3
Pavlov. Cond. magazine entry latency0.60.71.10.90.9-1.0-0.90.8-1.0-0.9-0.90.9-0.90.8-0.9-1.0-0.6-0.3
Pavlov. Cond. change in total contacts2.32.53.71.91.8-1.6-1.61.7-1.7-1.6-1.81.4-1.51.4-1.3-1.3-1.5-1.3
Pavlov. Cond. index score3.24.05.22.22.1-2.1-2.12.1-2.3-2.1-2.02.0-2.01.9-1.9-2.0-1.6-1.4
Pavlov. Cond. latency score2.93.64.72.12.0-1.9-1.92.0-2.2-2.0-2.01.9-1.91.8-1.8-1.9-1.6-1.4
Pavlov. Cond. lever contacts5.87.09.13.02.9-2.7-2.72.9-2.8-2.7-2.92.5-2.62.5-2.4-2.4-2.5-2.2
Pavlov. Cond. magazine entry number0.91.21.4-1.0-1.11.21.0-1.11.21.11.1-1.11.1-1.11.11.10.90.8
Pavlov. Cond. intertrial magazine entries0.20.30.50.60.5-0.5-0.60.5-0.6-0.5-0.50.7-0.60.5-0.5-0.5-0.4-0.3
Pavlov. Cond. lever-magazine prob. diff.3.54.45.72.22.1-2.2-2.12.1-2.4-2.1-2.12.1-2.22.1-2.1-2.1-1.8-1.5
Pavlov. Cond. response bias3.84.76.02.52.3-2.3-2.22.3-2.4-2.3-2.32.1-2.22.0-2.0-2.0-1.9-1.6
Pavlov. Cond. lever latency3.44.86.0-2.0-2.12.32.2-2.12.32.32.1-2.42.4-2.32.32.41.91.8
Pavlov. Cond. magazine entry latency0.10.20.6-0.5-0.60.30.4-0.60.30.30.6-0.10.1-0.20.1-0.10.70.8
Pavlov. Cond. change in total contacts1.02.54.71.01.2-1.7-1.61.2-1.7-1.6-1.22.0-1.91.8-2.0-2.2-1.0-1.1
Pavlov. Cond. index score0.60.92.00.50.6-1.0-0.90.6-1.0-1.0-0.61.2-1.21.1-1.3-1.4-0.5-0.5
Pavlov. Cond. latency score0.81.22.50.60.8-1.1-1.00.8-1.2-1.1-0.81.4-1.41.3-1.5-1.6-0.8-0.8
Pavlov. Cond. lever contacts2.53.74.91.71.8-2.0-1.91.8-2.1-2.0-1.72.1-2.12.0-2.1-2.2-1.5-1.5
Pavlov. Cond. magazine entry number0.50.61.7-0.2-0.40.80.6-0.40.80.80.4-1.11.0-1.01.21.30.40.4
Pavlov. Cond. intertrial magazine entries0.20.41.10.70.7-0.5-0.60.7-0.5-0.5-0.70.4-0.40.5-0.5-0.3-0.8-1.0
Pavlov. Cond. lever-magazine prob. diff.0.61.02.30.50.6-1.0-0.90.7-1.0-1.0-0.61.3-1.31.2-1.4-1.5-0.5-0.6
Pavlov. Cond. response bias1.42.03.51.11.2-1.5-1.41.2-1.5-1.4-1.11.7-1.61.5-1.7-1.9-0.9-0.9
Time in closed arm before self-admin0.20.30.6-0.7-0.60.70.8-0.50.70.50.4-0.50.6-0.40.50.5-0.20.3
Time in closed arm after self-admin0.10.10.6-0.6-0.2-0.20.0-0.1-0.2-0.10.20.3-0.30.3-0.3-0.3-0.3-0.8
Time in open arm before self-admin0.40.51.61.30.9-0.6-0.90.8-0.8-0.6-0.60.4-0.50.4-0.4-0.2-0.2-0.9
Time in open arm after self-admin0.30.31.41.20.8-0.2-0.50.8-0.5-0.5-0.90.2-0.30.3-0.2-0.3-0.50.2
Bone: periosteal estimation1.74.05.32.12.1-2.1-2.32.0-2.0-2.1-2.01.9-2.01.9-2.0-1.8-1.6-1.8
Bone: periosteal perimeter0.40.71.11.11.0-0.9-1.01.0-0.9-0.9-0.90.6-0.70.7-0.7-0.6-0.7-0.7
Bone: post-yield work1.22.04.62.11.7-1.5-1.61.6-1.6-1.5-1.51.3-1.31.1-1.0-1.0-0.9-0.9
Progressive ratio test 1 active lever presses0.81.53.6-0.8-0.91.61.5-0.81.21.30.4-1.91.5-1.31.41.50.10.5
Progressive ratio test 1 breakpoint0.71.23.0-0.7-0.81.41.4-0.71.11.10.3-1.71.3-1.21.31.3-0.00.4
Progressive ratio test 1 inactive lever presses0.10.20.80.90.6-0.10.10.5-0.1-0.1-0.7-0.50.2-0.20.40.5-0.5-0.3
Progressive ratio test 2 active lever presses1.42.04.1-0.9-1.21.91.8-1.11.31.50.7-2.01.7-1.61.61.60.50.9
Progressive ratio test 2 breakpoint1.72.24.3-1.0-1.22.01.8-1.11.41.50.7-2.11.7-1.61.71.70.61.0
Progressive ratio test 2 inactive lever presses0.00.10.60.20.20.30.10.3-0.2-0.1-0.6-0.30.00.10.00.1-0.8-0.5
Incentive Sensitization - Responses0.30.91.4-0.6-0.81.11.2-0.81.01.00.7-1.11.1-1.11.11.10.70.8
Incentive Sensitization - Breakpoint0.41.01.5-0.6-0.81.11.2-0.81.01.00.8-1.21.1-1.11.11.10.70.8
Sum of active levers in priming session hrs 5-65.04.76.0-1.8-2.02.32.3-2.02.02.31.9-2.42.3-2.32.42.31.72.3
Progressive ratio0.00.00.2-0.0-0.00.10.1-0.00.00.1-0.1-0.30.0-0.10.0-0.1-0.10.5
Food seeking constrained by brief footshock4.05.110.63.32.9-1.9-2.22.8-2.2-2.2-2.71.6-1.81.9-1.6-1.4-2.3-1.9
Seeking ratio, punishment vs. effort0.81.73.21.81.6-1.2-1.31.6-1.3-1.3-1.31.2-1.11.2-1.0-0.8-1.1-1.5
Retroperitoneal fat weight0.21.02.0-1.4-1.20.80.9-1.20.91.01.4-0.80.7-0.80.60.51.41.0
Reaction time number correct0.00.00.20.40.30.1-0.10.20.1-0.2-0.3-0.10.0-0.00.10.1-0.20.2
Reaction time mean minus median0.32.24.80.50.9-1.6-1.31.0-1.6-1.4-0.91.9-1.81.8-2.0-2.2-0.8-1.1
Reaction time mean minus median AUC0.42.84.91.01.3-1.7-1.61.4-1.9-1.7-1.22.1-1.91.9-2.1-2.2-1.1-1.3
Reaction time num false alarms0.10.20.60.20.3-0.4-0.50.3-0.3-0.4-0.40.7-0.60.6-0.7-0.8-0.50.1
Reaction time num false alarms AUC0.30.60.90.80.8-0.8-0.80.8-0.6-0.8-0.90.9-0.80.8-0.8-0.9-0.9-0.2
Reaction time trials correct on left0.00.00.20.40.30.1-0.10.20.1-0.2-0.3-0.10.0-0.00.10.1-0.20.2
Reaction time trials on left0.00.00.10.30.20.20.00.10.2-0.1-0.2-0.10.1-0.10.20.2-0.10.3
Reaction time mean0.20.52.0-1.4-1.10.20.5-1.00.30.51.10.10.0-0.2-0.2-0.30.90.3
Reaction time mean AUC0.20.52.3-1.5-1.20.30.6-1.10.40.61.10.00.1-0.2-0.2-0.20.90.5
Median of all reaction times1.32.04.3-2.1-1.91.11.4-1.91.31.51.9-0.91.0-1.20.80.81.71.1
Reaction time omissions1.42.33.2-1.8-1.71.31.4-1.71.21.61.8-1.31.4-1.41.41.31.81.4
Reaction time false alarm rate0.10.10.3-0.10.0-0.3-0.30.1-0.1-0.1-0.10.5-0.30.3-0.4-0.5-0.30.1
Reaction time premature initiation rate1.11.74.3-2.1-1.61.21.5-1.41.51.51.4-1.21.1-1.00.90.91.20.4
Reaction time premature initiations0.41.32.7-1.7-1.31.11.4-1.21.41.31.1-1.11.0-0.90.90.90.90.4
Std. dev. reaction times0.20.61.8-0.30.0-0.8-0.50.1-0.9-0.50.01.2-1.00.9-1.2-1.40.1-0.4
Reaction time trials completed0.00.00.10.30.20.20.00.10.2-0.1-0.2-0.10.1-0.10.20.2-0.10.3
Reaction time trials AUC0.00.00.10.30.20.2-0.00.10.2-0.1-0.2-0.10.1-0.10.10.2-0.10.2
Run reversals in cocaine runway, females0.20.20.50.20.2-0.3-0.40.2-0.0-0.5-0.10.6-0.60.5-0.7-0.6-0.2-0.7
Run reversals in cocaine runway, males0.00.00.1-0.3-0.20.30.3-0.10.10.20.0-0.20.2-0.10.1-0.1-0.10.3
Latency to leave start box in cocaine runway0.60.91.30.81.0-1.1-0.90.9-0.9-1.0-1.10.8-0.90.9-0.9-0.8-1.1-0.9
Latency to leave start box in cocaine runway, F0.10.20.4-0.4-0.30.30.6-0.30.40.30.1-0.70.4-0.50.50.50.00.5
Latency to leave start box in cocaine runway, M2.01.92.71.71.6-1.6-1.51.5-1.3-1.4-1.41.4-1.31.3-1.2-1.0-1.2-1.4
Std. dev. time between licks in bursts0.20.40.8-0.6-0.70.70.5-0.70.60.60.7-0.50.5-0.50.50.40.60.9
Total sessions with >9 infusions0.40.51.5-0.0-0.30.90.9-0.30.60.6-0.2-1.20.9-0.91.01.0-0.20.6
Short access day 1 total inactive lever presses0.10.30.70.80.6-0.30.00.50.1-0.2-0.8-0.40.1-0.20.30.7-0.8-0.8
Short access day 10 total inactive lever presses0.11.01.80.91.1-1.4-0.91.0-1.2-0.9-1.01.0-1.00.9-0.9-0.8-0.7-1.2
Short access day 1 total infusions0.30.51.70.1-0.20.80.8-0.30.50.6-0.1-1.30.9-0.91.01.2-0.10.2
Short access day 10 total infusions0.50.92.0-0.2-0.51.11.1-0.51.00.90.3-1.41.2-1.11.21.40.20.4
Short access total infusions1.01.43.3-0.5-0.81.51.4-0.81.21.20.4-1.81.4-1.41.51.60.30.7
Short access day 1 locomotion1.42.44.6-1.3-1.41.71.9-1.41.71.60.8-2.21.6-1.61.51.60.51.6
Short access day 10 total locomotion0.10.61.4-1.2-0.91.01.0-0.80.50.70.4-0.80.6-0.50.40.3-0.01.1
Short access total locomotion0.60.91.7-0.6-0.71.21.1-0.80.90.90.3-1.31.1-1.01.01.1-0.01.1
One hour access (0.3 mA shock)0.10.10.50.50.20.70.10.3-0.1-0.0-0.3-0.40.3-0.10.20.3-0.4-0.3
Compulsive drug intake0.50.71.90.50.6-0.7-0.90.7-0.7-0.9-0.51.1-1.01.0-1.1-1.4-0.5-0.2
One hour access (shock baseline)0.20.51.50.1-0.21.10.8-0.20.30.6-0.1-1.21.0-0.91.01.2-0.00.0
Social response proportion1.51.94.3-1.6-1.71.11.0-1.71.11.42.1-0.81.0-1.10.90.72.01.3
Social responses0.60.81.21.11.0-1.0-1.10.9-1.1-0.9-0.71.0-1.00.9-0.9-0.9-0.5-0.6
Social time0.30.41.9-0.2-0.60.20.2-0.70.30.51.0-0.20.3-0.60.50.41.41.2
Soleus weight0.51.53.00.2-0.50.80.7-0.81.01.01.0-1.41.4-1.51.71.71.71.7
Bone: stiffness3.76.79.32.82.7-3.0-3.12.5-2.7-2.8-2.42.7-2.82.5-2.6-2.6-1.6-1.6
Tibialis anterior weight6.120.932.45.75.3-4.9-4.85.1-4.6-4.8-5.04.1-4.24.1-3.7-3.4-4.2-4.2
Time to tail flick, vehicle, before self-admin0.10.20.6-0.7-0.50.70.5-0.40.20.30.3-0.30.4-0.10.20.2-0.4-0.1
Time to tail flick, vehicle, after self-admin0.10.10.40.00.3-0.3-0.20.3-0.2-0.2-0.30.2-0.30.4-0.4-0.5-0.6-0.6
Time to tail flick, test, before self-admin0.40.50.90.80.7-0.4-0.90.8-0.8-0.7-0.50.7-0.60.7-0.7-0.5-0.8-0.9
Time to tail flick, test, after self-admin4.24.55.51.51.9-1.8-2.22.0-2.2-2.2-2.12.2-2.22.3-2.3-2.3-2.2-2.2
Delta time to tail flick, vehicle, before/after SA0.10.10.30.40.3-0.6-0.40.3-0.2-0.2-0.10.3-0.50.3-0.4-0.50.2-0.2
Delta time to tail flick, test, before/after SA0.20.30.6-0.10.2-0.6-0.30.3-0.4-0.5-0.70.5-0.60.6-0.6-0.8-0.6-0.2
Tibia length0.20.61.60.2-0.30.30.2-0.60.70.50.6-0.80.7-1.01.01.21.21.3
Ambulatory time before self-admin0.51.73.81.91.7-1.6-1.31.5-1.1-1.3-1.70.9-1.10.9-0.8-0.7-1.2-0.9
Ambulatory time after self-admin0.20.40.70.70.6-0.8-0.70.5-0.6-0.6-0.80.6-0.60.5-0.4-0.4-0.50.1
Bone: tissue strength0.20.20.40.50.2-0.6-0.50.1-0.4-0.30.10.6-0.50.3-0.5-0.60.60.5
Total heroin consumption2.83.34.8-1.2-1.51.71.9-1.61.81.91.4-2.22.0-2.02.12.01.62.0
Bone: trabecular number1.42.63.21.31.5-1.5-1.81.6-1.7-1.7-1.61.7-1.71.7-1.7-1.8-1.6-1.3
Bone: trabecular spacing0.00.00.2-0.00.1-0.3-0.00.1-0.1-0.1-0.10.3-0.20.2-0.3-0.2-0.1-0.4
Bone: trabecular thickness0.00.00.2-0.4-0.30.30.1-0.2-0.00.10.1-0.1-0.00.0-0.1-0.2-0.10.3
Bone: trabecular tissue density1.93.35.62.42.0-2.2-2.01.8-2.0-2.0-1.71.9-1.91.6-1.6-1.6-0.9-1.1
Water consumed over 24 hours0.61.21.70.91.2-1.1-1.11.2-0.9-1.2-1.21.0-1.11.1-1.1-1.1-1.3-1.3
Number of responses in last shaping day1.72.14.9-0.2-0.81.11.4-1.01.31.50.9-2.01.8-1.92.02.21.21.3