Hub : Genes

Tesk1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Tesk1 0.06 0.04 9.1e-06 0.05 0.05 0.05 0.05 3.0e-06 5.3e-06 2.4e-06 1.8e-06
2 Brain mRNA stability Tesk1 0.08 0.05 3.2e-08 0.08 0.08 0.07 0.05 3.0e-08 2.9e-08 2.5e-07 1.3e-05
3 LHb gene expression Tesk1 0.39 0.19 2.3e-05 0.15 0.15 0.12 0.13 2.2e-04 2.4e-04 1.1e-03 4.9e-04
4 Brain gene expression Tesk1 0.3 0.11 0.0e+00 0.38 0.28 0.36 0.2 2.1e-37 1.5e-26 3.0e-35 4.4e-18
5 LHb mRNA stability Tesk1 0.14 0.09 1.9e-03 0.05 0.08 0.06 0.05 2.8e-02 6.0e-03 1.4e-02 2.1e-02
6 NAcc mRNA stability Tesk1 0.03 0.02 3.6e-05 0.03 0.02 0.03 0.01 8.4e-06 1.8e-04 1.6e-05 9.9e-03
7 pVTA gene expression Tesk1 0.22 0.09 0.0e+00 0.33 0.32 0.34 0.33 2.2e-27 1.7e-26 5.6e-28 6.6e-27
8 Eye gene expression Tesk1 0.34 0.2 3.6e-03 0.09 0.1 0.1 0.03 2.0e-02 1.3e-02 1.2e-02 1.1e-01
9 IL gene expression Tesk1 0.29 0.14 5.8e-07 0.24 0.22 0.23 0.28 1.7e-06 4.3e-06 2.7e-06 2.3e-07
10 NAcc gene expression Tesk1 0.18 0.09 0.0e+00 0.19 0.13 0.2 0.13 1.2e-27 6.0e-19 6.5e-29 9.6e-20
11 IC gene expression Tesk1 0.16 0.09 5.0e-07 0.12 0.13 0.13 0.12 1.4e-05 4.9e-06 6.2e-06 8.6e-06
12 PL gene expression Tesk1 0.23 0.09 0.0e+00 0.31 0.34 0.34 0.34 4.1e-34 6.6e-38 2.9e-38 7.3e-38
13 OFC gene expression Tesk1 0.27 0.13 1.1e-05 0.19 0.16 0.2 0.14 2.4e-05 1.0e-04 1.5e-05 3.5e-04
14 Liver gene expression Tesk1 0.02 0.02 5.4e-03 0.02 0.02 0.02 0.01 3.9e-03 4.2e-03 5.1e-03 8.1e-03
15 BLA gene expression Tesk1 0.57 0.18 0.0e+00 0.39 0.42 0.44 0.43 7.2e-22 4.8e-24 2.1e-25 1.2e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.93.23.61.51.71.71.91.81.71.81.91.81.81.91.81.81.91.7
Area under the delay curve0.91.02.8-0.8-0.9-1.1-1.0-0.9-1.1-1.0-0.8-1.1-1.0-1.0-1.0-0.8-0.8-1.7
BMI with tail1.96.58.52.32.72.62.42.72.52.62.92.22.52.62.32.12.92.7
BMI without tail2.37.18.32.72.92.92.82.82.72.72.82.42.62.62.42.12.72.6
Body weight2.611.216.04.03.93.53.53.83.33.43.72.83.03.02.72.23.43.3
Weight adjusted by age0.10.10.20.50.30.30.10.30.50.20.4-0.00.00.0-0.2-0.20.00.5
Bone surface0.91.61.91.31.41.21.41.41.21.31.41.11.21.21.11.01.41.3
Bone volume0.91.61.91.11.31.21.41.31.21.31.31.21.31.31.21.21.41.3
Breakpoint value in progressive ratio session3.13.77.1-0.7-1.3-1.9-2.0-1.4-1.7-1.9-1.4-2.5-2.3-2.3-2.5-2.7-1.6-1.7
Number of licking bursts3.96.37.52.52.62.72.62.62.52.62.52.52.52.52.42.22.32.7
Context. condit. distance diff. score0.00.00.2-0.4-0.3-0.3-0.2-0.2-0.2-0.3-0.3-0.1-0.2-0.1-0.1-0.0-0.00.1
Locomotion velocity, session 10.60.73.30.80.2-0.4-0.5-0.0-0.3-0.50.0-1.1-1.0-1.1-1.4-1.8-0.4-0.4
Locomotion distance, session 10.10.10.60.70.30.0-0.10.2-0.1-0.00.2-0.3-0.3-0.4-0.6-0.8-0.1-0.4
Locomotion velocity, session 23.23.84.51.81.91.82.01.92.02.02.12.02.02.02.01.92.11.6
Locomotion distance, session 21.01.33.71.91.51.41.41.31.21.31.21.01.00.80.70.50.50.4
Locomotion velocity, session 30.20.20.80.3-0.1-0.3-0.3-0.2-0.4-0.4-0.1-0.6-0.6-0.6-0.7-0.9-0.4-0.6
Locomotion distance, session 31.51.63.01.71.61.21.21.61.11.31.60.91.01.00.80.41.61.5
Stereotopy head waving bouts, day 30.81.01.9-0.2-0.6-0.8-0.8-0.7-0.7-1.0-1.0-1.0-1.1-1.2-1.3-1.4-1.4-1.0
Stereotopy head waving duration, day 30.80.91.8-0.6-0.8-0.8-0.8-0.9-0.7-1.0-1.1-0.9-1.0-1.1-1.1-1.1-1.3-0.8
Locomotion velocity, session 70.10.10.2-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.2-0.2-0.5
Locomotion distance, session 70.10.10.30.50.50.30.40.40.30.40.50.10.20.20.10.00.40.2
Stereotopy head waving bouts, day 70.80.91.81.21.20.90.91.11.00.91.00.60.70.70.50.30.91.3
Stereotopy head waving duration, day 70.30.30.70.90.70.70.70.70.70.50.50.50.50.40.30.20.30.7
Locomotion velocity, session 80.30.41.20.1-0.3-0.3-0.2-0.4-0.4-0.4-0.5-0.6-0.6-0.7-0.8-0.8-1.0-1.1
Locomotion distance, session 80.10.10.30.60.20.20.20.10.10.00.0-0.2-0.1-0.3-0.3-0.5-0.3-0.3
Degree of sensitization distance1.11.12.2-1.2-1.2-1.0-0.9-1.3-0.8-1.0-1.2-0.9-0.9-1.0-0.8-0.6-1.3-1.5
Degree of sensitization stereotypy1.41.52.71.31.41.21.21.41.11.21.41.01.01.11.00.81.41.7
Conditioned locomotion0.20.30.8-0.2-0.2-0.4-0.6-0.2-0.5-0.4-0.0-0.8-0.7-0.6-0.8-0.90.1-0.4
Cocaine response after cond. corrected3.03.65.0-1.5-1.7-1.9-1.9-1.7-1.8-1.9-1.7-2.2-2.1-2.1-2.1-2.2-1.7-1.7
Cocaine response after cond. not corrected3.03.55.1-1.3-1.6-1.8-1.7-1.7-1.7-1.9-1.8-2.2-2.0-2.1-2.1-2.3-2.0-1.8
Cocaine response before conditioning0.60.71.21.00.91.11.10.80.90.90.60.90.90.80.80.80.20.7
Saline control response0.20.31.41.20.80.60.60.60.40.50.50.20.20.10.0-0.30.20.4
Bone: connectivity density1.21.92.71.01.21.21.41.31.31.41.51.41.41.51.51.61.61.1
Bone: cortical apparent density0.30.31.1-0.10.20.50.50.30.50.50.40.80.70.70.81.00.50.4
Bone: cortical area3.75.66.81.92.32.52.52.32.32.52.32.42.62.52.62.52.22.2
Bone: cortical porosity0.10.20.3-0.5-0.5-0.5-0.4-0.4-0.3-0.4-0.5-0.3-0.3-0.3-0.3-0.2-0.4-0.5
Bone: cortical porosity0.00.00.00.10.0-0.2-0.00.0-0.1-0.1-0.0-0.0-0.1-0.0-0.0-0.10.00.1
Bone: cortical thickness1.83.04.40.81.51.81.71.51.41.81.61.72.02.02.12.11.81.8
Bone: cortical thickness0.10.10.5-0.7-0.30.0-0.1-0.3-0.3-0.1-0.3-0.1-0.0-0.00.10.1-0.00.1
Bone: cortical tissue density0.20.20.8-0.20.10.40.40.20.40.40.30.60.60.60.70.90.40.2
Condit. Reinf. active minus inactive responses0.60.71.00.80.80.90.90.80.90.80.81.00.90.80.80.80.70.6
Condit. Reinf. active-inactive response ratio0.40.50.8-0.9-0.8-0.7-0.7-0.8-0.8-0.7-0.8-0.6-0.6-0.6-0.6-0.5-0.7-0.5
Condit. Reinf. active responses3.34.15.12.12.02.12.12.02.32.01.92.22.12.02.01.91.71.7
Condit. Reinf. inactive responses4.35.36.72.22.32.52.42.32.62.32.12.52.42.32.32.31.82.0
Incentive salience index mean4.25.16.82.62.52.32.42.42.42.32.42.32.22.22.11.92.01.9
Condit. Reinf. lever presses8.411.817.84.23.93.53.63.83.73.53.73.23.33.13.02.63.02.8
Condit. Reinf. active minus inactive responses0.91.21.51.01.11.01.01.11.01.21.21.11.11.11.21.11.21.1
Condit. Reinf. active-inactive response ratio0.40.40.90.30.50.40.50.60.50.70.70.60.70.70.80.80.90.7
Condit. Reinf. active responses2.43.33.92.01.91.91.71.91.82.01.91.81.81.81.81.71.71.5
Condit. Reinf. inactive responses3.03.95.12.12.02.31.92.02.12.12.02.12.12.02.02.01.61.5
Condit. Reinf. lever presses3.95.47.12.02.22.42.22.22.42.42.22.52.52.52.52.72.11.9
Condit. Reinf. lever reinforcers received2.83.94.52.12.02.01.92.02.02.12.12.02.01.91.91.91.81.6
Conditioned reinforcement - actives0.10.10.6-0.0-0.0-0.6-0.30.10.20.10.5-0.4-0.1-0.0-0.1-0.10.8-0.1
Conditioned reinforcement - inactives0.40.61.2-0.7-0.7-1.0-1.1-0.7-0.7-0.7-0.4-1.1-0.8-0.8-0.8-0.8-0.3-0.6
Conditioned locomotion0.10.20.80.10.1-0.5-0.30.20.1-0.00.6-0.5-0.3-0.1-0.3-0.50.90.1
Patch foraging indifference point 0 sec0.20.31.30.60.3-0.4-0.50.4-0.2-0.30.4-0.9-0.7-0.6-0.9-1.10.2-0.1
Patch foraging indifference point AUC7.110.214.53.83.53.03.43.53.33.43.63.03.03.02.72.33.22.9
Delay disc. indifference point, 0s delay1.61.82.2-1.0-1.3-1.4-1.3-1.3-1.3-1.5-1.4-1.3-1.4-1.4-1.4-1.4-1.4-1.3
Delay disc. indifference point, 16s delay2.22.43.8-1.0-1.3-1.6-1.6-1.3-1.8-1.5-1.1-1.8-1.7-1.7-1.8-1.7-1.2-1.9
Delay disc. indifference point, 2s delay0.10.10.30.10.30.30.40.30.50.30.20.50.40.50.50.50.30.4
Delay disc. indifference point, 24s delay0.10.10.5-0.4-0.4-0.3-0.3-0.4-0.3-0.4-0.3-0.3-0.3-0.3-0.2-0.1-0.5-0.7
Delay disc. indifference point, 4s delay0.10.10.7-0.2-0.3-0.4-0.4-0.3-0.4-0.4-0.2-0.4-0.4-0.3-0.3-0.2-0.2-0.9
Delay disc. indifference point, 8s delay0.00.10.40.10.10.00.10.10.00.10.30.10.20.10.20.40.1-0.6
Indifference point function ln k2.44.25.3-2.3-2.2-1.8-2.2-2.2-2.1-2.2-2.2-2.0-2.0-2.0-1.9-1.7-2.1-1.8
Indifference point function log k2.44.25.3-2.3-2.2-1.8-2.2-2.2-2.1-2.2-2.2-2.0-2.0-2.0-1.9-1.7-2.1-1.8
Patch foraging total patch changes 0 sec0.20.31.11.00.8-0.0-0.00.80.20.20.8-0.5-0.2-0.1-0.4-0.70.70.4
Patch foraging total patch changes 12 sec2.33.04.01.81.91.41.72.01.71.72.01.51.51.71.51.32.02.0
Patch foraging total patch changes 18 sec0.50.71.51.21.00.70.81.00.90.91.00.70.70.70.60.50.80.7
Patch foraging total patch changes 24 sec1.52.64.32.11.91.31.71.91.71.72.01.31.31.41.20.91.81.6
Patch foraging total patch changes 6 sec1.52.34.72.22.01.11.42.01.61.52.00.81.11.20.90.61.91.3
Patch foraging time to switch 0 sec1.53.15.7-2.4-2.1-1.6-1.7-2.1-1.7-1.8-2.1-1.5-1.4-1.5-1.2-0.9-1.8-1.9
Patch foraging water rate 0 sec0.91.83.71.81.71.11.01.81.11.31.80.80.91.10.70.31.71.9
Patch foraging water rate 12 sec0.00.10.20.0-0.0-0.2-0.2-0.0-0.2-0.2-0.1-0.5-0.3-0.3-0.4-0.4-0.20.0
Patch foraging water rate 18 sec0.60.92.00.60.90.80.81.00.61.01.10.80.91.01.00.91.31.4
Patch foraging water rate 24 sec0.20.31.2-0.20.20.30.30.30.30.50.70.50.50.70.60.71.10.6
Patch foraging water rate 6 sec0.40.61.61.00.91.10.90.80.50.80.80.70.60.60.50.30.61.3
Seeking ratio, delayed vs. immediate footshock3.84.76.81.92.32.21.82.42.22.12.51.82.22.22.12.12.62.0
Distance traveled before self-admin1.82.45.02.22.02.01.61.81.41.51.81.21.41.21.00.71.21.2
Distance traveled after self-admin1.41.83.21.11.21.81.41.11.41.41.41.51.51.31.31.41.00.6
Extensor digitorum longus weight4.517.723.34.84.74.34.34.74.24.44.73.94.04.03.73.34.13.7
Bone: elastic displacement3.54.07.3-2.7-2.4-2.2-2.2-2.3-2.4-2.1-2.2-1.8-1.9-1.7-1.6-1.4-1.5-1.4
Bone: elastic work0.50.63.4-1.8-1.2-0.8-0.8-1.0-1.0-0.6-0.8-0.2-0.2-0.00.20.5-0.0-0.2
Bone: endosteal estimation0.71.63.41.91.51.31.61.41.41.31.31.11.11.01.00.60.81.2
Bone: endosteal perimeter0.71.43.11.81.51.21.41.41.31.21.30.80.90.90.80.51.01.1
Epididymis fat weight0.41.51.91.21.21.31.41.21.41.21.11.41.31.31.31.20.91.0
Delta time in closed arm before/after self-admin1.21.22.20.40.81.21.00.91.31.00.81.11.31.21.31.50.91.1
Delta time in open arm before/after self-admin0.70.72.9-0.4-0.7-1.0-0.8-0.7-0.9-0.7-0.5-0.9-0.8-0.8-0.9-0.7-0.7-1.7
Diff in mean of infusions in LGA sessions0.00.10.2-0.4-0.20.10.1-0.20.3-0.0-0.20.20.20.10.30.4-0.2-0.2
Delay discount exponential model param0.80.92.50.70.81.00.90.81.00.90.61.01.00.90.90.70.71.6
Extinction: sum of active levers before priming4.54.99.2-2.1-2.2-2.2-2.3-2.2-2.1-2.3-2.1-2.3-2.2-2.2-2.1-1.7-2.0-3.0
Active lever presses in extinction session 60.30.30.6-0.7-0.6-0.8-0.6-0.5-0.4-0.6-0.3-0.8-0.6-0.6-0.6-0.5-0.2-0.8
Bone: final force1.72.73.91.71.71.92.01.61.61.81.41.81.81.61.71.60.91.1
Bone: final moment1.52.43.51.51.51.81.91.41.51.71.31.71.71.61.71.60.81.0
Food consumed during 24 hour testing period0.40.51.01.00.91.00.90.80.70.80.80.60.70.60.50.40.40.4
Glucose2.43.84.92.22.22.01.92.22.12.02.11.71.81.81.71.41.82.0
Heart weight0.61.01.61.11.11.01.21.01.31.00.80.91.11.01.01.10.70.4
Delay discount hyperbolic model param0.50.61.90.50.60.80.70.60.80.80.50.80.80.70.80.60.51.4
Intermittent access intake day 1-15 change0.71.52.50.91.11.41.21.21.21.11.11.21.21.21.21.11.21.6
Intermittent access intake escalation0.71.42.30.81.01.41.11.11.11.11.11.21.21.21.21.11.11.5
Intermittent access intake escalation 22.32.64.50.91.31.81.51.41.51.51.51.71.81.71.81.71.72.1
Intermitt. access day 1 inactive lever presses0.31.22.01.31.31.41.01.21.21.01.20.91.00.90.80.71.01.1
Intermitt. access day 15 inactive lever presses0.00.00.20.10.20.5-0.10.10.1-0.00.3-0.20.1-0.1-0.2-0.1-0.1-0.1
Intermitt. access escalation Index0.20.30.90.90.70.80.70.60.60.30.20.40.30.30.30.1-0.21.0
Intermittent access day 1 total infusions2.03.25.6-1.5-1.6-2.4-2.1-1.5-1.7-1.8-1.1-2.3-2.0-1.8-1.9-1.9-0.9-1.5
Intermittent access day 15 total infusions0.10.10.7-0.00.2-0.1-0.00.30.30.10.5-0.10.10.30.20.20.80.6
Intermittent access terminal intake (last 3 days)0.10.20.80.00.2-0.1-0.10.30.20.10.6-0.20.10.20.20.10.90.9
Intermittent access total infusions0.10.10.6-0.00.1-0.6-0.30.20.0-0.10.5-0.6-0.3-0.1-0.2-0.30.80.4
Intermittent access day 1 locomotion1.72.24.4-1.2-1.3-2.1-1.9-1.2-1.4-1.4-0.7-1.9-1.6-1.5-1.5-1.5-0.3-1.6
Intermittent access day 15 total locomotion0.91.63.0-1.2-1.2-1.7-1.6-1.0-1.2-1.2-0.7-1.6-1.4-1.3-1.3-1.3-0.2-0.9
Intermittent access total locomotion1.11.32.8-1.5-1.2-1.7-1.5-1.0-1.1-1.1-0.6-1.4-1.2-1.0-0.9-0.80.1-0.8
Intermittent access standard deviation0.10.30.60.40.60.60.30.70.60.50.80.20.50.50.40.30.70.7
Left kidney weight0.20.93.01.71.41.11.11.21.01.01.10.60.80.60.50.40.50.2
Right kidney weight0.31.52.21.51.41.21.31.31.31.41.41.11.31.21.21.31.20.0
Cocaine induced anxiety0.20.20.5-0.4-0.5-0.3-0.4-0.5-0.5-0.5-0.7-0.2-0.5-0.5-0.5-0.5-0.7-0.2
Post-drug Anxiety0.10.20.80.90.50.40.60.40.30.3-0.10.50.20.20.1-0.0-0.30.0
Baseline Anxiety0.70.81.21.00.91.01.10.91.11.00.90.91.00.90.91.10.60.1
Tail length1.66.19.23.02.72.72.92.62.62.72.52.42.42.32.11.92.11.8
Length with tail0.83.48.22.92.41.82.22.21.92.02.11.41.51.41.30.91.61.2
Length without tail0.10.20.80.40.0-0.5-0.3-0.0-0.4-0.4-0.0-0.7-0.6-0.6-0.7-0.9-0.3-0.4
Times rat made contact with spout0.70.81.10.60.80.90.80.80.70.80.90.80.90.91.00.91.01.0
Lifetime Intake0.20.31.0-0.1-0.1-0.9-0.7-0.0-0.3-0.40.3-1.0-0.6-0.5-0.6-0.70.60.1
Liver weight, left0.10.10.4-0.1-0.3-0.2-0.1-0.3-0.2-0.3-0.5-0.4-0.3-0.4-0.2-0.2-0.6-0.7
Liver weight, right0.61.01.6-1.3-1.2-1.1-1.1-1.1-1.2-1.0-1.0-0.9-0.9-0.9-0.8-0.6-0.7-1.0
Locomotor activity0.00.00.10.10.00.10.1-0.00.0-0.00.0-0.10.0-0.0-0.00.1-0.0-0.4
Locomotor testing distance0.40.81.2-0.2-0.6-0.7-0.8-0.8-0.7-0.9-0.8-1.0-1.0-1.0-1.1-1.1-1.0-1.1
Locomotor testing rearing0.20.41.31.10.80.90.60.70.70.60.50.50.50.40.40.20.20.3
Locomotion in novel chamber0.10.10.4-0.6-0.4-0.3-0.1-0.2-0.2-0.1-0.20.00.10.20.40.50.4-0.2
Locomotion in novel chamber post-restriction2.03.34.61.21.51.72.01.51.71.81.42.12.02.02.12.11.61.9
Fecal boli incidents, locomotor time 10.30.41.4-1.0-0.8-0.6-0.7-0.7-0.6-0.7-0.6-0.4-0.5-0.4-0.3-0.1-0.4-1.2
Change in fecal boli incidents, locomotor task0.40.41.81.00.70.20.60.60.50.50.60.20.10.20.1-0.40.51.3
Time >=10cm from walls, locomotor time 10.20.20.90.30.0-0.2-0.4-0.1-0.6-0.4-0.3-0.5-0.5-0.5-0.6-1.0-0.4-0.1
Bouts of movement, locomotor time 11.61.83.3-1.5-1.5-1.4-1.2-1.5-1.2-1.4-1.5-1.1-1.3-1.2-1.2-0.9-1.2-1.8
Total resting periods, locomotor time 11.71.93.1-1.8-1.6-1.4-1.3-1.6-1.2-1.4-1.6-1.0-1.2-1.1-1.0-0.7-1.3-1.7
Rest time, locomotor task time 10.30.31.8-1.3-0.9-0.2-0.0-0.80.0-0.3-0.70.40.00.10.30.6-0.4-0.2
Distance moved, locomotor task time 10.40.62.81.71.20.60.61.10.20.71.00.20.30.30.1-0.30.70.7
Vertical activity count, locomotor time 10.10.31.91.40.60.00.10.4-0.5-0.10.1-0.4-0.4-0.5-0.6-1.0-0.50.1
Time >=10cm from walls, locomotor time 20.00.00.10.30.20.3-0.00.20.30.10.1-0.00.1-0.0-0.00.1-0.1-0.2
Bouts of movement, locomotor time 20.30.50.80.80.80.70.60.80.90.70.80.60.60.60.50.60.8-0.2
Total resting periods, locomotor time 20.10.20.40.40.40.30.30.50.50.40.50.30.40.40.30.40.6-0.3
Rest time, locomotor task time 20.50.71.1-1.0-1.0-1.0-0.7-1.0-0.9-0.8-1.0-0.5-0.8-0.7-0.7-0.8-0.8-0.3
Distance moved, locomotor task time 20.80.91.60.70.81.21.00.80.90.90.81.01.21.01.11.30.60.6
Vertical activity count, locomotor time 20.20.30.91.00.70.90.60.50.40.40.30.50.60.30.50.5-0.00.3
Light reinforcement 10.20.62.11.30.60.4-0.20.2-0.2-0.20.1-0.8-0.6-0.8-1.1-1.4-0.7-0.8
Light reinforcement 20.81.24.40.7-0.2-0.8-0.6-0.4-0.8-0.9-0.7-1.2-1.3-1.4-1.6-2.1-1.2-0.9
Bone: marrow area0.92.03.71.91.71.51.71.51.51.41.41.31.21.21.20.91.01.4
Bone: maximum diameter3.05.66.92.32.42.42.62.42.52.42.32.32.42.42.42.32.02.1
Bone: maximum force3.46.17.72.52.62.72.82.52.52.62.42.52.62.52.52.41.91.7
Bone: maximum moment3.05.36.72.32.32.52.62.22.32.52.22.42.52.32.42.41.71.6
Mean time between licks in bursts0.30.82.8-0.7-1.0-0.6-0.5-1.1-0.7-0.8-1.3-0.6-0.6-0.8-0.6-0.5-1.7-1.3
Mean num. licks in bursts1.62.53.1-1.7-1.8-1.8-1.6-1.7-1.7-1.6-1.6-1.5-1.5-1.5-1.4-1.2-1.4-1.6
Cd content in liver0.50.61.11.00.90.91.00.80.80.80.70.60.70.60.50.20.40.9
Co content in liver1.11.32.2-0.6-0.9-1.0-1.0-1.1-1.3-1.1-1.3-1.0-1.2-1.3-1.3-1.4-1.5-1.0
Cu content in liver1.61.93.2-1.6-1.6-1.2-1.2-1.6-1.3-1.4-1.8-1.1-1.3-1.3-1.2-1.0-1.7-1.2
Fe content in liver1.92.33.8-1.0-1.3-1.3-1.4-1.5-1.7-1.4-1.3-1.5-1.5-1.7-1.7-1.7-1.4-1.9
K content in liver0.60.60.9-0.3-0.6-0.8-0.7-0.7-0.7-0.8-0.7-0.7-0.8-0.9-0.9-1.0-0.8-0.8
Mg content in liver0.70.71.4-0.8-0.9-1.2-0.8-0.8-0.9-1.0-0.9-0.8-0.9-0.8-0.6-0.7-0.9-0.5
Mn content in liver1.82.02.71.11.31.41.51.31.51.51.31.51.61.51.61.61.31.3
Na content in liver1.92.04.5-1.3-1.5-1.1-1.0-1.7-1.4-1.4-2.0-1.0-1.2-1.4-1.1-1.0-2.1-1.4
Rb content in liver5.96.89.1-2.6-2.8-2.6-2.5-2.8-3.0-2.7-2.8-2.4-2.6-2.6-2.4-2.3-2.7-2.4
Se content in liver2.83.35.21.51.81.91.91.82.31.81.71.71.91.91.92.01.71.4
Sr content in liver0.40.31.00.60.60.40.40.71.00.50.40.40.60.60.50.70.30.2
Zn content in liver0.10.10.40.30.20.40.50.20.30.30.20.60.40.40.50.50.30.1
Bone: minimum diameter0.00.10.2-0.20.10.00.40.10.30.20.10.20.30.30.40.40.30.3
Time in familiar zone, hab. session 10.50.51.7-0.7-0.10.20.20.20.30.40.20.70.70.91.01.30.90.9
Time in novel zone, hab. session 14.74.77.5-1.1-1.8-1.8-1.8-2.0-2.0-2.0-2.1-2.1-2.2-2.4-2.5-2.5-2.7-2.7
Total zone transitions, hab. session 10.00.00.00.10.00.10.20.00.20.1-0.00.20.20.10.10.2-0.1-0.2
Total locomotion distance, hab. session 10.91.32.40.70.81.11.20.91.31.10.81.41.31.31.41.60.70.9
Locomotion velocity, hab. session 12.33.34.41.61.71.81.91.72.11.81.62.12.01.92.02.01.41.5
Time in familiar zone, hab. session 20.20.20.9-0.9-0.6-0.3-0.3-0.5-0.2-0.3-0.50.10.00.10.20.6-0.2-0.3
Time in novel zone, hab. session 22.82.84.7-1.0-1.4-1.6-1.6-1.5-1.8-1.6-1.5-1.9-1.9-1.9-2.0-2.2-1.6-1.5
Total zone transitions, hab. session 20.20.21.11.00.70.50.60.60.50.50.60.30.30.20.2-0.00.30.1
Total locomotion distance, hab. session 20.81.11.51.21.11.11.11.11.21.01.01.01.01.00.90.80.90.9
Locomotion velocity, hab. session 21.11.52.11.41.31.21.31.31.41.31.21.21.21.21.21.11.11.1
Novel to familiar place preference ratio5.05.56.4-1.9-2.2-2.4-2.3-2.2-2.5-2.4-2.3-2.4-2.5-2.4-2.4-2.4-2.3-2.3
Novelty place preference6.26.67.9-2.3-2.5-2.6-2.6-2.5-2.8-2.7-2.6-2.6-2.7-2.7-2.6-2.6-2.5-2.4
Time in novel zone, NPP test7.78.29.5-2.5-2.8-2.9-2.8-2.8-3.1-2.9-2.9-2.9-3.0-3.0-2.9-2.9-2.8-2.8
Total zone transitions, NPP test0.20.31.41.20.80.60.60.60.60.50.60.30.40.20.1-0.10.2-0.0
Total locomotion distance, NPP test1.21.63.51.91.61.31.31.51.41.31.51.01.11.00.80.61.21.1
Locomotion velocity, NPP test1.92.74.62.11.91.61.61.91.81.71.91.41.41.41.21.01.71.5
Intraocular pressure1.82.64.32.12.01.51.61.91.61.61.91.21.41.41.20.81.61.9
Delta distance traveled before/after self-admin0.00.00.2-0.3-0.30.00.0-0.30.1-0.0-0.20.20.10.00.10.2-0.4-0.2
Delta ambulatory time before/after self-admin0.30.40.9-0.9-0.9-0.5-0.4-0.9-0.4-0.5-0.8-0.2-0.4-0.5-0.3-0.1-0.9-0.7
Parametrial fat weight0.30.71.2-0.3-0.5-0.5-0.7-0.7-0.8-0.6-0.7-1.0-0.8-1.0-1.0-1.1-1.0-1.0
Pavlov. Cond. lever latency5.87.410.2-3.2-3.0-2.8-2.8-3.0-3.0-2.8-2.9-2.5-2.6-2.5-2.4-2.2-2.5-2.3
Pavlov. Cond. magazine entry latency0.60.71.10.90.91.00.90.81.00.90.90.90.90.80.90.90.60.3
Pavlov. Cond. change in total contacts2.32.53.71.91.81.61.61.71.71.61.81.41.51.41.31.11.51.3
Pavlov. Cond. index score3.24.05.22.22.12.12.12.12.32.12.02.02.01.91.91.91.61.4
Pavlov. Cond. latency score2.93.64.72.12.01.91.92.02.22.02.01.91.91.81.81.71.61.4
Pavlov. Cond. lever contacts5.87.09.13.02.92.72.72.92.82.72.92.52.62.52.42.22.52.2
Pavlov. Cond. magazine entry number0.91.21.4-1.0-1.1-1.2-1.0-1.1-1.2-1.1-1.1-1.1-1.1-1.1-1.1-1.1-0.9-0.8
Pavlov. Cond. intertrial magazine entries0.20.30.50.60.50.50.60.50.60.50.50.70.60.50.50.50.40.3
Pavlov. Cond. lever-magazine prob. diff.3.54.35.72.22.12.22.12.12.42.12.12.12.22.12.12.01.81.5
Pavlov. Cond. response bias3.84.66.02.52.32.32.22.32.42.32.32.12.22.02.01.91.91.6
Pavlov. Cond. lever latency3.54.85.9-2.0-2.1-2.3-2.2-2.1-2.3-2.3-2.1-2.4-2.4-2.3-2.3-2.4-1.9-1.8
Pavlov. Cond. magazine entry latency0.20.20.6-0.5-0.6-0.3-0.4-0.6-0.3-0.3-0.6-0.1-0.1-0.2-0.10.2-0.7-0.8
Pavlov. Cond. change in total contacts1.62.55.11.01.21.71.61.21.71.61.22.01.91.82.02.31.01.1
Pavlov. Cond. index score0.70.92.30.50.61.00.90.61.01.00.61.21.21.11.31.50.50.5
Pavlov. Cond. latency score1.01.32.80.60.81.11.00.81.21.10.81.41.41.31.51.70.80.8
Pavlov. Cond. lever contacts2.73.74.91.71.82.01.91.82.12.01.72.12.12.02.12.21.51.5
Pavlov. Cond. magazine entry number0.50.62.0-0.2-0.4-0.8-0.6-0.4-0.8-0.8-0.4-1.1-1.0-1.0-1.2-1.4-0.4-0.4
Pavlov. Cond. intertrial magazine entries0.30.41.10.70.70.50.60.70.50.50.70.40.40.50.50.20.81.0
Pavlov. Cond. lever-magazine prob. diff.0.81.02.50.50.61.00.90.71.01.00.61.31.31.21.41.60.50.6
Pavlov. Cond. response bias1.52.03.61.11.21.51.41.21.51.41.11.71.61.51.71.90.90.9
Time in closed arm before self-admin0.20.30.6-0.7-0.6-0.7-0.8-0.5-0.7-0.5-0.4-0.5-0.6-0.4-0.5-0.50.2-0.3
Time in closed arm after self-admin0.10.10.6-0.6-0.20.2-0.0-0.10.20.1-0.20.30.30.30.40.40.30.8
Time in open arm before self-admin0.40.51.61.30.90.60.90.80.80.60.60.40.50.40.40.10.20.9
Time in open arm after self-admin0.30.31.41.20.80.20.50.80.50.50.90.20.30.30.20.20.5-0.2
Bone: periosteal estimation1.94.05.32.12.12.12.32.02.02.12.01.92.01.92.01.71.61.8
Bone: periosteal perimeter0.40.71.11.11.00.91.01.00.90.90.90.60.70.70.70.50.70.7
Bone: post-yield work1.42.04.62.11.71.51.61.61.61.51.51.31.31.11.00.80.90.9
Progressive ratio test 1 active lever presses1.21.53.6-0.8-0.9-1.6-1.5-0.8-1.2-1.3-0.4-1.9-1.5-1.3-1.5-1.6-0.1-0.5
Progressive ratio test 1 breakpoint1.01.23.0-0.7-0.8-1.4-1.4-0.7-1.1-1.1-0.3-1.7-1.3-1.2-1.3-1.40.0-0.4
Progressive ratio test 1 inactive lever presses0.20.20.80.90.60.1-0.10.50.10.10.7-0.5-0.2-0.2-0.4-0.70.50.3
Progressive ratio test 2 active lever presses1.82.14.1-0.9-1.2-1.9-1.8-1.1-1.3-1.5-0.7-2.0-1.7-1.6-1.6-1.7-0.5-1.0
Progressive ratio test 2 breakpoint1.92.24.4-1.0-1.2-2.0-1.8-1.1-1.4-1.5-0.7-2.1-1.7-1.6-1.7-1.8-0.6-1.0
Progressive ratio test 2 inactive lever presses0.10.10.60.20.2-0.3-0.10.30.20.10.6-0.3-0.00.1-0.0-0.10.80.5
Incentive Sensitization - Responses0.60.91.4-0.6-0.8-1.1-1.2-0.8-1.0-1.0-0.7-1.1-1.1-1.1-1.1-1.1-0.7-0.8
Incentive Sensitization - Breakpoint0.81.01.5-0.6-0.8-1.1-1.2-0.8-1.0-1.0-0.8-1.2-1.1-1.1-1.1-1.2-0.7-0.8
Sum of active levers in priming session hrs 5-65.04.76.0-1.8-2.0-2.3-2.3-2.0-2.0-2.3-1.9-2.4-2.3-2.3-2.4-2.3-1.7-2.3
Progressive ratio0.00.00.2-0.0-0.0-0.1-0.1-0.0-0.0-0.10.1-0.3-0.0-0.1-0.00.00.1-0.5
Food seeking constrained by brief footshock4.15.010.63.32.91.92.22.82.22.22.71.61.81.91.61.12.31.9
Seeking ratio, punishment vs. effort1.21.73.21.81.61.21.31.61.31.31.31.21.11.21.00.71.11.5
Retroperitoneal fat weight0.21.02.0-1.4-1.2-0.8-0.9-1.2-0.9-1.0-1.4-0.7-0.7-0.8-0.6-0.3-1.4-1.0
Reaction time number correct0.00.00.20.40.3-0.10.10.2-0.10.20.3-0.1-0.0-0.0-0.1-0.20.2-0.2
Reaction time mean minus median0.92.25.40.50.91.61.31.01.61.40.91.91.81.82.02.30.81.1
Reaction time mean minus median AUC1.12.85.11.01.31.71.61.41.91.71.22.11.91.92.12.31.11.3
Reaction time num false alarms0.20.20.70.20.30.40.50.30.30.40.40.70.60.60.70.80.5-0.1
Reaction time num false alarms AUC0.40.60.90.80.80.80.80.80.60.80.90.90.80.80.80.80.90.2
Reaction time trials correct on left0.00.00.20.40.3-0.10.10.2-0.10.20.3-0.1-0.0-0.0-0.1-0.20.2-0.2
Reaction time trials on left0.00.00.10.30.2-0.2-0.00.1-0.20.10.2-0.1-0.1-0.1-0.2-0.20.1-0.3
Reaction time mean0.30.52.0-1.4-1.1-0.2-0.5-1.0-0.3-0.5-1.10.1-0.0-0.20.20.5-0.9-0.3
Reaction time mean AUC0.30.62.3-1.5-1.2-0.3-0.6-1.1-0.4-0.6-1.10.0-0.1-0.20.20.5-0.9-0.5
Median of all reaction times1.42.04.3-2.1-1.9-1.1-1.4-1.9-1.3-1.5-1.9-0.9-1.0-1.2-0.8-0.6-1.7-1.1
Reaction time omissions1.62.33.2-1.8-1.7-1.3-1.4-1.7-1.2-1.6-1.8-1.3-1.4-1.4-1.3-1.2-1.8-1.4
Reaction time false alarm rate0.10.10.3-0.10.00.30.30.10.10.10.10.50.30.30.40.60.3-0.1
Reaction time premature initiation rate1.21.74.3-2.1-1.6-1.2-1.5-1.4-1.5-1.5-1.4-1.2-1.1-1.0-0.9-0.7-1.2-0.4
Reaction time premature initiations0.71.32.7-1.7-1.3-1.1-1.4-1.2-1.4-1.3-1.1-1.1-1.0-0.9-0.9-0.7-0.9-0.4
Std. dev. reaction times0.30.62.4-0.30.00.80.50.10.90.5-0.01.21.00.91.21.5-0.10.4
Reaction time trials completed0.00.00.10.30.2-0.2-0.00.1-0.20.10.2-0.1-0.1-0.1-0.2-0.20.1-0.3
Reaction time trials AUC0.00.00.10.30.2-0.20.00.1-0.20.10.2-0.1-0.1-0.1-0.1-0.20.1-0.2
Run reversals in cocaine runway, females0.20.20.50.20.20.30.40.20.00.50.10.60.60.50.70.60.20.7
Run reversals in cocaine runway, males0.00.00.1-0.3-0.2-0.3-0.3-0.1-0.1-0.2-0.0-0.2-0.2-0.1-0.10.10.1-0.3
Latency to leave start box in cocaine runway0.80.91.30.81.01.10.90.90.91.01.10.80.90.90.90.71.11.0
Latency to leave start box in cocaine runway, F0.20.20.4-0.4-0.3-0.3-0.6-0.3-0.4-0.3-0.1-0.7-0.4-0.5-0.5-0.5-0.0-0.5
Latency to leave start box in cocaine runway, M2.11.92.71.71.61.61.51.51.31.41.41.41.31.31.20.91.21.4
Std. dev. time between licks in bursts0.30.40.8-0.6-0.7-0.7-0.5-0.7-0.6-0.6-0.7-0.5-0.5-0.5-0.5-0.3-0.6-0.9
Total sessions with >9 infusions0.40.51.5-0.0-0.3-0.9-0.9-0.3-0.6-0.60.2-1.2-0.9-0.9-1.0-1.10.2-0.6
Short access day 1 total inactive lever presses0.20.30.70.80.60.3-0.00.5-0.10.20.8-0.4-0.1-0.2-0.3-0.80.80.8
Short access day 10 total inactive lever presses0.41.01.80.91.11.40.91.01.20.91.01.01.00.90.90.80.71.2
Short access day 1 total infusions0.40.61.80.1-0.2-0.8-0.8-0.3-0.5-0.60.1-1.3-0.9-0.9-1.0-1.30.1-0.2
Short access day 10 total infusions0.70.92.1-0.2-0.5-1.1-1.1-0.5-1.0-0.9-0.3-1.4-1.2-1.1-1.2-1.5-0.2-0.4
Short access total infusions1.11.43.4-0.5-0.8-1.5-1.4-0.8-1.2-1.2-0.4-1.8-1.4-1.4-1.5-1.7-0.3-0.7
Short access day 1 locomotion1.92.44.7-1.3-1.4-1.7-1.9-1.4-1.7-1.6-0.8-2.2-1.6-1.6-1.5-1.6-0.5-1.6
Short access day 10 total locomotion0.30.61.4-1.2-0.9-1.0-1.0-0.8-0.5-0.7-0.4-0.8-0.6-0.5-0.4-0.20.0-1.1
Short access total locomotion0.70.91.7-0.6-0.7-1.2-1.1-0.8-0.9-0.9-0.3-1.3-1.1-1.0-1.0-1.10.0-1.1
One hour access (0.3 mA shock)0.10.10.50.50.2-0.7-0.10.30.10.00.3-0.4-0.3-0.1-0.2-0.40.40.3
Compulsive drug intake0.60.72.00.50.60.70.90.70.70.90.51.11.01.01.11.40.50.3
One hour access (shock baseline)0.40.51.70.1-0.2-1.1-0.8-0.2-0.3-0.60.1-1.2-1.0-0.9-1.0-1.30.0-0.0
Social response proportion1.61.94.3-1.6-1.7-1.1-1.0-1.7-1.1-1.4-2.1-0.8-1.0-1.1-0.9-0.5-2.0-1.3
Social responses0.70.81.21.11.01.01.10.91.10.90.71.01.00.90.90.90.50.6
Social time0.30.41.9-0.2-0.6-0.2-0.2-0.7-0.3-0.5-1.0-0.2-0.3-0.6-0.5-0.3-1.4-1.2
Soleus weight0.51.63.70.2-0.5-0.8-0.7-0.8-1.0-1.0-1.0-1.4-1.4-1.5-1.7-1.9-1.7-1.7
Bone: stiffness4.16.69.32.82.73.03.12.52.72.82.42.72.82.52.62.51.61.6
Tibialis anterior weight6.120.732.45.75.34.94.85.14.64.85.04.14.24.13.73.04.24.2
Time to tail flick, vehicle, before self-admin0.10.20.6-0.7-0.5-0.7-0.5-0.4-0.2-0.3-0.3-0.3-0.4-0.1-0.1-0.10.40.1
Time to tail flick, vehicle, after self-admin0.10.10.40.00.30.30.20.30.20.20.30.20.30.40.40.50.60.6
Time to tail flick, test, before self-admin0.50.50.90.80.70.40.90.80.80.70.50.70.60.70.70.50.80.9
Time to tail flick, test, after self-admin4.34.55.51.51.91.82.22.02.22.22.12.22.22.32.32.32.22.2
Delta time to tail flick, vehicle, before/after SA0.10.10.30.40.30.60.40.30.20.20.10.30.50.30.30.4-0.20.2
Delta time to tail flick, test, before/after SA0.30.30.7-0.10.20.60.30.30.40.50.70.50.60.60.60.80.60.2
Tibia length0.20.71.70.2-0.3-0.3-0.2-0.6-0.7-0.5-0.6-0.8-0.7-1.0-1.0-1.3-1.2-1.3
Ambulatory time before self-admin1.11.73.81.91.71.61.31.51.11.31.70.91.10.90.70.51.20.9
Ambulatory time after self-admin0.30.40.70.70.60.80.70.50.60.60.80.60.60.50.40.40.5-0.1
Bone: tissue strength0.20.20.40.50.20.60.50.10.40.3-0.10.60.50.30.50.6-0.6-0.5
Total heroin consumption2.83.34.9-1.2-1.5-1.7-1.9-1.6-1.8-1.9-1.4-2.2-2.0-2.0-2.1-2.0-1.6-2.0
Bone: trabecular number1.62.63.11.31.51.51.81.61.71.71.61.71.71.71.71.81.61.3
Bone: trabecular spacing0.00.00.2-0.00.10.30.00.10.10.10.10.30.20.20.30.30.10.4
Bone: trabecular thickness0.00.00.2-0.4-0.3-0.3-0.1-0.20.0-0.1-0.1-0.10.00.00.10.30.1-0.3
Bone: trabecular tissue density2.23.25.62.42.02.22.01.82.02.01.71.91.91.61.61.40.91.1
Water consumed over 24 hours0.91.21.70.91.21.11.11.20.91.21.21.01.11.11.11.01.31.3
Number of responses in last shaping day2.02.25.6-0.2-0.8-1.1-1.4-1.0-1.3-1.5-0.9-2.0-1.8-1.9-2.0-2.4-1.2-1.3