Hub : Genes

Orc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Orc3 0.02 0.02 6.4e-03 0 0 0 0 2.6e-01 8.0e-02 8.9e-02 3.4e-01
2 Adipose gene expression Orc3 0.03 0.02 1.1e-03 0.02 0.02 0.01 0.01 2.2e-03 3.1e-03 6.7e-03 8.8e-03
3 Liver gene expression Orc3 0.03 0.03 2.2e-03 0.01 0.01 0 0.01 1.0e-02 1.3e-02 1.6e-01 2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.71.41.7-1.31.11.2
Area under the delay curve0.10.10.20.4-0.3-0.4
BMI with tail3.110.912.7-2.83.63.5
BMI without tail1.78.99.5-3.13.02.9
Body weight6.227.128.8-4.95.45.3
Weight adjusted by age0.72.02.2-1.51.41.4
Bone surface1.83.55.1-2.31.61.7
Bone volume0.91.92.9-1.71.11.2
Breakpoint value in progressive ratio session0.20.40.6-0.80.60.6
Number of licking bursts0.10.20.30.2-0.4-0.5
Context. condit. distance diff. score0.91.11.41.2-1.1-0.8
Locomotion velocity, session 10.10.10.30.5-0.3-0.2
Locomotion distance, session 13.74.85.02.2-2.2-2.1
Locomotion velocity, session 20.10.10.20.40.20.1
Locomotion distance, session 25.57.79.73.1-2.6-2.6
Locomotion velocity, session 32.52.94.12.0-1.5-1.6
Locomotion distance, session 33.64.16.12.5-1.9-1.7
Stereotopy head waving bouts, day 30.81.01.5-1.20.90.8
Stereotopy head waving duration, day 31.51.92.0-1.41.31.4
Locomotion velocity, session 70.80.81.71.3-0.8-0.4
Locomotion distance, session 72.43.04.22.0-1.7-1.4
Stereotopy head waving bouts, day 70.10.20.3-0.10.40.5
Stereotopy head waving duration, day 71.62.02.6-1.01.61.6
Locomotion velocity, session 85.26.39.43.1-2.4-1.9
Locomotion distance, session 87.410.712.83.6-3.2-3.1
Degree of sensitization distance0.30.30.5-0.50.60.7
Degree of sensitization stereotypy0.20.20.30.30.60.6
Conditioned locomotion0.20.20.4-0.70.40.3
Cocaine response after cond. corrected0.50.71.0-0.90.61.0
Cocaine response after cond. not corrected0.20.20.3-0.60.20.6
Cocaine response before conditioning0.10.10.20.3-0.1-0.4
Saline control response0.81.11.6-1.30.81.0
Bone: connectivity density1.32.12.3-1.51.41.5
Bone: cortical apparent density0.00.10.1-0.1-0.3-0.3
Bone: cortical area3.96.36.6-2.62.52.4
Bone: cortical porosity0.10.20.4-0.60.1-0.2
Bone: cortical porosity0.60.71.2-1.10.80.5
Bone: cortical thickness0.81.41.5-1.21.11.2
Bone: cortical thickness0.20.30.6-0.00.50.8
Bone: cortical tissue density0.10.10.1-0.0-0.4-0.4
Condit. Reinf. active minus inactive responses2.83.23.71.9-1.8-1.7
Condit. Reinf. active-inactive response ratio0.80.80.90.9-0.9-1.0
Condit. Reinf. active responses1.72.23.01.7-1.4-1.3
Condit. Reinf. inactive responses0.70.91.51.2-0.8-0.8
Incentive salience index mean0.91.21.61.3-1.0-1.0
Condit. Reinf. lever presses0.00.00.10.4-0.10.0
Condit. Reinf. active minus inactive responses0.50.81.1-0.51.11.0
Condit. Reinf. active-inactive response ratio0.10.20.30.50.30.5
Condit. Reinf. active responses1.01.51.8-1.21.31.2
Condit. Reinf. inactive responses0.71.01.7-1.30.90.7
Condit. Reinf. lever presses1.52.22.8-1.21.71.5
Condit. Reinf. lever reinforcers received1.52.02.5-1.31.61.4
Conditioned reinforcement - actives0.10.40.4-0.50.60.7
Conditioned reinforcement - inactives0.00.00.00.10.1-0.2
Conditioned locomotion1.01.42.0-1.11.01.4
Patch foraging indifference point 0 sec0.10.20.3-0.60.50.3
Patch foraging indifference point AUC1.12.64.0-1.41.22.0
Delay disc. indifference point, 0s delay0.50.60.80.9-0.7-0.7
Delay disc. indifference point, 16s delay0.00.00.1-0.30.20.1
Delay disc. indifference point, 2s delay0.10.10.1-0.40.30.2
Delay disc. indifference point, 24s delay0.00.00.00.00.0-0.1
Delay disc. indifference point, 4s delay0.40.40.50.7-0.6-0.6
Delay disc. indifference point, 8s delay0.00.00.00.00.2-0.2
Indifference point function ln k0.10.40.70.6-0.1-0.8
Indifference point function log k0.10.40.70.6-0.1-0.8
Patch foraging total patch changes 0 sec0.00.10.2-0.30.40.2
Patch foraging total patch changes 12 sec1.01.32.3-0.61.11.5
Patch foraging total patch changes 18 sec0.00.10.2-0.50.20.3
Patch foraging total patch changes 24 sec0.51.62.0-1.41.01.4
Patch foraging total patch changes 6 sec0.30.40.5-0.70.60.7
Patch foraging time to switch 0 sec0.72.63.31.5-1.5-1.8
Patch foraging water rate 0 sec0.52.02.2-1.41.41.5
Patch foraging water rate 12 sec0.00.20.2-0.50.40.3
Patch foraging water rate 18 sec0.00.10.20.40.10.2
Patch foraging water rate 24 sec0.20.20.60.80.1-0.3
Patch foraging water rate 6 sec0.20.30.5-0.40.70.6
Seeking ratio, delayed vs. immediate footshock0.10.20.2-0.40.40.4
Distance traveled before self-admin0.00.00.00.1-0.10.1
Distance traveled after self-admin0.10.20.30.5-0.1-0.4
Extensor digitorum longus weight4.317.318.4-4.04.24.3
Bone: elastic displacement0.10.10.2-0.0-0.3-0.4
Bone: elastic work1.82.43.1-1.81.51.3
Bone: endosteal estimation4.110.011.7-3.13.43.0
Bone: endosteal perimeter2.76.67.4-2.72.72.3
Epididymis fat weight0.00.10.2-0.4-0.1-0.1
Delta time in closed arm before/after self-admin0.10.10.2-0.0-0.40.0
Delta time in open arm before/after self-admin0.10.20.40.6-0.1-0.3
Diff in mean of infusions in LGA sessions0.61.01.20.8-1.0-1.1
Delay discount exponential model param0.10.20.2-0.50.30.4
Extinction: sum of active levers before priming0.60.91.51.2-0.8-0.8
Active lever presses in extinction session 61.11.11.70.8-1.3-1.0
Bone: final force2.64.34.6-2.22.12.0
Bone: final moment3.65.86.2-2.52.52.3
Food consumed during 24 hour testing period1.22.32.5-1.51.41.6
Glucose0.00.00.0-0.2-0.10.1
Heart weight1.82.93.4-1.81.61.7
Delay discount hyperbolic model param0.00.00.1-0.20.20.2
Intermittent access intake day 1-15 change0.42.22.41.5-1.6-1.4
Intermittent access intake escalation0.42.02.41.4-1.5-1.3
Intermittent access intake escalation 20.91.52.11.5-1.2-1.1
Intermitt. access day 1 inactive lever presses0.00.30.30.5-0.5-0.5
Intermitt. access day 15 inactive lever presses0.00.10.2-0.1-0.4-0.1
Intermitt. access escalation Index0.00.10.20.0-0.5-0.4
Intermittent access day 1 total infusions0.30.81.0-0.80.91.0
Intermittent access day 15 total infusions0.00.00.10.1-0.00.3
Intermittent access terminal intake (last 3 days)0.10.10.20.4-0.3-0.1
Intermittent access total infusions0.60.71.1-0.60.81.0
Intermittent access day 1 locomotion0.30.61.1-1.00.60.6
Intermittent access day 15 total locomotion0.10.40.6-0.80.60.4
Intermittent access total locomotion0.40.50.9-0.90.60.6
Intermittent access standard deviation0.10.40.80.9-0.6-0.3
Left kidney weight1.18.610.8-2.82.73.3
Right kidney weight1.07.38.5-2.82.42.9
Cocaine induced anxiety0.10.40.60.8-0.5-0.6
Post-drug Anxiety0.00.00.00.10.10.1
Baseline Anxiety0.00.00.1-0.3-0.00.2
Tail length1.15.99.4-3.12.02.1
Length with tail3.113.615.7-4.03.43.6
Length without tail0.94.55.8-1.82.12.4
Times rat made contact with spout0.10.10.2-0.4-0.00.3
Lifetime Intake0.50.71.0-0.50.81.0
Liver weight, left2.13.76.1-2.51.71.5
Liver weight, right1.12.02.7-1.71.11.4
Locomotor activity0.71.11.70.9-1.0-1.3
Locomotor testing distance0.20.40.80.4-0.4-0.9
Locomotor testing rearing0.41.41.71.2-1.0-1.3
Locomotion in novel chamber0.91.31.9-0.91.41.1
Locomotion in novel chamber post-restriction0.10.20.50.3-0.3-0.7
Fecal boli incidents, locomotor time 10.10.20.5-0.7-0.10.4
Change in fecal boli incidents, locomotor task0.00.00.1-0.10.2-0.2
Time >=10cm from walls, locomotor time 10.00.00.1-0.10.10.3
Bouts of movement, locomotor time 10.30.40.60.5-0.8-0.5
Total resting periods, locomotor time 10.10.10.3-0.0-0.6-0.3
Rest time, locomotor task time 10.10.10.40.1-0.6-0.2
Distance moved, locomotor task time 10.10.40.7-0.30.90.6
Vertical activity count, locomotor time 10.00.10.10.20.20.3
Time >=10cm from walls, locomotor time 20.61.71.7-1.31.31.3
Bouts of movement, locomotor time 20.00.00.00.10.10.1
Total resting periods, locomotor time 20.00.00.00.1-0.20.0
Rest time, locomotor task time 20.20.40.70.5-0.8-0.4
Distance moved, locomotor task time 20.10.20.20.50.5-0.0
Vertical activity count, locomotor time 20.20.40.8-0.10.90.8
Light reinforcement 10.62.84.4-1.11.72.1
Light reinforcement 20.92.12.9-1.11.51.7
Bone: marrow area4.110.111.8-3.13.43.0
Bone: maximum diameter4.38.69.8-3.12.92.7
Bone: maximum force3.67.17.7-2.62.82.6
Bone: maximum moment4.48.28.8-2.83.02.8
Mean time between licks in bursts0.10.50.8-0.60.90.6
Mean num. licks in bursts0.10.20.4-0.40.30.6
Cd content in liver2.62.93.2-1.81.71.6
Co content in liver0.10.10.2-0.40.20.2
Cu content in liver0.00.00.0-0.1-0.0-0.2
Fe content in liver0.20.20.4-0.6-0.2-0.4
K content in liver1.11.01.20.9-1.1-1.1
Mg content in liver0.10.10.20.2-0.4-0.3
Mn content in liver0.30.30.5-0.50.40.7
Na content in liver2.12.43.01.2-1.6-1.7
Rb content in liver0.60.71.10.8-1.0-0.7
Se content in liver2.22.53.21.2-1.8-1.7
Sr content in liver1.91.61.71.3-1.2-1.3
Zn content in liver0.10.10.1-0.20.40.2
Bone: minimum diameter1.73.44.0-1.72.01.7
Time in familiar zone, hab. session 11.21.31.8-1.10.91.4
Time in novel zone, hab. session 14.45.05.82.4-2.1-2.2
Total zone transitions, hab. session 19.012.614.82.9-3.8-3.8
Total locomotion distance, hab. session 15.57.810.02.0-3.2-3.1
Locomotion velocity, hab. session 13.85.37.01.4-2.6-2.6
Time in familiar zone, hab. session 20.00.00.10.30.10.2
Time in novel zone, hab. session 20.00.00.0-0.10.0-0.1
Total zone transitions, hab. session 24.96.26.72.4-2.6-2.5
Total locomotion distance, hab. session 21.21.52.00.8-1.4-1.4
Locomotion velocity, hab. session 20.91.21.80.6-1.2-1.3
Novel to familiar place preference ratio0.20.20.6-0.8-0.2-0.1
Novelty place preference0.20.20.3-0.5-0.5-0.5
Time in novel zone, NPP test0.20.30.4-0.4-0.6-0.6
Total zone transitions, NPP test3.34.95.32.3-2.3-2.0
Total locomotion distance, NPP test0.60.80.80.9-0.9-0.8
Locomotion velocity, NPP test0.30.40.40.6-0.7-0.6
Intraocular pressure2.54.14.8-2.02.21.9
Delta distance traveled before/after self-admin0.10.10.10.20.0-0.4
Delta ambulatory time before/after self-admin0.10.10.30.4-0.1-0.5
Parametrial fat weight0.61.42.41.6-0.8-1.1
Pavlov. Cond. lever latency0.30.40.50.7-0.6-0.6
Pavlov. Cond. magazine entry latency0.20.20.7-0.80.20.1
Pavlov. Cond. change in total contacts0.20.20.30.2-0.6-0.5
Pavlov. Cond. index score0.20.20.5-0.70.20.2
Pavlov. Cond. latency score0.30.40.8-0.90.50.5
Pavlov. Cond. lever contacts0.40.40.7-0.80.50.5
Pavlov. Cond. magazine entry number0.30.40.90.9-0.4-0.4
Pavlov. Cond. intertrial magazine entries2.12.63.51.9-1.5-1.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.50.00.1
Pavlov. Cond. response bias0.20.20.6-0.80.20.3
Pavlov. Cond. lever latency0.50.71.00.7-1.0-0.9
Pavlov. Cond. magazine entry latency0.50.81.30.8-0.6-1.2
Pavlov. Cond. change in total contacts0.20.40.7-0.40.80.7
Pavlov. Cond. index score0.00.00.1-0.00.3-0.1
Pavlov. Cond. latency score0.20.40.7-0.60.80.4
Pavlov. Cond. lever contacts0.30.50.7-0.60.80.7
Pavlov. Cond. magazine entry number0.30.40.6-0.60.30.8
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.3-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.00.2-0.1
Pavlov. Cond. response bias0.00.00.10.30.1-0.1
Time in closed arm before self-admin1.42.43.4-1.11.91.6
Time in closed arm after self-admin0.70.81.0-0.80.91.0
Time in open arm before self-admin0.20.30.4-0.6-0.6-0.1
Time in open arm after self-admin0.40.40.50.5-0.7-0.7
Bone: periosteal estimation5.513.014.4-3.63.83.5
Bone: periosteal perimeter5.711.312.3-3.53.53.1
Bone: post-yield work0.71.21.2-1.11.01.1
Progressive ratio test 1 active lever presses0.10.20.3-0.50.40.6
Progressive ratio test 1 breakpoint0.10.20.3-0.40.40.6
Progressive ratio test 1 inactive lever presses0.41.21.30.9-1.2-1.1
Progressive ratio test 2 active lever presses0.10.10.1-0.20.30.4
Progressive ratio test 2 breakpoint0.10.10.1-0.20.40.4
Progressive ratio test 2 inactive lever presses0.00.00.1-0.1-0.3-0.1
Incentive Sensitization - Responses0.00.00.00.20.2-0.2
Incentive Sensitization - Breakpoint0.00.00.10.00.3-0.0
Sum of active levers in priming session hrs 5-60.00.00.00.10.10.2
Progressive ratio0.00.10.1-0.40.00.3
Food seeking constrained by brief footshock8.110.111.8-2.63.43.4
Seeking ratio, punishment vs. effort0.61.32.0-0.71.41.2
Retroperitoneal fat weight1.04.35.72.4-2.1-1.7
Reaction time number correct0.31.11.3-1.11.01.0
Reaction time mean minus median0.31.92.11.4-1.3-1.4
Reaction time mean minus median AUC0.21.41.61.3-1.2-1.1
Reaction time num false alarms0.10.20.4-0.10.40.6
Reaction time num false alarms AUC0.20.40.6-0.30.70.8
Reaction time trials correct on left0.31.11.3-1.11.01.0
Reaction time trials on left0.41.31.6-1.31.11.1
Reaction time mean0.10.10.2-0.20.40.4
Reaction time mean AUC0.00.10.1-0.20.30.3
Median of all reaction times0.50.81.0-0.70.91.0
Reaction time omissions1.11.72.3-1.51.31.0
Reaction time false alarm rate0.10.10.30.5-0.3-0.2
Reaction time premature initiation rate0.20.20.4-0.40.50.6
Reaction time premature initiations0.51.51.7-1.11.21.3
Std. dev. reaction times0.20.81.01.0-0.7-0.9
Reaction time trials completed0.41.31.6-1.31.11.1
Reaction time trials AUC0.31.11.4-1.21.01.0
Run reversals in cocaine runway, females0.10.10.2-0.40.30.3
Run reversals in cocaine runway, males0.40.40.70.8-0.6-0.5
Latency to leave start box in cocaine runway0.81.11.6-1.31.10.6
Latency to leave start box in cocaine runway, F0.50.71.0-1.00.80.6
Latency to leave start box in cocaine runway, M0.20.20.3-0.50.4-0.2
Std. dev. time between licks in bursts0.40.81.1-0.81.10.8
Total sessions with >9 infusions0.00.00.0-0.10.20.1
Short access day 1 total inactive lever presses0.10.20.40.7-0.3-0.2
Short access day 10 total inactive lever presses0.42.83.31.8-1.7-1.5
Short access day 1 total infusions0.30.60.60.8-0.8-0.8
Short access day 10 total infusions0.10.10.2-0.40.20.5
Short access total infusions0.10.10.1-0.20.30.4
Short access day 1 locomotion0.20.30.70.1-0.6-0.8
Short access day 10 total locomotion0.10.30.9-1.00.20.2
Short access total locomotion0.10.20.6-0.80.10.2
One hour access (0.3 mA shock)0.00.10.10.30.10.2
Compulsive drug intake0.10.20.30.6-0.4-0.3
One hour access (shock baseline)0.10.20.3-0.40.50.5
Social response proportion3.44.35.42.3-1.9-2.0
Social responses0.30.51.01.0-0.5-0.4
Social time0.10.20.30.5-0.5-0.2
Soleus weight2.16.17.5-2.72.42.2
Bone: stiffness0.61.01.1-1.01.00.9
Tibialis anterior weight6.422.125.3-4.05.05.0
Time to tail flick, vehicle, before self-admin0.10.10.20.0-0.3-0.4
Time to tail flick, vehicle, after self-admin0.20.40.8-0.90.30.5
Time to tail flick, test, before self-admin0.40.50.9-0.51.00.5
Time to tail flick, test, after self-admin1.51.61.9-1.41.31.0
Delta time to tail flick, vehicle, before/after SA0.20.20.3-0.60.30.4
Delta time to tail flick, test, before/after SA0.10.10.1-0.4-0.3-0.2
Tibia length1.43.83.9-1.91.92.0
Ambulatory time before self-admin0.10.20.30.5-0.5-0.4
Ambulatory time after self-admin0.00.10.10.30.1-0.3
Bone: tissue strength0.70.81.10.9-0.7-1.0
Total heroin consumption0.60.81.2-1.10.90.6
Bone: trabecular number0.30.50.7-0.90.70.7
Bone: trabecular spacing0.30.50.8-0.00.80.9
Bone: trabecular thickness0.20.30.9-1.00.20.1
Bone: trabecular tissue density3.76.58.42.9-2.3-2.4
Water consumed over 24 hours1.12.22.9-1.71.31.4
Number of responses in last shaping day2.02.62.9-1.61.51.7