Ccdc88b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Ccdc88b	0.09	0.05	4.1e-08	0.06	0.07	0.07	0.06	5.3e-07	4.2e-08	3.1e-08	2.6e-07
2	NAcc	gene expression	Ccdc88b	0.06	0.04	1.6e-05	0.03	0.03	0.03	0.03	2.3e-04	2.1e-04	2.3e-04	1.8e-04
3	RMTg	alternative polyA	XM_215206.11	0.22	0.13	3.9e-03	0.01	0.02	0.07	0.05	2.2e-01	9.8e-02	7.1e-03	1.9e-02
4	Adipose	gene expression	Ccdc88b	0.1	0.05	4.7e-07	0.05	0.05	0.05	0.05	1.7e-06	2.2e-06	1.1e-06	5.2e-06
5	Brain	mRNA stability	Ccdc88b	0.08	0.05	1.9e-06	0.03	0.05	0.05	0.05	9.9e-04	8.1e-06	9.5e-06	1.1e-05
6	Brain	gene expression	Ccdc88b	0.57	0.13	0.0e+00	0.33	0.33	0.37	0.09	4.9e-31	7.5e-32	5.7e-36	1.7e-08
7	OFC	gene expression	Ccdc88b	0.14	0.09	5.5e-03	0.06	0.09	0.12	0.07	1.5e-02	4.8e-03	1.0e-03	8.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.6	0.9	3.0	-0.5	1.0	0.9	-1.7	0.5	0.9	0.7
Area under the delay curve	0.4	0.4	1.4	0.3	-0.3	-0.1	-0.1	0.0	1.1	1.2
BMI with tail	2.8	8.9	21.3	-1.6	3.2	4.6	-4.3	-0.2	2.3	2.0
BMI without tail	1.1	2.2	6.1	-1.0	1.6	2.5	-1.6	-0.9	1.3	0.8
Body weight	2.3	9.4	20.5	-3.2	4.2	4.5	-3.6	-2.0	0.1	0.2
Weight adjusted by age	2.0	2.2	5.4	-1.9	1.7	2.3	-1.2	-0.8	-1.0	-1.0
Bone surface	3.6	6.4	14.6	-2.8	3.5	3.2	-3.8	0.1	-0.1	-0.3
Bone volume	2.0	3.4	10.0	-1.8	2.4	1.9	-3.2	0.9	0.2	0.0
Breakpoint value in progressive ratio session	2.2	2.4	4.5	-2.1	2.1	1.2	-1.4	-1.0	-1.4	-1.3
Number of licking bursts	0.3	0.3	1.0	-0.8	0.7	1.0	-0.4	-0.2	-0.4	-0.1
Context. condit. distance diff. score	1.1	1.4	2.8	1.7	-1.4	-1.0	0.7	0.8	1.2	1.2
Locomotion velocity, session 1	0.3	0.3	1.0	0.4	-0.5	0.3	0.1	-0.3	1.0	0.8
Locomotion distance, session 1	0.7	0.8	2.1	0.1	0.0	1.0	-0.9	-0.2	1.5	1.3
Locomotion velocity, session 2	1.3	1.5	3.7	-1.4	1.3	1.9	-1.5	-1.1	-0.0	0.1
Locomotion distance, session 2	0.3	0.4	0.8	-0.2	0.0	0.7	-0.4	-0.7	0.9	0.7
Locomotion velocity, session 3	2.3	2.7	7.9	1.4	-0.9	0.2	-0.7	1.2	2.5	2.8
Locomotion distance, session 3	0.2	0.2	0.7	0.5	-0.3	0.3	-0.1	0.2	0.7	0.8
Stereotopy head waving bouts, day 3	2.4	2.9	7.0	1.8	-1.4	-0.3	-0.3	1.1	2.6	2.6
Stereotopy head waving duration, day 3	1.1	1.3	2.4	1.3	-1.0	-0.6	0.1	1.1	1.5	1.5
Locomotion velocity, session 7	1.4	1.5	3.1	1.2	-0.9	-1.0	-0.4	1.2	1.7	1.7
Locomotion distance, session 7	0.8	1.0	2.3	1.0	-1.0	-0.4	0.4	0.1	1.4	1.5
Stereotopy head waving bouts, day 7	0.4	0.4	1.6	-0.0	0.4	0.1	-1.1	1.2	0.4	0.1
Stereotopy head waving duration, day 7	1.3	1.6	3.2	-1.4	1.8	1.5	-1.8	0.1	-0.5	-0.7
Locomotion velocity, session 8	0.3	0.3	1.4	-0.4	0.2	0.7	-0.1	-1.2	0.4	0.0
Locomotion distance, session 8	0.8	1.2	3.5	0.9	-0.6	-0.1	-0.8	0.9	1.9	1.6
Degree of sensitization distance	0.7	0.7	2.2	0.7	-0.6	-0.4	-0.2	0.4	1.3	1.5
Degree of sensitization stereotypy	1.1	1.2	2.9	-1.2	1.5	0.9	-1.7	0.6	-0.4	-0.7
Conditioned locomotion	0.7	0.8	2.2	-1.1	0.9	1.5	-0.5	-1.0	-0.2	-0.3
Cocaine response after cond. corrected	1.8	2.0	3.8	2.0	-1.7	-0.7	1.1	0.5	1.6	1.6
Cocaine response after cond. not corrected	1.3	1.5	2.9	1.7	-1.3	-0.9	0.9	0.5	1.5	1.3
Cocaine response before conditioning	1.0	1.2	2.1	-1.3	1.4	0.2	-0.9	-0.3	-1.1	-1.5
Saline control response	2.2	2.8	6.0	-2.0	1.8	2.5	-0.8	-2.1	-0.8	-1.0
Bone: connectivity density	1.5	2.4	5.1	-1.7	2.1	2.1	-2.3	-0.4	0.3	0.3
Bone: cortical apparent density	0.6	0.8	1.9	-0.6	0.3	-0.1	0.7	-1.1	-1.2	-1.4
Bone: cortical area	0.6	0.9	2.0	-1.2	1.4	0.8	-1.4	0.0	-0.5	-0.3
Bone: cortical porosity	0.1	0.1	0.2	-0.1	0.3	-0.2	-0.2	-0.1	-0.2	-0.4
Bone: cortical porosity	0.3	0.3	0.6	-0.6	0.8	0.1	-0.3	-0.6	-0.6	-0.8
Bone: cortical thickness	1.9	3.0	6.3	-2.0	1.7	1.1	0.1	-2.5	-1.9	-1.7
Bone: cortical thickness	0.4	0.5	2.6	-0.2	0.0	0.4	0.7	-1.6	-0.3	-0.2
Bone: cortical tissue density	0.7	1.0	2.2	-0.7	0.3	-0.0	0.7	-1.3	-1.3	-1.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.3	0.1	-0.1	0.2	-0.5	-0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.8	-0.3	0.1	-0.3	0.7	-0.5	-0.8	-0.9
Condit. Reinf. active responses	0.1	0.1	0.3	-0.0	0.0	-0.3	-0.2	0.2	0.1	0.5
Condit. Reinf. inactive responses	0.6	0.7	1.6	0.5	-0.1	-0.2	-0.9	1.1	1.0	1.3
Incentive salience index mean	0.1	0.1	0.2	-0.3	0.3	0.3	-0.3	-0.3	0.2	0.5
Condit. Reinf. lever presses	0.3	0.4	1.1	-0.5	0.6	0.7	-1.0	0.2	0.4	0.7
Condit. Reinf. active minus inactive responses	0.3	0.4	1.4	0.1	0.3	-1.0	-0.6	1.2	0.0	-0.4
Condit. Reinf. active-inactive response ratio	1.3	1.3	5.3	0.5	0.2	-1.3	-1.2	2.3	0.7	0.1
Condit. Reinf. active responses	0.1	0.2	0.3	-0.3	0.6	-0.4	-0.5	0.3	-0.3	-0.4
Condit. Reinf. inactive responses	0.3	0.4	1.9	-0.5	0.2	0.3	0.5	-1.4	-0.5	-0.3
Condit. Reinf. lever presses	1.8	2.5	5.3	-2.1	2.3	1.4	-2.2	-0.0	-0.7	-0.9
Condit. Reinf. lever reinforcers received	0.3	0.5	1.0	-0.8	1.0	-0.0	-0.8	0.1	-0.6	-0.8
Conditioned reinforcement - actives	0.3	0.3	1.6	-0.1	0.3	0.2	-0.8	1.3	-0.0	-0.1
Conditioned reinforcement - inactives	1.7	1.9	6.7	1.5	-1.3	-1.7	0.4	2.6	0.3	0.3
Conditioned locomotion	3.2	3.9	7.1	2.6	-2.2	-2.4	1.5	2.7	0.7	0.6
Patch foraging indifference point 0 sec	0.1	0.2	0.4	0.1	0.6	-0.4	0.3	0.2	-0.4	-0.5
Patch foraging indifference point AUC	3.0	3.5	6.6	-2.6	2.3	1.8	-1.8	-1.0	-1.7	-1.4
Delay disc. indifference point, 0s delay	1.7	1.9	6.2	1.1	-0.7	0.7	-0.2	0.2	2.2	2.5
Delay disc. indifference point, 16s delay	0.5	0.5	1.6	0.7	-0.6	-1.3	0.1	1.0	0.5	0.3
Delay disc. indifference point, 2s delay	0.5	0.6	1.6	0.3	-0.4	0.0	-0.5	0.6	1.3	1.2
Delay disc. indifference point, 24s delay	0.5	0.5	1.3	0.4	-0.8	-0.6	1.2	-0.8	0.1	-0.1
Delay disc. indifference point, 4s delay	0.7	0.7	2.1	0.7	-0.6	-0.2	0.5	-0.5	1.2	1.5
Delay disc. indifference point, 8s delay	0.5	0.5	1.4	0.5	-0.6	0.1	0.4	-0.4	1.1	1.2
Indifference point function ln k	6.8	9.5	17.6	4.2	-3.9	-3.2	3.0	1.5	2.7	2.1
Indifference point function log k	6.8	9.5	17.6	4.2	-3.9	-3.2	3.0	1.5	2.7	2.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	0.1	0.5	-0.4	0.7	-0.3	-0.6	-0.6
Patch foraging total patch changes 12 sec	3.7	4.8	9.8	-2.8	3.1	2.2	-1.7	-1.6	-1.9	-1.5
Patch foraging total patch changes 18 sec	0.9	1.1	2.9	-1.2	1.7	0.6	-0.8	-0.4	-1.1	-1.1
Patch foraging total patch changes 24 sec	2.1	2.5	4.5	-2.1	2.1	1.6	-1.1	-1.4	-1.6	-0.8
Patch foraging total patch changes 6 sec	0.4	0.6	1.2	-0.8	1.1	1.0	-0.5	-0.8	-0.2	-0.2
Patch foraging time to switch 0 sec	1.5	2.4	6.2	-1.3	1.5	2.2	-2.5	0.2	0.7	0.9
Patch foraging water rate 0 sec	2.5	4.0	11.2	2.0	-2.1	-3.4	2.7	0.8	-0.3	-0.7
Patch foraging water rate 12 sec	5.4	8.3	15.4	3.6	-3.8	-3.6	3.9	0.7	0.9	0.9
Patch foraging water rate 18 sec	2.9	3.9	6.6	2.6	-2.5	-2.4	2.3	0.4	1.3	1.1
Patch foraging water rate 24 sec	2.3	3.2	5.7	2.4	-2.2	-2.3	2.3	0.7	0.8	0.0
Patch foraging water rate 6 sec	3.8	5.6	11.3	2.8	-3.0	-3.4	3.1	0.2	0.8	0.7
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.4	-0.5	-0.4	0.6	-0.1	-0.0	-0.1
Distance traveled before self-admin	0.9	0.9	2.2	-1.2	1.5	0.6	-1.2	0.2	-0.7	-0.7
Distance traveled after self-admin	0.5	0.6	1.1	-0.9	1.0	0.2	-0.5	-0.0	-1.1	-0.9
Extensor digitorum longus weight	3.7	14.8	25.6	-4.8	5.0	5.1	-3.9	-3.4	-1.4	-1.2
Bone: elastic displacement	1.6	1.8	4.7	1.5	-1.9	-1.4	2.2	-0.6	-0.0	0.0
Bone: elastic work	0.4	0.6	3.3	-0.2	-0.0	0.2	0.7	-1.8	-0.4	-0.1
Bone: endosteal estimation	2.0	4.4	8.4	1.6	-1.0	-0.1	-1.7	2.7	2.9	2.9
Bone: endosteal perimeter	2.3	4.7	12.2	1.4	-0.5	-0.4	-2.3	3.5	2.7	2.4
Epididymis fat weight	1.5	3.5	7.1	2.3	-0.7	-2.0	-0.3	2.7	1.7	2.2
Delta time in closed arm before/after self-admin	1.3	1.3	2.2	1.2	-1.1	-1.2	1.5	-1.1	0.9	0.9
Delta time in open arm before/after self-admin	1.4	1.3	2.0	-1.4	1.3	0.9	-0.9	0.3	-1.4	-1.4
Diff in mean of infusions in LGA sessions	1.1	1.2	2.1	-0.8	1.2	-1.3	0.1	-0.8	-1.5	-1.2
Delay discount exponential model param	0.3	0.3	1.0	-0.2	0.3	0.1	-0.0	0.1	-1.0	-1.0
Extinction: sum of active levers before priming	2.8	2.8	5.1	-2.2	2.2	1.6	-2.0	-1.2	-1.1	-0.7
Active lever presses in extinction session 6	3.2	3.1	6.3	-2.2	2.5	1.1	-1.4	-0.7	-1.9	-1.8
Bone: final force	1.8	2.9	6.1	-2.0	2.3	2.2	-2.5	-0.7	-0.2	0.0
Bone: final moment	1.6	2.7	5.7	-1.9	2.2	2.1	-2.4	-0.6	-0.2	0.0
Food consumed during 24 hour testing period	0.6	0.8	2.0	-0.9	0.7	1.4	-0.3	0.0	-1.0	-1.0
Glucose	1.9	2.9	5.1	2.0	-1.6	-0.5	-0.2	2.2	2.3	1.9
Heart weight	2.6	3.7	6.9	2.6	-2.1	-1.8	1.3	1.4	1.8	2.1
Delay discount hyperbolic model param	0.3	0.4	1.2	-0.2	0.3	0.0	0.1	0.1	-1.1	-1.1
Intermittent access intake day 1-15 change	0.4	0.4	0.9	-0.1	0.5	-0.2	-0.1	0.9	-0.9	-0.9
Intermittent access intake escalation	0.3	0.3	0.8	-0.0	0.6	-0.4	-0.1	0.9	-0.8	-0.7
Intermittent access intake escalation 2	0.7	0.7	1.8	-0.5	0.9	-0.3	-0.2	0.6	-1.3	-1.2
Intermitt. access day 1 inactive lever presses	1.4	1.5	3.6	1.3	-1.2	-1.9	0.4	1.6	0.7	0.7
Intermitt. access day 15 inactive lever presses	1.7	1.9	5.3	1.2	-0.8	-2.3	-0.2	2.3	0.4	0.6
Intermitt. access escalation Index	2.2	2.0	4.2	2.1	-1.9	-0.5	1.4	0.6	1.4	1.2
Intermittent access day 1 total infusions	5.2	6.0	10.9	2.8	-1.6	-0.7	-0.6	3.3	3.1	3.2
Intermittent access day 15 total infusions	3.9	4.4	13.5	2.6	-1.1	-1.5	-0.3	3.7	1.9	2.0
Intermittent access terminal intake (last 3 days)	3.6	3.9	13.2	2.0	-0.2	-1.1	-1.2	3.6	1.9	2.0
Intermittent access total infusions	3.6	3.9	11.2	2.2	-0.8	-0.8	-0.8	3.3	2.2	2.2
Intermittent access day 1 locomotion	4.6	4.8	10.2	2.6	-1.3	-0.1	-0.2	2.3	3.1	3.2
Intermittent access day 15 total locomotion	2.2	2.3	7.8	1.8	-0.6	-1.2	-0.3	2.8	1.3	1.4
Intermittent access total locomotion	4.8	5.4	14.4	2.5	-0.8	-1.0	-1.1	3.8	2.6	2.8
Intermittent access standard deviation	0.3	0.4	1.5	0.6	0.2	-0.6	0.2	1.2	-0.3	-0.3
Left kidney weight	0.2	0.7	2.2	0.8	-0.3	-1.2	-0.2	1.5	0.5	0.3
Right kidney weight	0.2	0.7	2.4	-0.2	0.7	-0.5	-1.2	1.5	-0.2	0.1
Cocaine induced anxiety	0.3	0.3	0.8	-0.5	0.3	-0.8	-0.9	0.5	-0.0	0.0
Post-drug Anxiety	1.1	1.2	2.6	-1.5	1.4	0.9	-1.6	-0.0	-0.7	-0.6
Baseline Anxiety	1.6	1.7	3.4	-1.3	1.6	1.8	-0.5	-1.5	-1.0	-0.8
Tail length	0.7	2.2	6.0	-1.6	0.9	0.4	0.7	-2.4	-1.6	-1.7
Length with tail	1.1	4.0	7.6	-2.8	2.5	1.9	-1.2	-2.4	-1.6	-1.1
Length without tail	1.0	2.1	4.6	-1.8	2.1	1.6	-1.8	-1.0	-0.7	-0.2
Times rat made contact with spout	0.5	0.6	1.7	-0.6	0.2	0.3	0.7	-1.3	-0.7	-0.8
Lifetime Intake	3.5	3.9	8.7	2.3	-0.8	-1.2	-0.6	3.0	2.3	2.4
Liver weight, left	0.2	0.3	1.1	0.5	-0.1	-0.7	-0.3	0.6	1.0	0.3
Liver weight, right	0.6	1.1	3.4	0.9	-0.5	0.1	-0.4	0.2	1.7	1.8
Locomotor activity	1.8	2.8	6.1	2.0	-1.9	-2.5	2.4	-0.0	0.5	0.5
Locomotor testing distance	2.6	4.4	8.5	2.6	-2.6	-2.6	2.9	-0.2	1.0	1.1
Locomotor testing rearing	1.9	3.0	5.3	2.3	-2.0	-2.0	2.2	0.2	1.0	1.3
Locomotion in novel chamber	1.7	2.1	8.2	1.7	-1.1	-1.0	-0.2	2.9	0.9	1.0
Locomotion in novel chamber post-restriction	1.7	2.1	4.4	1.7	-1.6	-2.1	0.7	1.7	0.9	0.7
Fecal boli incidents, locomotor time 1	1.0	1.1	2.4	-1.1	1.2	1.0	-1.6	1.0	-0.4	-0.4
Change in fecal boli incidents, locomotor task	1.5	1.5	2.5	1.2	-1.5	-0.3	1.0	-0.7	1.6	1.5
Time >=10cm from walls, locomotor time 1	2.0	2.0	5.5	0.7	0.2	-0.3	-1.8	2.3	1.4	1.5
Bouts of movement, locomotor time 1	3.6	3.9	9.3	-2.0	1.6	0.1	0.5	-1.6	-3.0	-3.0
Total resting periods, locomotor time 1	2.9	3.2	7.8	-1.9	1.6	0.1	0.2	-1.2	-2.8	-2.7
Rest time, locomotor task time 1	1.1	1.2	3.9	0.9	-1.1	-2.0	1.3	0.6	-0.3	-0.5
Distance moved, locomotor task time 1	0.6	0.7	1.6	-0.1	0.7	1.3	-1.1	0.2	0.7	1.0
Vertical activity count, locomotor time 1	0.9	1.0	1.8	1.3	-0.8	-0.5	0.2	1.1	1.2	1.2
Time >=10cm from walls, locomotor time 2	0.5	0.6	0.9	-0.7	0.9	-0.5	-0.6	0.5	-0.9	-0.9
Bouts of movement, locomotor time 2	0.7	0.7	1.4	-0.9	0.7	0.8	0.0	-0.8	-1.2	-1.0
Total resting periods, locomotor time 2	0.3	0.4	0.7	-0.6	0.5	0.7	-0.0	-0.4	-0.9	-0.7
Rest time, locomotor task time 2	1.9	2.2	3.8	2.0	-1.6	-1.5	0.7	1.5	1.4	1.3
Distance moved, locomotor task time 2	1.2	1.4	2.1	-1.4	1.4	0.9	-0.4	-1.1	-1.3	-1.2
Vertical activity count, locomotor time 2	0.6	0.6	1.8	0.3	-0.5	-0.7	1.3	-1.0	-0.6	-0.7
Light reinforcement 1	0.4	0.6	1.5	0.2	-0.1	-1.2	1.1	-0.1	-0.7	-1.1
Light reinforcement 2	0.7	0.9	4.6	0.4	-0.1	-0.8	-0.8	2.1	0.0	0.4
Bone: marrow area	2.1	4.5	8.7	1.7	-1.1	-0.2	-1.6	2.7	2.9	2.9
Bone: maximum diameter	0.7	1.3	4.2	-1.0	1.4	0.7	-2.1	1.2	0.1	0.1
Bone: maximum force	2.6	4.5	13.2	-2.1	2.7	2.4	-3.6	0.2	0.5	0.8
Bone: maximum moment	2.2	3.9	11.6	-1.9	2.5	2.2	-3.4	0.1	0.5	0.8
Mean time between licks in bursts	0.5	0.8	3.7	0.0	-0.3	0.7	1.0	-1.9	-0.1	0.1
Mean num. licks in bursts	0.4	0.5	1.3	0.6	-0.8	-1.1	1.0	-0.4	-0.0	-0.4
Cd content in liver	0.5	0.5	1.9	0.3	-0.4	-1.2	-0.2	1.4	-0.1	-0.2
Co content in liver	2.4	2.8	9.6	1.3	-1.9	-1.6	3.1	-1.0	-0.6	-0.8
Cu content in liver	0.2	0.3	0.6	-0.7	0.4	0.4	0.0	-0.5	-0.7	-0.6
Fe content in liver	0.2	0.3	1.0	-0.5	0.7	0.1	-1.0	0.4	0.1	0.0
K content in liver	0.8	0.8	1.7	-0.7	0.9	1.3	-1.2	-0.3	0.9	0.8
Mg content in liver	0.5	0.6	1.8	0.3	-0.0	0.5	-0.6	0.5	1.1	1.3
Mn content in liver	2.1	2.3	4.9	-1.9	2.2	1.6	-1.8	-0.4	-1.2	-0.7
Na content in liver	0.7	0.7	1.6	-1.1	1.1	1.2	-0.9	-0.3	-0.3	-0.1
Rb content in liver	1.6	2.0	3.4	1.8	-1.6	-1.5	0.5	1.2	1.5	1.4
Se content in liver	0.7	0.9	1.9	-0.8	1.1	-0.1	-1.4	1.3	-0.7	-0.6
Sr content in liver	3.3	3.1	5.1	-2.3	2.1	1.8	-0.8	-1.5	-1.9	-1.6
Zn content in liver	1.1	1.2	2.4	-1.2	1.5	1.6	-0.9	-0.6	-0.9	-0.3
Bone: minimum diameter	1.7	3.1	6.0	1.3	-0.8	-0.4	-1.5	2.3	2.3	2.5
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.6	-0.4	-0.2	0.0	0.4	0.5	0.6
Time in novel zone, hab. session 1	0.4	0.4	0.9	0.7	-0.9	-0.4	1.0	-0.3	0.5	0.4
Total zone transitions, hab. session 1	0.2	0.3	0.8	-0.9	0.7	0.6	-0.6	-0.4	-0.2	-0.3
Total locomotion distance, hab. session 1	0.6	0.8	1.9	0.9	-0.7	-0.5	-0.3	1.1	1.4	1.1
Locomotion velocity, hab. session 1	0.2	0.2	0.6	0.3	-0.2	-0.2	-0.3	0.5	0.8	0.6
Time in familiar zone, hab. session 2	0.6	0.6	2.0	0.5	-0.7	-0.3	1.4	-1.3	0.1	-0.0
Time in novel zone, hab. session 2	0.4	0.4	1.2	-0.4	0.4	0.7	-1.1	0.7	0.1	0.4
Total zone transitions, hab. session 2	0.7	0.9	1.9	-0.6	0.8	1.4	-1.2	-0.4	0.9	0.9
Total locomotion distance, hab. session 2	0.7	1.0	2.9	0.8	-0.6	0.4	-0.4	0.4	1.7	1.5
Locomotion velocity, hab. session 2	0.8	1.1	3.1	0.8	-0.6	0.2	-0.6	0.8	1.8	1.5
Novel to familiar place preference ratio	2.1	2.1	4.3	-1.8	2.1	1.4	-2.0	0.3	-1.0	-0.7
Novelty place preference	1.4	1.4	2.9	-1.4	1.6	1.1	-1.7	0.5	-0.9	-0.6
Time in novel zone, NPP test	1.0	1.1	2.4	-1.2	1.4	1.0	-1.6	0.4	-0.7	-0.3
Total zone transitions, NPP test	1.2	1.7	3.4	-1.5	1.7	1.9	-1.7	-0.7	0.1	-0.2
Total locomotion distance, NPP test	0.4	0.5	1.7	0.4	-0.2	0.3	-0.5	0.3	1.3	1.1
Locomotion velocity, NPP test	0.2	0.3	0.9	0.1	-0.1	0.5	-0.5	0.2	1.0	0.7
Intraocular pressure	0.9	1.3	3.3	-0.2	0.2	-1.3	0.4	1.0	-1.7	-1.8
Delta distance traveled before/after self-admin	0.2	0.2	0.6	0.4	-0.5	-0.5	0.8	-0.4	0.0	0.1
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	0.4	-0.7	-0.0	0.8	-0.6	0.3	0.4
Parametrial fat weight	1.6	3.1	6.2	2.0	-1.2	-0.9	-0.6	2.5	2.5	1.7
Pavlov. Cond. lever latency	0.3	0.4	1.0	0.6	-0.5	-0.8	1.0	0.1	-0.2	-0.7
Pavlov. Cond. magazine entry latency	0.4	0.6	1.3	-0.6	0.8	0.9	-1.1	0.2	0.2	0.9
Pavlov. Cond. change in total contacts	0.5	0.5	1.4	-0.8	0.7	0.6	-1.2	0.8	-0.3	0.0
Pavlov. Cond. index score	0.3	0.3	0.6	-0.8	0.7	0.7	-0.7	-0.1	-0.5	-0.1
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.5	0.4	0.6	-0.6	-0.1	-0.1	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.1	-0.1	0.3	-0.3	-0.1	0.3	0.5
Pavlov. Cond. magazine entry number	0.6	0.8	1.5	1.2	-1.2	-0.6	0.7	0.1	1.1	0.7
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.5	0.2	-0.4	-1.2	0.7	0.4	-1.1	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.0	-1.0	0.9	0.9	-0.9	-0.2	-0.5	-0.1
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.8	0.7	0.4	-0.6	-0.0	-0.6	-0.1
Pavlov. Cond. lever latency	0.8	1.0	3.1	1.1	-1.5	-0.7	1.8	-0.4	0.2	0.2
Pavlov. Cond. magazine entry latency	2.7	3.1	6.5	-2.3	2.6	1.8	-1.5	-1.3	-1.3	-1.0
Pavlov. Cond. change in total contacts	2.6	3.6	7.5	-2.3	2.7	1.4	-2.7	0.4	-1.3	-1.0
Pavlov. Cond. index score	2.5	3.2	7.3	-2.3	2.7	1.6	-2.3	-0.2	-1.1	-0.9
Pavlov. Cond. latency score	2.1	2.6	6.2	-2.0	2.5	1.4	-2.3	-0.0	-0.8	-0.7
Pavlov. Cond. lever contacts	0.8	1.1	2.5	-1.3	1.6	0.5	-1.2	0.1	-0.9	-0.9
Pavlov. Cond. magazine entry number	5.0	6.1	12.5	3.2	-3.5	-2.5	2.6	1.3	1.9	1.4
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.8	1.1	-1.1	-1.3	0.7	0.8	0.6	0.0
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.6	7.9	-2.4	2.8	1.8	-2.3	-0.5	-1.2	-1.1
Pavlov. Cond. response bias	1.9	2.6	5.7	-2.1	2.4	1.4	-1.9	-0.4	-1.2	-1.1
Time in closed arm before self-admin	0.6	0.7	1.7	-0.8	0.6	1.3	-1.3	0.7	-0.0	-0.0
Time in closed arm after self-admin	0.6	0.6	1.0	0.9	-1.0	-0.6	0.6	-0.1	1.0	0.9
Time in open arm before self-admin	2.1	2.3	5.3	1.7	-1.8	-1.5	2.3	-1.1	0.8	0.7
Time in open arm after self-admin	0.5	0.6	1.4	-0.2	-0.1	-0.1	1.1	-0.6	-1.1	-1.2
Bone: periosteal estimation	0.9	1.9	4.8	0.1	0.4	0.5	-2.2	1.9	1.5	1.6
Bone: periosteal perimeter	0.7	1.1	3.8	-0.4	0.9	0.6	-1.9	1.3	0.8	0.7
Bone: post-yield work	3.3	4.4	14.5	-0.4	1.3	0.9	-3.8	2.7	2.0	1.6
Progressive ratio test 1 active lever presses	1.7	1.8	3.5	1.6	-1.3	-1.7	0.5	1.9	0.9	0.9
Progressive ratio test 1 breakpoint	1.3	1.4	3.0	1.4	-1.2	-1.3	0.4	1.7	0.8	0.8
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.1	1.1	-0.6	-0.7	0.6	0.7	0.5	0.6
Progressive ratio test 2 active lever presses	2.4	2.6	7.8	1.8	-1.1	-1.8	-0.1	2.8	1.2	1.2
Progressive ratio test 2 breakpoint	2.7	3.0	7.3	2.1	-1.6	-2.2	0.6	2.7	1.0	0.9
Progressive ratio test 2 inactive lever presses	3.4	3.9	12.1	2.4	-1.3	-2.2	0.2	3.5	1.2	1.3
Incentive Sensitization - Responses	0.3	0.3	1.7	0.3	0.1	-0.5	-0.5	1.3	0.2	0.2
Incentive Sensitization - Breakpoint	0.4	0.4	2.1	0.5	-0.0	-0.6	-0.4	1.5	0.2	0.3
Sum of active levers in priming session hrs 5-6	3.8	3.7	6.4	-2.3	2.4	1.1	-1.3	-0.1	-2.5	-2.4
Progressive ratio	1.9	2.2	5.3	-1.5	1.7	2.1	-2.3	-0.1	0.3	0.6
Food seeking constrained by brief footshock	0.3	0.4	1.0	0.1	-0.3	1.0	0.5	-0.9	0.3	0.5
Seeking ratio, punishment vs. effort	2.1	2.6	7.7	1.8	-2.2	-1.5	2.8	-0.5	0.2	0.1
Retroperitoneal fat weight	3.2	10.6	18.3	4.3	-3.1	-3.5	0.9	4.1	3.0	2.8
Reaction time number correct	0.2	0.3	0.7	-0.6	0.6	-0.1	-0.1	-0.8	-0.7	-0.5
Reaction time mean minus median	2.9	3.8	6.5	-2.4	2.5	2.3	-2.5	-0.3	-1.1	-1.1
Reaction time mean minus median AUC	1.8	2.3	3.8	-1.9	2.0	1.7	-1.4	-0.6	-1.2	-1.4
Reaction time num false alarms	1.2	1.6	4.4	1.4	-1.5	-1.1	2.1	-1.0	0.4	0.3
Reaction time num false alarms AUC	0.7	0.9	2.8	0.7	-0.8	-0.6	1.7	-1.5	0.0	-0.1
Reaction time trials correct on left	0.2	0.3	0.7	-0.6	0.6	-0.1	-0.1	-0.8	-0.7	-0.5
Reaction time trials on left	0.3	0.4	0.8	-0.7	0.7	0.0	-0.2	-0.9	-0.8	-0.6
Reaction time mean	0.3	0.5	0.9	-0.6	0.9	0.4	-1.0	0.7	-0.5	-0.5
Reaction time mean AUC	0.4	0.5	1.0	-0.6	0.9	0.4	-1.0	0.8	-0.5	-0.5
Median of all reaction times	0.2	0.2	0.9	-0.2	0.5	-0.0	-0.7	0.9	-0.1	-0.1
Reaction time omissions	0.9	1.2	2.2	-1.2	1.5	1.2	-0.6	-0.8	-1.1	-1.1
Reaction time false alarm rate	0.8	1.1	2.6	1.3	-1.3	-0.6	1.6	-0.7	0.6	0.5
Reaction time premature initiation rate	1.0	1.3	6.2	-0.9	0.1	1.2	0.3	-2.5	-0.2	0.3
Reaction time premature initiations	1.6	2.3	9.5	-1.6	0.7	1.4	0.2	-3.1	-1.1	-0.5
Std. dev. reaction times	0.9	1.2	1.9	-1.4	1.4	1.0	-1.3	0.0	-1.0	-1.1
Reaction time trials completed	0.3	0.4	0.8	-0.7	0.7	0.0	-0.2	-0.9	-0.8	-0.6
Reaction time trials AUC	0.1	0.2	0.6	-0.4	0.5	-0.1	-0.0	-0.8	-0.5	-0.4
Run reversals in cocaine runway, females	1.0	1.0	2.8	0.7	-0.5	0.5	0.1	-0.8	1.7	1.6
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.3	-0.5	-0.3	0.3	0.0	0.2	0.2
Latency to leave start box in cocaine runway	0.7	0.7	1.4	0.5	-0.5	1.1	-0.5	0.8	1.2	1.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.7	-0.1	0.1	0.8	-0.2	0.3	0.2	-0.1
Latency to leave start box in cocaine runway, M	1.0	0.9	2.1	0.7	-0.8	0.8	-0.5	0.7	1.4	1.4
Std. dev. time between licks in bursts	0.8	0.9	2.1	1.0	-1.2	0.1	1.4	-1.1	0.5	0.4
Total sessions with >9 infusions	2.6	2.9	6.0	2.1	-1.0	-0.4	0.1	1.7	2.4	2.5
Short access day 1 total inactive lever presses	3.2	3.6	6.2	2.5	-1.8	-2.5	1.1	1.8	1.5	1.6
Short access day 10 total inactive lever presses	3.0	3.3	5.9	2.4	-2.4	-2.1	2.2	0.7	1.1	1.0
Short access day 1 total infusions	2.9	3.1	4.8	2.2	-1.3	-1.7	0.2	2.0	2.1	2.1
Short access day 10 total infusions	3.4	3.8	7.2	2.0	-0.7	-1.3	-0.8	2.3	2.7	2.7
Short access total infusions	2.5	2.9	5.8	1.9	-0.8	-1.0	-0.3	1.8	2.4	2.4
Short access day 1 locomotion	2.3	2.5	5.2	2.0	-0.7	0.1	-0.0	1.7	2.2	2.3
Short access day 10 total locomotion	1.4	1.6	2.9	1.6	-0.8	0.2	0.0	1.5	1.6	1.7
Short access total locomotion	1.9	2.0	4.2	1.7	-0.7	0.4	0.0	1.4	2.1	2.1
One hour access (0.3 mA shock)	4.6	5.3	11.7	3.0	-2.1	-2.3	0.8	3.4	1.7	1.7
Compulsive drug intake	2.5	2.5	8.8	-1.2	0.1	1.1	1.3	-3.0	-1.5	-1.5
One hour access (shock baseline)	4.0	4.7	17.6	2.3	-1.1	-2.0	-0.4	4.2	1.5	1.5
Social response proportion	0.7	0.8	1.7	-1.3	1.3	0.3	-1.0	-0.4	-0.6	-0.6
Social responses	0.6	0.8	1.0	-0.9	1.0	-0.8	0.2	-1.0	-1.0	-1.0
Social time	0.3	0.4	0.8	-0.6	0.8	-0.4	0.2	-0.9	-0.6	-0.7
Soleus weight	2.5	7.3	12.4	3.5	-3.5	-3.4	2.2	2.3	1.8	1.3
Bone: stiffness	2.1	3.3	8.2	-2.1	2.5	1.9	-2.9	0.2	-0.0	-0.2
Tibialis anterior weight	6.4	21.9	37.5	-6.1	6.0	5.7	-3.8	-4.1	-2.9	-2.7
Time to tail flick, vehicle, before self-admin	2.0	2.0	7.0	-0.6	0.9	2.6	-1.9	0.4	1.0	1.1
Time to tail flick, vehicle, after self-admin	1.5	1.6	4.7	-0.9	0.9	2.2	-1.2	-1.2	1.1	1.1
Time to tail flick, test, before self-admin	1.8	1.7	4.8	1.5	-0.7	0.0	-0.0	0.7	2.0	2.2
Time to tail flick, test, after self-admin	0.2	0.2	1.1	-0.4	0.4	1.0	-0.3	-0.2	-0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	1.0	-0.3	0.3	0.3	-0.1	-1.0	0.3	0.3
Delta time to tail flick, test, before/after SA	3.1	2.8	6.3	-2.0	1.1	1.1	0.1	-1.1	-2.3	-2.5
Tibia length	1.5	4.3	7.9	-2.8	2.8	1.6	-2.8	0.4	-1.7	-1.1
Ambulatory time before self-admin	1.3	1.4	3.0	-1.3	1.7	0.7	-1.5	0.6	-1.0	-1.0
Ambulatory time after self-admin	0.2	0.3	1.0	-0.3	0.4	-0.2	-0.7	1.0	-0.3	-0.3
Bone: tissue strength	0.2	0.2	0.6	-0.3	0.4	-0.6	-0.2	0.3	-0.5	-0.8
Total heroin consumption	3.7	4.3	7.7	-2.8	2.6	1.8	-1.3	-2.0	-1.9	-1.7
Bone: trabecular number	1.0	1.6	5.2	-1.0	1.4	1.3	-2.3	0.8	0.4	0.5
Bone: trabecular spacing	1.1	1.4	4.0	0.9	-1.2	-1.5	2.0	-0.9	-0.3	-0.6
Bone: trabecular thickness	0.5	0.5	1.7	0.7	-0.3	-0.3	-0.5	1.3	0.8	0.7
Bone: trabecular tissue density	1.8	2.6	7.4	1.9	-1.7	-2.7	1.4	1.5	0.3	-0.0
Water consumed over 24 hours	1.0	1.2	2.1	-1.2	0.7	1.0	0.3	-1.5	-1.4	-1.2
Number of responses in last shaping day	1.2	1.3	5.0	1.2	-0.8	-2.2	1.3	0.2	0.1	0.2