Hub : Genes

Krt5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	intron excision ratio	chr7_132832634_132851232	0.45	0.19	2.1e-04	0.01	0.15	0.07	0.07	2.1e-01	2.5e-03	3.0e-02	3.4e-02
2	Eye	intron excision ratio	chr7_132850706_132851232	0.43	0.18	2.0e-04	0.04	0.15	0.08	0.08	7.2e-02	2.7e-03	2.4e-02	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.2	0.3	0.3	0.6	-0.5
Area under the delay curve	0.2	0.2	0.2	0.5	-0.5
BMI with tail	2.7	8.7	9.0	3.0	-2.9
BMI without tail	0.3	0.6	0.6	0.8	-0.7
Body weight	0.6	2.5	2.7	1.6	-1.5
Weight adjusted by age	0.1	0.1	0.2	0.4	-0.4
Bone surface	0.6	1.1	1.2	1.1	-1.0
Bone volume	0.7	1.2	1.3	1.1	-1.1
Breakpoint value in progressive ratio session	0.3	0.3	0.3	0.6	-0.6
Number of licking bursts	0.0	0.0	0.0	0.2	-0.2
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, session 1	5.6	6.1	6.2	-2.5	2.4
Locomotion distance, session 1	1.1	1.4	1.5	-1.2	1.2
Locomotion velocity, session 2	3.6	4.2	4.2	-2.0	2.0
Locomotion distance, session 2	1.4	1.9	2.0	-1.4	1.4
Locomotion velocity, session 3	5.9	6.9	6.9	-2.6	2.6
Locomotion distance, session 3	5.3	5.7	5.7	-2.4	2.4
Stereotopy head waving bouts, day 3	1.9	2.2	2.2	1.5	-1.5
Stereotopy head waving duration, day 3	0.0	0.1	0.1	0.2	-0.2
Locomotion velocity, session 7	1.2	1.3	1.4	-1.2	1.1
Locomotion distance, session 7	3.9	5.0	5.0	-2.2	2.2
Stereotopy head waving bouts, day 7	3.5	4.0	4.0	2.0	-2.0
Stereotopy head waving duration, day 7	3.3	4.0	4.0	2.0	-2.0
Locomotion velocity, session 8	0.1	0.1	0.1	-0.4	0.3
Locomotion distance, session 8	1.7	2.4	2.5	-1.6	1.5
Degree of sensitization distance	0.4	0.4	0.5	0.7	-0.7
Degree of sensitization stereotypy	3.2	3.5	3.5	1.9	-1.9
Conditioned locomotion	0.3	0.4	0.4	-0.6	0.6
Cocaine response after cond. corrected	0.0	0.0	0.0	0.1	-0.1
Cocaine response after cond. not corrected	0.0	0.0	0.0	-0.1	0.1
Cocaine response before conditioning	1.0	1.2	1.2	-1.1	1.1
Saline control response	0.0	0.0	0.0	-0.1	0.1
Bone: connectivity density	0.0	0.1	0.1	-0.2	0.3
Bone: cortical apparent density	0.9	1.2	1.2	1.1	-1.1
Bone: cortical area	0.9	1.3	1.4	1.2	-1.1
Bone: cortical porosity	1.5	1.6	1.6	-1.2	1.3
Bone: cortical porosity	1.4	1.5	1.6	-1.2	1.3
Bone: cortical thickness	0.2	0.3	0.3	0.5	-0.5
Bone: cortical thickness	0.8	0.9	0.9	-0.9	1.0
Bone: cortical tissue density	0.7	0.9	1.0	0.9	-1.0
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.4	-0.6	0.7
Condit. Reinf. active responses	0.7	0.9	0.9	-0.9	1.0
Condit. Reinf. inactive responses	0.9	1.0	1.1	-1.0	1.0
Incentive salience index mean	0.0	0.0	0.0	-0.1	0.1
Condit. Reinf. lever presses	0.6	0.8	0.8	0.9	-0.9
Condit. Reinf. active minus inactive responses	1.4	1.7	1.7	1.3	-1.3
Condit. Reinf. active-inactive response ratio	0.7	0.7	0.7	0.8	-0.8
Condit. Reinf. active responses	1.3	1.8	1.8	1.3	-1.3
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.4	-0.6	0.6
Condit. Reinf. lever reinforcers received	0.4	0.5	0.6	0.7	-0.7
Conditioned reinforcement - actives	0.2	0.2	0.3	0.4	-0.5
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.1	0.1
Conditioned locomotion	0.0	0.0	0.0	-0.2	0.1
Patch foraging indifference point 0 sec	0.3	0.5	0.6	-0.8	0.7
Patch foraging indifference point AUC	0.3	0.3	0.3	0.5	-0.6
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.2	-0.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.2	0.5	-0.4
Delay disc. indifference point, 2s delay	6.5	7.2	7.3	2.7	-2.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	0.4	-0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.2	0.5	-0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.2	0.3
Indifference point function ln k	0.0	0.0	0.0	0.2	-0.1
Indifference point function log k	0.0	0.0	0.0	0.2	-0.1
Patch foraging total patch changes 0 sec	0.9	1.4	1.4	-1.2	1.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.4	0.3
Patch foraging total patch changes 18 sec	0.4	0.5	0.6	-0.8	0.7
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	-0.0	-0.0
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.4	0.3
Patch foraging time to switch 0 sec	0.1	0.1	0.1	0.4	-0.4
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.0	0.0
Patch foraging water rate 12 sec	0.4	0.7	0.7	-0.8	0.8
Patch foraging water rate 18 sec	0.0	0.0	0.0	0.1	-0.1
Patch foraging water rate 24 sec	0.3	0.4	0.4	0.7	-0.7
Patch foraging water rate 6 sec	0.0	0.0	0.1	-0.2	0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.1	-0.1
Distance traveled before self-admin	0.0	0.0	0.0	0.0	-0.0
Distance traveled after self-admin	0.4	0.4	0.5	-0.7	0.7
Extensor digitorum longus weight	8.3	32.7	33.3	5.8	-5.7
Bone: elastic displacement	5.9	6.7	6.8	-2.6	2.6
Bone: elastic work	3.2	4.1	4.1	-2.0	2.0
Bone: endosteal estimation	0.7	1.4	1.5	1.2	-1.1
Bone: endosteal perimeter	1.3	2.7	2.8	1.7	-1.6
Epididymis fat weight	3.1	7.2	7.5	-2.7	2.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	-0.3
Delta time in open arm before/after self-admin	5.3	5.1	5.2	-2.3	2.3
Diff in mean of infusions in LGA sessions	1.0	1.1	1.1	1.1	-1.0
Delay discount exponential model param	0.3	0.4	0.4	-0.6	0.6
Extinction: sum of active levers before priming	1.2	1.2	1.3	1.1	-1.1
Active lever presses in extinction session 6	0.0	0.0	0.0	0.2	-0.2
Bone: final force	0.3	0.5	0.6	0.8	-0.7
Bone: final moment	0.3	0.5	0.6	0.8	-0.7
Food consumed during 24 hour testing period	0.4	0.5	0.6	-0.7	0.8
Glucose	0.1	0.2	0.2	-0.4	0.4
Heart weight	0.0	0.0	0.0	0.1	-0.1
Delay discount hyperbolic model param	0.7	0.8	0.8	-0.9	0.9
Intermittent access intake day 1-15 change	0.5	0.5	0.5	-0.7	0.7
Intermittent access intake escalation	0.3	0.3	0.4	-0.6	0.6
Intermittent access intake escalation 2	0.3	0.3	0.3	-0.5	0.5
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.5	0.6	0.6	-0.8	0.8
Intermitt. access escalation Index	1.3	1.1	1.2	1.0	-1.1
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.2
Intermittent access day 15 total infusions	0.2	0.2	0.2	-0.5	0.4
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.2	-0.3
Intermittent access total infusions	0.1	0.1	0.2	0.3	-0.4
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.5	0.4
Intermittent access day 15 total locomotion	0.9	1.0	1.0	-1.0	1.0
Intermittent access total locomotion	0.2	0.2	0.2	-0.5	0.4
Intermittent access standard deviation	1.0	1.1	1.1	-1.1	1.1
Left kidney weight	0.1	0.4	0.4	0.7	-0.6
Right kidney weight	0.5	1.3	1.4	1.2	-1.1
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	0.1
Post-drug Anxiety	0.7	0.8	0.9	0.9	-0.9
Baseline Anxiety	0.1	0.1	0.2	0.4	-0.4
Tail length	0.4	1.3	1.3	-1.2	1.1
Length with tail	0.1	0.3	0.3	-0.5	0.6
Length without tail	0.1	0.3	0.3	0.5	-0.5
Times rat made contact with spout	0.5	0.6	0.6	-0.7	0.8
Lifetime Intake	0.0	0.0	0.0	-0.0	-0.1
Liver weight, left	0.1	0.1	0.1	-0.3	0.3
Liver weight, right	0.1	0.1	0.1	-0.3	0.3
Locomotor activity	0.1	0.1	0.1	-0.3	0.3
Locomotor testing distance	0.8	1.3	1.3	-1.1	1.1
Locomotor testing rearing	0.5	0.8	0.8	-0.9	0.9
Locomotion in novel chamber	2.4	2.9	3.0	1.7	-1.7
Locomotion in novel chamber post-restriction	0.4	0.4	0.5	0.6	-0.7
Fecal boli incidents, locomotor time 1	4.2	4.6	4.6	-2.2	2.1
Change in fecal boli incidents, locomotor task	1.3	1.3	1.3	1.1	-1.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.5	-0.7	0.7
Bouts of movement, locomotor time 1	0.2	0.3	0.3	-0.5	0.5
Total resting periods, locomotor time 1	1.0	1.1	1.1	-1.0	1.0
Rest time, locomotor task time 1	0.7	0.8	0.8	-0.9	0.9
Distance moved, locomotor task time 1	1.1	1.2	1.2	1.1	-1.1
Vertical activity count, locomotor time 1	2.8	3.0	3.0	1.7	-1.7
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.3	-0.5	0.5
Bouts of movement, locomotor time 2	2.0	2.2	2.2	1.5	-1.5
Total resting periods, locomotor time 2	2.7	2.9	2.9	1.7	-1.7
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.3	0.2
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	-0.1
Vertical activity count, locomotor time 2	0.2	0.2	0.2	0.4	-0.4
Light reinforcement 1	0.0	0.0	0.0	-0.1	0.1
Light reinforcement 2	0.1	0.1	0.1	-0.3	0.3
Bone: marrow area	0.7	1.4	1.5	1.2	-1.1
Bone: maximum diameter	0.7	1.3	1.4	1.2	-1.1
Bone: maximum force	0.9	1.6	1.7	1.3	-1.2
Bone: maximum moment	0.9	1.6	1.7	1.3	-1.2
Mean time between licks in bursts	1.5	2.0	2.1	-1.5	1.4
Mean num. licks in bursts	0.8	0.9	1.0	-0.9	1.0
Cd content in liver	0.2	0.2	0.3	-0.5	0.5
Co content in liver	0.0	0.0	0.0	0.1	-0.1
Cu content in liver	1.0	1.2	1.2	1.1	-1.1
Fe content in liver	0.1	0.2	0.2	-0.4	0.4
K content in liver	0.2	0.2	0.2	-0.4	0.4
Mg content in liver	0.3	0.3	0.3	-0.6	0.5
Mn content in liver	0.0	0.0	0.0	-0.0	0.0
Na content in liver	0.0	0.0	0.0	0.0	-0.1
Rb content in liver	0.0	0.0	0.0	-0.2	0.2
Se content in liver	0.5	0.6	0.7	-0.8	0.8
Sr content in liver	1.5	1.4	1.4	-1.2	1.2
Zn content in liver	1.6	1.8	1.8	-1.4	1.3
Bone: minimum diameter	1.2	2.3	2.4	1.6	-1.5
Time in familiar zone, hab. session 1	0.6	0.6	0.6	-0.8	0.8
Time in novel zone, hab. session 1	2.5	2.5	2.5	1.6	-1.6
Total zone transitions, hab. session 1	0.3	0.4	0.4	0.6	-0.6
Total locomotion distance, hab. session 1	0.4	0.6	0.6	-0.8	0.7
Locomotion velocity, hab. session 1	0.5	0.8	0.8	-0.9	0.9
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.1	0.2
Time in novel zone, hab. session 2	0.4	0.4	0.5	0.6	-0.7
Total zone transitions, hab. session 2	0.3	0.4	0.4	-0.7	0.6
Total locomotion distance, hab. session 2	0.5	0.7	0.7	-0.8	0.8
Locomotion velocity, hab. session 2	0.8	1.1	1.1	-1.1	1.1
Novel to familiar place preference ratio	1.0	1.1	1.1	1.1	-1.0
Novelty place preference	0.7	0.7	0.7	0.9	-0.8
Time in novel zone, NPP test	0.9	0.9	0.9	1.0	-1.0
Total zone transitions, NPP test	0.9	1.3	1.4	-1.2	1.1
Total locomotion distance, NPP test	2.5	3.4	3.5	-1.9	1.8
Locomotion velocity, NPP test	2.9	4.1	4.1	-2.0	2.0
Intraocular pressure	0.5	0.7	0.8	-0.9	0.8
Delta distance traveled before/after self-admin	2.1	2.3	2.3	-1.5	1.5
Delta ambulatory time before/after self-admin	1.9	2.0	2.1	-1.4	1.4
Parametrial fat weight	3.7	7.1	7.2	-2.7	2.7
Pavlov. Cond. lever latency	1.8	2.3	2.3	-1.5	1.5
Pavlov. Cond. magazine entry latency	3.8	4.9	4.9	2.2	-2.2
Pavlov. Cond. change in total contacts	4.2	4.5	4.5	2.1	-2.1
Pavlov. Cond. index score	4.9	6.2	6.2	2.5	-2.5
Pavlov. Cond. latency score	4.5	5.8	5.8	2.4	-2.4
Pavlov. Cond. lever contacts	1.8	2.1	2.1	1.4	-1.5
Pavlov. Cond. magazine entry number	2.0	2.4	2.5	-1.6	1.6
Pavlov. Cond. intertrial magazine entries	2.4	3.0	3.0	-1.7	1.7
Pavlov. Cond. lever-magazine prob. diff.	4.8	6.0	6.0	2.4	-2.4
Pavlov. Cond. response bias	1.9	2.3	2.3	1.5	-1.5
Pavlov. Cond. lever latency	1.1	1.5	1.5	1.2	-1.2
Pavlov. Cond. magazine entry latency	2.9	3.3	3.4	-1.8	1.8
Pavlov. Cond. change in total contacts	1.0	1.4	1.4	1.2	-1.2
Pavlov. Cond. index score	1.7	2.2	2.3	-1.5	1.5
Pavlov. Cond. latency score	1.5	1.9	1.9	-1.4	1.4
Pavlov. Cond. lever contacts	2.0	2.8	2.8	-1.7	1.7
Pavlov. Cond. magazine entry number	0.7	0.9	0.9	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.2	-1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.4	-1.2	1.2
Pavlov. Cond. response bias	2.0	2.7	2.7	-1.6	1.6
Time in closed arm before self-admin	0.4	0.5	0.5	0.7	-0.7
Time in closed arm after self-admin	2.6	2.7	2.7	1.6	-1.6
Time in open arm before self-admin	2.8	3.0	3.1	1.7	-1.8
Time in open arm after self-admin	0.4	0.5	0.5	-0.7	0.7
Bone: periosteal estimation	1.0	2.1	2.3	1.5	-1.4
Bone: periosteal perimeter	2.6	4.3	4.4	2.1	-2.0
Bone: post-yield work	0.7	1.0	1.1	1.0	-1.0
Progressive ratio test 1 active lever presses	0.6	0.6	0.7	-0.8	0.7
Progressive ratio test 1 breakpoint	0.4	0.4	0.4	-0.7	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.1	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	-0.2	0.2
Incentive Sensitization - Responses	0.5	0.5	0.5	0.7	-0.7
Incentive Sensitization - Breakpoint	0.8	0.9	0.9	0.9	-0.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.5	-0.5
Progressive ratio	0.0	0.0	0.0	-0.1	0.1
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.1	-0.2
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.0	-0.1
Retroperitoneal fat weight	1.9	6.2	6.3	-2.5	2.5
Reaction time number correct	0.6	0.9	0.9	-0.9	1.0
Reaction time mean minus median	0.0	0.0	0.0	0.0	-0.0
Reaction time mean minus median AUC	0.1	0.1	0.1	0.3	-0.3
Reaction time num false alarms	0.3	0.4	0.4	-0.7	0.6
Reaction time num false alarms AUC	0.1	0.2	0.2	-0.4	0.4
Reaction time trials correct on left	0.6	0.9	0.9	-0.9	1.0
Reaction time trials on left	0.7	1.0	1.0	-1.0	1.0
Reaction time mean	0.1	0.2	0.2	0.4	-0.4
Reaction time mean AUC	0.2	0.2	0.2	0.5	-0.4
Median of all reaction times	0.1	0.2	0.2	0.4	-0.4
Reaction time omissions	1.0	1.3	1.4	-1.2	1.2
Reaction time false alarm rate	0.1	0.2	0.2	0.4	-0.5
Reaction time premature initiation rate	1.0	1.3	1.4	-1.2	1.1
Reaction time premature initiations	1.7	2.4	2.4	-1.5	1.6
Std. dev. reaction times	0.1	0.1	0.1	0.3	-0.3
Reaction time trials completed	0.7	1.0	1.0	-1.0	1.0
Reaction time trials AUC	0.5	0.7	0.7	-0.8	0.8
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.1	-0.1
Run reversals in cocaine runway, males	1.1	1.1	1.1	1.0	-1.0
Latency to leave start box in cocaine runway	0.3	0.4	0.4	0.6	-0.6
Latency to leave start box in cocaine runway, F	0.2	0.2	0.2	0.4	-0.5
Latency to leave start box in cocaine runway, M	0.7	0.6	0.7	0.8	-0.8
Std. dev. time between licks in bursts	1.9	2.3	2.3	-1.5	1.5
Total sessions with >9 infusions	0.4	0.5	0.6	0.7	-0.7
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.2	0.1
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.0	0.1
Short access day 1 total infusions	0.0	0.0	0.0	0.0	-0.0
Short access day 10 total infusions	0.0	0.0	0.0	-0.2	0.1
Short access total infusions	0.0	0.1	0.1	-0.3	0.2
Short access day 1 locomotion	0.0	0.0	0.0	-0.2	0.2
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	0.1
Short access total locomotion	0.0	0.0	0.0	-0.1	0.1
One hour access (0.3 mA shock)	2.5	2.9	2.9	1.7	-1.7
Compulsive drug intake	2.3	2.3	2.3	1.5	-1.5
One hour access (shock baseline)	0.9	1.1	1.1	1.0	-1.1
Social response proportion	1.5	1.6	1.6	-1.3	1.3
Social responses	0.5	0.6	0.6	-0.8	0.8
Social time	1.0	1.4	1.4	-1.1	1.2
Soleus weight	0.0	0.1	0.1	0.3	-0.2
Bone: stiffness	2.9	4.7	4.8	2.2	-2.1
Tibialis anterior weight	10.9	37.1	37.5	6.1	-6.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.3	0.5	-0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.4	-0.3
Time to tail flick, test, before self-admin	0.2	0.2	0.2	0.4	-0.4
Time to tail flick, test, after self-admin	0.3	0.3	0.4	0.6	-0.6
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.3	0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	0.4	-0.4
Tibia length	0.0	0.1	0.2	0.4	-0.3
Ambulatory time before self-admin	0.0	0.0	0.0	-0.2	0.1
Ambulatory time after self-admin	0.8	0.8	0.8	-0.9	0.9
Bone: tissue strength	1.5	1.5	1.5	1.2	-1.2
Total heroin consumption	0.0	0.0	0.0	0.2	-0.1
Bone: trabecular number	0.1	0.2	0.2	-0.4	0.5
Bone: trabecular spacing	0.6	0.7	0.8	0.8	-0.9
Bone: trabecular thickness	0.0	0.0	0.0	0.1	-0.1
Bone: trabecular tissue density	2.0	2.9	2.9	1.7	-1.7
Water consumed over 24 hours	0.7	0.8	0.8	-0.9	0.9
Number of responses in last shaping day	0.6	0.6	0.7	-0.8	0.8