Hub : Genes

Tnfrsf11b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Tnfrsf11b 0.31 0.17 8.4e-04 0.14 0.12 0.12 0.11 4.0e-04 1.0e-03 1.1e-03 1.2e-03
2 PL gene expression Tnfrsf11b 0.23 0.13 2.2e-16 0.07 0.05 0.11 0.1 7.1e-08 3.1e-06 3.1e-12 2.9e-11
3 IL gene expression Tnfrsf11b 0.27 0.16 2.3e-03 0.01 0.02 -0 0.02 1.4e-01 9.0e-02 3.4e-01 8.8e-02
4 BLA gene expression Tnfrsf11b 0.11 0.08 1.3e-04 0.07 0.01 0.07 0.04 1.2e-04 5.3e-02 1.6e-04 2.0e-03
5 Brain gene expression Tnfrsf11b 0.07 0.06 1.5e-04 0.01 0.02 0.02 0.02 4.6e-02 4.3e-03 7.2e-03 1.1e-02
6 Adipose gene expression Tnfrsf11b 0.21 0.12 0.0e+00 0.24 0.2 0.24 0.23 3.3e-26 5.4e-22 3.2e-26 3.0e-25
7 NAcc gene expression Tnfrsf11b 0.05 0.04 5.5e-04 0.03 0.03 0.03 0.03 8.0e-05 2.6e-04 3.3e-04 1.6e-04
8 Adipose mRNA stability Tnfrsf11b 0.03 0.02 3.1e-04 0.03 0.02 0.03 0.02 6.0e-04 1.7e-03 2.4e-04 2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.71.22.8-1.5-0.3-0.60.81.11.0-1.71.0
Area under the delay curve0.20.20.40.60.1-0.60.50.00.4-0.10.4
BMI with tail1.96.120.4-4.5-2.33.1-2.32.0-0.7-1.9-0.6
BMI without tail2.14.311.2-3.3-2.12.8-2.21.8-1.0-1.3-0.9
Body weight2.39.422.1-4.7-3.04.3-3.42.2-1.9-1.7-1.8
Weight adjusted by age0.40.41.1-1.10.50.8-0.4-0.90.20.7-0.0
Bone surface0.30.51.8-0.7-0.7-0.20.11.10.1-1.30.0
Bone volume0.50.82.4-0.9-0.4-0.70.81.10.7-1.50.7
Breakpoint value in progressive ratio session0.40.51.51.20.20.4-0.4-0.3-0.80.7-0.9
Number of licking bursts0.00.10.10.2-0.20.2-0.40.1-0.2-0.3-0.2
Context. condit. distance diff. score1.31.62.7-1.1-1.61.2-1.31.5-1.1-1.2-1.0
Locomotion velocity, session 10.10.10.30.10.3-0.30.5-0.20.50.00.5
Locomotion distance, session 10.00.00.00.1-0.10.10.2-0.00.2-0.10.1
Locomotion velocity, session 24.65.48.00.92.6-2.72.8-2.22.71.32.5
Locomotion distance, session 20.20.30.70.30.4-0.70.9-0.20.7-0.10.5
Locomotion velocity, session 32.02.34.5-1.3-1.91.2-1.12.1-1.1-1.9-1.1
Locomotion distance, session 33.53.87.5-0.7-2.71.6-1.52.7-1.8-2.0-1.9
Stereotopy head waving bouts, day 30.10.10.4-0.6-0.10.3-0.40.1-0.1-0.2-0.1
Stereotopy head waving duration, day 30.70.81.4-1.21.0-0.70.7-0.61.2-0.11.2
Locomotion velocity, session 70.40.41.3-1.2-0.50.5-0.40.80.0-1.00.0
Locomotion distance, session 73.03.85.9-1.5-2.42.0-2.12.3-1.6-1.8-1.5
Stereotopy head waving bouts, day 74.34.810.0-0.92.2-2.63.2-0.92.8-0.22.8
Stereotopy head waving duration, day 73.03.67.4-0.32.1-2.22.7-1.22.30.32.3
Locomotion velocity, session 80.00.00.1-0.10.20.4-0.1-0.30.00.2-0.0
Locomotion distance, session 81.72.54.6-0.9-2.21.4-1.32.1-1.3-1.7-1.3
Degree of sensitization distance0.20.20.4-0.50.50.3-0.5-0.60.20.50.3
Degree of sensitization stereotypy4.65.110.60.12.5-2.73.3-1.32.70.42.7
Conditioned locomotion0.20.20.5-0.0-0.30.7-0.5-0.1-0.60.3-0.5
Cocaine response after cond. corrected1.11.23.31.11.3-0.40.8-1.50.51.80.5
Cocaine response after cond. not corrected0.60.71.60.71.0-0.50.7-1.00.51.30.5
Cocaine response before conditioning0.80.92.8-0.8-1.30.1-0.31.5-0.2-1.7-0.3
Saline control response3.04.06.40.2-2.51.6-2.32.1-2.3-1.8-2.2
Bone: connectivity density0.10.20.4-0.5-0.0-0.40.50.40.5-0.70.5
Bone: cortical apparent density0.70.91.90.60.8-1.41.1-0.31.2-0.21.2
Bone: cortical area2.23.46.7-2.6-2.01.2-1.02.4-0.9-2.5-0.9
Bone: cortical porosity1.21.43.7-1.4-1.30.4-0.51.6-0.5-1.9-0.5
Bone: cortical porosity1.61.84.8-1.6-1.60.5-0.61.9-0.5-2.2-0.5
Bone: cortical thickness0.91.54.5-1.8-1.10.10.11.60.2-2.10.1
Bone: cortical thickness0.50.52.5-1.6-0.2-0.00.30.60.5-0.90.5
Bone: cortical tissue density0.70.91.90.60.9-1.41.1-0.41.2-0.11.2
Condit. Reinf. active minus inactive responses0.10.10.30.5-0.20.0-0.40.0-0.50.1-0.5
Condit. Reinf. active-inactive response ratio1.21.32.21.21.4-1.51.3-1.01.00.70.9
Condit. Reinf. active responses0.81.01.5-0.2-1.20.8-1.11.0-1.2-0.7-1.2
Condit. Reinf. inactive responses2.73.25.3-1.2-2.31.9-1.92.0-1.7-1.5-1.7
Incentive salience index mean0.50.71.10.0-1.00.5-0.90.9-0.9-0.7-1.0
Condit. Reinf. lever presses0.71.02.1-0.5-1.30.5-0.71.5-0.8-1.3-0.8
Condit. Reinf. active minus inactive responses0.50.62.6-1.6-0.70.7-0.10.8-0.2-0.8-0.2
Condit. Reinf. active-inactive response ratio0.50.63.0-1.7-0.31.1-0.30.3-0.20.0-0.2
Condit. Reinf. active responses1.42.05.9-2.4-1.41.1-0.61.7-0.5-1.7-0.5
Condit. Reinf. inactive responses0.81.02.6-1.0-1.20.3-0.51.6-0.5-1.6-0.5
Condit. Reinf. lever presses0.81.03.3-1.1-0.5-0.70.71.30.6-1.80.5
Condit. Reinf. lever reinforcers received1.62.25.7-2.4-1.50.9-0.52.0-0.5-2.1-0.5
Conditioned reinforcement - actives0.30.30.5-0.70.6-0.20.50.10.6-0.40.6
Conditioned reinforcement - inactives0.40.51.5-0.9-0.40.10.11.00.1-1.20.2
Conditioned locomotion0.50.61.5-0.9-0.41.2-0.90.7-0.6-0.5-0.6
Patch foraging indifference point 0 sec1.01.63.1-0.7-1.41.6-1.81.0-1.3-0.6-1.2
Patch foraging indifference point AUC2.22.53.9-0.5-2.01.5-1.91.8-1.7-0.9-1.7
Delay disc. indifference point, 0s delay0.40.41.50.80.30.3-0.5-0.8-0.11.2-0.1
Delay disc. indifference point, 16s delay1.01.01.80.60.8-1.31.2-0.81.20.51.1
Delay disc. indifference point, 2s delay0.50.51.20.50.2-1.10.90.30.8-0.70.8
Delay disc. indifference point, 24s delay0.40.40.60.4-0.70.5-0.60.6-0.8-0.2-0.8
Delay disc. indifference point, 4s delay0.00.00.20.0-0.2-0.10.10.40.1-0.40.1
Delay disc. indifference point, 8s delay0.50.50.90.7-0.90.5-0.80.6-0.8-0.2-0.8
Indifference point function ln k1.11.52.40.61.5-0.91.5-1.51.20.91.3
Indifference point function log k1.11.52.40.61.5-0.91.5-1.51.20.91.3
Patch foraging total patch changes 0 sec0.71.12.5-0.5-1.11.4-1.60.7-1.2-0.3-1.1
Patch foraging total patch changes 12 sec2.93.75.90.3-2.31.7-2.22.0-2.4-0.8-2.4
Patch foraging total patch changes 18 sec2.93.76.3-1.8-2.31.7-1.92.5-1.3-2.1-1.3
Patch foraging total patch changes 24 sec0.10.10.40.7-0.10.2-0.4-0.1-0.30.2-0.3
Patch foraging total patch changes 6 sec2.03.06.00.6-1.52.0-2.20.8-2.40.4-2.5
Patch foraging time to switch 0 sec1.21.83.21.81.7-1.11.0-1.70.61.70.3
Patch foraging water rate 0 sec0.50.83.4-1.8-0.80.9-0.80.6-0.1-0.6-0.1
Patch foraging water rate 12 sec0.20.31.0-1.0-0.30.1-0.20.30.5-1.00.5
Patch foraging water rate 18 sec0.20.30.7-0.4-0.80.5-0.20.5-0.5-0.8-0.4
Patch foraging water rate 24 sec0.10.10.40.30.20.20.1-0.5-0.20.7-0.2
Patch foraging water rate 6 sec1.21.85.9-2.4-1.00.2-0.11.60.5-2.10.6
Seeking ratio, delayed vs. immediate footshock0.10.10.20.20.3-0.00.3-0.40.10.40.0
Distance traveled before self-admin1.71.82.9-1.1-1.71.4-1.51.4-1.2-1.1-1.2
Distance traveled after self-admin0.10.10.50.1-0.20.5-0.7-0.1-0.20.2-0.3
Extensor digitorum longus weight2.18.327.8-5.3-2.73.1-2.22.7-0.9-2.8-1.0
Bone: elastic displacement2.93.36.4-1.11.5-2.02.4-0.62.5-0.72.5
Bone: elastic work1.72.24.0-2.00.5-1.21.60.31.8-1.51.8
Bone: endosteal estimation1.53.35.7-0.8-1.82.4-2.31.2-2.3-0.3-2.2
Bone: endosteal perimeter1.43.03.7-1.6-1.91.9-1.91.8-1.7-1.3-1.7
Epididymis fat weight2.45.712.22.0-1.62.5-2.60.3-3.51.2-3.5
Delta time in closed arm before/after self-admin0.80.81.50.61.1-1.20.7-0.91.00.60.8
Delta time in open arm before/after self-admin0.40.41.50.10.30.4-0.1-1.0-0.21.2-0.3
Diff in mean of infusions in LGA sessions0.40.50.80.40.9-0.20.9-0.90.40.90.4
Delay discount exponential model param0.20.20.6-0.7-0.10.7-0.5-0.1-0.40.1-0.3
Extinction: sum of active levers before priming0.30.31.71.3-0.1-0.40.20.0-0.60.3-0.6
Active lever presses in extinction session 60.10.10.30.3-0.1-0.20.40.5-0.2-0.5-0.3
Bone: final force1.42.33.1-1.4-1.81.6-1.41.7-1.5-1.4-1.5
Bone: final moment0.91.41.9-1.3-1.41.2-1.01.4-1.0-1.2-1.1
Food consumed during 24 hour testing period1.11.42.51.3-0.61.3-1.1-0.2-1.61.0-1.6
Glucose0.81.24.42.10.9-1.00.8-1.20.11.30.0
Heart weight1.62.23.4-1.70.4-1.61.60.71.7-1.81.8
Delay discount hyperbolic model param0.20.20.5-0.6-0.00.7-0.5-0.1-0.40.2-0.4
Intermittent access intake day 1-15 change2.12.13.60.21.7-1.81.9-0.91.70.31.7
Intermittent access intake escalation1.71.62.70.21.5-1.61.6-1.01.50.41.4
Intermittent access intake escalation 22.02.03.8-0.71.4-1.51.7-0.61.9-0.22.0
Intermitt. access day 1 inactive lever presses0.50.61.20.4-0.60.7-0.90.5-1.10.0-1.0
Intermitt. access day 15 inactive lever presses0.20.30.6-0.8-0.50.1-0.00.60.2-0.80.3
Intermitt. access escalation Index2.22.05.92.00.70.3-0.5-1.8-0.82.4-1.0
Intermittent access day 1 total infusions0.20.20.50.20.6-0.60.70.10.3-0.30.3
Intermittent access day 15 total infusions1.71.93.60.61.9-1.61.6-1.41.40.91.2
Intermittent access terminal intake (last 3 days)0.80.91.8-0.21.2-1.21.3-0.31.1-0.21.0
Intermittent access total infusions0.91.02.0-0.11.2-1.31.4-0.21.1-0.31.1
Intermittent access day 1 locomotion0.30.30.8-0.20.9-0.20.5-0.50.70.30.6
Intermittent access day 15 total locomotion0.50.51.3-1.10.80.50.1-0.80.80.60.6
Intermittent access total locomotion0.60.72.9-1.70.50.20.40.11.0-0.61.0
Intermittent access standard deviation1.11.22.4-0.61.1-1.31.6-0.21.4-0.51.4
Left kidney weight0.20.51.4-0.50.21.2-0.8-0.8-0.20.8-0.2
Right kidney weight0.30.71.7-0.90.41.3-0.5-1.10.01.3-0.0
Cocaine induced anxiety0.20.20.80.90.5-0.30.1-0.5-0.00.7-0.1
Post-drug Anxiety2.02.34.1-0.11.4-1.91.9-0.92.00.12.0
Baseline Anxiety0.91.03.6-1.9-0.70.10.20.90.6-1.40.7
Tail length0.31.01.7-1.0-1.01.3-1.00.9-1.0-0.3-1.0
Length with tail0.62.25.5-1.3-1.32.3-1.90.4-1.60.1-1.6
Length without tail0.41.02.5-1.3-0.81.6-1.10.2-0.9-0.1-0.8
Times rat made contact with spout2.02.34.21.9-1.60.7-1.41.2-2.0-0.4-2.0
Lifetime Intake0.60.71.60.01.0-1.21.3-0.00.8-0.40.7
Liver weight, left0.20.41.4-0.00.30.7-0.5-0.9-0.21.2-0.1
Liver weight, right1.11.94.0-2.0-1.41.4-1.01.5-0.9-1.5-0.8
Locomotor activity1.21.94.4-1.8-1.60.7-0.71.8-0.5-2.1-0.4
Locomotor testing distance0.40.72.5-0.9-0.80.1-0.31.20.0-1.60.0
Locomotor testing rearing0.60.91.90.0-1.20.9-0.91.4-1.0-0.7-0.9
Locomotion in novel chamber0.70.82.8-1.7-0.30.00.31.00.7-1.30.6
Locomotion in novel chamber post-restriction0.70.82.00.3-1.00.3-0.41.4-1.1-1.0-1.0
Fecal boli incidents, locomotor time 10.40.41.40.70.40.0-0.3-1.20.11.20.1
Change in fecal boli incidents, locomotor task0.10.10.2-0.4-0.1-0.10.30.4-0.1-0.3-0.0
Time >=10cm from walls, locomotor time 10.80.81.2-0.6-1.11.1-1.10.8-0.8-0.6-0.8
Bouts of movement, locomotor time 10.50.51.4-0.30.6-0.40.7-0.41.2-0.21.2
Total resting periods, locomotor time 10.80.91.9-0.20.9-0.91.1-0.61.40.01.4
Rest time, locomotor task time 10.60.63.01.70.4-1.10.6-0.2-0.10.30.0
Distance moved, locomotor task time 10.60.72.4-1.50.3-0.20.60.11.1-0.71.0
Vertical activity count, locomotor time 10.20.20.9-0.90.10.50.10.30.1-0.40.0
Time >=10cm from walls, locomotor time 21.61.73.4-0.1-1.21.8-1.80.5-1.60.1-1.7
Bouts of movement, locomotor time 20.10.10.40.60.10.0-0.1-0.2-0.10.3-0.1
Total resting periods, locomotor time 20.10.10.60.70.10.1-0.0-0.2-0.20.3-0.1
Rest time, locomotor task time 20.30.41.81.30.4-0.80.70.0-0.00.10.0
Distance moved, locomotor task time 20.60.73.9-2.00.10.10.3-0.10.9-0.40.9
Vertical activity count, locomotor time 20.80.92.4-1.4-0.41.6-1.1-0.2-0.60.5-0.6
Light reinforcement 10.10.10.70.80.1-0.1-0.0-0.2-0.30.3-0.4
Light reinforcement 20.50.62.21.5-0.30.1-0.60.1-0.90.5-0.9
Bone: marrow area1.63.56.0-0.8-1.92.5-2.31.2-2.4-0.3-2.3
Bone: maximum diameter2.34.25.4-1.5-2.32.3-2.22.1-2.2-1.4-2.2
Bone: maximum force2.54.35.7-2.3-2.42.0-1.82.4-1.7-2.0-1.7
Bone: maximum moment1.83.14.8-2.2-2.01.6-1.42.1-1.3-1.9-1.3
Mean time between licks in bursts0.71.02.0-0.70.8-1.01.4-0.41.4-0.21.4
Mean num. licks in bursts0.20.20.50.7-0.40.1-0.00.4-0.60.1-0.6
Cd content in liver1.41.52.50.41.4-1.61.5-1.11.40.61.4
Co content in liver0.50.61.2-0.90.6-0.60.7-0.21.1-0.21.1
Cu content in liver2.02.46.32.51.5-0.90.8-1.90.42.20.5
Fe content in liver1.01.23.41.80.30.6-0.6-0.9-1.01.8-0.9
K content in liver3.13.15.51.7-0.91.9-2.0-0.4-2.31.6-2.3
Mg content in liver0.90.91.91.4-0.50.8-1.1-0.1-1.20.8-1.2
Mn content in liver0.10.10.30.60.1-0.10.0-0.2-0.00.3-0.1
Na content in liver3.53.78.42.90.11.4-1.3-1.3-2.12.7-2.1
Rb content in liver0.81.02.91.30.30.7-0.7-1.1-0.81.7-0.9
Se content in liver0.10.20.50.7-0.3-0.40.10.6-0.1-0.5-0.1
Sr content in liver0.50.41.3-0.9-0.11.1-1.0-0.1-0.30.2-0.3
Zn content in liver1.01.12.40.7-0.91.2-1.50.3-1.30.2-1.3
Bone: minimum diameter3.87.29.7-2.8-3.12.7-2.63.0-2.3-2.5-2.3
Time in familiar zone, hab. session 10.20.20.4-0.3-0.40.7-0.60.3-0.4-0.2-0.5
Time in novel zone, hab. session 10.50.41.11.10.7-0.20.3-0.8-0.01.10.0
Total zone transitions, hab. session 10.50.73.0-1.70.00.00.20.50.8-0.90.9
Total locomotion distance, hab. session 10.40.62.0-1.4-0.71.0-0.70.6-0.3-0.6-0.3
Locomotion velocity, hab. session 10.50.72.3-1.5-0.80.8-0.40.9-0.0-0.90.0
Time in familiar zone, hab. session 20.10.10.30.00.4-0.50.3-0.20.5-0.00.4
Time in novel zone, hab. session 20.10.10.4-0.6-0.20.6-0.30.0-0.20.0-0.2
Total zone transitions, hab. session 20.20.30.50.1-0.70.5-0.40.7-0.5-0.5-0.5
Total locomotion distance, hab. session 20.10.20.30.3-0.60.5-0.40.4-0.5-0.1-0.5
Locomotion velocity, hab. session 20.10.10.30.6-0.30.3-0.20.2-0.40.1-0.4
Novel to familiar place preference ratio0.60.61.00.20.9-0.60.8-1.00.80.90.8
Novelty place preference1.11.11.50.21.2-0.91.2-1.21.20.91.2
Time in novel zone, NPP test1.01.11.50.01.2-0.91.1-1.11.20.81.2
Total zone transitions, NPP test1.72.54.5-1.8-1.91.2-1.12.1-0.8-2.1-0.8
Total locomotion distance, NPP test1.21.72.7-1.4-1.61.3-1.21.6-0.9-1.4-0.9
Locomotion velocity, NPP test1.31.83.0-1.4-1.71.3-1.21.7-0.9-1.5-0.9
Intraocular pressure0.30.41.9-1.4-0.40.9-0.50.3-0.1-0.2-0.1
Delta distance traveled before/after self-admin0.20.20.40.50.50.10.0-0.60.30.60.3
Delta ambulatory time before/after self-admin0.20.20.50.40.6-0.00.1-0.70.40.70.4
Parametrial fat weight1.83.58.1-0.5-1.92.9-2.40.8-2.1-0.2-2.2
Pavlov. Cond. lever latency1.11.42.4-0.11.5-1.01.3-1.21.50.71.4
Pavlov. Cond. magazine entry latency0.40.61.10.1-1.10.3-0.71.0-0.8-0.8-0.7
Pavlov. Cond. change in total contacts0.20.20.30.6-0.5-0.40.00.6-0.3-0.5-0.2
Pavlov. Cond. index score1.01.22.5-0.2-1.60.5-0.91.6-1.1-1.3-1.0
Pavlov. Cond. latency score1.21.52.8-0.1-1.70.7-1.11.6-1.3-1.2-1.2
Pavlov. Cond. lever contacts1.82.13.5-0.1-1.91.2-1.61.6-1.7-1.1-1.7
Pavlov. Cond. magazine entry number0.70.82.0-0.01.3-0.10.5-1.40.81.20.7
Pavlov. Cond. intertrial magazine entries0.70.81.50.3-0.41.2-1.2-0.4-1.10.9-1.2
Pavlov. Cond. lever-magazine prob. diff.1.21.52.80.1-1.70.7-1.21.5-1.4-1.1-1.3
Pavlov. Cond. response bias0.60.71.7-0.1-1.20.2-0.61.3-0.8-1.1-0.7
Pavlov. Cond. lever latency0.40.61.70.20.90.20.1-1.20.51.30.5
Pavlov. Cond. magazine entry latency0.70.82.2-0.4-1.1-0.0-0.71.3-0.4-1.5-0.5
Pavlov. Cond. change in total contacts1.31.75.2-2.0-1.2-0.20.11.90.1-2.30.0
Pavlov. Cond. index score1.01.32.8-0.4-1.50.3-0.81.7-0.9-1.7-0.9
Pavlov. Cond. latency score0.81.02.7-0.4-1.30.1-0.61.5-0.7-1.6-0.8
Pavlov. Cond. lever contacts0.50.72.00.1-0.9-0.40.01.4-0.4-1.4-0.5
Pavlov. Cond. magazine entry number1.31.63.21.01.6-0.61.1-1.80.91.80.9
Pavlov. Cond. intertrial magazine entries1.21.65.30.90.41.3-1.0-1.5-1.02.3-0.9
Pavlov. Cond. lever-magazine prob. diff.1.11.32.5-0.4-1.50.4-1.01.6-1.0-1.5-1.1
Pavlov. Cond. response bias0.91.23.7-0.7-1.3-0.2-0.31.8-0.4-1.9-0.5
Time in closed arm before self-admin0.91.11.90.2-0.81.4-1.3-0.1-1.40.8-1.3
Time in closed arm after self-admin1.21.22.31.31.3-1.00.5-1.50.61.50.4
Time in open arm before self-admin0.40.51.4-0.8-0.0-0.30.40.80.7-1.20.7
Time in open arm after self-admin0.20.20.60.00.00.6-0.3-0.5-0.30.8-0.5
Bone: periosteal estimation2.04.15.4-1.9-2.32.2-2.12.1-2.0-1.5-2.0
Bone: periosteal perimeter2.94.86.8-1.9-2.62.1-2.22.5-2.0-2.0-2.0
Bone: post-yield work2.43.36.4-0.4-1.82.5-2.40.9-2.30.1-2.2
Progressive ratio test 1 active lever presses0.40.51.10.21.1-0.81.0-0.50.60.30.5
Progressive ratio test 1 breakpoint0.50.61.20.11.1-0.91.1-0.40.70.10.6
Progressive ratio test 1 inactive lever presses0.20.30.70.60.6-0.80.7-0.20.20.10.2
Progressive ratio test 2 active lever presses0.50.61.1-0.70.9-0.50.8-0.61.10.11.0
Progressive ratio test 2 breakpoint0.91.01.9-0.51.3-0.91.2-0.81.40.31.3
Progressive ratio test 2 inactive lever presses0.50.51.1-1.00.1-0.40.70.60.8-1.00.8
Incentive Sensitization - Responses0.90.92.8-1.4-0.90.10.11.30.2-1.70.4
Incentive Sensitization - Breakpoint0.60.61.6-1.2-0.60.00.20.90.4-1.30.5
Sum of active levers in priming session hrs 5-61.01.02.1-1.4-1.10.6-0.21.3-0.3-1.5-0.1
Progressive ratio2.52.86.3-0.91.0-1.81.9-0.12.4-1.32.5
Food seeking constrained by brief footshock0.91.11.80.1-1.20.7-1.41.3-1.2-1.0-1.1
Seeking ratio, punishment vs. effort2.83.47.30.8-1.51.9-2.30.9-2.70.5-2.7
Retroperitoneal fat weight0.62.13.1-1.2-1.81.6-1.31.6-1.4-1.4-1.3
Reaction time number correct0.40.61.30.0-0.41.1-1.1-0.2-0.90.5-0.9
Reaction time mean minus median1.82.34.0-0.1-1.62.0-2.00.6-1.9-0.3-1.9
Reaction time mean minus median AUC0.20.20.50.2-0.30.7-0.6-0.3-0.60.1-0.7
Reaction time num false alarms1.01.42.4-0.3-1.61.0-1.31.6-1.2-1.1-1.0
Reaction time num false alarms AUC1.11.52.6-0.4-1.61.1-1.41.6-1.1-1.2-1.0
Reaction time trials correct on left0.40.61.30.0-0.41.1-1.1-0.2-0.90.5-0.9
Reaction time trials on left0.50.71.50.0-0.61.2-1.2-0.2-1.00.5-1.0
Reaction time mean1.21.72.8-0.7-1.41.7-1.51.0-1.4-0.8-1.5
Reaction time mean AUC1.21.62.5-0.5-1.41.6-1.41.0-1.4-0.8-1.5
Median of all reaction times0.70.91.3-0.5-1.01.1-1.00.9-1.0-0.7-1.1
Reaction time omissions0.30.41.00.4-0.70.8-0.30.3-0.9-0.3-1.0
Reaction time false alarm rate0.71.02.9-0.9-1.10.1-0.41.7-0.1-1.70.0
Reaction time premature initiation rate0.70.92.8-0.6-1.10.3-0.61.6-0.2-1.7-0.0
Reaction time premature initiations0.50.71.3-0.2-1.10.7-1.01.1-0.6-1.0-0.5
Std. dev. reaction times1.92.74.8-0.3-1.82.2-2.00.9-2.0-0.5-2.1
Reaction time trials completed0.50.71.50.0-0.61.2-1.2-0.2-1.00.5-1.0
Reaction time trials AUC0.40.51.2-0.1-0.51.1-1.1-0.2-0.80.4-0.9
Run reversals in cocaine runway, females0.30.30.91.00.4-0.70.7-0.10.30.10.3
Run reversals in cocaine runway, males0.40.40.9-0.7-0.50.9-0.7-0.0-0.60.3-0.6
Latency to leave start box in cocaine runway5.76.29.42.73.0-3.12.4-2.71.72.41.5
Latency to leave start box in cocaine runway, F6.57.111.73.43.1-2.82.2-3.21.13.21.0
Latency to leave start box in cocaine runway, M1.01.02.3-0.30.7-1.51.20.11.3-0.51.2
Std. dev. time between licks in bursts0.70.81.40.21.0-1.11.2-0.61.10.31.1
Total sessions with >9 infusions0.20.30.90.90.6-0.30.2-0.1-0.50.3-0.6
Short access day 1 total inactive lever presses0.60.71.4-0.7-0.80.6-0.61.2-0.7-1.1-0.7
Short access day 10 total inactive lever presses0.91.02.00.2-1.00.9-1.10.9-1.4-0.4-1.3
Short access day 1 total infusions0.70.82.00.4-0.50.3-0.51.1-1.4-0.6-1.4
Short access day 10 total infusions0.20.20.7-0.30.2-0.40.50.70.2-0.80.1
Short access total infusions0.20.30.70.40.4-0.90.70.5-0.1-0.6-0.1
Short access day 1 locomotion0.10.10.4-0.40.60.6-0.2-0.2-0.10.2-0.2
Short access day 10 total locomotion0.10.10.2-0.00.30.5-0.2-0.1-0.30.2-0.3
Short access total locomotion0.10.10.2-0.50.10.5-0.20.4-0.3-0.3-0.3
One hour access (0.3 mA shock)0.60.82.2-1.50.5-0.20.70.11.2-0.71.2
Compulsive drug intake0.60.61.20.10.3-0.60.5-1.11.10.71.1
One hour access (shock baseline)0.30.31.0-1.00.10.20.10.90.1-1.00.1
Social response proportion0.70.83.7-1.9-0.30.30.10.70.5-1.00.6
Social responses1.62.07.8-2.8-0.70.20.31.40.8-2.10.8
Social time0.20.20.7-0.9-0.40.4-0.20.6-0.0-0.60.1
Soleus weight1.23.55.9-2.4-2.02.3-2.01.8-1.4-1.4-1.4
Bone: stiffness1.62.53.5-1.0-1.91.6-1.61.8-1.7-1.2-1.7
Tibialis anterior weight2.17.327.0-5.2-2.31.9-1.12.9-0.2-3.5-0.3
Time to tail flick, vehicle, before self-admin0.50.52.10.50.70.30.3-1.2-0.21.4-0.2
Time to tail flick, vehicle, after self-admin4.14.48.90.4-2.12.2-2.21.9-3.0-0.8-2.8
Time to tail flick, test, before self-admin1.31.32.00.0-1.41.2-1.31.1-1.4-0.5-1.3
Time to tail flick, test, after self-admin0.80.81.40.2-1.10.3-0.91.2-1.1-0.9-0.9
Delta time to tail flick, vehicle, before/after SA4.24.28.2-0.7-2.41.3-1.92.9-2.1-2.4-1.9
Delta time to tail flick, test, before/after SA0.40.30.9-0.6-0.60.1-0.30.9-0.4-0.9-0.2
Tibia length1.54.27.6-2.8-2.02.7-2.11.7-1.9-0.7-1.8
Ambulatory time before self-admin1.31.32.2-0.8-1.51.3-1.41.2-1.1-0.5-1.1
Ambulatory time after self-admin0.20.20.5-0.2-0.50.7-0.70.2-0.5-0.0-0.5
Bone: tissue strength0.20.20.30.00.4-0.50.4-0.30.5-0.00.5
Total heroin consumption1.11.33.41.2-0.71.1-1.10.2-1.70.4-1.8
Bone: trabecular number1.21.92.9-1.6-0.0-1.31.51.01.5-1.71.5
Bone: trabecular spacing0.71.03.11.30.90.3-0.0-1.4-0.21.8-0.2
Bone: trabecular thickness0.70.81.5-1.20.1-0.70.90.61.1-1.11.1
Bone: trabecular tissue density1.41.96.32.51.3-0.90.5-1.60.21.90.3
Water consumed over 24 hours3.64.47.20.9-2.51.9-2.21.9-2.7-1.2-2.7
Number of responses in last shaping day1.01.03.21.80.20.3-0.6-0.3-1.31.0-1.4