Hub : Genes

Myo1c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Myo1c 0.03 0.03 4.5e-03 0.02 0.01 0.01 0.01 3.4e-03 8.0e-03 7.0e-02 9.4e-03
2 Adipose intron excision ratio chr10_60499487_60505081 0.08 0.05 8.4e-06 0.03 0.03 0.03 0.03 1.2e-04 3.8e-04 4.1e-04 2.7e-04
3 Brain alternative TSS NM_001414168.1 0.03 0.02 3.4e-03 0.01 0.02 0.03 0.01 3.0e-02 1.0e-02 1.1e-03 2.4e-02
4 Adipose gene expression Myo1c 0.2 0.12 9.7e-05 0.02 0.03 0.03 0.02 4.8e-03 2.9e-04 3.8e-04 3.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density3.25.48.42.9-2.8-2.1-1.0
Area under the delay curve1.51.62.4-1.61.51.10.7
BMI with tail1.03.24.72.1-2.2-1.1-1.6
BMI without tail0.20.31.00.4-0.4-1.0-0.0
Body weight0.93.78.91.6-1.7-3.00.8
Weight adjusted by age0.70.81.11.1-1.1-0.7-0.8
Bone surface3.25.68.72.9-2.8-1.5-1.8
Bone volume3.45.79.03.0-2.9-1.6-1.7
Breakpoint value in progressive ratio session0.70.71.90.6-0.5-1.40.6
Number of licking bursts0.40.50.5-0.70.70.70.7
Context. condit. distance diff. score0.91.11.61.3-1.2-1.2-0.0
Locomotion velocity, session 12.32.54.81.6-1.6-2.20.1
Locomotion distance, session 10.70.91.41.2-1.2-0.5-0.9
Locomotion velocity, session 20.70.81.11.0-1.0-0.9-0.5
Locomotion distance, session 21.62.33.41.8-1.8-0.9-1.3
Locomotion velocity, session 33.94.57.3-2.62.71.61.1
Locomotion distance, session 30.30.41.20.2-0.10.4-1.1
Stereotopy head waving bouts, day 30.30.41.0-0.50.4-0.41.0
Stereotopy head waving duration, day 30.20.30.6-0.60.30.70.3
Locomotion velocity, session 71.31.52.11.3-1.3-0.5-1.4
Locomotion distance, session 71.72.23.21.8-1.7-0.8-1.5
Stereotopy head waving bouts, day 70.60.71.40.9-1.2-0.8-0.2
Stereotopy head waving duration, day 70.91.12.01.2-1.4-0.9-0.4
Locomotion velocity, session 80.60.71.00.9-1.0-0.4-0.9
Locomotion distance, session 81.72.53.41.8-1.8-1.8-0.4
Degree of sensitization distance0.90.91.61.0-1.0-1.30.3
Degree of sensitization stereotypy0.91.01.51.0-1.2-1.20.0
Conditioned locomotion0.30.40.9-0.60.51.00.1
Cocaine response after cond. corrected0.30.41.0-0.10.3-0.71.0
Cocaine response after cond. not corrected0.40.41.10.3-0.1-1.00.8
Cocaine response before conditioning1.01.21.61.3-1.3-1.0-0.9
Saline control response0.60.81.31.1-1.0-0.2-0.9
Bone: connectivity density4.97.712.03.5-3.3-2.2-1.8
Bone: cortical apparent density0.20.31.0-0.20.11.0-0.5
Bone: cortical area1.21.92.9-1.71.71.30.1
Bone: cortical porosity0.10.10.20.3-0.3-0.5-0.0
Bone: cortical porosity0.00.00.1-0.10.0-0.20.0
Bone: cortical thickness4.37.111.3-3.43.41.81.5
Bone: cortical thickness1.21.42.1-1.51.40.11.2
Bone: cortical tissue density0.20.20.7-0.00.00.9-0.4
Condit. Reinf. active minus inactive responses0.20.30.5-0.70.5-0.10.6
Condit. Reinf. active-inactive response ratio2.72.94.4-2.11.90.01.8
Condit. Reinf. active responses0.20.30.50.5-0.7-0.3-0.4
Condit. Reinf. inactive responses3.84.56.52.6-2.5-0.1-2.2
Incentive salience index mean0.20.20.4-0.60.4-0.40.5
Condit. Reinf. lever presses0.40.62.00.1-0.3-1.40.4
Condit. Reinf. active minus inactive responses0.30.40.70.7-0.9-0.4-0.4
Condit. Reinf. active-inactive response ratio0.20.20.4-0.50.3-0.20.7
Condit. Reinf. active responses1.21.62.71.3-1.6-0.2-1.4
Condit. Reinf. inactive responses3.64.57.42.2-2.30.3-2.7
Condit. Reinf. lever presses0.60.81.50.0-0.11.2-1.2
Condit. Reinf. lever reinforcers received1.21.62.41.3-1.60.0-1.6
Conditioned reinforcement - actives2.42.43.61.9-1.8-0.6-1.5
Conditioned reinforcement - inactives0.70.81.30.9-1.0-0.1-1.1
Conditioned locomotion0.20.20.6-0.10.10.5-0.8
Patch foraging indifference point 0 sec0.30.40.90.6-0.5-0.3-0.9
Patch foraging indifference point AUC0.40.41.3-0.1-0.11.2-0.6
Delay disc. indifference point, 0s delay0.00.00.1-0.2-0.3-0.10.1
Delay disc. indifference point, 16s delay0.70.80.9-1.00.90.90.6
Delay disc. indifference point, 2s delay1.11.21.7-1.21.31.00.7
Delay disc. indifference point, 24s delay0.20.20.3-0.50.60.40.1
Delay disc. indifference point, 4s delay1.11.22.0-1.41.20.41.1
Delay disc. indifference point, 8s delay0.80.81.3-1.11.10.60.7
Indifference point function ln k0.60.91.01.0-1.0-1.0-0.7
Indifference point function log k0.60.91.01.0-1.0-1.0-0.7
Patch foraging total patch changes 0 sec0.30.51.10.7-0.6-0.2-1.1
Patch foraging total patch changes 12 sec0.40.50.8-0.90.90.60.1
Patch foraging total patch changes 18 sec0.70.91.5-1.21.00.50.8
Patch foraging total patch changes 24 sec0.60.71.0-0.90.91.0-0.2
Patch foraging total patch changes 6 sec0.30.51.10.1-0.00.9-1.0
Patch foraging time to switch 0 sec1.62.54.3-1.71.7-0.32.1
Patch foraging water rate 0 sec0.81.32.61.1-1.10.5-1.6
Patch foraging water rate 12 sec0.00.00.00.2-0.2-0.2-0.0
Patch foraging water rate 18 sec2.43.25.52.3-2.2-1.2-1.1
Patch foraging water rate 24 sec0.40.61.00.8-0.90.1-1.0
Patch foraging water rate 6 sec0.20.30.6-0.10.10.8-0.7
Seeking ratio, delayed vs. immediate footshock1.11.22.9-0.90.91.7-0.6
Distance traveled before self-admin1.51.62.2-1.41.51.50.3
Distance traveled after self-admin0.10.10.2-0.50.3-0.20.3
Extensor digitorum longus weight5.120.130.65.5-5.5-2.2-3.8
Bone: elastic displacement0.30.30.9-0.40.41.0-0.3
Bone: elastic work3.24.16.8-2.62.61.60.7
Bone: endosteal estimation0.10.30.40.6-0.50.1-0.7
Bone: endosteal perimeter0.91.92.71.6-1.60.1-1.7
Epididymis fat weight2.45.68.02.7-2.6-2.8-0.1
Delta time in closed arm before/after self-admin0.20.20.6-0.40.10.7-0.2
Delta time in open arm before/after self-admin0.60.61.30.7-0.7-1.2-0.2
Diff in mean of infusions in LGA sessions0.50.61.80.0-0.1-1.30.8
Delay discount exponential model param1.51.62.51.6-1.5-0.9-0.8
Extinction: sum of active levers before priming1.81.72.61.4-1.6-1.4-0.8
Active lever presses in extinction session 61.21.11.51.2-1.2-1.0-0.8
Bone: final force0.61.01.9-1.31.4-0.20.5
Bone: final moment0.50.81.6-1.21.3-0.00.3
Food consumed during 24 hour testing period0.20.30.40.5-0.5-0.6-0.4
Glucose2.63.95.5-2.32.32.00.8
Heart weight0.10.10.30.1-0.2-0.60.1
Delay discount hyperbolic model param1.41.52.41.5-1.4-1.0-0.7
Intermittent access intake day 1-15 change1.31.32.80.7-0.51.3-1.7
Intermittent access intake escalation1.00.92.6-0.10.21.6-1.0
Intermittent access intake escalation 21.11.13.3-0.60.71.8-0.5
Intermitt. access day 1 inactive lever presses2.22.43.6-1.91.71.70.3
Intermitt. access day 15 inactive lever presses0.50.51.2-0.70.61.10.1
Intermitt. access escalation Index3.63.27.4-0.20.3-2.32.7
Intermittent access day 1 total infusions0.60.71.01.0-1.0-0.5-0.7
Intermittent access day 15 total infusions1.51.73.71.2-1.20.6-1.9
Intermittent access terminal intake (last 3 days)1.61.82.71.6-1.6-0.5-1.3
Intermittent access total infusions0.91.01.91.0-0.90.2-1.4
Intermittent access day 1 locomotion0.20.20.4-0.60.60.20.0
Intermittent access day 15 total locomotion0.30.40.8-0.20.10.9-0.7
Intermittent access total locomotion0.10.10.3-0.00.10.4-0.5
Intermittent access standard deviation2.32.45.00.5-0.42.1-2.2
Left kidney weight3.08.412.3-3.53.50.83.0
Right kidney weight2.57.110.2-3.13.20.42.9
Cocaine induced anxiety0.40.50.80.4-0.40.9-0.9
Post-drug Anxiety0.20.20.30.6-0.60.2-0.4
Baseline Anxiety0.10.10.3-0.20.2-0.40.6
Tail length1.95.813.2-1.11.1-2.83.6
Length with tail1.03.78.6-0.30.3-2.52.9
Length without tail0.71.63.21.2-1.2-1.80.6
Times rat made contact with spout1.31.52.5-1.61.50.11.1
Lifetime Intake0.91.02.21.0-0.90.3-1.5
Liver weight, left1.32.04.3-0.80.8-1.62.1
Liver weight, right0.61.12.3-0.20.2-1.51.4
Locomotor activity0.00.10.10.2-0.4-0.3-0.0
Locomotor testing distance0.00.00.10.1-0.3-0.20.0
Locomotor testing rearing0.40.61.00.9-1.0-0.0-0.7
Locomotion in novel chamber2.22.87.2-0.50.52.7-1.9
Locomotion in novel chamber post-restriction0.30.30.80.5-0.50.2-0.9
Fecal boli incidents, locomotor time 10.10.10.20.4-0.1-0.3-0.0
Change in fecal boli incidents, locomotor task0.70.71.1-1.10.9-0.00.9
Time >=10cm from walls, locomotor time 10.60.62.00.4-0.50.1-1.4
Bouts of movement, locomotor time 10.10.10.20.4-0.4-0.3-0.3
Total resting periods, locomotor time 10.10.20.20.4-0.5-0.2-0.4
Rest time, locomotor task time 10.10.20.20.3-0.30.5-0.5
Distance moved, locomotor task time 10.10.10.30.3-0.2-0.0-0.5
Vertical activity count, locomotor time 10.70.71.00.9-1.0-0.4-1.0
Time >=10cm from walls, locomotor time 20.80.81.3-1.21.00.8-0.5
Bouts of movement, locomotor time 20.20.30.4-0.60.50.20.6
Total resting periods, locomotor time 20.10.10.1-0.20.2-0.10.4
Rest time, locomotor task time 20.20.20.40.6-0.6-0.20.1
Distance moved, locomotor task time 20.30.40.8-0.3-0.10.9-0.8
Vertical activity count, locomotor time 20.30.30.5-0.70.60.50.2
Light reinforcement 10.00.00.10.1-0.3-0.0-0.1
Light reinforcement 22.12.84.4-2.12.00.91.4
Bone: marrow area0.10.20.40.5-0.50.1-0.6
Bone: maximum diameter0.50.82.60.4-0.40.7-1.6
Bone: maximum force0.61.12.1-1.41.50.20.5
Bone: maximum moment0.50.91.8-1.21.30.40.3
Mean time between licks in bursts0.40.61.8-0.30.2-0.71.3
Mean num. licks in bursts0.20.20.5-0.40.4-0.70.2
Cd content in liver0.80.81.51.2-1.2-0.60.2
Co content in liver0.10.20.2-0.50.40.50.1
Cu content in liver0.91.11.7-1.31.30.31.0
Fe content in liver0.60.71.9-0.40.3-0.81.4
K content in liver1.11.11.5-1.11.0-0.91.2
Mg content in liver0.10.10.4-0.00.00.2-0.6
Mn content in liver0.40.40.60.7-0.7-0.4-0.8
Na content in liver2.83.04.8-2.22.10.91.4
Rb content in liver1.51.92.61.6-1.6-0.4-1.6
Se content in liver1.01.21.8-1.31.30.61.0
Sr content in liver0.70.71.01.0-1.0-0.6-0.6
Zn content in liver0.70.81.31.0-0.90.0-1.2
Bone: minimum diameter0.91.62.3-1.41.50.41.4
Time in familiar zone, hab. session 12.12.03.71.5-1.40.2-1.9
Time in novel zone, hab. session 11.91.83.3-1.51.3-0.11.8
Total zone transitions, hab. session 12.33.34.62.1-2.10.0-2.0
Total locomotion distance, hab. session 10.50.81.51.2-1.2-0.2-0.5
Locomotion velocity, hab. session 10.71.01.81.4-1.2-0.1-0.8
Time in familiar zone, hab. session 21.92.03.41.8-1.8-0.5-1.0
Time in novel zone, hab. session 24.44.47.4-2.72.70.91.5
Total zone transitions, hab. session 20.91.21.91.4-1.4-0.7-0.8
Total locomotion distance, hab. session 20.10.10.10.4-0.3-0.40.1
Locomotion velocity, hab. session 20.00.10.10.3-0.3-0.30.1
Novel to familiar place preference ratio0.30.30.80.00.10.7-0.9
Novelty place preference0.10.10.3-0.00.10.3-0.5
Time in novel zone, NPP test0.10.10.20.2-0.10.0-0.5
Total zone transitions, NPP test1.21.82.71.7-1.6-0.1-1.3
Total locomotion distance, NPP test0.40.60.80.9-0.80.5-0.9
Locomotion velocity, NPP test0.40.61.00.5-0.41.0-1.0
Intraocular pressure0.91.21.80.8-0.81.3-1.4
Delta distance traveled before/after self-admin1.21.33.40.9-1.1-1.80.1
Delta ambulatory time before/after self-admin1.01.12.80.8-1.0-1.70.2
Parametrial fat weight5.310.320.33.1-3.3-4.50.4
Pavlov. Cond. lever latency0.40.40.60.8-0.70.4-0.7
Pavlov. Cond. magazine entry latency0.30.41.30.1-0.1-1.10.5
Pavlov. Cond. change in total contacts0.60.61.1-1.10.90.40.6
Pavlov. Cond. index score0.30.41.3-0.20.1-1.10.6
Pavlov. Cond. latency score0.50.71.5-0.40.3-1.21.0
Pavlov. Cond. lever contacts0.30.30.4-0.60.5-0.50.6
Pavlov. Cond. magazine entry number0.10.10.3-0.10.10.6-0.4
Pavlov. Cond. intertrial magazine entries0.81.01.40.9-1.00.7-1.2
Pavlov. Cond. lever-magazine prob. diff.0.20.31.0-0.0-0.0-1.00.4
Pavlov. Cond. response bias0.20.20.70.0-0.1-0.80.4
Pavlov. Cond. lever latency0.91.22.21.2-1.1-1.5-0.1
Pavlov. Cond. magazine entry latency1.11.32.2-1.31.50.51.0
Pavlov. Cond. change in total contacts0.60.91.4-1.21.10.90.2
Pavlov. Cond. index score1.21.62.4-1.41.41.60.3
Pavlov. Cond. latency score1.51.83.0-1.41.51.70.3
Pavlov. Cond. lever contacts0.60.81.1-1.11.10.90.4
Pavlov. Cond. magazine entry number1.21.52.51.4-1.6-0.8-0.8
Pavlov. Cond. intertrial magazine entries1.92.54.31.9-2.1-1.0-1.0
Pavlov. Cond. lever-magazine prob. diff.1.11.42.2-1.31.31.50.2
Pavlov. Cond. response bias1.01.32.0-1.41.41.00.7
Time in closed arm before self-admin1.31.53.01.3-1.1-1.70.4
Time in closed arm after self-admin0.10.10.3-0.30.30.20.5
Time in open arm before self-admin4.04.36.6-2.62.42.20.5
Time in open arm after self-admin0.70.81.3-1.11.00.8-0.4
Bone: periosteal estimation0.20.40.7-0.80.80.7-0.1
Bone: periosteal perimeter0.20.30.8-0.00.10.7-0.9
Bone: post-yield work0.20.20.60.3-0.4-0.80.2
Progressive ratio test 1 active lever presses0.40.40.60.8-0.6-0.4-0.6
Progressive ratio test 1 breakpoint0.70.81.31.1-1.0-0.7-0.7
Progressive ratio test 1 inactive lever presses0.50.61.0-0.60.61.0-0.7
Progressive ratio test 2 active lever presses0.70.71.40.9-0.80.2-1.2
Progressive ratio test 2 breakpoint0.70.81.60.9-0.70.3-1.3
Progressive ratio test 2 inactive lever presses0.70.82.20.3-0.30.8-1.5
Incentive Sensitization - Responses0.30.30.60.4-0.50.4-0.8
Incentive Sensitization - Breakpoint0.20.20.40.3-0.30.4-0.6
Sum of active levers in priming session hrs 5-61.21.23.00.8-1.0-1.7-0.0
Progressive ratio1.11.23.10.9-0.90.4-1.8
Food seeking constrained by brief footshock0.10.10.2-0.30.30.40.3
Seeking ratio, punishment vs. effort1.41.73.6-1.31.30.11.9
Retroperitoneal fat weight0.00.10.3-0.20.20.10.5
Reaction time number correct0.00.10.20.1-0.3-0.40.1
Reaction time mean minus median0.20.20.60.2-0.10.8-0.4
Reaction time mean minus median AUC1.01.31.91.4-1.40.3-1.2
Reaction time num false alarms1.11.52.91.0-0.91.1-1.7
Reaction time num false alarms AUC1.11.53.40.9-0.81.2-1.8
Reaction time trials correct on left0.00.10.20.1-0.3-0.40.1
Reaction time trials on left0.00.10.10.1-0.3-0.4-0.0
Reaction time mean0.10.20.2-0.20.40.40.4
Reaction time mean AUC0.20.30.7-0.30.50.90.2
Median of all reaction times0.30.40.6-0.50.70.40.8
Reaction time omissions0.00.00.0-0.20.20.0-0.0
Reaction time false alarm rate0.91.32.80.9-0.71.1-1.7
Reaction time premature initiation rate0.50.60.90.9-0.9-0.4-0.8
Reaction time premature initiations0.60.81.31.0-1.1-0.5-0.8
Std. dev. reaction times0.20.30.60.3-0.10.7-0.7
Reaction time trials completed0.00.10.10.1-0.3-0.4-0.0
Reaction time trials AUC0.00.10.10.1-0.3-0.3-0.1
Run reversals in cocaine runway, females0.40.41.10.1-0.11.1-0.6
Run reversals in cocaine runway, males0.50.40.50.7-0.70.5-0.6
Latency to leave start box in cocaine runway0.20.20.3-0.50.50.10.4
Latency to leave start box in cocaine runway, F0.20.20.4-0.50.5-0.20.7
Latency to leave start box in cocaine runway, M0.00.00.1-0.20.1-0.20.1
Std. dev. time between licks in bursts0.40.50.70.8-0.8-0.2-0.7
Total sessions with >9 infusions0.20.20.50.5-0.4-0.2-0.7
Short access day 1 total inactive lever presses0.20.20.30.4-0.4-0.5-0.4
Short access day 10 total inactive lever presses0.40.40.8-0.90.8-0.00.3
Short access day 1 total infusions0.91.02.60.3-0.31.1-1.6
Short access day 10 total infusions1.11.21.81.2-1.2-0.0-1.4
Short access total infusions0.91.02.30.9-0.80.6-1.5
Short access day 1 locomotion0.40.41.1-0.00.10.7-1.1
Short access day 10 total locomotion0.40.40.5-0.70.70.7-0.4
Short access total locomotion0.40.51.1-0.20.20.8-1.1
One hour access (0.3 mA shock)2.02.33.71.7-1.6-0.1-1.9
Compulsive drug intake0.40.40.7-0.30.3-0.80.9
One hour access (shock baseline)1.21.42.41.3-1.20.4-1.6
Social response proportion1.51.75.30.5-0.6-2.30.8
Social responses1.01.33.11.0-1.1-1.8-0.0
Social time2.02.64.31.8-1.8-2.1-0.0
Soleus weight2.36.912.52.7-2.8-3.50.4
Bone: stiffness0.50.82.40.7-0.6-1.50.1
Tibialis anterior weight7.927.139.96.3-6.3-3.6-4.0
Time to tail flick, vehicle, before self-admin4.64.76.72.4-2.6-2.4-0.8
Time to tail flick, vehicle, after self-admin1.11.21.91.2-1.4-0.2-1.2
Time to tail flick, test, before self-admin0.60.60.91.0-0.8-0.7-0.4
Time to tail flick, test, after self-admin0.20.30.70.1-0.1-0.80.6
Delta time to tail flick, vehicle, before/after SA0.70.71.9-0.40.41.4-0.7
Delta time to tail flick, test, before/after SA0.00.00.10.1-0.20.1-0.3
Tibia length1.02.85.0-1.61.6-1.12.2
Ambulatory time before self-admin2.22.33.5-1.71.91.30.9
Ambulatory time after self-admin0.91.01.9-0.60.5-1.11.4
Bone: tissue strength1.91.83.1-1.71.70.90.7
Total heroin consumption2.73.16.11.8-1.8-2.5-0.3
Bone: trabecular number3.65.68.83.0-2.9-1.9-1.2
Bone: trabecular spacing0.50.71.2-1.11.00.8-0.1
Bone: trabecular thickness0.20.30.50.7-0.6-0.4-0.2
Bone: trabecular tissue density1.92.63.8-1.91.91.50.8
Water consumed over 24 hours0.70.81.4-0.80.9-0.71.2
Number of responses in last shaping day0.70.81.3-0.70.81.2-0.7