Hub : Genes

Ccs

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Ccs 0.05 0.04 3.3e-04 0.03 0.02 0.03 0.02 2.0e-03 5.7e-03 1.6e-03 2.9e-03
2 LHb alternative TSS XM_039092800.2 0.15 0.1 3.5e-03 0.05 0.08 0.04 0.06 2.9e-02 6.2e-03 4.1e-02 1.6e-02
3 LHb alternative TSS NM_053425.1 0.15 0.1 4.0e-03 0.06 0.08 0.04 0.06 1.5e-02 6.7e-03 4.8e-02 1.7e-02
4 Liver mRNA stability Ccs 0.04 0.03 1.4e-03 0.02 0.01 0.01 0.02 1.1e-03 1.0e-02 4.5e-02 4.4e-03
5 IL gene expression Ccs 0.61 0.17 2.1e-10 0.28 0.12 0.24 0.03 1.7e-07 9.7e-04 1.8e-06 5.3e-02
6 LHb gene expression Ccs 0.35 0.15 2.4e-06 0.26 0.22 0.21 0.23 7.8e-07 5.3e-06 1.2e-05 3.9e-06
7 Liver gene expression Ccs 0.06 0.04 9.4e-06 0.03 0.03 0.03 0.02 2.2e-04 2.6e-04 8.3e-04 1.0e-03
8 OFC gene expression Ccs 0.62 0.14 2.9e-09 0.27 0.07 0.25 0 4.2e-07 8.2e-03 1.5e-06 2.9e-01
9 NAcc gene expression Ccs 0.4 0.12 0.0e+00 0.39 0.4 0.39 0.4 4.5e-63 4.2e-64 8.3e-63 3.1e-64
10 Liver intron excision ratio chr1_211543488_211543586 0.03 0.02 3.3e-03 0.01 -0 -0 0 2.8e-02 4.2e-01 6.1e-01 2.2e-01
11 IC gene expression Ccs 0.4 0.15 1.1e-16 0.34 0.36 0.33 0.36 3.8e-15 4.0e-16 1.6e-14 7.8e-16
12 BLA gene expression Ccs 0.61 0.1 0.0e+00 0.41 0.44 0.44 0.43 2.7e-23 1.4e-25 3.0e-25 7.6e-25
13 pVTA gene expression Ccs 0.44 0.14 0.0e+00 0.43 0.46 0.45 0.46 1.3e-37 1.7e-40 6.2e-40 2.4e-40
14 PL gene expression Ccs 0.4 0.13 0.0e+00 0.42 0.43 0.43 0.43 4.5e-49 1.5e-51 8.1e-51 5.3e-51
15 Brain gene expression Ccs 0.33 0.06 0.0e+00 0.42 0.44 0.44 0.44 8.1e-42 1.3e-44 2.9e-45 1.8e-45
16 Liver alternative polyA NM_053425.1 0.18 0.09 2.5e-14 0.1 0.11 0.1 0.11 3.9e-11 6.3e-12 6.4e-11 4.3e-12
17 NAcc isoform ratio NM_053425.1 0.03 0.02 5.5e-04 0.02 0.01 0.02 0.01 1.1e-03 6.8e-03 1.5e-03 2.2e-03
18 NAcc isoform ratio XM_039092800.2 0.03 0.02 8.0e-04 0.02 0.01 0.01 0.01 1.3e-03 9.5e-03 1.9e-03 2.6e-03
19 Liver alternative polyA XM_039092800.2 0.17 0.08 3.2e-14 0.1 0.11 0.1 0.11 4.6e-11 2.6e-12 2.0e-11 2.1e-12
20 BLA intron excision ratio chr1_211543837_211555856 0.06 0.05 5.3e-03 0.01 0.01 -0 0 7.2e-02 8.3e-02 7.9e-01 1.7e-01
21 BLA intron excision ratio chr1_211555916_211556368 0.07 0.06 4.5e-03 0.03 0.01 -0 0.01 1.5e-02 9.7e-02 7.1e-01 9.6e-02
22 RMTg gene expression Ccs 0.35 0.14 2.6e-08 0.16 0.28 0.25 0.25 6.2e-05 3.4e-08 2.9e-07 2.4e-07
23 Eye isoform ratio NM_053425.1 0.63 0.3 7.8e-03 -0.01 -0.02 0.08 -0.02 6.2e-01 6.5e-01 2.5e-02 7.4e-01
24 Eye isoform ratio XM_039092800.2 0.73 0.22 8.3e-03 -0 -0.02 0.08 -0.02 3.9e-01 7.9e-01 2.3e-02 9.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bone: apparent density1.73.27.40.50.8-0.91.4-1.5-1.5-1.4-1.31.7-1.01.61.91.71.71.81.8-2.22.7-1.8-2.72.72.5-1.71.5
Area under the delay curve0.81.34.81.10.8-0.90.9-1.0-1.0-0.7-1.21.1-0.51.00.81.01.01.11.0-0.51.1-1.0-1.11.11.0-2.22.1
BMI with tail1.86.222.1-0.60.2-0.31.2-1.3-1.3-1.2-1.11.7-0.71.72.01.81.92.12.4-3.74.7-2.5-4.54.53.6-3.03.0
BMI without tail0.42.211.9-0.9-0.20.10.1-0.3-0.3-0.2-0.40.50.00.70.60.70.80.81.1-2.03.4-1.1-2.92.92.0-2.32.2
Body weight0.72.99.2-2.8-2.22.1-1.41.41.41.61.3-1.01.9-0.9-0.6-0.9-0.8-0.7-0.4-2.13.00.3-2.72.71.2-1.41.6
Weight adjusted by age0.41.22.5-1.5-1.61.6-1.31.21.21.31.5-1.11.4-1.2-0.9-1.2-1.1-1.1-1.1-0.50.31.0-0.10.1-0.41.0-0.9
Bone surface1.22.310.2-1.3-0.80.70.4-0.4-0.4-0.1-0.40.80.20.51.30.60.71.21.1-3.23.0-1.2-2.92.92.3-1.11.2
Bone volume1.12.26.3-0.10.1-0.21.1-1.1-1.1-0.8-0.91.3-0.51.11.71.21.21.51.4-2.52.4-1.5-2.52.52.3-1.11.0
Breakpoint value in progressive ratio session0.50.92.4-1.6-1.51.5-1.10.90.90.91.1-0.71.0-0.9-0.3-0.8-0.7-0.5-0.6-1.31.00.6-0.90.90.30.9-0.8
Number of licking bursts0.00.10.30.0-0.40.40.0-0.0-0.00.3-0.00.10.2-0.10.1-0.1-0.10.2-0.1-0.5-0.00.1-0.30.30.3-0.30.3
Context. condit. distance diff. score0.50.72.21.51.3-1.20.8-0.9-0.9-1.1-0.60.7-1.20.80.50.80.80.40.50.3-0.2-0.50.5-0.50.00.8-0.7
Locomotion velocity, session 10.30.40.90.1-0.50.5-0.50.50.50.80.5-0.60.9-0.6-0.9-0.7-0.7-0.6-0.70.7-0.60.70.5-0.5-0.8-0.0-0.0
Locomotion distance, session 10.91.13.60.40.2-0.30.8-0.7-0.7-0.4-0.80.8-0.10.80.80.80.80.90.9-1.21.7-0.9-1.91.91.4-1.71.7
Locomotion velocity, session 20.70.81.9-1.4-1.31.2-0.80.90.91.00.9-0.71.2-0.7-0.6-0.7-0.6-0.6-0.4-0.71.30.3-1.41.40.4-0.60.7
Locomotion distance, session 20.50.72.7-0.3-0.30.20.1-0.0-0.00.2-0.30.10.60.20.10.20.20.20.4-0.81.6-0.4-1.61.60.9-1.61.7
Locomotion velocity, session 30.50.61.10.70.7-0.70.8-0.8-0.8-0.7-0.70.8-0.60.80.70.80.80.70.9-0.80.3-0.9-0.70.70.8-1.01.1
Locomotion distance, session 30.00.00.10.20.1-0.10.1-0.1-0.1-0.00.10.10.10.10.00.10.1-0.10.1-0.1-0.3-0.20.1-0.10.0-0.40.4
Stereotopy head waving bouts, day 30.80.91.51.01.2-1.20.8-0.9-0.9-1.1-1.00.8-1.01.10.71.01.00.71.1-0.10.8-1.1-0.80.80.8-1.21.1
Stereotopy head waving duration, day 31.01.32.11.21.4-1.41.1-1.2-1.2-1.4-1.41.2-1.41.31.01.31.31.01.2-0.20.5-1.2-0.60.60.9-1.11.0
Locomotion velocity, session 70.80.92.80.50.9-0.90.8-0.8-0.8-1.1-0.80.9-1.11.00.81.01.00.81.0-0.81.7-1.0-1.01.01.1-0.20.1
Locomotion distance, session 70.10.11.6-0.20.0-0.1-0.10.10.1-0.10.1-0.10.00.2-0.20.10.1-0.10.2-0.31.3-0.2-0.70.70.4-0.30.3
Stereotopy head waving bouts, day 71.01.22.00.50.9-0.91.0-1.2-1.2-1.3-0.71.2-1.21.11.41.21.21.21.4-1.30.4-1.4-0.80.81.2-0.60.5
Stereotopy head waving duration, day 70.81.03.2-0.50.2-0.30.6-0.7-0.7-1.0-0.30.9-0.70.81.20.90.90.91.2-1.80.9-1.2-1.41.41.5-0.80.8
Locomotion velocity, session 80.70.81.7-1.1-1.21.2-0.91.11.11.21.0-1.01.3-1.0-1.0-1.0-1.0-1.0-0.90.10.30.9-0.20.2-0.50.00.1
Locomotion distance, session 80.30.41.21.10.7-0.70.9-0.8-0.8-0.7-0.60.7-0.60.70.60.70.60.50.6-0.20.6-0.6-0.30.30.40.00.0
Degree of sensitization distance0.30.32.5-0.10.2-0.30.2-0.2-0.2-0.4-0.40.3-0.30.50.20.40.40.40.5-0.61.6-0.5-1.01.00.7-0.30.3
Degree of sensitization stereotypy0.30.31.8-0.5-0.0-0.00.3-0.4-0.4-0.60.20.5-0.50.40.90.50.50.60.8-1.30.3-0.8-0.70.70.90.1-0.1
Conditioned locomotion1.61.93.5-1.9-1.71.7-1.61.71.71.61.7-1.71.6-1.5-1.5-1.5-1.5-1.5-1.50.20.41.40.0-0.0-0.70.9-0.8
Cocaine response after cond. corrected0.10.20.80.70.7-0.70.3-0.3-0.3-0.4-0.20.2-0.50.30.00.30.30.00.00.9-0.6-0.00.6-0.6-0.30.3-0.4
Cocaine response after cond. not corrected0.20.30.70.80.8-0.80.6-0.6-0.6-0.6-0.50.5-0.70.50.40.50.50.40.30.4-0.6-0.30.4-0.4-0.0-0.0-0.1
Cocaine response before conditioning0.10.21.0-0.1-0.30.30.2-0.3-0.30.1-0.40.40.10.00.50.10.10.50.3-1.0-0.0-0.3-0.50.50.5-0.60.6
Saline control response0.91.22.6-1.4-1.61.5-1.10.80.81.31.0-0.61.5-0.9-0.6-0.9-0.8-0.5-0.5-1.01.40.5-1.61.60.4-1.01.1
Bone: connectivity density1.62.510.7-0.7-0.20.10.7-0.7-0.7-0.6-0.61.0-0.30.91.31.01.11.31.3-2.83.3-1.4-3.13.12.4-1.41.5
Bone: cortical apparent density0.40.71.1-0.7-0.80.8-1.00.90.90.80.9-0.90.8-0.9-1.0-0.9-0.9-0.9-0.90.8-1.00.90.6-0.6-0.80.2-0.3
Bone: cortical area0.40.71.3-0.9-1.21.1-0.80.80.81.00.9-0.81.0-1.0-0.6-0.9-0.9-0.7-0.9-0.20.00.90.3-0.3-0.51.1-0.9
Bone: cortical porosity0.50.51.90.10.3-0.30.5-0.5-0.5-0.4-0.20.6-0.20.60.60.60.60.50.7-0.70.5-0.7-1.11.10.9-1.41.4
Bone: cortical porosity0.30.31.4-0.3-0.10.00.1-0.1-0.1-0.00.10.10.20.30.20.20.30.10.3-0.60.7-0.3-1.21.20.7-1.11.1
Bone: cortical thickness4.16.910.6-3.0-3.23.2-3.13.13.13.13.1-3.03.1-3.0-2.8-3.0-3.0-2.8-2.80.8-0.72.70.9-0.9-2.01.6-1.4
Bone: cortical thickness2.12.64.3-1.5-1.71.8-1.92.02.02.01.7-2.01.9-1.8-2.1-1.8-1.8-1.9-1.71.2-0.71.70.5-0.5-1.4-0.20.2
Bone: cortical tissue density0.60.91.5-0.9-1.01.0-1.21.11.11.01.1-1.10.9-1.1-1.1-1.0-1.0-1.0-1.00.8-1.01.00.5-0.5-0.90.2-0.3
Condit. Reinf. active minus inactive responses0.20.20.8-0.0-0.10.10.3-0.4-0.40.0-0.20.40.10.20.50.30.30.40.5-0.90.6-0.5-0.80.80.6-0.60.7
Condit. Reinf. active-inactive response ratio0.20.20.50.10.1-0.10.3-0.4-0.4-0.1-0.50.5-0.10.30.60.30.30.60.5-0.70.2-0.5-0.40.40.5-0.50.5
Condit. Reinf. active responses0.10.10.40.0-0.10.10.2-0.3-0.30.1-0.20.30.20.10.40.20.20.30.3-0.70.6-0.3-0.60.60.5-0.20.3
Condit. Reinf. inactive responses0.00.00.20.30.2-0.20.3-0.2-0.2-0.2-0.10.2-0.10.20.20.20.20.10.1-0.10.4-0.1-0.20.20.20.1-0.1
Incentive salience index mean0.20.31.4-0.1-0.20.20.2-0.3-0.3-0.0-0.00.40.10.20.40.20.30.40.4-0.91.2-0.4-1.11.10.7-0.50.5
Condit. Reinf. lever presses0.10.11.1-0.3-0.50.5-0.20.10.10.30.6-0.10.4-0.30.1-0.2-0.2-0.1-0.2-0.21.00.2-0.40.40.20.4-0.5
Condit. Reinf. active minus inactive responses1.01.62.91.11.1-1.11.6-1.5-1.5-1.3-1.61.6-1.21.31.71.31.31.51.4-0.90.5-1.4-0.40.41.2-1.10.9
Condit. Reinf. active-inactive response ratio1.11.73.21.61.4-1.41.8-1.7-1.7-1.5-1.71.7-1.51.31.81.41.41.61.4-0.40.1-1.30.2-0.20.9-0.40.3
Condit. Reinf. active responses1.62.24.40.70.9-1.01.5-1.5-1.5-1.4-1.51.6-1.11.41.81.51.51.61.7-1.61.2-1.7-1.41.41.8-2.12.0
Condit. Reinf. inactive responses0.91.35.7-0.50.2-0.20.4-0.4-0.4-0.6-0.40.5-0.30.70.60.70.80.61.0-1.31.3-1.0-2.02.01.4-2.42.4
Condit. Reinf. lever presses0.50.72.6-1.0-0.70.6-0.0-0.2-0.2-0.0-0.00.30.30.10.70.20.20.40.7-1.31.4-0.7-1.21.21.1-1.61.5
Condit. Reinf. lever reinforcers received1.31.84.80.40.6-0.71.2-1.3-1.3-1.1-1.21.4-0.91.21.61.21.21.31.5-1.41.2-1.5-1.41.41.6-2.22.1
Conditioned reinforcement - actives0.10.21.90.3-0.20.2-0.00.10.1-0.1-0.0-0.10.1-0.3-0.0-0.2-0.2-0.1-0.3-0.1-0.70.30.7-0.7-0.41.4-1.3
Conditioned reinforcement - inactives0.61.73.81.91.7-1.71.7-1.7-1.7-1.8-1.51.5-1.61.31.41.31.21.21.1-0.0-1.1-1.01.1-1.10.20.1-0.0
Conditioned locomotion2.03.08.52.92.5-2.42.1-2.0-2.0-1.9-2.01.7-1.91.51.21.41.31.20.91.4-1.9-0.82.0-2.0-0.50.3-0.4
Patch foraging indifference point 0 sec0.20.61.60.90.7-0.70.9-0.9-0.9-0.6-1.30.9-0.70.80.90.80.81.10.8-0.80.1-0.8-0.40.40.6-0.70.9
Patch foraging indifference point AUC0.81.85.4-2.3-1.81.7-1.61.71.71.21.7-1.41.3-1.4-1.0-1.3-1.2-1.3-1.0-0.50.21.0-0.10.1-0.41.7-1.6
Delay disc. indifference point, 0s delay1.31.57.11.11.2-1.21.2-1.2-1.2-1.0-0.91.0-0.81.20.71.11.10.81.00.31.1-1.0-1.01.00.9-2.72.5
Delay disc. indifference point, 16s delay1.21.72.81.41.3-1.31.4-1.6-1.6-1.4-1.61.7-1.31.31.41.31.31.51.4-0.50.3-1.4-0.40.41.0-1.21.1
Delay disc. indifference point, 2s delay0.60.71.71.10.8-0.81.0-0.9-0.9-0.7-0.80.9-0.60.80.80.80.80.80.8-0.20.4-0.8-0.50.50.6-1.31.2
Delay disc. indifference point, 24s delay0.10.20.50.5-0.20.2-0.60.50.50.60.2-0.40.5-0.3-0.7-0.4-0.4-0.3-0.50.7-0.20.50.2-0.2-0.5-0.40.4
Delay disc. indifference point, 4s delay0.70.84.40.70.7-0.70.6-0.7-0.7-0.6-0.90.8-0.30.70.30.70.70.60.70.11.0-0.6-1.01.00.7-2.11.9
Delay disc. indifference point, 8s delay0.30.62.80.90.5-0.60.4-0.5-0.5-0.4-0.90.6-0.20.60.30.60.60.60.6-0.00.9-0.6-0.80.80.6-1.71.6
Indifference point function ln k1.02.911.93.42.6-2.51.9-2.0-2.0-1.5-2.11.5-1.61.50.81.31.21.00.81.9-1.3-0.71.5-1.5-0.6-1.11.0
Indifference point function log k1.02.911.93.42.6-2.51.9-2.0-2.0-1.5-2.11.5-1.61.50.81.31.21.00.81.9-1.3-0.71.5-1.5-0.6-1.11.0
Patch foraging total patch changes 0 sec0.00.10.60.60.2-0.20.2-0.3-0.30.0-0.60.2-0.10.10.10.10.10.30.1-0.3-0.3-0.10.0-0.0-0.1-0.50.7
Patch foraging total patch changes 12 sec1.21.65.4-2.3-1.81.7-1.61.41.41.01.5-1.21.1-1.0-0.7-0.9-0.9-0.8-0.5-1.51.40.5-1.61.60.50.10.1
Patch foraging total patch changes 18 sec0.10.32.0-0.9-0.40.4-0.30.30.3-0.10.0-0.10.00.00.10.00.10.20.3-1.40.7-0.3-0.90.90.60.4-0.2
Patch foraging total patch changes 24 sec0.41.32.6-1.6-1.61.6-1.31.51.51.31.2-1.41.3-1.3-1.1-1.3-1.2-1.1-1.1-0.40.11.1-0.20.2-0.50.7-0.5
Patch foraging total patch changes 6 sec0.30.52.4-1.3-0.80.8-0.50.40.40.30.4-0.30.4-0.2-0.0-0.2-0.1-0.10.2-1.51.0-0.2-1.31.30.7-0.40.6
Patch foraging time to switch 0 sec0.51.86.1-0.7-0.20.10.4-0.7-0.7-0.5-0.50.9-0.30.81.20.91.01.21.1-2.42.4-1.2-2.52.52.1-1.41.5
Patch foraging water rate 0 sec0.62.29.32.00.9-0.80.3-0.2-0.2-0.1-0.2-0.2-0.4-0.3-0.6-0.4-0.5-0.6-0.92.7-2.81.03.0-3.0-2.21.8-1.8
Patch foraging water rate 12 sec0.72.713.22.91.8-1.70.8-0.6-0.6-0.5-0.60.1-0.80.2-0.70.0-0.1-0.5-0.73.6-3.00.83.0-3.0-2.20.5-0.6
Patch foraging water rate 18 sec0.40.83.92.01.1-1.00.6-0.6-0.6-0.3-0.40.3-0.50.3-0.20.10.1-0.1-0.21.7-1.70.31.5-1.5-1.0-0.50.4
Patch foraging water rate 24 sec1.21.76.52.01.0-0.90.1-0.1-0.1-0.10.0-0.2-0.4-0.2-0.7-0.3-0.4-0.5-0.82.4-2.40.92.5-2.5-1.91.4-1.4
Patch foraging water rate 6 sec1.11.67.51.80.8-0.70.20.00.00.3-0.1-0.50.2-0.3-0.9-0.5-0.6-0.9-1.02.7-2.31.12.5-2.5-2.10.7-0.6
Seeking ratio, delayed vs. immediate footshock1.11.65.91.10.9-0.91.2-1.2-1.2-0.9-1.41.3-0.61.11.11.11.11.31.1-0.80.7-1.1-1.11.11.2-2.32.4
Distance traveled before self-admin0.20.41.00.10.1-0.10.4-0.5-0.5-0.3-0.50.6-0.40.40.70.50.50.80.6-1.00.9-0.6-0.90.90.9-0.50.5
Distance traveled after self-admin0.00.10.3-0.2-0.10.10.1-0.2-0.20.10.10.1-0.00.00.30.10.10.20.2-0.60.2-0.3-0.30.30.3-0.30.3
Extensor digitorum longus weight3.012.030.0-5.5-5.15.0-4.24.14.14.24.3-3.64.6-3.7-2.9-3.6-3.4-3.2-2.7-1.22.82.6-1.51.5-0.60.6-0.4
Bone: elastic displacement1.51.84.40.1-0.60.7-1.01.21.21.21.1-1.41.0-1.3-1.6-1.3-1.4-1.4-1.52.1-1.71.51.9-1.9-1.90.9-0.9
Bone: elastic work2.33.04.5-1.5-2.02.0-2.02.12.12.12.0-2.12.0-2.0-2.1-2.0-2.0-2.0-1.91.2-0.21.90.7-0.7-1.60.5-0.5
Bone: endosteal estimation1.94.56.72.62.3-2.42.5-2.6-2.6-2.2-2.52.5-2.12.42.42.42.32.42.2-1.11.7-2.2-1.21.21.8-1.11.1
Bone: endosteal perimeter3.27.812.43.02.9-2.93.4-3.4-3.4-2.9-3.53.4-2.83.03.43.13.03.33.0-2.11.8-2.9-1.21.22.4-0.80.8
Epididymis fat weight1.05.213.53.73.2-3.12.7-2.8-2.8-2.8-2.42.4-3.02.22.02.22.11.91.61.2-1.7-1.51.9-1.90.10.4-0.7
Delta time in closed arm before/after self-admin0.90.91.8-1.0-0.90.9-1.31.21.20.91.2-1.30.9-0.9-1.3-1.0-0.9-1.2-0.90.40.40.9-0.40.4-0.50.3-0.2
Delta time in open arm before/after self-admin0.20.22.5-0.5-0.20.2-0.00.00.0-0.00.40.1-0.2-0.10.4-0.0-0.00.10.0-0.5-0.3-0.10.3-0.30.11.5-1.6
Diff in mean of infusions in LGA sessions0.40.83.3-1.2-1.01.0-1.11.01.00.70.6-0.80.6-0.8-0.7-0.8-0.7-0.6-0.8-0.20.10.8-0.10.1-0.31.8-1.8
Delay discount exponential model param0.70.94.1-1.1-0.60.7-0.60.80.80.61.1-0.90.4-0.8-0.6-0.8-0.8-0.9-0.80.4-1.00.81.0-1.0-0.92.0-1.9
Extinction: sum of active levers before priming0.40.52.9-0.9-0.80.8-0.30.30.30.20.4-0.00.3-0.10.3-0.1-0.00.20.1-1.41.7-0.1-1.41.41.00.5-0.5
Active lever presses in extinction session 61.11.13.8-1.9-1.61.5-1.11.11.11.21.7-1.01.1-1.1-0.5-1.0-0.9-0.9-0.8-1.10.00.8-0.20.2-0.10.8-0.5
Bone: final force0.50.82.1-1.2-1.51.4-1.00.90.91.11.0-0.81.3-0.9-0.5-0.8-0.8-0.7-0.6-0.91.40.6-0.80.80.20.2-0.0
Bone: final moment0.50.71.9-1.1-1.41.3-0.80.80.81.10.9-0.71.3-0.8-0.5-0.8-0.7-0.6-0.6-0.91.30.5-0.80.80.20.10.1
Food consumed during 24 hour testing period0.10.31.3-0.2-0.40.4-0.50.20.20.30.5-0.20.3-0.5-0.2-0.5-0.5-0.4-0.40.7-1.10.41.0-1.0-0.60.1-0.2
Glucose3.45.47.82.62.8-2.82.7-2.7-2.7-2.6-2.82.6-2.42.72.42.62.62.52.5-0.90.7-2.5-1.11.11.9-1.71.6
Heart weight2.64.37.21.82.1-2.22.0-2.1-2.1-2.1-1.92.1-2.02.31.82.22.22.02.2-0.91.6-2.1-1.91.92.0-2.72.6
Delay discount hyperbolic model param0.81.04.2-1.1-0.70.7-0.80.90.90.61.2-1.00.4-0.9-0.7-0.8-0.8-1.0-0.90.4-1.00.91.0-1.0-0.92.0-1.9
Intermittent access intake day 1-15 change0.10.52.00.80.8-0.70.6-0.6-0.6-0.7-0.40.4-0.70.30.40.30.30.30.20.9-1.4-0.11.4-1.4-0.50.5-0.6
Intermittent access intake escalation0.10.52.30.60.6-0.50.4-0.4-0.4-0.5-0.30.2-0.50.10.30.10.10.20.00.8-1.40.01.5-1.5-0.60.9-0.9
Intermittent access intake escalation 20.40.62.40.70.6-0.60.4-0.4-0.4-0.5-0.30.2-0.60.10.20.10.10.2-0.00.7-1.50.11.6-1.6-0.71.6-1.6
Intermitt. access day 1 inactive lever presses0.00.10.30.10.2-0.20.2-0.3-0.3-0.3-0.30.2-0.30.10.30.20.20.30.20.1-0.3-0.20.5-0.5-0.00.3-0.5
Intermitt. access day 15 inactive lever presses0.31.52.51.11.5-1.41.4-1.5-1.5-1.6-1.51.4-1.41.31.61.41.31.41.4-0.5-0.2-1.40.4-0.40.8-0.40.3
Intermitt. access escalation Index0.61.84.82.22.1-2.01.6-1.6-1.6-1.6-1.71.4-1.61.61.01.51.41.11.10.6-0.1-1.00.2-0.20.5-0.1-0.0
Intermittent access day 1 total infusions2.47.110.42.72.9-2.93.2-3.1-3.1-3.2-2.93.2-2.83.02.93.03.02.92.8-1.61.4-2.8-1.41.42.5-1.81.7
Intermittent access day 15 total infusions1.74.27.72.82.6-2.62.6-2.6-2.6-2.7-2.32.4-2.62.22.22.22.12.11.9-0.2-0.6-1.80.6-0.61.0-0.20.0
Intermittent access terminal intake (last 3 days)2.74.78.52.62.7-2.62.8-2.7-2.7-2.9-2.42.7-2.72.42.52.42.42.42.2-0.8-0.2-2.20.1-0.11.4-0.20.1
Intermittent access total infusions4.25.08.22.52.6-2.62.8-2.7-2.7-2.9-2.52.7-2.62.52.62.52.52.42.4-1.20.6-2.3-0.60.61.8-1.00.9
Intermittent access day 1 locomotion2.44.46.22.02.3-2.32.4-2.4-2.4-2.5-2.32.4-2.22.32.32.32.32.32.3-1.31.1-2.2-1.01.01.9-1.71.6
Intermittent access day 15 total locomotion1.24.67.82.62.6-2.62.8-2.7-2.7-2.8-2.42.6-2.62.32.52.32.32.32.2-0.5-0.4-2.10.3-0.31.3-0.80.7
Intermittent access total locomotion7.18.613.73.43.5-3.53.7-3.7-3.7-3.7-3.43.6-3.33.23.33.23.23.23.1-1.10.2-3.0-0.20.22.0-1.71.5
Intermittent access standard deviation0.10.31.20.80.8-0.70.6-0.6-0.6-0.7-0.30.4-0.60.40.30.40.30.20.30.5-1.0-0.21.1-1.1-0.40.1-0.2
Left kidney weight0.11.23.71.91.7-1.61.3-1.3-1.3-1.4-1.11.1-1.41.10.71.00.90.60.61.30.0-0.50.8-0.8-0.1-0.1-0.1
Right kidney weight0.10.64.01.40.8-0.70.5-0.5-0.5-0.4-0.40.3-0.50.2-0.00.10.0-0.1-0.32.0-1.10.41.5-1.5-0.9-0.2-0.1
Cocaine induced anxiety0.00.00.3-0.2-0.00.00.1-0.1-0.1-0.20.10.1-0.00.00.30.10.10.10.2-0.5-0.1-0.20.2-0.20.10.3-0.2
Post-drug Anxiety0.20.20.6-0.7-0.70.7-0.50.40.40.30.5-0.40.5-0.5-0.2-0.4-0.4-0.4-0.2-0.60.10.2-0.00.0-0.00.8-0.6
Baseline Anxiety0.20.40.7-0.5-0.70.7-0.80.80.80.70.5-0.80.6-0.7-0.8-0.7-0.7-0.8-0.70.5-0.20.7-0.00.0-0.50.6-0.5
Tail length0.73.85.8-2.0-2.12.1-2.32.32.32.42.1-2.42.4-2.2-2.3-2.2-2.2-2.3-2.21.2-0.32.20.9-0.9-1.71.0-0.8
Length with tail1.67.012.2-3.5-3.33.3-3.13.33.33.33.1-3.13.4-2.9-2.8-2.9-2.9-2.9-2.70.40.12.70.3-0.3-1.61.3-1.0
Length without tail0.94.98.6-2.9-2.92.9-2.62.72.72.82.7-2.62.9-2.5-2.3-2.5-2.4-2.4-2.20.3-0.42.2-0.00.0-1.30.4-0.2
Times rat made contact with spout0.20.21.4-0.4-0.40.3-0.10.20.20.30.1-0.00.30.0-0.1-0.00.00.10.1-0.81.2-0.1-1.01.00.5-0.40.5
Lifetime Intake3.03.76.42.22.2-2.22.4-2.3-2.3-2.5-2.02.3-2.22.22.22.22.22.02.0-1.10.8-2.0-0.80.81.7-0.90.8
Liver weight, left0.30.52.40.70.3-0.3-0.20.30.30.20.3-0.50.1-0.3-0.8-0.4-0.4-0.6-0.71.5-0.90.71.0-1.0-1.00.9-1.0
Liver weight, right0.30.63.31.71.2-1.10.6-0.6-0.6-0.4-0.60.4-0.50.5-0.20.40.40.1-0.01.8-0.90.10.6-0.6-0.5-0.80.5
Locomotor activity0.50.84.31.40.4-0.4-0.00.00.00.4-0.0-0.30.3-0.3-0.9-0.4-0.5-0.6-0.72.1-1.50.81.4-1.4-1.4-0.1-0.0
Locomotor testing distance0.30.84.81.60.6-0.60.2-0.1-0.10.3-0.1-0.30.3-0.2-0.9-0.4-0.5-0.6-0.82.2-1.50.81.5-1.5-1.50.1-0.1
Locomotor testing rearing0.20.72.91.71.4-1.40.9-0.9-0.9-0.8-0.90.6-0.70.90.10.70.70.40.51.1-0.6-0.40.4-0.4-0.2-0.70.6
Locomotion in novel chamber2.12.88.42.92.4-2.32.1-2.1-2.1-1.9-2.11.8-1.91.71.41.61.51.51.30.9-1.3-1.21.1-1.10.1-0.40.3
Locomotion in novel chamber post-restriction0.51.64.32.11.8-1.81.6-1.6-1.6-1.6-1.31.3-1.71.31.11.21.21.11.00.6-1.0-1.00.7-0.70.10.0-0.2
Fecal boli incidents, locomotor time 10.10.33.3-0.6-0.00.1-0.1-0.1-0.1-0.20.5-0.0-0.4-0.10.20.00.00.00.1-0.5-0.4-0.20.6-0.6-0.11.6-1.8
Change in fecal boli incidents, locomotor task0.40.53.60.70.3-0.30.5-0.3-0.3-0.1-0.80.4-0.00.40.10.30.30.40.3-0.10.7-0.3-0.70.70.4-1.81.9
Time >=10cm from walls, locomotor time 13.44.26.01.91.9-1.92.3-2.3-2.3-2.2-2.42.4-1.92.12.52.22.22.42.2-1.70.9-2.2-0.70.71.9-2.12.1
Bouts of movement, locomotor time 10.30.41.5-1.2-1.11.1-0.80.70.70.80.7-0.60.8-0.8-0.3-0.7-0.6-0.4-0.5-0.6-0.10.50.1-0.1-0.10.5-0.5
Total resting periods, locomotor time 10.10.20.9-0.9-0.70.7-0.40.30.30.40.3-0.20.4-0.40.0-0.3-0.3-0.0-0.1-0.80.00.10.1-0.10.10.4-0.4
Rest time, locomotor task time 10.50.72.51.61.0-1.00.9-0.9-0.9-0.6-1.30.7-0.60.50.50.50.40.60.30.7-1.2-0.31.3-1.3-0.50.1-0.1
Distance moved, locomotor task time 10.30.92.8-0.20.3-0.30.5-0.5-0.5-0.7-0.30.7-0.40.70.80.80.80.61.0-1.21.3-1.0-1.51.51.3-1.61.7
Vertical activity count, locomotor time 10.00.20.50.50.6-0.60.2-0.3-0.3-0.6-0.30.3-0.60.40.10.40.40.20.30.5-0.2-0.30.1-0.10.0-0.70.6
Time >=10cm from walls, locomotor time 20.10.20.60.50.2-0.20.3-0.5-0.5-0.3-0.80.6-0.30.20.60.30.30.60.3-0.60.1-0.30.3-0.30.20.3-0.2
Bouts of movement, locomotor time 20.00.21.0-1.0-0.50.5-0.40.40.40.10.6-0.30.2-0.2-0.1-0.1-0.1-0.1-0.0-0.60.5-0.0-0.40.40.40.3-0.4
Total resting periods, locomotor time 20.00.10.4-0.6-0.20.1-0.10.10.1-0.20.30.0-0.10.10.20.20.20.20.3-0.60.6-0.3-0.50.50.50.3-0.5
Rest time, locomotor task time 20.50.82.31.51.4-1.41.0-1.0-1.0-1.1-1.20.8-1.10.90.60.90.80.60.70.6-0.6-0.70.7-0.7-0.0-0.1-0.1
Distance moved, locomotor task time 20.40.51.4-1.1-1.21.2-0.90.80.80.90.6-0.71.0-0.8-0.5-0.8-0.8-0.6-0.7-0.20.10.7-0.20.2-0.2-0.40.5
Vertical activity count, locomotor time 20.81.92.9-0.7-1.21.2-1.61.51.51.41.3-1.41.3-1.5-1.6-1.5-1.5-1.5-1.71.6-1.31.71.2-1.2-1.60.4-0.4
Light reinforcement 10.00.10.50.70.3-0.30.3-0.3-0.30.0-0.30.2-0.10.1-0.10.10.00.0-0.20.5-0.30.20.1-0.1-0.2-0.50.4
Light reinforcement 20.30.61.21.00.9-0.91.1-0.9-0.9-0.8-0.91.0-0.90.60.80.60.60.70.50.3-0.5-0.50.9-0.9-0.10.5-0.7
Bone: marrow area1.94.76.92.62.4-2.42.5-2.6-2.6-2.3-2.62.6-2.22.42.42.42.42.42.2-1.11.8-2.2-1.21.21.9-1.01.0
Bone: maximum diameter0.10.21.10.4-0.00.00.4-0.4-0.4-0.1-0.40.4-0.10.10.60.20.10.40.0-0.50.0-0.00.4-0.40.11.1-0.9
Bone: maximum force0.51.05.2-1.1-1.00.9-0.0-0.0-0.00.4-0.00.30.6-0.00.70.10.10.50.5-2.32.3-0.6-1.81.81.4-0.70.9
Bone: maximum moment0.51.04.7-1.0-1.00.90.0-0.0-0.00.4-0.00.30.6-0.00.70.10.10.50.5-2.22.1-0.6-1.71.71.3-0.81.0
Mean time between licks in bursts0.10.40.9-0.2-0.70.7-0.70.60.60.90.6-0.60.9-0.6-0.8-0.7-0.7-0.7-0.70.2-0.00.7-0.20.2-0.4-0.40.5
Mean num. licks in bursts0.00.10.5-0.00.5-0.50.2-0.1-0.1-0.4-0.20.1-0.30.40.00.30.30.10.40.00.7-0.3-0.30.30.20.00.0
Cd content in liver0.91.02.21.51.3-1.31.3-1.2-1.2-1.1-1.01.1-1.41.01.01.01.01.00.9-0.0-1.0-0.90.3-0.30.4-0.20.2
Co content in liver1.51.85.40.4-0.30.3-0.91.11.10.90.7-1.30.8-1.1-1.7-1.2-1.3-1.5-1.42.3-1.71.51.9-1.9-2.01.2-1.3
Cu content in liver0.30.41.90.10.3-0.30.4-0.4-0.4-0.5-0.30.4-0.40.50.40.50.50.40.7-0.30.5-0.6-0.70.70.6-1.41.3
Fe content in liver0.40.51.0-0.7-0.70.8-0.90.80.80.71.0-0.80.6-0.8-0.9-0.8-0.8-0.8-0.70.3-0.30.70.3-0.3-0.60.5-0.5
K content in liver0.30.20.9-0.3-0.30.2-0.00.00.00.10.00.10.20.10.10.10.10.20.3-0.71.0-0.4-1.01.00.6-0.90.9
Mg content in liver0.60.72.10.80.8-0.90.9-0.9-0.9-0.7-0.90.8-0.70.90.70.80.80.81.0-0.30.1-1.0-0.40.40.7-1.41.3
Mn content in liver0.80.94.2-2.0-1.61.5-1.01.01.00.91.3-0.71.0-0.9-0.3-0.8-0.7-0.5-0.4-1.40.30.3-0.50.50.30.6-0.5
Na content in liver0.80.91.2-0.5-1.01.0-0.80.80.81.00.7-0.80.9-1.1-0.8-1.1-1.1-0.8-1.01.0-0.91.01.1-1.1-1.10.6-0.7
Rb content in liver1.31.52.61.31.6-1.61.4-1.3-1.3-1.4-1.51.2-1.31.41.01.31.31.21.4-0.20.4-1.4-0.50.50.8-1.21.1
Se content in liver0.40.40.80.40.6-0.60.7-0.8-0.8-0.9-0.50.8-0.90.70.90.70.70.70.9-0.70.0-0.8-0.10.10.60.00.0
Sr content in liver2.11.83.3-1.8-1.71.7-1.61.61.61.61.6-1.51.5-1.6-1.3-1.5-1.5-1.3-1.40.2-0.81.40.5-0.5-0.90.8-0.8
Zn content in liver0.20.20.4-0.6-0.50.4-0.50.50.50.30.5-0.50.4-0.3-0.4-0.3-0.3-0.4-0.10.20.50.2-0.50.50.0-0.60.6
Bone: minimum diameter3.16.08.22.32.4-2.42.7-2.8-2.8-2.5-2.92.8-2.32.72.82.72.72.82.7-1.92.1-2.7-1.71.72.4-1.51.6
Time in familiar zone, hab. session 10.70.81.50.90.9-0.91.2-1.1-1.1-0.8-1.11.1-0.80.91.10.90.91.01.0-0.50.2-1.0-0.40.40.8-1.00.9
Time in novel zone, hab. session 10.40.40.8-0.2-0.20.3-0.80.60.60.50.6-0.70.5-0.6-0.9-0.6-0.6-0.8-0.80.8-0.70.80.7-0.7-0.90.6-0.4
Total zone transitions, hab. session 10.20.30.9-0.6-0.70.6-0.30.20.20.60.3-0.10.7-0.3-0.0-0.2-0.2-0.10.0-0.80.9-0.0-0.80.80.4-0.40.6
Total locomotion distance, hab. session 10.30.41.11.00.8-0.80.8-0.8-0.8-0.5-1.00.8-0.60.70.70.70.70.80.6-0.30.4-0.6-0.10.10.40.2-0.1
Locomotion velocity, hab. session 10.10.10.40.60.3-0.30.4-0.4-0.4-0.1-0.60.4-0.20.40.40.30.40.40.3-0.40.7-0.3-0.20.20.30.3-0.2
Time in familiar zone, hab. session 20.50.51.0-0.7-0.60.6-0.80.90.90.80.8-0.90.7-0.7-1.0-0.8-0.8-0.9-0.80.6-0.60.70.5-0.5-0.70.4-0.5
Time in novel zone, hab. session 20.70.71.10.40.6-0.60.8-0.8-0.8-0.8-0.90.9-0.60.80.90.80.80.90.9-0.81.0-0.9-0.90.91.0-1.01.1
Total zone transitions, hab. session 23.03.810.80.30.6-0.71.4-1.3-1.3-1.0-1.41.5-0.71.61.71.61.71.82.0-2.82.8-2.1-3.33.32.6-2.52.7
Total locomotion distance, hab. session 21.82.33.61.21.2-1.21.5-1.4-1.4-1.1-1.71.5-1.11.61.51.51.61.71.7-1.71.6-1.7-1.91.91.8-1.41.5
Locomotion velocity, hab. session 22.02.73.71.41.4-1.41.8-1.6-1.6-1.3-1.91.7-1.31.71.71.71.71.91.8-1.71.6-1.8-1.81.81.8-1.31.4
Novel to familiar place preference ratio0.20.31.0-0.7-0.20.20.3-0.2-0.2-0.4-0.20.4-0.40.20.70.40.40.60.4-1.00.6-0.5-0.70.70.80.3-0.4
Novelty place preference0.30.40.8-0.40.2-0.20.6-0.5-0.5-0.6-0.60.6-0.70.50.90.60.60.90.6-0.90.5-0.6-0.60.60.90.2-0.3
Time in novel zone, NPP test0.30.30.7-0.30.2-0.20.6-0.5-0.5-0.6-0.60.6-0.70.50.80.60.60.80.6-0.80.5-0.6-0.60.60.8-0.0-0.1
Total zone transitions, NPP test0.60.84.0-0.5-0.70.7-0.00.10.10.50.10.00.7-0.00.2-0.00.00.20.3-1.52.0-0.4-1.91.91.0-1.21.4
Total locomotion distance, NPP test0.30.42.30.70.3-0.30.6-0.5-0.5-0.1-0.60.5-0.00.50.40.40.40.40.5-0.51.5-0.5-0.90.90.6-0.60.6
Locomotion velocity, NPP test0.20.32.20.60.2-0.20.5-0.4-0.4-0.0-0.60.40.10.40.40.30.40.40.4-0.51.5-0.4-0.80.80.6-0.40.4
Intraocular pressure0.61.05.30.10.4-0.3-0.00.10.1-0.4-0.0-0.2-0.5-0.2-0.1-0.1-0.1-0.2-0.40.8-2.00.41.7-1.7-0.92.3-2.3
Delta distance traveled before/after self-admin0.30.30.5-0.2-0.30.3-0.60.50.50.50.5-0.60.3-0.5-0.7-0.5-0.5-0.7-0.60.6-0.60.60.6-0.6-0.70.7-0.6
Delta ambulatory time before/after self-admin0.20.30.6-0.4-0.40.4-0.70.60.60.50.5-0.60.5-0.6-0.7-0.6-0.6-0.7-0.60.6-0.50.60.5-0.5-0.70.00.0
Parametrial fat weight1.63.78.42.62.9-2.82.2-2.3-2.3-2.7-2.22.1-2.72.21.72.12.11.71.60.7-0.5-1.60.6-0.60.7-0.2-0.1
Pavlov. Cond. lever latency0.10.10.50.50.3-0.30.3-0.3-0.3-0.1-0.40.2-0.20.10.10.10.10.2-0.00.1-0.70.00.6-0.6-0.20.1-0.0
Pavlov. Cond. magazine entry latency0.81.01.70.50.5-0.51.0-1.0-1.0-0.7-0.61.0-0.60.91.20.91.01.11.2-1.11.3-1.2-1.11.11.3-1.21.2
Pavlov. Cond. change in total contacts0.40.41.20.30.3-0.30.7-0.8-0.8-0.6-0.50.9-0.60.61.10.70.70.80.8-0.80.4-0.8-0.40.40.7-0.10.1
Pavlov. Cond. index score0.00.00.1-0.0-0.10.10.1-0.1-0.1-0.00.10.10.10.00.30.10.10.10.2-0.30.3-0.2-0.10.10.20.0-0.0
Pavlov. Cond. latency score0.00.10.20.00.0-0.10.2-0.2-0.2-0.2-0.00.2-0.10.20.40.20.20.30.3-0.30.5-0.3-0.30.30.4-0.10.0
Pavlov. Cond. lever contacts0.10.10.5-0.1-0.00.00.0-0.0-0.0-0.10.20.0-0.00.10.10.10.10.00.3-0.00.7-0.2-0.60.60.3-0.50.3
Pavlov. Cond. magazine entry number0.00.00.10.00.3-0.3-0.00.00.0-0.2-0.3-0.0-0.30.2-0.20.10.1-0.0-0.00.40.10.0-0.10.1-0.0-0.20.1
Pavlov. Cond. intertrial magazine entries0.20.20.70.20.0-0.0-0.20.10.1-0.10.1-0.2-0.1-0.2-0.2-0.2-0.2-0.2-0.30.6-0.80.40.7-0.7-0.50.8-0.9
Pavlov. Cond. lever-magazine prob. diff.0.00.10.3-0.1-0.20.10.2-0.2-0.2-0.10.20.20.10.10.40.10.10.20.3-0.40.5-0.3-0.40.40.4-0.10.1
Pavlov. Cond. response bias0.00.00.2-0.0-0.30.3-0.00.00.00.20.4-0.10.3-0.20.1-0.2-0.2-0.1-0.1-0.1-0.10.10.0-0.0-0.0-0.00.0
Pavlov. Cond. lever latency0.10.20.60.70.7-0.70.6-0.4-0.4-0.4-0.60.4-0.60.50.10.50.50.40.2-0.2-0.2-0.3-0.10.10.10.4-0.3
Pavlov. Cond. magazine entry latency0.81.14.3-1.7-1.31.2-0.30.40.40.60.5-0.10.9-0.30.4-0.2-0.10.10.3-2.11.8-0.3-1.81.81.3-0.80.9
Pavlov. Cond. change in total contacts0.20.61.6-0.8-0.40.40.4-0.4-0.4-0.3-0.20.6-0.00.31.00.40.40.60.8-1.21.0-0.8-1.11.11.2-1.31.0
Pavlov. Cond. index score0.30.51.6-1.3-1.00.9-0.20.20.20.40.4-0.00.7-0.20.4-0.1-0.10.00.2-1.21.3-0.3-1.11.10.9-0.90.8
Pavlov. Cond. latency score0.30.41.4-1.2-1.00.9-0.20.20.20.40.4-0.10.7-0.30.3-0.2-0.20.00.1-1.21.2-0.2-0.90.90.7-0.50.5
Pavlov. Cond. lever contacts0.10.10.5-0.7-0.60.6-0.40.20.20.20.5-0.20.5-0.40.0-0.3-0.3-0.2-0.1-0.00.20.1-0.10.10.1-0.60.4
Pavlov. Cond. magazine entry number1.11.55.22.21.8-1.70.7-0.7-0.7-1.0-0.90.3-1.30.6-0.20.50.40.1-0.12.3-1.80.11.9-1.9-1.20.8-0.9
Pavlov. Cond. intertrial magazine entries0.20.41.11.11.0-1.00.7-0.7-0.7-0.7-0.80.6-0.80.60.40.60.50.50.30.4-0.8-0.30.7-0.7-0.20.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.40.62.2-1.5-1.11.1-0.30.30.30.40.4-0.10.8-0.30.4-0.2-0.20.00.2-1.41.4-0.2-1.21.20.9-0.90.8
Pavlov. Cond. response bias0.30.51.5-1.2-0.90.8-0.30.20.20.30.4-0.00.6-0.20.3-0.1-0.1-0.00.2-1.01.0-0.3-1.01.00.8-1.21.1
Time in closed arm before self-admin0.81.42.41.31.2-1.21.6-1.5-1.5-1.0-1.51.5-1.11.21.51.31.21.51.3-0.70.0-1.3-0.20.20.9-1.11.1
Time in closed arm after self-admin0.10.10.40.60.3-0.30.3-0.3-0.3-0.2-0.30.2-0.10.30.20.30.30.30.2-0.20.0-0.20.0-0.00.10.10.0
Time in open arm before self-admin0.60.82.5-0.1-0.40.4-1.00.90.90.90.7-1.00.9-0.7-1.4-0.8-0.9-1.1-1.01.6-0.11.00.1-0.1-0.9-0.80.8
Time in open arm after self-admin0.30.30.9-0.5-0.50.5-0.70.70.70.61.0-0.60.4-0.5-0.7-0.5-0.5-0.7-0.60.5-0.20.50.1-0.1-0.40.2-0.4
Bone: periosteal estimation0.20.61.10.90.6-0.60.9-1.0-1.0-0.7-0.91.0-0.60.71.00.80.80.90.7-0.81.0-0.6-0.30.30.70.3-0.2
Bone: periosteal perimeter0.51.13.00.70.6-0.61.1-1.2-1.2-0.9-1.21.2-0.70.91.41.01.01.31.1-1.71.2-1.1-0.80.81.20.20.1
Bone: post-yield work6.010.417.21.32.0-2.13.2-3.2-3.2-2.8-3.33.5-2.63.23.93.33.43.93.6-4.13.5-3.7-3.53.54.1-2.42.4
Progressive ratio test 1 active lever presses0.20.40.80.80.5-0.50.7-0.7-0.7-0.9-0.70.7-0.70.60.70.60.60.60.5-0.60.3-0.4-0.40.40.60.7-0.7
Progressive ratio test 1 breakpoint0.20.40.70.70.5-0.50.7-0.6-0.6-0.8-0.60.7-0.70.50.70.60.60.60.4-0.60.3-0.4-0.40.40.60.8-0.8
Progressive ratio test 1 inactive lever presses0.10.20.40.30.3-0.30.4-0.4-0.4-0.5-0.50.5-0.50.40.50.40.40.50.5-0.50.2-0.5-0.10.10.4-0.60.6
Progressive ratio test 2 active lever presses1.62.33.91.91.8-1.71.9-1.9-1.9-2.0-1.71.9-1.81.61.71.61.61.61.5-0.5-0.2-1.50.1-0.11.0-0.80.7
Progressive ratio test 2 breakpoint1.62.03.51.81.7-1.71.8-1.8-1.8-1.9-1.61.8-1.71.51.61.51.51.51.4-0.5-0.3-1.40.2-0.20.9-0.70.6
Progressive ratio test 2 inactive lever presses2.06.412.23.53.3-3.23.1-3.2-3.2-3.3-3.03.0-3.02.72.62.72.62.62.40.1-0.7-2.30.7-0.71.1-1.51.4
Incentive Sensitization - Responses0.41.02.70.40.6-0.71.1-1.0-1.0-0.8-0.71.1-0.80.91.21.01.01.11.1-1.00.9-1.2-0.70.71.1-1.61.5
Incentive Sensitization - Breakpoint0.51.12.60.50.8-0.81.2-1.1-1.1-0.9-0.81.2-0.91.01.31.11.11.11.2-0.90.8-1.2-0.60.61.1-1.61.5
Sum of active levers in priming session hrs 5-63.33.16.3-1.7-1.81.9-1.61.71.71.51.8-1.61.5-1.9-1.2-1.8-1.8-1.6-1.80.4-1.91.82.0-2.0-1.72.5-2.3
Progressive ratio1.02.97.6-0.20.6-0.61.2-1.1-1.1-1.2-0.91.3-0.91.41.61.51.51.51.7-2.42.3-1.7-2.82.82.4-2.32.4
Food seeking constrained by brief footshock0.30.31.9-0.8-0.50.5-0.50.60.60.40.5-0.60.5-0.4-0.5-0.4-0.4-0.5-0.20.20.30.2-0.30.3-0.1-1.31.4
Seeking ratio, punishment vs. effort0.71.55.60.4-0.20.3-0.80.80.80.80.4-1.00.7-1.0-1.4-1.0-1.1-1.2-1.32.4-1.61.32.1-2.1-1.90.8-0.9
Retroperitoneal fat weight3.214.540.86.45.8-5.64.6-4.7-4.7-4.5-4.24.0-4.84.03.03.83.63.12.82.6-1.8-2.62.5-2.50.3-0.80.2
Reaction time number correct0.30.91.5-0.6-0.91.0-0.91.01.01.21.1-1.01.0-1.1-1.0-1.1-1.1-1.1-1.10.7-1.11.10.8-0.8-1.00.5-0.5
Reaction time mean minus median0.10.93.9-2.0-1.61.5-1.10.90.91.01.0-0.71.1-0.9-0.3-0.7-0.7-0.4-0.5-1.30.40.4-0.90.90.40.2-0.1
Reaction time mean minus median AUC0.21.33.5-1.9-1.61.6-1.41.41.41.41.4-1.21.4-1.3-0.9-1.2-1.2-0.9-1.1-0.4-0.51.0-0.10.1-0.40.7-0.6
Reaction time num false alarms0.50.92.00.1-0.50.5-0.70.90.90.90.6-1.00.8-0.9-1.3-1.0-1.0-1.1-1.11.4-0.21.20.9-0.9-1.30.9-1.0
Reaction time num false alarms AUC0.51.22.1-0.5-1.01.0-1.01.31.31.30.8-1.31.3-1.2-1.4-1.2-1.2-1.3-1.31.00.01.30.6-0.6-1.10.9-0.8
Reaction time trials correct on left0.30.91.5-0.6-0.91.0-0.91.01.01.21.1-1.01.0-1.1-1.0-1.1-1.1-1.1-1.10.7-1.11.10.8-0.8-1.00.5-0.5
Reaction time trials on left0.31.21.8-0.8-1.11.1-1.01.11.11.41.2-1.11.2-1.2-1.1-1.2-1.2-1.2-1.20.7-1.21.20.9-0.9-1.10.6-0.6
Reaction time mean0.00.10.4-0.0-0.00.0-0.0-0.2-0.2-0.1-0.00.2-0.00.10.30.20.20.20.2-0.3-0.6-0.2-0.20.20.3-0.60.6
Reaction time mean AUC0.10.10.40.10.2-0.20.2-0.4-0.4-0.3-0.20.4-0.30.30.50.30.30.50.3-0.4-0.5-0.3-0.20.20.4-0.60.6
Median of all reaction times0.20.30.70.60.6-0.60.5-0.7-0.7-0.6-0.50.6-0.50.50.60.60.60.60.6-0.2-0.5-0.5-0.10.10.4-0.90.9
Reaction time omissions0.81.33.7-1.9-1.61.6-1.51.31.31.11.3-1.11.3-1.2-0.9-1.1-1.0-0.9-0.9-0.70.20.9-0.50.5-0.11.3-1.1
Reaction time false alarm rate0.20.30.70.0-0.30.3-0.40.60.60.50.2-0.60.6-0.5-0.8-0.5-0.6-0.6-0.70.70.40.70.4-0.4-0.60.6-0.6
Reaction time premature initiation rate1.42.23.8-1.8-1.91.9-1.91.71.71.91.9-1.61.9-1.6-1.8-1.6-1.5-1.5-1.3-0.40.41.3-0.90.9-0.6-0.30.5
Reaction time premature initiations1.44.37.5-2.4-2.72.7-2.52.42.42.72.6-2.32.7-2.3-2.4-2.4-2.3-2.2-2.10.0-0.32.0-0.40.4-1.30.30.0
Std. dev. reaction times0.10.31.1-1.0-0.80.8-0.70.40.40.50.6-0.30.6-0.5-0.1-0.4-0.3-0.2-0.3-0.6-0.20.2-0.50.50.2-0.30.4
Reaction time trials completed0.31.21.8-0.8-1.11.1-1.01.11.11.41.2-1.11.2-1.2-1.1-1.2-1.2-1.2-1.20.7-1.21.20.9-0.9-1.10.6-0.6
Reaction time trials AUC0.30.91.5-0.6-0.90.9-0.91.01.01.21.1-1.01.0-1.0-1.0-1.0-1.0-1.1-1.10.7-1.11.00.8-0.8-1.00.4-0.4
Run reversals in cocaine runway, females0.60.74.8-0.3-0.10.00.00.00.0-0.00.50.00.20.30.10.30.30.00.5-0.81.3-0.5-1.21.20.8-2.12.2
Run reversals in cocaine runway, males2.12.44.1-0.8-0.91.0-1.51.41.41.31.3-1.61.2-1.5-1.7-1.6-1.6-1.7-1.61.9-1.91.62.0-2.0-2.01.2-1.3
Latency to leave start box in cocaine runway0.91.32.00.60.9-0.91.3-1.2-1.2-1.0-1.41.3-1.11.21.31.21.21.41.4-1.20.9-1.4-1.01.01.3-0.50.5
Latency to leave start box in cocaine runway, F0.60.71.10.40.7-0.71.0-0.9-0.9-0.7-1.00.9-0.80.90.90.90.91.01.0-0.80.7-1.0-0.90.91.0-0.60.6
Latency to leave start box in cocaine runway, M0.20.10.6-0.10.1-0.10.3-0.3-0.3-0.3-0.50.4-0.20.30.50.30.40.50.5-0.80.4-0.5-0.30.30.50.1-0.1
Std. dev. time between licks in bursts0.61.12.5-0.1-0.70.8-1.01.11.11.20.9-1.31.2-1.1-1.6-1.1-1.2-1.4-1.41.3-0.71.40.7-0.7-1.20.3-0.2
Total sessions with >9 infusions0.91.12.50.60.6-0.71.0-0.9-0.9-1.1-0.71.1-0.91.01.11.11.11.01.1-1.21.6-1.0-1.41.41.4-0.90.8
Short access day 1 total inactive lever presses0.61.33.21.81.6-1.61.4-1.4-1.4-1.5-1.01.2-1.51.20.91.11.10.91.00.9-0.2-0.90.3-0.30.3-1.10.7
Short access day 10 total inactive lever presses0.00.00.10.00.3-0.30.1-0.1-0.1-0.2-0.10.0-0.20.10.00.10.10.00.20.1-0.2-0.20.3-0.3-0.1-0.20.1
Short access day 1 total infusions1.22.43.91.81.8-1.81.9-1.9-1.9-2.0-1.31.9-1.81.81.61.81.71.51.6-0.40.9-1.6-0.60.61.3-0.90.7
Short access day 10 total infusions3.15.17.21.41.8-1.92.3-2.3-2.3-2.6-2.02.4-2.12.42.52.42.42.42.5-2.32.3-2.4-2.22.22.7-1.71.7
Short access total infusions1.52.23.61.21.3-1.31.5-1.5-1.5-1.9-1.11.6-1.41.61.51.61.61.41.6-1.31.6-1.5-1.51.51.7-1.01.0
Short access day 1 locomotion1.11.93.01.41.6-1.61.7-1.5-1.5-1.7-1.51.6-1.51.61.61.61.61.51.5-0.90.6-1.5-0.60.61.2-0.60.5
Short access day 10 total locomotion0.62.54.01.11.6-1.61.8-1.8-1.8-1.7-1.51.8-1.61.71.81.71.71.71.8-1.00.9-1.8-0.60.61.4-2.01.9
Short access total locomotion1.72.53.71.51.7-1.71.9-1.8-1.8-1.9-1.71.9-1.71.81.81.81.81.81.7-1.00.8-1.7-0.60.61.4-1.31.2
One hour access (0.3 mA shock)2.93.47.02.62.6-2.52.3-2.3-2.3-2.3-2.12.1-2.22.01.82.01.91.81.60.2-0.9-1.60.7-0.70.7-0.90.7
Compulsive drug intake2.63.86.4-1.8-2.22.2-2.52.42.42.32.1-2.52.3-2.1-2.5-2.2-2.2-2.3-2.11.1-0.12.00.0-0.0-1.50.6-0.5
One hour access (shock baseline)2.25.89.83.03.1-3.13.1-3.0-3.0-3.0-2.72.8-2.92.62.72.62.52.52.3-0.2-0.9-2.20.9-0.91.1-0.90.7
Social response proportion0.20.21.8-0.5-0.20.20.2-0.1-0.10.3-0.50.40.00.20.50.20.30.60.3-1.40.1-0.4-0.80.80.7-0.30.5
Social responses0.20.20.5-0.7-0.60.6-0.50.60.60.70.3-0.50.5-0.5-0.5-0.5-0.5-0.4-0.4-0.2-0.50.4-0.20.2-0.2-0.10.3
Social time0.30.51.0-1.0-0.80.8-0.90.90.91.00.8-0.80.9-0.7-0.8-0.7-0.7-0.7-0.70.2-0.30.7-0.00.0-0.4-0.00.2
Soleus weight0.82.59.93.22.4-2.31.5-1.5-1.5-1.4-1.31.0-1.71.20.41.00.90.60.52.6-1.4-0.42.1-2.1-1.00.1-0.4
Bone: stiffness0.71.25.9-0.9-0.40.30.4-0.4-0.4-0.3-0.40.7-0.00.51.10.60.70.91.0-2.42.1-1.1-1.91.91.7-0.70.9
Tibialis anterior weight6.020.840.7-6.4-6.46.3-5.55.55.55.65.6-5.15.8-5.2-4.3-5.1-4.9-4.6-4.3-0.10.84.3-0.00.0-2.22.1-1.8
Time to tail flick, vehicle, before self-admin0.20.20.9-0.10.1-0.10.3-0.3-0.3-0.3-0.20.3-0.10.40.40.40.40.40.5-0.80.9-0.6-0.80.80.7-0.40.4
Time to tail flick, vehicle, after self-admin0.51.03.70.00.2-0.20.3-0.5-0.5-0.2-0.20.5-0.30.70.60.70.80.70.7-1.11.8-0.8-1.91.91.4-1.71.6
Time to tail flick, test, before self-admin2.42.85.02.01.8-1.81.8-1.8-1.8-1.7-1.81.8-1.61.81.41.71.71.51.7-0.61.0-1.7-1.11.11.4-2.22.2
Time to tail flick, test, after self-admin0.10.11.00.3-0.00.00.1-0.2-0.2-0.20.00.1-0.1-0.00.30.10.10.20.1-0.5-0.3-0.00.3-0.30.01.0-0.9
Delta time to tail flick, vehicle, before/after SA0.40.52.7-0.2-0.10.00.1-0.2-0.20.1-0.10.3-0.10.30.40.40.40.40.4-0.80.8-0.4-1.21.20.8-1.61.6
Delta time to tail flick, test, before/after SA4.04.912.8-1.9-2.12.2-2.32.22.22.12.3-2.21.9-2.3-1.9-2.2-2.2-2.0-2.40.9-1.82.31.9-1.9-2.03.6-3.5
Tibia length0.61.73.1-1.1-1.71.7-1.31.21.21.51.2-1.11.4-1.5-0.9-1.4-1.4-1.1-1.50.4-0.91.51.0-1.0-0.91.7-1.7
Ambulatory time before self-admin0.20.61.80.20.3-0.30.7-0.8-0.8-0.6-0.60.9-0.60.71.20.80.81.10.9-1.40.8-0.9-0.90.91.1-0.30.2
Ambulatory time after self-admin0.91.42.40.91.1-1.11.4-1.5-1.5-1.2-1.31.4-1.21.21.51.31.31.41.4-1.10.3-1.4-0.40.41.1-0.70.7
Bone: tissue strength0.20.20.40.50.3-0.30.6-0.6-0.6-0.4-0.40.6-0.40.50.60.50.50.50.6-0.50.4-0.6-0.40.40.5-0.50.5
Total heroin consumption1.41.73.9-2.0-2.01.9-1.61.51.51.51.3-1.31.3-1.3-0.9-1.2-1.2-0.9-1.1-1.00.91.1-1.01.00.01.2-1.0
Bone: trabecular number1.42.66.3-0.00.5-0.61.2-1.3-1.3-1.2-0.91.5-1.01.41.81.51.51.61.7-2.52.4-1.7-2.52.52.4-1.21.2
Bone: trabecular spacing0.20.31.40.30.0-0.0-0.40.40.40.40.4-0.60.3-0.4-0.8-0.4-0.5-0.7-0.61.2-1.00.60.8-0.8-0.9-0.40.4
Bone: trabecular thickness1.62.23.21.31.4-1.41.6-1.7-1.7-1.6-1.51.7-1.51.61.81.71.71.71.6-1.00.8-1.6-1.21.21.6-1.00.8
Bone: trabecular tissue density0.91.65.92.11.4-1.30.8-0.9-0.9-0.8-0.80.6-0.90.50.30.40.30.2-0.01.9-1.70.12.4-2.4-1.11.7-1.8
Water consumed over 24 hours0.20.30.7-0.8-0.80.8-0.60.50.50.70.4-0.40.7-0.5-0.4-0.5-0.4-0.3-0.3-0.40.40.3-0.60.60.2-0.80.8
Number of responses in last shaping day0.10.20.4-0.2-0.20.2-0.60.50.50.10.5-0.60.3-0.4-0.6-0.4-0.4-0.6-0.30.3-0.10.30.1-0.1-0.40.5-0.5