Hub : Genes

Ccs

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Ccs 0.05 0.04 3.3e-04 0.03 0.02 0.03 0.02 2.0e-03 5.7e-03 1.6e-03 3.0e-03
2 LHb alternative TSS XM_039092800.2 0.15 0.1 3.5e-03 0.05 0.08 0.04 0.06 2.9e-02 6.2e-03 4.1e-02 1.8e-02
3 LHb alternative TSS NM_053425.1 0.15 0.1 4.0e-03 0.06 0.08 0.04 0.06 1.5e-02 6.7e-03 4.8e-02 1.6e-02
4 Liver mRNA stability Ccs 0.04 0.03 1.4e-03 0.02 0.01 0.01 0.02 1.1e-03 1.0e-02 4.5e-02 4.6e-03
5 IL gene expression Ccs 0.61 0.17 2.1e-10 0.28 0.12 0.24 0.03 1.7e-07 9.7e-04 1.8e-06 5.2e-02
6 LHb gene expression Ccs 0.35 0.15 2.4e-06 0.26 0.22 0.21 0.23 7.8e-07 5.3e-06 1.2e-05 3.8e-06
7 Liver gene expression Ccs 0.06 0.04 9.4e-06 0.03 0.03 0.03 0.02 2.2e-04 2.6e-04 8.3e-04 1.0e-03
8 OFC gene expression Ccs 0.62 0.14 2.9e-09 0.27 0.07 0.25 0.01 4.2e-07 8.2e-03 1.5e-06 2.1e-01
9 NAcc gene expression Ccs 0.4 0.12 0.0e+00 0.39 0.4 0.39 0.4 4.5e-63 4.2e-64 8.3e-63 3.1e-64
10 Liver intron excision ratio chr1_211543488_211543586 0.03 0.02 3.3e-03 0.01 -0 -0 0 2.8e-02 4.2e-01 6.1e-01 2.0e-01
11 IC gene expression Ccs 0.4 0.15 1.1e-16 0.34 0.36 0.33 0.36 3.8e-15 4.0e-16 1.6e-14 8.2e-16
12 BLA gene expression Ccs 0.61 0.1 0.0e+00 0.41 0.44 0.44 0.43 2.7e-23 1.4e-25 2.9e-25 7.7e-25
13 pVTA gene expression Ccs 0.44 0.14 0.0e+00 0.43 0.46 0.45 0.46 1.3e-37 1.7e-40 6.1e-40 2.3e-40
14 PL gene expression Ccs 0.4 0.13 0.0e+00 0.42 0.43 0.43 0.43 4.5e-49 1.5e-51 7.9e-51 5.5e-51
15 Brain gene expression Ccs 0.33 0.06 0.0e+00 0.42 0.44 0.44 0.44 8.1e-42 1.3e-44 2.7e-45 1.6e-45
16 Liver alternative polyA NM_053425.1 0.18 0.09 2.5e-14 0.1 0.11 0.1 0.11 3.9e-11 6.3e-12 6.4e-11 3.8e-12
17 NAcc isoform ratio NM_053425.1 0.03 0.02 5.5e-04 0.02 0.01 0.02 0.01 1.1e-03 6.8e-03 1.5e-03 2.3e-03
18 NAcc isoform ratio XM_039092800.2 0.03 0.02 8.0e-04 0.02 0.01 0.01 0.01 1.3e-03 9.5e-03 1.9e-03 2.8e-03
19 Liver alternative polyA XM_039092800.2 0.17 0.08 3.2e-14 0.1 0.11 0.1 0.11 4.6e-11 2.6e-12 2.0e-11 2.0e-12
20 BLA intron excision ratio chr1_211543837_211555856 0.06 0.05 5.3e-03 0.01 0.01 -0 0 7.2e-02 8.3e-02 7.9e-01 1.6e-01
21 BLA intron excision ratio chr1_211555916_211556368 0.07 0.06 4.5e-03 0.03 0.01 -0 0.01 1.5e-02 9.7e-02 7.1e-01 1.0e-01
22 RMTg gene expression Ccs 0.35 0.14 2.6e-08 0.16 0.28 0.25 0.25 6.2e-05 3.4e-08 2.9e-07 2.3e-07
23 Eye isoform ratio NM_053425.1 0.63 0.3 7.8e-03 -0.01 -0.02 0.08 -0.02 6.2e-01 6.5e-01 2.5e-02 7.0e-01
24 Eye isoform ratio XM_039092800.2 0.73 0.22 8.3e-03 -0 -0.02 0.08 -0.02 3.9e-01 7.9e-01 2.5e-02 9.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bone: apparent density1.83.27.4-0.50.8-0.9-1.41.51.51.41.31.71.01.61.91.71.71.81.82.2-2.7-1.82.7-2.72.51.7-1.5
Area under the delay curve1.11.34.8-1.10.8-0.9-0.91.01.00.71.21.10.51.00.81.01.01.11.00.5-1.1-1.01.1-1.11.02.2-2.1
BMI with tail1.86.222.10.60.2-0.3-1.21.31.31.21.11.70.71.72.01.81.92.12.43.7-4.7-2.54.5-4.53.63.0-3.0
BMI without tail0.72.211.90.9-0.20.1-0.10.30.30.20.40.5-0.00.70.60.70.80.81.12.0-3.4-1.12.9-2.92.02.3-2.2
Body weight0.72.99.22.8-2.22.11.4-1.4-1.4-1.6-1.3-1.0-1.9-0.9-0.6-0.9-0.8-0.7-0.42.1-3.00.32.7-2.71.21.4-1.6
Weight adjusted by age0.81.22.51.5-1.61.61.3-1.2-1.2-1.3-1.5-1.1-1.4-1.2-0.9-1.2-1.1-1.1-1.10.5-0.31.00.1-0.1-0.4-1.00.9
Bone surface1.32.310.21.3-0.80.7-0.40.40.40.10.40.8-0.20.51.30.60.71.21.13.2-3.0-1.22.9-2.92.31.1-1.2
Bone volume1.22.26.30.10.1-0.2-1.11.11.10.80.91.30.51.11.71.21.21.51.42.5-2.4-1.52.5-2.52.31.1-1.0
Breakpoint value in progressive ratio session0.80.92.41.6-1.51.51.1-0.9-0.9-0.9-1.1-0.7-1.0-0.9-0.3-0.8-0.7-0.5-0.61.3-1.00.60.9-0.90.3-0.90.8
Number of licking bursts0.00.10.3-0.0-0.40.4-0.00.00.0-0.30.00.1-0.2-0.10.1-0.1-0.10.2-0.10.50.00.00.3-0.30.30.3-0.3
Context. condit. distance diff. score0.50.72.2-1.51.3-1.2-0.80.90.91.10.60.71.20.80.50.80.80.40.5-0.30.2-0.5-0.50.50.0-0.80.7
Locomotion velocity, session 10.40.40.9-0.1-0.50.50.5-0.5-0.5-0.8-0.5-0.6-0.9-0.6-0.9-0.7-0.7-0.6-0.7-0.70.60.7-0.50.5-0.80.00.0
Locomotion distance, session 10.91.13.6-0.40.2-0.3-0.80.70.70.40.80.80.10.80.80.80.80.90.91.2-1.7-0.91.9-1.91.41.7-1.7
Locomotion velocity, session 20.70.81.91.4-1.31.20.8-0.9-0.9-1.0-0.9-0.7-1.2-0.7-0.6-0.7-0.6-0.6-0.40.7-1.30.31.4-1.40.40.6-0.7
Locomotion distance, session 20.50.72.70.3-0.30.2-0.10.00.0-0.20.30.1-0.60.20.10.20.20.20.40.8-1.6-0.41.6-1.60.91.6-1.7
Locomotion velocity, session 30.50.61.2-0.70.7-0.7-0.80.80.80.70.70.80.60.80.70.80.80.70.90.8-0.3-0.90.7-0.70.81.0-1.1
Locomotion distance, session 30.00.00.1-0.20.1-0.1-0.10.10.10.0-0.10.1-0.10.10.00.10.1-0.10.10.10.3-0.2-0.10.10.00.4-0.4
Stereotopy head waving bouts, day 30.80.91.5-1.01.2-1.2-0.80.90.91.11.00.81.01.10.71.01.00.71.10.1-0.8-1.10.8-0.80.81.2-1.1
Stereotopy head waving duration, day 31.11.32.1-1.21.4-1.4-1.11.21.21.41.41.21.41.31.01.31.31.01.20.2-0.5-1.20.6-0.60.91.1-1.0
Locomotion velocity, session 70.80.92.8-0.50.9-0.9-0.80.80.81.10.80.91.11.00.81.01.00.91.00.8-1.7-1.01.0-1.01.10.2-0.1
Locomotion distance, session 70.10.11.60.20.0-0.10.1-0.1-0.10.1-0.1-0.1-0.00.2-0.20.10.1-0.10.20.3-1.3-0.20.7-0.70.40.3-0.3
Stereotopy head waving bouts, day 71.01.22.0-0.50.9-0.9-1.01.21.21.30.71.21.21.11.41.21.21.21.41.3-0.4-1.40.8-0.81.20.6-0.5
Stereotopy head waving duration, day 70.81.03.20.50.2-0.3-0.60.70.71.00.30.90.70.81.20.90.90.91.21.8-0.9-1.21.4-1.41.50.8-0.8
Locomotion velocity, session 80.70.81.71.1-1.21.20.9-1.1-1.1-1.2-1.0-1.0-1.3-1.0-1.0-1.0-1.0-1.0-0.9-0.1-0.30.90.2-0.2-0.5-0.0-0.1
Locomotion distance, session 80.30.41.2-1.10.7-0.7-0.90.80.80.70.60.70.60.70.60.70.60.50.60.2-0.6-0.60.3-0.30.4-0.0-0.1
Degree of sensitization distance0.30.32.50.10.2-0.3-0.20.20.20.40.40.30.30.50.20.40.40.40.50.6-1.6-0.51.0-1.00.70.3-0.3
Degree of sensitization stereotypy0.30.31.80.5-0.0-0.0-0.30.40.40.6-0.20.50.50.40.90.50.50.60.71.3-0.3-0.80.7-0.70.9-0.10.1
Conditioned locomotion1.71.93.51.9-1.71.71.6-1.7-1.7-1.6-1.7-1.7-1.6-1.5-1.5-1.5-1.5-1.5-1.5-0.2-0.41.4-0.00.0-0.7-0.90.8
Cocaine response after cond. corrected0.20.20.8-0.70.7-0.7-0.30.30.30.40.20.20.50.30.00.30.30.00.0-0.90.6-0.0-0.60.6-0.3-0.30.4
Cocaine response after cond. not corrected0.20.30.7-0.80.8-0.8-0.60.60.60.60.50.50.70.50.40.50.50.40.3-0.40.6-0.3-0.40.4-0.00.00.1
Cocaine response before conditioning0.10.21.00.1-0.30.3-0.20.30.3-0.10.40.4-0.10.00.50.10.10.50.31.00.0-0.30.5-0.50.50.6-0.6
Saline control response0.91.22.61.4-1.61.51.1-0.8-0.8-1.3-1.0-0.6-1.5-0.9-0.6-0.9-0.8-0.5-0.51.0-1.40.51.6-1.60.41.0-1.0
Bone: connectivity density1.62.510.70.7-0.20.1-0.70.70.70.60.61.00.30.91.31.01.11.31.32.8-3.3-1.43.1-3.12.41.4-1.5
Bone: cortical apparent density0.50.71.10.7-0.80.81.0-0.9-0.9-0.8-0.9-0.9-0.8-0.9-1.0-0.9-0.9-0.9-0.9-0.81.00.9-0.60.6-0.8-0.20.3
Bone: cortical area0.40.71.30.9-1.21.10.8-0.8-0.8-1.0-0.9-0.8-1.0-1.0-0.6-0.9-0.9-0.7-0.90.2-0.00.9-0.30.3-0.5-1.11.0
Bone: cortical porosity0.50.51.9-0.10.3-0.3-0.50.50.50.40.20.60.20.60.60.60.60.50.70.7-0.5-0.71.1-1.10.91.4-1.4
Bone: cortical porosity0.30.31.40.3-0.10.0-0.10.10.10.0-0.10.1-0.20.30.20.20.30.10.30.6-0.7-0.31.2-1.20.71.1-1.1
Bone: cortical thickness4.26.910.63.0-3.23.23.1-3.1-3.1-3.1-3.1-3.0-3.1-3.0-2.8-3.0-3.0-2.8-2.8-0.80.72.7-0.90.9-2.0-1.61.4
Bone: cortical thickness2.22.64.31.5-1.71.81.9-2.0-2.0-2.0-1.7-2.0-1.9-1.8-2.1-1.8-1.8-1.9-1.7-1.20.71.7-0.50.5-1.40.2-0.2
Bone: cortical tissue density0.70.91.50.9-1.01.01.2-1.1-1.1-1.0-1.1-1.1-0.9-1.1-1.1-1.0-1.0-1.0-1.0-0.81.01.0-0.50.5-0.9-0.20.3
Condit. Reinf. active minus inactive responses0.20.20.80.0-0.10.1-0.30.40.4-0.00.20.4-0.10.20.50.30.30.40.50.9-0.6-0.50.8-0.80.60.6-0.7
Condit. Reinf. active-inactive response ratio0.20.20.5-0.10.1-0.1-0.30.40.40.10.50.50.10.30.60.30.30.60.50.7-0.2-0.50.4-0.40.50.5-0.5
Condit. Reinf. active responses0.10.10.4-0.0-0.10.1-0.20.30.3-0.10.20.3-0.20.10.40.20.20.30.30.7-0.6-0.30.6-0.60.50.2-0.3
Condit. Reinf. inactive responses0.00.00.2-0.30.2-0.2-0.30.20.20.20.10.20.10.20.20.20.20.10.10.1-0.4-0.10.2-0.20.2-0.10.1
Incentive salience index mean0.20.31.40.1-0.20.2-0.20.30.30.00.00.4-0.10.20.40.20.30.40.40.9-1.2-0.41.1-1.10.70.5-0.5
Condit. Reinf. lever presses0.10.11.10.3-0.50.50.2-0.1-0.1-0.3-0.6-0.1-0.4-0.30.1-0.2-0.2-0.1-0.20.2-1.00.20.4-0.40.2-0.40.5
Condit. Reinf. active minus inactive responses1.21.62.9-1.11.1-1.1-1.61.51.51.31.61.61.21.31.71.31.31.51.40.9-0.5-1.40.4-0.41.21.1-0.9
Condit. Reinf. active-inactive response ratio1.51.73.2-1.61.4-1.4-1.81.71.71.51.71.71.51.31.81.41.41.61.40.4-0.1-1.3-0.20.20.90.4-0.3
Condit. Reinf. active responses1.62.24.4-0.70.9-1.0-1.51.51.51.41.51.61.11.41.81.51.51.61.71.6-1.2-1.71.4-1.41.82.1-2.0
Condit. Reinf. inactive responses1.01.35.70.50.2-0.2-0.40.40.40.60.40.50.30.70.60.70.80.61.01.3-1.3-1.02.0-2.01.42.4-2.3
Condit. Reinf. lever presses0.50.72.61.0-0.70.60.00.20.20.00.00.3-0.30.10.70.20.20.40.71.3-1.4-0.71.2-1.21.11.6-1.5
Condit. Reinf. lever reinforcers received1.31.84.8-0.40.6-0.7-1.21.31.31.11.21.40.91.21.61.21.21.31.51.4-1.2-1.51.4-1.41.62.2-2.0
Conditioned reinforcement - actives0.10.21.9-0.3-0.20.20.0-0.1-0.10.10.0-0.1-0.1-0.3-0.0-0.2-0.2-0.1-0.30.10.70.3-0.70.7-0.4-1.41.2
Conditioned reinforcement - inactives1.21.73.8-1.91.7-1.7-1.71.71.71.81.51.51.61.31.41.31.21.21.10.01.1-1.0-1.11.10.2-0.10.0
Conditioned locomotion2.33.08.5-2.92.5-2.4-2.12.02.01.92.01.71.91.51.21.41.31.20.9-1.41.9-0.8-2.02.0-0.5-0.30.4
Patch foraging indifference point 0 sec0.30.61.6-0.90.7-0.7-0.90.90.90.61.30.90.70.80.90.80.81.10.80.8-0.1-0.80.4-0.40.60.7-0.9
Patch foraging indifference point AUC1.31.85.42.3-1.81.71.6-1.7-1.7-1.2-1.7-1.4-1.3-1.4-1.0-1.3-1.2-1.3-1.00.5-0.21.00.1-0.1-0.4-1.71.6
Delay disc. indifference point, 0s delay1.41.57.1-1.11.2-1.2-1.21.21.21.00.91.00.81.20.71.11.10.81.0-0.3-1.1-1.01.0-1.00.92.7-2.4
Delay disc. indifference point, 16s delay1.51.72.8-1.41.3-1.3-1.41.61.61.41.61.71.31.31.41.31.31.51.40.5-0.3-1.40.4-0.41.01.2-1.1
Delay disc. indifference point, 2s delay0.60.71.7-1.10.8-0.8-1.00.90.90.70.80.90.60.80.80.80.80.80.80.2-0.4-0.80.5-0.50.61.3-1.2
Delay disc. indifference point, 24s delay0.20.20.5-0.5-0.20.20.6-0.5-0.5-0.6-0.2-0.4-0.5-0.3-0.7-0.4-0.4-0.3-0.5-0.70.20.5-0.20.2-0.50.4-0.4
Delay disc. indifference point, 4s delay0.70.84.3-0.70.7-0.7-0.60.70.70.60.90.80.30.70.30.70.70.60.7-0.1-1.0-0.61.0-1.00.72.1-1.9
Delay disc. indifference point, 8s delay0.50.62.7-0.90.5-0.6-0.40.50.50.40.90.60.20.60.30.60.60.60.60.0-0.9-0.60.8-0.80.61.7-1.6
Indifference point function ln k1.62.911.9-3.42.6-2.5-1.92.02.01.52.11.51.61.50.81.31.21.00.8-1.91.3-0.7-1.51.5-0.61.1-1.0
Indifference point function log k1.62.911.9-3.42.6-2.5-1.92.02.01.52.11.51.61.50.81.31.21.00.8-1.91.3-0.7-1.51.5-0.61.1-1.0
Patch foraging total patch changes 0 sec0.00.10.5-0.60.2-0.2-0.20.30.3-0.00.60.20.10.10.10.10.10.30.10.30.3-0.1-0.00.0-0.10.5-0.7
Patch foraging total patch changes 12 sec1.21.65.42.3-1.81.71.6-1.4-1.4-1.0-1.5-1.2-1.1-1.0-0.7-0.9-0.9-0.8-0.51.5-1.40.41.6-1.60.5-0.2-0.0
Patch foraging total patch changes 18 sec0.20.32.00.9-0.40.40.3-0.3-0.30.1-0.0-0.1-0.00.00.10.00.10.20.31.4-0.7-0.30.9-0.90.6-0.40.2
Patch foraging total patch changes 24 sec0.81.32.61.6-1.61.61.3-1.5-1.5-1.3-1.2-1.4-1.3-1.3-1.1-1.3-1.2-1.1-1.10.4-0.11.10.2-0.2-0.5-0.70.5
Patch foraging total patch changes 6 sec0.30.52.41.3-0.80.80.5-0.4-0.4-0.3-0.4-0.3-0.4-0.2-0.0-0.2-0.1-0.10.21.5-1.0-0.21.3-1.30.70.4-0.6
Patch foraging time to switch 0 sec0.91.86.10.7-0.20.1-0.40.70.70.50.50.90.30.81.20.91.01.21.12.4-2.4-1.22.5-2.52.11.4-1.5
Patch foraging water rate 0 sec1.12.29.3-2.00.9-0.8-0.30.20.20.10.2-0.20.4-0.3-0.6-0.4-0.5-0.6-0.9-2.72.81.0-3.03.0-2.2-1.71.7
Patch foraging water rate 12 sec1.32.713.2-2.91.8-1.7-0.80.60.60.50.60.10.80.2-0.70.0-0.1-0.5-0.7-3.63.00.8-3.03.0-2.2-0.50.6
Patch foraging water rate 18 sec0.50.83.9-2.01.1-1.0-0.60.60.60.30.40.30.50.3-0.20.10.1-0.1-0.2-1.71.70.3-1.51.5-1.00.5-0.4
Patch foraging water rate 24 sec1.21.76.5-2.01.0-0.9-0.10.10.10.1-0.0-0.20.4-0.2-0.7-0.3-0.4-0.5-0.8-2.42.40.9-2.52.5-1.9-1.41.4
Patch foraging water rate 6 sec1.11.67.5-1.80.8-0.7-0.2-0.0-0.0-0.30.1-0.5-0.2-0.3-0.9-0.5-0.6-0.9-1.0-2.72.31.1-2.52.5-2.1-0.70.6
Seeking ratio, delayed vs. immediate footshock1.31.65.9-1.10.9-0.9-1.21.21.20.91.41.30.61.11.11.11.11.31.10.8-0.7-1.11.1-1.11.22.3-2.4
Distance traveled before self-admin0.30.41.0-0.10.1-0.1-0.40.50.50.30.50.60.40.40.70.50.50.80.61.0-0.9-0.60.9-0.90.90.5-0.5
Distance traveled after self-admin0.00.10.30.2-0.10.1-0.10.20.2-0.1-0.10.10.00.00.30.10.10.20.20.6-0.2-0.30.3-0.30.30.3-0.3
Extensor digitorum longus weight3.112.030.05.5-5.15.04.2-4.1-4.1-4.2-4.3-3.6-4.6-3.7-2.9-3.6-3.4-3.2-2.71.2-2.82.61.5-1.5-0.6-0.60.5
Bone: elastic displacement1.61.84.4-0.1-0.60.71.0-1.2-1.2-1.2-1.1-1.4-1.0-1.3-1.6-1.3-1.4-1.5-1.5-2.11.71.5-1.91.9-1.9-0.90.9
Bone: elastic work2.33.04.51.5-2.02.02.0-2.1-2.1-2.1-2.0-2.1-2.0-2.0-2.1-2.0-2.0-2.0-1.9-1.20.21.9-0.70.7-1.6-0.50.5
Bone: endosteal estimation2.14.56.7-2.62.3-2.4-2.52.62.62.22.52.52.12.42.42.42.32.42.21.1-1.7-2.11.2-1.21.81.1-1.1
Bone: endosteal perimeter3.77.812.4-3.02.9-2.9-3.43.43.42.93.53.42.83.03.43.13.03.33.02.1-1.8-2.91.2-1.22.40.8-0.9
Epididymis fat weight1.55.213.5-3.73.2-3.1-2.72.82.82.82.42.43.02.22.02.22.11.91.6-1.21.7-1.5-1.91.90.1-0.40.6
Delta time in closed arm before/after self-admin0.90.91.81.0-0.90.91.3-1.2-1.2-0.9-1.2-1.3-0.9-0.9-1.3-1.0-0.9-1.2-0.9-0.4-0.40.90.4-0.4-0.5-0.30.2
Delta time in open arm before/after self-admin0.20.22.50.5-0.20.20.0-0.0-0.00.0-0.40.10.2-0.10.4-0.0-0.00.10.00.50.3-0.1-0.30.30.1-1.51.6
Diff in mean of infusions in LGA sessions0.60.83.31.2-1.01.01.1-1.0-1.0-0.7-0.6-0.8-0.6-0.8-0.7-0.8-0.7-0.6-0.80.2-0.10.80.1-0.1-0.3-1.81.8
Delay discount exponential model param0.80.94.11.1-0.60.70.6-0.8-0.8-0.6-1.1-0.9-0.4-0.8-0.6-0.8-0.8-0.9-0.8-0.41.00.8-1.01.0-0.9-2.01.9
Extinction: sum of active levers before priming0.50.52.90.9-0.80.80.3-0.3-0.3-0.2-0.4-0.0-0.3-0.10.3-0.1-0.00.20.11.4-1.7-0.11.4-1.41.0-0.50.5
Active lever presses in extinction session 61.11.13.81.9-1.61.51.1-1.1-1.1-1.2-1.7-1.0-1.1-1.1-0.5-1.0-0.9-0.8-0.81.1-0.00.80.2-0.2-0.1-0.80.5
Bone: final force0.50.82.11.2-1.51.41.0-0.9-0.9-1.1-1.0-0.8-1.3-0.9-0.5-0.8-0.8-0.7-0.60.9-1.40.60.8-0.80.2-0.20.0
Bone: final moment0.50.71.91.1-1.41.30.8-0.8-0.8-1.1-0.9-0.7-1.3-0.8-0.5-0.8-0.7-0.6-0.60.9-1.30.50.8-0.80.2-0.1-0.1
Food consumed during 24 hour testing period0.20.31.30.2-0.40.40.5-0.2-0.2-0.3-0.5-0.2-0.3-0.5-0.2-0.5-0.5-0.4-0.4-0.71.10.4-1.01.0-0.6-0.10.2
Glucose3.45.47.8-2.62.8-2.8-2.72.72.72.62.82.62.42.72.42.62.62.52.50.9-0.7-2.51.1-1.11.91.7-1.6
Heart weight2.84.37.2-1.82.1-2.2-2.02.12.12.11.92.12.02.31.82.22.22.02.20.9-1.6-2.11.9-1.92.02.7-2.6
Delay discount hyperbolic model param0.91.04.21.1-0.70.70.8-0.9-0.9-0.6-1.2-1.0-0.4-0.9-0.7-0.8-0.8-1.0-0.9-0.41.00.9-1.01.0-0.9-2.01.9
Intermittent access intake day 1-15 change0.20.52.0-0.80.8-0.7-0.60.60.60.70.40.40.70.30.40.30.30.30.2-0.91.4-0.1-1.41.4-0.5-0.50.6
Intermittent access intake escalation0.20.52.3-0.60.6-0.5-0.40.40.40.50.30.20.50.10.30.10.10.10.0-0.81.40.0-1.51.5-0.6-0.90.9
Intermittent access intake escalation 20.60.62.4-0.70.6-0.6-0.40.40.40.50.30.20.60.10.20.10.10.2-0.0-0.71.50.1-1.61.6-0.7-1.61.5
Intermitt. access day 1 inactive lever presses0.00.10.3-0.10.2-0.2-0.20.30.30.30.30.20.30.10.30.20.20.30.2-0.10.3-0.2-0.50.5-0.0-0.30.5
Intermitt. access day 15 inactive lever presses0.71.52.5-1.11.5-1.4-1.41.51.51.61.51.41.41.31.61.41.31.41.40.50.2-1.3-0.40.40.80.4-0.3
Intermitt. access escalation Index1.31.84.8-2.22.1-2.0-1.61.61.61.61.71.41.61.61.01.51.41.11.1-0.60.1-1.0-0.20.20.50.1-0.0
Intermittent access day 1 total infusions4.47.110.4-2.72.9-2.9-3.23.13.13.22.93.22.83.02.93.03.02.92.81.6-1.4-2.81.4-1.42.51.8-1.7
Intermittent access day 15 total infusions2.84.27.7-2.82.6-2.6-2.62.62.62.72.32.42.62.22.22.22.12.11.90.20.6-1.8-0.60.61.00.2-0.1
Intermittent access terminal intake (last 3 days)3.64.78.5-2.62.7-2.6-2.82.72.72.92.42.72.72.42.52.42.42.42.20.80.2-2.2-0.10.11.40.2-0.1
Intermittent access total infusions4.35.08.2-2.52.6-2.6-2.82.72.72.92.52.72.62.52.62.52.52.42.41.2-0.6-2.30.6-0.61.81.0-0.9
Intermittent access day 1 locomotion3.44.46.2-2.02.3-2.3-2.42.42.42.52.32.42.22.32.32.32.32.32.31.3-1.1-2.21.0-1.01.91.7-1.6
Intermittent access day 15 total locomotion2.54.67.8-2.62.6-2.6-2.82.72.72.82.42.62.62.32.52.32.32.32.20.50.4-2.1-0.30.31.30.8-0.7
Intermittent access total locomotion7.28.613.7-3.43.5-3.5-3.73.73.73.73.43.63.33.23.33.23.23.23.11.1-0.2-3.00.2-0.22.01.7-1.6
Intermittent access standard deviation0.20.31.2-0.80.8-0.7-0.60.60.60.70.30.40.60.40.30.40.30.20.3-0.51.0-0.2-1.11.1-0.4-0.10.1
Left kidney weight0.31.23.7-1.91.7-1.6-1.31.31.31.41.11.11.41.10.71.00.90.60.6-1.3-0.0-0.5-0.80.8-0.10.10.1
Right kidney weight0.10.64.0-1.40.8-0.7-0.50.50.50.40.40.30.50.2-0.00.10.0-0.1-0.3-2.01.10.4-1.51.5-0.90.20.1
Cocaine induced anxiety0.00.00.30.2-0.00.0-0.10.10.10.2-0.10.10.00.00.30.10.10.10.20.50.1-0.2-0.20.20.1-0.30.2
Post-drug Anxiety0.20.20.60.7-0.70.70.5-0.4-0.4-0.3-0.5-0.4-0.5-0.5-0.2-0.4-0.4-0.4-0.20.6-0.10.20.0-0.0-0.0-0.80.6
Baseline Anxiety0.40.40.70.5-0.70.70.8-0.8-0.8-0.7-0.5-0.8-0.6-0.7-0.8-0.7-0.7-0.8-0.7-0.50.20.70.0-0.0-0.5-0.60.5
Tail length1.03.85.82.0-2.12.12.3-2.3-2.3-2.4-2.1-2.4-2.4-2.2-2.3-2.2-2.2-2.3-2.2-1.20.32.2-0.90.9-1.7-1.00.8
Length with tail1.67.112.23.5-3.33.33.1-3.3-3.3-3.3-3.1-3.1-3.4-2.9-2.8-2.9-2.9-2.9-2.7-0.4-0.12.7-0.30.3-1.6-1.41.0
Length without tail1.54.98.62.9-2.92.92.6-2.7-2.7-2.8-2.7-2.6-2.9-2.5-2.3-2.5-2.4-2.4-2.2-0.30.42.20.0-0.0-1.3-0.50.2
Times rat made contact with spout0.20.21.40.4-0.40.30.1-0.2-0.2-0.3-0.1-0.0-0.30.0-0.1-0.00.00.10.10.8-1.2-0.11.0-1.00.50.4-0.5
Lifetime Intake3.13.76.4-2.22.2-2.2-2.42.32.32.52.02.32.22.22.22.22.22.02.01.1-0.8-2.00.8-0.81.70.9-0.8
Liver weight, left0.30.52.4-0.70.3-0.30.2-0.3-0.3-0.2-0.3-0.5-0.1-0.3-0.8-0.4-0.4-0.6-0.7-1.50.90.7-1.01.0-1.0-0.91.0
Liver weight, right0.30.63.3-1.71.2-1.1-0.60.60.60.40.60.40.50.5-0.20.40.40.1-0.0-1.80.90.1-0.60.6-0.50.8-0.5
Locomotor activity0.50.84.3-1.40.4-0.40.0-0.0-0.0-0.40.0-0.3-0.3-0.3-0.9-0.4-0.5-0.6-0.7-2.11.50.8-1.41.4-1.40.1-0.0
Locomotor testing distance0.50.84.8-1.60.6-0.6-0.20.10.1-0.30.1-0.3-0.3-0.2-0.9-0.4-0.5-0.6-0.8-2.21.50.8-1.51.5-1.5-0.10.1
Locomotor testing rearing0.30.72.9-1.71.4-1.4-0.90.90.90.80.90.60.70.90.10.70.70.40.5-1.10.6-0.4-0.40.4-0.20.7-0.6
Locomotion in novel chamber2.22.88.4-2.92.4-2.3-2.12.12.11.92.11.81.91.71.41.61.51.51.3-0.91.3-1.2-1.11.10.10.4-0.4
Locomotion in novel chamber post-restriction1.01.64.3-2.11.8-1.8-1.61.61.61.61.31.31.71.31.11.21.21.11.0-0.61.0-1.0-0.70.70.1-0.00.2
Fecal boli incidents, locomotor time 10.20.33.20.6-0.00.10.10.10.10.2-0.5-0.00.4-0.10.20.00.00.00.10.50.4-0.2-0.60.6-0.1-1.61.8
Change in fecal boli incidents, locomotor task0.50.43.6-0.70.3-0.3-0.50.30.30.10.80.40.00.40.10.30.30.40.30.1-0.7-0.30.7-0.70.41.8-1.9
Time >=10cm from walls, locomotor time 13.94.26.0-1.91.9-1.9-2.32.32.32.22.42.41.92.12.52.22.22.42.21.7-0.9-2.20.7-0.71.92.1-2.1
Bouts of movement, locomotor time 10.40.41.51.2-1.11.10.8-0.7-0.7-0.8-0.7-0.6-0.8-0.8-0.3-0.7-0.6-0.4-0.50.60.10.5-0.10.1-0.1-0.50.5
Total resting periods, locomotor time 10.10.20.90.9-0.70.70.4-0.3-0.3-0.4-0.3-0.2-0.4-0.40.0-0.3-0.3-0.0-0.10.8-0.00.1-0.10.10.1-0.40.4
Rest time, locomotor task time 10.60.72.5-1.61.0-1.0-0.90.90.90.61.30.70.60.50.50.50.40.60.3-0.71.2-0.2-1.31.3-0.5-0.10.1
Distance moved, locomotor task time 10.60.92.70.20.3-0.3-0.50.50.50.70.30.70.40.70.80.80.80.61.01.2-1.3-1.01.5-1.51.31.6-1.7
Vertical activity count, locomotor time 10.10.20.5-0.50.6-0.6-0.20.30.30.60.30.30.60.40.10.40.40.20.3-0.50.2-0.3-0.10.10.00.7-0.6
Time >=10cm from walls, locomotor time 20.10.20.6-0.50.2-0.2-0.30.50.50.30.80.60.30.20.60.30.30.60.30.6-0.1-0.3-0.30.30.2-0.30.2
Bouts of movement, locomotor time 20.10.21.01.0-0.50.50.4-0.4-0.4-0.1-0.6-0.3-0.2-0.2-0.1-0.1-0.1-0.1-0.00.6-0.5-0.00.4-0.40.4-0.30.4
Total resting periods, locomotor time 20.10.10.40.6-0.20.10.1-0.1-0.10.2-0.30.00.10.10.20.20.20.20.30.6-0.6-0.30.5-0.50.5-0.30.4
Rest time, locomotor task time 20.60.82.3-1.51.4-1.4-1.01.01.01.11.20.81.10.90.60.90.80.60.7-0.60.6-0.7-0.70.7-0.00.10.1
Distance moved, locomotor task time 20.40.51.41.1-1.21.20.9-0.8-0.8-0.9-0.6-0.7-1.0-0.8-0.5-0.8-0.8-0.6-0.70.2-0.10.70.2-0.2-0.20.4-0.5
Vertical activity count, locomotor time 21.41.92.90.7-1.21.21.6-1.5-1.5-1.4-1.3-1.4-1.3-1.5-1.6-1.5-1.5-1.5-1.7-1.61.31.7-1.21.2-1.6-0.40.4
Light reinforcement 10.00.10.5-0.70.3-0.3-0.30.30.3-0.00.30.20.10.1-0.10.10.00.0-0.2-0.50.30.2-0.10.1-0.20.5-0.4
Light reinforcement 20.40.61.2-1.00.9-0.9-1.10.90.90.80.91.00.90.60.80.60.60.70.5-0.30.5-0.5-0.90.9-0.1-0.50.6
Bone: marrow area2.24.76.9-2.62.4-2.4-2.52.62.62.32.62.62.22.42.42.42.42.42.21.1-1.8-2.21.2-1.21.91.1-1.0
Bone: maximum diameter0.10.21.1-0.4-0.00.0-0.40.40.40.10.40.40.10.10.60.20.10.40.00.5-0.0-0.0-0.40.40.1-1.10.9
Bone: maximum force0.61.05.21.1-1.00.90.00.00.0-0.40.00.3-0.6-0.00.70.10.10.50.52.3-2.3-0.61.8-1.81.40.7-0.9
Bone: maximum moment0.61.04.71.0-1.00.9-0.00.00.0-0.40.00.3-0.6-0.00.70.10.10.50.52.2-2.1-0.61.7-1.71.30.8-1.0
Mean time between licks in bursts0.20.40.90.2-0.70.70.7-0.6-0.6-0.9-0.6-0.6-0.9-0.6-0.8-0.7-0.7-0.7-0.7-0.20.00.70.2-0.2-0.40.4-0.5
Mean num. licks in bursts0.10.10.50.00.5-0.5-0.20.10.10.40.20.10.30.40.00.30.30.10.4-0.0-0.7-0.30.3-0.30.2-0.0-0.0
Cd content in liver0.91.02.2-1.51.3-1.3-1.31.21.21.11.01.11.41.01.01.01.01.00.90.01.0-0.9-0.30.30.40.2-0.2
Co content in liver1.61.85.4-0.4-0.30.30.9-1.1-1.1-0.9-0.7-1.3-0.8-1.1-1.7-1.2-1.3-1.5-1.4-2.31.71.5-1.91.9-2.0-1.21.3
Cu content in liver0.30.41.9-0.10.3-0.3-0.40.40.40.50.30.40.40.50.40.50.50.40.70.3-0.5-0.60.7-0.70.61.4-1.3
Fe content in liver0.40.51.00.7-0.70.80.9-0.8-0.8-0.7-1.0-0.8-0.6-0.8-0.9-0.8-0.8-0.8-0.7-0.30.30.7-0.30.3-0.6-0.50.5
K content in liver0.30.20.90.3-0.30.20.0-0.0-0.0-0.1-0.00.1-0.20.10.10.10.10.20.30.7-1.0-0.41.0-1.00.60.9-0.9
Mg content in liver0.70.72.1-0.80.8-0.9-0.90.90.90.70.90.80.70.90.70.80.80.81.00.3-0.1-1.00.4-0.40.71.4-1.3
Mn content in liver0.80.94.22.0-1.61.51.0-1.0-1.0-0.9-1.3-0.7-1.0-0.9-0.3-0.8-0.7-0.5-0.41.4-0.30.30.5-0.50.3-0.60.5
Na content in liver0.80.91.20.5-1.01.00.8-0.8-0.8-1.0-0.7-0.8-0.9-1.1-0.8-1.1-1.1-0.8-1.0-1.00.91.0-1.11.1-1.1-0.60.7
Rb content in liver1.31.52.6-1.31.6-1.6-1.41.31.31.41.51.21.31.41.01.31.31.21.40.2-0.4-1.40.5-0.50.81.2-1.1
Se content in liver0.40.40.8-0.40.6-0.6-0.70.80.80.90.50.80.90.70.90.70.70.70.90.7-0.0-0.80.1-0.10.6-0.0-0.0
Sr content in liver2.11.83.31.8-1.71.71.6-1.6-1.6-1.6-1.6-1.5-1.5-1.6-1.3-1.5-1.5-1.3-1.4-0.20.81.4-0.50.5-0.9-0.80.8
Zn content in liver0.20.20.40.6-0.50.40.5-0.5-0.5-0.3-0.5-0.5-0.4-0.3-0.4-0.3-0.3-0.4-0.1-0.2-0.50.20.5-0.50.00.6-0.6
Bone: minimum diameter3.36.08.2-2.32.4-2.4-2.72.82.82.52.92.82.32.72.82.72.72.82.71.9-2.1-2.71.7-1.72.41.5-1.6
Time in familiar zone, hab. session 10.80.81.5-0.90.9-0.9-1.21.11.10.81.11.10.80.91.10.90.91.01.00.5-0.2-1.00.4-0.40.81.0-0.9
Time in novel zone, hab. session 10.40.40.80.2-0.20.30.8-0.6-0.6-0.5-0.6-0.7-0.5-0.6-0.9-0.6-0.6-0.8-0.8-0.80.70.8-0.70.7-0.9-0.60.4
Total zone transitions, hab. session 10.20.30.90.6-0.70.60.3-0.2-0.2-0.6-0.3-0.1-0.7-0.3-0.0-0.2-0.2-0.10.00.8-0.9-0.00.8-0.80.40.4-0.6
Total locomotion distance, hab. session 10.30.41.1-1.00.8-0.8-0.80.80.80.51.00.80.60.70.70.70.70.80.60.3-0.4-0.60.1-0.10.4-0.20.1
Locomotion velocity, hab. session 10.10.10.4-0.60.3-0.3-0.40.40.40.10.60.40.20.40.40.30.40.40.30.4-0.7-0.30.2-0.20.3-0.30.1
Time in familiar zone, hab. session 20.50.51.00.7-0.60.60.8-0.9-0.9-0.8-0.8-0.9-0.7-0.7-1.0-0.8-0.8-0.9-0.8-0.60.60.7-0.50.5-0.7-0.40.5
Time in novel zone, hab. session 20.70.71.1-0.40.6-0.6-0.80.80.80.80.90.90.60.80.90.80.80.90.90.8-1.0-0.90.9-0.91.01.0-1.1
Total zone transitions, hab. session 23.03.810.8-0.30.6-0.7-1.41.31.31.01.41.50.71.61.71.61.71.82.02.8-2.8-2.13.3-3.32.62.5-2.7
Total locomotion distance, hab. session 21.82.43.6-1.21.2-1.2-1.51.41.41.11.71.51.11.61.51.51.61.71.71.7-1.6-1.71.9-1.91.81.4-1.5
Locomotion velocity, hab. session 22.02.73.7-1.41.4-1.4-1.81.61.61.31.91.71.31.71.71.71.71.91.81.7-1.6-1.81.8-1.81.81.3-1.4
Novel to familiar place preference ratio0.20.31.00.7-0.20.2-0.30.20.20.40.20.40.40.20.70.40.40.60.41.0-0.6-0.50.7-0.70.8-0.30.4
Novelty place preference0.30.40.80.40.2-0.2-0.60.50.50.60.60.60.70.50.90.60.60.90.60.9-0.5-0.60.6-0.60.9-0.20.3
Time in novel zone, NPP test0.30.30.70.30.2-0.2-0.60.50.50.60.60.60.70.50.80.60.60.80.60.8-0.5-0.60.6-0.60.8-0.00.1
Total zone transitions, NPP test0.60.84.00.5-0.70.70.0-0.1-0.1-0.5-0.10.0-0.7-0.00.2-0.00.00.20.31.5-2.0-0.41.9-1.91.01.2-1.4
Total locomotion distance, NPP test0.30.42.3-0.70.3-0.3-0.60.50.50.10.60.50.00.50.40.40.40.40.50.5-1.5-0.50.9-0.90.60.6-0.6
Locomotion velocity, NPP test0.20.32.2-0.60.2-0.2-0.50.40.40.00.60.4-0.10.40.40.30.40.40.40.5-1.5-0.40.8-0.80.60.4-0.4
Intraocular pressure0.70.95.2-0.10.4-0.30.0-0.1-0.10.40.0-0.20.5-0.2-0.1-0.1-0.1-0.2-0.4-0.82.00.4-1.71.7-0.9-2.22.3
Delta distance traveled before/after self-admin0.30.30.50.2-0.30.30.6-0.5-0.5-0.5-0.5-0.6-0.3-0.5-0.7-0.5-0.5-0.7-0.6-0.60.60.6-0.60.6-0.7-0.70.6
Delta ambulatory time before/after self-admin0.20.30.60.4-0.40.40.7-0.6-0.6-0.5-0.5-0.6-0.5-0.6-0.7-0.6-0.6-0.7-0.6-0.60.50.6-0.50.5-0.7-0.0-0.0
Parametrial fat weight1.63.78.4-2.62.9-2.8-2.22.32.32.72.22.12.72.21.72.12.11.71.6-0.70.5-1.6-0.60.60.70.20.0
Pavlov. Cond. lever latency0.10.10.5-0.50.3-0.3-0.30.30.30.10.40.20.20.10.10.10.10.2-0.0-0.10.70.0-0.60.6-0.2-0.10.0
Pavlov. Cond. magazine entry latency0.81.01.7-0.50.5-0.5-1.01.01.00.70.61.00.60.91.20.91.01.11.21.1-1.3-1.21.1-1.11.31.2-1.1
Pavlov. Cond. change in total contacts0.40.41.2-0.30.3-0.3-0.70.80.80.60.50.90.60.61.10.70.70.80.80.8-0.4-0.80.4-0.40.70.1-0.1
Pavlov. Cond. index score0.00.00.10.0-0.10.1-0.10.10.10.0-0.10.1-0.10.00.30.10.10.10.20.3-0.3-0.20.1-0.10.2-0.00.0
Pavlov. Cond. latency score0.00.10.2-0.00.0-0.1-0.20.20.20.20.00.20.10.20.40.20.20.30.30.3-0.5-0.30.3-0.30.40.1-0.1
Pavlov. Cond. lever contacts0.10.10.50.1-0.00.0-0.00.00.00.1-0.20.00.00.10.10.10.10.00.30.0-0.7-0.20.6-0.60.30.5-0.3
Pavlov. Cond. magazine entry number0.00.00.1-0.00.3-0.30.0-0.0-0.00.20.3-0.00.30.2-0.20.10.1-0.0-0.0-0.4-0.10.00.1-0.1-0.00.2-0.1
Pavlov. Cond. intertrial magazine entries0.20.20.7-0.20.0-0.00.2-0.1-0.10.1-0.1-0.20.1-0.2-0.2-0.2-0.2-0.2-0.3-0.60.80.4-0.70.7-0.5-0.80.8
Pavlov. Cond. lever-magazine prob. diff.0.00.10.30.1-0.20.1-0.20.20.20.1-0.20.2-0.10.10.40.10.10.20.30.4-0.5-0.30.4-0.40.40.1-0.1
Pavlov. Cond. response bias0.00.00.20.0-0.30.30.0-0.0-0.0-0.2-0.4-0.1-0.3-0.20.1-0.2-0.2-0.1-0.10.10.10.1-0.00.0-0.00.0-0.0
Pavlov. Cond. lever latency0.10.20.6-0.70.7-0.7-0.60.40.40.40.60.40.60.50.10.50.50.40.20.20.2-0.30.1-0.10.1-0.40.3
Pavlov. Cond. magazine entry latency0.91.14.31.7-1.31.20.3-0.4-0.4-0.6-0.5-0.1-0.9-0.30.4-0.2-0.10.10.32.1-1.8-0.31.8-1.81.30.8-0.9
Pavlov. Cond. change in total contacts0.40.61.60.8-0.40.4-0.40.40.40.30.20.60.00.31.00.40.40.60.81.2-1.0-0.81.1-1.11.21.3-1.0
Pavlov. Cond. index score0.40.51.61.3-1.00.90.2-0.2-0.2-0.4-0.4-0.0-0.7-0.20.4-0.1-0.10.00.21.2-1.3-0.31.1-1.10.90.9-0.8
Pavlov. Cond. latency score0.30.41.41.2-1.00.90.2-0.2-0.2-0.4-0.4-0.1-0.7-0.30.3-0.2-0.20.00.11.2-1.2-0.20.9-0.90.70.5-0.5
Pavlov. Cond. lever contacts0.10.10.50.7-0.60.60.4-0.2-0.2-0.2-0.5-0.2-0.5-0.40.0-0.3-0.3-0.2-0.10.0-0.20.10.1-0.10.10.6-0.4
Pavlov. Cond. magazine entry number1.21.55.2-2.21.8-1.7-0.70.70.71.00.90.31.30.6-0.20.50.40.1-0.0-2.31.80.1-1.91.9-1.2-0.80.9
Pavlov. Cond. intertrial magazine entries0.30.41.1-1.11.0-1.0-0.70.70.70.70.80.60.80.60.40.60.50.50.3-0.40.8-0.3-0.70.7-0.2-0.20.2
Pavlov. Cond. lever-magazine prob. diff.0.50.62.21.5-1.11.10.3-0.3-0.3-0.4-0.4-0.1-0.8-0.30.4-0.2-0.20.00.21.4-1.4-0.21.2-1.20.90.9-0.8
Pavlov. Cond. response bias0.30.51.51.2-0.90.80.3-0.2-0.2-0.3-0.4-0.0-0.6-0.20.3-0.1-0.1-0.00.21.0-1.0-0.31.0-1.00.81.2-1.0
Time in closed arm before self-admin1.11.42.4-1.31.2-1.2-1.61.51.51.01.51.51.11.21.51.31.21.51.30.7-0.0-1.30.2-0.20.91.1-1.2
Time in closed arm after self-admin0.10.10.4-0.60.3-0.3-0.30.30.30.20.30.20.10.30.20.30.30.30.20.2-0.0-0.2-0.00.00.1-0.1-0.0
Time in open arm before self-admin0.70.82.50.1-0.40.41.0-0.9-0.9-0.9-0.7-1.0-0.9-0.7-1.4-0.8-0.9-1.1-1.0-1.60.11.0-0.10.1-0.90.8-0.8
Time in open arm after self-admin0.30.30.90.5-0.50.50.7-0.7-0.7-0.6-1.0-0.6-0.4-0.5-0.7-0.5-0.5-0.7-0.6-0.50.20.5-0.10.1-0.4-0.20.4
Bone: periosteal estimation0.30.61.1-0.90.6-0.6-0.91.01.00.70.91.00.60.71.00.80.80.90.70.8-1.0-0.60.3-0.30.7-0.30.2
Bone: periosteal perimeter0.61.13.0-0.70.6-0.6-1.11.21.20.91.21.20.70.91.41.01.01.31.11.7-1.2-1.10.8-0.81.2-0.1-0.1
Bone: post-yield work7.110.417.2-1.32.0-2.1-3.23.23.22.83.33.52.63.23.93.33.43.93.64.1-3.5-3.73.5-3.54.12.4-2.4
Progressive ratio test 1 active lever presses0.30.40.8-0.80.5-0.5-0.70.70.70.90.70.70.70.60.70.60.60.60.50.6-0.3-0.40.4-0.40.6-0.70.7
Progressive ratio test 1 breakpoint0.30.40.7-0.70.5-0.5-0.70.60.60.80.60.70.70.50.70.60.60.60.40.6-0.3-0.40.4-0.40.6-0.80.8
Progressive ratio test 1 inactive lever presses0.10.20.4-0.30.3-0.3-0.40.40.40.50.50.50.50.40.50.40.40.50.50.5-0.2-0.50.1-0.10.40.6-0.6
Progressive ratio test 2 active lever presses1.92.33.9-1.91.8-1.7-1.91.91.92.01.71.91.81.61.71.61.61.61.50.50.2-1.5-0.10.11.00.8-0.7
Progressive ratio test 2 breakpoint1.82.03.5-1.81.7-1.7-1.81.81.81.91.61.81.71.51.61.51.51.51.40.50.3-1.4-0.20.20.90.7-0.6
Progressive ratio test 2 inactive lever presses4.06.412.2-3.53.3-3.2-3.13.23.23.33.03.03.02.72.62.72.62.62.4-0.10.7-2.3-0.70.71.11.5-1.4
Incentive Sensitization - Responses0.71.02.7-0.40.6-0.7-1.11.01.00.80.71.10.80.91.21.01.01.11.11.0-0.9-1.20.7-0.71.11.6-1.5
Incentive Sensitization - Breakpoint0.81.12.6-0.50.8-0.8-1.21.11.10.90.81.20.91.01.31.11.11.11.20.9-0.8-1.20.6-0.61.11.6-1.5
Sum of active levers in priming session hrs 5-63.43.16.31.7-1.81.91.6-1.7-1.7-1.5-1.8-1.6-1.5-1.9-1.2-1.8-1.8-1.6-1.8-0.41.91.8-2.02.0-1.7-2.52.3
Progressive ratio1.82.97.60.20.6-0.6-1.21.11.11.20.91.30.91.41.61.51.51.51.72.4-2.3-1.72.8-2.82.42.3-2.4
Food seeking constrained by brief footshock0.30.31.80.8-0.50.50.5-0.6-0.6-0.4-0.5-0.6-0.5-0.4-0.5-0.4-0.4-0.5-0.2-0.2-0.30.20.3-0.3-0.11.3-1.4
Seeking ratio, punishment vs. effort1.01.55.6-0.4-0.20.30.8-0.8-0.8-0.8-0.4-1.0-0.7-1.0-1.4-1.0-1.1-1.2-1.3-2.41.61.3-2.12.1-1.9-0.80.9
Retroperitoneal fat weight3.414.540.8-6.45.8-5.6-4.64.74.74.54.24.04.84.03.03.83.63.12.8-2.61.8-2.6-2.52.50.30.8-0.3
Reaction time number correct0.50.91.50.6-0.91.00.9-1.0-1.0-1.2-1.1-1.0-1.0-1.1-1.0-1.1-1.1-1.1-1.1-0.71.11.1-0.80.8-1.0-0.50.5
Reaction time mean minus median0.40.93.92.0-1.61.51.1-0.9-0.9-1.0-1.0-0.7-1.1-0.9-0.3-0.7-0.7-0.4-0.51.3-0.40.40.9-0.90.4-0.20.1
Reaction time mean minus median AUC0.51.33.51.9-1.61.61.4-1.4-1.4-1.4-1.4-1.2-1.4-1.3-0.9-1.2-1.2-0.9-1.10.40.51.00.1-0.1-0.4-0.70.6
Reaction time num false alarms0.60.92.0-0.1-0.50.50.7-0.9-0.9-0.9-0.6-1.0-0.8-0.9-1.3-1.0-1.0-1.1-1.1-1.40.21.2-0.90.9-1.3-0.91.0
Reaction time num false alarms AUC0.71.22.10.5-1.01.01.0-1.3-1.3-1.3-0.8-1.3-1.3-1.2-1.4-1.2-1.2-1.3-1.3-1.0-0.01.3-0.60.6-1.1-0.90.8
Reaction time trials correct on left0.50.91.50.6-0.91.00.9-1.0-1.0-1.2-1.1-1.0-1.0-1.1-1.0-1.1-1.1-1.1-1.1-0.71.11.1-0.80.8-1.0-0.50.5
Reaction time trials on left0.61.21.80.8-1.11.11.0-1.1-1.1-1.4-1.2-1.1-1.2-1.2-1.1-1.2-1.2-1.2-1.2-0.71.21.2-0.90.9-1.1-0.60.6
Reaction time mean0.00.10.40.0-0.00.00.00.20.20.10.00.20.00.10.30.20.20.20.20.30.6-0.20.2-0.20.30.6-0.6
Reaction time mean AUC0.10.10.4-0.10.2-0.2-0.20.40.40.30.20.40.30.30.50.30.30.50.30.40.5-0.30.2-0.20.40.6-0.6
Median of all reaction times0.20.30.7-0.60.6-0.6-0.50.70.70.60.50.60.50.50.60.60.60.60.60.20.5-0.50.1-0.10.40.9-0.9
Reaction time omissions0.91.33.71.9-1.61.61.5-1.3-1.3-1.1-1.3-1.1-1.3-1.2-0.9-1.1-1.0-0.9-0.90.7-0.20.90.5-0.5-0.1-1.31.1
Reaction time false alarm rate0.20.30.7-0.0-0.30.30.4-0.6-0.6-0.5-0.2-0.6-0.6-0.5-0.8-0.5-0.6-0.6-0.7-0.7-0.40.7-0.40.4-0.6-0.60.6
Reaction time premature initiation rate1.62.23.81.8-1.91.91.9-1.7-1.7-1.9-1.9-1.6-1.9-1.6-1.8-1.6-1.5-1.5-1.30.4-0.41.30.9-0.9-0.60.2-0.5
Reaction time premature initiations2.44.37.52.4-2.72.72.5-2.4-2.4-2.7-2.6-2.3-2.7-2.3-2.4-2.4-2.3-2.2-2.1-0.00.32.00.4-0.4-1.3-0.30.0
Std. dev. reaction times0.10.31.11.0-0.80.80.7-0.4-0.4-0.5-0.6-0.3-0.6-0.5-0.1-0.4-0.3-0.2-0.30.60.20.20.5-0.50.20.3-0.3
Reaction time trials completed0.61.21.80.8-1.11.11.0-1.1-1.1-1.4-1.2-1.1-1.2-1.2-1.1-1.2-1.2-1.2-1.2-0.71.21.2-0.90.9-1.1-0.60.6
Reaction time trials AUC0.50.91.50.6-0.90.90.9-1.0-1.0-1.2-1.1-1.0-1.0-1.0-1.0-1.0-1.0-1.1-1.1-0.71.11.0-0.80.8-1.0-0.40.4
Run reversals in cocaine runway, females0.70.74.80.3-0.10.0-0.0-0.0-0.00.0-0.50.0-0.20.30.10.30.30.00.50.8-1.3-0.51.2-1.20.82.1-2.2
Run reversals in cocaine runway, males2.32.44.10.8-0.91.01.5-1.4-1.4-1.3-1.3-1.6-1.2-1.5-1.7-1.6-1.6-1.7-1.6-1.91.91.6-2.02.0-2.0-1.21.3
Latency to leave start box in cocaine runway1.11.32.0-0.60.9-0.9-1.31.21.21.01.41.31.11.21.31.21.21.41.41.2-0.9-1.41.0-1.01.30.5-0.5
Latency to leave start box in cocaine runway, F0.60.71.1-0.40.7-0.7-1.00.90.90.71.00.90.80.90.90.90.91.01.00.8-0.7-1.00.9-0.91.00.6-0.6
Latency to leave start box in cocaine runway, M0.20.10.60.10.1-0.1-0.30.30.30.30.50.40.20.30.50.30.40.50.50.8-0.4-0.50.3-0.30.5-0.10.1
Std. dev. time between licks in bursts0.81.12.50.1-0.70.81.0-1.1-1.1-1.2-0.9-1.3-1.2-1.1-1.6-1.1-1.2-1.4-1.4-1.30.71.4-0.70.7-1.2-0.30.2
Total sessions with >9 infusions0.91.12.5-0.60.6-0.7-1.00.90.91.10.71.10.91.01.11.11.11.01.01.2-1.6-1.01.4-1.41.40.9-0.8
Short access day 1 total inactive lever presses1.01.33.2-1.81.6-1.6-1.41.41.41.51.01.21.51.20.91.11.10.91.0-0.90.2-0.9-0.30.30.31.1-0.7
Short access day 10 total inactive lever presses0.00.00.1-0.00.3-0.3-0.10.10.10.20.10.00.20.10.00.10.10.00.2-0.10.2-0.2-0.30.3-0.10.2-0.1
Short access day 1 total infusions1.82.43.9-1.81.8-1.8-1.91.91.92.01.31.91.81.81.61.81.71.51.60.4-0.9-1.60.6-0.61.30.9-0.7
Short access day 10 total infusions4.05.17.2-1.41.8-1.9-2.32.32.32.62.02.42.12.42.52.42.42.42.52.3-2.3-2.42.2-2.22.71.7-1.7
Short access total infusions1.72.23.6-1.21.3-1.3-1.51.51.51.91.11.61.41.61.51.61.61.41.61.3-1.6-1.51.5-1.51.71.0-1.0
Short access day 1 locomotion1.51.93.0-1.41.6-1.6-1.71.51.51.71.51.61.51.61.61.61.61.51.50.9-0.6-1.50.6-0.61.20.6-0.5
Short access day 10 total locomotion1.42.54.0-1.11.6-1.6-1.81.81.81.71.51.81.61.71.81.71.71.71.81.0-0.9-1.80.6-0.61.42.0-1.9
Short access total locomotion2.12.53.7-1.51.7-1.7-1.91.81.81.91.71.91.71.81.81.81.81.81.71.0-0.8-1.70.6-0.61.41.3-1.2
One hour access (0.3 mA shock)3.03.47.0-2.62.6-2.5-2.32.32.32.32.12.12.22.01.82.01.91.81.7-0.20.9-1.6-0.70.70.70.9-0.8
Compulsive drug intake3.23.86.41.8-2.22.22.5-2.4-2.4-2.3-2.1-2.5-2.3-2.1-2.5-2.2-2.2-2.3-2.1-1.10.12.0-0.00.0-1.5-0.70.6
One hour access (shock baseline)3.85.89.8-3.03.1-3.1-3.13.03.03.02.72.82.92.62.72.62.52.52.30.20.9-2.2-0.90.91.10.9-0.7
Social response proportion0.20.21.80.5-0.20.2-0.20.10.1-0.30.50.4-0.00.20.50.20.30.60.31.4-0.1-0.40.8-0.80.70.3-0.5
Social responses0.20.20.50.7-0.60.60.5-0.6-0.6-0.7-0.3-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.40.20.50.40.2-0.2-0.20.1-0.3
Social time0.40.51.01.0-0.80.80.9-0.9-0.9-1.0-0.8-0.8-0.9-0.7-0.8-0.7-0.7-0.7-0.7-0.20.30.70.0-0.0-0.40.0-0.2
Soleus weight0.82.59.9-3.22.4-2.3-1.51.51.51.41.31.01.71.20.41.00.90.60.5-2.61.4-0.4-2.12.1-1.0-0.10.4
Bone: stiffness0.81.25.90.9-0.40.3-0.40.40.40.30.40.70.00.51.10.60.70.91.02.4-2.1-1.11.9-1.91.70.7-0.9
Tibialis anterior weight6.120.840.76.4-6.46.35.5-5.5-5.5-5.6-5.6-5.1-5.8-5.2-4.3-5.1-4.9-4.6-4.40.1-0.84.30.0-0.0-2.2-2.11.9
Time to tail flick, vehicle, before self-admin0.20.20.90.10.1-0.1-0.30.30.30.30.20.30.10.40.40.40.40.40.50.8-0.9-0.60.8-0.80.70.4-0.4
Time to tail flick, vehicle, after self-admin0.81.03.7-0.00.2-0.2-0.30.50.50.20.20.50.30.70.60.70.80.70.71.1-1.8-0.81.9-1.91.41.6-1.5
Time to tail flick, test, before self-admin2.72.85.0-2.01.8-1.8-1.81.81.81.71.81.81.61.81.41.71.71.51.70.6-1.0-1.71.1-1.11.42.2-2.2
Time to tail flick, test, after self-admin0.10.10.9-0.3-0.00.0-0.10.20.20.2-0.00.10.1-0.00.30.10.10.20.10.50.3-0.0-0.30.30.0-1.00.9
Delta time to tail flick, vehicle, before/after SA0.50.52.70.2-0.10.0-0.10.20.2-0.10.10.30.10.30.40.40.40.40.40.8-0.8-0.41.2-1.20.81.6-1.6
Delta time to tail flick, test, before/after SA4.84.912.81.9-2.12.22.3-2.2-2.2-2.1-2.3-2.2-1.9-2.3-1.9-2.2-2.2-2.0-2.4-0.91.82.3-1.91.9-2.0-3.63.5
Tibia length0.61.73.11.1-1.71.71.3-1.2-1.2-1.5-1.2-1.1-1.4-1.5-0.9-1.4-1.4-1.1-1.5-0.40.91.5-1.01.0-0.9-1.71.7
Ambulatory time before self-admin0.40.61.8-0.20.3-0.3-0.70.80.80.60.60.90.60.71.20.80.81.10.91.4-0.8-0.90.9-0.91.10.3-0.2
Ambulatory time after self-admin1.21.42.4-0.91.1-1.1-1.41.51.51.21.31.41.21.21.51.31.31.41.41.1-0.3-1.40.4-0.41.10.7-0.7
Bone: tissue strength0.20.20.4-0.50.3-0.3-0.60.60.60.40.40.60.40.50.60.50.50.50.60.5-0.4-0.60.4-0.40.50.5-0.5
Total heroin consumption1.41.73.92.0-2.01.91.6-1.5-1.5-1.5-1.3-1.3-1.3-1.3-0.9-1.2-1.2-0.9-1.11.0-0.91.01.0-1.00.0-1.21.0
Bone: trabecular number1.62.66.30.00.5-0.6-1.21.31.31.20.91.51.01.41.81.51.51.61.72.5-2.4-1.72.5-2.52.41.2-1.2
Bone: trabecular spacing0.30.31.4-0.30.0-0.00.4-0.4-0.4-0.4-0.4-0.6-0.3-0.4-0.8-0.4-0.5-0.7-0.6-1.21.00.6-0.80.8-0.90.4-0.4
Bone: trabecular thickness1.72.23.2-1.31.4-1.4-1.61.71.71.61.51.71.51.61.81.71.71.71.61.0-0.8-1.61.2-1.21.61.0-0.8
Bone: trabecular tissue density1.11.65.9-2.11.4-1.3-0.80.90.90.80.80.60.90.50.30.40.30.2-0.0-1.91.70.1-2.42.4-1.1-1.61.7
Water consumed over 24 hours0.20.30.70.8-0.80.80.6-0.5-0.5-0.7-0.4-0.4-0.7-0.5-0.4-0.5-0.4-0.3-0.30.4-0.40.30.6-0.60.20.8-0.8
Number of responses in last shaping day0.10.20.40.2-0.20.20.6-0.5-0.5-0.1-0.5-0.6-0.3-0.4-0.6-0.4-0.4-0.6-0.3-0.30.10.3-0.10.1-0.4-0.50.5