Tmprss12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr7_131438339_131442167	0.04	0.04	5.7e-03	0	0	-0	0	2.9e-01	8.8e-02	3.8e-01	8.1e-02
2	BLA	alternative TSS	XM_039080380.1	0.06	0.05	8.9e-03	0.01	0.03	0.02	0.02	5.4e-02	9.6e-03	2.5e-02	4.0e-02
3	Adipose	gene expression	Tmprss12	0.06	0.04	6.2e-09	0.07	0.06	0.05	0.05	2.3e-08	1.0e-06	2.6e-06	1.6e-06
4	NAcc	gene expression	Tmprss12	0.04	0.03	2.8e-06	0.05	0.05	0.04	0.04	2.2e-06	2.8e-06	6.4e-06	6.0e-06
5	Liver	gene expression	Tmprss12	0.03	0.02	1.2e-03	0.01	0.01	0.01	0.01	3.7e-02	9.3e-03	2.3e-02	2.2e-02
6	RMTg	gene expression	Tmprss12	0.26	0.17	1.9e-03	0.03	0.05	0.06	0.07	6.2e-02	2.2e-02	8.9e-03	6.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	5.6	9.3	12.9	3.4	3.6	-3.4	-3.1	2.9	1.3
Area under the delay curve	0.9	1.0	1.1	1.1	1.0	-1.0	-1.0	1.0	0.9
BMI with tail	4.4	14.1	17.4	3.6	3.5	-3.6	-4.2	4.0	3.6
BMI without tail	0.4	0.8	2.1	0.6	1.1	-0.6	-1.4	0.8	0.2
Body weight	4.4	18.6	24.8	4.3	4.5	-4.3	-5.0	4.3	3.2
Weight adjusted by age	0.4	0.5	1.6	0.4	-0.0	-0.4	-0.5	0.9	1.3
Bone surface	7.9	14.0	18.9	4.1	4.3	-4.1	-3.8	3.6	2.0
Bone volume	7.3	12.4	16.3	3.9	4.0	-3.9	-3.6	3.4	1.8
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.2	0.4	-0.2	-0.2	-0.0	-0.3
Number of licking bursts	0.9	1.0	1.7	-1.2	-1.3	1.2	0.7	-0.9	-0.2
Context. condit. distance diff. score	0.3	0.3	0.7	0.4	0.8	-0.4	-0.8	0.3	0.1
Locomotion velocity, session 1	3.8	4.1	5.2	-2.1	-2.1	2.1	2.3	-2.1	-1.3
Locomotion distance, session 1	2.7	3.4	4.6	-1.9	-2.1	1.9	2.1	-1.7	-1.0
Locomotion velocity, session 2	0.3	0.4	0.5	-0.6	-0.6	0.6	0.7	-0.7	-0.6
Locomotion distance, session 2	3.0	4.2	5.7	-2.1	-2.3	2.1	2.4	-1.9	-1.4
Locomotion velocity, session 3	4.7	5.5	6.6	-2.3	-2.0	2.3	2.4	-2.6	-2.4
Locomotion distance, session 3	3.7	4.0	7.9	-1.8	-1.2	1.8	2.0	-2.2	-2.8
Stereotopy head waving bouts, day 3	0.3	0.4	1.6	0.1	-0.6	-0.1	0.1	0.4	1.3
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.2	-0.5	0.2	0.4	-0.3	0.3
Locomotion velocity, session 7	3.6	3.9	6.0	-1.8	-1.4	1.8	2.1	-2.2	-2.5
Locomotion distance, session 7	4.5	5.7	7.6	-2.3	-1.8	2.3	2.3	-2.7	-2.8
Stereotopy head waving bouts, day 7	1.0	1.1	2.8	0.9	0.2	-0.9	-0.8	1.3	1.7
Stereotopy head waving duration, day 7	1.5	1.9	4.0	1.2	0.6	-1.2	-1.2	1.6	2.0
Locomotion velocity, session 8	0.4	0.5	0.6	-0.7	-0.8	0.7	0.7	-0.7	-0.4
Locomotion distance, session 8	1.1	1.6	1.8	-1.3	-1.1	1.3	1.2	-1.3	-1.2
Degree of sensitization distance	0.1	0.1	0.7	-0.0	-0.2	0.0	-0.2	0.2	0.9
Degree of sensitization stereotypy	1.2	1.4	3.1	1.0	0.4	-1.0	-1.0	1.4	1.8
Conditioned locomotion	0.1	0.1	0.2	-0.1	-0.0	0.1	0.4	-0.3	-0.5
Cocaine response after cond. corrected	0.0	0.0	0.2	0.1	-0.3	-0.1	0.1	0.1	0.4
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.4	-0.6	0.4	0.5	-0.4	-0.3
Cocaine response before conditioning	1.8	2.2	2.9	-1.5	-1.0	1.5	1.4	-1.7	-1.7
Saline control response	0.1	0.2	0.6	-0.1	0.4	0.1	0.1	-0.3	-0.8
Bone: connectivity density	2.8	4.4	6.7	2.4	2.6	-2.4	-2.1	1.9	0.9
Bone: cortical apparent density	0.4	0.5	1.3	-0.5	-1.1	0.5	1.0	-0.2	0.5
Bone: cortical area	4.8	7.3	9.7	2.9	3.1	-2.9	-2.9	2.6	1.4
Bone: cortical porosity	0.2	0.2	0.5	0.2	0.7	-0.2	-0.2	-0.1	-0.7
Bone: cortical porosity	0.2	0.2	0.8	-0.0	0.4	0.0	0.2	-0.4	-0.9
Bone: cortical thickness	1.3	2.1	2.9	1.5	1.7	-1.5	-1.6	1.4	0.7
Bone: cortical thickness	0.4	0.4	1.0	-0.6	-0.2	0.6	0.4	-0.7	-1.0
Bone: cortical tissue density	0.5	0.6	1.5	-0.6	-1.2	0.6	1.2	-0.4	0.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.3	-0.2	0.3	0.2	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.3	0.6	-0.3	-0.3	0.2	-0.0
Condit. Reinf. active responses	0.5	0.6	1.0	-1.0	-1.0	1.0	0.7	-0.6	0.0
Condit. Reinf. inactive responses	2.2	2.6	4.8	-1.8	-2.2	1.8	1.6	-1.4	-0.4
Incentive salience index mean	0.1	0.1	0.5	-0.0	0.0	0.0	-0.2	0.4	0.7
Condit. Reinf. lever presses	0.8	1.1	2.8	0.8	0.5	-0.8	-0.9	1.2	1.7
Condit. Reinf. active minus inactive responses	1.2	1.5	1.8	1.2	1.0	-1.2	-1.3	1.3	1.3
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.3	1.0	0.9	-1.0	-1.1	1.1	0.9
Condit. Reinf. active responses	0.2	0.2	0.4	0.4	0.3	-0.4	-0.5	0.7	0.6
Condit. Reinf. inactive responses	0.6	0.8	1.0	-1.0	-1.0	1.0	1.0	-0.7	-0.5
Condit. Reinf. lever presses	0.1	0.1	0.6	0.0	0.3	-0.0	-0.0	-0.3	-0.8
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.1	0.1	0.1
Conditioned reinforcement - actives	1.0	1.0	1.4	-1.0	-1.2	1.0	1.1	-1.0	-0.6
Conditioned reinforcement - inactives	1.7	1.9	2.1	-1.4	-1.3	1.4	1.3	-1.4	-1.5
Conditioned locomotion	0.1	0.2	0.4	-0.4	-0.3	0.4	0.4	-0.6	-0.4
Patch foraging indifference point 0 sec	5.7	9.1	11.0	-3.3	-2.7	3.3	3.2	-3.0	-2.6
Patch foraging indifference point AUC	0.2	0.2	0.6	-0.3	-0.8	0.3	0.5	-0.1	0.4
Delay disc. indifference point, 0s delay	1.8	2.0	2.6	1.6	1.4	-1.6	-1.4	1.3	0.9
Delay disc. indifference point, 16s delay	0.7	0.7	0.9	0.8	1.0	-0.9	-0.9	0.8	0.6
Delay disc. indifference point, 2s delay	2.5	2.8	5.8	1.5	0.8	-1.4	-1.5	2.0	2.4
Delay disc. indifference point, 24s delay	0.6	0.6	0.9	0.7	0.7	-0.7	-0.6	0.8	1.0
Delay disc. indifference point, 4s delay	1.1	1.1	1.5	1.2	1.0	-1.2	-1.0	1.1	0.8
Delay disc. indifference point, 8s delay	1.0	1.1	1.9	1.1	1.4	-1.0	-1.2	0.9	0.4
Indifference point function ln k	3.9	5.5	7.4	2.4	2.7	-2.4	-2.5	2.3	1.6
Indifference point function log k	3.9	5.5	7.4	2.4	2.7	-2.4	-2.5	2.3	1.6
Patch foraging total patch changes 0 sec	5.4	8.7	10.2	-3.2	-2.5	3.2	3.1	-3.0	-2.7
Patch foraging total patch changes 12 sec	5.2	6.7	8.1	-2.8	-2.7	2.8	2.7	-2.5	-1.8
Patch foraging total patch changes 18 sec	6.6	8.5	9.8	-3.1	-2.9	3.1	3.1	-2.9	-2.4
Patch foraging total patch changes 24 sec	4.0	4.9	5.8	-2.4	-2.1	2.4	2.2	-2.2	-1.9
Patch foraging total patch changes 6 sec	6.2	9.1	11.2	-3.2	-3.0	3.2	3.3	-3.0	-2.3
Patch foraging time to switch 0 sec	1.9	3.0	3.9	-1.9	-2.0	1.9	1.7	-1.6	-1.2
Patch foraging water rate 0 sec	2.9	4.6	6.1	2.2	2.5	-2.2	-2.4	1.9	1.4
Patch foraging water rate 12 sec	2.1	3.2	4.7	2.0	2.2	-2.0	-1.8	1.6	0.8
Patch foraging water rate 18 sec	0.3	0.3	0.5	0.7	0.7	-0.7	-0.5	0.5	0.3
Patch foraging water rate 24 sec	3.8	5.3	6.9	2.6	2.4	-2.6	-2.1	2.2	1.7
Patch foraging water rate 6 sec	4.7	6.9	9.3	2.8	3.0	-2.8	-2.8	2.4	1.5
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.0	0.9	0.9	-0.9	-0.9	1.0	1.0
Distance traveled before self-admin	2.1	2.2	2.6	-1.6	-1.6	1.6	1.5	-1.5	-1.1
Distance traveled after self-admin	0.7	0.8	1.2	-0.7	-0.6	0.7	0.8	-1.1	-1.1
Extensor digitorum longus weight	5.2	20.5	27.9	4.3	3.3	-4.3	-4.5	5.2	5.3
Bone: elastic displacement	7.1	8.1	10.4	-2.7	-2.6	2.7	3.2	-3.2	-2.6
Bone: elastic work	0.2	0.3	0.8	-0.0	0.1	0.0	0.6	-0.7	-0.9
Bone: endosteal estimation	5.9	12.8	18.1	3.9	4.3	-3.9	-3.7	3.4	1.7
Bone: endosteal perimeter	5.8	12.0	15.2	3.7	3.9	-3.7	-3.8	3.4	1.9
Epididymis fat weight	0.3	0.7	2.7	0.0	1.0	-0.0	-0.4	-0.6	-1.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.2	0.4	-0.2	-0.3	0.2	0.0
Delta time in open arm before/after self-admin	3.8	3.6	5.9	-1.8	-1.3	1.8	1.7	-2.2	-2.4
Diff in mean of infusions in LGA sessions	1.5	1.6	2.3	1.0	1.1	-1.0	-1.5	1.5	1.4
Delay discount exponential model param	1.0	1.0	1.2	-1.1	-0.9	1.0	1.0	-1.0	-0.9
Extinction: sum of active levers before priming	1.1	1.1	1.9	0.8	0.8	-0.8	-1.2	1.2	1.4
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3	0.1	-0.1
Bone: final force	8.8	14.2	20.1	4.1	4.5	-4.1	-4.0	3.5	1.8
Bone: final moment	9.8	16.0	23.4	4.4	4.8	-4.4	-4.2	3.6	1.8
Food consumed during 24 hour testing period	1.4	1.7	3.4	1.3	1.8	-1.3	-1.5	1.0	0.5
Glucose	0.2	0.2	0.5	-0.7	-0.5	0.7	0.3	-0.4	-0.3
Heart weight	0.1	0.1	0.3	0.2	0.6	-0.2	-0.2	0.2	-0.4
Delay discount hyperbolic model param	1.1	1.2	1.4	-1.1	-0.9	1.1	1.1	-1.2	-1.1
Intermittent access intake day 1-15 change	0.4	0.4	1.6	-0.3	-0.0	0.3	0.5	-0.8	-1.3
Intermittent access intake escalation	0.4	0.4	1.6	0.0	0.4	-0.0	0.2	-0.6	-1.3
Intermittent access intake escalation 2	0.3	0.3	1.6	-0.2	0.1	0.2	0.2	-0.6	-1.2
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.8	-0.5	-0.4	0.5	0.5	-0.7	-0.9
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.7	-0.2	-0.1	0.2	0.5	-0.6	-0.8
Intermitt. access escalation Index	0.8	0.7	1.6	-0.9	-1.3	0.9	0.8	-0.4	0.5
Intermittent access day 1 total infusions	1.3	1.5	1.7	-1.2	-1.1	1.2	1.3	-1.3	-1.2
Intermittent access day 15 total infusions	2.0	2.2	3.6	-1.3	-1.1	1.3	1.5	-1.7	-1.9
Intermittent access terminal intake (last 3 days)	1.8	2.0	2.8	-1.3	-1.1	1.3	1.5	-1.6	-1.7
Intermittent access total infusions	1.7	1.9	2.7	-1.3	-1.1	1.3	1.4	-1.6	-1.6
Intermittent access day 1 locomotion	1.8	1.9	2.5	-1.3	-1.0	1.3	1.4	-1.6	-1.6
Intermittent access day 15 total locomotion	1.6	1.7	3.9	-1.1	-0.6	1.1	1.1	-1.5	-2.0
Intermittent access total locomotion	4.1	4.6	5.7	-2.1	-1.7	2.1	2.1	-2.4	-2.4
Intermittent access standard deviation	0.4	0.4	1.7	0.1	0.4	-0.1	0.2	-0.5	-1.3
Left kidney weight	0.9	2.5	3.8	1.6	1.9	-1.6	-1.8	1.5	0.6
Right kidney weight	2.0	5.5	7.0	2.3	2.4	-2.3	-2.6	2.5	1.8
Cocaine induced anxiety	0.7	0.8	1.5	0.9	1.2	-0.9	-1.0	0.6	-0.1
Post-drug Anxiety	4.2	4.7	6.4	2.3	2.5	-2.3	-2.3	2.1	1.1
Baseline Anxiety	0.7	0.8	0.9	0.9	0.8	-0.9	-0.8	0.9	1.0
Tail length	0.2	0.5	2.5	-0.2	0.5	0.2	-0.3	-0.5	-1.6
Length with tail	1.3	4.8	7.2	2.3	2.7	-2.3	-2.6	2.0	0.7
Length without tail	3.9	8.5	9.6	3.1	3.0	-3.1	-3.1	3.0	2.2
Times rat made contact with spout	0.0	0.0	0.1	-0.1	0.2	0.1	-0.2	-0.1	-0.3
Lifetime Intake	2.6	3.0	4.2	-1.6	-1.3	1.6	1.7	-2.0	-2.0
Liver weight, left	1.3	2.1	3.7	1.5	1.9	-1.5	-1.6	1.2	0.3
Liver weight, right	1.2	2.0	3.9	1.5	2.0	-1.5	-1.6	1.1	0.2
Locomotor activity	1.0	1.5	2.2	-1.5	-1.2	1.5	1.0	-1.1	-0.9
Locomotor testing distance	2.7	4.5	5.9	-2.4	-2.0	2.4	2.0	-2.1	-1.8
Locomotor testing rearing	1.9	3.0	3.5	-1.9	-1.3	1.9	1.6	-1.7	-1.9
Locomotion in novel chamber	2.7	3.3	3.9	1.8	1.7	-1.8	-2.0	1.9	1.6
Locomotion in novel chamber post-restriction	0.4	0.5	1.0	0.8	1.0	-0.8	-0.7	0.3	-0.1
Fecal boli incidents, locomotor time 1	1.2	1.3	2.2	-1.1	-0.6	1.1	0.9	-1.4	-1.5
Change in fecal boli incidents, locomotor task	0.4	0.3	0.9	0.5	0.1	-0.5	-0.4	0.7	1.0
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.6	-0.6	-0.5	0.6	0.6	-0.8	-0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.0	-0.2	0.0	-0.1	0.2	0.5
Total resting periods, locomotor time 1	0.3	0.4	0.6	-0.7	-0.8	0.7	0.6	-0.5	-0.1
Rest time, locomotor task time 1	0.7	0.7	0.9	-1.0	-0.9	1.0	0.9	-0.8	-0.5
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	-0.2	-0.1	0.0	0.0	0.2
Vertical activity count, locomotor time 1	1.0	1.1	1.3	1.1	0.9	-1.1	-1.0	1.1	1.0
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.7	-0.5	-0.5	0.5	0.7	-0.8	-0.8
Bouts of movement, locomotor time 2	3.0	3.2	3.7	1.9	1.8	-1.9	-1.9	1.8	1.4
Total resting periods, locomotor time 2	3.6	3.8	4.2	2.1	1.9	-2.1	-2.0	2.0	1.7
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.3	-0.4	0.3	0.4	-0.2	0.1
Distance moved, locomotor task time 2	0.1	0.1	0.1	-0.2	-0.4	0.2	0.3	-0.2	-0.0
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.5	0.3	-0.5	-0.2	0.3	0.4
Light reinforcement 1	0.6	1.0	1.7	-1.1	-1.3	1.1	1.2	-0.9	-0.3
Light reinforcement 2	0.1	0.1	0.2	0.3	0.0	-0.3	-0.2	0.3	0.4
Bone: marrow area	5.5	12.0	17.1	3.8	4.1	-3.8	-3.6	3.2	1.6
Bone: maximum diameter	1.3	2.5	3.3	1.6	1.8	-1.6	-1.8	1.6	0.7
Bone: maximum force	11.3	19.5	24.7	4.8	5.0	-4.8	-4.5	4.3	2.7
Bone: maximum moment	12.6	21.7	28.5	5.1	5.3	-5.1	-4.7	4.4	2.7
Mean time between licks in bursts	0.1	0.1	0.4	-0.0	-0.5	0.0	0.7	-0.5	-0.1
Mean num. licks in bursts	0.5	0.6	1.4	0.8	1.2	-0.8	-0.4	0.4	-0.5
Cd content in liver	0.4	0.5	0.7	-0.7	-0.6	0.7	0.6	-0.8	-0.6
Co content in liver	0.2	0.3	0.6	-0.7	-0.4	0.7	-0.1	-0.5	-0.4
Cu content in liver	0.2	0.3	0.5	0.5	0.7	-0.5	-0.6	0.4	-0.3
Fe content in liver	0.8	1.0	1.1	-1.0	-1.1	1.0	0.8	-1.1	-1.0
K content in liver	0.0	0.0	0.1	-0.2	-0.3	0.2	0.2	-0.2	-0.2
Mg content in liver	0.2	0.2	0.3	-0.4	-0.5	0.4	0.4	-0.3	-0.0
Mn content in liver	0.2	0.2	0.5	0.4	0.3	-0.4	-0.3	0.6	0.7
Na content in liver	0.2	0.2	0.4	-0.5	-0.4	0.5	0.2	-0.3	-0.6
Rb content in liver	1.9	2.4	2.9	-1.7	-1.3	1.7	1.4	-1.6	-1.5
Se content in liver	1.5	1.9	2.5	-1.6	-1.6	1.6	1.2	-1.3	-0.8
Sr content in liver	0.2	0.2	0.8	0.1	0.4	-0.1	0.0	-0.3	-0.9
Zn content in liver	2.4	2.6	3.2	-1.8	-1.5	1.8	1.5	-1.7	-1.4
Bone: minimum diameter	6.8	12.7	15.5	3.9	3.9	-3.9	-3.7	3.4	2.1
Time in familiar zone, hab. session 1	0.1	0.1	0.4	0.2	-0.0	-0.2	-0.2	0.2	0.6
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1
Total zone transitions, hab. session 1	0.3	0.4	1.5	-0.2	-0.9	0.2	0.2	0.4	1.2
Total locomotion distance, hab. session 1	0.4	0.5	1.0	-0.7	-1.0	0.7	0.9	-0.5	0.1
Locomotion velocity, hab. session 1	0.2	0.3	0.6	-0.6	-0.8	0.6	0.7	-0.3	0.2
Time in familiar zone, hab. session 2	1.5	1.5	1.9	1.3	1.4	-1.3	-1.2	1.1	1.0
Time in novel zone, hab. session 2	1.7	1.7	2.1	-1.4	-1.5	1.4	1.3	-1.1	-0.9
Total zone transitions, hab. session 2	0.2	0.3	0.5	-0.6	-0.7	0.6	0.6	-0.4	-0.4
Total locomotion distance, hab. session 2	0.5	0.6	0.8	-0.8	-0.8	0.8	0.9	-0.8	-0.6
Locomotion velocity, hab. session 2	0.3	0.4	0.5	-0.6	-0.6	0.6	0.6	-0.6	-0.7
Novel to familiar place preference ratio	1.7	1.7	2.6	1.1	0.9	-1.1	-1.4	1.6	1.6
Novelty place preference	1.1	1.1	1.9	0.8	0.6	-0.8	-1.1	1.3	1.4
Time in novel zone, NPP test	0.8	0.9	1.9	0.7	0.4	-0.7	-0.9	1.2	1.4
Total zone transitions, NPP test	2.4	3.4	4.9	-2.0	-2.2	2.0	1.9	-1.6	-1.0
Total locomotion distance, NPP test	3.5	4.7	5.7	-2.3	-2.4	2.3	2.4	-2.2	-1.5
Locomotion velocity, NPP test	2.3	3.3	3.8	-1.9	-1.9	1.9	2.0	-1.8	-1.4
Intraocular pressure	4.3	6.0	7.2	-2.5	-2.2	2.5	2.7	-2.7	-2.1
Delta distance traveled before/after self-admin	0.4	0.4	1.0	0.4	1.0	-0.4	-0.5	-0.1	-0.9
Delta ambulatory time before/after self-admin	0.4	0.4	1.4	0.3	0.8	-0.3	-0.2	-0.3	-1.2
Parametrial fat weight	1.1	2.2	3.6	-1.5	-1.0	1.5	1.1	-1.9	-1.7
Pavlov. Cond. lever latency	0.4	0.5	1.2	-0.4	-0.3	0.4	0.8	-1.0	-1.1
Pavlov. Cond. magazine entry latency	1.2	1.6	2.3	1.1	0.9	-1.1	-1.2	1.5	1.5
Pavlov. Cond. change in total contacts	1.9	2.1	3.4	1.2	0.9	-1.2	-1.5	1.7	1.9
Pavlov. Cond. index score	1.2	1.6	2.6	0.9	0.7	-0.9	-1.3	1.6	1.6
Pavlov. Cond. latency score	1.0	1.3	2.2	0.8	0.7	-0.8	-1.3	1.5	1.5
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.3	0.2	-0.3	-0.7	0.7	0.7
Pavlov. Cond. magazine entry number	0.5	0.6	0.9	-0.6	-0.7	0.6	0.8	-0.9	-0.9
Pavlov. Cond. intertrial magazine entries	4.7	5.6	6.6	-2.5	-2.4	2.5	2.6	-2.5	-1.8
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	3.0	1.1	0.9	-1.1	-1.5	1.7	1.7
Pavlov. Cond. response bias	0.4	0.5	0.8	0.6	0.5	-0.6	-0.8	0.9	0.8
Pavlov. Cond. lever latency	0.9	1.2	1.8	1.1	0.9	-1.1	-0.8	1.3	1.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	-0.3	-0.2	0.3	0.2	-0.8	-0.7
Pavlov. Cond. change in total contacts	0.8	1.0	1.9	0.7	0.5	-0.7	-1.3	1.2	1.4
Pavlov. Cond. index score	0.4	0.5	0.9	-0.7	-0.6	0.7	0.4	-0.9	-0.9
Pavlov. Cond. latency score	0.4	0.5	0.8	-0.7	-0.6	0.7	0.3	-0.9	-0.8
Pavlov. Cond. lever contacts	0.9	1.2	2.0	-1.0	-0.8	1.0	0.8	-1.3	-1.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.0	0.0	-0.0	0.1	0.3	0.2
Pavlov. Cond. intertrial magazine entries	2.0	2.5	4.6	-1.6	-0.8	1.6	1.5	-1.7	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.4	-0.4	0.4	0.1	-0.6	-0.5
Pavlov. Cond. response bias	0.5	0.6	1.2	-0.7	-0.5	0.7	0.5	-1.1	-1.1
Time in closed arm before self-admin	0.9	1.1	1.6	1.0	0.7	-1.0	-1.0	1.2	1.3
Time in closed arm after self-admin	0.6	0.6	1.5	0.6	0.3	-0.6	-0.7	1.0	1.2
Time in open arm before self-admin	0.4	0.5	2.2	0.2	-0.3	-0.2	-0.2	0.7	1.5
Time in open arm after self-admin	0.2	0.2	0.4	-0.4	-0.6	0.4	0.5	-0.5	-0.2
Bone: periosteal estimation	7.6	15.8	21.9	4.3	4.7	-4.3	-4.3	3.8	1.9
Bone: periosteal perimeter	7.9	13.2	15.7	3.9	4.0	-3.9	-3.9	3.6	2.3
Bone: post-yield work	6.4	8.7	11.9	3.2	3.4	-3.2	-3.0	2.8	1.6
Progressive ratio test 1 active lever presses	8.5	8.9	10.4	-2.9	-2.6	2.9	3.1	-3.2	-3.1
Progressive ratio test 1 breakpoint	7.1	7.5	8.5	-2.7	-2.4	2.7	2.8	-2.9	-2.8
Progressive ratio test 1 inactive lever presses	2.2	2.4	2.7	-1.5	-1.4	1.5	1.5	-1.6	-1.6
Progressive ratio test 2 active lever presses	2.1	2.3	3.6	-1.4	-1.1	1.4	1.4	-1.7	-1.9
Progressive ratio test 2 breakpoint	2.2	2.4	3.7	-1.5	-1.2	1.5	1.4	-1.7	-1.9
Progressive ratio test 2 inactive lever presses	1.4	1.6	3.3	-1.1	-0.8	1.1	1.2	-1.5	-1.8
Incentive Sensitization - Responses	0.4	0.4	0.7	0.5	0.7	-0.5	-0.9	0.7	0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	0.4	0.6	-0.4	-0.8	0.6	0.2
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.7	-0.6	-0.8	0.6	0.7	-0.7	-0.4
Progressive ratio	1.0	1.1	1.3	-1.1	-1.1	1.1	1.1	-1.1	-0.7
Food seeking constrained by brief footshock	1.8	2.3	2.9	-1.5	-1.5	1.5	1.7	-1.6	-1.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3	0.3	0.1
Retroperitoneal fat weight	1.1	3.5	4.9	-1.9	-1.3	1.9	1.5	-2.2	-2.2
Reaction time number correct	0.9	1.3	3.0	1.3	1.7	-1.3	-0.8	0.8	-0.3
Reaction time mean minus median	4.7	6.2	7.5	-2.7	-2.4	2.7	2.3	-2.4	-2.3
Reaction time mean minus median AUC	3.2	4.2	5.3	-2.3	-2.2	2.3	2.0	-1.8	-1.5
Reaction time num false alarms	1.3	1.7	2.7	-1.4	-1.6	1.4	1.6	-1.2	-0.2
Reaction time num false alarms AUC	1.5	2.0	3.2	-1.5	-1.8	1.5	1.7	-1.1	0.1
Reaction time trials correct on left	0.9	1.3	3.0	1.3	1.7	-1.3	-0.8	0.8	-0.3
Reaction time trials on left	0.7	1.0	2.5	1.1	1.6	-1.1	-0.7	0.6	-0.4
Reaction time mean	0.6	0.9	1.4	-1.0	-0.7	1.0	0.7	-1.0	-1.2
Reaction time mean AUC	0.4	0.5	0.9	-0.8	-0.5	0.8	0.4	-0.7	-1.0
Median of all reaction times	0.0	0.1	0.3	-0.1	0.1	0.1	-0.1	-0.3	-0.5
Reaction time omissions	7.0	9.5	10.4	-3.2	-3.0	3.2	3.2	-3.2	-2.8
Reaction time false alarm rate	1.6	2.3	4.6	-1.6	-2.1	1.6	1.6	-1.0	0.5
Reaction time premature initiation rate	4.2	5.6	6.5	-2.5	-2.1	2.5	2.4	-2.6	-2.2
Reaction time premature initiations	2.2	3.1	5.1	-1.6	-1.1	1.6	1.8	-2.0	-2.3
Std. dev. reaction times	4.0	5.6	6.9	-2.6	-2.4	2.6	2.3	-2.2	-2.0
Reaction time trials completed	0.7	1.0	2.5	1.1	1.6	-1.1	-0.7	0.6	-0.4
Reaction time trials AUC	1.2	1.7	3.5	1.5	1.9	-1.5	-1.0	1.0	-0.1
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.8	0.9	-0.8	-0.4	0.3	-0.2
Run reversals in cocaine runway, males	0.6	0.6	1.3	-0.7	-1.2	0.7	0.9	-0.3	0.1
Latency to leave start box in cocaine runway	0.3	0.3	1.4	-0.2	-0.5	0.2	0.1	0.3	1.2
Latency to leave start box in cocaine runway, F	1.5	1.7	3.5	-1.4	-1.9	1.4	1.4	-0.8	0.4
Latency to leave start box in cocaine runway, M	2.2	2.1	2.7	1.4	1.5	-1.4	-1.6	1.5	1.3
Std. dev. time between licks in bursts	1.1	1.4	1.6	-1.1	-1.2	1.1	1.2	-1.3	-1.0
Total sessions with >9 infusions	1.6	1.8	2.2	-1.3	-1.1	1.3	1.3	-1.5	-1.5
Short access day 1 total inactive lever presses	1.1	1.2	1.5	-1.2	-1.0	1.2	1.1	-1.2	-1.0
Short access day 10 total inactive lever presses	0.1	0.1	0.3	0.3	0.5	-0.3	-0.3	0.0	-0.5
Short access day 1 total infusions	0.8	0.8	1.7	-0.9	-0.6	0.9	0.7	-1.0	-1.3
Short access day 10 total infusions	2.9	3.2	3.9	-1.7	-1.6	1.7	2.0	-2.0	-1.8
Short access total infusions	2.1	2.3	3.5	-1.4	-1.1	1.4	1.5	-1.7	-1.9
Short access day 1 locomotion	0.2	0.2	0.3	-0.5	-0.5	0.5	0.3	-0.5	-0.4
Short access day 10 total locomotion	0.2	0.3	0.6	-0.5	-0.3	0.5	0.5	-0.5	-0.8
Short access total locomotion	0.6	0.6	0.8	-0.7	-0.7	0.7	0.9	-0.8	-0.9
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.2	0.3	-0.2	-0.4	0.2	0.1
Compulsive drug intake	2.1	2.1	3.2	1.3	1.2	-1.3	-1.6	1.5	1.8
One hour access (shock baseline)	0.1	0.1	0.3	0.1	0.2	-0.1	-0.0	-0.1	-0.6
Social response proportion	0.2	0.2	1.0	-0.2	0.2	0.2	-0.1	-0.6	-1.0
Social responses	3.7	4.8	6.6	-2.6	-2.3	2.6	2.0	-2.1	-1.3
Social time	0.3	0.3	0.9	0.5	0.9	-0.5	-0.6	0.2	-0.4
Soleus weight	0.9	2.6	3.3	1.7	1.8	-1.7	-1.7	1.6	0.9
Bone: stiffness	15.4	24.3	28.2	5.3	5.3	-5.3	-5.1	4.9	3.3
Tibialis anterior weight	4.3	14.6	27.7	3.2	2.1	-3.2	-3.8	4.5	5.3
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.9	-0.9	-0.9	0.9	0.8	-0.6	-0.1
Time to tail flick, vehicle, after self-admin	0.5	0.6	0.8	0.7	0.6	-0.7	-0.8	0.9	0.8
Time to tail flick, test, before self-admin	0.2	0.2	0.5	-0.3	-0.7	0.3	0.6	-0.1	0.2
Time to tail flick, test, after self-admin	0.7	0.7	1.1	1.0	1.0	-1.0	-0.8	0.7	0.2
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.2	0.9	1.1	-0.9	-1.0	0.6	0.0
Delta time to tail flick, test, before/after SA	0.8	0.7	1.2	0.9	1.1	-0.9	-1.0	0.7	0.2
Tibia length	3.6	10.3	16.3	3.4	4.0	-3.4	-3.7	2.7	1.0
Ambulatory time before self-admin	3.7	3.8	4.4	-2.1	-2.0	2.1	2.0	-2.0	-1.4
Ambulatory time after self-admin	2.0	2.2	3.5	-1.3	-0.9	1.3	1.4	-1.7	-1.9
Bone: tissue strength	1.8	1.8	2.3	1.4	1.2	-1.4	-1.2	1.4	1.5
Total heroin consumption	0.9	1.1	2.2	1.0	1.5	-1.0	-1.2	0.7	0.1
Bone: trabecular number	2.9	4.6	7.4	2.4	2.7	-2.4	-2.1	1.8	0.6
Bone: trabecular spacing	0.8	1.0	1.7	-1.2	-1.3	1.2	0.8	-0.7	-0.1
Bone: trabecular thickness	0.5	0.6	0.9	0.8	0.6	-0.8	-0.6	0.9	0.8
Bone: trabecular tissue density	1.2	1.7	4.5	1.1	0.2	-1.1	-0.9	1.6	2.1
Water consumed over 24 hours	0.4	0.5	1.8	-0.4	0.3	0.4	0.3	-0.8	-1.3
Number of responses in last shaping day	0.3	0.3	0.5	0.7	0.5	-0.7	-0.4	0.5	0.6