Hub : Genes

Usp16

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Usp16 0.19 0.1 7.2e-04 0.13 0.11 0.11 0.14 4.4e-04 1.5e-03 1.5e-03 4.0e-04
2 NAcc gene expression Usp16 0.08 0.04 1.6e-08 0.05 0.06 0.05 0.05 2.0e-06 4.7e-08 2.0e-06 6.1e-07
3 Brain intron excision ratio chr11_26697570_26700254 0.04 0.02 2.5e-03 0.02 0.02 0.02 0.02 3.9e-03 3.2e-03 7.9e-03 4.2e-03
4 Brain isoform ratio NM_001100501.1 0.05 0.03 1.1e-03 0.04 0.03 0.03 0.04 1.3e-04 2.1e-03 6.5e-04 1.2e-04
5 Adipose gene expression Usp16 0.42 0.11 0.0e+00 0.31 0.32 0.32 0.32 1.6e-34 2.5e-36 1.2e-36 7.9e-37
6 LHb gene expression Usp16 0.44 0.14 6.7e-07 0.18 0.19 0.21 0.23 5.2e-05 2.4e-05 1.0e-05 4.3e-06
7 Brain isoform ratio XM_039088222.1 0.04 0.02 4.3e-03 0.02 0.01 0.01 0.02 7.0e-03 4.6e-02 2.4e-02 6.1e-03
8 Adipose mRNA stability Usp16 0.21 0.09 0.0e+00 0.14 0.14 0.14 0.14 2.4e-15 1.1e-15 4.3e-15 4.8e-15
9 Brain gene expression Usp16 0.67 0.11 5.4e-14 0.09 0.12 0.14 0.15 5.1e-09 2.9e-11 1.6e-12 3.6e-14
10 OFC gene expression Usp16 0.24 0.15 3.1e-03 0.06 0.09 0.1 0.15 1.5e-02 3.8e-03 2.2e-03 2.3e-04
11 PL gene expression Usp16 0.25 0.11 4.2e-11 0.1 0.1 0.11 0.11 9.4e-11 7.9e-11 6.8e-12 4.0e-12
12 Liver gene expression Usp16 0.09 0.04 3.4e-06 0.01 0.03 0.04 0.03 1.1e-02 1.1e-04 6.4e-05 1.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.42.43.71.31.4-1.31.01.91.8-1.11.71.81.71.8-1.6
Area under the delay curve1.21.32.70.61.2-1.00.61.51.6-1.01.20.91.31.4-0.0
BMI with tail0.62.08.60.10.6-0.30.11.01.2-0.11.22.91.61.2-2.6
BMI without tail2.04.17.51.71.9-2.21.42.02.1-1.42.72.52.21.9-1.9
Body weight0.20.82.70.50.8-0.50.80.40.7-0.70.51.61.01.0-1.3
Weight adjusted by age2.42.74.7-2.0-2.22.1-1.9-1.7-1.21.9-1.7-0.8-1.2-1.61.0
Bone surface1.42.55.92.01.2-1.41.31.41.2-1.01.82.11.41.1-2.4
Bone volume2.23.76.72.01.5-1.71.42.01.9-1.22.32.42.01.7-2.6
Breakpoint value in progressive ratio session1.11.32.7-0.4-0.90.7-0.3-1.5-1.60.7-1.1-1.2-1.5-1.60.9
Number of licking bursts0.10.10.40.1-0.1-0.3-0.30.2-0.20.40.5-0.3-0.4-0.4-0.6
Context. condit. distance diff. score2.12.55.32.31.8-2.12.10.91.3-2.21.30.71.31.60.1
Locomotion velocity, session 11.11.22.90.71.2-0.60.91.11.2-1.10.71.31.41.7-0.7
Locomotion distance, session 10.30.41.00.60.8-0.40.80.50.5-0.70.40.90.71.0-0.3
Locomotion velocity, session 20.30.41.20.3-0.20.30.6-0.7-1.1-0.1-0.7-0.4-1.0-0.7-0.6
Locomotion distance, session 20.10.10.40.40.2-0.20.6-0.1-0.5-0.30.0-0.2-0.4-0.3-0.2
Locomotion velocity, session 33.44.010.41.01.9-0.91.51.81.9-1.71.23.22.22.7-2.4
Locomotion distance, session 32.42.65.60.71.9-1.01.51.71.7-1.80.92.01.72.4-1.1
Stereotopy head waving bouts, day 30.81.02.6-1.6-1.11.4-1.6-0.4-0.51.4-0.80.2-0.4-0.3-0.0
Stereotopy head waving duration, day 30.40.51.1-1.0-0.81.1-1.0-0.7-0.60.9-0.80.2-0.5-0.2-0.0
Locomotion velocity, session 70.30.31.1-0.20.60.10.10.70.8-0.5-0.10.50.71.10.2
Locomotion distance, session 71.11.42.71.11.6-1.11.31.21.2-1.60.3-0.11.01.51.0
Stereotopy head waving bouts, day 70.50.63.3-0.3-0.0-0.0-0.50.80.20.50.91.20.40.5-1.8
Stereotopy head waving duration, day 70.91.16.0-0.8-0.70.7-1.10.3-0.31.20.61.60.1-0.0-2.5
Locomotion velocity, session 82.42.85.51.71.6-1.61.71.11.4-1.61.62.31.71.7-1.8
Locomotion distance, session 80.91.43.51.91.3-1.81.60.70.6-1.41.30.30.60.8-0.2
Degree of sensitization distance0.50.51.90.5-0.30.00.1-0.7-0.60.1-0.6-1.4-0.8-0.91.2
Degree of sensitization stereotypy0.70.85.4-0.0-0.0-0.2-0.30.60.10.41.01.50.50.3-2.3
Conditioned locomotion0.10.10.4-0.4-0.10.0-0.70.5-0.20.50.3-0.5-0.3-0.20.1
Cocaine response after cond. corrected2.32.53.81.91.9-1.81.91.91.2-1.71.71.11.01.3-1.5
Cocaine response after cond. not corrected1.71.83.41.81.6-1.71.71.40.8-1.51.50.90.81.0-1.1
Cocaine response before conditioning1.01.23.3-0.7-1.30.8-0.9-1.8-1.21.0-1.0-0.8-0.9-1.31.1
Saline control response0.81.03.0-0.8-1.21.1-0.7-1.7-1.10.8-1.2-0.3-0.9-1.00.4
Bone: connectivity density1.32.12.91.41.5-1.11.31.71.5-1.31.31.61.41.6-1.3
Bone: cortical apparent density0.30.41.1-0.7-0.70.4-1.0-0.3-0.20.7-0.3-0.9-0.3-0.41.1
Bone: cortical area0.20.32.10.60.0-0.20.30.2-0.20.10.51.00.0-0.1-1.4
Bone: cortical porosity0.30.41.10.90.6-1.10.70.60.3-0.51.0-0.30.20.10.0
Bone: cortical porosity0.40.41.31.00.5-1.20.60.60.4-0.41.1-0.40.3-0.10.0
Bone: cortical thickness0.91.52.1-1.2-1.31.3-1.3-1.2-1.41.3-1.2-0.9-1.4-1.30.6
Bone: cortical thickness0.10.10.40.4-0.4-0.5-0.2-0.3-0.10.30.6-0.2-0.2-0.6-0.3
Bone: cortical tissue density0.30.31.2-0.6-0.60.3-0.9-0.2-0.10.6-0.2-1.0-0.2-0.31.1
Condit. Reinf. active minus inactive responses2.02.33.8-1.8-1.92.0-1.8-1.5-1.71.8-1.40.1-1.3-1.2-0.1
Condit. Reinf. active-inactive response ratio3.03.25.5-2.2-2.22.3-2.2-1.9-1.82.2-1.70.2-1.4-1.5-0.3
Condit. Reinf. active responses0.40.51.0-0.7-0.91.0-0.8-0.7-0.80.7-0.70.2-0.6-0.4-0.1
Condit. Reinf. inactive responses1.11.32.31.51.3-1.31.51.01.0-1.50.90.00.91.20.3
Incentive salience index mean2.02.44.4-1.7-1.82.1-1.5-1.8-1.81.6-1.70.3-1.3-1.2-0.4
Condit. Reinf. lever presses1.92.64.9-1.6-1.72.2-1.2-1.9-2.01.5-2.1-0.1-1.5-1.4-0.2
Condit. Reinf. active minus inactive responses1.21.53.4-1.8-1.61.5-1.8-1.0-0.91.6-0.9-0.0-0.6-0.80.3
Condit. Reinf. active-inactive response ratio0.00.00.2-0.3-0.20.1-0.40.1-0.00.30.10.20.10.00.1
Condit. Reinf. active responses1.82.54.7-2.2-2.12.1-2.1-1.6-1.22.0-1.30.8-0.6-1.1-0.4
Condit. Reinf. inactive responses1.11.32.4-1.2-1.41.5-1.1-1.5-0.81.3-0.91.1-0.4-0.9-1.0
Condit. Reinf. lever presses0.30.41.2-1.0-0.90.8-1.1-0.6-0.20.9-0.40.00.0-0.40.1
Condit. Reinf. lever reinforcers received1.52.14.4-2.1-1.91.9-2.1-1.4-0.81.9-1.01.1-0.3-0.8-0.7
Conditioned reinforcement - actives1.21.21.91.11.2-1.11.11.11.3-1.20.90.61.31.4-0.3
Conditioned reinforcement - inactives0.10.10.8-0.10.0-0.1-0.00.10.1-0.2-0.1-0.9-0.10.10.6
Conditioned locomotion1.72.03.61.81.7-1.81.91.21.3-1.81.20.71.31.2-0.5
Patch foraging indifference point 0 sec1.82.94.7-1.5-1.91.2-1.7-2.2-1.41.6-1.4-2.1-1.6-2.01.9
Patch foraging indifference point AUC0.30.31.30.30.7-0.00.50.50.4-0.5-0.21.10.60.7-0.5
Delay disc. indifference point, 0s delay0.40.52.3-0.40.20.0-0.10.50.50.10.51.50.70.5-1.3
Delay disc. indifference point, 16s delay0.50.50.80.90.8-0.70.80.70.8-0.80.60.10.50.60.3
Delay disc. indifference point, 2s delay0.10.10.2-0.20.2-0.2-0.20.30.4-0.10.20.00.20.30.4
Delay disc. indifference point, 24s delay2.72.74.41.91.9-1.91.91.52.0-2.11.30.31.51.60.4
Delay disc. indifference point, 4s delay0.10.10.3-0.50.1-0.1-0.30.40.50.10.30.40.30.4-0.3
Delay disc. indifference point, 8s delay1.01.02.40.31.0-0.80.21.51.6-0.81.00.61.31.50.4
Indifference point function ln k1.42.04.3-0.5-1.70.5-1.1-1.8-1.41.3-0.4-2.0-1.6-2.11.2
Indifference point function log k1.42.04.3-0.5-1.70.5-1.1-1.8-1.41.3-0.4-2.0-1.6-2.11.2
Patch foraging total patch changes 0 sec1.83.04.9-1.5-1.91.2-1.7-2.2-1.41.6-1.4-2.0-1.6-2.01.8
Patch foraging total patch changes 12 sec1.01.33.6-1.0-1.01.4-0.8-1.6-1.20.8-1.9-0.4-1.0-1.00.8
Patch foraging total patch changes 18 sec0.20.20.50.70.3-0.70.4-0.20.5-0.40.40.20.5-0.10.4
Patch foraging total patch changes 24 sec1.41.73.4-1.3-1.71.3-1.5-1.8-1.11.4-1.1-0.7-0.9-1.31.0
Patch foraging total patch changes 6 sec0.60.91.5-0.7-0.80.6-0.8-1.2-0.90.8-1.0-1.1-0.9-1.21.0
Patch foraging time to switch 0 sec0.30.41.30.40.7-0.30.61.10.5-0.40.50.50.40.5-1.0
Patch foraging water rate 0 sec0.10.20.50.40.3-0.60.2-0.20.5-0.30.50.70.60.5-0.1
Patch foraging water rate 12 sec0.40.61.8-0.1-0.90.1-0.3-1.3-1.00.6-0.1-0.5-1.0-1.20.1
Patch foraging water rate 18 sec0.10.10.7-0.0-0.2-0.4-0.2-0.40.00.30.70.20.1-0.1-0.8
Patch foraging water rate 24 sec0.10.10.40.40.2-0.60.3-0.5-0.0-0.30.2-0.6-0.1-0.20.5
Patch foraging water rate 6 sec0.71.02.0-0.7-1.30.8-1.0-1.3-1.21.2-0.4-0.6-1.1-1.40.1
Seeking ratio, delayed vs. immediate footshock0.50.60.70.80.7-0.50.80.70.8-0.80.60.80.80.8-0.7
Distance traveled before self-admin0.60.61.51.00.8-1.01.00.40.2-1.00.3-0.90.00.21.2
Distance traveled after self-admin1.01.14.00.30.8-0.40.41.31.1-0.51.02.01.31.2-1.0
Extensor digitorum longus weight2.710.817.22.83.1-2.82.83.13.7-2.83.24.13.93.3-3.2
Bone: elastic displacement0.50.61.10.40.8-0.50.51.01.0-0.60.71.01.01.0-0.4
Bone: elastic work0.81.02.90.30.5-0.50.11.11.2-0.21.11.71.20.8-1.4
Bone: endosteal estimation2.24.99.82.41.6-1.81.71.72.1-1.42.53.12.51.8-3.1
Bone: endosteal perimeter1.12.37.21.61.0-1.01.31.11.1-0.91.52.41.30.9-2.7
Epididymis fat weight0.92.14.20.41.5-1.20.61.81.9-1.01.51.62.02.0-0.5
Delta time in closed arm before/after self-admin1.01.01.8-1.2-1.11.2-1.2-1.0-0.71.3-0.51.3-0.2-0.5-1.0
Delta time in open arm before/after self-admin0.40.41.40.1-0.2-0.10.1-0.7-0.50.1-0.4-1.1-0.7-0.81.2
Diff in mean of infusions in LGA sessions0.10.10.40.60.1-0.20.6-0.4-0.5-0.3-0.1-0.1-0.3-0.40.2
Delay discount exponential model param1.01.12.4-0.6-1.11.0-0.6-1.4-1.50.9-1.1-0.7-1.2-1.3-0.2
Extinction: sum of active levers before priming4.14.15.6-2.3-2.32.2-2.2-2.2-2.22.4-1.8-0.9-1.9-2.20.8
Active lever presses in extinction session 60.90.82.4-0.2-0.40.2-0.1-1.0-1.00.3-0.8-1.5-1.2-1.21.4
Bone: final force0.40.72.40.3-0.4-0.3-0.50.40.50.61.31.40.70.0-1.6
Bone: final moment0.30.61.80.4-0.3-0.5-0.40.40.50.51.41.20.7-0.0-1.3
Food consumed during 24 hour testing period0.81.02.0-0.5-1.00.9-0.4-1.3-1.40.7-1.1-0.6-1.4-1.30.7
Glucose0.30.41.6-0.00.6-0.10.30.60.5-0.50.21.20.60.9-0.8
Heart weight1.11.63.41.41.5-1.61.91.11.0-1.71.20.60.90.9-0.6
Delay discount hyperbolic model param0.80.92.0-0.4-1.00.9-0.4-1.3-1.40.8-1.0-0.6-1.1-1.2-0.2
Intermittent access intake day 1-15 change0.60.61.20.20.7-0.50.31.10.9-0.50.91.11.00.9-0.4
Intermittent access intake escalation0.40.41.00.10.7-0.50.31.00.8-0.40.80.70.90.9-0.1
Intermittent access intake escalation 20.00.00.1-0.3-0.10.2-0.30.20.00.30.0-0.10.1-0.00.2
Intermitt. access day 1 inactive lever presses0.50.51.2-0.3-0.80.6-0.4-0.8-1.00.6-0.6-0.7-1.0-1.10.1
Intermitt. access day 15 inactive lever presses0.10.10.30.50.2-0.20.60.10.2-0.50.1-0.00.10.0-0.5
Intermitt. access escalation Index0.50.42.8-0.5-0.40.3-0.6-0.1-0.30.2-0.5-0.9-0.3-0.11.7
Intermittent access day 1 total infusions1.21.43.41.81.5-1.61.80.90.8-1.70.9-0.20.60.7-0.4
Intermittent access day 15 total infusions1.72.02.91.51.7-1.61.61.71.4-1.71.30.61.21.3-0.3
Intermittent access terminal intake (last 3 days)0.20.20.50.60.6-0.60.70.40.3-0.60.4-0.10.20.1-0.2
Intermittent access total infusions0.50.51.11.00.9-1.01.10.70.5-0.90.70.10.40.3-0.4
Intermittent access day 1 locomotion6.36.712.53.33.2-3.33.52.12.2-3.32.21.12.02.1-0.9
Intermittent access day 15 total locomotion2.42.64.02.01.9-1.91.91.71.4-1.71.61.21.41.4-1.0
Intermittent access total locomotion6.37.210.73.13.2-3.23.32.72.5-3.02.61.82.42.3-1.4
Intermittent access standard deviation0.10.10.2-0.5-0.10.2-0.40.30.20.30.1-0.00.1-0.10.1
Left kidney weight0.61.84.1-1.3-1.20.8-1.1-1.0-1.10.9-1.0-2.0-1.5-1.32.0
Right kidney weight0.20.41.4-0.9-0.50.5-0.5-0.2-0.40.3-0.4-1.1-0.6-0.41.2
Cocaine induced anxiety0.91.01.41.11.2-1.11.11.21.2-1.20.90.51.11.0-0.1
Post-drug Anxiety1.61.72.81.21.3-1.11.11.61.7-1.31.21.11.61.6-0.8
Baseline Anxiety0.70.82.0-1.4-1.11.2-1.4-0.4-0.51.2-0.6-0.2-0.4-0.4-0.0
Tail length0.20.51.21.10.6-1.11.00.20.1-0.80.6-0.9-0.20.00.8
Length with tail0.20.83.00.30.3-0.11.0-0.8-0.6-0.8-1.0-1.6-0.8-0.31.7
Length without tail1.12.45.1-1.9-1.52.1-1.2-1.5-1.51.1-2.3-1.2-1.4-1.11.2
Times rat made contact with spout4.55.27.8-2.0-2.42.4-1.8-2.8-2.52.1-2.6-1.7-2.6-2.61.5
Lifetime Intake0.40.40.80.80.8-0.90.90.60.4-0.80.6-0.00.20.3-0.5
Liver weight, left2.23.46.62.02.0-2.61.72.02.1-1.92.40.71.81.6-0.3
Liver weight, right0.20.31.30.10.3-0.60.10.50.10.01.00.70.20.0-1.1
Locomotor activity0.20.31.9-0.20.2-0.3-0.00.20.9-0.30.1-0.70.70.21.4
Locomotor testing distance0.81.32.61.01.3-1.11.20.91.6-1.50.4-0.21.41.01.2
Locomotor testing rearing0.30.41.20.30.6-0.40.50.21.1-0.7-0.00.10.90.51.1
Locomotion in novel chamber1.01.34.60.40.6-0.20.41.21.3-0.50.92.21.61.2-1.5
Locomotion in novel chamber post-restriction2.42.84.31.91.9-1.72.11.81.6-1.91.51.11.51.5-1.4
Fecal boli incidents, locomotor time 10.20.20.6-0.8-0.40.4-0.6-0.6-0.60.6-0.3-0.1-0.3-0.4-0.2
Change in fecal boli incidents, locomotor task0.10.10.20.2-0.10.10.4-0.50.1-0.3-0.30.10.1-0.00.1
Time >=10cm from walls, locomotor time 10.60.61.30.30.8-0.70.51.11.1-0.80.80.21.01.1-0.1
Bouts of movement, locomotor time 13.74.15.2-2.3-2.21.9-2.2-1.9-2.12.1-1.8-1.9-2.2-2.01.6
Total resting periods, locomotor time 14.95.47.2-2.7-2.52.3-2.6-2.3-2.42.4-2.0-2.1-2.5-2.31.7
Rest time, locomotor task time 11.11.33.0-1.7-1.00.9-1.5-0.9-0.81.2-0.8-1.1-0.9-0.91.2
Distance moved, locomotor task time 10.20.20.70.80.2-0.10.50.30.3-0.30.20.60.50.3-0.6
Vertical activity count, locomotor time 10.70.72.41.60.9-0.81.30.90.5-1.00.5-0.10.50.5-0.2
Time >=10cm from walls, locomotor time 20.20.20.80.40.1-0.40.5-0.4-0.3-0.3-0.1-0.9-0.5-0.40.3
Bouts of movement, locomotor time 21.01.12.8-1.1-1.00.9-1.1-0.7-1.00.9-0.9-1.3-0.9-0.71.7
Total resting periods, locomotor time 22.12.23.9-1.8-1.51.4-1.6-1.0-1.51.4-1.3-1.7-1.4-1.12.0
Rest time, locomotor task time 22.73.15.5-2.3-2.01.9-2.1-1.8-1.72.2-1.5-0.7-1.6-1.80.3
Distance moved, locomotor task time 21.31.53.71.91.4-1.51.61.11.0-1.31.00.71.10.9-0.6
Vertical activity count, locomotor time 25.05.511.73.42.9-2.93.02.32.0-2.82.00.31.71.8-0.2
Light reinforcement 10.61.12.21.21.0-0.91.30.31.5-1.40.40.41.41.10.9
Light reinforcement 20.91.32.51.01.1-0.91.00.81.4-1.10.81.21.61.5-0.4
Bone: marrow area2.35.110.02.51.7-1.91.81.72.1-1.42.53.12.51.8-3.2
Bone: maximum diameter1.12.05.11.71.2-1.21.31.30.8-1.01.52.01.11.0-2.2
Bone: maximum force0.30.51.90.5-0.2-0.4-0.30.40.50.51.31.20.7-0.0-1.4
Bone: maximum moment0.30.51.70.6-0.2-0.6-0.20.40.50.41.30.90.6-0.1-1.1
Mean time between licks in bursts0.81.12.3-0.8-1.51.1-1.3-1.3-0.91.5-0.6-0.1-0.8-1.2-0.1
Mean num. licks in bursts1.31.63.9-1.1-1.21.5-0.6-1.8-1.10.6-2.0-0.7-1.1-1.01.5
Cd content in liver0.50.62.6-0.3-0.40.5-0.1-0.9-0.6-0.0-1.0-1.0-0.6-0.11.6
Co content in liver1.41.64.5-1.9-1.41.3-2.1-0.5-0.61.8-0.7-0.9-0.8-0.81.0
Cu content in liver0.81.01.70.91.3-1.11.21.01.1-1.30.70.41.01.1-0.1
Fe content in liver0.10.20.80.50.0-0.40.3-0.2-0.30.00.40.3-0.2-0.5-0.9
K content in liver0.20.20.8-0.5-0.30.7-0.3-0.6-0.70.3-0.90.2-0.5-0.2-0.2
Mg content in liver1.21.23.1-0.9-1.01.4-0.5-1.6-1.50.7-1.7-0.3-1.2-1.00.1
Mn content in liver1.21.43.5-1.4-1.01.7-0.8-1.4-1.40.8-1.9-0.1-1.1-0.7-0.2
Na content in liver0.10.10.7-0.4-0.10.3-0.10.1-0.40.2-0.20.1-0.3-0.1-0.8
Rb content in liver1.01.22.8-0.7-1.60.5-1.4-1.0-1.11.6-0.0-0.7-1.1-1.7-0.3
Se content in liver0.81.02.6-0.5-0.40.8-0.0-1.4-1.30.1-1.6-1.2-1.2-0.61.4
Sr content in liver0.70.74.8-0.30.20.20.2-0.60.0-0.5-0.8-1.3-0.20.22.2
Zn content in liver0.60.71.91.30.9-1.21.4-0.10.4-1.20.3-0.70.30.10.8
Bone: minimum diameter0.81.46.91.30.6-0.50.90.60.4-0.41.02.20.70.5-2.6
Time in familiar zone, hab. session 10.10.10.30.20.2-0.40.30.30.1-0.20.3-0.5-0.2-0.20.2
Time in novel zone, hab. session 10.10.10.40.4-0.2-0.3-0.0-0.6-0.20.10.10.00.0-0.30.1
Total zone transitions, hab. session 10.20.30.8-0.5-0.50.4-0.4-0.4-0.60.4-0.4-0.7-0.7-0.60.9
Total locomotion distance, hab. session 10.10.10.3-0.3-0.2-0.0-0.1-0.2-0.30.1-0.0-0.6-0.4-0.50.6
Locomotion velocity, hab. session 10.00.10.2-0.20.1-0.10.10.1-0.2-0.10.0-0.4-0.3-0.30.5
Time in familiar zone, hab. session 20.50.51.3-0.1-0.7-0.0-0.4-0.7-1.00.70.1-0.8-1.0-1.2-0.2
Time in novel zone, hab. session 20.00.00.1-0.1-0.10.1-0.3-0.00.30.10.00.40.30.20.3
Total zone transitions, hab. session 21.11.42.1-1.3-1.31.4-1.0-1.4-1.51.2-1.3-0.4-1.2-1.30.0
Total locomotion distance, hab. session 20.71.01.8-0.9-0.70.9-0.3-1.2-1.30.5-1.3-1.0-1.3-1.10.6
Locomotion velocity, hab. session 20.40.51.4-0.7-0.20.60.1-0.9-1.00.1-1.2-0.8-0.9-0.70.5
Novel to familiar place preference ratio0.10.10.7-0.1-0.20.3-0.00.00.20.10.00.70.20.1-0.8
Novelty place preference0.10.10.90.0-0.20.1-0.0-0.10.10.20.10.70.2-0.1-0.9
Time in novel zone, NPP test0.20.21.2-0.0-0.40.1-0.2-0.10.10.30.30.80.2-0.2-1.1
Total zone transitions, NPP test0.10.20.5-0.1-0.30.4-0.0-0.7-0.70.2-0.50.3-0.4-0.3-0.5
Total locomotion distance, NPP test0.10.20.50.50.2-0.20.7-0.5-0.7-0.4-0.2-0.3-0.6-0.3-0.1
Locomotion velocity, NPP test0.20.31.20.70.5-0.41.1-0.3-0.5-0.8-0.2-0.2-0.4-0.1-0.0
Intraocular pressure0.81.24.70.6-0.0-1.1-0.40.91.00.32.21.51.10.4-1.5
Delta distance traveled before/after self-admin1.92.07.50.30.8-0.30.51.51.4-0.61.22.71.71.5-2.1
Delta ambulatory time before/after self-admin1.31.46.20.30.6-0.20.41.01.0-0.40.92.51.31.1-2.0
Parametrial fat weight0.10.20.7-0.7-0.40.1-0.80.0-0.00.80.40.20.1-0.2-0.0
Pavlov. Cond. lever latency0.50.71.90.70.6-1.10.20.91.2-0.41.40.10.90.70.0
Pavlov. Cond. magazine entry latency2.63.35.4-1.9-1.92.3-1.5-2.0-2.21.7-2.3-0.9-2.0-1.80.4
Pavlov. Cond. change in total contacts0.60.71.9-0.4-0.61.1-0.0-1.0-1.30.3-1.4-0.4-1.1-0.80.1
Pavlov. Cond. index score1.31.63.2-1.1-1.21.6-0.6-1.5-1.80.9-1.8-0.5-1.5-1.3-0.1
Pavlov. Cond. latency score1.31.73.3-1.1-1.21.6-0.7-1.5-1.81.0-1.8-0.6-1.6-1.40.1
Pavlov. Cond. lever contacts1.31.53.1-1.2-1.21.6-0.7-1.4-1.70.9-1.8-0.6-1.4-1.20.1
Pavlov. Cond. magazine entry number1.51.93.61.31.3-1.80.81.61.8-1.01.90.71.61.4-0.2
Pavlov. Cond. intertrial magazine entries1.51.83.70.61.2-0.70.81.71.6-1.01.11.71.81.9-0.9
Pavlov. Cond. lever-magazine prob. diff.1.51.83.5-1.3-1.31.8-0.7-1.6-1.91.0-1.8-0.3-1.5-1.4-0.2
Pavlov. Cond. response bias2.63.16.4-1.9-1.72.5-1.3-1.9-2.21.4-2.5-0.6-1.8-1.50.2
Pavlov. Cond. lever latency0.30.41.00.70.9-0.51.00.70.0-0.80.20.1-0.10.5-0.3
Pavlov. Cond. magazine entry latency0.00.00.10.20.0-0.10.1-0.3-0.0-0.1-0.20.10.10.0-0.1
Pavlov. Cond. change in total contacts1.01.44.1-1.5-1.71.3-2.0-1.3-0.61.7-0.60.1-0.3-0.90.1
Pavlov. Cond. index score0.50.61.4-0.7-1.10.7-1.2-1.1-0.51.1-0.4-0.1-0.3-0.80.1
Pavlov. Cond. latency score0.50.61.3-0.7-1.10.7-1.1-1.1-0.61.0-0.5-0.1-0.4-0.80.1
Pavlov. Cond. lever contacts0.20.20.7-0.4-0.70.2-0.6-0.8-0.10.6-0.1-0.5-0.1-0.70.4
Pavlov. Cond. magazine entry number0.30.40.80.50.8-0.70.80.90.5-0.80.5-0.20.20.50.4
Pavlov. Cond. intertrial magazine entries0.30.41.4-0.7-0.60.6-0.6-0.2-0.10.80.10.90.0-0.4-1.2
Pavlov. Cond. lever-magazine prob. diff.0.40.51.2-0.6-1.00.6-1.1-1.0-0.41.0-0.3-0.1-0.2-0.70.2
Pavlov. Cond. response bias0.20.20.6-0.4-0.70.3-0.7-0.8-0.20.6-0.3-0.3-0.1-0.50.2
Time in closed arm before self-admin4.45.06.82.32.6-2.52.22.62.4-2.52.11.12.22.6-0.9
Time in closed arm after self-admin0.50.51.4-0.30.20.1-0.40.70.7-0.00.51.20.91.1-0.8
Time in open arm before self-admin3.94.27.4-2.6-2.62.7-2.6-2.0-1.82.7-1.8-0.1-1.5-1.80.2
Time in open arm after self-admin0.50.51.1-0.7-0.70.7-0.7-0.9-0.40.7-0.7-0.4-0.4-0.81.0
Bone: periosteal estimation1.42.87.62.01.2-1.31.41.21.2-1.01.82.41.61.2-2.8
Bone: periosteal perimeter0.71.15.21.20.6-0.50.90.50.4-0.40.91.90.70.3-2.3
Bone: post-yield work0.00.00.10.3-0.10.0-0.1-0.1-0.10.20.1-0.2-0.0-0.1-0.1
Progressive ratio test 1 active lever presses1.21.21.91.11.4-1.41.31.01.0-1.31.10.60.91.0-0.9
Progressive ratio test 1 breakpoint0.70.71.21.01.0-1.11.10.60.6-1.00.80.40.50.6-0.8
Progressive ratio test 1 inactive lever presses1.41.52.11.01.3-1.21.21.11.3-1.31.11.01.21.3-1.4
Progressive ratio test 2 active lever presses1.41.51.81.21.3-1.21.21.31.3-1.21.21.21.31.2-1.1
Progressive ratio test 2 breakpoint1.11.31.51.11.2-1.11.11.21.2-1.01.11.21.21.0-1.1
Progressive ratio test 2 inactive lever presses1.82.13.11.61.7-1.71.81.51.5-1.81.30.51.31.3-0.5
Incentive Sensitization - Responses0.10.10.3-0.3-0.40.4-0.4-0.3-0.20.5-0.10.3-0.1-0.4-0.2
Incentive Sensitization - Breakpoint0.10.10.2-0.2-0.30.3-0.4-0.2-0.10.5-0.10.3-0.1-0.3-0.1
Sum of active levers in priming session hrs 5-61.41.33.6-0.9-1.00.7-0.7-1.7-1.31.2-1.0-0.9-1.3-1.90.6
Progressive ratio1.21.32.5-1.4-1.61.5-1.6-1.0-1.01.5-1.0-0.5-0.9-0.8-0.3
Food seeking constrained by brief footshock0.30.31.70.3-0.1-0.20.0-0.4-0.40.0-0.2-1.3-0.7-0.60.8
Seeking ratio, punishment vs. effort0.50.61.30.91.0-1.20.90.70.5-0.90.7-0.60.30.31.1
Retroperitoneal fat weight1.13.55.31.72.3-1.91.92.02.1-2.01.71.62.22.1-0.6
Reaction time number correct1.62.36.12.51.5-2.42.20.80.8-1.82.0-0.40.50.4-0.3
Reaction time mean minus median0.10.10.3-0.30.2-0.1-0.20.30.4-0.00.1-0.30.40.30.6
Reaction time mean minus median AUC0.10.20.30.20.5-0.60.30.50.5-0.40.4-0.20.50.30.3
Reaction time num false alarms0.30.41.30.40.6-0.8-0.01.10.8-0.31.00.00.60.60.3
Reaction time num false alarms AUC0.40.61.50.70.8-1.00.21.20.9-0.51.0-0.00.70.70.5
Reaction time trials correct on left1.62.36.12.51.5-2.42.20.80.8-1.82.0-0.40.50.4-0.3
Reaction time trials on left1.82.66.52.51.6-2.62.20.90.9-1.92.1-0.40.60.5-0.3
Reaction time mean0.71.02.6-0.10.6-0.1-0.11.21.4-0.20.51.51.61.4-1.0
Reaction time mean AUC0.91.23.20.20.8-0.40.11.31.6-0.40.81.51.81.5-0.9
Median of all reaction times0.81.12.80.10.7-0.10.11.21.3-0.30.51.71.61.4-1.4
Reaction time omissions1.41.93.21.21.6-1.71.11.51.8-1.41.50.31.61.40.0
Reaction time false alarm rate0.20.31.2-0.9-0.30.5-1.10.50.20.7-0.20.20.20.30.5
Reaction time premature initiation rate0.40.51.30.30.7-0.40.51.11.0-0.70.60.40.91.0-0.0
Reaction time premature initiations1.42.03.21.71.6-1.81.71.51.4-1.71.60.21.21.2-0.3
Std. dev. reaction times0.20.31.1-0.40.40.0-0.20.71.0-0.10.10.51.10.90.0
Reaction time trials completed1.82.66.52.51.6-2.62.20.90.9-1.92.1-0.40.60.5-0.3
Reaction time trials AUC1.82.56.32.51.6-2.52.11.01.0-1.82.1-0.30.70.5-0.5
Run reversals in cocaine runway, females2.12.03.31.11.7-1.51.31.51.8-1.61.30.61.51.7-0.4
Run reversals in cocaine runway, males0.60.61.2-0.3-0.70.6-0.4-0.8-1.10.7-0.7-0.9-1.0-1.10.5
Latency to leave start box in cocaine runway0.20.21.0-0.2-0.20.2-0.1-0.5-0.40.2-0.5-0.6-0.4-0.41.0
Latency to leave start box in cocaine runway, F0.20.21.20.10.1-0.20.2-0.4-0.2-0.2-0.3-0.7-0.2-0.31.1
Latency to leave start box in cocaine runway, M0.10.10.4-0.2-0.00.2-0.30.20.10.20.00.50.30.2-0.6
Std. dev. time between licks in bursts1.51.83.3-1.8-1.61.5-1.7-1.2-1.31.8-0.9-0.2-1.2-1.4-0.6
Total sessions with >9 infusions1.71.83.81.81.6-1.71.91.30.9-1.81.1-0.20.71.1-0.5
Short access day 1 total inactive lever presses0.20.20.60.40.6-0.80.60.50.1-0.50.4-0.5-0.10.10.4
Short access day 10 total inactive lever presses0.10.10.30.20.3-0.30.4-0.10.4-0.30.20.30.50.10.1
Short access day 1 total infusions0.40.42.00.2-0.0-0.30.3-0.4-0.6-0.1-0.3-1.4-0.9-0.80.8
Short access day 10 total infusions0.30.31.10.40.5-0.40.50.60.4-0.40.50.90.50.5-1.1
Short access total infusions0.10.10.30.50.4-0.40.60.30.0-0.40.2-0.2-0.1-0.1-0.5
Short access day 1 locomotion0.10.10.30.20.1-0.20.4-0.1-0.3-0.20.00.2-0.2-0.3-0.5
Short access day 10 total locomotion3.33.76.82.62.4-2.52.51.31.6-2.21.71.41.61.5-0.9
Short access total locomotion3.43.67.92.82.3-2.42.81.31.3-2.41.50.81.31.3-0.9
One hour access (0.3 mA shock)0.10.10.40.60.4-0.40.50.20.2-0.30.30.40.20.2-0.6
Compulsive drug intake0.30.30.8-0.2-0.70.6-0.6-0.9-0.60.6-0.6-0.1-0.5-0.5-0.1
One hour access (shock baseline)0.10.10.30.40.5-0.50.60.40.1-0.30.40.10.10.0-0.4
Social response proportion0.30.31.5-1.2-0.30.8-0.80.1-0.20.6-0.40.5-0.0-0.0-0.7
Social responses0.60.71.8-0.10.8-0.40.31.11.3-0.70.60.91.31.3-0.1
Social time0.50.71.40.71.2-0.71.00.70.8-1.00.40.90.90.9-0.8
Soleus weight0.61.82.91.61.2-1.61.21.41.6-1.21.70.81.51.0-0.8
Bone: stiffness0.40.72.0-0.5-1.20.5-1.3-0.5-0.31.40.40.6-0.1-0.8-0.9
Tibialis anterior weight5.819.727.14.24.4-4.14.04.35.0-4.14.45.15.24.5-3.7
Time to tail flick, vehicle, before self-admin0.30.31.40.2-0.20.10.1-0.2-0.3-0.2-0.4-1.2-0.5-0.21.0
Time to tail flick, vehicle, after self-admin0.91.02.91.11.0-1.31.00.50.4-1.10.4-1.7-0.10.21.5
Time to tail flick, test, before self-admin1.31.32.1-1.0-1.11.0-1.1-1.0-1.31.1-1.0-1.4-1.4-1.20.9
Time to tail flick, test, after self-admin0.30.30.70.70.5-0.40.60.50.5-0.60.40.70.60.6-0.8
Delta time to tail flick, vehicle, before/after SA0.10.10.50.30.6-0.70.30.20.2-0.30.4-0.00.20.00.0
Delta time to tail flick, test, before/after SA1.61.42.41.01.0-0.71.01.21.4-1.10.91.51.51.5-1.2
Tibia length0.10.31.4-0.8-0.70.5-1.20.00.11.00.10.20.2-0.10.2
Ambulatory time before self-admin0.30.30.80.80.6-0.70.70.20.2-0.60.2-0.40.10.10.9
Ambulatory time after self-admin1.82.05.40.71.3-0.90.91.71.5-0.91.42.31.71.7-1.1
Bone: tissue strength1.81.72.4-1.5-1.61.3-1.6-1.4-1.11.5-1.1-1.1-1.1-1.31.3
Total heroin consumption1.61.83.4-0.5-1.20.9-0.6-1.8-1.71.0-1.4-1.4-1.6-1.91.3
Bone: trabecular number0.71.11.70.91.2-0.71.11.21.1-1.20.71.21.01.3-0.9
Bone: trabecular spacing0.50.71.2-0.6-1.00.2-1.0-1.0-0.71.0-0.2-1.0-0.6-1.11.0
Bone: trabecular thickness2.83.37.11.01.3-1.00.72.22.1-0.81.92.62.21.9-2.7
Bone: trabecular tissue density0.30.41.4-0.4-0.90.1-1.2-0.20.01.00.4-0.60.0-0.50.3
Water consumed over 24 hours2.53.04.9-1.9-2.21.8-2.0-1.9-1.92.2-1.10.2-1.6-1.8-0.7
Number of responses in last shaping day0.00.00.40.10.0-0.10.1-0.1-0.2-0.00.00.0-0.2-0.0-0.6