Ccdc88b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Ccdc88b	0.15	0.09	2.7e-03	0.07	0.1	0.08	0.09	7.5e-03	2.1e-03	5.1e-03	3.3e-03
2	IC	gene expression	Ccdc88b	0.06	0.04	9.9e-03	0.03	0.01	0	-0	3.2e-02	1.1e-01	2.6e-01	4.9e-01
3	pVTA	gene expression	Ccdc88b	0.1	0.06	3.3e-08	0.06	0.1	0.1	0.1	2.8e-05	9.5e-09	2.4e-08	3.7e-08
4	PL	gene expression	Ccdc88b	0.08	0.04	8.6e-08	0.07	0.06	0.06	0.06	4.9e-08	1.2e-07	7.5e-07	3.6e-07
5	NAcc	gene expression	Ccdc88b	0.05	0.03	2.1e-06	0.03	0.04	0.03	0.03	7.7e-06	3.8e-06	9.4e-06	2.7e-05
6	Adipose	gene expression	Ccdc88b	0.1	0.05	3.3e-07	0.05	0.05	0.05	0.04	2.5e-06	2.3e-06	2.6e-06	8.9e-06
7	Brain	mRNA stability	Ccdc88b	0.1	0.06	3.4e-09	0.06	0.09	0.09	0.09	1.0e-06	8.3e-09	1.2e-08	1.4e-08
8	Brain	gene expression	Ccdc88b	0.61	0.15	0.0e+00	0.34	0.35	0.39	0.22	1.7e-32	8.6e-34	2.1e-38	7.6e-20
9	Eye	intron excision ratio	chr1_213472389_213476823	0.58	0.16	2.4e-03	0.16	-0	0.07	0.12	1.7e-03	3.9e-01	2.8e-02	6.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.6	1.1	2.8	0.9	-0.9	0.3	-0.9	1.0	1.6	0.1	1.0	1.7
Area under the delay curve	0.2	0.2	1.2	-0.1	0.1	-0.2	-0.3	-0.4	0.1	-0.2	1.1	0.8
BMI with tail	2.2	7.6	24.4	2.3	-2.2	1.0	-2.6	2.4	3.8	-0.3	2.3	4.9
BMI without tail	0.4	2.1	6.8	1.2	-1.5	0.8	-1.6	0.7	1.4	-1.1	1.3	2.6
Body weight	2.3	10.2	18.8	3.4	-3.7	2.5	-3.7	2.9	3.8	-1.9	0.9	4.3
Weight adjusted by age	0.6	1.8	2.9	1.7	-1.5	1.6	-1.6	1.5	1.3	-1.0	-1.0	0.3
Bone surface	4.2	8.2	16.7	3.4	-3.1	2.3	-3.1	3.6	4.1	-0.6	-0.1	2.7
Bone volume	1.9	3.7	9.8	2.1	-1.8	1.1	-1.8	2.6	3.1	0.4	0.3	2.1
Breakpoint value in progressive ratio session	2.0	3.6	5.9	2.4	-2.0	2.2	-2.2	2.3	2.0	-1.3	-1.3	0.6
Number of licking bursts	0.1	0.3	0.6	0.7	-0.7	0.6	-0.7	0.8	0.6	-0.2	-0.4	-0.0
Context. condit. distance diff. score	1.4	1.7	2.7	-1.6	1.7	-1.6	1.4	-1.5	-1.1	0.9	1.2	-0.0
Locomotion velocity, session 1	0.2	0.2	0.9	-0.3	-0.2	-0.3	-0.0	-0.6	-0.2	-0.4	1.0	0.6
Locomotion distance, session 1	0.6	0.7	3.1	0.2	-0.8	-0.1	-0.4	0.0	0.7	-0.3	1.4	1.8
Locomotion velocity, session 2	1.7	2.0	3.5	1.6	-1.9	1.4	-1.7	1.3	1.5	-1.2	-0.0	1.4
Locomotion distance, session 2	0.3	0.5	1.2	0.4	-1.0	0.3	-0.6	0.0	0.4	-0.8	0.8	1.1
Locomotion velocity, session 3	1.6	1.9	5.8	-1.0	0.5	-1.6	0.9	-0.8	0.3	1.0	2.4	2.2
Locomotion distance, session 3	0.1	0.2	0.6	-0.3	0.2	-0.4	0.2	-0.3	-0.0	0.1	0.6	0.8
Stereotopy head waving bouts, day 3	1.9	2.3	6.9	-1.3	0.8	-1.8	1.1	-1.3	-0.2	1.0	2.6	2.1
Stereotopy head waving duration, day 3	0.9	1.1	2.0	-1.1	0.8	-1.4	1.1	-0.9	-0.3	1.1	1.4	0.9
Locomotion velocity, session 7	1.1	1.2	2.7	-0.9	0.6	-1.3	1.0	-0.7	0.1	1.1	1.6	1.7
Locomotion distance, session 7	0.5	0.6	1.9	-0.6	0.2	-0.7	0.3	-0.9	-0.4	-0.1	1.4	1.3
Stereotopy head waving bouts, day 7	0.3	0.3	1.1	0.3	0.1	-0.2	-0.1	0.7	1.0	1.0	0.3	0.6
Stereotopy head waving duration, day 7	0.9	1.1	2.6	1.3	-1.0	0.9	-1.1	1.6	1.6	0.1	-0.5	0.5
Locomotion velocity, session 8	0.5	0.6	1.6	0.7	-1.0	0.7	-1.1	0.1	0.4	-1.3	0.5	0.6
Locomotion distance, session 8	0.7	1.0	3.3	-0.7	0.6	-1.2	0.6	-0.6	0.3	0.8	1.8	1.5
Degree of sensitization distance	0.4	0.4	1.7	-0.4	-0.0	-0.6	0.2	-0.5	0.1	0.2	1.3	1.2
Degree of sensitization stereotypy	0.8	0.9	2.4	1.1	-0.7	0.7	-0.9	1.5	1.6	0.4	-0.4	0.3
Conditioned locomotion	1.0	1.1	2.3	1.2	-1.5	1.1	-1.4	0.9	0.9	-1.1	-0.2	0.6
Cocaine response after cond. corrected	1.3	1.9	3.5	-1.7	1.3	-1.6	1.4	-1.9	-1.4	0.5	1.5	0.2
Cocaine response after cond. not corrected	0.9	1.3	2.2	-1.4	1.1	-1.4	1.1	-1.5	-1.0	0.5	1.3	0.4
Cocaine response before conditioning	1.0	1.2	2.2	1.4	-0.9	1.3	-1.1	1.5	1.1	-0.4	-1.3	0.1
Saline control response	3.1	4.3	7.7	2.4	-2.5	2.5	-2.8	1.7	1.4	-2.4	-0.9	1.2
Bone: connectivity density	2.1	3.3	6.1	2.1	-2.0	1.5	-2.1	2.0	2.5	-0.8	0.4	2.0
Bone: cortical apparent density	0.3	0.5	1.8	0.3	-0.3	0.8	-0.3	0.1	-0.6	-0.8	-1.3	-1.0
Bone: cortical area	0.6	1.0	1.9	1.3	-1.1	1.0	-1.1	1.4	1.3	-0.3	-0.4	0.7
Bone: cortical porosity	0.1	0.1	0.2	0.4	-0.5	0.4	-0.3	0.3	0.2	-0.4	-0.5	0.1
Bone: cortical porosity	0.4	0.5	0.8	0.8	-0.9	0.8	-0.8	0.6	0.5	-0.7	-0.5	0.4
Bone: cortical thickness	2.3	3.9	7.4	2.1	-2.3	2.7	-2.3	1.3	0.4	-2.7	-2.0	-0.3
Bone: cortical thickness	0.4	0.5	2.6	0.3	-0.7	0.7	-0.6	-0.5	-0.6	-1.6	-0.1	0.2
Bone: cortical tissue density	0.4	0.7	2.1	0.5	-0.5	1.0	-0.4	0.2	-0.5	-1.0	-1.4	-1.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.4	0.4	-0.4	0.2	0.1	-0.5	-0.4	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.8	0.3	-0.3	0.5	-0.2	0.1	-0.3	-0.5	-0.9	-0.5
Condit. Reinf. active responses	0.0	0.1	0.3	0.1	-0.1	-0.1	0.0	0.2	0.3	0.2	0.1	0.6
Condit. Reinf. inactive responses	0.4	0.6	1.2	-0.4	0.4	-0.8	0.5	-0.0	0.6	1.0	1.1	1.1
Incentive salience index mean	0.2	0.3	0.9	0.5	-0.6	0.4	-0.5	0.3	0.5	-0.4	0.1	1.0
Condit. Reinf. lever presses	0.5	0.7	1.8	0.8	-0.8	0.4	-0.8	1.0	1.2	0.0	0.2	1.3
Condit. Reinf. active minus inactive responses	0.1	0.2	1.0	-0.0	0.2	-0.3	0.3	0.5	0.6	1.0	-0.1	0.3
Condit. Reinf. active-inactive response ratio	0.7	1.1	4.6	-0.5	0.8	-1.2	1.0	0.3	0.9	2.2	0.7	0.8
Condit. Reinf. active responses	0.1	0.2	0.5	0.5	-0.4	0.4	-0.3	0.7	0.6	0.2	-0.5	0.1
Condit. Reinf. inactive responses	0.5	0.7	2.1	0.8	-0.8	1.1	-1.0	0.2	-0.2	-1.4	-0.7	-0.3
Condit. Reinf. lever presses	1.8	2.6	5.3	2.0	-1.7	1.4	-1.7	2.3	2.3	-0.1	-0.6	1.1
Condit. Reinf. lever reinforcers received	0.4	0.5	1.2	0.9	-0.7	0.7	-0.7	1.1	0.9	-0.0	-0.8	0.1
Conditioned reinforcement - actives	0.2	0.8	2.3	0.6	-0.1	0.1	0.1	1.5	1.4	1.4	-0.6	0.1
Conditioned reinforcement - inactives	0.8	2.1	6.8	-1.2	2.0	-1.5	1.5	-0.1	-0.1	2.6	0.1	-1.3
Conditioned locomotion	4.8	7.1	11.7	-3.1	3.3	-3.0	3.4	-1.9	-2.0	3.2	0.7	-2.0
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.1	0.0	-0.0	0.1	-0.0	-0.2	0.1	-0.4	-0.1
Patch foraging indifference point AUC	1.4	3.4	5.5	2.3	-1.8	2.2	-2.0	2.3	1.9	-0.9	-1.8	0.4
Delay disc. indifference point, 0s delay	0.8	0.9	4.2	-0.6	0.4	-0.9	0.2	-0.8	0.1	0.2	2.0	1.4
Delay disc. indifference point, 16s delay	0.3	0.4	0.9	-0.7	0.9	-0.7	0.6	-0.4	-0.3	0.9	0.3	-0.3
Delay disc. indifference point, 2s delay	0.3	0.3	1.6	-0.2	0.3	-0.6	0.1	-0.1	0.5	0.6	1.3	0.5
Delay disc. indifference point, 24s delay	0.1	0.2	0.6	-0.2	0.2	0.1	-0.2	-0.7	-0.8	-0.7	0.1	-0.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.3	-0.4	0.2	-0.3	-0.2	-0.8	-0.4	-0.5	1.1	0.9
Delay disc. indifference point, 8s delay	0.2	0.3	1.2	-0.3	0.0	-0.2	-0.2	-0.7	-0.3	-0.5	1.1	0.7
Indifference point function ln k	3.5	10.4	16.7	-4.1	3.5	-3.7	3.5	-4.1	-3.4	1.7	2.6	-0.9
Indifference point function log k	3.5	10.4	16.7	-4.1	3.5	-3.7	3.5	-4.1	-3.4	1.7	2.6	-0.9
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	-0.1	-0.0	0.1	-0.0	-0.3	-0.5	-0.4	-0.6	-0.3
Patch foraging total patch changes 12 sec	3.8	5.1	7.7	2.7	-2.5	2.7	-2.8	2.4	1.9	-1.9	-1.8	1.0
Patch foraging total patch changes 18 sec	0.5	1.2	1.8	1.3	-0.9	1.2	-1.2	1.3	1.0	-0.6	-1.2	0.6
Patch foraging total patch changes 24 sec	0.8	2.6	4.3	1.9	-1.8	2.1	-2.0	1.6	1.1	-1.5	-1.5	0.3
Patch foraging total patch changes 6 sec	0.6	1.0	1.9	1.1	-1.3	1.1	-1.4	0.7	0.7	-1.1	-0.2	1.0
Patch foraging time to switch 0 sec	0.7	2.5	6.1	1.7	-1.6	0.9	-1.4	1.9	2.5	0.0	0.8	2.2
Patch foraging water rate 0 sec	1.4	5.1	8.9	-2.6	2.8	-1.9	2.4	-2.5	-3.0	1.0	-0.3	-2.5
Patch foraging water rate 12 sec	2.8	11.1	19.7	-4.1	3.7	-3.1	3.5	-4.2	-4.4	1.2	0.8	-3.0
Patch foraging water rate 18 sec	1.8	4.0	7.4	-2.5	2.1	-2.1	2.0	-2.7	-2.6	0.6	1.2	-0.7
Patch foraging water rate 24 sec	3.1	4.4	7.1	-2.6	2.6	-2.1	2.1	-2.6	-2.7	1.0	0.7	-1.6
Patch foraging water rate 6 sec	4.4	6.4	12.6	-3.1	2.7	-2.3	2.6	-3.4	-3.5	0.5	0.8	-1.9
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	-0.6	0.5	-0.5	0.6	-0.6	-0.6	0.2	0.1	0.1
Distance traveled before self-admin	0.6	1.2	3.3	1.3	-0.9	0.8	-1.0	1.7	1.8	0.2	-0.4	0.6
Distance traveled after self-admin	0.4	0.7	1.8	0.8	-0.5	0.9	-0.7	0.8	0.3	-0.4	-1.3	-1.1
Extensor digitorum longus weight	5.5	22.0	34.9	5.6	-5.9	5.1	-5.7	4.6	4.5	-4.0	-1.4	3.7
Bone: elastic displacement	1.3	1.7	4.7	-1.4	1.1	-0.7	1.1	-1.8	-2.2	-0.5	-0.1	-1.5
Bone: elastic work	0.7	0.9	3.7	0.6	-1.0	1.0	-1.1	-0.2	-0.5	-1.9	-0.3	0.3
Bone: endosteal estimation	1.4	3.4	8.5	-1.1	1.3	-2.2	1.2	-0.4	1.0	2.4	2.9	2.4
Bone: endosteal perimeter	1.6	3.9	9.9	-1.1	1.4	-2.4	1.4	0.0	1.4	3.1	2.8	2.2
Epididymis fat weight	1.4	7.1	15.6	-2.8	3.4	-3.5	3.2	-1.5	-0.7	4.0	1.7	-0.2
Delta time in closed arm before/after self-admin	0.7	0.6	1.8	-0.4	-0.4	-0.1	0.3	-1.3	-1.0	-1.4	0.7	0.7
Delta time in open arm before/after self-admin	1.0	1.2	3.2	1.3	-0.5	1.0	-1.0	1.8	1.4	0.4	-1.3	-0.4
Diff in mean of infusions in LGA sessions	0.3	0.6	1.0	0.9	-0.8	1.0	-0.7	0.6	0.4	-0.9	-1.0	0.1
Delay discount exponential model param	0.1	0.2	0.8	-0.0	0.0	0.1	0.4	0.3	-0.1	0.3	-0.9	-0.7
Extinction: sum of active levers before priming	1.5	2.3	3.4	1.8	-1.8	1.5	-1.6	1.7	1.8	-0.9	-0.6	1.3
Active lever presses in extinction session 6	3.7	3.7	6.7	2.4	-2.1	2.0	-1.9	2.6	2.4	-0.7	-1.3	1.0
Bone: final force	2.1	3.4	5.3	2.1	-2.2	1.6	-2.0	2.1	2.3	-0.8	0.0	2.1
Bone: final moment	1.9	3.1	4.8	2.0	-2.1	1.6	-2.0	2.0	2.2	-0.9	-0.0	2.0
Food consumed during 24 hour testing period	0.2	0.4	1.4	0.5	-0.2	0.6	-0.4	0.7	0.2	0.1	-1.0	-1.2
Glucose	2.5	4.0	7.2	-2.2	2.1	-2.7	2.0	-1.8	-0.7	2.1	2.6	0.9
Heart weight	1.6	2.6	8.0	-1.5	1.2	-1.9	1.0	-1.7	-0.5	0.7	2.8	1.9
Delay discount hyperbolic model param	0.2	0.2	1.0	-0.0	0.0	0.2	0.4	0.2	-0.2	0.2	-1.0	-0.9
Intermittent access intake day 1-15 change	0.2	1.0	2.7	-0.7	1.4	-0.8	1.2	0.1	-0.2	1.6	-0.5	-1.2
Intermittent access intake escalation	0.2	0.8	2.7	-0.5	1.2	-0.6	1.0	0.3	0.0	1.6	-0.6	-1.1
Intermittent access intake escalation 2	0.5	0.8	2.5	-0.5	1.1	-0.7	1.0	0.3	0.0	1.6	-0.6	-1.1
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.5	-0.3	0.4	-0.2	0.2	-0.1	-0.2	0.5	-0.2	-0.7
Intermitt. access day 15 inactive lever presses	0.3	1.9	6.3	-1.2	1.6	-1.7	1.8	-0.2	0.1	2.5	0.6	-0.5
Intermitt. access escalation Index	0.9	2.9	4.2	-2.1	2.0	-1.7	1.8	-2.0	-2.0	0.9	0.6	-1.4
Intermittent access day 1 total infusions	1.5	4.5	9.8	-1.8	1.9	-2.8	2.1	-0.7	0.6	3.1	3.0	1.5
Intermittent access day 15 total infusions	2.2	5.4	15.5	-2.2	2.8	-3.0	2.9	-0.7	0.0	3.9	1.8	-0.1
Intermittent access terminal intake (last 3 days)	2.9	5.1	16.2	-1.8	2.5	-2.9	2.4	-0.2	0.8	4.0	2.1	0.6
Intermittent access total infusions	4.0	4.7	12.6	-1.8	2.2	-2.8	2.4	-0.5	0.6	3.6	2.5	1.1
Intermittent access day 1 locomotion	1.5	2.8	5.9	-1.5	1.7	-2.2	1.7	-0.7	0.2	2.4	2.1	0.9
Intermittent access day 15 total locomotion	1.0	4.0	14.1	-1.6	2.5	-2.5	2.4	-0.1	0.5	3.8	1.2	-0.0
Intermittent access total locomotion	5.5	6.6	20.8	-2.2	2.9	-3.3	2.9	-0.4	0.6	4.6	2.3	0.5
Intermittent access standard deviation	0.2	1.2	2.8	-1.1	1.4	-1.3	1.4	-0.5	-0.4	1.7	0.3	-0.8
Left kidney weight	0.2	1.9	4.1	-1.3	1.7	-1.8	1.3	-0.6	0.1	2.0	1.8	0.7
Right kidney weight	0.1	1.0	2.4	-0.9	1.2	-1.3	1.0	-0.4	0.0	1.5	1.0	0.5
Cocaine induced anxiety	0.1	0.2	0.6	0.5	-0.2	0.3	-0.3	0.8	0.7	0.4	-0.3	-0.0
Post-drug Anxiety	0.5	0.5	1.1	0.9	-0.9	0.7	-0.6	1.0	1.0	-0.2	-0.2	0.3
Baseline Anxiety	0.1	0.3	1.2	0.2	-0.6	0.4	-0.3	-0.4	-0.4	-1.1	0.1	0.0
Tail length	0.3	1.6	5.0	1.1	-1.5	1.7	-1.3	0.3	-0.3	-2.2	-1.2	-0.5
Length with tail	1.2	5.5	10.1	2.7	-3.2	2.8	-2.8	1.7	1.4	-2.9	-1.0	1.3
Length without tail	0.8	4.1	7.5	2.2	-2.7	2.3	-2.5	1.4	1.3	-2.5	-0.8	1.4
Times rat made contact with spout	0.5	0.5	1.7	0.6	-0.8	1.0	-0.9	0.1	-0.2	-1.3	-0.6	-0.3
Lifetime Intake	3.0	3.7	8.3	-1.7	1.9	-2.5	2.1	-0.7	0.3	2.9	2.4	1.2
Liver weight, left	0.8	1.4	2.2	-1.4	1.2	-1.5	1.3	-1.4	-0.9	0.7	1.3	0.4
Liver weight, right	2.2	3.9	6.6	-2.4	2.0	-2.3	1.9	-2.6	-1.8	0.8	2.3	0.4
Locomotor activity	1.9	3.0	6.5	-2.2	2.0	-1.6	1.5	-2.5	-2.6	0.2	0.5	-1.1
Locomotor testing distance	1.7	4.1	8.7	-2.5	2.2	-1.8	1.8	-2.9	-2.9	0.1	0.9	-1.0
Locomotor testing rearing	0.9	3.5	6.9	-2.3	2.0	-1.8	1.9	-2.6	-2.5	0.3	1.0	-0.9
Locomotion in novel chamber	3.2	4.3	7.5	-2.4	2.6	-2.6	2.4	-1.5	-1.2	2.7	1.2	-0.8
Locomotion in novel chamber post-restriction	1.0	3.0	5.3	-1.9	2.3	-2.1	2.3	-1.1	-0.9	2.3	0.7	-1.0
Fecal boli incidents, locomotor time 1	0.2	0.6	1.7	0.7	-0.2	0.3	-0.5	1.3	1.3	0.8	-0.5	0.1
Change in fecal boli incidents, locomotor task	0.7	0.7	2.0	-0.8	0.1	-0.6	0.3	-1.2	-0.9	-0.5	1.4	0.8
Time >=10cm from walls, locomotor time 1	1.2	1.5	5.1	-0.3	0.7	-1.2	0.6	0.7	1.4	2.3	1.2	1.4
Bouts of movement, locomotor time 1	2.3	3.0	9.6	1.6	-1.3	2.2	-1.3	1.4	0.1	-1.5	-3.1	-1.7
Total resting periods, locomotor time 1	2.1	2.4	8.1	1.4	-1.1	1.9	-1.1	1.4	0.1	-1.0	-2.8	-1.6
Rest time, locomotor task time 1	0.7	1.2	1.9	-1.2	1.4	-1.1	1.4	-0.9	-1.1	1.1	-0.2	-1.0
Distance moved, locomotor task time 1	0.1	0.3	0.8	0.4	-0.3	0.1	-0.6	0.4	0.8	-0.1	0.8	0.9
Vertical activity count, locomotor time 1	0.1	1.0	1.8	-1.2	1.2	-1.3	1.0	-0.9	-0.5	0.9	1.2	0.2
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.4	0.7	-0.4	0.5	-0.3	1.2	0.9	0.6	-1.1	-0.5
Bouts of movement, locomotor time 2	0.2	0.5	1.3	0.8	-0.7	1.0	-0.6	0.7	0.2	-0.7	-1.1	-0.4
Total resting periods, locomotor time 2	0.1	0.2	0.7	0.5	-0.4	0.6	-0.3	0.5	0.2	-0.3	-0.9	-0.4
Rest time, locomotor task time 2	1.4	2.4	4.0	-1.9	1.8	-2.0	1.8	-1.5	-1.0	1.7	1.2	0.2
Distance moved, locomotor task time 2	1.1	1.4	2.4	1.4	-1.3	1.5	-1.4	1.1	0.6	-1.2	-1.3	-0.3
Vertical activity count, locomotor time 2	0.1	0.3	1.0	-0.3	0.1	0.2	0.0	-0.7	-1.0	-0.8	-0.4	-0.7
Light reinforcement 1	0.0	0.2	0.7	-0.2	0.1	0.0	0.4	-0.3	-0.6	-0.1	-0.8	-0.8
Light reinforcement 2	0.5	1.1	4.6	-0.7	0.9	-1.1	1.4	0.3	0.5	2.2	-0.0	-0.4
Bone: marrow area	1.4	3.5	9.1	-1.3	1.3	-2.3	1.3	-0.6	0.9	2.4	3.0	2.4
Bone: maximum diameter	0.5	1.0	3.5	0.9	-0.6	0.3	-0.6	1.5	1.9	0.9	0.2	0.9
Bone: maximum force	3.0	5.9	11.9	2.6	-2.6	1.6	-2.4	2.8	3.4	-0.3	0.6	3.4
Bone: maximum moment	2.8	5.3	10.6	2.5	-2.4	1.5	-2.3	2.6	3.3	-0.4	0.5	3.2
Mean time between licks in bursts	0.1	0.6	2.8	0.1	-0.6	0.5	-0.6	-0.8	-0.9	-1.7	0.0	0.1
Mean num. licks in bursts	0.1	0.3	1.0	-0.6	0.5	-0.3	0.4	-0.9	-1.0	-0.3	0.0	-0.4
Cd content in liver	0.7	0.7	2.8	-0.6	1.2	-0.9	1.0	0.2	0.2	1.7	-0.1	-0.5
Co content in liver	2.0	2.3	6.5	-1.4	1.2	-0.5	1.1	-1.9	-2.6	-0.7	-0.6	-2.2
Cu content in liver	0.1	0.1	0.5	-0.0	0.1	0.1	0.1	-0.0	-0.2	-0.0	-0.5	-0.7
Fe content in liver	0.2	0.3	1.0	0.4	-0.3	0.2	-0.4	0.4	0.8	-0.1	0.5	1.0
K content in liver	0.6	0.5	2.1	0.5	-0.6	0.3	-0.7	0.1	0.6	-0.7	0.8	1.4
Mg content in liver	0.5	0.5	1.1	-0.8	0.6	-0.8	0.5	-1.0	-0.7	0.0	1.0	0.5
Mn content in liver	2.8	3.2	5.1	2.2	-2.0	1.9	-1.9	2.3	2.0	-0.8	-1.2	1.0
Na content in liver	0.3	0.3	0.6	0.7	-0.8	0.7	-0.6	0.5	0.4	-0.6	-0.3	0.4
Rb content in liver	2.2	2.6	4.3	-2.0	1.7	-1.8	1.9	-2.1	-1.6	0.8	1.4	0.0
Se content in liver	0.2	0.3	1.2	0.1	0.4	-0.2	0.2	0.7	0.7	1.1	-0.3	-0.4
Sr content in liver	2.8	2.4	3.8	1.9	-1.7	2.0	-1.7	1.7	1.1	-1.3	-1.6	-0.3
Zn content in liver	0.4	0.5	0.8	0.7	-0.7	0.9	-0.8	0.5	0.2	-0.9	-0.7	-0.6
Bone: minimum diameter	1.2	2.3	5.4	-1.0	1.1	-1.9	1.1	-0.3	0.8	2.1	2.3	1.7
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.5	0.5	-0.6	0.5	-0.4	-0.3	0.4	0.5	0.6
Time in novel zone, hab. session 1	0.3	0.4	1.0	-0.7	0.4	-0.5	0.5	-1.0	-0.9	-0.3	0.6	-0.6
Total zone transitions, hab. session 1	0.3	0.5	1.0	0.8	-1.0	0.7	-0.7	0.8	0.7	-0.5	-0.3	0.4
Total locomotion distance, hab. session 1	0.5	0.7	1.7	-0.8	0.6	-1.1	0.8	-0.5	0.1	1.0	1.3	0.9
Locomotion velocity, hab. session 1	0.1	0.2	0.6	-0.2	0.1	-0.5	0.3	-0.1	0.2	0.5	0.7	0.7
Time in familiar zone, hab. session 2	0.4	0.4	1.6	-0.3	0.1	0.2	-0.2	-1.0	-1.1	-1.3	0.2	-0.0
Time in novel zone, hab. session 2	0.2	0.2	0.6	0.3	-0.2	-0.0	-0.1	0.7	0.8	0.6	0.0	0.1
Total zone transitions, hab. session 2	1.0	1.2	3.6	1.0	-1.4	0.6	-1.0	0.8	1.3	-0.6	0.8	1.9
Total locomotion distance, hab. session 2	0.5	0.7	2.7	-0.4	-0.1	-0.7	0.3	-0.5	0.2	0.3	1.6	1.7
Locomotion velocity, hab. session 2	0.6	0.8	2.8	-0.5	0.1	-0.9	0.5	-0.4	0.3	0.7	1.6	1.7
Novel to familiar place preference ratio	1.4	1.9	4.6	1.7	-1.1	1.2	-1.3	2.1	2.0	0.2	-1.0	0.3
Novelty place preference	0.9	1.1	3.0	1.2	-0.8	0.9	-0.9	1.7	1.6	0.4	-0.9	0.0
Time in novel zone, NPP test	0.7	0.8	2.2	1.1	-0.6	0.7	-0.8	1.5	1.4	0.4	-0.7	0.1
Total zone transitions, NPP test	1.6	2.3	4.0	1.8	-2.0	1.4	-1.7	1.6	1.8	-0.9	-0.0	1.5
Total locomotion distance, NPP test	0.3	0.4	1.6	-0.2	-0.3	-0.5	0.2	-0.2	0.4	0.2	1.2	1.3
Locomotion velocity, NPP test	0.1	0.2	1.0	-0.0	-0.4	-0.2	0.1	-0.0	0.4	0.1	0.8	1.0
Intraocular pressure	0.9	1.4	5.1	-0.4	1.2	-0.2	0.9	0.2	-0.6	1.1	-1.9	-2.3
Delta distance traveled before/after self-admin	0.8	0.9	2.9	-0.8	0.5	-0.1	0.4	-1.3	-1.7	-0.8	-0.4	-1.3
Delta ambulatory time before/after self-admin	0.4	0.6	2.0	-0.6	0.2	-0.1	0.3	-1.1	-1.4	-0.9	-0.1	-1.1
Parametrial fat weight	2.3	5.5	10.5	-2.5	2.9	-3.1	2.6	-1.5	-0.6	3.2	2.1	0.1
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.6	0.6	-0.5	0.7	-0.5	-0.6	0.4	0.0	-0.7
Pavlov. Cond. magazine entry latency	0.4	0.6	1.4	0.8	-0.6	0.5	-0.8	1.0	1.2	0.1	0.0	0.9
Pavlov. Cond. change in total contacts	0.5	0.5	1.4	0.7	-0.4	0.4	-0.4	1.2	1.1	0.6	-0.6	0.0
Pavlov. Cond. index score	0.4	0.5	0.9	0.8	-0.6	0.8	-0.8	0.9	0.7	-0.2	-0.7	0.0
Pavlov. Cond. latency score	0.2	0.2	0.4	0.6	-0.4	0.5	-0.6	0.6	0.6	-0.2	-0.3	0.3
Pavlov. Cond. lever contacts	0.1	0.2	0.6	0.3	-0.3	0.2	-0.4	0.2	0.4	-0.2	0.2	0.8
Pavlov. Cond. magazine entry number	0.6	0.8	1.5	-1.0	0.7	-1.0	0.9	-1.2	-0.8	0.2	1.2	0.5
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.7	-0.6	0.9	-0.3	0.8	-0.3	-0.8	0.6	-1.1	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.3	1.0	-0.8	0.9	-1.0	1.1	1.0	-0.3	-0.7	0.2
Pavlov. Cond. response bias	0.4	0.5	0.9	0.8	-0.6	0.8	-0.7	1.0	0.7	-0.2	-0.8	-0.1
Pavlov. Cond. lever latency	0.8	1.1	2.5	-1.2	0.9	-0.8	1.1	-1.6	-1.6	-0.2	0.5	-0.6
Pavlov. Cond. magazine entry latency	3.4	4.8	7.4	2.7	-2.5	2.5	-2.6	2.6	2.3	-1.5	-1.3	1.2
Pavlov. Cond. change in total contacts	1.2	3.0	7.3	2.1	-1.6	1.5	-1.5	2.7	2.5	0.3	-1.3	0.5
Pavlov. Cond. index score	2.3	3.7	6.9	2.3	-2.0	1.8	-2.1	2.6	2.5	-0.4	-1.1	1.1
Pavlov. Cond. latency score	2.0	3.2	6.3	2.1	-1.8	1.6	-1.9	2.5	2.5	-0.2	-0.9	1.2
Pavlov. Cond. lever contacts	0.8	1.1	2.5	1.3	-1.0	0.9	-1.1	1.6	1.5	0.1	-0.6	0.6
Pavlov. Cond. magazine entry number	6.1	8.0	12.2	-3.5	3.2	-3.1	3.2	-3.5	-3.1	1.5	1.9	-1.3
Pavlov. Cond. intertrial magazine entries	0.4	0.9	1.6	-1.1	1.3	-1.1	1.2	-0.9	-0.9	0.9	0.4	-0.7
Pavlov. Cond. lever-magazine prob. diff.	2.8	4.3	7.8	2.5	-2.2	2.1	-2.3	2.8	2.6	-0.6	-1.3	1.1
Pavlov. Cond. response bias	2.2	3.0	5.4	2.1	-1.8	1.7	-2.0	2.3	2.2	-0.5	-1.0	1.0
Time in closed arm before self-admin	0.2	0.3	1.7	-0.1	0.6	-0.5	0.2	0.5	0.6	1.3	0.2	0.2
Time in closed arm after self-admin	0.6	0.7	1.3	-1.0	0.6	-0.9	0.9	-1.2	-0.9	0.2	0.9	0.2
Time in open arm before self-admin	1.5	1.8	5.4	-1.3	0.4	-0.6	0.7	-2.3	-2.2	-1.5	0.9	-0.4
Time in open arm after self-admin	0.3	0.3	0.9	0.4	-0.4	0.7	-0.6	-0.0	-0.3	-1.0	-0.6	-0.5
Bone: periosteal estimation	0.6	1.4	4.3	0.2	0.0	-0.7	0.0	0.8	1.7	1.4	1.6	2.1
Bone: periosteal perimeter	0.5	1.0	2.7	0.5	-0.4	-0.2	-0.4	1.0	1.6	1.0	1.0	1.5
Bone: post-yield work	2.5	4.3	13.2	1.0	-0.8	-0.5	-0.5	2.0	3.3	2.1	2.1	3.6
Progressive ratio test 1 active lever presses	0.3	0.6	1.9	-0.4	0.6	-0.8	0.7	0.2	0.5	1.4	0.9	0.4
Progressive ratio test 1 breakpoint	0.3	0.5	1.9	-0.3	0.5	-0.8	0.6	0.3	0.7	1.4	0.9	0.4
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.4	0.0	0.3	-0.1	-0.1	0.4	0.3	0.6	-0.3	-0.3
Progressive ratio test 2 active lever presses	1.6	2.3	7.8	-1.3	1.8	-1.9	1.9	-0.1	0.3	2.8	1.0	-0.1
Progressive ratio test 2 breakpoint	1.8	2.3	7.7	-1.3	1.8	-1.8	1.9	-0.1	0.2	2.8	1.0	-0.1
Progressive ratio test 2 inactive lever presses	2.0	6.4	15.4	-2.6	3.3	-3.1	3.2	-1.1	-0.9	3.9	0.9	-1.3
Incentive Sensitization - Responses	0.2	0.4	1.2	0.2	0.2	-0.3	0.2	0.7	1.0	1.1	0.4	0.8
Incentive Sensitization - Breakpoint	0.2	0.4	1.6	-0.0	0.4	-0.5	0.4	0.5	0.9	1.3	0.4	0.7
Sum of active levers in priming session hrs 5-6	2.9	2.7	7.2	1.8	-1.1	1.8	-1.1	2.4	1.5	0.1	-2.7	-1.0
Progressive ratio	0.6	1.8	4.6	1.3	-1.2	0.5	-1.1	1.5	2.1	0.2	0.8	2.1
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.0	-0.1	0.1	-0.2	-0.3	-0.2	-0.5	0.4	0.2
Seeking ratio, punishment vs. effort	1.2	2.6	6.9	-1.7	1.5	-0.9	1.3	-2.3	-2.6	-0.5	0.1	-1.7
Retroperitoneal fat weight	6.5	29.2	44.6	-6.6	6.7	-6.7	6.4	-5.4	-4.3	5.2	3.7	-1.2
Reaction time number correct	0.1	0.3	0.6	0.6	-0.6	0.8	-0.7	0.4	0.1	-0.7	-0.7	-0.2
Reaction time mean minus median	0.8	5.0	8.7	2.7	-2.5	2.2	-2.3	2.9	2.8	-0.7	-1.2	1.7
Reaction time mean minus median AUC	0.4	2.6	4.1	2.0	-1.8	1.8	-1.7	2.0	1.7	-0.8	-1.3	0.9
Reaction time num false alarms	0.8	1.4	4.4	-1.3	0.7	-0.7	0.9	-2.0	-2.1	-0.9	0.5	-0.4
Reaction time num false alarms AUC	0.3	0.8	2.6	-0.6	0.1	0.0	0.2	-1.4	-1.6	-1.4	0.1	-0.1
Reaction time trials correct on left	0.1	0.3	0.6	0.6	-0.6	0.8	-0.7	0.4	0.1	-0.7	-0.7	-0.2
Reaction time trials on left	0.1	0.4	0.8	0.7	-0.7	0.9	-0.8	0.5	0.1	-0.8	-0.8	-0.2
Reaction time mean	0.2	0.3	1.0	0.5	-0.4	0.3	-0.2	1.0	0.9	0.6	-0.5	0.1
Reaction time mean AUC	0.1	0.3	1.0	0.5	-0.3	0.2	-0.2	1.0	0.9	0.7	-0.5	0.1
Median of all reaction times	0.1	0.2	0.9	-0.1	0.2	-0.4	0.4	0.4	0.4	1.0	-0.1	-0.3
Reaction time omissions	1.1	1.8	3.0	1.6	-1.7	1.6	-1.5	1.6	1.1	-0.9	-1.2	0.4
Reaction time false alarm rate	0.7	1.0	2.8	-1.1	0.6	-0.7	0.7	-1.7	-1.6	-0.6	0.7	0.1
Reaction time premature initiation rate	1.4	2.1	6.8	1.3	-2.0	1.7	-1.7	0.2	0.2	-2.6	-0.1	0.9
Reaction time premature initiations	1.2	3.6	9.8	1.9	-2.5	2.4	-2.3	0.7	0.3	-3.1	-1.0	0.5
Std. dev. reaction times	0.5	1.5	3.1	1.5	-1.4	1.3	-1.0	1.8	1.5	-0.2	-1.1	0.7
Reaction time trials completed	0.1	0.4	0.8	0.7	-0.7	0.9	-0.8	0.5	0.1	-0.8	-0.8	-0.2
Reaction time trials AUC	0.1	0.2	0.5	0.4	-0.5	0.6	-0.6	0.2	-0.1	-0.7	-0.5	-0.1
Run reversals in cocaine runway, females	0.8	0.9	3.2	-0.1	-0.5	-0.2	-0.4	-0.8	-0.1	-0.9	1.8	1.7
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.5	0.7	-0.4	0.2	-0.5	-0.5	0.1	0.2	-0.4
Latency to leave start box in cocaine runway	0.4	0.5	1.5	-0.4	0.3	-0.8	0.7	-0.2	0.4	0.8	1.2	1.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.1	0.1	-0.2	0.4	0.0	0.2	0.3	0.3	0.5
Latency to leave start box in cocaine runway, M	0.5	0.5	1.9	-0.2	0.0	-0.6	0.3	-0.1	0.5	0.5	1.4	1.2
Std. dev. time between licks in bursts	0.4	0.7	2.1	-0.7	0.1	-0.2	0.1	-1.4	-1.4	-1.1	0.5	-0.2
Total sessions with >9 infusions	0.5	0.6	1.9	-0.2	0.1	-0.7	0.4	0.1	0.7	0.9	1.3	1.4
Short access day 1 total inactive lever presses	1.5	3.1	5.0	-2.1	2.0	-2.2	2.2	-1.7	-1.3	1.7	1.3	-0.3
Short access day 10 total inactive lever presses	0.1	0.8	1.9	-1.1	0.9	-0.8	0.9	-1.3	-1.4	0.0	0.2	-0.7
Short access day 1 total infusions	1.2	2.4	4.2	-1.7	1.5	-2.1	1.8	-1.2	-0.4	1.8	1.9	0.8
Short access day 10 total infusions	1.4	2.2	5.7	-0.8	0.8	-1.7	1.0	-0.0	1.1	2.1	2.4	2.0
Short access total infusions	1.4	2.0	5.8	-1.0	0.8	-1.7	1.1	-0.5	0.5	1.6	2.4	1.8
Short access day 1 locomotion	0.9	1.5	2.6	-1.3	1.5	-1.6	1.4	-0.8	-0.4	1.6	1.1	0.3
Short access day 10 total locomotion	0.3	1.1	3.7	-0.8	1.2	-1.3	0.9	-0.0	0.5	1.9	1.1	0.3
Short access total locomotion	1.1	1.7	4.5	-1.2	1.4	-1.7	1.3	-0.4	0.2	2.1	1.5	0.5
One hour access (0.3 mA shock)	4.4	5.3	9.4	-2.6	3.0	-2.9	2.7	-1.5	-1.1	3.1	1.5	-0.7
Compulsive drug intake	1.6	2.3	9.4	0.9	-1.5	1.8	-1.5	-0.4	-1.0	-3.1	-1.2	-0.4
One hour access (shock baseline)	2.4	6.3	17.4	-2.5	3.2	-3.2	2.9	-0.9	-0.3	4.2	1.7	-0.7
Social response proportion	0.6	0.7	1.2	1.1	-0.9	1.0	-1.0	1.1	1.0	-0.4	-0.6	0.3
Social responses	0.4	0.5	1.0	0.7	-0.6	1.0	-0.9	0.5	0.1	-0.9	-1.0	-0.1
Social time	0.2	0.4	0.8	0.6	-0.7	0.8	-0.7	0.3	0.1	-0.9	-0.7	0.1
Soleus weight	3.2	9.6	14.5	-3.8	3.6	-3.6	3.8	-3.3	-3.0	2.5	1.6	-1.4
Bone: stiffness	2.3	4.2	8.5	2.3	-2.2	1.5	-2.0	2.6	2.9	-0.1	-0.0	2.5
Tibialis anterior weight	7.9	27.1	40.5	6.3	-6.4	6.1	-6.3	5.4	4.7	-4.4	-2.9	2.5
Time to tail flick, vehicle, before self-admin	0.6	0.7	2.0	0.6	-0.7	0.0	-0.3	0.8	1.3	0.4	0.9	1.4
Time to tail flick, vehicle, after self-admin	0.7	1.5	5.7	0.9	-0.8	0.4	-1.3	0.5	1.3	-0.7	1.4	2.4
Time to tail flick, test, before self-admin	1.9	2.2	3.9	-1.7	1.6	-1.9	1.1	-1.5	-0.9	1.1	2.0	1.0
Time to tail flick, test, after self-admin	0.3	0.3	0.8	0.7	-0.2	0.4	-0.5	0.9	0.9	0.2	-0.5	0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.1	0.5	-0.4	0.5	-0.9	0.1	0.3	-0.9	0.4	1.0
Delta time to tail flick, test, before/after SA	2.5	3.1	7.4	1.9	-1.6	2.2	-1.3	1.9	0.9	-1.0	-2.7	-1.6
Tibia length	1.4	4.0	9.5	2.4	-1.7	1.9	-1.8	3.1	2.7	0.2	-1.7	0.4
Ambulatory time before self-admin	0.4	1.3	3.4	1.3	-0.7	0.8	-1.0	1.8	1.9	0.5	-0.7	0.5
Ambulatory time after self-admin	0.2	0.3	1.3	-0.1	0.5	-0.2	0.2	0.3	0.1	0.7	-0.4	-1.1
Bone: tissue strength	0.0	0.0	0.1	-0.0	0.0	-0.0	0.2	0.1	0.0	0.2	-0.3	0.0
Total heroin consumption	4.8	5.6	8.6	2.9	-2.7	2.9	-2.8	2.5	1.9	-2.1	-2.2	0.6
Bone: trabecular number	0.9	1.6	4.7	1.4	-1.1	0.7	-1.2	1.7	2.2	0.3	0.4	1.4
Bone: trabecular spacing	0.7	1.0	3.4	-1.1	0.8	-0.5	0.9	-1.5	-1.8	-0.5	-0.3	-0.6
Bone: trabecular thickness	0.4	0.5	1.1	-0.7	0.7	-1.0	0.8	-0.3	0.0	1.1	0.8	0.1
Bone: trabecular tissue density	2.3	4.0	7.0	-2.3	2.6	-2.0	2.5	-1.8	-2.0	1.8	0.2	-1.7
Water consumed over 24 hours	0.7	1.4	2.6	1.2	-1.3	1.6	-1.3	0.8	0.1	-1.6	-1.3	-0.7
Number of responses in last shaping day	0.1	0.2	0.7	-0.3	0.1	0.1	0.1	-0.5	-0.8	-0.6	-0.5	-0.2