Hub : Genes

Krt5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye intron excision ratio chr7_134711342_134729940 0.46 0.18 8.7e-05 0.13 0.18 0.16 0.16 5.7e-03 1.0e-03 1.7e-03 1.9e-03
2 Eye intron excision ratio chr7_134729414_134729940 0.44 0.16 5.3e-05 0.11 0.19 0.16 0.16 9.9e-03 8.0e-04 2.1e-03 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.20.40.40.7-0.6
Area under the delay curve0.10.20.20.4-0.4
BMI with tail2.27.78.02.8-2.7
BMI without tail0.52.62.61.6-1.6
Body weight0.52.12.31.5-1.4
Weight adjusted by age0.20.60.60.8-0.7
Bone surface0.61.11.21.1-1.0
Bone volume0.81.51.61.3-1.2
Breakpoint value in progressive ratio session0.20.30.30.5-0.5
Number of licking bursts0.00.00.10.2-0.2
Context. condit. distance diff. score0.00.00.00.1-0.1
Locomotion velocity, session 15.25.96.0-2.42.4
Locomotion distance, session 11.11.41.4-1.21.2
Locomotion velocity, session 23.54.24.2-2.02.1
Locomotion distance, session 21.42.02.0-1.41.4
Locomotion velocity, session 35.66.46.4-2.52.5
Locomotion distance, session 35.25.96.0-2.42.4
Stereotopy head waving bouts, day 32.32.82.81.7-1.7
Stereotopy head waving duration, day 30.10.20.20.4-0.4
Locomotion velocity, session 70.91.01.1-1.01.0
Locomotion distance, session 73.74.74.9-2.22.2
Stereotopy head waving bouts, day 74.75.45.52.3-2.3
Stereotopy head waving duration, day 72.83.53.51.9-1.9
Locomotion velocity, session 80.10.10.1-0.30.3
Locomotion distance, session 81.92.72.8-1.71.6
Degree of sensitization distance0.40.50.50.7-0.7
Degree of sensitization stereotypy2.93.23.21.8-1.8
Conditioned locomotion0.40.40.4-0.60.7
Cocaine response after cond. corrected0.00.00.00.0-0.0
Cocaine response after cond. not corrected0.00.00.0-0.10.2
Cocaine response before conditioning0.70.90.9-1.00.9
Saline control response0.00.00.0-0.10.1
Bone: connectivity density0.00.10.1-0.20.3
Bone: cortical apparent density1.01.51.51.2-1.2
Bone: cortical area0.81.41.41.2-1.1
Bone: cortical porosity1.41.51.6-1.21.3
Bone: cortical porosity1.41.51.6-1.21.3
Bone: cortical thickness0.30.40.50.7-0.6
Bone: cortical thickness0.91.11.1-1.01.1
Bone: cortical tissue density0.81.31.31.1-1.1
Condit. Reinf. active minus inactive responses0.30.30.3-0.60.6
Condit. Reinf. active-inactive response ratio0.50.50.5-0.70.7
Condit. Reinf. active responses0.81.01.0-1.01.0
Condit. Reinf. inactive responses0.70.90.9-0.91.0
Incentive salience index mean0.00.00.0-0.20.1
Condit. Reinf. lever presses0.40.60.70.8-0.8
Condit. Reinf. active minus inactive responses1.01.61.61.2-1.3
Condit. Reinf. active-inactive response ratio0.30.50.50.7-0.7
Condit. Reinf. active responses1.21.71.81.3-1.3
Condit. Reinf. inactive responses0.10.10.20.4-0.4
Condit. Reinf. lever presses0.30.40.4-0.70.6
Condit. Reinf. lever reinforcers received0.40.50.60.7-0.7
Conditioned reinforcement - actives0.00.00.1-0.20.1
Conditioned reinforcement - inactives0.20.40.5-0.70.6
Conditioned locomotion0.10.10.2-0.40.3
Patch foraging indifference point 0 sec0.20.70.8-0.90.8
Patch foraging indifference point AUC0.10.20.20.4-0.5
Delay disc. indifference point, 0s delay0.00.00.00.0-0.0
Delay disc. indifference point, 16s delay0.10.10.10.3-0.3
Delay disc. indifference point, 2s delay6.37.07.12.6-2.7
Delay disc. indifference point, 24s delay0.10.10.10.3-0.3
Delay disc. indifference point, 4s delay0.20.20.20.5-0.5
Delay disc. indifference point, 8s delay0.10.20.2-0.40.4
Indifference point function ln k0.00.00.00.2-0.1
Indifference point function log k0.00.00.00.2-0.1
Patch foraging total patch changes 0 sec0.51.51.6-1.31.2
Patch foraging total patch changes 12 sec0.10.20.2-0.40.3
Patch foraging total patch changes 18 sec0.20.50.5-0.70.6
Patch foraging total patch changes 24 sec0.00.00.0-0.20.1
Patch foraging total patch changes 6 sec0.10.10.1-0.40.3
Patch foraging time to switch 0 sec0.00.10.10.4-0.4
Patch foraging water rate 0 sec0.00.00.00.0-0.0
Patch foraging water rate 12 sec0.20.80.8-0.90.9
Patch foraging water rate 18 sec0.00.00.00.0-0.0
Patch foraging water rate 24 sec0.30.50.50.7-0.7
Patch foraging water rate 6 sec0.00.00.1-0.20.2
Seeking ratio, delayed vs. immediate footshock0.00.00.0-0.20.2
Distance traveled before self-admin0.00.00.0-0.10.1
Distance traveled after self-admin1.01.71.8-1.41.3
Extensor digitorum longus weight8.433.333.95.8-5.7
Bone: elastic displacement4.55.65.7-2.42.4
Bone: elastic work2.93.83.9-1.92.0
Bone: endosteal estimation0.41.11.11.1-1.0
Bone: endosteal perimeter0.92.22.31.5-1.5
Epididymis fat weight1.89.09.2-3.03.0
Delta time in closed arm before/after self-admin0.10.10.10.2-0.3
Delta time in open arm before/after self-admin3.44.04.1-2.02.0
Diff in mean of infusions in LGA sessions0.40.80.80.9-0.8
Delay discount exponential model param0.20.30.3-0.50.5
Extinction: sum of active levers before priming1.11.71.71.3-1.3
Active lever presses in extinction session 60.00.00.0-0.20.1
Bone: final force0.50.70.80.9-0.8
Bone: final moment0.50.70.80.9-0.8
Food consumed during 24 hour testing period0.30.60.6-0.80.8
Glucose0.40.60.6-0.80.8
Heart weight0.10.10.1-0.30.3
Delay discount hyperbolic model param0.40.50.5-0.70.7
Intermittent access intake day 1-15 change0.10.60.6-0.80.7
Intermittent access intake escalation0.00.20.2-0.40.4
Intermittent access intake escalation 20.20.40.4-0.60.6
Intermitt. access day 1 inactive lever presses0.11.01.01.0-1.0
Intermitt. access day 15 inactive lever presses0.00.00.0-0.10.1
Intermitt. access escalation Index0.72.22.31.4-1.5
Intermittent access day 1 total infusions0.00.00.0-0.10.0
Intermittent access day 15 total infusions0.00.10.1-0.30.2
Intermittent access terminal intake (last 3 days)0.00.00.0-0.1-0.1
Intermittent access total infusions0.00.00.10.1-0.3
Intermittent access day 1 locomotion0.00.00.1-0.20.1
Intermittent access day 15 total locomotion0.51.91.9-1.41.4
Intermittent access total locomotion0.30.30.4-0.60.5
Intermittent access standard deviation0.31.81.8-1.41.3
Left kidney weight0.00.10.20.4-0.3
Right kidney weight0.10.70.80.9-0.8
Cocaine induced anxiety0.00.00.0-0.10.1
Post-drug Anxiety0.10.10.1-0.30.3
Baseline Anxiety0.00.00.00.00.1
Tail length0.31.41.4-1.21.2
Length with tail0.10.40.4-0.60.6
Length without tail0.00.00.10.2-0.2
Times rat made contact with spout0.40.50.5-0.70.7
Lifetime Intake0.00.00.0-0.1-0.1
Liver weight, left0.40.60.70.8-0.8
Liver weight, right0.00.00.00.00.1
Locomotor activity0.10.10.1-0.40.4
Locomotor testing distance0.30.70.7-0.80.8
Locomotor testing rearing0.20.70.7-0.80.8
Locomotion in novel chamber2.12.92.91.7-1.7
Locomotion in novel chamber post-restriction0.10.20.30.4-0.5
Fecal boli incidents, locomotor time 11.64.34.3-2.12.1
Change in fecal boli incidents, locomotor task0.80.80.80.9-0.9
Time >=10cm from walls, locomotor time 10.50.70.7-0.80.8
Bouts of movement, locomotor time 10.30.40.4-0.60.6
Total resting periods, locomotor time 11.11.31.3-1.11.1
Rest time, locomotor task time 10.50.90.9-1.00.9
Distance moved, locomotor task time 10.51.31.31.1-1.2
Vertical activity count, locomotor time 10.43.03.11.7-1.7
Time >=10cm from walls, locomotor time 20.10.30.3-0.50.5
Bouts of movement, locomotor time 20.82.52.61.6-1.6
Total resting periods, locomotor time 20.83.23.31.8-1.8
Rest time, locomotor task time 20.10.10.1-0.30.3
Distance moved, locomotor task time 20.00.00.00.1-0.1
Vertical activity count, locomotor time 20.10.30.30.6-0.6
Light reinforcement 10.00.00.0-0.20.1
Light reinforcement 20.10.10.1-0.40.4
Bone: marrow area0.41.01.01.0-1.0
Bone: maximum diameter0.61.21.21.1-1.1
Bone: maximum force1.01.92.01.4-1.4
Bone: maximum moment0.91.81.81.4-1.3
Mean time between licks in bursts0.31.71.8-1.31.3
Mean num. licks in bursts0.30.91.0-0.91.0
Cd content in liver0.30.30.4-0.60.6
Co content in liver0.20.20.20.5-0.5
Cu content in liver0.70.80.90.9-0.9
Fe content in liver0.00.10.1-0.30.2
K content in liver0.10.10.10.2-0.2
Mg content in liver0.10.10.1-0.30.3
Mn content in liver0.00.00.00.1-0.1
Na content in liver0.00.00.00.2-0.2
Rb content in liver0.00.00.0-0.20.1
Se content in liver0.81.01.0-1.01.0
Sr content in liver0.40.30.3-0.50.6
Zn content in liver0.91.01.0-1.01.0
Bone: minimum diameter1.12.12.21.5-1.4
Time in familiar zone, hab. session 10.40.50.5-0.70.7
Time in novel zone, hab. session 12.02.22.31.4-1.5
Total zone transitions, hab. session 10.30.40.50.6-0.7
Total locomotion distance, hab. session 10.40.50.5-0.70.7
Locomotion velocity, hab. session 10.50.70.7-0.80.8
Time in familiar zone, hab. session 20.00.00.0-0.20.2
Time in novel zone, hab. session 20.40.50.50.7-0.7
Total zone transitions, hab. session 20.30.40.4-0.60.6
Total locomotion distance, hab. session 20.50.70.7-0.80.9
Locomotion velocity, hab. session 20.81.11.1-1.01.1
Novel to familiar place preference ratio0.81.01.11.0-1.0
Novelty place preference0.50.70.70.8-0.8
Time in novel zone, NPP test0.70.90.91.0-0.9
Total zone transitions, NPP test0.81.21.3-1.11.1
Total locomotion distance, NPP test2.43.43.4-1.81.8
Locomotion velocity, NPP test2.84.04.1-2.02.0
Intraocular pressure0.50.81.0-1.00.9
Delta distance traveled before/after self-admin4.04.44.4-2.12.1
Delta ambulatory time before/after self-admin2.13.63.6-1.91.9
Parametrial fat weight1.12.52.6-1.61.5
Pavlov. Cond. lever latency1.62.02.1-1.41.5
Pavlov. Cond. magazine entry latency2.73.53.61.8-1.9
Pavlov. Cond. change in total contacts4.14.44.42.1-2.1
Pavlov. Cond. index score4.65.85.92.4-2.4
Pavlov. Cond. latency score4.35.45.62.3-2.4
Pavlov. Cond. lever contacts1.82.22.31.4-1.5
Pavlov. Cond. magazine entry number2.02.52.6-1.61.6
Pavlov. Cond. intertrial magazine entries2.22.62.6-1.61.6
Pavlov. Cond. lever-magazine prob. diff.4.55.55.72.3-2.4
Pavlov. Cond. response bias1.31.61.61.2-1.3
Pavlov. Cond. lever latency1.41.92.01.4-1.4
Pavlov. Cond. magazine entry latency2.84.04.0-2.02.0
Pavlov. Cond. change in total contacts0.41.01.11.0-1.0
Pavlov. Cond. index score1.52.42.4-1.61.5
Pavlov. Cond. latency score1.42.32.3-1.51.5
Pavlov. Cond. lever contacts1.92.92.9-1.71.7
Pavlov. Cond. magazine entry number0.91.21.21.1-1.1
Pavlov. Cond. intertrial magazine entries0.51.21.2-1.11.1
Pavlov. Cond. lever-magazine prob. diff.1.11.71.7-1.31.3
Pavlov. Cond. response bias1.82.52.5-1.61.6
Time in closed arm before self-admin1.01.81.81.4-1.3
Time in closed arm after self-admin3.23.73.81.9-1.9
Time in open arm before self-admin1.01.21.31.1-1.1
Time in open arm after self-admin0.80.91.0-0.91.0
Bone: periosteal estimation0.92.22.21.5-1.4
Bone: periosteal perimeter1.93.73.92.0-1.9
Bone: post-yield work0.40.70.70.8-0.8
Progressive ratio test 1 active lever presses0.40.70.9-0.90.8
Progressive ratio test 1 breakpoint0.61.01.1-1.10.9
Progressive ratio test 1 inactive lever presses0.10.40.40.6-0.6
Progressive ratio test 2 active lever presses0.10.10.20.3-0.4
Progressive ratio test 2 breakpoint0.20.30.40.5-0.6
Progressive ratio test 2 inactive lever presses0.00.00.0-0.20.1
Incentive Sensitization - Responses0.41.21.21.1-1.1
Incentive Sensitization - Breakpoint0.71.51.51.2-1.2
Sum of active levers in priming session hrs 5-60.20.20.20.4-0.4
Progressive ratio0.00.00.00.0-0.0
Food seeking constrained by brief footshock0.00.00.0-0.0-0.1
Seeking ratio, punishment vs. effort0.00.00.0-0.0-0.0
Retroperitoneal fat weight2.912.813.0-3.63.5
Reaction time number correct0.31.01.0-1.01.0
Reaction time mean minus median0.00.00.00.1-0.1
Reaction time mean minus median AUC0.00.20.20.4-0.4
Reaction time num false alarms0.40.70.7-0.80.8
Reaction time num false alarms AUC0.10.30.4-0.60.6
Reaction time trials correct on left0.31.01.0-1.01.0
Reaction time trials on left0.31.11.1-1.01.1
Reaction time mean0.10.30.30.5-0.5
Reaction time mean AUC0.10.30.40.6-0.6
Median of all reaction times0.20.20.30.5-0.5
Reaction time omissions0.40.60.7-0.80.8
Reaction time false alarm rate0.10.10.10.3-0.3
Reaction time premature initiation rate0.81.21.2-1.11.1
Reaction time premature initiations0.82.42.4-1.51.5
Std. dev. reaction times0.00.20.20.4-0.4
Reaction time trials completed0.31.11.1-1.01.1
Reaction time trials AUC0.20.70.8-0.80.9
Run reversals in cocaine runway, females0.00.00.0-0.10.2
Run reversals in cocaine runway, males1.11.21.21.1-1.1
Latency to leave start box in cocaine runway0.20.20.20.5-0.5
Latency to leave start box in cocaine runway, F0.10.20.20.4-0.4
Latency to leave start box in cocaine runway, M0.20.20.20.5-0.5
Std. dev. time between licks in bursts1.22.22.3-1.51.5
Total sessions with >9 infusions0.10.10.10.2-0.4
Short access day 1 total inactive lever presses0.00.00.0-0.20.1
Short access day 10 total inactive lever presses0.00.30.30.5-0.5
Short access day 1 total infusions0.00.00.0-0.20.1
Short access day 10 total infusions0.00.10.10.2-0.3
Short access total infusions0.00.10.1-0.30.2
Short access day 1 locomotion0.00.10.10.2-0.3
Short access day 10 total locomotion0.00.10.10.3-0.3
Short access total locomotion0.00.10.10.2-0.3
One hour access (0.3 mA shock)1.31.61.61.2-1.3
Compulsive drug intake1.01.51.61.2-1.3
One hour access (shock baseline)0.10.30.40.6-0.6
Social response proportion1.62.02.0-1.41.4
Social responses0.50.60.6-0.80.8
Social time1.01.61.7-1.21.3
Soleus weight0.00.00.00.1-0.0
Bone: stiffness3.05.45.52.3-2.3
Tibialis anterior weight11.138.338.86.2-6.2
Time to tail flick, vehicle, before self-admin0.10.10.20.4-0.4
Time to tail flick, vehicle, after self-admin0.20.30.40.6-0.5
Time to tail flick, test, before self-admin0.10.10.10.3-0.3
Time to tail flick, test, after self-admin0.70.80.90.9-0.8
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.10.2
Delta time to tail flick, test, before/after SA0.10.10.10.4-0.3
Tibia length0.00.10.10.3-0.3
Ambulatory time before self-admin0.00.10.1-0.40.3
Ambulatory time after self-admin1.11.81.8-1.41.3
Bone: tissue strength1.51.61.61.2-1.3
Total heroin consumption0.10.10.10.2-0.3
Bone: trabecular number0.00.10.1-0.30.3
Bone: trabecular spacing0.40.60.60.7-0.8
Bone: trabecular thickness0.10.20.20.4-0.4
Bone: trabecular tissue density1.83.23.21.8-1.8
Water consumed over 24 hours0.30.60.6-0.80.8
Number of responses in last shaping day0.40.50.6-0.60.7