Myo1c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	intron excision ratio	chr10_60997757_61003351	0.08	0.05	1.1e-05	0.03	0.03	0.02	0.03	1.9e-04	5.2e-04	1.5e-03	4.9e-04
2	Brain	alternative TSS	XM_039086809.1	0.05	0.04	5.9e-03	0.01	0.02	0.03	0.01	2.6e-02	3.2e-03	2.0e-03	1.7e-02
3	Adipose	mRNA stability	Myo1c	0.06	0.06	9.8e-03	0	-0	0.01	-0	2.7e-01	4.0e-01	6.2e-02	4.6e-01
4	pVTA	gene expression	Myo1c	0.07	0.05	1.5e-03	0.04	0.03	0.03	0.05	4.5e-04	9.5e-04	1.6e-03	8.8e-05
5	Adipose	gene expression	Myo1c	0.19	0.12	9.9e-05	0.02	0.03	0.03	0.02	1.1e-03	9.9e-05	2.5e-04	3.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.1	3.6	8.2	2.9	2.1	-1.8	-1.5	-0.7
Area under the delay curve	1.1	1.3	2.0	-1.3	-1.2	1.1	1.4	0.6
BMI with tail	0.8	2.7	4.5	2.1	2.0	-1.6	-0.7	-1.4
BMI without tail	0.2	0.6	1.4	1.2	0.6	0.1	0.9	0.7
Body weight	0.6	2.6	5.3	1.0	-0.2	1.2	2.2	2.3
Weight adjusted by age	0.6	0.9	1.2	0.9	1.0	-1.1	-0.7	-1.0
Bone surface	2.4	4.4	8.8	3.0	2.2	-2.2	-1.3	-1.4
Bone volume	2.3	4.1	9.0	3.0	2.2	-2.1	-1.2	-1.2
Breakpoint value in progressive ratio session	0.2	0.2	0.5	0.7	0.1	0.1	0.3	0.5
Number of licking bursts	0.9	1.4	2.5	-0.7	-1.5	0.8	1.6	1.0
Context. condit. distance diff. score	0.7	0.8	1.4	1.2	1.1	-0.7	-1.0	-0.0
Locomotion velocity, session 1	0.9	1.0	2.6	1.6	1.2	-0.7	-0.7	0.1
Locomotion distance, session 1	0.5	0.6	1.3	1.1	0.6	-0.8	-0.4	-0.8
Locomotion velocity, session 2	0.5	0.5	1.1	1.1	0.6	-0.8	-0.6	-0.5
Locomotion distance, session 2	1.2	1.7	3.2	1.8	1.2	-1.3	-1.0	-1.1
Locomotion velocity, session 3	4.6	5.3	7.0	-2.7	-2.5	2.1	2.6	1.2
Locomotion distance, session 3	0.2	0.3	1.1	0.1	-0.0	-0.5	-0.0	-1.0
Stereotopy head waving bouts, day 3	0.4	0.5	1.1	-0.3	-0.4	0.7	0.8	1.0
Stereotopy head waving duration, day 3	0.2	0.2	0.8	-0.2	-0.4	0.3	0.9	0.4
Locomotion velocity, session 7	1.6	1.8	1.9	1.3	1.4	-1.3	-1.3	-1.4
Locomotion distance, session 7	2.0	2.5	2.8	1.6	1.6	-1.7	-1.6	-1.4
Stereotopy head waving bouts, day 7	0.3	0.4	1.1	1.0	0.5	-0.2	0.6	0.3
Stereotopy head waving duration, day 7	0.5	0.6	2.0	1.4	0.8	-0.6	0.4	-0.1
Locomotion velocity, session 8	0.7	0.8	1.0	0.9	0.7	-1.0	-0.9	-0.9
Locomotion distance, session 8	0.8	1.1	3.2	1.8	1.1	-0.9	-0.6	-0.2
Degree of sensitization distance	0.5	0.5	0.9	0.9	0.9	-0.4	-0.8	0.3
Degree of sensitization stereotypy	0.4	0.4	1.5	1.2	0.7	-0.3	0.3	0.2
Conditioned locomotion	0.1	0.1	0.2	-0.5	0.2	0.0	-0.2	-0.0
Cocaine response after cond. corrected	0.1	0.2	0.6	-0.2	0.0	0.3	-0.3	0.8
Cocaine response after cond. not corrected	0.1	0.1	0.4	0.2	0.2	0.1	-0.1	0.6
Cocaine response before conditioning	0.5	0.6	1.7	1.3	0.6	-0.8	0.1	-0.7
Saline control response	0.3	0.4	1.0	1.0	0.3	-0.8	0.2	-0.7
Bone: connectivity density	3.8	6.0	11.5	3.4	2.7	-2.3	-2.0	-1.4
Bone: cortical apparent density	0.2	0.3	0.6	-0.3	0.1	-0.4	-0.8	-0.7
Bone: cortical area	1.3	1.9	3.8	-2.0	-1.7	1.3	1.2	0.3
Bone: cortical porosity	0.0	0.0	0.1	0.3	0.2	-0.1	-0.0	0.1
Bone: cortical porosity	0.1	0.1	0.2	-0.2	-0.1	0.3	0.4	0.2
Bone: cortical thickness	5.0	8.3	13.6	-3.7	-3.2	2.9	2.5	1.6
Bone: cortical thickness	1.9	2.3	2.9	-1.7	-1.6	1.7	1.3	1.2
Bone: cortical tissue density	0.2	0.3	0.7	-0.1	0.2	-0.5	-0.8	-0.7
Condit. Reinf. active minus inactive responses	0.6	0.6	1.1	-0.6	-0.7	0.9	1.1	0.7
Condit. Reinf. active-inactive response ratio	4.2	4.5	5.4	-2.0	-2.0	2.3	2.3	1.9
Condit. Reinf. active responses	0.2	0.3	0.5	0.6	0.7	-0.4	-0.3	-0.2
Condit. Reinf. inactive responses	5.2	6.4	7.3	2.5	2.7	-2.7	-2.6	-2.2
Incentive salience index mean	0.3	0.4	0.7	-0.4	-0.5	0.8	0.7	0.6
Condit. Reinf. lever presses	0.1	0.1	0.2	0.3	0.2	0.4	-0.1	0.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	0.9	0.6	-0.6	-0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.4	-0.4	0.5	0.3	0.6
Condit. Reinf. active responses	1.1	1.6	2.6	1.6	1.1	-1.4	-0.6	-1.3
Condit. Reinf. inactive responses	3.6	4.6	6.2	2.5	1.9	-2.5	-1.0	-2.5
Condit. Reinf. lever presses	0.4	0.6	1.8	0.3	0.2	-0.9	0.2	-1.3
Condit. Reinf. lever reinforcers received	1.2	1.6	2.6	1.6	1.1	-1.5	-0.4	-1.4
Conditioned reinforcement - actives	1.7	2.9	3.5	1.7	1.9	-1.7	-1.8	-1.4
Conditioned reinforcement - inactives	0.3	0.4	0.5	0.7	0.5	-0.7	-0.7	-0.5
Conditioned locomotion	0.2	0.2	0.8	-0.1	-0.1	-0.4	0.2	-0.9
Patch foraging indifference point 0 sec	0.3	0.5	0.9	0.6	0.7	-0.8	-0.6	-0.9
Patch foraging indifference point AUC	0.2	0.2	0.6	0.0	0.1	-0.5	-0.8	-0.6
Delay disc. indifference point, 0s delay	0.1	0.1	0.5	0.5	0.1	-0.0	0.7	0.2
Delay disc. indifference point, 16s delay	1.1	1.2	1.8	-1.2	-1.1	1.0	1.4	0.7
Delay disc. indifference point, 2s delay	0.9	1.0	1.6	-1.0	-0.8	1.1	1.3	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.5	-0.5	0.3	0.3	-0.0
Delay disc. indifference point, 4s delay	1.4	1.4	2.1	-1.1	-1.4	1.1	1.3	1.0
Delay disc. indifference point, 8s delay	0.7	0.8	1.1	-1.0	-0.8	0.9	1.1	0.6
Indifference point function ln k	0.4	0.7	1.0	1.0	1.0	-0.7	-0.7	-0.6
Indifference point function log k	0.4	0.7	1.0	1.0	1.0	-0.7	-0.7	-0.6
Patch foraging total patch changes 0 sec	0.4	0.7	1.1	0.8	0.8	-0.9	-0.7	-1.1
Patch foraging total patch changes 12 sec	0.3	0.4	0.8	-0.8	-0.9	0.5	0.6	0.3
Patch foraging total patch changes 18 sec	0.9	1.4	2.1	-0.9	-1.4	1.1	1.5	1.0
Patch foraging total patch changes 24 sec	0.2	0.4	0.6	-0.8	-0.8	0.5	0.6	0.1
Patch foraging total patch changes 6 sec	0.2	0.3	1.0	0.2	0.2	-0.7	-0.2	-1.0
Patch foraging time to switch 0 sec	1.9	3.9	5.3	-1.5	-1.8	2.0	2.3	2.1
Patch foraging water rate 0 sec	0.8	1.6	2.6	0.9	1.0	-1.4	-1.3	-1.6
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.1	-0.2	0.1	0.2	0.1
Patch foraging water rate 18 sec	1.6	2.5	4.6	2.1	1.8	-1.6	-1.2	-0.9
Patch foraging water rate 24 sec	0.4	0.6	0.8	0.7	0.7	-0.9	-0.6	-0.9
Patch foraging water rate 6 sec	0.1	0.2	0.5	-0.3	-0.1	-0.3	-0.5	-0.7
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.8	-0.7	-0.6	0.1	0.9	-0.4
Distance traveled before self-admin	1.8	2.4	4.3	-2.1	-1.4	1.6	1.7	0.7
Distance traveled after self-admin	0.3	0.3	0.5	-0.7	-0.6	0.5	0.6	0.3
Extensor digitorum longus weight	4.9	19.2	29.0	5.4	4.8	-4.3	-3.8	-3.2
Bone: elastic displacement	0.1	0.1	0.2	-0.5	-0.2	-0.0	-0.2	-0.4
Bone: elastic work	3.3	4.3	7.9	-2.8	-2.4	2.0	1.8	0.7
Bone: endosteal estimation	0.2	0.4	0.9	0.8	0.5	-0.9	-0.3	-0.6
Bone: endosteal perimeter	1.4	2.9	3.9	1.8	1.6	-2.0	-1.5	-1.6
Epididymis fat weight	2.4	8.1	23.1	4.8	3.3	-2.2	-1.1	0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.3	-0.6	-0.1	0.0	-0.1
Delta time in open arm before/after self-admin	0.4	0.4	1.1	0.8	1.0	-0.2	-0.0	-0.3
Diff in mean of infusions in LGA sessions	0.4	0.4	0.8	0.9	0.8	-0.4	-0.7	0.1
Delay discount exponential model param	1.0	1.1	1.6	1.2	1.2	-1.0	-1.3	-0.6
Extinction: sum of active levers before priming	2.9	3.1	3.9	2.0	1.8	-1.8	-1.8	-1.5
Active lever presses in extinction session 6	2.0	2.0	2.9	1.7	1.6	-1.3	-1.3	-0.9
Bone: final force	1.7	2.7	4.5	-1.6	-1.8	1.6	2.1	0.8
Bone: final moment	1.2	1.9	3.2	-1.4	-1.5	1.3	1.8	0.5
Food consumed during 24 hour testing period	0.3	0.4	0.6	0.6	0.7	-0.6	-0.8	-0.4
Glucose	2.2	3.5	6.6	-2.6	-2.3	1.6	1.5	0.6
Heart weight	0.2	0.3	1.0	1.0	0.5	0.1	0.2	0.5
Delay discount hyperbolic model param	1.4	1.5	2.1	1.4	1.4	-1.2	-1.4	-0.7
Intermittent access intake day 1-15 change	0.3	0.6	1.3	0.0	0.2	-0.9	-0.9	-1.1
Intermittent access intake escalation	0.4	0.8	2.0	0.1	0.3	-1.0	-1.0	-1.4
Intermittent access intake escalation 2	0.4	0.5	1.0	-0.2	0.1	-0.8	-0.9	-1.0
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.2	-1.1	-0.6	-0.3	-0.5	-1.1
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.6	-0.8	-0.2	-0.3	-0.7	-0.8
Intermitt. access escalation Index	0.9	1.3	4.0	-0.3	-0.4	1.3	0.8	2.0
Intermittent access day 1 total infusions	0.0	0.1	0.3	-0.1	-0.1	0.2	0.6	0.1
Intermittent access day 15 total infusions	0.6	0.9	1.7	0.6	0.8	-1.1	-0.7	-1.3
Intermittent access terminal intake (last 3 days)	0.8	1.1	1.3	1.0	1.1	-1.2	-0.9	-1.0
Intermittent access total infusions	0.3	0.4	0.7	0.4	0.5	-0.7	-0.4	-0.9
Intermittent access day 1 locomotion	0.4	0.5	1.1	-0.6	-0.8	0.5	1.1	0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.3	-0.3	-0.1	0.3	-0.5
Intermittent access total locomotion	0.1	0.1	0.5	-0.0	-0.0	-0.3	0.0	-0.7
Intermittent access standard deviation	1.4	2.8	4.8	0.8	1.2	-1.9	-1.9	-2.2
Left kidney weight	2.9	13.7	18.1	-3.4	-3.8	3.8	4.3	3.2
Right kidney weight	2.9	13.3	17.1	-3.1	-3.7	3.8	4.1	3.4
Cocaine induced anxiety	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.4	-0.2
Post-drug Anxiety	0.2	0.2	0.7	0.2	0.1	0.4	-0.2	0.9
Baseline Anxiety	0.2	0.2	0.5	0.6	0.4	0.1	-0.2	0.7
Tail length	1.5	6.0	12.3	-0.5	-1.7	2.5	2.9	3.5
Length with tail	2.2	9.5	18.9	-1.1	-2.3	3.2	3.4	4.3
Length without tail	0.6	2.0	4.3	0.1	-0.9	1.3	1.7	2.1
Times rat made contact with spout	1.9	2.1	2.7	-1.5	-1.6	1.5	1.6	1.0
Lifetime Intake	0.3	0.4	0.8	0.3	0.6	-0.7	-0.5	-0.9
Liver weight, left	1.7	2.9	9.4	0.5	-0.4	1.6	1.4	3.1
Liver weight, right	1.1	1.9	6.0	0.7	-0.1	1.1	1.2	2.5
Locomotor activity	0.0	0.0	0.1	0.3	0.1	-0.0	0.2	0.1
Locomotor testing distance	0.0	0.1	0.2	0.3	0.0	0.0	0.4	0.2
Locomotor testing rearing	0.3	0.6	1.0	1.0	0.7	-1.0	-0.4	-0.7
Locomotion in novel chamber	1.2	1.6	4.6	-0.2	1.0	-1.1	-1.1	-2.2
Locomotion in novel chamber post-restriction	0.7	1.2	1.7	0.8	1.3	-1.1	-1.0	-1.2
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.1	0.1	0.4	0.2	0.2
Change in fecal boli incidents, locomotor task	0.5	0.5	0.8	-0.9	-0.7	0.7	0.2	0.7
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.8	0.5	0.9	-0.8	-1.1	-1.3
Bouts of movement, locomotor time 1	0.3	0.3	0.7	0.2	0.8	-0.3	-0.7	-0.3
Total resting periods, locomotor time 1	0.5	0.6	1.4	0.3	1.0	-0.5	-1.2	-0.5
Rest time, locomotor task time 1	0.2	0.2	0.8	-0.2	0.1	-0.4	-0.9	-0.4
Distance moved, locomotor task time 1	0.0	0.1	0.1	0.2	0.3	-0.2	-0.0	-0.3
Vertical activity count, locomotor time 1	0.3	0.6	1.3	1.0	1.1	-0.7	-0.2	-0.6
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.8	-0.9	-0.7	0.3	0.3	-0.6
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.4	-0.4	0.3	0.2	0.4
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.0	0.2
Rest time, locomotor task time 2	0.3	0.4	1.1	0.5	0.6	-0.5	-1.1	-0.0
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.1	-0.0	-0.2	0.3	-0.5
Vertical activity count, locomotor time 2	0.3	0.4	1.0	-0.5	-0.6	0.6	1.0	0.4
Light reinforcement 1	0.1	0.3	1.0	0.3	-0.3	0.0	1.0	0.3
Light reinforcement 2	2.8	4.2	6.0	-2.0	-2.3	2.0	2.5	1.5
Bone: marrow area	0.2	0.4	0.8	0.7	0.4	-0.9	-0.3	-0.6
Bone: maximum diameter	0.5	0.8	2.0	0.3	0.5	-1.1	-0.8	-1.4
Bone: maximum force	1.6	2.8	4.1	-1.7	-1.9	1.6	2.0	0.8
Bone: maximum moment	1.1	2.0	2.7	-1.5	-1.6	1.3	1.7	0.5
Mean time between licks in bursts	0.3	0.8	1.7	-0.2	-0.6	1.0	1.0	1.3
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	0.3	0.3	-0.5	-0.3
Cd content in liver	1.3	1.4	2.9	1.2	0.9	-1.3	-1.7	-0.6
Co content in liver	0.0	0.0	0.1	-0.3	-0.3	0.2	-0.1	-0.2
Cu content in liver	0.5	0.5	1.1	-1.1	-0.9	0.6	0.6	0.2
Fe content in liver	0.5	0.6	1.2	-0.1	-0.6	0.7	0.9	1.1
K content in liver	1.6	1.5	3.2	-0.7	-1.1	1.2	1.8	1.0
Mg content in liver	0.2	0.2	0.5	0.5	0.3	-0.5	-0.0	-0.7
Mn content in liver	1.2	1.3	1.6	1.0	1.0	-1.2	-1.2	-1.2
Na content in liver	2.8	3.0	3.9	-2.0	-1.4	1.9	2.0	1.3
Rb content in liver	3.8	4.4	5.9	2.4	2.1	-2.2	-1.9	-1.8
Se content in liver	0.5	0.6	1.7	-0.9	-1.3	0.5	0.6	0.3
Sr content in liver	2.6	2.3	2.9	1.3	1.7	-1.5	-1.7	-1.2
Zn content in liver	0.1	0.1	0.2	0.1	-0.0	0.1	-0.5	0.4
Bone: minimum diameter	1.2	2.2	2.5	-1.5	-1.6	1.5	1.5	1.3
Time in familiar zone, hab. session 1	3.4	3.3	4.5	1.4	1.7	-1.8	-2.1	-2.0
Time in novel zone, hab. session 1	2.8	2.8	3.4	-1.3	-1.7	1.7	1.9	1.8
Total zone transitions, hab. session 1	1.6	2.2	4.2	2.0	1.0	-1.8	-0.5	-1.5
Total locomotion distance, hab. session 1	0.3	0.4	1.4	1.2	0.3	-0.6	-0.0	-0.2
Locomotion velocity, hab. session 1	0.4	0.6	1.6	1.2	0.6	-0.8	-0.3	-0.6
Time in familiar zone, hab. session 2	1.4	1.5	3.0	1.7	1.2	-1.3	-0.9	-0.8
Time in novel zone, hab. session 2	3.9	3.9	6.8	-2.6	-2.0	2.0	1.7	1.3
Total zone transitions, hab. session 2	0.4	0.6	1.8	1.4	0.5	-0.6	0.4	-0.3
Total locomotion distance, hab. session 2	0.1	0.2	0.4	0.3	-0.4	0.2	0.7	0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.2	-0.4	0.2	0.5	0.3
Novel to familiar place preference ratio	0.5	0.5	1.2	-0.1	0.6	-0.6	-0.8	-1.1
Novelty place preference	0.2	0.3	0.5	-0.1	0.5	-0.3	-0.6	-0.7
Time in novel zone, NPP test	0.2	0.2	0.4	0.1	0.6	-0.4	-0.5	-0.6
Total zone transitions, NPP test	0.7	1.0	2.5	1.6	0.7	-1.1	0.0	-0.9
Total locomotion distance, NPP test	0.2	0.3	0.6	0.8	-0.0	-0.6	0.2	-0.5
Locomotion velocity, NPP test	0.2	0.2	0.6	0.4	-0.0	-0.6	-0.0	-0.8
Intraocular pressure	0.9	1.2	1.8	0.7	0.9	-1.3	-1.1	-1.4
Delta distance traveled before/after self-admin	1.0	1.1	2.1	1.4	1.0	-1.0	-1.1	-0.4
Delta ambulatory time before/after self-admin	1.1	1.4	2.0	1.4	1.2	-1.1	-1.4	-0.5
Parametrial fat weight	2.3	5.3	15.6	4.0	2.8	-1.6	-0.9	0.3
Pavlov. Cond. lever latency	0.5	0.6	0.9	0.6	0.7	-0.9	-0.9	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.0	0.1	0.4	-0.0	0.6
Pavlov. Cond. change in total contacts	0.6	0.6	1.0	-1.0	-0.8	0.8	0.7	0.7
Pavlov. Cond. index score	0.2	0.2	0.5	-0.1	-0.2	0.6	0.4	0.7
Pavlov. Cond. latency score	0.4	0.6	1.0	-0.4	-0.5	0.9	0.8	1.0
Pavlov. Cond. lever contacts	0.4	0.5	0.7	-0.6	-0.6	0.8	0.7	0.7
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.1	-0.3	0.0	0.3	-0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.9	0.9	0.5	-1.0	0.2	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.1	-0.0	0.4	0.2	0.5
Pavlov. Cond. response bias	0.0	0.1	0.2	0.1	0.2	0.2	0.0	0.5
Pavlov. Cond. lever latency	0.8	1.1	1.8	1.2	1.3	-0.7	-1.4	-0.1
Pavlov. Cond. magazine entry latency	2.8	3.4	5.8	-1.6	-2.1	1.6	2.4	1.3
Pavlov. Cond. change in total contacts	0.9	1.5	2.6	-1.3	-1.5	0.9	1.6	0.3
Pavlov. Cond. index score	1.5	2.0	3.5	-1.5	-1.8	1.0	1.9	0.4
Pavlov. Cond. latency score	1.6	2.1	3.6	-1.6	-1.8	1.0	1.9	0.3
Pavlov. Cond. lever contacts	0.9	1.2	2.5	-1.0	-1.3	0.8	1.6	0.5
Pavlov. Cond. magazine entry number	2.5	3.1	4.9	1.7	2.0	-1.6	-2.2	-1.1
Pavlov. Cond. intertrial magazine entries	2.1	3.2	4.6	2.2	2.1	-1.7	-1.7	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	2.9	-1.5	-1.7	0.9	1.7	0.3
Pavlov. Cond. response bias	1.6	2.2	3.6	-1.5	-1.7	1.2	1.9	0.8
Time in closed arm before self-admin	0.3	0.4	0.9	0.9	0.8	-0.0	-0.1	0.5
Time in closed arm after self-admin	0.4	0.5	0.7	-0.8	-0.4	0.8	0.5	0.8
Time in open arm before self-admin	1.7	1.8	4.0	-1.9	-2.0	1.0	0.6	0.3
Time in open arm after self-admin	0.2	0.2	0.7	-0.6	-0.1	-0.0	-0.2	-0.8
Bone: periosteal estimation	0.2	0.5	0.9	-0.8	-1.0	0.4	0.8	0.2
Bone: periosteal perimeter	0.1	0.1	0.4	-0.1	-0.1	-0.3	-0.2	-0.6
Bone: post-yield work	0.1	0.1	0.2	0.5	0.1	0.1	0.2	0.4
Progressive ratio test 1 active lever presses	0.0	0.0	0.2	-0.1	0.1	-0.1	0.2	-0.4
Progressive ratio test 1 breakpoint	0.0	0.1	0.2	0.0	0.2	-0.2	0.1	-0.5
Progressive ratio test 1 inactive lever presses	0.3	0.4	1.2	-1.1	-0.8	0.1	-0.1	-0.6
Progressive ratio test 2 active lever presses	1.5	1.8	2.5	1.0	1.3	-1.5	-1.3	-1.6
Progressive ratio test 2 breakpoint	1.6	1.8	2.4	1.0	1.4	-1.5	-1.3	-1.6
Progressive ratio test 2 inactive lever presses	0.5	0.8	2.1	0.1	0.5	-0.9	-1.0	-1.4
Incentive Sensitization - Responses	1.6	2.3	2.7	1.3	1.6	-1.6	-1.7	-1.4
Incentive Sensitization - Breakpoint	1.5	2.0	2.5	1.2	1.5	-1.5	-1.6	-1.3
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.7	1.2	1.3	-0.4	-0.6	-0.0
Progressive ratio	0.4	0.6	1.7	0.3	0.8	-0.7	-0.2	-1.3
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.1	-0.3	0.0	0.0	0.1
Seeking ratio, punishment vs. effort	1.3	1.9	2.9	-1.1	-1.6	1.4	1.0	1.7
Retroperitoneal fat weight	0.1	0.5	1.1	0.7	-0.1	0.1	1.0	1.0
Reaction time number correct	0.0	0.0	0.1	0.4	0.2	-0.0	0.3	0.1
Reaction time mean minus median	0.1	0.4	0.7	0.3	0.4	-0.7	-0.9	-0.6
Reaction time mean minus median AUC	0.8	2.1	2.7	1.5	1.4	-1.6	-1.6	-1.2
Reaction time num false alarms	0.8	1.2	2.2	0.9	0.8	-1.4	-0.6	-1.5
Reaction time num false alarms AUC	0.8	1.2	2.7	0.9	0.7	-1.4	-0.6	-1.6
Reaction time trials correct on left	0.0	0.0	0.1	0.4	0.2	-0.0	0.3	0.1
Reaction time trials on left	0.0	0.1	0.2	0.4	0.2	-0.1	0.2	-0.0
Reaction time mean	0.0	0.1	0.2	-0.1	-0.1	-0.1	-0.5	0.2
Reaction time mean AUC	0.1	0.1	0.4	-0.2	-0.1	-0.2	-0.6	-0.0
Median of all reaction times	0.1	0.1	0.3	-0.4	-0.4	0.3	-0.1	0.5
Reaction time omissions	0.1	0.1	0.3	0.3	0.3	-0.4	-0.5	-0.3
Reaction time false alarm rate	0.8	1.1	2.2	0.7	0.7	-1.2	-0.8	-1.5
Reaction time premature initiation rate	0.7	1.0	1.5	1.1	1.0	-0.9	-1.2	-0.8
Reaction time premature initiations	0.7	1.2	1.6	1.3	1.1	-1.1	-1.1	-0.9
Std. dev. reaction times	0.3	0.6	1.1	0.4	0.5	-0.9	-1.0	-0.8
Reaction time trials completed	0.0	0.1	0.2	0.4	0.2	-0.1	0.2	-0.0
Reaction time trials AUC	0.0	0.1	0.1	0.4	0.2	-0.1	0.2	-0.1
Run reversals in cocaine runway, females	0.5	0.5	0.9	0.3	-0.2	-1.0	-0.7	-0.9
Run reversals in cocaine runway, males	1.1	1.1	1.5	1.0	1.0	-1.2	-1.1	-0.9
Latency to leave start box in cocaine runway	0.2	0.3	0.6	-0.5	-0.8	0.3	0.6	0.3
Latency to leave start box in cocaine runway, F	0.4	0.5	0.9	-0.4	-1.0	0.5	0.7	0.6
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.1	0.0	-0.2	-0.0	-0.1
Std. dev. time between licks in bursts	0.2	0.3	0.7	0.5	0.8	-0.4	-0.1	-0.5
Total sessions with >9 infusions	0.5	0.6	1.2	0.4	0.6	-0.8	-0.7	-1.1
Short access day 1 total inactive lever presses	0.1	0.2	0.3	0.2	0.3	-0.4	-0.5	-0.6
Short access day 10 total inactive lever presses	0.2	0.4	0.8	-0.9	-0.8	0.0	-0.2	-0.7
Short access day 1 total infusions	0.5	0.6	1.8	-0.2	0.4	-0.7	-0.8	-1.3
Short access day 10 total infusions	0.2	0.3	0.6	0.2	0.5	-0.6	-0.3	-0.8
Short access total infusions	0.2	0.2	0.7	-0.2	0.2	-0.4	-0.4	-0.9
Short access day 1 locomotion	0.4	0.4	1.0	-1.0	-0.7	0.1	0.4	-0.8
Short access day 10 total locomotion	0.2	0.3	0.8	-0.6	-0.5	-0.2	-0.0	-0.9
Short access total locomotion	0.4	0.5	1.1	-1.0	-0.7	-0.2	0.1	-1.1
One hour access (0.3 mA shock)	1.4	1.6	1.9	1.3	1.4	-1.4	-1.1	-1.2
Compulsive drug intake	0.1	0.1	0.4	0.3	0.2	0.3	0.2	0.6
One hour access (shock baseline)	0.1	0.2	0.4	0.3	0.4	-0.6	-0.2	-0.6
Social response proportion	0.3	0.3	0.7	0.6	0.5	0.4	0.3	0.9
Social responses	0.4	0.5	1.5	1.2	0.9	-0.3	-0.0	0.1
Social time	0.8	1.1	2.8	1.7	1.3	-0.7	-0.5	0.1
Soleus weight	0.6	1.9	6.2	2.5	1.4	-0.5	-0.2	0.9
Bone: stiffness	0.1	0.2	0.7	0.4	-0.2	0.3	0.8	0.5
Tibialis anterior weight	6.9	23.5	38.7	6.2	5.3	-4.8	-3.9	-3.5
Time to tail flick, vehicle, before self-admin	4.2	4.3	7.9	2.8	2.3	-2.0	-1.8	-1.0
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.6	0.7	0.8	-0.4	-0.3	-0.1
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.7	0.5	-0.2	-0.2	0.1
Time to tail flick, test, after self-admin	0.3	0.3	0.5	-0.5	-0.4	0.6	0.2	0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.8	-0.9	-0.6	0.3	0.2	-0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.3	0.0	-0.2	-0.5	-0.4
Tibia length	1.3	3.5	4.3	-1.4	-1.7	2.1	2.0	2.0
Ambulatory time before self-admin	3.2	4.8	6.8	-2.6	-2.0	2.3	2.4	1.4
Ambulatory time after self-admin	1.0	1.2	1.6	-0.9	-0.9	1.2	1.1	1.2
Bone: tissue strength	1.9	1.9	2.9	-1.7	-1.4	1.4	1.6	0.6
Total heroin consumption	1.4	1.7	4.4	2.1	1.4	-1.1	-0.8	-0.3
Bone: trabecular number	2.4	4.0	8.9	3.0	2.1	-1.9	-1.5	-0.7
Bone: trabecular spacing	0.2	0.2	0.7	-0.8	-0.4	0.3	0.4	-0.4
Bone: trabecular thickness	0.1	0.2	0.6	0.8	0.4	-0.4	-0.2	-0.0
Bone: trabecular tissue density	1.3	1.9	3.8	-1.9	-1.6	1.2	1.0	0.7
Water consumed over 24 hours	1.4	1.9	2.8	-1.1	-1.7	1.3	1.4	1.3
Number of responses in last shaping day	0.4	0.5	1.1	-0.8	-0.6	-0.2	0.0	-1.0