Hub : Genes

Tesk1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Tesk1 0.05 0.04 1.2e-05 0.06 0.04 0.05 0.05 1.1e-06 1.7e-05 3.1e-06 4.5e-06
2 Eye gene expression Tesk1 0.32 0.17 1.5e-03 0.15 0.13 0.16 -0 2.7e-03 5.0e-03 2.0e-03 3.3e-01
3 Brain intron excision ratio chr5_57695044_57695204 0.07 0.08 6.2e-03 0.04 0.03 0.05 0.03 1.5e-04 1.5e-03 2.8e-05 3.4e-04
4 pVTA gene expression Tesk1 0.21 0.1 1.0e-11 0.25 0.16 0.27 0.16 2.6e-11 2.9e-07 3.5e-12 2.3e-07
5 NAcc mRNA stability Tesk1 0.03 0.02 2.4e-05 0.04 0.04 0.02 0.04 9.5e-06 1.4e-05 2.1e-03 2.1e-05
6 Brain mRNA stability Tesk1 0.1 0.06 5.2e-10 0.11 0.1 0.11 0.05 1.3e-10 3.0e-09 2.9e-10 2.8e-05
7 Brain gene expression Tesk1 0.3 0.12 0.0e+00 0.37 0.38 0.37 0.32 2.8e-36 2.5e-37 3.2e-36 1.6e-30
8 LHb mRNA stability Tesk1 0.16 0.1 8.0e-04 0.14 0.1 0.13 0.11 4.2e-04 2.8e-03 5.2e-04 1.7e-03
9 OFC gene expression Tesk1 0.24 0.12 2.6e-05 0.2 0.09 0.16 0.18 1.5e-05 4.9e-03 9.8e-05 5.2e-05
10 NAcc gene expression Tesk1 0.39 0.14 0.0e+00 0.26 0.26 0.27 0.27 5.9e-30 1.9e-29 4.7e-31 9.0e-31
11 PL gene expression Tesk1 0.26 0.11 0.0e+00 0.34 0.34 0.35 0.34 2.7e-38 1.4e-38 4.2e-40 4.7e-39
12 Liver gene expression Tesk1 0.02 0.02 4.3e-03 0.02 0.02 0.01 0.02 2.4e-03 2.5e-03 3.9e-02 4.7e-03
13 IL gene expression Tesk1 0.31 0.14 2.7e-07 0.25 0.22 0.26 0.27 8.6e-07 4.1e-06 4.9e-07 3.1e-07
14 BLA gene expression Tesk1 0.64 0.21 0.0e+00 0.37 0.42 0.44 0.42 1.1e-20 2.0e-24 1.7e-25 6.2e-24
15 LHb gene expression Tesk1 0.36 0.17 8.5e-05 0.13 0.12 0.1 0.14 5.7e-04 7.5e-04 2.8e-03 4.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.42.33.9-1.5-1.61.6-1.6-1.4-1.61.6-1.5-1.5-1.4-1.5-1.61.6-2.00.4
Area under the delay curve0.70.82.10.50.7-0.60.91.01.0-0.90.50.51.11.00.8-0.81.5-0.8
BMI with tail3.09.914.1-2.6-3.33.2-3.3-3.1-3.13.2-3.4-3.4-2.8-3.1-3.53.4-3.81.0
BMI without tail5.511.316.5-4.0-4.13.3-3.7-3.5-3.63.4-3.4-3.4-3.2-3.2-3.53.1-3.2-0.6
Body weight3.414.219.1-4.1-4.44.1-4.0-3.9-3.83.8-4.0-4.0-3.3-3.5-3.93.5-4.0-0.3
Weight adjusted by age0.20.31.5-0.6-0.41.0-0.0-0.30.1-0.1-0.3-0.30.60.30.1-0.20.1-1.2
Bone surface0.61.11.9-1.3-1.31.4-1.1-0.9-1.01.0-1.0-1.0-0.7-0.9-1.11.0-1.3-0.5
Bone volume0.71.22.5-1.2-1.21.3-1.1-1.0-1.21.1-1.0-1.0-0.9-1.0-1.11.1-1.6-0.0
Breakpoint value in progressive ratio session1.11.23.60.10.50.20.91.01.2-1.10.90.91.61.40.8-1.11.5-1.9
Number of licking bursts4.55.36.6-2.4-2.52.1-2.4-2.5-2.62.5-2.3-2.3-2.5-2.4-2.02.1-2.40.5
Context. condit. distance diff. score0.10.10.20.40.30.10.20.10.3-0.20.20.20.30.20.1-0.1-0.10.4
Locomotion velocity, session 11.11.211.5-1.1-0.61.10.20.20.4-0.60.40.41.11.00.1-0.60.1-3.4
Locomotion distance, session 10.30.33.6-0.9-0.60.4-0.2-0.1-0.0-0.1-0.1-0.10.30.3-0.1-0.20.2-1.9
Locomotion velocity, session 22.93.45.1-1.5-1.91.5-2.0-2.3-1.81.9-2.1-2.1-1.7-1.9-2.12.1-1.30.6
Locomotion distance, session 21.11.54.2-2.0-1.60.7-1.3-1.4-1.41.1-1.2-1.2-1.2-1.0-0.70.6-0.4-1.4
Locomotion velocity, session 30.30.32.6-0.4-0.10.30.30.30.4-0.50.40.40.60.60.3-0.50.2-1.6
Locomotion distance, session 32.12.35.5-1.8-1.92.3-1.5-1.2-1.31.2-1.4-1.4-0.8-1.0-1.71.4-1.9-1.1
Stereotopy head waving bouts, day 30.91.02.50.10.7-0.41.00.50.8-1.01.11.10.91.21.4-1.50.9-1.6
Stereotopy head waving duration, day 30.91.12.20.61.0-0.71.10.70.9-1.01.11.10.91.21.5-1.51.0-0.9
Locomotion velocity, session 70.00.00.10.30.2-0.20.20.30.3-0.20.20.20.20.20.1-0.10.00.1
Locomotion distance, session 70.20.20.5-0.7-0.60.6-0.5-0.4-0.40.4-0.4-0.4-0.2-0.3-0.50.4-0.7-0.5
Stereotopy head waving bouts, day 71.92.14.6-1.7-1.72.1-1.5-1.4-1.41.4-1.4-1.4-1.0-1.1-1.41.3-1.7-0.7
Stereotopy head waving duration, day 70.30.30.8-0.9-0.80.8-0.5-0.6-0.70.5-0.5-0.5-0.5-0.4-0.30.2-0.5-0.7
Locomotion velocity, session 80.30.41.6-0.40.2-0.70.40.20.3-0.40.50.50.30.50.8-0.91.0-1.3
Locomotion distance, session 80.10.21.4-0.7-0.30.2-0.1-0.3-0.10.0-0.0-0.00.10.10.2-0.30.2-1.2
Degree of sensitization distance1.31.33.51.11.4-1.91.10.81.0-1.01.11.10.60.81.4-1.21.40.5
Degree of sensitization stereotypy1.51.63.5-1.2-1.41.9-1.3-1.1-1.21.1-1.2-1.2-0.9-1.0-1.41.3-1.6-0.2
Conditioned locomotion0.30.41.90.00.00.60.30.50.6-0.60.40.41.00.80.0-0.2-0.2-1.4
Cocaine response after cond. corrected2.83.14.31.11.5-1.11.81.91.9-2.02.02.02.02.11.7-1.91.2-1.9
Cocaine response after cond. not corrected2.93.24.60.91.4-1.31.81.91.7-1.92.02.01.82.02.0-2.21.6-2.1
Cocaine response before conditioning0.60.71.6-1.1-0.90.3-0.9-0.9-1.21.0-0.9-0.9-1.3-1.0-0.40.5-0.40.2
Saline control response0.40.62.4-1.4-0.91.0-0.5-0.4-0.70.4-0.2-0.2-0.4-0.2-0.0-0.1-0.9-1.6
Bone: connectivity density0.91.52.3-0.9-1.21.3-1.3-1.1-1.11.2-1.3-1.3-1.0-1.2-1.51.5-1.30.6
Bone: cortical apparent density0.30.43.50.50.1-0.4-0.3-0.2-0.40.4-0.3-0.3-0.7-0.6-0.40.6-0.51.9
Bone: cortical area2.63.94.7-1.8-2.01.5-2.1-2.0-2.22.1-2.0-2.0-2.1-2.2-1.92.0-2.10.9
Bone: cortical porosity0.40.50.80.80.9-0.50.80.60.8-0.70.70.70.70.70.7-0.70.90.1
Bone: cortical porosity0.00.00.10.10.10.30.1-0.00.1-0.0-0.0-0.00.20.1-0.0-0.00.1-0.1
Bone: cortical thickness1.42.43.9-0.9-1.31.2-1.5-1.3-1.51.6-1.5-1.5-1.5-1.7-1.71.9-2.01.5
Bone: cortical thickness0.10.10.60.30.2-0.50.10.4-0.0-0.10.20.2-0.2-0.0-0.00.2-0.40.8
Bone: cortical tissue density0.20.33.00.50.2-0.4-0.2-0.1-0.30.3-0.2-0.2-0.5-0.5-0.30.5-0.41.7
Condit. Reinf. active minus inactive responses0.50.60.9-0.7-0.80.3-0.9-0.8-0.80.9-0.9-0.9-0.9-0.9-0.80.8-0.20.4
Condit. Reinf. active-inactive response ratio0.40.50.80.90.8-0.90.70.90.6-0.60.70.70.40.50.6-0.50.60.5
Condit. Reinf. active responses2.83.44.7-1.9-2.01.2-2.0-2.2-2.02.1-2.1-2.1-2.0-2.1-1.81.8-1.00.6
Condit. Reinf. inactive responses3.54.27.0-1.9-2.11.3-2.2-2.6-2.32.4-2.3-2.3-2.4-2.3-1.71.9-1.20.8
Incentive salience index mean3.74.56.1-2.4-2.51.8-2.4-2.4-2.22.3-2.4-2.4-2.1-2.2-2.12.0-1.3-0.2
Condit. Reinf. lever presses8.010.716.6-4.1-4.03.3-3.6-3.7-3.43.5-3.6-3.6-2.9-3.1-3.12.8-2.3-1.2
Condit. Reinf. active minus inactive responses0.70.91.1-1.0-1.00.9-1.0-1.0-1.01.1-1.0-1.0-1.0-1.0-0.90.9-0.90.2
Condit. Reinf. active-inactive response ratio0.30.30.5-0.3-0.40.5-0.6-0.6-0.50.6-0.6-0.6-0.4-0.6-0.70.7-0.70.6
Condit. Reinf. active responses2.12.94.0-2.0-1.91.6-1.8-1.8-1.91.9-1.8-1.8-1.8-1.8-1.51.5-1.30.0
Condit. Reinf. inactive responses2.93.64.9-2.0-2.01.4-2.1-2.0-2.22.1-2.1-2.1-2.2-2.1-1.71.7-1.20.6
Condit. Reinf. lever presses2.83.85.1-1.7-1.91.2-2.1-2.3-2.22.2-2.2-2.2-2.3-2.2-1.81.9-1.21.2
Condit. Reinf. lever reinforcers received2.43.44.7-2.2-2.11.6-2.0-2.0-2.12.0-2.0-2.0-1.9-1.9-1.71.7-1.20.0
Conditioned reinforcement - actives0.40.41.2-0.3-0.41.1-0.7-0.7-0.30.5-0.8-0.80.0-0.5-1.00.9-0.60.2
Conditioned reinforcement - inactives0.10.10.40.30.10.30.20.10.4-0.3-0.0-0.00.60.3-0.1-0.0-0.2-0.3
Conditioned locomotion0.60.72.0-0.5-0.91.4-0.9-0.9-0.40.6-0.9-0.90.0-0.5-1.41.2-0.9-0.2
Patch foraging indifference point 0 sec0.71.27.6-1.0-0.82.3-0.10.10.4-0.3-0.1-0.11.30.7-0.6-0.2-0.5-2.8
Patch foraging indifference point AUC7.28.212.1-3.5-3.33.0-3.2-3.2-3.03.0-3.0-3.0-2.5-2.8-2.72.7-2.3-0.6
Delay disc. indifference point, 0s delay1.71.82.21.11.3-1.11.41.41.5-1.51.41.41.51.51.4-1.51.4-0.8
Delay disc. indifference point, 16s delay1.91.93.40.71.0-0.61.41.81.6-1.61.11.11.81.71.2-1.31.3-1.5
Delay disc. indifference point, 2s delay0.10.10.30.0-0.10.1-0.3-0.4-0.30.3-0.4-0.4-0.3-0.4-0.20.4-0.50.6
Delay disc. indifference point, 24s delay0.20.20.60.40.4-0.80.40.40.3-0.40.30.30.20.30.6-0.40.60.0
Delay disc. indifference point, 4s delay0.10.10.20.30.2-0.40.20.30.3-0.30.10.10.30.30.2-0.10.5-0.1
Delay disc. indifference point, 8s delay0.10.10.4-0.1-0.1-0.2-0.10.1-0.00.1-0.5-0.50.0-0.1-0.0-0.00.7-0.2
Indifference point function ln k2.53.54.52.12.0-1.82.12.12.0-2.02.02.01.71.91.8-1.91.50.0
Indifference point function log k2.53.54.52.12.0-1.82.12.12.0-2.02.02.01.71.91.8-1.91.50.0
Patch foraging total patch changes 0 sec0.81.46.6-1.3-1.22.6-0.5-0.3-0.00.1-0.5-0.50.90.3-1.00.3-1.0-2.6
Patch foraging total patch changes 12 sec2.63.47.4-1.8-2.02.7-1.9-1.7-1.71.8-1.9-1.9-1.1-1.6-2.11.9-2.3-0.2
Patch foraging total patch changes 18 sec0.60.71.7-1.3-1.11.2-0.9-0.9-0.80.8-0.9-0.9-0.5-0.6-0.80.5-0.4-0.7
Patch foraging total patch changes 24 sec2.42.97.0-2.1-2.02.6-1.7-1.7-1.41.5-1.7-1.7-0.7-1.3-1.91.6-1.8-1.1
Patch foraging total patch changes 6 sec2.43.610.9-2.4-2.43.3-1.8-1.7-1.41.5-1.8-1.8-0.5-1.1-2.21.6-1.7-1.9
Patch foraging time to switch 0 sec2.43.86.72.52.3-2.62.11.91.9-1.81.81.81.11.52.0-1.82.11.2
Patch foraging water rate 0 sec1.93.08.7-2.0-2.13.0-1.7-1.2-1.31.2-1.4-1.4-0.4-0.9-2.01.7-2.7-1.5
Patch foraging water rate 12 sec0.10.10.5-0.3-0.10.40.00.0-0.1-0.20.30.30.20.30.2-0.3-0.6-0.7
Patch foraging water rate 18 sec0.71.03.4-0.5-0.91.3-1.0-0.6-0.80.8-0.9-0.9-0.5-0.8-1.21.2-1.90.5
Patch foraging water rate 24 sec0.40.51.80.2-0.20.2-0.6-0.4-0.60.5-0.5-0.5-0.4-0.6-1.01.0-1.31.3
Patch foraging water rate 6 sec0.50.72.9-1.0-1.10.8-0.9-0.6-0.90.8-0.6-0.6-0.8-0.7-0.70.7-1.7-0.2
Seeking ratio, delayed vs. immediate footshock4.24.97.6-1.7-2.62.3-2.3-2.2-2.12.3-2.8-2.8-1.8-2.1-2.82.5-1.00.4
Distance traveled before self-admin3.03.26.8-2.6-2.42.2-1.8-1.6-1.81.7-1.8-1.8-1.5-1.4-1.51.2-1.8-1.1
Distance traveled after self-admin0.60.72.1-0.7-0.9-0.1-0.8-1.0-1.01.0-0.9-0.9-1.5-1.0-0.60.7-0.00.6
Extensor digitorum longus weight4.216.422.5-4.7-4.74.5-4.4-4.3-4.24.2-4.3-4.3-3.6-3.9-4.03.8-3.6-0.5
Bone: elastic displacement2.83.16.72.62.3-1.61.92.11.9-1.81.81.81.71.61.4-1.21.21.3
Bone: elastic work0.91.17.21.91.3-1.10.70.90.7-0.50.50.50.30.20.20.10.32.7
Bone: endosteal estimation0.51.23.1-1.8-1.40.9-1.1-1.3-1.21.1-1.0-1.0-1.0-0.9-0.60.5-0.9-1.1
Bone: endosteal perimeter0.61.23.3-1.8-1.41.0-1.1-1.2-1.11.0-0.9-0.9-0.8-0.8-0.70.5-0.8-1.5
Epididymis fat weight0.20.51.3-1.1-0.90.4-0.8-0.9-1.10.8-0.2-0.2-0.9-0.7-0.30.3-0.4-0.5
Delta time in closed arm before/after self-admin3.33.25.0-1.4-1.71.0-2.0-2.2-2.02.1-1.9-1.9-2.2-2.1-1.71.8-1.01.2
Delta time in open arm before/after self-admin0.90.82.00.60.7-0.60.91.00.9-1.00.60.61.21.00.9-1.01.4-0.8
Diff in mean of infusions in LGA sessions0.10.10.40.30.2-0.50.1-0.1-0.0-0.00.20.2-0.1-0.0-0.0-0.10.60.3
Delay discount exponential model param0.60.61.7-0.4-0.60.5-0.7-0.9-0.90.8-0.4-0.4-1.0-0.9-0.70.7-1.30.8
Extinction: sum of active levers before priming2.22.26.71.51.5-1.51.51.41.4-1.41.31.31.21.41.3-1.52.6-0.2
Active lever presses in extinction session 60.50.42.20.60.60.10.50.50.7-0.70.30.31.10.70.1-0.41.5-0.6
Bone: final force1.01.62.7-1.6-1.40.6-1.3-1.4-1.61.4-1.3-1.3-1.7-1.4-1.01.0-0.90.1
Bone: final moment0.81.32.5-1.3-1.20.3-1.2-1.2-1.51.3-1.1-1.1-1.6-1.3-0.80.9-0.80.4
Food consumed during 24 hour testing period0.50.61.5-1.2-1.00.6-0.8-0.7-0.90.8-0.8-0.8-0.9-0.7-0.60.6-0.6-0.6
Glucose1.01.52.2-1.5-1.41.5-1.3-1.3-1.31.3-1.0-1.0-1.1-1.1-1.21.2-1.2-0.4
Heart weight0.40.61.3-1.1-1.10.7-0.9-0.6-0.90.8-0.9-0.9-0.7-0.7-0.70.7-0.3-0.6
Delay discount hyperbolic model param0.50.51.4-0.4-0.50.5-0.7-0.8-0.80.8-0.3-0.3-1.0-0.8-0.60.6-1.20.8
Intermittent access intake day 1-15 change1.31.22.4-0.4-0.90.3-1.1-1.0-1.21.2-0.9-0.9-1.6-1.4-1.01.3-1.51.3
Intermittent access intake escalation1.81.73.5-0.8-1.20.7-1.3-1.3-1.41.4-1.0-1.0-1.7-1.6-1.31.5-1.91.1
Intermittent access intake escalation 22.52.55.6-0.6-1.30.7-1.5-1.5-1.71.6-1.4-1.4-1.9-1.8-1.61.9-2.41.7
Intermitt. access day 1 inactive lever presses0.80.81.3-0.9-1.11.1-0.9-0.8-0.90.8-0.9-0.9-0.6-0.8-1.01.0-1.2-0.1
Intermitt. access day 15 inactive lever presses0.10.10.5-0.1-0.30.60.20.10.3-0.20.00.00.30.40.1-0.1-0.1-0.7
Intermitt. access escalation Index0.70.62.1-1.4-0.90.9-0.5-0.7-0.70.6-0.2-0.2-0.7-0.5-0.10.1-1.5-0.9
Intermittent access day 1 total infusions0.70.83.50.40.50.70.70.81.2-1.00.40.41.91.10.1-0.40.9-1.3
Intermittent access day 15 total infusions0.70.82.0-0.6-0.91.4-0.9-0.8-0.60.7-0.9-0.9-0.2-0.7-1.31.2-1.0-0.1
Intermittent access terminal intake (last 3 days)1.01.12.9-0.7-1.11.7-1.0-0.8-0.70.8-1.0-1.0-0.2-0.8-1.51.4-1.4-0.2
Intermittent access total infusions1.01.14.0-0.9-1.12.0-1.0-0.9-0.60.7-1.1-1.10.1-0.6-1.61.4-1.0-0.6
Intermittent access day 1 locomotion0.90.93.90.70.70.30.71.01.4-1.10.40.42.01.1-0.1-0.31.2-1.1
Intermittent access day 15 total locomotion0.50.52.21.00.50.40.60.71.1-0.90.30.31.50.8-0.20.10.6-0.3
Intermittent access total locomotion0.30.31.20.90.30.50.20.40.8-0.5-0.1-0.11.10.3-0.80.60.20.2
Intermittent access standard deviation0.50.50.9-0.3-0.70.8-0.7-0.7-0.80.7-0.9-0.9-0.7-0.7-0.71.0-0.40.6
Left kidney weight0.30.82.0-1.4-1.31.3-0.8-0.6-0.80.7-0.8-0.8-0.4-0.5-0.80.6-0.7-1.3
Right kidney weight0.10.20.9-0.3-0.3-0.50.10.20.1-0.2-0.2-0.20.10.20.0-0.20.9-1.0
Cocaine induced anxiety1.41.63.01.21.4-1.21.31.21.2-1.31.71.71.11.31.5-1.20.2-0.2
Post-drug Anxiety0.20.20.6-0.8-0.2-0.4-0.1-0.3-0.50.30.30.3-0.7-0.30.6-0.4-0.6-0.3
Baseline Anxiety1.81.93.1-1.3-1.30.5-1.5-1.3-1.71.6-1.7-1.7-1.8-1.7-1.41.2-0.20.7
Tail length1.85.611.6-3.4-3.01.8-2.6-2.6-2.82.5-2.2-2.2-2.5-2.2-2.21.8-1.5-1.0
Length with tail0.41.64.6-2.1-1.71.3-1.2-1.3-1.41.3-1.1-1.1-1.1-1.0-0.70.5-0.7-1.4
Length without tail0.41.01.61.11.1-0.41.11.11.2-1.10.90.91.31.11.1-1.00.6-0.4
Times rat made contact with spout0.60.71.9-0.5-0.71.0-0.7-0.6-0.70.8-0.7-0.7-0.8-0.8-0.80.9-1.40.8
Lifetime Intake0.91.04.3-1.0-1.12.1-0.8-0.5-0.20.4-0.8-0.80.6-0.2-1.41.0-0.7-1.4
Liver weight, left0.30.41.7-1.0-0.4-0.5-0.4-0.7-1.10.7-0.0-0.0-1.3-0.60.5-0.20.3-0.0
Liver weight, right0.30.41.20.10.6-0.60.70.50.3-0.50.70.70.20.51.1-1.10.9-0.4
Locomotor activity0.00.00.3-0.1-0.2-0.1-0.10.1-0.10.1-0.2-0.2-0.2-0.1-0.00.10.5-0.0
Locomotor testing distance0.20.41.4-0.10.2-0.40.50.60.5-0.60.50.50.50.70.9-0.80.8-1.2
Locomotor testing rearing0.30.41.5-1.2-0.90.4-0.6-0.6-0.80.7-0.6-0.6-0.8-0.5-0.20.1-0.2-0.8
Locomotion in novel chamber0.20.30.80.20.0-0.0-0.4-0.3-0.20.4-0.8-0.8-0.3-0.6-0.60.6-0.10.9
Locomotion in novel chamber post-restriction2.53.04.8-1.2-1.30.7-1.9-1.8-2.02.0-1.8-1.8-2.1-2.2-1.81.8-1.71.7
Fecal boli incidents, locomotor time 10.50.51.51.10.9-1.00.70.60.7-0.60.40.40.50.50.4-0.41.20.6
Change in fecal boli incidents, locomotor task0.80.83.3-1.4-1.01.5-0.7-0.6-0.60.5-0.3-0.3-0.1-0.3-0.70.3-1.8-1.1
Time >=10cm from walls, locomotor time 10.30.31.1-0.30.10.50.30.60.3-0.40.60.60.60.50.4-0.5-0.4-1.0
Bouts of movement, locomotor time 11.61.72.61.61.6-1.61.41.21.4-1.41.11.11.21.21.2-1.41.50.3
Total resting periods, locomotor time 11.71.93.61.91.8-1.91.51.21.4-1.31.11.11.01.11.3-1.31.50.8
Rest time, locomotor task time 11.11.25.91.81.3-2.10.60.10.4-0.30.40.4-0.4-0.10.5-0.40.72.4
Distance moved, locomotor task time 11.21.34.0-1.9-1.52.0-1.0-0.4-0.80.7-0.8-0.8-0.2-0.4-0.80.7-1.3-1.9
Vertical activity count, locomotor time 10.70.75.2-1.6-0.81.3-0.20.3-0.30.10.00.00.20.20.3-0.4-0.7-2.3
Time >=10cm from walls, locomotor time 20.10.10.1-0.4-0.30.1-0.1-0.3-0.20.2-0.2-0.2-0.3-0.10.1-0.10.3-0.3
Bouts of movement, locomotor time 20.50.61.0-0.8-1.00.8-0.8-0.9-0.70.8-0.8-0.8-0.6-0.7-1.00.80.0-0.1
Total resting periods, locomotor time 20.30.30.7-0.5-0.70.6-0.6-0.6-0.40.5-0.6-0.6-0.3-0.5-0.90.70.20.1
Rest time, locomotor task time 20.60.71.31.11.1-0.90.80.90.9-0.80.90.90.70.70.7-0.70.00.6
Distance moved, locomotor task time 20.50.61.8-0.5-0.7-0.2-0.7-0.8-1.00.9-0.9-0.9-1.3-1.0-0.40.6-0.30.7
Vertical activity count, locomotor time 20.20.30.8-0.9-0.70.0-0.4-0.4-0.70.6-0.4-0.4-0.9-0.50.1-0.10.1-0.4
Light reinforcement 10.61.19.3-1.8-1.00.8-0.0-0.0-0.3-0.10.20.2-0.10.50.6-0.90.0-3.1
Light reinforcement 21.21.611.5-1.2-0.10.40.70.60.5-0.90.90.91.11.21.2-1.60.4-3.4
Bone: marrow area0.61.43.2-1.8-1.41.0-1.2-1.4-1.31.2-1.1-1.1-1.2-1.1-0.80.7-1.0-0.9
Bone: maximum diameter1.93.64.9-2.1-2.11.5-2.0-2.2-2.12.1-2.0-2.0-2.1-2.0-1.61.6-1.70.1
Bone: maximum force2.64.46.2-2.4-2.31.3-2.3-2.3-2.52.3-2.3-2.3-2.5-2.3-1.91.9-1.50.3
Bone: maximum moment2.13.65.4-2.1-2.01.0-2.1-2.1-2.22.1-2.0-2.0-2.3-2.1-1.71.7-1.30.5
Mean time between licks in bursts0.81.14.40.71.1-2.10.90.80.6-0.70.90.90.10.61.4-1.21.60.3
Mean num. licks in bursts1.82.23.21.81.7-1.41.61.71.7-1.61.51.51.61.51.2-1.21.30.2
Cd content in liver1.11.22.1-0.9-0.90.3-1.1-1.1-1.31.2-1.2-1.2-1.4-1.3-0.91.0-1.00.8
Co content in liver1.82.13.71.01.5-1.21.61.51.4-1.51.71.71.31.51.9-1.80.4-0.7
Cu content in liver0.91.13.31.31.4-1.81.00.90.6-0.81.21.20.10.61.3-0.90.51.0
Fe content in liver0.60.74.1-0.70.0-0.30.60.50.5-0.61.01.00.60.81.0-1.00.5-2.0
K content in liver0.50.50.90.30.5-0.50.80.80.8-0.80.70.70.80.80.9-1.00.4-0.8
Mg content in liver0.60.61.10.70.9-0.30.80.71.0-0.80.70.71.00.80.8-0.90.6-0.4
Mn content in liver0.30.40.7-0.2-0.40.1-0.6-0.8-0.60.7-0.7-0.7-0.8-0.8-0.50.7-0.30.9
Na content in liver2.22.35.51.31.6-2.31.61.41.1-1.31.91.90.61.22.0-1.71.40.1
Rb content in liver4.05.07.72.32.5-2.12.52.82.4-2.42.22.22.22.32.4-2.41.4-0.4
Se content in liver1.82.24.3-1.3-1.50.2-1.6-2.1-1.71.7-1.5-1.5-2.0-1.8-1.31.5-0.00.8
Sr content in liver0.40.41.2-0.7-0.60.2-0.7-1.1-0.60.8-0.5-0.5-0.6-0.7-0.40.50.60.1
Zn content in liver0.40.50.9-0.1-0.40.0-0.7-0.5-0.50.7-0.9-0.9-0.7-0.8-0.80.9-0.60.9
Bone: minimum diameter0.00.00.20.20.1-0.2-0.1-0.10.00.1-0.1-0.1-0.0-0.2-0.20.2-0.00.5
Time in familiar zone, hab. session 10.80.86.30.90.2-0.0-0.4-0.3-0.30.5-0.4-0.4-0.5-0.7-0.81.1-0.82.5
Time in novel zone, hab. session 14.64.57.40.81.7-1.92.21.91.9-2.12.12.11.82.32.6-2.72.6-2.3
Total zone transitions, hab. session 10.00.00.1-0.1-0.1-0.3-0.2-0.3-0.10.1-0.2-0.2-0.2-0.2-0.10.10.30.1
Total locomotion distance, hab. session 10.81.12.1-0.5-0.70.0-1.1-1.3-1.11.2-1.2-1.2-1.4-1.3-1.01.1-0.21.5
Locomotion velocity, hab. session 12.02.94.2-1.3-1.60.8-1.8-2.1-1.91.9-1.9-1.9-2.0-2.0-1.61.7-0.81.2
Time in familiar zone, hab. session 20.50.53.01.10.8-1.10.40.30.3-0.20.30.3-0.1-0.00.4-0.20.61.7
Time in novel zone, hab. session 22.32.33.50.81.2-0.71.61.61.6-1.71.61.61.91.81.4-1.61.0-1.8
Total zone transitions, hab. session 20.30.41.1-1.1-0.90.4-0.6-0.7-0.50.5-0.6-0.6-0.4-0.4-0.50.3-0.2-1.0
Total locomotion distance, hab. session 20.81.01.5-1.1-1.20.7-1.2-1.2-1.11.1-1.2-1.2-1.0-1.0-1.11.0-0.50.0
Locomotion velocity, hab. session 21.11.52.1-1.2-1.40.9-1.4-1.4-1.31.3-1.4-1.4-1.2-1.2-1.31.2-0.70.1
Novel to familiar place preference ratio4.54.66.01.72.1-1.42.32.42.4-2.42.32.32.52.42.2-2.31.9-1.4
Novelty place preference5.65.77.22.12.4-1.62.62.72.7-2.62.62.62.72.62.3-2.42.0-1.2
Time in novel zone, NPP test6.97.18.82.32.7-2.02.93.02.9-2.92.92.92.92.92.7-2.82.3-1.3
Total zone transitions, NPP test0.30.51.8-1.3-1.00.4-0.6-0.6-0.60.5-0.6-0.6-0.5-0.3-0.40.2-0.1-1.3
Total locomotion distance, NPP test1.31.83.4-1.9-1.71.6-1.4-1.5-1.21.2-1.4-1.4-0.9-1.0-1.31.0-1.0-1.2
Locomotion velocity, NPP test2.02.84.3-2.1-2.11.9-1.8-1.8-1.61.6-1.8-1.8-1.2-1.4-1.71.5-1.4-0.9
Intraocular pressure1.92.65.9-2.1-1.92.4-1.6-1.6-1.41.4-1.5-1.5-0.9-1.2-1.41.2-2.2-1.1
Delta distance traveled before/after self-admin0.70.72.51.01.0-1.60.90.50.7-0.70.70.70.10.51.0-0.91.00.5
Delta ambulatory time before/after self-admin1.71.84.81.71.6-2.21.40.91.1-1.21.21.20.41.01.5-1.31.70.7
Parametrial fat weight0.10.20.5-0.7-0.60.2-0.4-0.3-0.50.3-0.5-0.5-0.5-0.1-0.10.0-0.4-0.6
Pavlov. Cond. lever latency6.17.711.73.43.3-2.73.03.03.0-2.92.92.92.72.72.6-2.52.10.7
Pavlov. Cond. magazine entry latency0.40.50.9-0.7-0.70.1-0.8-0.9-0.80.8-0.8-0.8-1.0-0.8-0.60.60.00.2
Pavlov. Cond. change in total contacts2.22.33.5-1.9-1.91.5-1.6-1.6-1.61.6-1.6-1.6-1.5-1.5-1.51.4-1.2-0.4
Pavlov. Cond. index score2.83.64.9-2.2-2.11.3-2.1-2.2-2.12.1-2.1-2.1-2.1-2.1-1.71.7-1.00.1
Pavlov. Cond. latency score2.63.34.4-2.1-2.11.3-2.0-2.1-2.02.0-2.0-2.0-2.0-2.0-1.81.7-1.0-0.0
Pavlov. Cond. lever contacts4.95.88.1-2.7-2.82.4-2.6-2.6-2.52.5-2.6-2.6-2.2-2.4-2.52.3-1.9-0.4
Pavlov. Cond. magazine entry number0.70.91.51.01.1-0.41.11.11.1-1.11.11.11.21.10.9-0.90.4-0.2
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.5-0.50.2-0.5-0.6-0.50.6-0.6-0.6-0.5-0.6-0.40.4-0.20.2
Pavlov. Cond. lever-magazine prob. diff.2.93.55.0-2.0-2.11.2-2.1-2.2-2.12.1-2.1-2.1-2.1-2.1-1.81.8-1.00.4
Pavlov. Cond. response bias2.83.44.7-2.1-2.21.5-2.1-2.1-2.02.0-2.0-2.0-1.9-1.9-1.81.8-1.2-0.1
Pavlov. Cond. lever latency3.14.15.81.81.9-1.32.22.42.3-2.42.22.22.42.31.8-1.91.4-1.3
Pavlov. Cond. magazine entry latency0.50.62.30.70.9-1.50.70.40.4-0.50.60.60.00.41.0-0.81.30.6
Pavlov. Cond. change in total contacts1.31.84.0-0.7-0.9-0.0-1.3-1.6-1.61.6-1.3-1.3-2.0-1.7-0.91.2-0.72.0
Pavlov. Cond. index score0.50.61.8-0.3-0.4-0.4-0.6-0.9-0.90.9-0.7-0.7-1.2-1.0-0.40.6-0.11.3
Pavlov. Cond. latency score0.70.92.2-0.4-0.6-0.1-0.9-1.1-1.11.1-1.0-1.0-1.3-1.2-0.70.9-0.41.5
Pavlov. Cond. lever contacts1.52.03.2-1.3-1.30.9-1.5-1.8-1.61.7-1.6-1.6-1.7-1.7-1.21.3-0.80.8
Pavlov. Cond. magazine entry number0.40.52.7-0.10.00.70.40.60.7-0.60.50.51.00.80.2-0.4-0.1-1.6
Pavlov. Cond. intertrial magazine entries0.50.61.5-0.8-0.91.2-0.8-0.6-0.60.7-0.8-0.8-0.3-0.6-0.90.8-1.1-0.4
Pavlov. Cond. lever-magazine prob. diff.0.50.62.1-0.3-0.3-0.4-0.6-0.9-0.90.9-0.7-0.7-1.3-1.0-0.30.6-0.11.4
Pavlov. Cond. response bias0.70.91.9-0.8-0.70.1-1.0-1.3-1.21.2-1.0-1.0-1.4-1.2-0.60.8-0.21.0
Time in closed arm before self-admin1.92.23.31.81.7-1.01.51.81.6-1.71.71.71.81.61.0-0.90.80.1
Time in closed arm after self-admin0.10.10.60.50.3-0.2-0.0-0.10.0-0.00.20.2-0.2-0.10.00.2-0.50.8
Time in open arm before self-admin1.41.54.0-2.0-1.61.6-1.2-1.2-1.21.2-1.1-1.1-0.9-0.9-1.00.5-0.8-1.1
Time in open arm after self-admin0.80.92.6-1.4-1.31.6-0.8-0.7-0.70.7-1.1-1.1-0.1-0.5-1.00.6-0.1-1.2
Bone: periosteal estimation1.22.44.0-2.0-1.81.2-1.6-1.7-1.81.7-1.5-1.5-1.7-1.6-1.21.2-1.6-0.3
Bone: periosteal perimeter0.30.51.3-1.2-0.90.7-0.6-0.7-0.70.6-0.5-0.5-0.5-0.4-0.40.3-0.6-1.0
Bone: post-yield work0.81.02.7-1.6-1.30.6-1.1-1.3-1.11.0-1.0-1.0-1.0-0.9-0.60.5-0.3-1.0
Progressive ratio test 1 active lever presses0.70.74.0-0.4-0.62.0-0.30.20.4-0.1-0.3-0.31.10.3-1.00.7-0.8-1.4
Progressive ratio test 1 breakpoint0.70.74.2-0.6-0.82.0-0.40.00.20.0-0.4-0.40.90.1-1.10.8-1.0-1.4
Progressive ratio test 1 inactive lever presses0.60.74.6-0.9-0.81.4-0.10.30.4-0.30.00.00.90.5-0.30.1-0.9-2.2
Progressive ratio test 2 active lever presses0.40.52.3-0.1-0.01.10.30.40.7-0.60.10.11.40.7-0.2-0.1-0.1-1.5
Progressive ratio test 2 breakpoint0.50.62.40.20.11.00.50.70.9-0.80.30.31.50.9-0.1-0.20.2-1.5
Progressive ratio test 2 inactive lever presses0.30.30.9-0.4-0.61.0-0.5-0.3-0.10.2-0.5-0.50.3-0.2-0.70.7-0.8-0.5
Incentive Sensitization - Responses0.20.20.50.10.00.30.40.40.4-0.40.40.40.60.50.1-0.3-0.2-0.7
Incentive Sensitization - Breakpoint0.20.20.50.20.20.20.50.50.5-0.50.50.50.70.60.2-0.4-0.1-0.7
Sum of active levers in priming session hrs 5-63.63.55.51.71.9-1.12.02.02.2-2.11.71.72.42.11.6-1.82.2-1.0
Progressive ratio0.00.00.40.10.0-0.20.10.10.2-0.20.00.00.20.2-0.0-0.00.6-0.3
Food seeking constrained by brief footshock5.26.414.7-3.5-3.13.8-2.6-2.4-2.32.3-2.5-2.5-1.3-1.8-2.42.0-2.3-1.9
Seeking ratio, punishment vs. effort1.41.73.9-1.8-1.52.0-1.4-1.3-1.31.3-1.1-1.1-0.9-1.1-1.11.0-1.8-0.6
Retroperitoneal fat weight0.10.30.80.80.4-0.90.40.20.4-0.30.40.40.00.30.3-0.20.90.6
Reaction time number correct0.10.10.6-0.6-0.30.6-0.20.2-0.20.0-0.1-0.10.2-0.0-0.20.2-0.2-0.8
Reaction time mean minus median1.62.16.6-0.3-0.7-0.2-1.2-1.7-1.51.6-1.5-1.5-2.0-1.9-1.11.4-0.22.6
Reaction time mean minus median AUC1.92.54.1-0.9-1.10.4-1.6-2.0-1.81.8-1.8-1.8-2.0-2.0-1.31.5-0.51.9
Reaction time num false alarms0.20.20.60.0-0.3-0.2-0.4-0.2-0.30.4-0.6-0.6-0.4-0.6-0.70.60.50.8
Reaction time num false alarms AUC0.40.61.2-0.6-0.90.5-0.8-0.5-0.60.8-1.0-1.0-0.6-0.8-1.11.00.10.2
Reaction time trials correct on left0.10.10.6-0.6-0.30.6-0.20.2-0.20.0-0.1-0.10.2-0.0-0.20.2-0.2-0.8
Reaction time trials on left0.10.10.5-0.5-0.20.5-0.10.3-0.1-0.0-0.0-0.00.30.1-0.20.1-0.1-0.7
Reaction time mean0.81.25.11.51.3-2.10.80.40.4-0.40.70.7-0.40.10.8-0.51.02.2
Reaction time mean AUC0.91.35.41.71.4-2.20.80.50.5-0.50.70.7-0.20.10.8-0.51.02.3
Median of all reaction times2.02.77.32.12.0-2.71.61.41.3-1.41.71.70.61.11.6-1.41.51.6
Reaction time omissions1.31.83.41.61.5-1.81.41.11.3-1.21.21.20.81.21.5-1.31.80.6
Reaction time false alarm rate0.10.10.50.3-0.1-0.3-0.2-0.10.00.2-0.4-0.4-0.2-0.3-0.40.40.60.7
Reaction time premature initiation rate1.41.96.02.41.6-1.11.61.41.6-1.31.41.41.01.11.2-0.80.11.2
Reaction time premature initiations0.91.23.61.91.3-0.61.31.31.3-1.11.21.21.01.00.9-0.6-0.10.7
Std. dev. reaction times0.71.06.60.60.2-1.2-0.4-0.9-0.70.7-0.6-0.6-1.4-1.0-0.20.50.52.6
Reaction time trials completed0.10.10.5-0.5-0.20.5-0.10.3-0.1-0.0-0.0-0.00.30.1-0.20.1-0.1-0.7
Reaction time trials AUC0.10.10.4-0.5-0.20.5-0.10.3-0.1-0.0-0.0-0.00.20.1-0.20.1-0.2-0.7
Run reversals in cocaine runway, females0.30.30.8-0.2-0.1-0.3-0.5-0.2-0.70.6-0.1-0.1-0.8-0.8-0.40.6-0.60.9
Run reversals in cocaine runway, males0.00.00.10.40.00.3-0.0-0.10.1-0.00.00.00.1-0.0-0.40.30.40.2
Latency to leave start box in cocaine runway0.91.02.3-0.8-1.00.9-1.0-0.9-1.01.0-0.8-0.8-1.0-1.0-1.11.1-1.50.4
Latency to leave start box in cocaine runway, F0.00.00.10.0-0.10.20.00.10.1-0.10.10.10.10.1-0.10.1-0.2-0.2
Latency to leave start box in cocaine runway, M1.00.92.1-1.3-1.31.2-0.9-0.8-1.00.9-0.7-0.7-0.8-0.8-0.80.7-1.4-0.5
Std. dev. time between licks in bursts0.40.41.30.70.7-1.10.60.60.6-0.60.60.60.40.50.5-0.51.00.2
Total sessions with >9 infusions0.70.84.2-0.2-0.11.00.40.61.0-0.80.40.41.61.0-0.1-0.20.6-2.1
Short access day 1 total inactive lever presses2.02.26.0-1.6-1.92.4-1.3-0.9-0.91.0-1.1-1.1-0.4-0.9-1.81.6-2.5-1.1
Short access day 10 total inactive lever presses0.30.32.1-0.4-0.50.2-0.3-0.5-0.70.5-0.2-0.2-0.7-0.4-0.00.3-1.50.1
Short access day 1 total infusions1.01.04.7-1.3-1.31.9-0.5-0.30.10.2-0.5-0.50.70.1-1.10.6-0.8-2.2
Short access day 10 total infusions0.60.73.0-0.9-0.91.7-0.4-0.20.10.0-0.4-0.40.80.1-1.00.5-0.8-1.7
Short access total infusions0.60.74.5-0.6-0.61.40.00.30.6-0.4-0.0-0.01.30.6-0.60.1-0.1-2.1
Short access day 1 locomotion0.40.41.40.2-0.00.30.40.61.0-0.70.20.21.10.7-0.3-0.00.7-1.2
Short access day 10 total locomotion0.30.31.11.00.7-0.60.30.20.6-0.50.30.30.60.3-0.20.21.00.7
Short access total locomotion0.20.21.3-0.3-0.40.6-0.10.10.3-0.2-0.0-0.00.70.3-0.60.3-0.0-1.1
One hour access (0.3 mA shock)0.50.62.9-1.0-0.61.7-0.7-0.5-0.30.4-0.7-0.70.5-0.3-0.80.6-0.3-1.0
Compulsive drug intake0.20.30.6-0.8-0.30.7-0.6-0.4-0.40.5-0.7-0.7-0.3-0.5-0.30.20.3-0.2
One hour access (shock baseline)0.50.63.0-0.6-0.81.7-0.4-0.4-0.10.1-0.5-0.50.70.1-0.90.7-0.7-1.2
Social response proportion2.22.47.51.71.8-2.71.51.21.1-1.21.41.40.40.91.8-1.51.81.1
Social responses0.50.61.2-0.9-0.90.2-0.9-0.9-0.90.9-0.9-0.9-1.1-0.9-0.50.6-0.20.1
Social time0.70.93.60.20.7-1.80.70.50.3-0.50.70.7-0.30.41.4-1.31.9-0.1
Soleus weight0.72.07.7-0.50.5-0.81.21.01.0-1.31.31.31.11.51.7-2.01.5-2.8
Bone: stiffness3.25.08.2-2.7-2.51.0-2.4-2.6-2.72.6-2.4-2.4-2.9-2.5-1.71.8-1.30.2
Tibialis anterior weight5.418.432.0-5.7-5.24.7-4.6-4.5-4.64.4-4.3-4.3-3.9-3.9-3.93.7-4.1-1.5
Time to tail flick, vehicle, before self-admin0.70.81.71.31.1-0.60.90.90.9-1.01.01.01.10.90.4-0.40.70.3
Time to tail flick, vehicle, after self-admin0.00.00.20.1-0.10.40.10.20.3-0.10.10.10.20.2-0.00.2-0.4-0.3
Time to tail flick, test, before self-admin0.50.51.6-0.5-0.50.7-0.7-0.5-0.60.7-0.5-0.5-0.4-0.7-0.80.8-1.30.5
Time to tail flick, test, after self-admin1.51.52.7-0.6-0.91.1-1.3-1.3-1.31.2-1.1-1.1-1.0-1.3-1.41.6-1.61.0
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.5-0.40.1-0.2-0.4-0.20.4-0.1-0.1-0.5-0.40.10.1-0.3-0.1
Delta time to tail flick, test, before/after SA0.00.00.10.40.0-0.00.0-0.10.0-0.1-0.1-0.1-0.00.0-0.20.30.00.3
Tibia length0.30.93.3-0.50.3-1.10.80.90.4-0.81.11.10.30.81.3-1.30.7-1.8
Ambulatory time before self-admin2.32.45.3-2.3-2.22.2-1.5-1.1-1.41.3-1.6-1.6-0.9-1.0-1.31.1-1.3-1.4
Ambulatory time after self-admin0.10.20.5-0.5-0.50.0-0.3-0.4-0.20.3-0.6-0.6-0.5-0.2-0.20.10.7-0.2
Bone: tissue strength0.30.31.1-0.4-0.1-1.0-0.2-0.5-0.50.4-0.2-0.2-1.0-0.50.4-0.20.90.4
Total heroin consumption0.91.11.80.50.50.01.11.11.3-1.11.01.01.31.30.9-1.01.2-1.3
Bone: trabecular number1.52.32.8-1.3-1.61.2-1.7-1.6-1.61.7-1.6-1.6-1.5-1.7-1.61.7-1.50.7
Bone: trabecular spacing0.10.10.80.2-0.0-0.0-0.2-0.1-0.20.2-0.2-0.2-0.4-0.3-0.20.3-0.50.9
Bone: trabecular thickness0.10.10.30.40.4-0.30.30.00.3-0.20.10.10.30.20.2-0.20.50.2
Bone: trabecular tissue density1.72.34.6-2.1-1.70.6-1.6-2.0-2.01.7-1.6-1.6-2.1-1.6-0.80.9-0.5-0.2
Water consumed over 24 hours0.91.12.5-1.0-1.11.3-1.1-0.9-1.01.0-1.0-1.0-0.9-1.0-1.11.1-1.60.2
Number of responses in last shaping day0.80.85.9-0.6-0.40.70.50.60.9-0.70.50.50.91.00.6-0.80.1-2.4